Flt3 (Fms related receptor tyrosine kinase 3) - Rat Genome Database

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Gene: Flt3 (Fms related receptor tyrosine kinase 3) Rattus norvegicus
Analyze
Symbol: Flt3
Name: Fms related receptor tyrosine kinase 3
RGD ID: 61308
Description: Enables nuclear glucocorticoid receptor binding activity. Involved in cellular response to glucocorticoid stimulus and liver regeneration. Part of protein-containing complex. Human ortholog(s) of this gene implicated in gastrointestinal system cancer (multiple); leukemia (multiple); and prostate cancer. Orthologous to human FLT3 (fms related receptor tyrosine kinase 3); PARTICIPATES IN acute myeloid leukemia pathway; cytokine mediated signaling pathway; INTERACTS WITH 17beta-estradiol; 17beta-estradiol 3-benzoate; 2-acetamidofluorene.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: FL cytokine receptor; FMS-like tyrosine kinase 3; fms-related tyrosine kinase 3; LOC304265; receptor-type tyrosine-protein kinase FLT3
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Candidate Gene For: Cia12
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81212,660,035 - 12,735,584 (+)NCBIGRCr8
GRCr8 Ensembl1212,659,946 - 12,735,581 (+)EnsemblGRCr8 Ensembl
mRatBN7.2127,623,930 - 7,699,474 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl127,623,930 - 7,699,474 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx128,309,422 - 8,384,638 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0128,932,574 - 9,007,795 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0127,960,581 - 8,035,804 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0129,360,439 - 9,437,004 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl129,360,672 - 9,436,570 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01211,478,443 - 11,552,730 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4128,193,629 - 8,268,682 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera129,364,576 - 9,437,757 (+)NCBICelera
RGSC_v3.1128,280,429 - 8,290,827 (+)NCBI
Cytogenetic Map12p11NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
animal organ development  (IEA)
antigen processing and presentation  (ISO)
B cell differentiation  (IBA,ISO)
cell migration  (IBA)
cell population proliferation  (ISO)
cell surface receptor protein tyrosine kinase signaling pathway  (IBA,IEA)
cell surface receptor signaling pathway  (IEA)
cellular response to cytokine stimulus  (ISO)
cellular response to glucocorticoid stimulus  (IEP)
cellular response to virus  (ISO)
common myeloid progenitor cell proliferation  (ISO)
cytokine-mediated signaling pathway  (IBA,ISO)
dendritic cell differentiation  (ISO)
dendritic cell homeostasis  (ISO)
hemopoiesis  (IEA,ISO)
homeostasis of number of cells within a tissue  (ISO)
leukocyte homeostasis  (ISO)
liver regeneration  (IEP)
lymph node development  (ISO)
lymphocyte differentiation  (ISO)
lymphocyte proliferation  (ISO)
lymphoid progenitor cell differentiation  (ISO)
myeloid progenitor cell differentiation  (ISO)
negative regulation of B cell differentiation  (ISO)
negative regulation of cell population proliferation  (ISO)
negative regulation of interleukin-6 production  (ISO)
negative regulation of tumor necrosis factor production  (ISO)
positive regulation of cell population proliferation  (IBA)
positive regulation of interferon-alpha production  (ISO)
positive regulation of interleukin-12 production  (ISO)
positive regulation of macromolecule metabolic process  (IEA)
positive regulation of multicellular organism growth  (ISO)
positive regulation of protein phosphorylation  (ISO)
positive regulation of type II interferon production  (ISO)
post-embryonic development  (ISO)
pro-B cell differentiation  (ISO)
pro-T cell differentiation  (ISO)
protein autophosphorylation  (ISO)
protein phosphorylation  (ISO)
spleen development  (ISO)
system development  (IEA)

Cellular Component

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Identification of novel FLT-3 Asp835 mutations in adult acute myeloid leukaemia. Abu-Duhier FM, etal., Br J Haematol. 2001 Jun;113(4):983-8.
2. FMS-like tyrosine kinase 3 interacts with the glucocorticoid receptor complex and affects glucocorticoid dependent signaling. Asadi A, etal., Biochem Biophys Res Commun. 2008 Apr 11;368(3):569-74. Epub 2008 Feb 7.
3. Cloning and expression profile of FLT3 gene during progenitor cell-dependent liver regeneration. Aydin IT, etal., J Gastroenterol Hepatol. 2007 Dec;22(12):2181-8.
4. Role of FLT3 in the proliferation and aggressiveness of hepatocellular carcinoma. Aydin MM, etal., Turk J Med Sci. 2016 Feb 17;46(2):572-81. doi: 10.3906/sag-1501-173.
5. Emergence of polyclonal FLT3 tyrosine kinase domain mutations during sequential therapy with sorafenib and sunitinib in FLT3-ITD-positive acute myeloid leukemia. Baker SD, etal., Clin Cancer Res. 2013 Oct 15;19(20):5758-68. doi: 10.1158/1078-0432.CCR-13-1323. Epub 2013 Aug 22.
6. Flt3 ligand antitumor activity in a murine breast cancer model: a comparison with granulocyte-macrophage colony-stimulating factor and a potential mechanism of action. Braun SE, etal., Hum Gene Ther. 1999 Sep 1;10(13):2141-51.
7. Expression of the hematopoietic growth factor receptor FLT3 (STK-1/Flk2) in human leukemias. Carow CE, etal., Blood. 1996 Feb 1;87(3):1089-96.
8. Flt3-ligand induces transient tumor regression in an ectopic treatment model of major histocompatibility complex-negative prostate cancer. Ciavarra RP, etal., Cancer Res. 2000 Apr 15;60(8):2081-4.
9. Stability and prognostic influence of FLT3 mutations in paired initial and relapsed AML samples. Cloos J, etal., Leukemia. 2006 Jul;20(7):1217-20. Epub 2006 Apr 27.
10. FLT3-mediated p38-MAPK activation participates in the control of megakaryopoiesis in primary myelofibrosis. Desterke C, etal., Cancer Res. 2011 Apr 15;71(8):2901-15. doi: 10.1158/0008-5472.CAN-10-1731. Epub 2011 Apr 12.
11. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
12. Identification of four new quantitative trait loci regulating arthritis severity and one new quantitative trait locus regulating autoantibody production in rats with collagen-induced arthritis. Griffiths MM, etal., Arthritis Rheum 2000 Jun;43(6):1278-89
13. FLT3-ITD and tyrosine kinase domain mutants induce 2 distinct phenotypes in a murine bone marrow transplantation model. Grundler R, etal., Blood. 2005 Jun 15;105(12):4792-9. Epub 2005 Feb 17.
14. FMS-like tyrosine kinase 3 (FLT3) amplification in patients with metastatic colorectal cancer. Hasegawa H, etal., Cancer Sci. 2021 Jan;112(1):314-322. doi: 10.1111/cas.14693. Epub 2020 Nov 20.
15. Safety and biological activity of repeated doses of recombinant human Flt3 ligand in patients with bone scan-negative hormone-refractory prostate cancer. Higano CS, etal., Clin Cancer Res. 2004 Feb 15;10(4):1219-25.
16. Promoter-associated DNA methylation & expression profiling of genes (FLT 3, EPB41L3 & SFN) in patients with oral squamous cell carcinoma in the Khasi & Jaintia population of Meghalaya, India. Khongsti S, etal., Indian J Med Res. 2019 Dec;150(6):584-591. doi: 10.4103/ijmr.IJMR_620_18.
17. FLT3 mutations confer enhanced proliferation and survival properties to multipotent progenitors in a murine model of chronic myelomonocytic leukemia. Lee BH, etal., Cancer Cell. 2007 Oct;12(4):367-80.
18. BPR1J-097, a novel FLT3 kinase inhibitor, exerts potent inhibitory activity against AML. Lin WH, etal., Br J Cancer. 2012 Jan 31;106(3):475-81. doi: 10.1038/bjc.2011.564. Epub 2011 Dec 20.
19. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
20. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
21. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
22. NPMc+ cooperates with Flt3/ITD mutations to cause acute leukemia recapitulating human disease. Rau R, etal., Exp Hematol. 2014 Feb;42(2):101-13.e5. doi: 10.1016/j.exphem.2013.10.005. Epub 2013 Oct 29.
23. GOA pipeline RGD automated data pipeline
24. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
25. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
26. Comprehensive gene review and curation RGD comprehensive gene curation
27. Effect of Flt3 ligand gene transfer in experimental pancreatic cancer. Ryschich E, etal., Int J Colorectal Dis. 2007 Feb;22(2):215-23. Epub 2006 Mar 10.
28. Orthotopic treatment model of prostate cancer and metastasis in the immunocompetent mouse: efficacy of flt3 ligand immunotherapy. Somers KD, etal., Int J Cancer. 2003 Dec 10;107(5):773-80.
29. Activating mutation of D835 within the activation loop of FLT3 in human hematologic malignancies. Yamamoto Y, etal., Blood. 2001 Apr 15;97(8):2434-9.
Additional References at PubMed
PMID:7507245   PMID:7621074   PMID:7630197   PMID:7919361   PMID:8183574   PMID:8384358   PMID:9620281   PMID:12387740   PMID:14759363   PMID:16618805   PMID:18245664   PMID:18469816  
PMID:20360400   PMID:20457904   PMID:21228325   PMID:21539498   PMID:21813452   PMID:22674806   PMID:23418353   PMID:23528453  


Genomics

Comparative Map Data
Flt3
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81212,660,035 - 12,735,584 (+)NCBIGRCr8
GRCr8 Ensembl1212,659,946 - 12,735,581 (+)EnsemblGRCr8 Ensembl
mRatBN7.2127,623,930 - 7,699,474 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl127,623,930 - 7,699,474 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx128,309,422 - 8,384,638 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0128,932,574 - 9,007,795 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0127,960,581 - 8,035,804 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0129,360,439 - 9,437,004 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl129,360,672 - 9,436,570 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01211,478,443 - 11,552,730 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4128,193,629 - 8,268,682 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera129,364,576 - 9,437,757 (+)NCBICelera
RGSC_v3.1128,280,429 - 8,290,827 (+)NCBI
Cytogenetic Map12p11NCBI
FLT3
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381328,003,274 - 28,100,576 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1328,003,274 - 28,100,592 (-)EnsemblGRCh38hg38GRCh38
GRCh371328,577,411 - 28,674,713 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361327,475,411 - 27,572,729 (-)NCBINCBI36Build 36hg18NCBI36
Build 341327,475,752 - 27,572,703NCBI
Celera139,652,471 - 9,749,817 (-)NCBICelera
Cytogenetic Map13q12.2NCBI
HuRef139,398,611 - 9,496,033 (-)NCBIHuRef
CHM1_11328,546,018 - 28,643,312 (-)NCBICHM1_1
T2T-CHM13v2.01327,225,623 - 27,323,127 (-)NCBIT2T-CHM13v2.0
Flt3
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm395147,267,551 - 147,337,299 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl5147,267,551 - 147,337,299 (-)EnsemblGRCm39 Ensembl
GRCm385147,330,741 - 147,400,489 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl5147,330,741 - 147,400,489 (-)EnsemblGRCm38mm10GRCm38
MGSCv375148,142,317 - 148,212,065 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv365147,641,095 - 147,710,644 (-)NCBIMGSCv36mm8
Celera5145,322,183 - 145,394,029 (-)NCBICelera
Cytogenetic Map5G3NCBI
cM Map586.88NCBI
Flt3
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554977,357,212 - 7,461,439 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049554977,357,533 - 7,441,215 (-)NCBIChiLan1.0ChiLan1.0
FLT3
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21427,590,058 - 27,688,013 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11318,694,458 - 18,792,575 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0139,283,747 - 9,381,553 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11327,627,178 - 27,694,863 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1327,627,178 - 27,723,940 (-)Ensemblpanpan1.1panPan2
FLT3
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12511,551,372 - 11,670,891 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2511,581,206 - 11,692,284 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha2511,657,250 - 11,733,707 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.02511,678,532 - 11,799,840 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl2511,678,653 - 11,799,832 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.12511,617,543 - 11,693,992 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02511,610,080 - 11,686,320 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02511,653,606 - 11,730,223 (+)NCBIUU_Cfam_GSD_1.0
Flt3
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024404945172,712,952 - 172,782,113 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493647223,170,470 - 23,256,904 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_00493647223,169,967 - 23,239,178 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
FLT3
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl115,370,496 - 5,455,358 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1115,370,475 - 5,455,439 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2114,980,781 - 5,141,022 (-)NCBISscrofa10.2Sscrofa10.2susScr3
FLT3
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.137,117,579 - 7,222,600 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl37,116,947 - 7,222,849 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366605737,168,175 - 37,271,421 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Flt3
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462477610,435,850 - 10,517,066 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462477610,407,083 - 10,516,350 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Flt3
674 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:112
Count of miRNA genes:87
Interacting mature miRNAs:95
Transcripts:ENSRNOT00000061160
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
2312418Kidm41Kidney mass QTL 413.70.0001kidney mass (VT:0002707)single kidney wet weight to body weight ratio (CMO:0000622)12592191825247790Rat
70213Niddm27Non-insulin dependent diabetes mellitus QTL 273.72blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)121120049452308831Rat
2306789Ean6Experimental allergic neuritis QTL 64.9nervous system integrity trait (VT:0010566)experimental autoimmune neuritis severity score (CMO:0001528)12129775522Rat
8552964Pigfal17Plasma insulin-like growth factor 1 level QTL 173.5blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)121120049452308831Rat
7411641Foco19Food consumption QTL 1927.70.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)121120049452308831Rat
1357337Gluco3Glucose level QTL 30.0004adipocyte glucose uptake trait (VT:0004185)absolute change in adipocyte glucose uptake (CMO:0000873)12116966671Rat
5684888Pia42Pristane induced arthritis QTL 42joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)12348941648489416Rat
1331739Hrtrt14Heart rate QTL 143.56232heart pumping trait (VT:2000009)heart rate (CMO:0000002)12138687564Rat
8552912Pigfal6Plasma insulin-like growth factor 1 level QTL 65blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)121120049752308831Rat
61331Eau2Experimental allergic uveoretinitis QTL 20.0005uvea integrity trait (VT:0010551)experimental autoimmune uveitis score (CMO:0001504)12133700600Rat
10059594Kidm46Kidney mass QTL 463.790.025kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)121174352852308831Rat
8552918Pigfal7Plasma insulin-like growth factor 1 level QTL 7blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)121120049452308831Rat
1581516Cm56Cardiac mass QTL 564.20.05heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)121186960016966542Rat
61334Gluco17Glucose level QTL 176.3adipocyte glucose uptake trait (VT:0004185)adipocyte maximal glucose uptake to basal glucose uptake ratio (CMO:0000874)12116966671Rat
2293684Bmd26Bone mineral density QTL 264.40.0002femur mineral mass (VT:0010011)total volumetric bone mineral density (CMO:0001728)12138635130Rat
6893681Bw109Body weight QTL 1092.30.004body mass (VT:0001259)body weight (CMO:0000012)12128133365Rat
1302792Scl21Serum cholesterol level QTL 213.80.0011blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)121223300030490641Rat
1300174Bw15Body weight QTL 152.93body mass (VT:0001259)body weight loss (CMO:0001399)12128606299Rat
1331787Rf41Renal function QTL 412.998kidney blood vessel physiology trait (VT:0100012)absolute change in renal blood flow rate (CMO:0001168)12133700556Rat
724526Uae3Urinary albumin excretion QTL 34.90.0001urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)12115486827Rat
1331763Wbc2White blood cell count QTL 23.162leukocyte quantity (VT:0000217)total white blood cell count (CMO:0000365)121120049452308831Rat
7204484Bp358Blood pressure QTL 3580.001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)12124849755Rat
7411547Bw129Body weight QTL 1290.001body mass (VT:0001259)body weight gain (CMO:0000420)61120049452308831Rat
7387292Kidm42Kidney mass QTL 423.030.0004kidney mass (VT:0002707)left kidney wet weight (CMO:0000083)12141361854Rat
1298081Cia25Collagen induced arthritis QTL 254.7joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)12274769447747694Rat
2303568Bw88Body weight QTL 883body mass (VT:0001259)body weight (CMO:0000012)12128606299Rat
2303575Insul14Insulin level QTL 144blood insulin amount (VT:0001560)blood insulin level (CMO:0000349)12308718048087180Rat
7411588Foco6Food consumption QTL 60.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)121120049452308831Rat
7243862Mcs30Mammary carcinoma susceptibility QTL 308.62mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)12563330650633306Rat
2293086Iddm30Insulin dependent diabetes mellitus QTL 303.82blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)12790162533938215Rat
7411597Foco10Food consumption QTL 100.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)121120049452308831Rat

Markers in Region
RH129712  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2127,699,131 - 7,699,312 (+)MAPPERmRatBN7.2
Rnor_6.0129,436,662 - 9,436,842NCBIRnor6.0
Rnor_5.01211,552,388 - 11,552,568UniSTSRnor5.0
RGSC_v3.4128,268,340 - 8,268,520UniSTSRGSC3.4
Celera129,437,415 - 9,437,595UniSTS
Cytogenetic Map12p11UniSTS
RH143417  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2127,623,655 - 7,623,812 (+)MAPPERmRatBN7.2
Rnor_6.0129,360,166 - 9,360,322NCBIRnor6.0
Rnor_5.01211,478,170 - 11,478,326UniSTSRnor5.0
Celera129,364,302 - 9,364,458UniSTS
Cytogenetic Map12p11UniSTS
BF405485  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2127,692,412 - 7,692,620 (+)MAPPERmRatBN7.2
Rnor_6.0129,429,851 - 9,430,058NCBIRnor6.0
Rnor_5.01211,545,577 - 11,545,784UniSTSRnor5.0
RGSC_v3.4128,261,379 - 8,261,586UniSTSRGSC3.4
Celera129,430,696 - 9,430,903UniSTS
RH 3.4 Map1288.01UniSTS
Cytogenetic Map12p11UniSTS
UniSTS:265488  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2127,681,890 - 7,683,447 (+)MAPPERmRatBN7.2
Rnor_6.0129,419,183 - 9,420,738NCBIRnor6.0
Rnor_5.01211,534,909 - 11,536,464UniSTSRnor5.0
RGSC_v3.4128,250,538 - 8,252,093UniSTSRGSC3.4
Celera129,420,544 - 9,422,099UniSTS
Cytogenetic Map12p11UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
9 11 47 107 91 90 59 25 59 6 214 95 11 87 43 60 31 17 17

Sequence


Ensembl Acc Id: ENSRNOT00000088957   ⟹   ENSRNOP00000069753
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1212,659,946 - 12,735,581 (+)Ensembl
mRatBN7.2 Ensembl127,623,930 - 7,699,474 (+)Ensembl
Rnor_6.0 Ensembl129,360,672 - 9,436,570 (+)Ensembl
RefSeq Acc Id: NM_001415752   ⟹   NP_001402681
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81212,660,035 - 12,735,584 (+)NCBI
mRatBN7.2127,623,930 - 7,699,474 (+)NCBI
Protein Sequences
Protein RefSeqs NP_001402681 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAM18767 (Get FASTA)   NCBI Sequence Viewer  
  EDL89562 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000069753
  ENSRNOP00000069753.2
Ensembl Acc Id: ENSRNOP00000069753   ⟸   ENSRNOT00000088957
RefSeq Acc Id: NP_001402681   ⟸   NM_001415752
- Peptide Label: precursor
- UniProtKB: A0A0G2JW59 (UniProtKB/TrEMBL),   A6K1A4 (UniProtKB/TrEMBL)
Protein Domains
Ig-like   Protein kinase

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-A0A0G2JW59-F1-model_v2 AlphaFold A0A0G2JW59 1-1002 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:61308 AgrOrtholog
BioCyc Gene G2FUF-20118 BioCyc
Ensembl Genes ENSRNOG00000054764 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000088957 ENTREZGENE
  ENSRNOT00000088957.2 UniProtKB/TrEMBL
Gene3D-CATH 2.60.40.10 UniProtKB/TrEMBL
  Phosphorylase Kinase, domain 1 UniProtKB/TrEMBL
  Transferase(Phosphotransferase) domain 1 UniProtKB/TrEMBL
InterPro Ig-like_dom UniProtKB/TrEMBL
  Ig-like_dom_sf UniProtKB/TrEMBL
  Ig-like_fold UniProtKB/TrEMBL
  Ig_sub UniProtKB/TrEMBL
  Immunoglobulin UniProtKB/TrEMBL
  Kinase-like_dom UniProtKB/TrEMBL
  Prot_kinase_cat_dom UniProtKB/TrEMBL
  Protein_kinase_ATP_BS UniProtKB/TrEMBL
  RTK UniProtKB/TrEMBL
  Ser-Thr/Tyr-Pkinase UniProtKB/TrEMBL
  Tyr_kinase_cat_dom UniProtKB/TrEMBL
  Tyr_kinase_rcpt_3_CS UniProtKB/TrEMBL
  Tyr_prot_kinase_AS UniProtKB/TrEMBL
NCBI Gene 140635 ENTREZGENE
PANTHER PTHR24416:SF356 UniProtKB/TrEMBL
  TYROSINE-PROTEIN KINASE RECEPTOR UniProtKB/TrEMBL
Pfam PF00047 UniProtKB/TrEMBL
  Pkinase_Tyr UniProtKB/TrEMBL
PhenoGen Flt3 PhenoGen
PIRSF TyrPK_CSF1-R UniProtKB/TrEMBL
PROSITE IG_LIKE UniProtKB/TrEMBL
  PROTEIN_KINASE_ATP UniProtKB/TrEMBL
  PROTEIN_KINASE_DOM UniProtKB/TrEMBL
  PROTEIN_KINASE_TYR UniProtKB/TrEMBL
  RECEPTOR_TYR_KIN_III UniProtKB/TrEMBL
RatGTEx ENSRNOG00000054764 RatGTEx
SMART SM00409 UniProtKB/TrEMBL
  TyrKc UniProtKB/TrEMBL
Superfamily-SCOP Kinase_like UniProtKB/TrEMBL
  SSF48726 UniProtKB/TrEMBL
UniProt A0A0G2JW59 ENTREZGENE, UniProtKB/TrEMBL
  A6K1A4 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2020-01-03 Flt3  Fms related receptor tyrosine kinase 3  Flt3  fms-related tyrosine kinase 3  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-09-24 Flt3  fms-related tyrosine kinase 3  Flt3  FMS-like tyrosine kinase 3  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2006-04-27 Flt3  FMS-like tyrosine kinase 3  Flt3_predicted  FMS-like tyrosine kinase 3 (predicted)  Data merged from RGD:1310673 737654 APPROVED
2005-01-12 Flt3_predicted  FMS-like tyrosine kinase 3 (predicted)      Symbol and Name status set to approved 70820 APPROVED
2002-06-10 Flt3  fms-related tyrosine kinase 3      Symbol and Name status set to approved 70585 APPROVED
2001-10-23 Flt3  fms-related tyrosine kinase 3      Name updated 68913 RESERVED