Nr2f2<sup>em1Mcwi</sup> (nuclear receptor subfamily 2, group F, member 2; zinc finger nuclease induced mutant 1, Medical College of Wisconsin) - Rat Genome Database

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Gene: Nr2f2em1Mcwi (nuclear receptor subfamily 2, group F, member 2; zinc finger nuclease induced mutant 1, Medical College of Wisconsin) Rattus norvegicus
Analyze
Symbol: Nr2f2em1Mcwi
Name: nuclear receptor subfamily 2, group F, member 2; zinc finger nuclease induced mutant 1, Medical College of Wisconsin
RGD ID: 5687721
Description: This allele was made by ZFN mutagenesis. The resulting mutation is a 15-bp in-frame deletion in exon 2 (del 600-647) resulting in a 5 amino acid deletion in the hinge region of the Nr2f2 protein, affecting protein-protein interaction with Zfpm2 (also known as Fog2).
ASSOCIATED WITH decreased urine protein level; increased ventricle muscle contractility; ASSOCIATED WITH hypertension
Type: allele  of Nr2f2  
Previously known as: Nr2f2em1Mcwi
Is Marker For: Strains:   SS-Nr2f2em1Mcwi  
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Cytogenetic Map1 RGD


Disease Annotations     Click to see Annotation Detail View
hypertension  (IMP)

Phenotype Annotations     Click to see Annotation Detail View

Mammalian Phenotype
References

References - curated
# Reference Title Reference Citation
1. Knockout rats via embryo microinjection of zinc-finger nucleases. Geurts AM, etal., Science. 2009 Jul 24;325(5939):433.
2. Mutation within the hinge region of the transcription factor Nr2f2 attenuates salt-sensitive hypertension. Kumarasamy S, etal., Nat Commun. 2015 Feb 17;6:6252. doi: 10.1038/ncomms7252.
3. PhysGen Knockouts PhysGen Knockout strains

Genomics

Allelic Variants
Name Chromosome Start Pos End Pos Reference Nucleotide Variant Nucleotide Variant Type Assembly
Nr2f2em1Mcwi-var1 chr1 124013926 124013940 CTGCCCGTGAGTAGG - deletion mRatBN7.2
Nr2f2em1Mcwi-var1 chr1 131452414 131452428 CTGCCCGTGAGTAGG - deletion Rnor_6.0

Related Rat Strains
The following Strains have been annotated to Nr2f2em1Mcwi


Expression


Sequence

Nucleotide Sequences
RefSeq Transcripts NM_080778 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles


Additional Information