Cd247<sup>em1Mcwi</sup> (Cd247 molecule; zinc finger nuclease induced mutant 1, Medical College of Wisconsin) - Rat Genome Database

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Gene: Cd247em1Mcwi (Cd247 molecule; zinc finger nuclease induced mutant 1, Medical College of Wisconsin) Rattus norvegicus
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Symbol: Cd247em1Mcwi
Name: Cd247 molecule; zinc finger nuclease induced mutant 1, Medical College of Wisconsin
RGD ID: 5687703
Description: This allele was made by ZFN mutagenesis. The resulting mutation is an 11-bp frameshift deletion in exon 1 (del 154-164)
ASSOCIATED WITH absent alpha-beta T cells; decreased B cell number; decreased mean systemic arterial blood pressure
Type: allele  of Cd247  
Previously known as: Cd247^[em1Mcwi]; Cd247em1Mcwi
Is Marker For: Strains:   SS-Cd247em1Mcwi  
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Cytogenetic Map13 RGD


References

References - curated
# Reference Title Reference Citation
1. Knockout rats via embryo microinjection of zinc-finger nucleases. Geurts AM, etal., Science. 2009 Jul 24;325(5939):433.
2. PhysGen Knockouts PhysGen Knockout strains
3. CD247 modulates blood pressure by altering T-lymphocyte infiltration in the kidney. Rudemiller N, etal., Hypertension. 2014 Mar;63(3):559-64. doi: 10.1161/HYPERTENSIONAHA.113.02191. Epub 2013 Dec 16.

Genomics

Allelic Variants
Name Chromosome Start Pos End Pos Reference Nucleotide Variant Nucleotide Variant Type Assembly
Cd247em1Mcwi-var1 chr13 78043460 78043470 TTCAAGTGCAG - deletion mRatBN7.2
Cd247em1Mcwi-var1 chr13 83996233 83996243 TTCAAGTGCAG - deletion Rnor_6.0

Related Rat Strains
The following Strains have been annotated to Cd247em1Mcwi


Expression


Sequence

Nucleotide Sequences
RefSeq Transcripts NM_170789 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles


Additional Information