Agtr1a<sup>em5Mcwi</sup> (angiotensin II receptor, type 1a; zinc finger nuclease induced mutant 5, Medical College of Wisconsin) - Rat Genome Database

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Gene: Agtr1aem5Mcwi (angiotensin II receptor, type 1a; zinc finger nuclease induced mutant 5, Medical College of Wisconsin) Rattus norvegicus
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Symbol: Agtr1aem5Mcwi
Name: angiotensin II receptor, type 1a; zinc finger nuclease induced mutant 5, Medical College of Wisconsin
RGD ID: 5508318
Description: This allele was made by ZFN mutagenesis. The resulting mutation is a 19-bp frameshift deletion in exon 3 (del 517-535)
ASSOCIATED WITH decreased angiogenesis
Type: allele  of Agtr1a  
Previously known as: Agtr1a^[em5Mcwi]; Agtr1aem5Mcwi
Is Marker For: Strains:   SS-Agtr1aem5Mcwi  
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Cytogenetic Map17 RGD


Phenotype Annotations     Click to see Annotation Detail View

Mammalian Phenotype
References

References - curated
# Reference Title Reference Citation
1. Interaction between Mas1 and AT1RA contributes to enhancement of skeletal muscle angiogenesis by angiotensin-(1-7) in Dahl salt-sensitive rats. Exner EC, etal., PLoS One. 2020 Apr 23;15(4):e0232067. doi: 10.1371/journal.pone.0232067. eCollection 2020.
2. Knockout rats via embryo microinjection of zinc-finger nucleases. Geurts AM, etal., Science. 2009 Jul 24;325(5939):433.
3. PhysGen Knockouts PhysGen Knockout strains

Genomics

Allelic Variants
Name Chromosome Start Pos End Pos Reference Nucleotide Variant Nucleotide Variant Type Assembly
Agtr1aem5Mcwi-var1 chr17 35908756 35908774 CCATAGCGGTATAGACTGC - deletion Rnor_6.0

Related Rat Strains
The following Strains have been annotated to Agtr1aem5Mcwi
SS-Agtr1aem5Mcwi    


Expression


Sequence

Nucleotide Sequences
RefSeq Transcripts NM_030985 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles


Additional Information