Plekha7<sup>em4Mcwi</sup> (pleckstrin homology domain containing, family A member 7; zinc finger nuclease induced mutant 4, Medical College of Wisconsin) - Rat Genome Database

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Gene: Plekha7em4Mcwi (pleckstrin homology domain containing, family A member 7; zinc finger nuclease induced mutant 4, Medical College of Wisconsin) Rattus norvegicus
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Symbol: Plekha7em4Mcwi
Name: pleckstrin homology domain containing, family A member 7; zinc finger nuclease induced mutant 4, Medical College of Wisconsin
RGD ID: 5143979
Description: This allele was made by ZFN mutagenesis. The resulting mutation is a 19-bp frameshift deletion in exon 8 (del 638-656)
ASSOCIATED WITH decreased susceptibility to hypertension; decreased systemic vascular resistance; decreased urine albumin level; ASSOCIATED WITH Cardiac Fibrosis; glomerulosclerosis; hypertension
Type: allele  of Plekha7  
Previously known as: Plekha7^[em4Mcwi]; Plekha7em4Mcwi
Is Marker For: Strains:   SS-Plekha7em4Mcwi   SS-Plekha7em4Mcwi-/-  
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Cytogenetic Map1 RGD


Disease Annotations     Click to see Annotation Detail View

References

References - curated
# Reference Title Reference Citation
1. Mutation of Plekha7 attenuates salt-sensitive hypertension in the rat. Endres BT, etal., Proc Natl Acad Sci U S A. 2014 Sep 2;111(35):12817-22. doi: 10.1073/pnas.1410745111. Epub 2014 Aug 18.
2. Knockout rats via embryo microinjection of zinc-finger nucleases. Geurts AM, etal., Science. 2009 Jul 24;325(5939):433.
3. PhysGen Knockouts PhysGen Knockout strains

Genomics

Allelic Variants
Name Chromosome Start Pos End Pos Reference Nucleotide Variant Nucleotide Variant Type Assembly
Plekha7em4Mcwi-var1 chr1 170420191 170420209 GTCATCTCCCCGGTGGCCC - deletion mRatBN7.2
Plekha7em4Mcwi-var1 chr1 185483638 185483656 GTCATCTCCCCGGTGGCCC - deletion Rnor_6.0

Related Rat Strains
The following Strains have been annotated to Plekha7em4Mcwi


Expression


Sequence

Nucleotide Sequences
RefSeq Transcripts NM_001144861 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles


Additional Information