Alms1<sup>em1Mcwi</sup> (Alstrom syndrome 1 homolog (human); zinc finger nuclease induced mutant 1, Medical College of Wisconsin) - Rat Genome Database

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Gene: Alms1em1Mcwi (Alstrom syndrome 1 homolog (human); zinc finger nuclease induced mutant 1, Medical College of Wisconsin) Rattus norvegicus
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Symbol: Alms1em1Mcwi
Name: Alstrom syndrome 1 homolog (human); zinc finger nuclease induced mutant 1, Medical College of Wisconsin
RGD ID: 5131906
Description: This allele was made by zinc finger nuclease mutagenesis. The resulting mutation is an 17-bp frameshift deletion in exon 1 (del 429-445).
ASSOCIATED WITH increased body weight; increased mean systemic arterial blood pressure; increased systemic arterial systolic blood pressure
Type: allele  of Alms1  
Previously known as: Alms1^[em1Mcwi]; Alms1em1Mcwi
Is Marker For: Strains:   SS-Alms1em1Mcwi   SS-Alms1em1Mcwi-/-  
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Cytogenetic Map4 RGD


References

References - curated
# Reference Title Reference Citation
1. Knockout rats via embryo microinjection of zinc-finger nucleases. Geurts AM, etal., Science. 2009 Jul 24;325(5939):433.
2. Role of Alström syndrome 1 in the regulation of blood pressure and renal function. Jaykumar AB, etal., JCI Insight. 2018 Nov 2;3(21). pii: 95076. doi: 10.1172/jci.insight.95076.
3. PhysGen Knockouts PhysGen Knockout strains

Genomics

Allelic Variants
Name Chromosome Start Pos End Pos Reference Nucleotide Variant Nucleotide Variant Type Assembly
Alms1em1Mcwi-var1 chr4 117371972 117371988 CTCCGTCCTCCCGGCAC - deletion Rnor_6.0

Related Rat Strains
The following Strains have been annotated to Alms1em1Mcwi


Expression


Sequence

Nucleotide Sequences
RefSeq Transcripts NM_001106604 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles


Additional Information