Alms1<sup>em1Mcwi</sup> (Alstrom syndrome 1 homolog (human); zinc finger nuclease induced mutant 1, Medical College of Wisconsin) - Rat Genome Database

Send us a Message



 Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   
Search RGD Grant Resources Citing RGD About Us Contact Us
Genes Community Projects (beta) QTLs Strains Markers Genome Information Ontologies Cell Lines References Download Submit Data
OntoMate (Literature Search) JBrowse (Genome Browser) Synteny Browser (VCMap)  (beta) Variant Visualizer Multi-Ontology Enrichment (MOET) Gene-Ortholog Location Finder (GOLF) InterViewer (Protein-Protein Interactions) PhenoMiner (Quatitative Phenotypes) Gene Annotator OLGA (Gene List Generator) AllianceMine GViewer (Genome Viewer)
Aging & Age-Related Disease Cancer & Neoplastic Disease Cardiovascular Disease Coronavirus Disease Developmental Disease Diabetes Hematologic Disease Immune & Inflammatory Disease Infectious Disease Liver Disease Neurological Disease Obesity & Metabolic Syndrome Renal Disease Respiratory Disease Sensory Organ Disease
Find Models   new Genetic Models Autism Models Rat PhenoMiner (Quantitative Phenotypes) Chinchilla PhenoMiner Expected Ranges (Quantitative Phenotype) PhenoMiner Term Comparison Hybrid Rat Diversity Panel Phenotypes GERRC (Gene Editing Rat Resource Center) Phenotypes in Other Animal Models Animal Husbandry Strain Medical Records Phylogenetics Strain Availability Calendar Rats 101 Submissions Photo Archive
Pathways
Rat Community Forum Directory of Rat Laboratories Video Tutorials News RGD Publications RGD Presentations Archive Nomenclature Guidelines Resource Links Laboratory Resources Employment Resources
Gene: Alms1em1Mcwi (Alstrom syndrome 1 homolog (human); zinc finger nuclease induced mutant 1, Medical College of Wisconsin) Rattus norvegicus
Analyze
Symbol: Alms1em1Mcwi
Name: Alstrom syndrome 1 homolog (human); zinc finger nuclease induced mutant 1, Medical College of Wisconsin
RGD ID: 5131906
Description: This allele was made by zinc finger nuclease mutagenesis. The resulting mutation is an 17-bp frameshift deletion in exon 1 (del 429-445).
ASSOCIATED WITH increased body weight; increased mean systemic arterial blood pressure; increased systemic arterial systolic blood pressure
Type: allele  of Alms1  
Previously known as: Alms1em1Mcwi
Is Marker For: Strains:   SS-Alms1em1Mcwi   SS-Alms1em1Mcwi-/-  
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Cytogenetic Map4 RGD


References

References - curated
# Reference Title Reference Citation
1. Knockout rats via embryo microinjection of zinc-finger nucleases. Geurts AM, etal., Science. 2009 Jul 24;325(5939):433.
2. Role of Alström syndrome 1 in the regulation of blood pressure and renal function. Jaykumar AB, etal., JCI Insight. 2018 Nov 2;3(21). pii: 95076. doi: 10.1172/jci.insight.95076.
3. PhysGen Knockouts PhysGen Knockout strains

Genomics

Allelic Variants
Name Chromosome Start Pos End Pos Reference Nucleotide Variant Nucleotide Variant Type Assembly
Alms1em1Mcwi-var1 chr4 117371972 117371988 CTCCGTCCTCCCGGCAC - deletion Rnor_6.0

Related Rat Strains
The following Strains have been annotated to Alms1em1Mcwi
SS-Alms1em1Mcwi-/-     SS-Alms1em1Mcwi    


Expression


Sequence

Nucleotide Sequences
RefSeq Transcripts NM_001106604 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles


Additional Information