Pde6b<sup>em1Baek</sup> (phosphodiesterase 6B; Cpf1-CRISPR induced mutant1, Baek)

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Gene: Pde6b^em1Baek (phosphodiesterase 6B; Cpf1-CRISPR induced mutant1, Baek) Rattus norvegicus

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Symbol:	Pde6b^em1Baek
Name:	phosphodiesterase 6B; Cpf1-CRISPR induced mutant1, Baek
RGD ID:	42721979
Description:	Cpf1-CRISPR system was injected to SD embryos to induced an 11-bp deletion in exon 1 of rat Pde6b. ASSOCIATED WITH abnormal retina blood vessel pattern; increased retina apoptosis; retina degeneration; ASSOCIATED WITH retinitis pigmentosa
Type:	allele of Pde6b
Is Marker For:	Strains: SD-Pde6b^em1Baek
Latest Assembly:	mRatBN7.2 - mRatBN7.2 Assembly
Position:	No map positions available.

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

retinitis pigmentosa (IMP)

Phenotype Annotations Click to see Annotation Detail View

Mammalian Phenotype

abnormal retina blood vessel pattern (IMP)

increased retina apoptosis (IMP)

retina degeneration (IMP)

retina outer nuclear layer degeneration (IMP)

retina photoreceptor degeneration (IMP)

thin retina outer nuclear layer (IMP)

References

References - curated

#	Reference Title	Reference Citation
1.	Development of a Pde6b Gene Knockout Rat Model for Studies of Degenerative Retinal Diseases.	Yeo JH, etal., Invest Ophthalmol Vis Sci. 2019 Apr 1;60(5):1519-1526. doi: 10.1167/iovs.18-25556.

Genomics

Related Rat Strains

The following Strains have been annotated to Pde6b^em1Baek

SD-Pde6b^em1Baek

Expression

Sequence

Nucleotide Sequences

Additional Information

Nomenclature History

Date	Current Symbol	Current Name	Previous Symbol	Previous Name	Description	Reference	Status
2021-02-25	Pde6b^em1Baek	phosphodiesterase 6B; Cpf1-CRISPR induced mutant1, Baek	Pde6b^em1Baek		Name changed	629549	APPROVED

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InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

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MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

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Mammalian Phenotype