Nek8<sup>lpkArc</sup> (NIMA-related kinase 8; lpk mutant, Arc) - Rat Genome Database

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Gene: Nek8lpkArc (NIMA-related kinase 8; lpk mutant, Arc) Rattus norvegicus
Symbol: Nek8lpkArc
Name: NIMA-related kinase 8; lpk mutant, Arc
RGD ID: 42721975
Description: The Lewis Polycystic Kidney (LPK) rat is a spontaneous mutant identified in the LEW colony (LEW/SsNArc) maintained at Animal Resources Centre in Canning Vale, WA 6970 AUSTRALIA. The causal gene is identified as a non-synonymous mutation R650C in the NIMA (never in mitosis gene a)- related kinase 8 ( Nek8) gene.
ASSOCIATED WITH increased kidney epithelial cell primary cilium length; ASSOCIATED WITH nephronophthisis 9
Type: allele  of Nek8  
Previously known as: Nek8^[lpkArc]; NIMA-related kinase 8; lpk mutant ,Arc
Is Marker For: Strains:   LEW-Nek8lpk/Arc  
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position: No map positions available.

Disease Annotations     Click to see Annotation Detail View

Phenotype Annotations     Click to see Annotation Detail View

Mammalian Phenotype

References - curated
# Reference Title Reference Citation
1. A novel mutation causing nephronophthisis in the Lewis polycystic kidney rat localises to a conserved RCC1 domain in Nek8. McCooke JK, etal., BMC Genomics. 2012 Aug 16;13:393. doi: 10.1186/1471-2164-13-393.


Related Rat Strains
The following Strains have been annotated to Nek8lpkArc



Nucleotide Sequences

Additional Information

Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2021-02-25 Nek8lpkArc  NIMA-related kinase 8; lpk mutant, Arc  Nek8lpkArc  NIMA-related kinase 8; lpk mutant ,Arc  Name changed 629549 APPROVED