Grm2<sup>em1</sup> (glutamate metabotropic receptor 2; endonuclease induced mutant 1)

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Gene: Grm2^em1 (glutamate metabotropic receptor 2; endonuclease induced mutant 1) Rattus norvegicus

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Symbol:	Grm2^em1
Name:	glutamate metabotropic receptor 2; endonuclease induced mutant 1
RGD ID:	41410882
Description:	The genome modification technology created a premature stop codon insertion that causes a nonsense mutation at amino acid C407, deleting the transmembrane and intracellular domains of the receptor and rendering the gene nonfunctional. ASSOCIATED WITH abnormal behavioral response to addictive substance; abnormal behavioral response to morphine; abnormal behavioral withdrawal response; ASSOCIATED WITH Cocaine-Related Disorders; heroin dependence
Type:	allele of Grm2
Is Marker For:	Strains: WI-Grm2^em1
Latest Assembly:	mRatBN7.2 - mRatBN7.2 Assembly
Position:	No map positions available.

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

Cocaine-Related Disorders (IMP)

heroin dependence (IMP)

Phenotype Annotations Click to see Annotation Detail View

Mammalian Phenotype

abnormal behavioral response to addictive substance (IMP)

abnormal behavioral response to morphine (IMP)

abnormal behavioral withdrawal response (IMP)

abnormal cocaine self-administration (IMP)

abnormal cue-induced reinstatement of an extinguished operant behavior for a cocaine reinforcer (IMP)

abnormal extinction of cocaine self-administration (IMP)

abnormal neurotransmitter secretion (IMP)

abnormal nocifensive behavior (IMP)

abnormal response to electrical stimuli (IMP)

addiction (IMP)

enhanced behavioral response to cocaine (IMP)

enhanced behavioral response to morphine (IMP)

enhanced behavioral response to nicotine (IMP)

high preference for an addictive substance (IMP)

increased chemically-elicited antinociception (IMP)

increased nervous system dopamine level (IMP)

increased thermal nociceptive threshold (IMP)

References

References - curated

#	Reference Title	Reference Citation
1.	Deletion of the type 2 metabotropic glutamate receptor increases heroin abuse vulnerability in transgenic rats.	Gao JT, etal., Neuropsychopharmacology. 2018 Dec;43(13):2615-2626. doi: 10.1038/s41386-018-0231-5. Epub 2018 Oct 3.
2.	Deletion of Type 2 Metabotropic Glutamate Receptor Decreases Sensitivity to Cocaine Reward in Rats.	Yang HJ, etal., Cell Rep. 2017 Jul 11;20(2):319-332. doi: 10.1016/j.celrep.2017.06.046.

Genomics

Related Rat Strains

The following Strains have been annotated to Grm2^em1

WI-Grm2^em1

Expression

Sequence

Nucleotide Sequences

Additional Information

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

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MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

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Mammalian Phenotype