Grm2<sup>em1</sup> (glutamate metabotropic receptor 2; endonuclease induced mutant 1) - Rat Genome Database

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Gene: Grm2em1 (glutamate metabotropic receptor 2; endonuclease induced mutant 1) Rattus norvegicus
Symbol: Grm2em1
Name: glutamate metabotropic receptor 2; endonuclease induced mutant 1
RGD ID: 41410882
Description: The genome modification technology created a premature stop codon insertion that causes a nonsense mutation at amino acid C407, deleting the transmembrane and intracellular domains of the receptor and rendering the gene nonfunctional.
ASSOCIATED WITH abnormal behavioral response to addictive substance; abnormal behavioral response to morphine; abnormal behavioral withdrawal response; ASSOCIATED WITH Cocaine-Related Disorders; heroin dependence
Type: allele  of Grm2  
Is Marker For: Strains:   WI-Grm2em1  
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position: No map positions available.


References - curated
# Reference Title Reference Citation
1. Deletion of the type 2 metabotropic glutamate receptor increases heroin abuse vulnerability in transgenic rats. Gao JT, etal., Neuropsychopharmacology. 2018 Dec;43(13):2615-2626. doi: 10.1038/s41386-018-0231-5. Epub 2018 Oct 3.
2. Deletion of Type 2 Metabotropic Glutamate Receptor Decreases Sensitivity to Cocaine Reward in Rats. Yang HJ, etal., Cell Rep. 2017 Jul 11;20(2):319-332. doi: 10.1016/j.celrep.2017.06.046.


Related Rat Strains
The following Strains have been annotated to Grm2em1



Nucleotide Sequences

Additional Information