Lrp5<sup>em2Vari</sup> (LDL receptor related protein 5; CRISPR/Cas9 induced mutant 2, Vari) - Rat Genome Database

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Gene: Lrp5em2Vari (LDL receptor related protein 5; CRISPR/Cas9 induced mutant 2, Vari) Rattus norvegicus
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Symbol: Lrp5em2Vari
Name: LDL receptor related protein 5; CRISPR/Cas9 induced mutant 2, Vari
RGD ID: 41404650
Description: CRISPR/Cas9 system was used to introduce a 22-bp deletion at the sgRNA2 site of exon 2 in the rat Lrp5 gene of Crl:SD embryos.
ASSOCIATED WITH abnormal femur morphology; abnormal retina blood vessel morphology; abnormal retina blood vessel pattern
Type: allele  of Lrp5  
Previously known as: LDL receptor related protein 5;CRISPR/Cas9 induced mutant 2, Vari; Lrp5^[em2Vari]
Is Marker For: Strains:   SD-Lrp5em2Vari   SD-Lrp5em2Vari/Rrrc  
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position: No map positions available.


References

References - curated
# Reference Title Reference Citation
1. Low-Density Lipoprotein Receptor-Related Protein 5-Deficient Rats Have Reduced Bone Mass and Abnormal Development of the Retinal Vasculature. Ubels JL, etal., CRISPR J. 2020 Aug;3(4):284-298. doi: 10.1089/crispr.2020.0009.

Genomics


Related Rat Strains
The following Strains have been annotated to Lrp5em2Vari


Expression


Sequence

Nucleotide Sequences


Additional Information


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2021-01-29 Lrp5em2Vari  LDL receptor related protein 5; CRISPR/Cas9 induced mutant 2, Vari  Lrp5em2Vari  LDL receptor related protein 5;CRISPR/Cas9 induced mutant 2, Vari  Name changed 629549 APPROVED