Lrp5<sup>em2Vari</sup> (LDL receptor related protein 5; CRISPR/Cas9 induced mutant 2, Vari)

	Submit Data \| Help \| Video Tutorials \| News \| Publications \| Download \| REST API \| Citing RGD \| Contact
	Search RGD Grant Resources Citing RGD About Us Contact Us Genes Community Projects (beta) QTLs Strains Markers Genome Information Ontologies Cell Lines References Download Submit Data OntoMate (Literature Search) JBrowse (Genome Browser) Synteny Browser (VCMap) (beta) Variant Visualizer Multi-Ontology Enrichment (MOET) Gene-Ortholog Location Finder (GOLF) InterViewer (Protein-Protein Interactions) PhenoMiner (Quatitative Phenotypes) Gene Annotator OLGA (Gene List Generator) AllianceMine GViewer (Genome Viewer) Aging & Age-Related Disease Cancer & Neoplastic Disease Cardiovascular Disease Coronavirus Disease Developmental Disease Diabetes Hematologic Disease Immune & Inflammatory Disease Infectious Disease Liver Disease Neurological Disease Obesity & Metabolic Syndrome Renal Disease Respiratory Disease Sensory Organ Disease Find Models new Genetic Models Autism Models Rat PhenoMiner (Quantitative Phenotypes) Chinchilla PhenoMiner Expected Ranges (Quantitative Phenotype) PhenoMiner Term Comparison Hybrid Rat Diversity Panel Phenotypes GERRC (Gene Editing Rat Resource Center) Phenotypes in Other Animal Models Animal Husbandry Strain Medical Records Phylogenetics Strain Availability Calendar Rats 101 Submissions Photo Archive Pathways Rat Community Forum Directory of Rat Laboratories Video Tutorials News RGD Publications RGD Presentations Archive Nomenclature Guidelines Resource Links Laboratory Resources Employment Resources
	Advanced Search (OLGA)

Gene: Lrp5^em2Vari (LDL receptor related protein 5; CRISPR/Cas9 induced mutant 2, Vari) Rattus norvegicus

Analyze

Symbol:	Lrp5^em2Vari
Name:	LDL receptor related protein 5; CRISPR/Cas9 induced mutant 2, Vari
RGD ID:	41404650
Description:	CRISPR/Cas9 system was used to introduce a 22-bp deletion at the sgRNA2 site of exon 2 in the rat Lrp5 gene of Crl:SD embryos. ASSOCIATED WITH abnormal femur morphology; abnormal retina blood vessel morphology; abnormal retina blood vessel pattern
Type:	allele of Lrp5
Previously known as:	LDL receptor related protein 5;CRISPR/Cas9 induced mutant 2, Vari
Is Marker For:	Strains: SD-Lrp5^em2Vari/Rrrc SD-Lrp5^em2Vari
Latest Assembly:	mRatBN7.2 - mRatBN7.2 Assembly
Position:	No map positions available.

Annotation Click to see Annotation Detail View

Phenotype Annotations Click to see Annotation Detail View

Mammalian Phenotype

abnormal femur morphology (IMP)

abnormal retina blood vessel morphology (IMP)

abnormal retina blood vessel pattern (IMP)

decreased trabecular bone mass (IMP)

decreased trabecular bone thickness (IMP)

increased bone trabecular spacing (IMP)

References

References - curated

#	Reference Title	Reference Citation
1.	Low-Density Lipoprotein Receptor-Related Protein 5-Deficient Rats Have Reduced Bone Mass and Abnormal Development of the Retinal Vasculature.	Ubels JL, etal., CRISPR J. 2020 Aug;3(4):284-298. doi: 10.1089/crispr.2020.0009.

Genomics

Related Rat Strains

The following Strains have been annotated to Lrp5^em2Vari

SD-Lrp5^em2Vari SD-Lrp5^em2Vari/Rrrc

Expression

Sequence

Nucleotide Sequences

Additional Information

Nomenclature History

Date	Current Symbol	Current Name	Previous Symbol	Previous Name	Description	Reference	Status
2021-01-29	Lrp5^em2Vari	LDL receptor related protein 5; CRISPR/Cas9 induced mutant 2, Vari	Lrp5^em2Vari	LDL receptor related protein 5;CRISPR/Cas9 induced mutant 2, Vari	Name changed	629549	APPROVED

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

Send us a Message

Mammalian Phenotype