Mmp2<sup>em2Mcwi</sup> (matrix metallopeptidase 2; zinc finger nuclease induced mutant 2, Medical College of Wisconsin) - Rat Genome Database

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Gene: Mmp2em2Mcwi (matrix metallopeptidase 2; zinc finger nuclease induced mutant 2, Medical College of Wisconsin) Rattus norvegicus
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Symbol: Mmp2em2Mcwi
Name: matrix metallopeptidase 2; zinc finger nuclease induced mutant 2, Medical College of Wisconsin
RGD ID: 4139869
Description: This allele was made by zinc finger nuclease mutagenesis. The resulting mutation is a 8-bp frameshift deletion in exon 7 (del 1433-1440).
ASSOCIATED WITH abnormal podocyte physiology; decreased circulating creatinine level; decreased kidney weight; ASSOCIATED WITH Diabetic Nephropathies; Hypertensive Nephropathy; proteinuria
Type: allele  of Mmp2  
Previously known as: Mmp2^[em2Mcwi]; Mmp2em2Mcwi
Is Marker For: Strains:   SS-Mmp2em2Mcwi   SS-Mmp2em1Mcwi-/-  
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Cytogenetic Map19 RGD


References

References - curated
# Reference Title Reference Citation
1. Knockout rats via embryo microinjection of zinc-finger nucleases. Geurts AM, etal., Science. 2009 Jul 24;325(5939):433.
2. Knockout of Matrix Metalloproteinase 2 Opposes Hypertension- and Diabetes-Induced Nephropathy. Hirata T, etal., J Cardiovasc Pharmacol. 2023 Aug 25. doi: 10.1097/FJC.0000000000001473.
3. PhysGen Knockouts PhysGen Knockout strains

Genomics

Allelic Variants
Name Chromosome Start Pos End Pos Reference Nucleotide Variant Nucleotide Variant Type Assembly
Mmp2em2Mcwi-var1 chr19 26646695 26646702 ATCATCGT - deletion Rnor_5.0

Related Rat Strains
The following Strains have been annotated to Mmp2em2Mcwi


Expression


Sequence

Nucleotide Sequences
RefSeq Transcripts NM_031054 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles


Additional Information