Nox4<sup>em2Mcwi</sup> (NADPH oxidase 4; zinc finger nuclease induced mutant 2, Medical College of Wisconsin)

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Gene: Nox4^em2Mcwi (NADPH oxidase 4; zinc finger nuclease induced mutant 2, Medical College of Wisconsin) Rattus norvegicus

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Symbol:

Nox4^em2Mcwi

Name:

NADPH oxidase 4; zinc finger nuclease induced mutant 2, Medical College of Wisconsin

RGD ID:

4139868

Description:

This allele was made by zinc finger nuclease mutagenesis. The resulting mutation is an 8-bp frameshift deletion in exon 7 (del 586-593).
ASSOCIATED WITH decreased mean systemic arterial blood pressure; decreased susceptibility to hypertension; decreased urine albumin level

Type:

allele of Nox4

Previously known as:

Nox4^[em2Mcwi]; Nox4em2Mcwi

Is Marker For:

Strains: SS-Nox4^em2Mcwi SS-Nox4^em2Mcwi-/- SS-Nox4^em2Mcwi-/+ SS-Nox4^em2Ncf2^em1Mcwi

Latest Assembly:

mRatBN7.2 - mRatBN7.2 Assembly

Position:

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Cytogenetic Map	1		RGD

Annotation Click to see Annotation Detail View

Phenotype Annotations Click to see Annotation Detail View

Mammalian Phenotype

decreased mean systemic arterial blood pressure (IMP)

decreased susceptibility to hypertension (IMP)

decreased urine albumin level (IMP)

oxidative stress (IMP)

References

References - curated

#	Reference Title	Reference Citation
1.	Evidence of the Importance of Nox4 in Production of Hypertension in Dahl Salt-Sensitive Rats.	Cowley AW Jr, etal., Hypertension. 2016 Feb;67(2):440-50. doi: 10.1161/HYPERTENSIONAHA.115.06280. Epub 2015 Dec 7.
2.	Knockout rats via embryo microinjection of zinc-finger nucleases.	Geurts AM, etal., Science. 2009 Jul 24;325(5939):433.
3.	PhysGen Knockouts	PhysGen Knockout strains
4.	Role of Nox4 and p67phox subunit of Nox2 in ROS production in response to increased tubular flow in the mTAL of Dahl salt-sensitive rats.	Zheleznova NN, etal., Am J Physiol Renal Physiol. 2016 Aug 1;311(2):F450-8. doi: 10.1152/ajprenal.00187.2016. Epub 2016 Jun 8.

Genomics

Allelic Variants

Name	Chromosome	Start Pos	End Pos	Reference Nucleotide	Variant Nucleotide	Variant Type	Assembly
Nox4em2Mcwi-var1	chr1	150861996	150862003	ACCTATGC	-	deletion	Rnor_6.0

Related Rat Strains

The following Strains have been annotated to Nox4^em2Mcwi

SS-Nox4^em2Ncf2^em1Mcwi SS-Nox4^em2Mcwi-/+ SS-Nox4^em2Mcwi-/- SS-Nox4^em2Mcwi

Expression

RNA-SEQ Expression
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Sequence

Nucleotide Sequences

RefSeq Transcripts NM_053524 (Get FASTA) NCBI Sequence Viewer Search GEO for Microarray Profiles

Additional Information

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

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MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

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Mammalian Phenotype