Rag1<sup>em2Mcwi</sup> (recombination activating gene 1; zinc finger nuclease induced mutant 2, Medical College of Wisconsin) - Rat Genome Database

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Gene: Rag1em2Mcwi (recombination activating gene 1; zinc finger nuclease induced mutant 2, Medical College of Wisconsin) Rattus norvegicus
Analyze
Symbol: Rag1em2Mcwi
Name: recombination activating gene 1; zinc finger nuclease induced mutant 2, Medical College of Wisconsin
RGD ID: 4139866
Description: This allele was made by zinc finger nuclease mutagenesis. The resulting mutation is a 17-bp frameshift deletion in exon 1 (del 687-703).
ASSOCIATED WITH decreased thymus weight; decreased urine albumin level; increased mean systemic arterial blood pressure; ASSOCIATED WITH Albuminuria
Type: allele  of Rag1  
Previously known as: Rag1em2Mcwi
Is Marker For: Strains:   SS-Rag1em2Mcwi  
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Cytogenetic Map3 RGD


Disease Annotations     Click to see Annotation Detail View
Albuminuria  (IMP)

Phenotype Annotations     Click to see Annotation Detail View

Mammalian Phenotype
References

References - curated
# Reference Title Reference Citation
1. Knockout rats via embryo microinjection of zinc-finger nucleases. Geurts AM, etal., Science. 2009 Jul 24;325(5939):433.
2. GENETIC MUTATION OF RECOMBINATION ACTIVATING GENE 1 IN DAHL SALT-SENSITIVE RATS ATTENUATES HYPERTENSION AND RENAL DAMAGE. Mattson DL, etal., Am J Physiol Regul Integr Comp Physiol. 2013 Jan 30.
3. PhysGen Strains PhysGen strains

Genomics

Allelic Variants
Name Chromosome Start Pos End Pos Reference Nucleotide Variant Nucleotide Variant Type Assembly
Rag1em2Mcwi-var1 chr3 87922895 87922911 CACTCCACGGTCACATT - deletion mRatBN7.2
Rag1em2Mcwi-var1 chr3 91212228 91212244 CACTCCACGGTCACATT - deletion Rnor_6.0

Related Rat Strains
The following Strains have been annotated to Rag1em2Mcwi
SS-Rag1em2Mcwi    


Expression


Sequence

Nucleotide Sequences
RefSeq Transcripts NM_053468 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles


Additional Information