Rpl37 (ribosomal protein L37) - Rat Genome Database

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Gene: Rpl37 (ribosomal protein L37) Rattus norvegicus
Analyze
Symbol: Rpl37 (Ensembl: ENSRNOG00000064545)
Name: ribosomal protein L37 (Ensembl:60S ribosomal protein L37)
RGD ID: 41394010
Description: Predicted to enable MDM2/MDM4 family protein binding activity and ubiquitin ligase inhibitor activity. Predicted to be a structural constituent of ribosome. Predicted to be involved in positive regulation of signal transduction by p53 class mediator. Predicted to be located in cytosolic ribosome. Predicted to be part of cytosolic large ribosomal subunit. Predicted to be active in synapse; PARTICIPATES IN ribosome biogenesis pathway; translation pathway; INTERACTS WITH 1,1,1-Trichloro-2-(o-chlorophenyl)-2-(p-chlorophenyl)ethane; 2,2',4,4'-Tetrabromodiphenyl ether; 2,3,7,8-tetrachlorodibenzodioxine.
Type: protein-coding (Ensembl: protein_coding)
RefSeq Status: VALIDATED
Previously known as: 60S ribosomal protein L37; LOC120093056
RGD Orthologs
Human
Mouse
Alliance Genes
More Info more info ...
Related Pseudogenes: Rpl37-ps2   Rpl37-ps5  
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.2254,215,352 - 54,217,429 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl254,215,469 - 54,217,442 (+)EnsemblmRatBN7.2 Ensembl
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(-)-epigallocatechin 3-gallate  (ISO)
1,1,1-Trichloro-2-(o-chlorophenyl)-2-(p-chlorophenyl)ethane  (EXP)
1,2-dimethylhydrazine  (ISO)
2,2',4,4'-Tetrabromodiphenyl ether  (EXP,ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
3-chloropropane-1,2-diol  (EXP)
4-amino-2,6-dinitrotoluene  (EXP)
5-fluorouracil  (ISO)
acetamide  (EXP)
aluminium atom  (ISO)
aluminium(0)  (ISO)
ammonium chloride  (EXP)
antirheumatic drug  (ISO)
aristolochic acid A  (ISO)
arsenite(3-)  (ISO)
arsenous acid  (ISO)
benzene  (EXP)
benzo[a]pyrene  (ISO)
benzo[a]pyrene diol epoxide I  (ISO)
bis(2-ethylhexyl) phthalate  (ISO)
bisphenol A  (EXP,ISO)
cadmium atom  (ISO)
cadmium dichloride  (ISO)
chromium(6+)  (ISO)
clofibric acid  (EXP)
copper atom  (ISO)
copper(0)  (ISO)
cylindrospermopsin  (ISO)
diarsenic trioxide  (ISO)
dibutyl phthalate  (EXP,ISO)
dioxygen  (ISO)
dorsomorphin  (ISO)
entinostat  (ISO)
epoxiconazole  (ISO)
ethyl methanesulfonate  (ISO)
fenthion  (ISO)
folic acid  (ISO)
gentamycin  (EXP)
iron atom  (ISO)
iron(0)  (ISO)
lead(0)  (ISO)
lead(2+)  (ISO)
manganese atom  (ISO)
manganese(0)  (ISO)
methidathion  (ISO)
methotrexate  (ISO)
methyl methanesulfonate  (ISO)
miconazole  (ISO)
N-nitrosodiethylamine  (EXP)
nimesulide  (EXP)
pentachlorophenol  (ISO)
phenylmercury acetate  (ISO)
pirinixic acid  (EXP)
potassium chromate  (ISO)
pregnenolone 16alpha-carbonitrile  (ISO)
SB 431542  (ISO)
succimer  (ISO)
sunitinib  (ISO)
tetrachloromethane  (EXP)
thapsigargin  (ISO)
toluene  (EXP)
trichloroethene  (EXP)
trichostatin A  (ISO)
tungsten  (ISO)
tunicamycin  (ISO)
urethane  (ISO)
valproic acid  (ISO)
vorinostat  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
Additional References at PubMed
PMID:6350292   PMID:7588717   PMID:8484768   PMID:12477932   PMID:15489334  


Genomics

Comparative Map Data
Rpl37
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.2254,215,352 - 54,217,429 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl254,215,469 - 54,217,442 (+)EnsemblmRatBN7.2 Ensembl
RPL37
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38540,825,262 - 40,835,222 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p13 Ensembl540,825,262 - 40,835,222 (-)EnsemblGRCh38hg38GRCh38
GRCh37540,825,364 - 40,835,324 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36540,867,187 - 40,871,144 (-)NCBINCBI36Build 36hg18NCBI36
Build 34540,861,119 - 40,871,144NCBI
Celera540,720,028 - 40,723,995 (-)NCBICelera
Cytogenetic Map5p13.1NCBI
HuRef540,783,034 - 40,786,991 (-)NCBIHuRef
CHM1_1540,833,530 - 40,837,487 (-)NCBICHM1_1
T2T-CHM13v2.0541,081,680 - 41,091,646 (-)NCBIT2T-CHM13v2.0
Rpl37
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39155,146,095 - 5,148,622 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl155,146,127 - 5,148,622 (+)EnsemblGRCm39 Ensembl
GRCm38155,116,613 - 5,119,140 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl155,116,645 - 5,119,140 (+)EnsemblGRCm38mm10GRCm38
MGSCv37155,066,613 - 5,069,140 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36155,063,860 - 5,066,355 (+)NCBIMGSCv36mm8
Celera154,966,731 - 4,969,258 (+)NCBICelera
Cytogenetic Map15A1NCBI

Variants

.
Variants in Rpl37
6 total Variants

QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
61355Bp36Blood pressure QTL 362.9blood pressure trait (VT:0000183)systolic blood pressure (CMO:0000004)25873687102844969Rat
10755430Coatc6Coat color QTL 60.02576coat/hair pigmentation trait (VT:0010463)pigmented ventral coat/hair area to total ventral coat/hair area ratio (CMO:0001812)21159110056591100Rat
731184Mamtr4Mammary tumor resistance QTL 40.0003mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)21649174061491740Rat
1357990Ael1Aortic elastin QTL 13.10.00091aorta elastin amount (VT:0003905)aortic elastin21907682564076825Rat
731167Glom4Glomerulus QTL 42.40.0082kidney glomerulus morphology trait (VT:0005325)count of superficial glomeruli not directly contacting the kidney surface (CMO:0001002)22030467265304672Rat
2300168Bmd47Bone mineral density QTL 476.60.0001femur mineral mass (VT:0010011)bone mineral density (CMO:0001226)22066244865662448Rat
10402051Gdil2Gastrointestinal dilation QTL 2enteric ganglion morphology trait (VT:0001045)length of intestine affected by colonic aganglionosis to total length of colon ratio (CMO:0001836)22490385374786777Rat
1302794Stl27Serum triglyceride level QTL 274.40.0001blood triglyceride amount (VT:0002644)plasma triglyceride level (CMO:0000548)225413423143657569Rat
1358894Kidm24Kidney mass QTL 244.03kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)225413423157142209Rat
1358899Kidm23Kidney mass QTL 233.88kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)225413423157142209Rat
1358901Cm38Cardiac mass QTL 382heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)225413423157142209Rat
1358904Cm39Cardiac mass QTL 392.26heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)225413423157142209Rat
1358910Kidm27Kidney mass QTL 275.77kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)225413423157142209Rat
1358911Kidm28Kidney mass QTL 285.42kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)225413423157142209Rat
1358913Cm41Cardiac mass QTL 412.73heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)225413423203928301Rat
1358917Cm42Cardiac mass QTL 422.82heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)225413423203928301Rat
1358887Bw50Body weight QTL 502.39body mass (VT:0001259)body weight (CMO:0000012)225413652157142078Rat
1358908Bw49Body weight QTL 493.36body mass (VT:0001259)body weight (CMO:0000012)225413652157142078Rat
1354617Bp240Blood pressure QTL 2404arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)22691781781754745Rat
1354617Bp240Blood pressure QTL 2404arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)22691781781754745Rat
1354617Bp240Blood pressure QTL 2404arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)22691781781754745Rat
1354603Bp243Blood pressure QTL 2433.9arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)226917817127469484Rat
2290453Scl55Serum cholesterol level QTL 552.83blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)226917817136917119Rat
9590095Sffal3Serum free fatty acids level QTL 36.780.001blood free fatty acid amount (VT:0001553)plasma free fatty acids level (CMO:0000546)22715716072157160Rat
10755434Coatc7Coat color QTL 70.04794coat/hair pigmentation trait (VT:0010463)pigmented ventral coat/hair area to total ventral coat/hair area ratio (CMO:0001812)23064806575648065Rat
10755436Coatc8Coat color QTL 80.02431coat/hair pigmentation trait (VT:0010463)pigmented ventral coat/hair area to total ventral coat/hair area ratio (CMO:0001812)23502311780023117Rat
61371Edpm1Estrogen-dependent pituitary mass QTL 140.05pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)23513484188029593Rat
70174BpQTLCluster2Blood pressure QTL cluster 24.24arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)240067944102785628Rat
70174BpQTLCluster2Blood pressure QTL cluster 24.24arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)240067944102785628Rat
70174BpQTLCluster2Blood pressure QTL cluster 24.24arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)240067944102785628Rat
70174BpQTLCluster2Blood pressure QTL cluster 24.24arterial blood pressure trait (VT:2000000)pulse pressure (CMO:0000292)240067944102785628Rat
70174BpQTLCluster2Blood pressure QTL cluster 24.24arterial blood pressure trait (VT:2000000)absolute change in mean arterial blood pressure (CMO:0000533)240067944102785628Rat
12879863Bp402Blood pressure QTL 4020.003arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)24112578956532139Rat
1300155Bp174Blood pressure QTL 1744.09arterial blood pressure trait (VT:2000000)absolute change in mean arterial blood pressure (CMO:0000533)24280460760653831Rat
2293835Kiddil5Kidney dilation QTL 53.8kidney pelvis morphology trait (VT:0004194)hydronephrosis severity score (CMO:0001208)242804607157142209Rat
2293843Kiddil6Kidney dilation QTL 63.1kidney pelvis morphology trait (VT:0004194)hydronephrosis severity score (CMO:0001208)242804607182042367Rat
1298074Bp164Blood pressure QTL 1640.003arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)242804607202447032Rat
1298085Bp165Blood pressure QTL 1650.0006arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)242804607202447032Rat
61467Bp14Blood pressure QTL 142.2arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)243154682202446871Rat
61467Bp14Blood pressure QTL 142.2arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)243154682202446871Rat
2293676Bmd19Bone mineral density QTL 1910.70.0001femur mineral mass (VT:0010011)total volumetric bone mineral density (CMO:0001728)243162366111362592Rat
2293682Bmd24Bone mineral density QTL 248.90.0001femur mineral mass (VT:0010011)cortical volumetric bone mineral density (CMO:0001730)243162366111362592Rat
2293671Bss44Bone structure and strength QTL 4410.970.0001lumbar vertebra morphology trait (VT:0010494)lumbar vertebra cortical cross-sectional area (CMO:0001690)243162366148478373Rat
631208Bw1Body weight QTL15.09mesenteric fat pad mass (VT:0010427)mesenteric fat pad weight to body weight ratio (CMO:0000654)24317101783575226Rat
1354601Slep1Serum leptin concentration QTL 15.39blood leptin amount (VT:0005667)serum leptin level (CMO:0000780)243171017184114403Rat
631266Bp132Blood pressure QTL 1320.0005arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)246123260202447032Rat
1354592Rf50Renal function QTL 503.5urine output (VT:0003620)timed urine volume (CMO:0000260)25382274774786777Rat


Expression


Sequence

Nucleotide Sequences
RefSeq Transcripts NM_001399871 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039103525 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide BC069173 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ210660 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ210874 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ217102 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ217508 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ220738 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ221250 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ221496 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ221700 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ222983 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ223019 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ223296 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ228950 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JACYVU010000066 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  X66369 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Reference Sequences
RefSeq Acc Id: ENSRNOT00000105106   ⟹   ENSRNOP00000083745
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl254,215,846 - 54,217,429 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000111432   ⟹   ENSRNOP00000082551
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl254,215,469 - 54,217,442 (+)Ensembl
RefSeq Acc Id: XM_039103525   ⟹   XP_038959453
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2254,215,352 - 54,217,429 (+)NCBI
Protein Sequences
Protein RefSeqs NP_001386800 (Get FASTA)   NCBI Sequence Viewer  
  XP_038959453 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAH69173 (Get FASTA)   NCBI Sequence Viewer  
  CAA47012 (Get FASTA)   NCBI Sequence Viewer  
  P61928 (Get FASTA)   NCBI Sequence Viewer  
Reference Sequences
RefSeq Acc Id: XP_038959453   ⟸   XM_039103525
RefSeq Acc Id: ENSRNOP00000083745   ⟸   ENSRNOT00000105106
RefSeq Acc Id: ENSRNOP00000082551   ⟸   ENSRNOT00000111432

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P61928-F1-model_v2 AlphaFold P61928 1-97 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
BioCyc Gene G2FUF-54180 BioCyc
Ensembl Genes ENSRNOG00000064545 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Protein ENSRNOP00000082551.1 UniProtKB/TrEMBL
  ENSRNOP00000083745 ENTREZGENE
  ENSRNOP00000083745.1 UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000105106 ENTREZGENE
  ENSRNOT00000105106.1 UniProtKB/TrEMBL
  ENSRNOT00000111432.1 UniProtKB/TrEMBL
Gene3D-CATH 2.20.25.30 UniProtKB/TrEMBL
InterPro Ribosomal_L37ae/L37e UniProtKB/TrEMBL
  Ribosomal_L37e UniProtKB/TrEMBL
  Ribosomal_L37e_CS UniProtKB/TrEMBL
  Ribosomal_zn-bd UniProtKB/TrEMBL
NCBI Gene LOC120093056 ENTREZGENE
Pfam Ribosomal_L37e UniProtKB/TrEMBL
PhenoGen Rpl37 PhenoGen
PROSITE RIBOSOMAL_L37E UniProtKB/TrEMBL
Superfamily-SCOP SSF57829 UniProtKB/TrEMBL
UniProt A0A8I5ZUB4_RAT UniProtKB/TrEMBL
  A0A8I5ZVW4_RAT UniProtKB/TrEMBL
  P61928 ENTREZGENE


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2022-03-17 Rpl37  ribosomal protein L37  LOC120093056  ribosomal protein L37  Symbol changed 629549 APPROVED
2021-01-27 LOC120093056  ribosomal protein L37      Symbol and Name status set to provisional 70820 PROVISIONAL