RT1-O1l1 (RT1 class Ib, locus O1 like 1) - Rat Genome Database

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Gene: RT1-O1l1 (RT1 class Ib, locus O1 like 1) Rattus norvegicus
Analyze
No known orthologs.
Symbol: RT1-O1l1
Name: RT1 class Ib, locus O1 like 1
RGD ID: 41288091
Description: Predicted to enable peptide antigen binding activity and signaling receptor binding activity. Predicted to be involved in several processes, including antigen processing and presentation of endogenous peptide antigen via MHC class I via ER pathway, TAP-independent; antigen processing and presentation of endogenous peptide antigen via MHC class Ib; and positive regulation of T cell mediated cytotoxicity. Predicted to be located in lumenal side of endoplasmic reticulum membrane and phagocytic vesicle membrane. Predicted to be part of MHC class I protein complex. Predicted to be active in external side of plasma membrane and extracellular space.
Type: protein-coding
RefSeq Status: MODEL
Previously known as: H-2 class I histocompatibility antigen, Q7 alpha chain-like; H-2 class I histocompatibility antigen, Q9 alpha chain-like; LOC120093125
RGD Orthologs
Alliance Orthologs
More Info homologs ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8202,627,434 - 2,664,895 (+)NCBIGRCr8
mRatBN7.2202,624,073 - 2,658,023 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl202,623,953 - 2,692,081 (+)EnsemblmRatBN7.2 Ensembl
Cytogenetic Map20p12NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.

Genomics

Variants

.
Variants in RT1-O1l1
531 total Variants

QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
61472Aia1Adjuvant induced arthritis QTL 1180.001joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)2026463954597031Rat
2306850Pia40Pristane induced arthritis QTL 400.0001joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)2015279595304575Rat
1641915Colcr9Colorectal carcinoma resistance QTL 92.970.0024intestine integrity trait (VT:0010554)benign colorectal tumor number (CMO:0001795)20153065546530655Rat
7387283Uae44Urinary albumin excretion QTL 440.1712urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)20126123605Rat
7411668Foco32Food consumption QTL 3280.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)20136600972Rat
2305926Iddm37Insulin dependent diabetes mellitus QTL 376blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)20152784246527842Rat
1354642Despr15Despair related QTL 150.0027locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)20124159021Rat
1600382Edcs3Endometrial carcinoma susceptibility QTL33.50.003uterus morphology trait (VT:0001120)percentage of study population developing endometrioid carcinoma during a period of time (CMO:0001759)20125159026Rat
61448Ciaa1CIA Autoantibody QTL 1300.001blood autoantibody amount (VT:0003725)calculated serum anti-rat type 2 collagen autoantibody titer (CMO:0001281)2026463954597031Rat
8694189Bw153Body weight QTL 1533.130.001body mass (VT:0001259)body weight gain (CMO:0000420)20129191651Rat
724519Bp144Blood pressure QTL 1440.001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)2013624629Rat
9590109Sffal8Serum free fatty acids level QTL 85.320.01blood free fatty acid amount (VT:0001553)plasma free fatty acids level (CMO:0000546)20129191651Rat
9590275Scort15Serum corticosterone level QTL 153.480.001blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)20129191651Rat
9589155Insul32Insulin level QTL 326.380.001blood insulin amount (VT:0001560)plasma insulin level (CMO:0000342)20129191651Rat
7411650Foco23Food consumption QTL 2320.70.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)20129191651Rat
2317851Alcrsp22Alcohol response QTL 223.20.05response to alcohol trait (VT:0010489)duration of loss of righting reflex (CMO:0002289)20127339237Rat
1598816Memor12Memory QTL 122.4exploratory behavior trait (VT:0010471)average horizontal distance between subject and target during voluntary locomotion in an experimental apparatus (CMO:0002674)20260683647606836Rat
1641893Alcrsp7Alcohol response QTL 7response to alcohol trait (VT:0010489)duration of loss of righting reflex (CMO:0002289)20127339237Rat
6893685Bw111Body weight QTL 1112.70.004body mass (VT:0001259)body weight (CMO:0000012)20132578807Rat
9590252Scort12Serum corticosterone level QTL 1220.460.001blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)20136600972Rat


Expression

RNA-SEQ Expression


Sequence


RefSeq Acc Id: XM_039099255   ⟹   XP_038955183
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8202,627,434 - 2,631,799 (+)NCBI
mRatBN7.2202,624,073 - 2,626,979 (+)NCBI
RefSeq Acc Id: XM_039099256   ⟹   XP_038955184
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8202,627,434 - 2,640,738 (+)NCBI
mRatBN7.2202,624,073 - 2,636,874 (+)NCBI
RefSeq Acc Id: XM_039099257   ⟹   XP_038955185
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8202,627,434 - 2,664,895 (+)NCBI
mRatBN7.2202,624,073 - 2,658,023 (+)NCBI
Protein Sequences
Protein RefSeqs XP_038955183 (Get FASTA)   NCBI Sequence Viewer  
  XP_038955184 (Get FASTA)   NCBI Sequence Viewer  
  XP_038955185 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000049460.5
  ENSRNOP00000051211.5
  ENSRNOP00000105343
RefSeq Acc Id: XP_038955185   ⟸   XM_039099257
- UniProtKB: A0A8J8Y6P7 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038955184   ⟸   XM_039099256
- UniProtKB: A0A8J8Y6P7 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038955183   ⟸   XM_039099255
- UniProtKB: A0A8J8Y6P7 (UniProtKB/TrEMBL)
Protein Domains
Ig-like

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
BioCyc Gene G2FUF-4825 BioCyc
Ensembl Genes ENSRNOG00000031607 Ensembl, UniProtKB/TrEMBL
  ENSRNOG00000082801 ENTREZGENE
Ensembl Transcript ENSRNOT00000036147 ENTREZGENE
  ENSRNOT00000048535.5 UniProtKB/TrEMBL
  ENSRNOT00000050099.7 UniProtKB/TrEMBL
Gene3D-CATH 2.60.40.10 UniProtKB/TrEMBL
  3.30.500.10 UniProtKB/TrEMBL
InterPro Ig-like_dom UniProtKB/TrEMBL
  Ig-like_dom_sf UniProtKB/TrEMBL
  Ig-like_fold UniProtKB/TrEMBL
  Ig/MHC_CS UniProtKB/TrEMBL
  Ig_C1-set UniProtKB/TrEMBL
  MHC_class-I_related UniProtKB/TrEMBL
  MHC_I-like_Ag-recog UniProtKB/TrEMBL
  MHC_I-like_Ag-recog_sf UniProtKB/TrEMBL
  MHC_I/II-like_Ag-recog UniProtKB/TrEMBL
  MHC_I_a_a1/a2 UniProtKB/TrEMBL
  MHC_I_a_C UniProtKB/TrEMBL
NCBI Gene LOC120093125 ENTREZGENE
PANTHER MHC CLASS I-RELATED UniProtKB/TrEMBL
  MHC CLASS IB T9-RELATED UniProtKB/TrEMBL
Pfam C1-set UniProtKB/TrEMBL
  MHC_I UniProtKB/TrEMBL
  MHC_I_C UniProtKB/TrEMBL
PhenoGen RT1-O1l1 PhenoGen
PRINTS MHCCLASSI UniProtKB/TrEMBL
PROSITE IG_LIKE UniProtKB/TrEMBL
  IG_MHC UniProtKB/TrEMBL
RatGTEx ENSRNOG00000031607 RatGTEx
  ENSRNOG00000082801 RatGTEx
SMART IGc1 UniProtKB/TrEMBL
Superfamily-SCOP SSF48726 UniProtKB/TrEMBL
  SSF54452 UniProtKB/TrEMBL
UniProt A0A8J8Y6P7 ENTREZGENE, UniProtKB/TrEMBL
  F1M115_RAT UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2023-09-19 RT1-O1l1  RT1 class Ib, locus O1 like 1  LOC120093125  H-2 class I histocompatibility antigen, Q7 alpha chain-like  Symbol and Name Changed 1299863 APPROVED
2021-01-27 LOC120093125  H-2 class I histocompatibility antigen, Q7 alpha chain-like      Symbol and Name status set to provisional 70820 PROVISIONAL