Esr2<sup><i>em1Soar</i></sup> (estrogen receptor 2; ZFN induced mutant 1, Soar)

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Gene: Esr2^em1Soar (estrogen receptor 2; ZFN induced mutant 1, Soar) Rattus norvegicus

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Symbol:	Esr2^em1Soar
Name:	estrogen receptor 2; ZFN induced mutant 1, Soar
RGD ID:	40902840
Description:	Zinc finger nuclease targeting of exon 4 of the rat estrogen receptor-2 gene resulting in the deletion of exon 4 ASSOCIATED WITH abnormal circulating androgen level; abnormal proestrus; absent corpus luteum; ASSOCIATED WITH Female Infertility
Type:	allele of Esr2
Is Marker For:	Strains: SD-Esr2^em1Soar
Latest Assembly:	mRatBN7.2 - mRatBN7.2 Assembly
Position:	No map positions available.

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

Female Infertility (IMP)

Phenotype Annotations Click to see Annotation Detail View

Mammalian Phenotype

abnormal circulating androgen level (IMP)

abnormal proestrus (IMP)

absent corpus luteum (IMP)

absent oocytes (IMP)

anovulation (IMP)

decreased circulating estradiol level (IMP)

decreased circulating follicle stimulating hormone level (IMP)

decreased circulating luteinizing hormone level (IMP)

decreased circulating progesterone level (IMP)

decreased ovary weight (IMP)

decreased uterus weight (IMP)

female infertility (IMP)

ovary hypoplasia (IMP)

References

References - curated

#	Reference Title	Reference Citation
1.	ESR2 regulates granulosa cell genes essential for follicle maturation and ovulation.	Khristi V, etal., Mol Cell Endocrinol. 2018 Oct 15;474:214-226. doi: 10.1016/j.mce.2018.03.012. Epub 2018 Mar 24.
2.	Defining the Role of Estrogen Receptor β in the Regulation of Female Fertility.	Rumi MAK, etal., Endocrinology. 2017 Jul 1;158(7):2330-2343. doi: 10.1210/en.2016-1916.

Genomics

Related Rat Strains

The following Strains have been annotated to Esr2^em1Soar

SD-Esr2^em1Soar

Expression

Sequence

Nucleotide Sequences

Additional Information

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
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MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

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Mammalian Phenotype