Mertk<sup><i>rdy</i></sup> (MER proto-oncogene, tyrosine kinase; retinal dystrophy mutant) - Rat Genome Database

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Gene: Mertkrdy (MER proto-oncogene, tyrosine kinase; retinal dystrophy mutant) Rattus norvegicus
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Symbol: Mertkrdy
Name: MER proto-oncogene, tyrosine kinase; retinal dystrophy mutant
RGD ID: 40902839
Description: A small deletion of DNA that disrupts the gene encoding the receptor tyrosine kinase Mertk was detected in the retinal dystrophy RCS/LavRrrc. The deletion includes the splice acceptor site upstream of the second coding exon of Mertk and results in a shortened transcript that lacks this exon. The aberrant transcript joins the first and third coding exons, leading to a frameshift and a translation termination signal 20 codons after the AUG.
ASSOCIATED WITH abnormal retina pigment epithelium morphology; retina photoreceptor degeneration; thin retina outer nuclear layer; ASSOCIATED WITH retinal degeneration
Type: allele  of Mertk  
Is Marker For: Strains:   RCS/Kyo   RCS-Mertkrdyp/LavJcl  
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position: No map positions available.


Disease Annotations     Click to see Annotation Detail View

Phenotype Annotations     Click to see Annotation Detail View

Mammalian Phenotype
References

References - curated
# Reference Title Reference Citation
1. Mutation of the receptor tyrosine kinase gene Mertk in the retinal dystrophic RCS rat. D'Cruz PM, etal., Hum Mol Genet 2000 Mar 1;9(4):645-51.
2. Correction of the retinal dystrophy phenotype of the RCS rat by viral gene transfer of Mertk. Vollrath D, etal., Proc Natl Acad Sci U S A 2001 Oct 23;98(22):12584-9.

Genomics


Related Rat Strains
The following Strains have been annotated to Mertkrdy


Expression


Sequence

Nucleotide Sequences


Additional Information