Umod (uromodulin) - Rat Genome Database

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Gene: Umod (uromodulin) Rattus norvegicus
Analyze
Symbol: Umod
Name: uromodulin
RGD ID: 3940
Description: Predicted to enable IgG binding activity. Predicted to be involved in several processes, including defense response to bacterium; heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules; and metanephric nephron tubule development. Predicted to act upstream of or within with a positive effect on protein phosphorylation. Predicted to act upstream of or within several processes, including citric acid secretion; intracellular monoatomic cation homeostasis; and kidney development. Located in apical part of cell and extracellular space. Human ortholog(s) of this gene implicated in autosomal dominant tubulointerstitial kidney disease 1. Orthologous to human UMOD (uromodulin); INTERACTS WITH 6-propyl-2-thiouracil; acrylamide; acrylic acid.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: tamm-Horsfall urinary glycoprotein; THP; Urmodulin (Tamm-Horsfall protein)
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Allele / Splice: Umodem1Mcwi
Genetic Models: SS-Umodem1Mcwi
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81183,247,676 - 183,261,665 (-)NCBIGRCr8
GRCr8 Ensembl1183,247,674 - 183,261,030 (-)EnsemblGRCr8 Ensembl
mRatBN7.21173,816,341 - 173,829,681 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1173,816,339 - 173,830,302 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1182,127,287 - 182,141,005 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01189,313,389 - 189,327,107 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01182,048,615 - 182,062,333 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01189,186,027 - 189,199,939 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1189,186,026 - 189,199,376 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01196,127,939 - 196,141,822 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41177,729,212 - 177,742,552 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera1171,569,071 - 171,582,409 (-)NCBICelera
RGSC_v3.11177,868,457 - 177,881,798 (-)NCBI
Cytogenetic Map1q35NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
antibacterial innate immune response  (IEA,ISO,ISS)
apoptotic process  (IEA,ISO)
apoptotic signaling pathway  (IEA,ISO)
autophagy  (IEA,ISO)
calcium ion homeostasis  (IEA,ISO)
cellular response to stress  (IEA,ISO)
cellular response to unfolded protein  (IEA,ISO)
chemical homeostasis  (IEA,ISO)
chloride ion homeostasis  (IEA,ISO)
citric acid secretion  (IEA,ISO)
collecting duct development  (IEA,ISO)
connective tissue replacement  (IEA,ISO)
defense response to Gram-negative bacterium  (IEA,ISO,ISS)
endoplasmic reticulum organization  (IEA,ISO)
ERAD pathway  (IEA,ISO)
gene expression  (IEA,ISO)
glomerular filtration  (IEA,ISO)
heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules  (IEA,ISO)
immune system process  (IEA)
inflammatory response  (IEA,ISO)
innate immune response  (IEA)
intracellular calcium ion homeostasis  (IEA,ISO)
intracellular chloride ion homeostasis  (IEA,ISO)
intracellular phosphate ion homeostasis  (IEA,ISO)
intracellular sodium ion homeostasis  (IEA,ISO)
juxtaglomerular apparatus development  (IEA,ISO)
kidney development  (IEA,ISO)
leukocyte cell-cell adhesion  (IEA,ISO)
lipid metabolic process  (IEA,ISO)
loop of Henle development  (IEA,ISO)
metanephric ascending thin limb development  (IEA,ISO)
metanephric distal convoluted tubule development  (IEA,ISO)
metanephric thick ascending limb development  (IEA,ISO)
micturition  (IEA,ISO)
monoatomic ion homeostasis  (IEA,ISO)
multicellular organismal response to stress  (IEA,ISO)
multicellular organismal-level homeostasis  (IEA,ISO)
multicellular organismal-level water homeostasis  (IEA,ISO)
neutrophil migration  (IBA,IEA,ISO)
organ or tissue specific immune response  (IEA,ISO)
peptidyl-threonine phosphorylation  (ISO)
phosphate ion homeostasis  (IEA,ISO)
potassium ion homeostasis  (IEA,ISO)
protein folding  (ISO)
protein localization to vacuole  (IEA,ISO)
protein phosphorylation  (ISO)
protein transport into plasma membrane raft  (IEA,ISO)
regulation of blood pressure  (IEA,ISO)
regulation of protein transport  (IEA,ISO)
regulation of urine volume  (IEA,ISO)
renal sodium ion absorption  (IEA,ISO)
renal urate salt excretion  (IEA,ISO)
renal water homeostasis  (IEA,ISO)
response to endoplasmic reticulum stress  (IEA,ISO)
response to lipopolysaccharide  (IEA,ISO)
response to unfolded protein  (IEA,ISO)
response to water deprivation  (IEA,ISO)
response to xenobiotic stimulus  (IEA,ISO)
RNA splicing  (IEA,ISO)
sodium ion homeostasis  (IEA,ISO)
tumor necrosis factor-mediated signaling pathway  (IEA,ISO)
urate transport  (IEA,ISO)
urea transmembrane transport  (IEA,ISO)

Cellular Component
apical part of cell  (IDA,IEA)
apical plasma membrane  (IBA,IEA,ISO,ISS)
basolateral plasma membrane  (IEA,ISO,ISS)
cell projection  (IEA)
cell surface  (IBA)
ciliary membrane  (IEA)
cilium  (IEA,ISO,ISS)
endoplasmic reticulum  (IEA,ISO)
extracellular region  (IEA)
extracellular space  (IBA,IDA,IEA,ISO)
membrane  (IEA,ISO,ISS)
plasma membrane  (IEA,ISO)
side of membrane  (IEA)
spindle pole  (IEA,ISO,ISS)

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Ultrastructural localization of Tamm-Horsfall glycoprotein (THP) in rat kidney as revealed by protein A-gold immunocytochemistry. Bachmann S, etal., Histochemistry. 1985;83(6):531-8.
2. GP-2/THP gene family encodes self-binding glycosylphosphatidylinositol-anchored proteins in apical secretory compartments of pancreas and kidney. Fukuoka S, etal., Proc Natl Acad Sci U S A 1992 Feb 15;89(4):1189-93.
3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
4. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
5. Mutations of the UMOD gene are responsible for medullary cystic kidney disease 2 and familial juvenile hyperuricaemic nephropathy. Hart TC, etal., J Med Genet 2002 Dec;39(12):882-92.
6. Rapid isolation of tissue-specific genes from rat kidney. Hu E, etal., Exp Nephrol 2001 Mar-Apr;9(2):156-64.
7. Vitamin E attenuates crystal formation in rat kidneys: roles of renal tubular cell death and crystallization inhibitors. Huang HS, etal., Kidney Int. 2006 Aug;70(4):699-710.
8. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
9. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
10. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
11. GOA pipeline RGD automated data pipeline
12. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
13. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
14. Comprehensive gene review and curation RGD comprehensive gene curation
15. Selectively reduced expression of thick ascending limb Tamm-Horsfall protein in hypothyroid kidneys. Schmitt R, etal., Histochem Cell Biol 2004 Apr;121(4):319-27. Epub 2004 Mar 9.
16. Liver-specific ZP domain-containing protein (LZP) as a new partner of Tamm-Horsfall protein harbors on renal tubules. Shen HL, etal., Mol Cell Biochem. 2009 Jan;321(1-2):73-83. Epub 2008 Oct 2.
17. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, etal., Proc Natl Acad Sci U S A. 2002 Dec 24;99(26):16899-903. Epub 2002 Dec 11.
18. Increased tubuloglomerular feedback reactivity is associated with increased NO production in the streptozotocin-diabetic rat. Thorup C, etal., J Diabetes Complications. 2000 Jan-Feb;14(1):46-52.
19. Role of lipid rafts in membrane delivery of renal epithelial Na+-K+-ATPase, thick ascending limb. Welker P, etal., Am J Physiol Regul Integr Comp Physiol. 2007 Mar;292(3):R1328-37. Epub 2006 Nov 2.
20. Bovine and rodent tamm-horsfall protein (THP) genes: cloning, structural analysis, and promoter identification. Yu H, etal., Gene Expr 1994;4(1-2):63-75.
Additional References at PubMed
PMID:2249987   PMID:7028707   PMID:14665435   PMID:14871399   PMID:15327412   PMID:15489334   PMID:15522986   PMID:15992786   PMID:17264314   PMID:17634395   PMID:17898038   PMID:18025791  
PMID:18618131   PMID:19056867   PMID:20172860   PMID:20591941   PMID:20798515   PMID:21397062   PMID:21737451   PMID:22237754   PMID:23376485   PMID:23533145   PMID:28348009   PMID:28785050  
PMID:28990932   PMID:29145399  


Genomics

Comparative Map Data
Umod
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81183,247,676 - 183,261,665 (-)NCBIGRCr8
GRCr8 Ensembl1183,247,674 - 183,261,030 (-)EnsemblGRCr8 Ensembl
mRatBN7.21173,816,341 - 173,829,681 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1173,816,339 - 173,830,302 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1182,127,287 - 182,141,005 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01189,313,389 - 189,327,107 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01182,048,615 - 182,062,333 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01189,186,027 - 189,199,939 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1189,186,026 - 189,199,376 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01196,127,939 - 196,141,822 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41177,729,212 - 177,742,552 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera1171,569,071 - 171,582,409 (-)NCBICelera
RGSC_v3.11177,868,457 - 177,881,798 (-)NCBI
Cytogenetic Map1q35NCBI
UMOD
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381620,333,051 - 20,356,301 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1620,333,051 - 20,356,301 (-)EnsemblGRCh38hg38GRCh38
GRCh371620,344,373 - 20,364,037 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361620,251,874 - 20,271,538 (-)NCBINCBI36Build 36hg18NCBI36
Build 341620,251,874 - 20,271,538NCBI
Celera1619,493,555 - 19,513,244 (-)NCBICelera
Cytogenetic Map16p12.3NCBI
HuRef1618,881,007 - 18,900,856 (-)NCBIHuRef
CHM1_11620,432,269 - 20,452,397 (-)NCBICHM1_1
T2T-CHM13v2.01620,264,004 - 20,287,315 (-)NCBIT2T-CHM13v2.0
Umod
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm397119,061,931 - 119,078,485 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl7119,061,934 - 119,078,505 (-)EnsemblGRCm39 Ensembl
GRCm387119,462,708 - 119,479,262 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl7119,462,711 - 119,479,282 (-)EnsemblGRCm38mm10GRCm38
MGSCv377126,606,380 - 126,622,769 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv367119,254,013 - 119,270,404 (-)NCBIMGSCv36mm8
Celera7119,386,384 - 119,402,859 (-)NCBICelera
Cytogenetic Map7F2NCBI
cM Map763.88NCBI
Umod
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554423,985,308 - 3,999,598 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049554423,986,936 - 4,001,155 (-)NCBIChiLan1.0ChiLan1.0
UMOD
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21821,594,038 - 21,613,794 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11626,115,698 - 26,135,439 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01617,960,456 - 17,980,338 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11620,429,822 - 20,449,266 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1620,430,085 - 20,449,121 (-)Ensemblpanpan1.1panPan2
UMOD
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1624,991,459 - 25,006,735 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl624,991,459 - 25,006,735 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha626,355,935 - 26,369,584 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0625,145,508 - 25,160,864 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl625,145,508 - 25,160,864 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1624,946,350 - 24,961,702 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0624,841,732 - 24,857,098 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0625,229,622 - 25,244,770 (+)NCBIUU_Cfam_GSD_1.0
Umod
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024409344117,735,331 - 117,748,196 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365015,833,391 - 5,846,164 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049365015,833,391 - 5,846,021 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
UMOD
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl325,473,162 - 25,492,278 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1325,473,048 - 25,492,286 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2326,195,083 - 26,205,810 (-)NCBISscrofa10.2Sscrofa10.2susScr3
UMOD
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1518,620,927 - 18,641,312 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl518,619,895 - 18,638,719 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366606811,265,375 - 11,285,094 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Umod
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247823,640,214 - 3,652,324 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046247823,639,955 - 3,654,026 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Umod
57 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:63
Count of miRNA genes:61
Interacting mature miRNAs:63
Transcripts:ENSRNOT00000021027
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1578778Pur4Proteinuria QTL 43.30.003urine total protein amount (VT:0000032)urine total protein excretion rate (CMO:0000756)1160111531262090437Rat
1354646Kidm18Kidney mass QTL 185.7kidney mass (VT:0002707)calculated kidney weight (CMO:0000160)1160573753266453731Rat
2302378Insul11Insulin level QTL 113.25blood insulin amount (VT:0001560)serum insulin level (CMO:0000358)1153679879198679879Rat
1354653Despr9Despair related QTL 90.00019locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)1177339686222339686Rat
1578770Stresp23Stress response QTL 23kidney sympathetic nerve activity (VT:0004050)stimulated renal sympathetic nerve activity to basal renal sympathetic nerve activity ratio (CMO:0001786)1132760429191848948Rat
2293673Bss27Bone structure and strength QTL 2718.630.0001femur morphology trait (VT:0000559)femur midshaft cortical cross-sectional area (CMO:0001663)1181059071226059071Rat
61326Eae6Experimental allergic encephalomyelitis QTL 65.3body mass (VT:0001259)change in body weight (CMO:0002045)1182383862191260518Rat
2293677Bss41Bone structure and strength QTL 419.380.0001lumbar vertebra size trait (VT:0010518)lumbar vertebra cross-sectional area (CMO:0001689)1181059071226059071Rat
70160Bw18Body weight QTL 185.7body mass (VT:0001259)body weight (CMO:0000012)1153679879205813246Rat
1549830Bss1Bone structure and strength QTL 14.8femur strength trait (VT:0010010)femur ultimate force (CMO:0001675)1182039247227039247Rat
8694166Bw147Body weight QTL 1476.830.001body mass (VT:0001259)body weight gain (CMO:0000420)1153788989198788989Rat
1600397Edcs4Endometrial carcinoma susceptibility QTL 42.2uterus morphology trait (VT:0001120)percentage of study population developing endometrioid carcinoma during a period of time (CMO:0001759)1176288899270518180Rat
1354636Lmblg1Limb length QTL 16.4tibia length (VT:0004357)tibia length (CMO:0000450)1160573753210707719Rat
1549837Hcar15Hepatocarcinoma resistance QTL 150.05liver integrity trait (VT:0010547)liver tumorous lesion number (CMO:0001068)1162548015270518180Rat
2293689Bss47Bone structure and strength QTL 477.250.0001lumbar vertebra size trait (VT:0010518)lumbar vertebra trabecular cross-sectional area (CMO:0001692)1181059071226059071Rat
152025235Bw194Body weight QTL 1944.86body mass (VT:0001259)1132966869252856240Rat
61341Bp26Blood pressure QTL 26arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1139442053223964440Rat
1598853Memor3Memory QTL 34.5exploratory behavior trait (VT:0010471)total horizontal distance resulting from voluntary locomotion in an experimental apparatus (CMO:0001443)1152919152268496042Rat
1354634Kidm12Kidney mass QTL 123.9kidney mass (VT:0002707)right kidney wet weight (CMO:0000082)1160573753210707719Rat
4889428Stresp24Stress response QTL 240.05heart pumping trait (VT:2000009)absolute change in electrocardiographic low frequency R-R spectral component to high frequency R-R spectral component ratio (CMO:0002162)1165278545210278545Rat
152025232Bw192Body weight QTL 1923.93body mass (VT:0001259)1127329268206393015Rat
1578759Uae30Urinary albumin excretion QTL 303.30.003urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)1160111531262090437Rat
61343Bp28Blood pressure QTL 28arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1161077990206077990Rat
2293693Bss22Bone structure and strength QTL 2233.520.0001femur morphology trait (VT:0000559)femur cross-sectional area (CMO:0001661)1181059071226059071Rat
1358902Bw47Body weight QTL 471.67body mass (VT:0001259)body weight (CMO:0000012)199645382221502378Rat
2300161Bmd43Bone mineral density QTL 438.40.0001femur mineral mass (VT:0010011)volumetric bone mineral density (CMO:0001553)1181059071226059071Rat
61347Bp197Blood pressure QTL 1974.2arterial blood pressure trait (VT:2000000)blood pressure measurement (CMO:0000003)1168063662213063662Rat
61348Bp30Blood pressure QTL 302.4arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1159894717207261263Rat
8655649Arrd1Age-related retinal degeneration QTL 14.89retinal layer morphology trait (VT:0003727)percentage of study population developing retinopathy during a period of time (CMO:0002453)1109493780193400781Rat
2303622Vencon6Ventilatory control QTL 60.001respiration trait (VT:0001943)respiration rate (CMO:0000289)1163992710208992710Rat
631214Bw61Body weight QTL613.40.0001intramuscular adipose amount (VT:0010044)intramuscular fat area (CMO:0001162)1182535316227535316Rat
7771612Cm80Cardiac mass QTL 808.4heart left ventricle mass (VT:0007031)heart left ventricle weight (CMO:0000776)1146080545243492863Rat
731168Bp154Blood pressure QTL 1543.4arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1103779152223964440Rat
631205Bp196Blood pressure QTL 19640.0001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)198879955208479939Rat
1300158Bp173Blood pressure QTL 1733.48arterial blood pressure trait (VT:2000000)blood pressure time series experimental set point of the baroreceptor response (CMO:0002593)1155359438194575574Rat
2300174Bmd42Bone mineral density QTL 428.40.0001lumbar vertebra mineral mass (VT:0010511)bone mineral density (CMO:0001226)1181059071226059071Rat
631206Niddm40Non-insulin dependent diabetes mellitus QTL 40blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)1140833106185833106Rat
737828Hcas3Hepatocarcinoma susceptibility QTL 34.9liver integrity trait (VT:0010547)liver tumorous lesion volume to total liver volume ratio (CMO:0001082)1153679879232414077Rat
1354661Bw33Body weight QTL 335.2body mass (VT:0001259)body weight (CMO:0000012)1160573753266453731Rat
1358886Bp260Blood pressure QTL 2603.67arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)1160574007235238518Rat
1331751Bp199Blood pressure QTL 1993.60022arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)1116099376191260518Rat
2293654Bss30Bone structure and strength QTL 3032.650.0001femur strength trait (VT:0010010)femur midshaft polar moment of inertia (CMO:0001669)1181059071226059071Rat
724531Uae5Urinary albumin excretion QTL 54urine albumin amount (VT:0002871)urine albumin level (CMO:0000130)1160111426262090599Rat
2300187Bmd41Bone mineral density QTL 418.90.0001femur mineral mass (VT:0010011)volumetric bone mineral density (CMO:0001553)1181059071226059071Rat
1641895Bp298Blood pressure QTL 298arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)1132760429191848948Rat
1354580Scort1Serum corticosterone level QTL 13.4blood corticosterone amount (VT:0005345)blood corticosterone level (CMO:0001172)1154961463266453731Rat
70209Niddm23Non-insulin dependent diabetes mellitus QTL 232.82blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)1162753891207753891Rat
1358294Bw37Body weight QTL 3750.000011body mass (VT:0001259)body weight (CMO:0000012)1180739993225739993Rat
634314Niddm44Non-insulin dependent diabetes mellitus QTL 44blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)151941022208479811Rat
61379Bp44Blood pressure QTL 4419.2arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1153680016183564652Rat
2312420Pur17Proteinuria QTL 177.10.0001urine protein amount (VT:0005160)urine total protein excretion rate (CMO:0000756)1172718770228180370Rat
6893347Bw98Body weight QTL 980.20.53body mass (VT:0001259)body weight (CMO:0000012)1143092939188092939Rat
1354591Cm36Cardiac mass QTL 364.1heart left ventricle mass (VT:0007031)calculated heart weight (CMO:0000073)1111949780210707719Rat
2312558Glom17Glomerulus QTL 173.90.001kidney glomerulus morphology trait (VT:0005325)index of glomerular damage (CMO:0001135)1175967553200707874Rat
10059597Bp377Blood pressure QTL 3773.420.025arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)134565911208798288Rat
631519Pia11Pristane induced arthritis QTL 115.3joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)193903998191260518Rat
619614Bp78Blood pressure QTL 780.001arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)1178547286206690557Rat
6893361Bw104Body weight QTL 1040.590.27body mass (VT:0001259)body weight (CMO:0000012)1143092939188092939Rat
724562Rends1Renal damage susceptibility QTL 10.05kidney glomerulus integrity trait (VT:0010546)index of glomerular damage (CMO:0001135)1139442053223964440Rat
738006Anxrr14Anxiety related response QTL 1440.00035locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)1140048073185048073Rat
1558645Bw55Body weight QTL 553.20.004body mass (VT:0001259)body weight (CMO:0000012)1143092939188092939Rat
1354615Cm32Cardiac mass QTL 325.2heart left ventricle mass (VT:0007031)heart left ventricle wet weight (CMO:0000071)1111949780210707719Rat
1354610Bw34Body weight QTL 344.1body mass (VT:0001259)body weight (CMO:0000012)1160573753266453731Rat
738028Anxrr12Anxiety related response QTL 124.90.00001locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)1140048073185048073Rat
1354620Kidm19Kidney mass QTL 194kidney mass (VT:0002707)calculated kidney weight (CMO:0000160)1160573753210707719Rat
1576310Schws2Schwannoma susceptibility QTL 20.029nervous system integrity trait (VT:0010566)percentage of study population developing trigeminal nerve neurilemmomas during a period of time (CMO:0002017)1153788989198788989Rat
1354618Kidm15Kidney mass QTL 155kidney mass (VT:0002707)left kidney wet weight (CMO:0000083)1165707719210707719Rat
6903303Scl34Serum cholesterol QTL 342.50.0033blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)1173363824227535316Rat
631544Bp84Blood pressure QTL 845.6arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1132760429191190115Rat
152025212Bw190Body weight QTL 1905.7body mass (VT:0001259)1132966869206393015Rat
631548Bp88Blood pressure QTL 8850.001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)1140915717185915717Rat
1358189Cstrr1Cold stress response QTL 10.0001catecholamine amount (VT:0010543)urine norepinephrine level (CMO:0001629)1132760429191848948Rat
1354606Bp246Blood pressure QTL 2463.6arterial blood pressure trait (VT:2000000)pulse pressure (CMO:0000292)1111949780228180370Rat
7411599Foco11Food consumption QTL 1118.50.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)1153788989198788989Rat
1354602Bw35Body weight QTL 3512.2body mass (VT:0001259)body weight (CMO:0000012)1160573753210707719Rat


Genetic Models
This gene Umod is modified in the following models/strains:
SS-Umodem1Mcwi    


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
7 9 14 36 42 39 22 16 22 4 119 39 24 43 38 17 2 2

Sequence


Ensembl Acc Id: ENSRNOT00000021027   ⟹   ENSRNOP00000021027
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1183,247,936 - 183,261,030 (-)Ensembl
mRatBN7.2 Ensembl1173,816,601 - 173,829,695 (-)Ensembl
Rnor_6.0 Ensembl1189,186,026 - 189,199,376 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000096977   ⟹   ENSRNOP00000082923
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1183,247,674 - 183,261,024 (-)Ensembl
mRatBN7.2 Ensembl1173,816,339 - 173,830,302 (-)Ensembl
RefSeq Acc Id: NM_017082   ⟹   NP_058778
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81183,247,676 - 183,261,016 (-)NCBI
mRatBN7.21173,816,341 - 173,829,681 (-)NCBI
Rnor_6.01189,186,028 - 189,199,368 (-)NCBI
Rnor_5.01196,127,939 - 196,141,822 (-)NCBI
RGSC_v3.41177,729,212 - 177,742,552 (-)RGD
Celera1171,569,071 - 171,582,409 (-)RGD
Sequence:
RefSeq Acc Id: XM_063281291   ⟹   XP_063137361
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81183,247,678 - 183,261,665 (-)NCBI
RefSeq Acc Id: NP_058778   ⟸   NM_017082
- Peptide Label: precursor
- UniProtKB: Q642D6 (UniProtKB/Swiss-Prot),   P27590 (UniProtKB/Swiss-Prot)
- Sequence:
Ensembl Acc Id: ENSRNOP00000021027   ⟸   ENSRNOT00000021027
Ensembl Acc Id: ENSRNOP00000082923   ⟸   ENSRNOT00000096977
RefSeq Acc Id: XP_063137361   ⟸   XM_063281291
- Peptide Label: isoform X1
- UniProtKB: Q642D6 (UniProtKB/Swiss-Prot),   P27590 (UniProtKB/Swiss-Prot)
Protein Domains
EGF-like   ZP

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P27590-F1-model_v2 AlphaFold P27590 1-644 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:3940 AgrOrtholog
BioCyc Gene G2FUF-57654 BioCyc
Ensembl Genes ENSRNOG00000015557 Ensembl, ENTREZGENE
Ensembl Transcript ENSRNOT00000096977 ENTREZGENE
Gene3D-CATH 2.60.40.4100 UniProtKB/Swiss-Prot
  Laminin UniProtKB/Swiss-Prot
  Zona pellucida, ZP-N domain UniProtKB/Swiss-Prot
IMAGE_CLONE IMAGE:7109450 IMAGE-MGC_LOAD
InterPro EGF-like_Ca-bd_dom UniProtKB/Swiss-Prot
  EGF-like_dom UniProtKB/Swiss-Prot
  EGF-type_Asp/Asn_hydroxyl_site UniProtKB/Swiss-Prot
  EGF_Ca-bd_CS UniProtKB/Swiss-Prot
  EGF_dom UniProtKB/Swiss-Prot
  Growth_fac_rcpt_cys_sf UniProtKB/Swiss-Prot
  NOTCH1_EGF-like UniProtKB/Swiss-Prot
  ZP-C UniProtKB/Swiss-Prot
  ZP-C UniProtKB/Swiss-Prot
  ZP_chr UniProtKB/Swiss-Prot
  ZP_dom UniProtKB/Swiss-Prot
  ZP_dom_CS UniProtKB/Swiss-Prot
KEGG Report rno:25128 UniProtKB/Swiss-Prot
MGC_CLONE MGC:93496 IMAGE-MGC_LOAD
NCBI Gene 25128 ENTREZGENE
PANTHER ENDOGLIN/TGF-BETA RECEPTOR TYPE III UniProtKB/Swiss-Prot
  UROMODULIN UniProtKB/Swiss-Prot
Pfam D8C_UMOD UniProtKB/Swiss-Prot
  EGF_3 UniProtKB/Swiss-Prot
  EGF_CA UniProtKB/Swiss-Prot
  Zona_pellucida UniProtKB/Swiss-Prot
PhenoGen Umod PhenoGen
PRINTS ZPELLUCIDA UniProtKB/Swiss-Prot
PROSITE ASX_HYDROXYL UniProtKB/Swiss-Prot
  EGF_2 UniProtKB/Swiss-Prot
  EGF_3 UniProtKB/Swiss-Prot
  EGF_CA UniProtKB/Swiss-Prot
  ZP_1 UniProtKB/Swiss-Prot
  ZP_2 UniProtKB/Swiss-Prot
RatGTEx ENSRNOG00000015557 RatGTEx
SMART EGF UniProtKB/Swiss-Prot
  EGF_CA UniProtKB/Swiss-Prot
  SM00241 UniProtKB/Swiss-Prot
Superfamily-SCOP SSF57184 UniProtKB/Swiss-Prot
UniProt A0A0G2JSP1_RAT UniProtKB/TrEMBL
  A0A8I6GA39_RAT UniProtKB/TrEMBL
  A6I8K8_RAT UniProtKB/TrEMBL
  A6I8K9_RAT UniProtKB/TrEMBL
  A6I8L0_RAT UniProtKB/TrEMBL
  A6I8L1_RAT UniProtKB/TrEMBL
  A6I8L2_RAT UniProtKB/TrEMBL
  P27590 ENTREZGENE
  Q642D6 ENTREZGENE
  UROM_RAT UniProtKB/Swiss-Prot
UniProt Secondary Q642D6 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2003-04-09 Umod  uromodulin    Urmodulin (Tamm-Horsfall protein)  Name updated 629478 APPROVED
2002-06-10 Umod  Urmodulin (Tamm-Horsfall protein)      Symbol and Name status set to approved 70586 APPROVED

RGD Curation Notes
Note Type Note Reference
gene_product member of the GP-2/THP family of glycosylphosphatidylinositol (GPI)-linked glycoproteins 730085