Ucp3 (uncoupling protein 3) - Rat Genome Database

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Gene: Ucp3 (uncoupling protein 3) Rattus norvegicus
Symbol: Ucp3
Name: uncoupling protein 3
RGD ID: 3933
Description: Predicted to enable oxidative phosphorylation uncoupler activity and proton transmembrane transporter activity. Involved in several processes, including response to fenofibrate; response to insulin; and response to superoxide. Predicted to be located in mitochondrial inner membrane. Used to study type 2 diabetes mellitus. Biomarker of congestive heart failure; hypertension; hyperthyroidism; hypothyroidism; and prediabetes syndrome. Human ortholog(s) of this gene implicated in coronary restenosis; diabetic neuropathy; glucose metabolism disease (multiple); and obesity. Orthologous to human UCP3 (uncoupling protein 3); INTERACTS WITH (+)-catechin; 6-propyl-2-thiouracil; ammonium chloride.
Type: protein-coding
Previously known as: mitochondrial uncoupling protein 3; putative mitochondrial transporter UCP3; solute carrier family 25 member 9; UCP 3; uncoupling protein 3 (mitochondrial, proton carrier); Uncoupling protein 3 mitochondrial; Uncoupling protein 3, mitochondrial
RGD Orthologs
Green Monkey
Alliance Orthologs
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Rat AssemblyChrPosition (strand)SourceGenome Browsers
GRCr81164,227,910 - 164,240,893 (+)NCBIGRCr8
mRatBN7.21154,815,777 - 154,828,764 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1154,815,777 - 154,828,762 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1162,810,789 - 162,823,741 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01169,990,890 - 170,003,842 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01162,864,787 - 162,877,739 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01165,482,912 - 165,495,895 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1165,482,155 - 165,496,206 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01171,683,566 - 171,697,139 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41157,896,001 - 157,909,608 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11157,974,793 - 157,988,399 (+)NCBI
Celera1152,898,320 - 152,911,676 (+)NCBICelera
RH 3.4 Map11258.1RGD
Cytogenetic Map1q32NCBI
JBrowse: View Region in Genome Browser (JBrowse)

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-catechin  (EXP)
(+)-dexrazoxane  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (ISO)
3'-amino-3'-deoxy-N(6),N(6)-dimethyladenosine  (ISO)
3,5-diethoxycarbonyl-1,4-dihydrocollidine  (ISO)
4,4'-sulfonyldiphenol  (ISO)
4-hydroxyphenyl retinamide  (ISO)
5-methyl-4-oxido-2-pyrazin-4-iumcarboxylic acid  (ISO)
6-propyl-2-thiouracil  (EXP)
acrylamide  (ISO)
albuterol  (ISO)
aldehydo-D-glucose  (ISO)
ammonium chloride  (EXP)
amphetamine  (EXP)
aristolochic acid A  (ISO)
beauvericin  (ISO)
bezafibrate  (EXP,ISO)
bis(2-ethylhexyl) phthalate  (ISO)
bisphenol A  (EXP,ISO)
bisphenol F  (ISO)
capsaicin  (EXP)
capsiate  (EXP)
carbon nanotube  (ISO)
CGP 52608  (ISO)
chlorpyrifos  (ISO)
ciglitazone  (ISO)
cisplatin  (ISO)
clofibrate  (ISO)
cordycepin  (ISO)
Cuprizon  (EXP)
D-glucose  (ISO)
dehydroepiandrosterone  (EXP)
dexamethasone  (EXP)
Dibutyl phosphate  (ISO)
Diosbulbin B  (ISO)
dioxygen  (ISO)
doxorubicin  (EXP,ISO)
enniatin  (ISO)
fenofibrate  (EXP)
flavonoids  (EXP)
folic acid  (ISO)
fructose  (EXP)
glucose  (ISO)
GW 7647  (ISO)
isoprenaline  (EXP,ISO)
kaempferol  (ISO)
Licochalcone B  (ISO)
lipopolysaccharide  (EXP)
losartan  (EXP)
lutein  (ISO)
methimazole  (EXP)
myo-inositol hexakisphosphate  (ISO)
nevirapine  (EXP)
ochratoxin A  (ISO)
oleic acid  (EXP,ISO)
ozone  (ISO)
pentachlorophenol  (ISO)
perfluorooctane-1-sulfonic acid  (EXP,ISO)
perfluorooctanoic acid  (ISO)
phenformin  (EXP)
picolinic acid  (EXP)
picrotoxin  (EXP)
pirinixic acid  (EXP,ISO)
potassium dichromate  (ISO)
propanal  (ISO)
quercetin  (ISO)
reactive oxygen species  (ISO)
resveratrol  (EXP,ISO)
rotenone  (EXP)
SB 203580  (ISO)
stavudine  (ISO)
streptozocin  (ISO)
T-2 toxin  (EXP)
telmisartan  (ISO)
testosterone  (ISO)
titanium dioxide  (ISO)
topiramate  (EXP)
triacsin C  (ISO)
trichloroethene  (EXP,ISO)
troglitazone  (EXP,ISO)
valproic acid  (ISO)
venlafaxine hydrochloride  (EXP)
vinclozolin  (EXP)
zinc atom  (EXP,ISO)
zinc sulfate  (EXP)
zinc(0)  (EXP,ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function


References - curated
# Reference Title Reference Citation
1. Effects of mutations in the human uncoupling protein 3 gene on the respiratory quotient and fat oxidation in severe obesity and type 2 diabetes. Argyropoulos G, etal., J Clin Invest. 1998 Oct 1;102(7):1345-51.
2. The genetic association database. Becker KG, etal., Nat Genet. 2004 May;36(5):431-2.
3. Endurance training attenuates the bioenergetics alterations of rat skeletal muscle mitochondria submitted to acute hypoxia: Role of ROS and UCP3. Bo H, etal., Sheng Li Xue Bao. 2008 Dec 25;60(6):767-776.
4. Uncoupling protein-3: a new member of the mitochondrial carrier family with tissue-specific expression. Boss O, etal., FEBS Lett 1997 May 12;408(1):39-42.
5. Uncoupling protein downregulation in doxorubicin-induced heart failure improves mitochondrial coupling but increases reactive oxygen species generation. Bugger H, etal., Cancer Chemother Pharmacol. 2011 Jun;67(6):1381-8. doi: 10.1007/s00280-010-1441-7. Epub 2010 Aug 31.
6. Type 1 diabetic akita mouse hearts are insulin sensitive but manifest structurally abnormal mitochondria that remain coupled despite increased uncoupling protein 3. Bugger H, etal., Diabetes. 2008 Nov;57(11):2924-32. Epub 2008 Aug 4.
7. Overexpression of the mitochondrial T3 receptor induces skeletal muscle atrophy during aging. Casas F, etal., PLoS One. 2009 May 20;4(5):e5631. doi: 10.1371/journal.pone.0005631.
8. Overexpression of uncoupling protein 3 in skeletal muscle protects against fat-induced insulin resistance. Choi CS, etal., J Clin Invest. 2007 Jul;117(7):1995-2003.
9. Concordant mRNA expression of UCP-3, but not UCP-2, with mitochondrial thioesterase-1 in brown adipose tissue and skeletal muscle in db/db diabetic mice. Clapham JC, etal., Biochem Biophys Res Commun. 2001 Oct 12;287(5):1058-62.
10. Mice overexpressing human uncoupling protein-3 in skeletal muscle are hyperphagic and lean. Clapham JC, etal., Nature 2000 Jul 27;406(6794):415-8.
11. The uncoupling protein 3 -55 C -->T variant is not associated with Type II diabetes mellitus in Danish subjects. Dalgaard LT, etal., Diabetologia. 2001 Aug;44(8):1065-7.
12. Differential 3,5,3'-triiodothyronine-mediated regulation of uncoupling protein 3 transcription: role of Fatty acids. de Lange P, etal., Endocrinology. 2007 Aug;148(8):4064-72. Epub 2007 May 3.
13. A long-term high-fat diet increases oxidative stress, mitochondrial damage and apoptosis in the inner ear of D-galactose-induced aging rats. Du Z, etal., Hear Res. 2012 May;287(1-2):15-24. doi: 10.1016/j.heares.2012.04.012. Epub 2012 Apr 21.
14. Superoxide activates mitochondrial uncoupling proteins. Echtay KS, etal., Nature 2002 Jan 3;415(6867):96-9.
15. Altered gene expression of uncoupling protein-2 and -3 in stroke-prone spontaneously hypertensive rats. Fukunaga Y, etal., J Hypertens. 2000 Sep;18(9):1233-8.
16. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
17. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
18. Sterol regulatory element binding protein-1c expression and action in rat muscles: insulin-like effects on the control of glycolytic and lipogenic enzymes and UCP3 gene expression. Guillet-Deniau I, etal., Diabetes 2002 Jun;51(6):1722-8.
19. Energy metabolism and expression of uncoupling proteins 1, 2, and 3 after 21 days of recovery from intracerebroventricular mouse leptin in rats. Gullicksen PS, etal., Physiol Behav 2002 Apr 1;75(4):473-82.
20. Linkage exclusion analysis of two candidate regions on chromosomes 7 and 11: leptin and UCP2/UCP3 are not QTLs for obesity in US Caucasians. Guo JJ, etal., Biochem Biophys Res Commun. 2005 Jul 1;332(2):602-8.
21. The common -55 C/T polymorphism in the promoter region of the uncoupling protein 3 gene reduces prevalence of obesity and elevates serum high-density lipoprotein cholesterol levels in the general Japanese population. Hamada T, etal., Metabolism. 2008 Mar;57(3):410-5.
22. Decreased mitochondrial proton leak and reduced expression of uncoupling protein 3 in skeletal muscle of obese diet-resistant women. Harper ME, etal., Diabetes. 2002 Aug;51(8):2459-66.
23. Effects of streptozotocin-induced diabetes and insulin treatment on the hypothalamic melanocortin system and muscle uncoupling protein 3 expression in rats. Havel PJ, etal., Diabetes. 2000 Feb;49(2):244-52.
24. [UCP2 and UCP3 gene expression, heart function and oxygen cost of myocardial work changes during aging and ischemia-reperfusion] Hoshovs'ka IuV, etal., Fiziol Zh. 2009;55(3):26-36.
25. Genetic variants in the UCP2-UCP3 gene cluster and risk of diabetes in the Women's Health Initiative Observational Study. Hsu YH, etal., Diabetes. 2008 Apr;57(4):1101-7. Epub 2008 Jan 25.
26. Opposite regulation of uncoupling protein 1 and uncoupling protein 3 in vivo in brown adipose tissue of cold-exposed rats. Jakus PB, etal., FEBS Lett 2002 May 22;519(1-3):210-4.
27. Upregulation of uncoupling protein-3 in skeletal muscle during exercise: a potential antioxidant function. Jiang N, etal., Free Radic Biol Med. 2009 Jan 15;46(2):138-45. Epub 2008 Oct 9.
28. Exercise induces an increase in muscle UCP3 as a component of the increase in mitochondrial biogenesis. Jones TE, etal., Am J Physiol Endocrinol Metab 2003 Jan;284(1):E96-101.
29. Localization of the mitochondrial uncoupling protein family in the rat inner ear. Kitahara T, etal., Hear Res. 2004 Oct;196(1-2):39-48.
30. High-density rat radiation hybrid maps containing over 24,000 SSLPs, genes, and ESTs provide a direct link to the rat genome sequence. Kwitek AE, etal., Genome Res. 2004 Apr;14(4):750-7
31. Regulation of the third member of the uncoupling protein family, UCP3, by cold and thyroid hormone. Larkin S, etal., Biochem Biophys Res Commun. 1997 Nov 7;240(1):222-7.
32. Cloning of rat uncoupling protein-3 and uncoupling protein-2 cDNAs: their gene expression in rats fed high-fat diet. Matsuda J, etal., FEBS Lett 1997 Nov 24;418(1-2):200-4.
33. An uncoupling protein 3 gene polymorphism associated with a lower risk of developing Type II diabetes and with atherogenic lipid profile in a French cohort. Meirhaeghe A, etal., Diabetologia. 2000 Nov;43(11):1424-8.
34. Skeletal muscle uncoupling protein-3 restores upon intervention in the prediabetic and diabetic state: implications for diabetes pathogenesis? Mensink M, etal., Diabetes Obes Metab. 2007 Jul;9(4):594-6.
35. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
36. UCP3 in muscle wasting, a role in modulating lipotoxicity? Minnaard R, etal., FEBS Lett. 2006 Oct 2;580(22):5172-6. Epub 2006 Sep 5.
37. Bezafibrate-induced changes over time in the expression of uncoupling protein (UCP) mRNA in the tissues: a study in spontaneously type 2 diabetic rats with visceral obesity. Mori Y, etal., J Atheroscler Thromb. 2004;11(4):224-31.
38. Increased mitochondrial uncoupling proteins, respiratory uncoupling and decreased efficiency in the chronically infarcted rat heart. Murray AJ, etal., J Mol Cell Cardiol. 2008 Apr;44(4):694-700. Epub 2008 Feb 9.
39. Amelioration of high fructose-induced metabolic derangements by activation of PPARalpha. Nagai Y, etal., Am J Physiol Endocrinol Metab 2002 May;282(5):E1180-90.
40. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
41. Association between obesity and insulin resistance with UCP2-UCP3 gene variants in Spanish children and adolescents. Ochoa MC, etal., Mol Genet Metab. 2007 Dec;92(4):351-8. Epub 2007 Sep 17.
42. Identification of a polymorphism of UCP3 associated with recurrent in-stent restenosis of coronary arteries. Oguri M, etal., Int J Mol Med. 2007 Oct;20(4):533-8.
43. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
44. GOA pipeline RGD automated data pipeline
45. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
46. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
47. Functional polymorphisms of UCP2 and UCP3 are associated with a reduced prevalence of diabetic neuropathy in patients with type 1 diabetes. Rudofsky G Jr, etal., Diabetes Care. 2006 Jan;29(1):89-94.
48. DHEA administration increases brown fat uncoupling protein 1 levels in obese OLETF rats. Ryu JW, etal., Biochem Biophys Res Commun. 2003 Apr 4;303(2):726-31.
49. Uncoupling protein 3 content is decreased in skeletal muscle of patients with type 2 diabetes. Schrauwen P, etal., Diabetes. 2001 Dec;50(12):2870-3.
50. Reduction of diet-induced obesity in transgenic mice overexpressing uncoupling protein 3 in skeletal muscle. Son C, etal., Diabetologia. 2004 Jan;47(1):47-54. Epub 2003 Dec 12.
51. Roles of norepinephrine, free Fatty acids, thyroid status, and skeletal muscle uncoupling protein 3 expression in sympathomimetic-induced thermogenesis. Sprague JE, etal., J Pharmacol Exp Ther. 2007 Jan;320(1):274-80. Epub 2006 Sep 29.
52. Evidence for mitochondrial thioesterase 1 as a peroxisome proliferator-activated receptor-alpha-regulated gene in cardiac and skeletal muscle. Stavinoha MA, etal., Am J Physiol Endocrinol Metab. 2004 Nov;287(5):E888-95. Epub 2004 Aug 3.
53. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, etal., Proc Natl Acad Sci U S A. 2002 Dec 24;99(26):16899-903. Epub 2002 Dec 11.
54. [Expression of UCP3 and the sensitivity of mitochondrial permeability transition pore opening to Ca2+ in old rat heart under activation of biosynthesis of coenzyme Q] Strutyns'ka NA, etal., Fiziol Zh. 2009;55(3):44-54.
55. Tentative Sequence Identification Numbers Tentative Sequence Data IDs. TIGR Gene Index, Rat Data
56. Changes in FAT/CD36, UCP2, UCP3 and GLUT4 gene expression during lipid infusion in rat skeletal and heart muscle. Vettor R, etal., Int J Obes Relat Metab Disord 2002 Jun;26(6):838-47.
57. Association between uncoupling protein polymorphisms (UCP2-UCP3) and energy metabolism/obesity in Pima indians. Walder K, etal., Hum Mol Genet. 1998 Sep;7(9):1431-5.
58. Enhanced diabetogenic effect of streptozotocin in mice overexpressing UCP-3 in skeletal muscle. Wang S, etal., Ann N Y Acad Sci. 2002 Jun;967:112-9.
59. Developmental programming of adult hyperinsulinemia, increased proinflammatory cytokine production, and altered skeletal muscle expression of SLC2A4 (GLUT4) and uncoupling protein 3. Wyrwoll CS, etal., J Endocrinol. 2008 Sep;198(3):571-9. Epub 2008 Jun 30.
60. Genomic modulation of mitochondrial respiratory genes in the hypertrophied heart reflects adaptive changes in mitochondrial and contractile function. Zungu M, etal., Am J Physiol Heart Circ Physiol. 2007 Nov;293(5):H2819-25. Epub 2007 Aug 17.
Additional References at PubMed
PMID:9506477   PMID:9725803   PMID:10748195   PMID:10748196   PMID:11707458   PMID:12222743   PMID:12397391   PMID:12466947   PMID:12603007   PMID:12676547   PMID:12692085   PMID:12706490  
PMID:12721157   PMID:12750152   PMID:12782304   PMID:12813156   PMID:12912909   PMID:14605003   PMID:14651853   PMID:14733944   PMID:15064282   PMID:15262223   PMID:15308491   PMID:15346231  
PMID:15349725   PMID:15489334   PMID:15757654   PMID:15886224   PMID:16079144   PMID:16084485   PMID:16329595   PMID:16387447   PMID:16434555   PMID:16595124   PMID:17761668   PMID:17878603  
PMID:17884810   PMID:18239634   PMID:18614015   PMID:18685530   PMID:19227473   PMID:19954423   PMID:20428795   PMID:21084676   PMID:21524945   PMID:23084644   PMID:24950599   PMID:25944715  


Comparative Map Data
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
GRCr81164,227,910 - 164,240,893 (+)NCBIGRCr8
mRatBN7.21154,815,777 - 154,828,764 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1154,815,777 - 154,828,762 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1162,810,789 - 162,823,741 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01169,990,890 - 170,003,842 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01162,864,787 - 162,877,739 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01165,482,912 - 165,495,895 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1165,482,155 - 165,496,206 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01171,683,566 - 171,697,139 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41157,896,001 - 157,909,608 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11157,974,793 - 157,988,399 (+)NCBI
Celera1152,898,320 - 152,911,676 (+)NCBICelera
RH 3.4 Map11258.1RGD
Cytogenetic Map1q32NCBI
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
GRCh381174,000,277 - 74,009,085 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1174,000,277 - 74,009,085 (-)EnsemblGRCh38hg38GRCh38
GRCh371173,711,322 - 73,720,130 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361173,388,985 - 73,397,778 (-)NCBINCBI36Build 36hg18NCBI36
Build 341173,392,374 - 73,397,778NCBI
Celera1171,018,129 - 71,027,086 (-)NCBICelera
Cytogenetic Map11q13.4NCBI
HuRef1170,007,226 - 70,016,183 (-)NCBIHuRef
CHM1_11173,595,177 - 73,604,136 (-)NCBICHM1_1
T2T-CHM13v2.01173,929,606 - 73,938,415 (-)NCBIT2T-CHM13v2.0
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
GRCm397100,122,198 - 100,135,639 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl7100,122,197 - 100,135,639 (+)EnsemblGRCm39 Ensembl
GRCm387100,472,991 - 100,486,432 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl7100,472,990 - 100,486,432 (+)EnsemblGRCm38mm10GRCm38
MGSCv377107,621,500 - 107,634,941 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv367100,347,073 - 100,360,514 (+)NCBIMGSCv36mm8
Celera7100,810,580 - 100,824,026 (+)NCBICelera
Cytogenetic Map7E2NCBI
cM Map754.36NCBI
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
ChiLan1.0 EnsemblNW_00495541417,558,889 - 17,578,737 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495541417,558,889 - 17,578,108 (+)NCBIChiLan1.0ChiLan1.0
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
NHGRI_mPanPan1-v2974,941,880 - 74,953,797 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11175,986,899 - 75,998,075 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01169,072,143 - 69,085,424 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11172,380,180 - 72,389,274 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1172,380,180 - 72,389,274 (-)Ensemblpanpan1.1panPan2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
CanFam3.12124,272,522 - 24,290,304 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2124,277,896 - 24,288,639 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha2124,049,763 - 24,055,700 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.02124,484,075 - 24,496,484 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl2124,484,070 - 24,496,484 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.12124,284,466 - 24,290,404 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02124,484,328 - 24,490,265 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02124,399,875 - 24,405,814 (+)NCBIUU_Cfam_GSD_1.0
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
HiC_Itri_2NW_02440494761,482,972 - 61,496,412 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049364983,082,575 - 3,095,737 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049364983,082,575 - 3,095,739 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
Sscrofa11.1 Ensembl98,378,021 - 8,386,211 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.198,378,023 - 8,389,452 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.299,167,483 - 9,178,955 (-)NCBISscrofa10.2Sscrofa10.2susScr3
Pig Cytomap9p21-p24NCBI
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
ChlSab1.1165,269,611 - 65,279,079 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl165,269,607 - 65,278,807 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366604360,587,459 - 60,596,911 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0


Variants in Ucp3
57 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:166
Count of miRNA genes:131
Interacting mature miRNAs:146
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.

QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
70225Bp58Blood pressure QTL 583.3arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)132356093162846471Rat
10059597Bp377Blood pressure QTL 3773.420.025arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)132737458199368955Rat
1578654Bss10Bone structure and strength QTL 104femur morphology trait (VT:0000559)femoral neck cortical cross-sectional area (CMO:0001702)149393172159356837Rat
634314Niddm44Non-insulin dependent diabetes mellitus QTL 44blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)149393289199050459Rat
1578780Cm52Cardiac mass QTL 523.30.0001heart mass (VT:0007028)heart wet weight (CMO:0000069)181591954219808434Rat
724521Uae1Urinary albumin excretion QTL 13.80.0001urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)190508614173018436Rat
1358902Bw47Body weight QTL 471.67body mass (VT:0001259)body weight (CMO:0000012)190508614180359386Rat
1331793Bp200Blood pressure QTL 2003.71601arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)194494440172949803Rat
1331751Bp199Blood pressure QTL 1993.60022arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)194494440181830018Rat
1331749Hrtrt11Heart rate QTL 112.973heart pumping trait (VT:2000009)heart rate (CMO:0000002)194494440198211706Rat
70209Niddm23Non-insulin dependent diabetes mellitus QTL 232.82blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)194494440198324465Rat
731168Bp154Blood pressure QTL 1543.4arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)194642644214537671Rat
8655649Arrd1Age-related retinal degeneration QTL 14.89retinal layer morphology trait (VT:0003727)percentage of study population developing retinopathy during a period of time (CMO:0002453)1100357752183970443Rat
1354591Cm36Cardiac mass QTL 364.1heart left ventricle mass (VT:0007031)calculated heart weight (CMO:0000073)1102813953201278233Rat
1354615Cm32Cardiac mass QTL 325.2heart left ventricle mass (VT:0007031)heart left ventricle wet weight (CMO:0000071)1102813953201278233Rat
1354606Bp246Blood pressure QTL 2463.6arterial blood pressure trait (VT:2000000)pulse pressure (CMO:0000292)1102813953218753816Rat
1300158Bp173Blood pressure QTL 1733.48arterial blood pressure trait (VT:2000000)blood pressure time series experimental set point of the baroreceptor response (CMO:0002593)1115540693185145286Rat
7794788Mcs32Mammary carcinoma susceptibility QTL 322.61mammary gland integrity trait (VT:0010552)mammary tumor incidence/prevalence measurement (CMO:0000946)1115540693238914717Rat
631199Cm23Cardiac mass QTL 234.60.0004heart left ventricle mass (VT:0007031)heart left ventricle wet weight (CMO:0000071)1115585465172949803Rat
7421630Bp362Blood pressure QTL 3620.001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)1118608292241799120Rat
2313060Bss71Bone structure and strength QTL 712.60.0001long bone metaphysis morphology trait (VT:0000133)tibia midshaft total cross-sectional area (CMO:0001715)1118944747163944747Rat
631205Bp196Blood pressure QTL 19640.0001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)1118944897199050459Rat
1598850Bp297Blood pressure QTL 2972.1arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1121006655166006655Rat
1598866Bp287Blood pressure QTL 2875.1arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1121006655166006655Rat
61442Strs1Sensitivity to stroke QTL 17.4cerebrum integrity trait (VT:0010549)post-insult time to onset of cerebrovascular lesion (CMO:0002343)1121767634166767634Rat
2293140Bp313Blood pressure QTL 313arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1121833674166833674Rat
631544Bp84Blood pressure QTL 845.6arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1123350408181759564Rat
1358189Cstrr1Cold stress response QTL 10.0001catecholamine amount (VT:0010543)urine norepinephrine level (CMO:0001629)1123350408182418476Rat
1641895Bp298Blood pressure QTL 298arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)1123350408182418476Rat
1578770Stresp23Stress response QTL 23kidney sympathetic nerve activity (VT:0004050)stimulated renal sympathetic nerve activity to basal renal sympathetic nerve activity ratio (CMO:0001786)1123350408182418476Rat
631549Bp89Blood pressure QTL 895.7arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1123350581201284552Rat
634348Bp138Blood pressure QTL 138arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1125611501168883176Rat
9685799Bp375Blood pressure QTL 375arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1125611501170611501Rat
631654Bp107Blood pressure QTL 107arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1125611501170611501Rat
9685802Bp376Blood pressure QTL 376arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1126540680171540680Rat
738006Anxrr14Anxiety related response QTL 1440.00035locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)1130636910175636910Rat
738028Anxrr12Anxiety related response QTL 124.90.00001locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)1130636910175636910Rat
631202Gluco13Glucose level QTL 130.0001blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)1131763437159756369Rat
6893347Bw98Body weight QTL 980.20.53body mass (VT:0001259)body weight (CMO:0000012)1133680936178680936Rat
6893361Bw104Body weight QTL 1040.590.27body mass (VT:0001259)body weight (CMO:0000012)1133680936178680936Rat
1558645Bw55Body weight QTL 553.20.004body mass (VT:0001259)body weight (CMO:0000012)1133680936178680936Rat
631206Niddm40Non-insulin dependent diabetes mellitus QTL 40blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)1136745990163747690Rat
71118Thym1Thymus enlargement QTL 110.170.001thymus mass (VT:0004954)thymus weight to body weight ratio (CMO:0000612)1136829932181829932Rat
724550Thym3Thymus enlargement QTL 37.820.001thymus mass (VT:0004954)thymus weight to body weight ratio (CMO:0000612)1136829932181829932Rat
631519Pia11Pristane induced arthritis QTL 115.3joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1136830018181830018Rat
1598853Memor3Memory QTL 34.5exploratory behavior trait (VT:0010471)total horizontal distance resulting from voluntary locomotion in an experimental apparatus (CMO:0001443)1143506580212458660Rat
61348Bp30Blood pressure QTL 302.4arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1144017057197814409Rat
70160Bw18Body weight QTL 185.7body mass (VT:0001259)body weight (CMO:0000012)1144267353196383668Rat
737828Hcas3Hepatocarcinoma susceptibility QTL 34.9liver integrity trait (VT:0010547)liver tumorous lesion volume to total liver volume ratio (CMO:0001082)1144267353222987745Rat
2302378Insul11Insulin level QTL 113.25blood insulin amount (VT:0001560)serum insulin level (CMO:0000358)1144267353251128347Rat
634315Niddm45Non-insulin dependent diabetes mellitus QTL 457.16blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)1144267916172949660Rat
61379Bp44Blood pressure QTL 4419.2arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1144267916174133260Rat
7771612Cm80Cardiac mass QTL 808.4heart left ventricle mass (VT:0007031)heart left ventricle weight (CMO:0000776)1149448574221264292Rat
724531Uae5Urinary albumin excretion QTL 54urine albumin amount (VT:0002871)urine albumin level (CMO:0000130)1150700142252085212Rat
1578759Uae30Urinary albumin excretion QTL 303.30.003urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)1150700247252085048Rat
1578778Pur4Proteinuria QTL 43.30.003urine total protein amount (VT:0000032)urine total protein excretion rate (CMO:0000756)1150700247252085048Rat
1354602Bw35Body weight QTL 3512.2body mass (VT:0001259)body weight (CMO:0000012)1151162512201278233Rat
1354620Kidm19Kidney mass QTL 194kidney mass (VT:0002707)calculated kidney weight (CMO:0000160)1151162512201278233Rat
1354634Kidm12Kidney mass QTL 123.9kidney mass (VT:0002707)right kidney wet weight (CMO:0000082)1151162512201278233Rat
1354636Lmblg1Limb length QTL 16.4tibia length (VT:0004357)tibia length (CMO:0000450)1151162512201278233Rat
1354610Bw34Body weight QTL 344.1body mass (VT:0001259)body weight (CMO:0000012)1151162512256448636Rat
1354646Kidm18Kidney mass QTL 185.7kidney mass (VT:0002707)calculated kidney weight (CMO:0000160)1151162512256448636Rat
1354661Bw33Body weight QTL 335.2body mass (VT:0001259)body weight (CMO:0000012)1151162512256448636Rat
1358886Bp260Blood pressure QTL 2603.67arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)1151162766225824951Rat
61343Bp28Blood pressure QTL 28arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1151646613196646613Rat
1549837Hcar15Hepatocarcinoma resistance QTL 150.05liver integrity trait (VT:0010547)liver tumorous lesion number (CMO:0001068)1153136852260522016Rat
2303622Vencon6Ventilatory control QTL 60.001respiration trait (VT:0001943)respiration rate (CMO:0000289)1154561505199561505Rat

Markers in Region
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21154,820,746 - 154,820,912 (+)MAPPERmRatBN7.2
Rnor_6.01165,487,882 - 165,488,045NCBIRnor6.0
Rnor_5.01171,688,536 - 171,688,699UniSTSRnor5.0
RGSC_v3.41157,900,971 - 157,901,134UniSTSRGSC3.4
Celera1152,903,290 - 152,903,448UniSTS
Cytogenetic Map1q32UniSTS
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21154,820,760 - 154,820,908 (+)MAPPERmRatBN7.2
Rnor_6.01165,487,896 - 165,488,041NCBIRnor6.0
Rnor_5.01171,688,550 - 171,688,695UniSTSRnor5.0
RGSC_v3.41157,900,984 - 157,901,130RGDRGSC3.4
RGSC_v3.41157,900,985 - 157,901,130UniSTSRGSC3.4
RGSC_v3.11157,979,777 - 157,979,923RGD
Celera1152,903,304 - 152,903,444UniSTS
Cytogenetic Map1q32UniSTS
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21154,827,497 - 154,827,660 (+)MAPPERmRatBN7.2
Rnor_6.01165,494,629 - 165,494,791NCBIRnor6.0
Rnor_5.01171,695,873 - 171,696,035UniSTSRnor5.0
RGSC_v3.41157,908,342 - 157,908,504UniSTSRGSC3.4
Celera1152,910,410 - 152,910,572UniSTS
RH 3.4 Map11258.1UniSTS
Cytogenetic Map1q32UniSTS
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21154,828,499 - 154,828,647 (+)MAPPERmRatBN7.2
Rnor_6.01165,495,631 - 165,495,778NCBIRnor6.0
Rnor_5.01171,696,875 - 171,697,022UniSTSRnor5.0
RGSC_v3.41157,909,344 - 157,909,491UniSTSRGSC3.4
Celera1152,911,412 - 152,911,559UniSTS
RH 3.4 Map11260.3UniSTS
Cytogenetic Map1q32UniSTS
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21154,822,010 - 154,822,749 (+)MAPPERmRatBN7.2
Rnor_6.01165,489,142 - 165,489,880NCBIRnor6.0
Rnor_5.01171,689,796 - 171,690,534UniSTSRnor5.0
RGSC_v3.41157,902,231 - 157,902,969UniSTSRGSC3.4
Celera1152,904,545 - 152,905,283UniSTS
Cytogenetic Map1q32UniSTS
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21154,822,698 - 154,823,080 (+)MAPPERmRatBN7.2
Rnor_6.01165,489,830 - 165,490,211NCBIRnor6.0
Rnor_5.01171,690,484 - 171,690,865UniSTSRnor5.0
Celera1152,905,233 - 152,905,614UniSTS
Cytogenetic Map1q32UniSTS


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
Medium 3 2 8 11 8
Low 2 23 13 17 11 9 11
Below cutoff 1 4 11 11 11 22 8 22


RefSeq Acc Id: ENSRNOT00000024005   ⟹   ENSRNOP00000024005
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1154,815,777 - 154,828,762 (+)Ensembl
Rnor_6.0 Ensembl1165,482,155 - 165,496,206 (+)Ensembl
RefSeq Acc Id: NM_013167   ⟹   NP_037299
Rat AssemblyChrPosition (strand)Source
GRCr81164,227,910 - 164,240,893 (+)NCBI
mRatBN7.21154,815,777 - 154,828,764 (+)NCBI
Rnor_6.01165,482,912 - 165,495,895 (+)NCBI
Rnor_5.01171,683,566 - 171,697,139 (+)NCBI
RGSC_v3.41157,896,001 - 157,909,608 (+)RGD
Celera1152,898,320 - 152,911,676 (+)RGD
RefSeq Acc Id: NP_037299   ⟸   NM_013167
- UniProtKB: P56499 (UniProtKB/Swiss-Prot),   A6I6N5 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSRNOP00000024005   ⟸   ENSRNOT00000024005

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P56499-F1-model_v2 AlphaFold P56499 1-308 view protein structure


eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

RGD ID:13690243
Promoter ID:EPDNEW_R766
Type:initiation region
Description:uncoupling protein 3
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Rat AssemblyChrPosition (strand)Source
Rnor_6.01165,482,884 - 165,482,944EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:3933 AgrOrtholog
BioCyc Gene G2FUF-58335 BioCyc
Ensembl Genes ENSRNOG00000017716 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
  ENSRNOG00055027608 UniProtKB/Swiss-Prot
  ENSRNOG00060002901 UniProtKB/Swiss-Prot
  ENSRNOG00065024116 UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000024005 ENTREZGENE
  ENSRNOT00000024005.6 UniProtKB/Swiss-Prot
  ENSRNOT00055047832 UniProtKB/Swiss-Prot
  ENSRNOT00060004694 UniProtKB/Swiss-Prot
  ENSRNOT00065041367 UniProtKB/Swiss-Prot
Gene3D-CATH UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro Mit_carrier UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Mitochondrial_sb/sol_carrier UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Mt_carrier_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:25708 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam Mito_carr UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Ucp3 PhenoGen
RatGTEx ENSRNOG00000017716 RatGTEx
  ENSRNOG00055027608 RatGTEx
  ENSRNOG00060002901 RatGTEx
  ENSRNOG00065024116 RatGTEx
Superfamily-SCOP Mitochondrial carrier UniProtKB/TrEMBL, UniProtKB/Swiss-Prot
TIGR TC209775
  P56499 ENTREZGENE, UniProtKB/Swiss-Prot

Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2016-05-05 Ucp3  uncoupling protein 3  Ucp3  uncoupling protein 3 (mitochondrial, proton carrier)  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2006-03-30 Ucp3  uncoupling protein 3 (mitochondrial, proton carrier)    uncoupling protein 3  Name updated 1299863 APPROVED
2002-06-10 Ucp3  Uncoupling protein 3, mitochondrial      Symbol and Name status set to approved 70586 APPROVED

RGD Curation Notes
Note Type Note Reference
gene_expression mRNA highly expressed in the skeletal muscles after exercise, not detected in nonexercised muscle 628553
gene_process component of mitochondrial biogenesis involved in thermogenesis and energy expenditure 628553
gene_regulation exercise induces an increase in the skeletal muscle 628553
gene_regulation increased uncoupling activity and mitochondrial proton conductance is induced by superoxide 737664