Ucp2 (uncoupling protein 2) - Rat Genome Database

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Gene: Ucp2 (uncoupling protein 2) Rattus norvegicus
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Symbol: Ucp2
Name: uncoupling protein 2
RGD ID: 3932
Description: Predicted to enable several functions, including C4-dicarboxylate transmembrane transporter activity; GDP binding activity; and inorganic anion transmembrane transporter activity. Involved in several processes, including cellular response to lead ion; liver regeneration; and negative regulation of insulin secretion involved in cellular response to glucose stimulus. Predicted to be located in mitochondrial membrane. Used to study hypertension; metabolic dysfunction-associated steatotic liver disease; transient cerebral ischemia; and type 2 diabetes mellitus. Biomarker of congestive heart failure; hypothyroidism; obstructive jaundice; steatotic liver disease (multiple); and type 2 diabetes mellitus. Human ortholog(s) of this gene implicated in carotid artery disease; diabetic neuropathy; end stage renal disease; hypertension; and obesity. Orthologous to human UCP2 (uncoupling protein 2); PARTICIPATES IN forkhead class A signaling pathway; INTERACTS WITH (+)-catechin; (R)-lipoic acid; (R)-noradrenaline.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: dicarboxylate carrier SLC25A8; mitochondrial uncoupling protein 2; solute carrier family 25 member 8; UCP 2; uncoupling protein 2 (mitochondrial, proton carrier); Uncoupling protein 2 mitochondrial; Uncoupling protein 2, mitochondrial
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Allele / Splice: Ucp2em1Mcwi  
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81164,251,373 - 164,257,742 (+)NCBIGRCr8
mRatBN7.21154,839,242 - 154,845,612 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1154,839,209 - 154,845,611 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1162,834,282 - 162,840,647 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01170,014,387 - 170,020,752 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01162,888,256 - 162,894,621 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01165,506,375 - 165,512,744 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1165,506,361 - 165,512,744 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01171,707,625 - 171,713,991 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41157,925,514 - 157,928,222 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11158,000,971 - 158,007,311 (+)NCBI
Celera1152,922,529 - 152,928,898 (+)NCBICelera
RH 3.4 Map11261.4RGD
Cytogenetic Map1q32NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-catechin  (EXP)
(1->4)-beta-D-glucan  (ISO)
(R)-lipoic acid  (EXP)
(R)-noradrenaline  (EXP)
1,1-dichloroethene  (ISO)
1,2-dimethylhydrazine  (ISO)
17alpha-ethynylestradiol  (ISO)
17beta-estradiol  (EXP)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2-amino-2-deoxy-D-glucopyranose  (EXP)
2-bromohexadecanoic acid  (EXP)
2-methylcholine  (ISO)
3,3',5,5'-tetrabromobisphenol A  (EXP)
3,3',5-triiodo-L-thyronine  (EXP)
3-[3-(tert-butylsulfanyl)-1-(4-chlorobenzyl)-5-(propan-2-yl)-1H-indol-2-yl]-2,2-dimethylpropanoic acid  (EXP)
3-hydroxybutyric acid  (ISO)
3-isobutyl-1-methyl-7H-xanthine  (ISO)
4,4'-sulfonyldiphenol  (ISO)
4-hydroxy-TEMPO  (EXP)
4-hydroxyphenyl retinamide  (ISO)
5-fluorouracil  (ISO)
5-methyl-4-oxido-2-pyrazin-4-iumcarboxylic acid  (ISO)
6-chloro-2,3,4,9-tetrahydro-1H-carbazole-1-carboxamide  (EXP,ISO)
6-propyl-2-thiouracil  (EXP)
acetamide  (EXP)
acrylamide  (ISO)
Aflatoxin B2 alpha  (ISO)
AICA ribonucleotide  (EXP)
aldehydo-D-glucosamine  (EXP)
aldehydo-D-glucose  (EXP,ISO)
all-trans-retinoic acid  (ISO)
alpha-linolenic acid  (EXP)
alpha-Zearalanol  (EXP)
amitrole  (EXP)
ammonium chloride  (EXP)
antimycin A  (ISO)
antirheumatic drug  (ISO)
aristolochic acid A  (ISO)
arsenous acid  (ISO)
aspartame  (ISO)
ATP  (EXP,ISO)
atrazine  (EXP,ISO)
Bardoxolone methyl  (ISO)
beauvericin  (ISO)
benzo[a]pyrene  (ISO)
benzo[a]pyrene diol epoxide I  (ISO)
berberine  (ISO)
beta-D-glucosamine  (EXP)
bexarotene  (ISO)
bezafibrate  (EXP,ISO)
bis(2-ethylhexyl) phthalate  (EXP,ISO)
bisphenol A  (EXP,ISO)
cadmium atom  (EXP,ISO)
cadmium dichloride  (EXP,ISO)
candesartan  (EXP,ISO)
capsaicin  (EXP,ISO)
carbamazepine  (ISO)
Carbaprostacyclin  (EXP)
carbon monoxide  (ISO)
carbon nanotube  (ISO)
cerium trichloride  (ISO)
chlormequat chloride  (EXP)
chloroprene  (ISO)
chlorpyrifos  (ISO)
choline  (EXP,ISO)
chromium(6+)  (ISO)
ciglitazone  (ISO)
cisplatin  (ISO)
clobetasol  (ISO)
clofibrate  (EXP)
cobalt dichloride  (EXP,ISO)
copper(II) sulfate  (ISO)
cordycepin  (ISO)
crocidolite asbestos  (ISO)
Cuprizon  (EXP)
cyanides  (EXP)
cyanidin cation  (ISO)
cyclosporin A  (ISO)
D-glucose  (EXP,ISO)
DDE  (EXP)
dehydroepiandrosterone  (EXP)
desferrioxamine B  (ISO)
dexamethasone  (ISO)
diarsenic trioxide  (ISO)
Dibutyl phosphate  (ISO)
dichloroacetic acid  (ISO)
diclofenac  (ISO)
dicrotophos  (ISO)
diethyldithiocarbamic acid  (ISO)
dimethylarsinic acid  (ISO)
dioxygen  (EXP,ISO)
diquat  (ISO)
disodium selenite  (ISO)
diuron  (ISO)
doxorubicin  (EXP,ISO)
ebselen  (ISO)
edaravone  (EXP)
enniatin  (ISO)
epoxiconazole  (ISO)
ethanol  (EXP,ISO)
etoposide  (ISO)
fenofibrate  (EXP,ISO)
flutamide  (EXP)
folic acid  (ISO)
furan  (EXP)
Fusaric acid  (ISO)
gadolinium trichloride  (EXP)
Ganoderic acid A  (ISO)
gentamycin  (EXP)
geraniol  (EXP)
glucose  (EXP,ISO)
glutathione  (EXP)
gold atom  (ISO)
gold(0)  (ISO)
GW 501516  (EXP)
hexadecanoic acid  (EXP,ISO)
histamine  (ISO)
hydrogen peroxide  (EXP)
hydrogen sulfide  (ISO)
hydroxytyrosol  (EXP)
indometacin  (ISO)
indoxyl sulfate  (EXP)
inulin  (ISO)
isoprenaline  (EXP,ISO)
L-methionine  (EXP,ISO)
lactacystin  (EXP)
lanthanum trichloride  (ISO)
lead(0)  (ISO)
lenvatinib  (EXP)
lidocaine  (EXP)
linalool  (ISO)
linoleic acid  (EXP)
lipoic acid  (EXP)
lipopolysaccharide  (ISO)
losartan  (EXP,ISO)
lovastatin  (ISO)
menadione  (ISO)
metformin  (ISO)
methimazole  (EXP)
methotrexate  (ISO)
methylarsonic acid  (ISO)
methylmercury chloride  (ISO)
monosodium L-glutamate  (EXP,ISO)
Muraglitazar  (EXP)
myxothiazol  (ISO)
N,N-diethyl-m-toluamide  (EXP)
N-acetyl-L-cysteine  (EXP,ISO)
N-methyl-4-phenylpyridinium  (ISO)
N-methyl-N'-nitro-N-nitrosoguanidine  (ISO)
naringin  (ISO)
nickel atom  (ISO)
nicotinamide  (ISO)
NMN zwitterion  (EXP,ISO)
Nonylphenol  (EXP,ISO)
ochratoxin A  (EXP,ISO)
okadaic acid  (ISO)
oleic acid  (EXP)
oltipraz  (ISO)
paracetamol  (EXP,ISO)
paraquat  (ISO)
pentachlorophenol  (ISO)
perfluorodecanoic acid  (ISO)
perfluorooctane-1-sulfonic acid  (EXP,ISO)
perfluorooctanoic acid  (EXP,ISO)
permethrin  (EXP)
phenobarbital  (ISO)
phenylhydrazine  (ISO)
picrotoxin  (EXP)
pirinixic acid  (EXP,ISO)
potassium chromate  (ISO)
potassium cyanide  (EXP)
pregnenolone 16alpha-carbonitrile  (ISO)
propanal  (ISO)
propiconazole  (EXP)
prostaglandin D2  (ISO)
puerarin  (EXP)
Pyridostigmine bromide  (EXP)
quercetin  (ISO)
reactive oxygen species  (EXP,ISO)
resveratrol  (EXP,ISO)
rotenone  (EXP,ISO)
silicon dioxide  (ISO)
sodium arsenate  (ISO)
sodium arsenite  (EXP,ISO)
sodium benzoate  (EXP)
Soman  (EXP)
stavudine  (ISO)
streptozocin  (ISO)
succimer  (ISO)
sulfadimethoxine  (EXP)
sunitinib  (ISO)
superoxide  (EXP,ISO)
T-2 toxin  (EXP)
tamoxifen  (ISO)
telmisartan  (ISO)
Tesaglitazar  (EXP)
tetrachloroethene  (ISO)
tetrachloromethane  (EXP)
thapsigargin  (ISO)
thiazolidinediones  (EXP)
thimerosal  (ISO)
thioacetamide  (EXP)
thyroxine  (EXP)
titanium dioxide  (ISO)
tributylstannane  (ISO)
trichloroethene  (ISO)
trichostatin A  (EXP)
trilobatin  (EXP)
triphenyl phosphate  (ISO)
tris(2-butoxyethyl) phosphate  (ISO)
troglitazone  (EXP,ISO)
tunicamycin  (ISO)
urethane  (ISO)
valproic acid  (ISO)
vancomycin  (ISO)
vinclozolin  (EXP)
vincristine  (ISO)
vitamin E  (EXP)
zaragozic acid A  (EXP,ISO)
zearalenone  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
adaptive thermogenesis  (IBA)
C4-dicarboxylate transport  (ISO,ISS)
cellular response to amino acid starvation  (IEP)
cellular response to glucose stimulus  (IEP,ISO,ISS)
cellular response to hormone stimulus  (IEP)
cellular response to insulin stimulus  (IEP)
cellular response to lead ion  (IEP)
chloride transmembrane transport  (IEA)
glutamine metabolic process  (ISO,ISS)
glycolytic process  (ISO,ISS)
L-aspartate transmembrane transport  (IEA)
liver regeneration  (IEP)
long-chain fatty acid transport  (ISO)
macrophage differentiation  (ISO,ISS)
malate transmembrane transport  (IEA)
mitochondrial fission  (ISO,ISS)
mitochondrial transmembrane transport  (IBA,ISO,ISS)
mitochondrial transport  (IDA)
negative regulation of apoptotic process  (IMP)
negative regulation of calcium import into the mitochondrion  (ISO)
negative regulation of insulin secretion involved in cellular response to glucose stimulus  (IMP)
negative regulation of neuron apoptotic process  (ISO)
oxaloacetate(2-) transmembrane transport  (IEA)
positive regulation of cold-induced thermogenesis  (ISO,ISS)
positive regulation of response to biotic stimulus  (IMP)
proton transmembrane transport  (IEA)
reactive oxygen species metabolic process  (ISO,ISS)
regulation of mitochondrial membrane potential  (ISO)
response to cold  (IBA)
response to dexamethasone  (IEP)
response to fatty acid  (IEP)
response to glucose  (IEP)
response to hypoxia  (IEP,ISO)
response to superoxide  (IDA)
sulfate transmembrane transport  (IEA)

Cellular Component

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Uncoupling protein-2 attenuates glucose-stimulated insulin secretion in INS-1E insulinoma cells by lowering mitochondrial reactive oxygen species. Affourtit C, etal., Free Radic Biol Med. 2011 Mar 1;50(5):609-16. doi: 10.1016/j.freeradbiomed.2010.12.020. Epub 2010 Dec 21.
2. Testicular aging involves mitochondrial dysfunction as well as an increase in UCP2 levels and proton leak. Amaral S, etal., FEBS Lett. 2008 Dec 24;582(30):4191-6. doi: 10.1016/j.febslet.2008.11.020. Epub 2008 Nov 28.
3. Disruption of the uncoupling protein-2 gene in mice reveals a role in immunity and reactive oxygen species production. Arsenijevic D, etal., Nat Genet 2000 Dec;26(4):435-9.
4. Dynamic regulation of uncoupling protein 2 content in INS-1E insulinoma cells. Azzu V, etal., Biochim Biophys Acta. 2008 Oct;1777(10):1378-83. doi: 10.1016/j.bbabio.2008.07.001. Epub 2008 Jul 22.
5. Metabolic changes induced by cold stress in rat liver mitochondria. Bravo C, etal., J Bioenerg Biomembr 2001 Aug;33(4):289-301.
6. Uncoupling protein downregulation in doxorubicin-induced heart failure improves mitochondrial coupling but increases reactive oxygen species generation. Bugger H, etal., Cancer Chemother Pharmacol. 2011 Jun;67(6):1381-8. doi: 10.1007/s00280-010-1441-7. Epub 2010 Aug 31.
7. Loss of UCP2 impairs cold-induced non-shivering thermogenesis by promoting a shift toward glucose utilization in brown adipose tissue. Caron A, etal., Biochimie. 2017 Mar;134:118-126. doi: 10.1016/j.biochi.2017.01.006. Epub 2017 Jan 24.
8. Overexpression of the mitochondrial T3 receptor induces skeletal muscle atrophy during aging. Casas F, etal., PLoS One. 2009 May 20;4(5):e5631. doi: 10.1371/journal.pone.0005631.
9. An uncoupling protein 2 gene variant is associated with a raised body mass index but not Type II diabetes. Cassell PG, etal., Diabetologia. 1999 Jun;42(6):688-92.
10. Oral intake of rosiglitazone promotes a central antihypertensive effect via upregulation of peroxisome proliferator-activated receptor-gamma and alleviation of oxidative stress in rostral ventrolateral medulla of spontaneously hypertensive rats. Chan SH, etal., Hypertension. 2010 Jun;55(6):1444-53. Epub 2010 Apr 19.
11. Downregulation of genes involved in metabolism and oxidative stress in the peripheral leukocytes of Huntington's disease patients. Chang KH, etal., PLoS One. 2012;7(9):e46492. doi: 10.1371/journal.pone.0046492. Epub 2012 Sep 27.
12. Concordant mRNA expression of UCP-3, but not UCP-2, with mitochondrial thioesterase-1 in brown adipose tissue and skeletal muscle in db/db diabetic mice. Clapham JC, etal., Biochem Biophys Res Commun. 2001 Oct 12;287(5):1058-62.
13. UCP2 protects hypothalamic cells from TNF-alpha-induced damage. Degasperi GR, etal., FEBS Lett. 2008 Sep 3;582(20):3103-10. doi: 10.1016/j.febslet.2008.08.006. Epub 2008 Aug 12.
14. A long-term high-fat diet increases oxidative stress, mitochondrial damage and apoptosis in the inner ear of D-galactose-induced aging rats. Du Z, etal., Hear Res. 2012 May;287(1-2):15-24. doi: 10.1016/j.heares.2012.04.012. Epub 2012 Apr 21.
15. Superoxide activates mitochondrial uncoupling protein 2 from the matrix side. Studies using targeted antioxidants. Echtay KS, etal., J Biol Chem 2002 Dec 6;277(49):47129-35.
16. Superoxide activates mitochondrial uncoupling proteins. Echtay KS, etal., Nature 2002 Jan 3;415(6867):96-9.
17. Bile duct obstruction is associated with early postoperative upregulation of liver uncoupling protein-2 and reduced circulating glucose concentration in the rat. Enochsson L, etal., Nutrition. 2010 Apr;26(4):405-10. doi: 10.1016/j.nut.2009.05.005. Epub 2009 Jul 24.
18. A common polymorphism in the promoter of UCP2 is associated with decreased risk of obesity in middle-aged humans. Esterbauer H, etal., Nat Genet 2001 Jun;28(2):178-83.
19. Identification and distribution of uncoupling protein isoforms in the normal and diabetic rat kidney. Friederich M, etal., Adv Exp Med Biol. 2009;645:205-12.
20. Nutritional and hormonal regulation of uncoupling protein gene expression in rat adipocytes. Fukuda H, etal., J Nutr Sci Vitaminol (Tokyo). 2007 Oct;53(5):426-31.
21. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
22. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
23. Energy metabolism and expression of uncoupling proteins 1, 2, and 3 after 21 days of recovery from intracerebroventricular mouse leptin in rats. Gullicksen PS, etal., Physiol Behav 2002 Apr 1;75(4):473-82.
24. Linkage exclusion analysis of two candidate regions on chromosomes 7 and 11: leptin and UCP2/UCP3 are not QTLs for obesity in US Caucasians. Guo JJ, etal., Biochem Biophys Res Commun. 2005 Jul 1;332(2):602-8.
25. [UCP2 and UCP3 gene expression, heart function and oxygen cost of myocardial work changes during aging and ischemia-reperfusion] Hoshovs'ka IuV, etal., Fiziol Zh. 2009;55(3):26-36.
26. A common polymorphism of uncoupling protein 2 gene is associated with hypertension. Ji Q, etal., J Hypertens. 2004 Jan;22(1):97-102.
27. Increased hepatic UCP2 expression in rats with nonalcoholic steatohepatitis is associated with upregulation of Sp1 binding to its motif within the proximal promoter region. Jiang Y, etal., J Cell Biochem. 2008 Sep 1;105(1):277-89. doi: 10.1002/jcb.21827.
28. Antioxidant defenses in the rat placenta in late gestation: increased labyrinthine expression of superoxide dismutases, glutathione peroxidase 3, and uncoupling protein 2. Jones ML, etal., Biol Reprod. 2010 Aug 1;83(2):254-60. Epub 2010 Apr 14.
29. The effect of rat strain, diet composition and feeding period on the development of a nutritional model of non-alcoholic fatty liver disease in rats. Kucera O, etal., Physiol Res. 2011;60(2):317-28. Epub 2010 Nov 29.
30. High-density rat radiation hybrid maps containing over 24,000 SSLPs, genes, and ESTs provide a direct link to the rat genome sequence. Kwitek AE, etal., Genome Res. 2004 Apr;14(4):750-7
31. Induction of uncoupling protein 2 mRNA in beta-cells is stimulated by oxidation of fatty acids but not by nutrient oversupply. Li LX, etal., Endocrinology 2002 Apr;143(4):1371-7.
32. [The relationship between uncoupling protein 2 expression and myocardial high energy phosphates content in abdominal aorta constriction induced heart failure rats]. Li N, etal., Zhonghua Xin Xue Guan Bing Za Zhi. 2009 Dec;37(12):1108-12.
33. [Relationship between the expression of uncoupling protein 2 and the damage by oxygen free radicals in acute liver failure rats]. Liu JY, etal., Zhonghua Gan Zang Bing Za Zhi. 2011 Jan;19(1):55-7. doi: 10.3760/cma.j.issn.1007-3418.2011.01.015.
34. Both ischemic preconditioning and ghrelin administration protect hippocampus from ischemia/reperfusion and upregulate uncoupling protein-2. Liu Y, etal., BMC Physiol. 2009 Sep 22;9:17. doi: 10.1186/1472-6793-9-17.
35. Cloning of rat uncoupling protein-3 and uncoupling protein-2 cDNAs: their gene expression in rats fed high-fat diet. Matsuda J, etal., FEBS Lett 1997 Nov 24;418(1-2):200-4.
36. Uncoupling protein-2 prevents neuronal death and diminishes brain dysfunction after stroke and brain trauma. Mattiasson G, etal., Nat Med. 2003 Aug;9(8):1062-8. Epub 2003 Jul 13.
37. Supplementation of alpha-tocopherol improves cardiovascular risk factors via the insulin signalling pathway and reduction of mitochondrial reactive oxygen species in type II diabetic rats. Minamiyama Y, etal., Free Radic Res. 2008 Mar;42(3):261-71.
38. Bezafibrate-induced changes over time in the expression of uncoupling protein (UCP) mRNA in the tissues: a study in spontaneously type 2 diabetic rats with visceral obesity. Mori Y, etal., J Atheroscler Thromb. 2004;11(4):224-31.
39. Amelioration of high fructose-induced metabolic derangements by activation of PPARalpha. Nagai Y, etal., Am J Physiol Endocrinol Metab 2002 May;282(5):E1180-90.
40. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
41. Role of UCP2 expression after hepatic warm ischemia-reperfusion in the rat. Ninomiya M, etal., Gut Liver. 2011 Dec;5(4):486-92. Epub 2011 Nov 21.
42. Associations of the UCP2 gene locus with asymptomatic carotid atherosclerosis in middle-aged women. Oberkofler H, etal., Arterioscler Thromb Vasc Biol. 2005 Mar;25(3):604-10. Epub 2004 Dec 16.
43. Association between obesity and insulin resistance with UCP2-UCP3 gene variants in Spanish children and adolescents. Ochoa MC, etal., Mol Genet Metab. 2007 Dec;92(4):351-8. Epub 2007 Sep 17.
44. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
45. PID Annotation Import Pipeline Pipeline to import Pathway Interaction Database annotations from NCI into RGD
46. Genipin inhibits mitochondrial uncoupling protein 2 expression and ameliorates podocyte injury in diabetic mice. Qiu W, etal., PLoS One. 2012;7(7):e41391. Epub 2012 Jul 19.
47. GOA pipeline RGD automated data pipeline
48. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
49. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
50. Comprehensive gene review and curation RGD comprehensive gene curation
51. Functional polymorphisms of UCP2 and UCP3 are associated with a reduced prevalence of diabetic neuropathy in patients with type 1 diabetes. Rudofsky G Jr, etal., Diabetes Care. 2006 Jan;29(1):89-94.
52. Uncoupling protein-2 (UCP2) induces mitochondrial proton leak and increases susceptibility of non-alcoholic steatohepatitis (NASH) liver to ischaemia-reperfusion injury. Serviddio G, etal., Gut. 2008 Jul;57(7):957-65. doi: 10.1136/gut.2007.147496. Epub 2008 Feb 28.
53. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, etal., Proc Natl Acad Sci U S A. 2002 Dec 24;99(26):16899-903. Epub 2002 Dec 11.
54. Rat uncoupling protein 2 (UCP2): expression in obese ventromedial hypothalamus (VMH)-lesioned animals. Strobel A, etal., Int J Obes Relat Metab Disord 1998 Nov;22(11):1121-6.
55. Localization of 54 rat genes, and definition of new synteny groups conserved in the human and the rat. Szpirer C, etal., Mamm Genome 2000 Sep;11(9):729-35
56. Tentative Sequence Identification Numbers Tentative Sequence Data IDs. TIGR Gene Index, Rat Data
57. Genetic risk factors for renal failure among north Indian ESRD patients. Tripathi G, etal., Clin Biochem. 2008 May;41(7-8):525-31. Epub 2008 Jan 26.
58. Changes in FAT/CD36, UCP2, UCP3 and GLUT4 gene expression during lipid infusion in rat skeletal and heart muscle. Vettor R, etal., Int J Obes Relat Metab Disord 2002 Jun;26(6):838-47.
59. Protection of regenerating liver after partial hepatectomy from carbon tetrachloride hepatotoxicity in rats: roles of mitochondrial uncoupling protein 2 and ATP stores. Wu Q, etal., Dig Dis Sci. 2009 Sep;54(9):1918-25. doi: 10.1007/s10620-008-0650-y. Epub 2008 Dec 23.
60. [Study on the expression of uncoupling protein 2 in the kidney of the rats with hypothyroidism]. Xu J, etal., Zhongguo Wei Zhong Bing Ji Jiu Yi Xue. 2010 Dec;22(12):729-32.
61. Effect of berberine on expressions of uncoupling protein-2 mRNA and protein in hepatic tissue of non-alcoholic fatty liver disease in rats. Yang QH, etal., Chin J Integr Med. 2011 Mar;17(3):205-11. Epub 2011 Feb 27.
62. Association of genetic variants with chronic kidney disease in Japanese individuals. Yoshida T, etal., Clin J Am Soc Nephrol. 2009 May;4(5):883-90. Epub 2009 Apr 30.
63. Proliferation and differentiation of osteoblasts from the mandible of osteoporotic rats. Yu SJ, etal., Exp Biol Med (Maywood). 2012 Apr;237(4):395-406. doi: 10.1258/ebm.2011.011217.
64. Uncoupling protein-2 negatively regulates insulin secretion and is a major link between obesity, beta cell dysfunction, and type 2 diabetes. Zhang CY, etal., Cell 2001 Jun 15;105(6):745-55.
65. Cyanide-induced death of dopaminergic cells is mediated by uncoupling protein-2 up-regulation and reduced Bcl-2 expression. Zhang X, etal., Toxicol Appl Pharmacol. 2009 Jul 1;238(1):11-9. doi: 10.1016/j.taap.2009.03.020. Epub 2009 Apr 8.
66. Mitochondrial uncoupling protein 2 is regulated through heterogeneous nuclear ribonucleoprotein K in lead exposure models. Zhu G, etal., J Environ Sci Health C Toxicol Carcinog. 2021;39(1):1-16. doi: 10.1080/26896583.2020.1854596.
67. Genomic modulation of mitochondrial respiratory genes in the hypertrophied heart reflects adaptive changes in mitochondrial and contractile function. Zungu M, etal., Am J Physiol Heart Circ Physiol. 2007 Nov;293(5):H2819-25. Epub 2007 Aug 17.
Additional References at PubMed
PMID:9512646   PMID:9666083   PMID:12222743   PMID:12397391   PMID:12435081   PMID:12588051   PMID:12588052   PMID:12603007   PMID:12706490   PMID:12756242   PMID:12785014   PMID:12912909  
PMID:12967645   PMID:14511123   PMID:14576981   PMID:14651853   PMID:15464300   PMID:15474499   PMID:15493555   PMID:15563984   PMID:15682648   PMID:15694840   PMID:15713687   PMID:15772780  
PMID:15782323   PMID:15878969   PMID:16079144   PMID:16282353   PMID:16329595   PMID:16387447   PMID:16845607   PMID:17468330   PMID:17824844   PMID:18226608   PMID:18290312   PMID:18314881  
PMID:18439413   PMID:18614015   PMID:18626658   PMID:19082571   PMID:19230380   PMID:19762685   PMID:19774674   PMID:20010438   PMID:20014488   PMID:21162199   PMID:21179742   PMID:21855553  
PMID:22292025   PMID:22588935   PMID:22736029   PMID:22768304   PMID:22849356   PMID:22930490   PMID:23084643   PMID:23087176   PMID:23297375   PMID:23372044   PMID:23515048   PMID:23800309  
PMID:25132457   PMID:25703824   PMID:25873251   PMID:25925080   PMID:26173855   PMID:26621256   PMID:26664262   PMID:26903064   PMID:26968794   PMID:27356851   PMID:28222054   PMID:28428961  
PMID:28640254   PMID:28993954   PMID:29025747   PMID:29559841   PMID:30159115   PMID:30665716   PMID:31022254   PMID:31081966   PMID:31702042   PMID:31771728   PMID:32120777   PMID:32394310  
PMID:33463495   PMID:33576345   PMID:34625529   PMID:35771638   PMID:38134189   PMID:38301949  


Genomics

Comparative Map Data
Ucp2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81164,251,373 - 164,257,742 (+)NCBIGRCr8
mRatBN7.21154,839,242 - 154,845,612 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1154,839,209 - 154,845,611 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1162,834,282 - 162,840,647 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01170,014,387 - 170,020,752 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01162,888,256 - 162,894,621 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01165,506,375 - 165,512,744 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1165,506,361 - 165,512,744 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01171,707,625 - 171,713,991 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41157,925,514 - 157,928,222 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11158,000,971 - 158,007,311 (+)NCBI
Celera1152,922,529 - 152,928,898 (+)NCBICelera
RH 3.4 Map11261.4RGD
Cytogenetic Map1q32NCBI
UCP2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381173,974,672 - 73,983,202 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1173,974,672 - 73,982,843 (-)EnsemblGRCh38hg38GRCh38
GRCh371173,685,717 - 73,694,247 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361173,363,364 - 73,371,537 (-)NCBINCBI36Build 36hg18NCBI36
Build 341173,363,363 - 73,371,537NCBI
Celera1170,992,461 - 71,000,634 (-)NCBICelera
Cytogenetic Map11q13.4NCBI
HuRef1169,981,482 - 69,989,655 (-)NCBIHuRef
CHM1_11173,569,569 - 73,577,739 (-)NCBICHM1_1
T2T-CHM13v2.01173,903,817 - 73,912,347 (-)NCBIT2T-CHM13v2.0
Ucp2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm397100,142,565 - 100,148,832 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl7100,142,544 - 100,151,227 (+)EnsemblGRCm39 Ensembl
GRCm387100,493,337 - 100,499,629 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl7100,493,337 - 100,502,020 (+)EnsemblGRCm38mm10GRCm38
MGSCv377107,641,854 - 107,650,682 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv367100,367,446 - 100,376,102 (+)NCBIMGSCv36mm8
Celera7100,830,936 - 100,839,747 (+)NCBICelera
Cytogenetic Map7E2NCBI
cM Map754.36NCBI
Ucp2
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495541417,592,914 - 17,596,477 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495541417,592,914 - 17,596,477 (+)NCBIChiLan1.0ChiLan1.0
UCP2
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2974,916,276 - 74,923,240 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11175,960,189 - 75,967,154 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01169,047,397 - 69,056,056 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11172,354,529 - 72,363,185 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1172,354,529 - 72,363,185 (-)Ensemblpanpan1.1panPan2
UCP2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12124,304,410 - 24,311,392 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2124,304,457 - 24,311,128 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha2124,075,387 - 24,078,118 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.02124,510,583 - 24,517,796 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl2124,510,627 - 24,520,713 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.12124,310,265 - 24,312,996 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02124,510,181 - 24,512,912 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02124,425,514 - 24,428,245 (+)NCBIUU_Cfam_GSD_1.0
Ucp2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440494761,460,097 - 61,466,425 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049364983,059,297 - 3,066,197 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049364983,059,700 - 3,066,112 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
UCP2
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl98,358,025 - 8,365,547 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.198,358,559 - 8,364,552 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.299,147,996 - 9,155,017 (-)NCBISscrofa10.2Sscrofa10.2susScr3
Pig Cytomap9p24-p21NCBI
UCP2
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1165,238,311 - 65,246,841 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl165,235,775 - 65,246,450 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366604360,637,629 - 60,646,847 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Ucp2
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248173,067,320 - 3,075,043 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046248173,067,358 - 3,075,045 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Ucp2
31 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:45
Count of miRNA genes:36
Interacting mature miRNAs:40
Transcripts:ENSRNOT00000024156
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
61442Strs1Sensitivity to stroke QTL 17.4cerebrum integrity trait (VT:0010549)post-insult time to onset of cerebrovascular lesion (CMO:0002343)1121767634166767634Rat
1578778Pur4Proteinuria QTL 43.30.003urine total protein amount (VT:0000032)urine total protein excretion rate (CMO:0000756)1150700247252085048Rat
1354646Kidm18Kidney mass QTL 185.7kidney mass (VT:0002707)calculated kidney weight (CMO:0000160)1151162512256448636Rat
1578780Cm52Cardiac mass QTL 523.30.0001heart mass (VT:0007028)heart wet weight (CMO:0000069)181591954219808434Rat
1578654Bss10Bone structure and strength QTL 104femur morphology trait (VT:0000559)femoral neck cortical cross-sectional area (CMO:0001702)149393172159356837Rat
2302378Insul11Insulin level QTL 113.25blood insulin amount (VT:0001560)serum insulin level (CMO:0000358)1144267353251128347Rat
1598866Bp287Blood pressure QTL 2875.1arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1121006655166006655Rat
1578770Stresp23Stress response QTL 23kidney sympathetic nerve activity (VT:0004050)stimulated renal sympathetic nerve activity to basal renal sympathetic nerve activity ratio (CMO:0001786)1123350408182418476Rat
70160Bw18Body weight QTL 185.7body mass (VT:0001259)body weight (CMO:0000012)1144267353196383668Rat
7794788Mcs32Mammary carcinoma susceptibility QTL 322.61mammary gland integrity trait (VT:0010552)mammary tumor incidence/prevalence measurement (CMO:0000946)1115540693238914717Rat
631199Cm23Cardiac mass QTL 234.60.0004heart left ventricle mass (VT:0007031)heart left ventricle wet weight (CMO:0000071)1115585465172949803Rat
1354636Lmblg1Limb length QTL 16.4tibia length (VT:0004357)tibia length (CMO:0000450)1151162512201278233Rat
1598850Bp297Blood pressure QTL 2972.1arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1121006655166006655Rat
1549837Hcar15Hepatocarcinoma resistance QTL 150.05liver integrity trait (VT:0010547)liver tumorous lesion number (CMO:0001068)1153136852260522016Rat
1598853Memor3Memory QTL 34.5exploratory behavior trait (VT:0010471)total horizontal distance resulting from voluntary locomotion in an experimental apparatus (CMO:0001443)1143506580212458660Rat
1354634Kidm12Kidney mass QTL 123.9kidney mass (VT:0002707)right kidney wet weight (CMO:0000082)1151162512201278233Rat
1578759Uae30Urinary albumin excretion QTL 303.30.003urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)1150700247252085048Rat
61343Bp28Blood pressure QTL 28arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1151646613196646613Rat
724521Uae1Urinary albumin excretion QTL 13.80.0001urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)190508614173018436Rat
1358902Bw47Body weight QTL 471.67body mass (VT:0001259)body weight (CMO:0000012)190508614180359386Rat
61348Bp30Blood pressure QTL 302.4arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1144017057197814409Rat
2303622Vencon6Ventilatory control QTL 60.001respiration trait (VT:0001943)respiration rate (CMO:0000289)1154561505199561505Rat
8655649Arrd1Age-related retinal degeneration QTL 14.89retinal layer morphology trait (VT:0003727)percentage of study population developing retinopathy during a period of time (CMO:0002453)1100357752183970443Rat
7771612Cm80Cardiac mass QTL 808.4heart left ventricle mass (VT:0007031)heart left ventricle weight (CMO:0000776)1149448574221264292Rat
631202Gluco13Glucose level QTL 130.0001blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)1131763437159756369Rat
731168Bp154Blood pressure QTL 1543.4arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)194642644214537671Rat
631205Bp196Blood pressure QTL 19640.0001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)1118944897199050459Rat
1300158Bp173Blood pressure QTL 1733.48arterial blood pressure trait (VT:2000000)blood pressure time series experimental set point of the baroreceptor response (CMO:0002593)1115540693185145286Rat
631206Niddm40Non-insulin dependent diabetes mellitus QTL 40blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)1136745990163747690Rat
737828Hcas3Hepatocarcinoma susceptibility QTL 34.9liver integrity trait (VT:0010547)liver tumorous lesion volume to total liver volume ratio (CMO:0001082)1144267353222987745Rat
1331749Hrtrt11Heart rate QTL 112.973heart pumping trait (VT:2000009)heart rate (CMO:0000002)194494440198211706Rat
1354661Bw33Body weight QTL 335.2body mass (VT:0001259)body weight (CMO:0000012)1151162512256448636Rat
1358886Bp260Blood pressure QTL 2603.67arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)1151162766225824951Rat
1331751Bp199Blood pressure QTL 1993.60022arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)194494440181830018Rat
9685799Bp375Blood pressure QTL 375arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1125611501170611501Rat
2293140Bp313Blood pressure QTL 313arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1121833674166833674Rat
724531Uae5Urinary albumin excretion QTL 54urine albumin amount (VT:0002871)urine albumin level (CMO:0000130)1150700142252085212Rat
9685802Bp376Blood pressure QTL 376arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1126540680171540680Rat
1641895Bp298Blood pressure QTL 298arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)1123350408182418476Rat
70209Niddm23Non-insulin dependent diabetes mellitus QTL 232.82blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)194494440198324465Rat
634315Niddm45Non-insulin dependent diabetes mellitus QTL 457.16blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)1144267916172949660Rat
634314Niddm44Non-insulin dependent diabetes mellitus QTL 44blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)149393289199050459Rat
61379Bp44Blood pressure QTL 4419.2arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1144267916174133260Rat
1331793Bp200Blood pressure QTL 2003.71601arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)194494440172949803Rat
2313060Bss71Bone structure and strength QTL 712.60.0001long bone metaphysis morphology trait (VT:0000133)tibia midshaft total cross-sectional area (CMO:0001715)1118944747163944747Rat
6893347Bw98Body weight QTL 980.20.53body mass (VT:0001259)body weight (CMO:0000012)1133680936178680936Rat
1354591Cm36Cardiac mass QTL 364.1heart left ventricle mass (VT:0007031)calculated heart weight (CMO:0000073)1102813953201278233Rat
724550Thym3Thymus enlargement QTL 37.820.001thymus mass (VT:0004954)thymus weight to body weight ratio (CMO:0000612)1136829932181829932Rat
71118Thym1Thymus enlargement QTL 110.170.001thymus mass (VT:0004954)thymus weight to body weight ratio (CMO:0000612)1136829932181829932Rat
7421630Bp362Blood pressure QTL 3620.001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)1118608292241799120Rat
70225Bp58Blood pressure QTL 583.3arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)132356093162846471Rat
10059597Bp377Blood pressure QTL 3773.420.025arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)132737458199368955Rat
631519Pia11Pristane induced arthritis QTL 115.3joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1136830018181830018Rat
6893361Bw104Body weight QTL 1040.590.27body mass (VT:0001259)body weight (CMO:0000012)1133680936178680936Rat
738006Anxrr14Anxiety related response QTL 1440.00035locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)1130636910175636910Rat
1558645Bw55Body weight QTL 553.20.004body mass (VT:0001259)body weight (CMO:0000012)1133680936178680936Rat
1354615Cm32Cardiac mass QTL 325.2heart left ventricle mass (VT:0007031)heart left ventricle wet weight (CMO:0000071)1102813953201278233Rat
634348Bp138Blood pressure QTL 138arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1125611501168883176Rat
1354610Bw34Body weight QTL 344.1body mass (VT:0001259)body weight (CMO:0000012)1151162512256448636Rat
738028Anxrr12Anxiety related response QTL 124.90.00001locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)1130636910175636910Rat
1354620Kidm19Kidney mass QTL 194kidney mass (VT:0002707)calculated kidney weight (CMO:0000160)1151162512201278233Rat
631654Bp107Blood pressure QTL 107arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1125611501170611501Rat
631544Bp84Blood pressure QTL 845.6arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1123350408181759564Rat
631549Bp89Blood pressure QTL 895.7arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1123350581201284552Rat
1358189Cstrr1Cold stress response QTL 10.0001catecholamine amount (VT:0010543)urine norepinephrine level (CMO:0001629)1123350408182418476Rat
1354606Bp246Blood pressure QTL 2463.6arterial blood pressure trait (VT:2000000)pulse pressure (CMO:0000292)1102813953218753816Rat
1354602Bw35Body weight QTL 3512.2body mass (VT:0001259)body weight (CMO:0000012)1151162512201278233Rat

Markers in Region
D1Wox38  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21154,820,746 - 154,820,912 (+)MAPPERmRatBN7.2
Rnor_6.01165,487,882 - 165,488,045NCBIRnor6.0
Rnor_5.01171,688,536 - 171,688,699UniSTSRnor5.0
RGSC_v3.41157,900,971 - 157,901,134UniSTSRGSC3.4
Celera1152,903,290 - 152,903,448UniSTS
Cytogenetic Map1q32UniSTS
RH94758  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21154,842,533 - 154,843,065 (+)MAPPERmRatBN7.2
Rnor_6.01165,509,666 - 165,510,197NCBIRnor6.0
Rnor_5.01171,710,912 - 171,711,443UniSTSRnor5.0
RGSC_v3.41157,925,441 - 157,925,972UniSTSRGSC3.4
Celera1152,925,820 - 152,926,351UniSTS
RH 3.4 Map11261.4UniSTS
Cytogenetic Map1q32UniSTS
PMC297000P1  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21154,842,679 - 154,842,902 (+)MAPPERmRatBN7.2
Rnor_6.01165,509,812 - 165,510,034NCBIRnor6.0
Rnor_5.01171,711,058 - 171,711,280UniSTSRnor5.0
RGSC_v3.41157,925,587 - 157,925,809UniSTSRGSC3.4
Celera1152,925,966 - 152,926,188UniSTS
Cytogenetic Map1q32UniSTS


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High 6 6 2 6
Medium 3 43 43 27 17 27 1 4 66 30 41 11 1
Low 8 8 8 7 7 8 5 7
Below cutoff

Sequence


RefSeq Acc Id: ENSRNOT00000024156   ⟹   ENSRNOP00000024156
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1154,839,209 - 154,845,611 (+)Ensembl
Rnor_6.0 Ensembl1165,506,361 - 165,512,744 (+)Ensembl
RefSeq Acc Id: NM_019354   ⟹   NP_062227
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81164,251,373 - 164,257,742 (+)NCBI
mRatBN7.21154,839,242 - 154,845,612 (+)NCBI
Rnor_6.01165,506,375 - 165,512,744 (+)NCBI
Rnor_5.01171,707,625 - 171,713,991 (+)NCBI
RGSC_v3.41157,925,514 - 157,928,222 (+)RGD
Celera1152,922,529 - 152,928,898 (+)NCBI
Sequence:
RefSeq Acc Id: NP_062227   ⟸   NM_019354
- UniProtKB: O88183 (UniProtKB/Swiss-Prot),   O70178 (UniProtKB/Swiss-Prot),   Q6GST1 (UniProtKB/Swiss-Prot),   P56500 (UniProtKB/Swiss-Prot),   A6I6P2 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSRNOP00000024156   ⟸   ENSRNOT00000024156

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P56500-F1-model_v2 AlphaFold P56500 1-309 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13690244
Promoter ID:EPDNEW_R767
Type:multiple initiation site
Name:Ucp2_1
Description:uncoupling protein 2
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.01165,506,375 - 165,506,435EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:3932 AgrOrtholog
BioCyc Gene G2FUF-58334 BioCyc
Ensembl Genes ENSRNOG00000017854 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
  ENSRNOG00065024250 UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000024156 ENTREZGENE
  ENSRNOT00000024156.6 UniProtKB/Swiss-Prot
  ENSRNOT00065041580 UniProtKB/Swiss-Prot
Gene3D-CATH 1.50.40.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
IMAGE_CLONE IMAGE:6920447 IMAGE-MGC_LOAD
InterPro Mit_carrier UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Mitochondrial_sb/sol_carrier UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Mt_carrier_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:54315 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
MGC_CLONE MGC:72850 IMAGE-MGC_LOAD
NCBI Gene 54315 ENTREZGENE
PANTHER MITOCHONDRIAL DICARBOXYLATE CARRIER-RELATED UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  MITOCHONDRIAL UNCOUPLING PROTEIN 2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam Mito_carr UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Ucp2 PhenoGen
PRINTS MTUNCOUPLING UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE SOLCAR UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
RatGTEx ENSRNOG00000017854 RatGTEx
  ENSRNOG00065024250 RatGTEx
Superfamily-SCOP Mitochondrial carrier UniProtKB/TrEMBL, UniProtKB/Swiss-Prot
TIGR TC220476
UniProt A6I6N8_RAT UniProtKB/TrEMBL
  A6I6P2 ENTREZGENE, UniProtKB/TrEMBL
  A6I6P3_RAT UniProtKB/TrEMBL
  O70178 ENTREZGENE
  O88183 ENTREZGENE
  P56500 ENTREZGENE
  Q6GST1 ENTREZGENE
  UCP2_RAT UniProtKB/Swiss-Prot
UniProt Secondary O70178 UniProtKB/Swiss-Prot
  O88183 UniProtKB/Swiss-Prot
  Q6GST1 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2016-05-05 Ucp2  uncoupling protein 2  Ucp2  uncoupling protein 2 (mitochondrial, proton carrier)  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2006-03-30 Ucp2  uncoupling protein 2 (mitochondrial, proton carrier)    uncoupling protein 2  Name updated 1299863 APPROVED
2002-06-10 Ucp2  Uncoupling protein 2, mitochondrial      Symbol and Name status set to approved 70586 APPROVED

RGD Curation Notes
Note Type Note Reference
gene_regulation increased proton transport and uncoupling activity is induced by superoxide 727448