Ube2i (ubiquitin-conjugating enzyme E2I) - Rat Genome Database

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Gene: Ube2i (ubiquitin-conjugating enzyme E2I) Rattus norvegicus
Analyze
Symbol: Ube2i
Name: ubiquitin-conjugating enzyme E2I
RGD ID: 3926
Description: Enables bHLH transcription factor binding activity; ionotropic glutamate receptor binding activity; and ubiquitin-like protein transferase activity. Involved in several processes, including positive regulation of DNA-binding transcription factor activity; protein sumoylation; and regulation of signal transduction. Located in dendrite and nucleus. Orthologous to human UBE2I (ubiquitin conjugating enzyme E2 I); PARTICIPATES IN altered ubiquitin/proteasome degradation pathway; Alzheimer's disease pathway; sumoylation pathway; INTERACTS WITH (+)-pilocarpine; 2,4-dinitrotoluene; 6-propyl-2-thiouracil.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: MGC105476; RING-type E3 SUMO transferase UBC9; SUMO-conjugating enzyme UBC9; SUMO-protein ligase; Ubc9; UbcE2A; ubiquitin carrier protein 9; ubiquitin carrier protein I; Ubiquitin conjugating enzyme E2I; Ubiquitin conjugating enzyme E2I (homologous to yeast UBC9); ubiquitin-conjugating enzyme E2I (UBC9 homolog, yeast); ubiquitin-conjugating enzyme UbcE2A; ubiquitin-protein ligase I
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Candidate Gene For: Bmd4
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81014,782,245 - 14,802,911 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl1070,199,041 - 70,199,866 (+)EnsemblGRCr8
GRCr8 Ensembl1014,783,651 - 14,799,422 (-)EnsemblGRCr8
mRatBN7.21014,277,749 - 14,294,681 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1014,277,749 - 14,295,136 (-)EnsemblmRatBN7.2
mRatBN7.2 Ensembl1069,701,618 - 69,702,443 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx1019,019,943 - 19,034,557 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01018,508,805 - 18,523,419 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01014,008,012 - 14,022,626 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.01014,618,615 - 14,639,274 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1014,620,531 - 14,630,151 (-)Ensemblrn6Rnor6.0
Rnor_5.01014,436,200 - 14,456,889 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.41014,509,948 - 14,524,551 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera1013,951,568 - 13,966,171 (-)NCBICelera
RGSC_v3.11014,509,950 - 14,524,551 (-)NCBI
Cytogenetic Map10q12NCBI
JBrowse:




Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-pilocarpine  (EXP)
(-)-citrinin  (ISO)
(S)-nicotine  (ISO)
1,2-dichloroethane  (ISO)
1,2-dimethylhydrazine  (ISO)
1-chloro-2,4-dinitrobenzene  (ISO)
17beta-estradiol  (ISO)
1H-pyrazole  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (ISO)
2,4-dinitrotoluene  (EXP)
2-naphthylamine  (ISO)
4,4'-sulfonyldiphenol  (ISO)
4-hydroxynon-2-enal  (ISO)
6-propyl-2-thiouracil  (EXP)
acrylamide  (ISO)
actinomycin D  (ISO)
aflatoxin B1  (ISO)
all-trans-retinoic acid  (ISO)
amitrole  (EXP)
ammonium chloride  (EXP)
antirheumatic drug  (ISO)
arsane  (ISO)
arsenic atom  (ISO)
arsenous acid  (ISO)
benzo[a]pyrene  (ISO)
bilirubin IXalpha  (ISO)
bis(2-ethylhexyl) phthalate  (EXP)
bisphenol A  (EXP,ISO)
calcium atom  (EXP)
calcium(0)  (EXP)
CARBENOXOLONE  (EXP)
carbon nanotube  (ISO)
CGP 52608  (ISO)
chlorpyrifos  (ISO)
cholesterol  (ISO)
ciguatoxin CTX1B  (ISO)
clofibrate  (EXP)
cobalt dichloride  (ISO)
cocaine  (ISO)
copper atom  (ISO)
copper(0)  (ISO)
D-gluconic acid  (EXP)
DDE  (ISO)
deoxycholic acid  (EXP)
dexamethasone  (ISO)
diarsenic trioxide  (ISO)
dibutyl phthalate  (ISO)
dioxygen  (EXP,ISO)
dorsomorphin  (ISO)
doxorubicin  (ISO)
emodin  (ISO)
endosulfan  (ISO)
ethanol  (ISO)
fipronil  (EXP)
flavonoids  (EXP)
folic acid  (ISO)
genistein  (ISO)
gentamycin  (EXP)
glyphosate  (ISO)
ivermectin  (ISO)
lipopolysaccharide  (EXP,ISO)
methimazole  (EXP)
methotrexate  (ISO)
methylmercury chloride  (ISO)
mevinphos  (EXP)
mono(2-ethylhexyl) phthalate  (ISO)
monobenzyl phthalate  (ISO)
Monobutylphthalate  (ISO)
monoethyl phthalate  (ISO)
monosodium L-glutamate  (EXP)
nicotine  (ISO)
nimesulide  (EXP)
nitrates  (ISO)
Nutlin-3  (ISO)
ochratoxin A  (ISO)
paracetamol  (ISO)
pentachlorophenol  (ISO)
phenobarbital  (ISO)
phenylmercury acetate  (ISO)
phlorizin  (ISO)
pirinixic acid  (ISO)
prasugrel hydrochloride  (EXP)
pregnenolone 16alpha-carbonitrile  (EXP)
propiconazole  (ISO)
rifampicin  (EXP)
SB 431542  (ISO)
sodium arsenate  (ISO)
succimer  (ISO)
sulfadimethoxine  (EXP)
sunitinib  (ISO)
thapsigargin  (EXP)
thioacetamide  (EXP)
topotecan  (ISO)
trichostatin A  (ISO)
triphenyl phosphate  (ISO)
trovafloxacin  (ISO)
valproic acid  (ISO)
vincristine  (ISO)
vorinostat  (ISO)
zinc sulfate  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

References

References - curated
# Reference Title Reference Citation
1. TWIST1 regulates the activity of ubiquitin proteasome system via the miR-199/214 cluster in human end-stage dilated cardiomyopathy. Baumgarten A, etal., Int J Cardiol. 2013 Sep 30;168(2):1447-52. doi: 10.1016/j.ijcard.2012.12.094. Epub 2013 Jan 27.
2. The giant fibrillar center: a nucleolar structure enriched in upstream binding factor (UBF) that appears in transcriptionally more active sensory ganglia neurons. Casafont I, etal., J Struct Biol. 2007 Sep;159(3):451-61. Epub 2007 May 25.
3. Tollip is a mediator of protein sumoylation. Ciarrocchi A, etal., PLoS One. 2009;4(2):e4404. Epub 2009 Feb 9.
4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
5. Ubc9 is a novel modulator of the induction properties of glucocorticoid receptors. Kaul S, etal., J Biol Chem. 2002 Apr 12;277(15):12541-9. Epub 2002 Jan 25.
6. Degradation of E2A proteins through a ubiquitin-conjugating enzyme, UbcE2A. Kho CJ, etal., J Biol Chem 1997 Feb 7;272(6):3845-51.
7. Modification of Ran GTPase-activating protein by the small ubiquitin-related modifier SUMO-1 requires Ubc9, an E2-type ubiquitin-conjugating enzyme homologue. Lee GW, etal., J Biol Chem. 1998 Mar 13;273(11):6503-7.
8. Defective ubiquitination of cerebral proteins in Alzheimer's disease. Lopez Salon M, etal., J Neurosci Res 2000 Oct 15;62(2):302-10.
9. SUMOylation regulates kainate-receptor-mediated synaptic transmission. Martin S, etal., Nature. 2007 May 17;447(7142):321-5. Epub 2007 May 7.
10. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
11. A role for Ubc9 in tumorigenesis. Mo YY, etal., Oncogene. 2005 Apr 14;24(16):2677-83.
12. Characterization of a new SUMO-1 nuclear body (SNB) enriched in pCREB, CBP, c-Jun in neuron-like UR61 cells. Navascues J, etal., Chromosoma. 2007 Oct;116(5):441-51. Epub 2007 May 26.
13. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
14. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
15. GOA pipeline RGD automated data pipeline
16. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
17. Involvement of ubiquitination and sumoylation in bladder lesions induced by persistent long-term low dose ionizing radiation in humans. Romanenko AM, etal., J Urol. 2006 Feb;175(2):739-43.
18. Rhes, a striatal specific protein, mediates mutant-huntingtin cytotoxicity. Subramaniam S, etal., Science. 2009 Jun 5;324(5932):1327-30. doi: 10.1126/science.1172871.
19. Tentative Sequence Identification Numbers Tentative Sequence Data IDs. TIGR Gene Index, Rat Data
20. Interactions of the mineralocorticoid receptor--within and without. Yang J and Fuller PJ, Mol Cell Endocrinol. 2012 Mar 24;350(2):196-205. doi: 10.1016/j.mce.2011.07.001. Epub 2011 Jul 18.
Additional References at PubMed
PMID:9223278   PMID:9409784   PMID:9885291   PMID:10562557   PMID:10562558   PMID:12477932   PMID:14739995   PMID:14752048   PMID:15489334   PMID:15539428   PMID:15539951   PMID:15611122  
PMID:15660128   PMID:15802564   PMID:16127449   PMID:16631117   PMID:17087506   PMID:17911097   PMID:18555800   PMID:18681895   PMID:19039338   PMID:19407830   PMID:19744555   PMID:19955185  
PMID:20167237   PMID:20209145   PMID:21518833   PMID:21616059   PMID:21630459   PMID:21968017   PMID:22082260   PMID:22658674   PMID:26620705   PMID:30772377   PMID:38955308  


Genomics

Comparative Map Data
Ube2i
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81014,782,245 - 14,802,911 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl1070,199,041 - 70,199,866 (+)EnsemblGRCr8
GRCr8 Ensembl1014,783,651 - 14,799,422 (-)EnsemblGRCr8
mRatBN7.21014,277,749 - 14,294,681 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1014,277,749 - 14,295,136 (-)EnsemblmRatBN7.2
mRatBN7.2 Ensembl1069,701,618 - 69,702,443 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx1019,019,943 - 19,034,557 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01018,508,805 - 18,523,419 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01014,008,012 - 14,022,626 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.01014,618,615 - 14,639,274 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1014,620,531 - 14,630,151 (-)Ensemblrn6Rnor6.0
Rnor_5.01014,436,200 - 14,456,889 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.41014,509,948 - 14,524,551 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera1013,951,568 - 13,966,171 (-)NCBICelera
RGSC_v3.11014,509,950 - 14,524,551 (-)NCBI
Cytogenetic Map10q12NCBI
UBE2I
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38161,309,152 - 1,327,017 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl161,291,444 - 1,327,018 (+)Ensemblhg38GRCh38
GRCh37161,359,153 - 1,377,018 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36161,299,181 - 1,315,391 (+)NCBIBuild 36Build 36hg18NCBI36
Build 34161,299,180 - 1,315,391NCBI
Celera161,573,488 - 1,589,693 (+)NCBICelera
Cytogenetic Map16p13.3NCBI
HuRef161,287,961 - 1,305,367 (+)NCBIHuRef
CHM1_1161,359,074 - 1,376,964 (+)NCBICHM1_1
T2T-CHM13v2.0161,325,332 - 1,343,194 (+)NCBIT2T-CHM13v2.0
Ube2i
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391725,479,484 - 25,494,965 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1725,479,482 - 25,493,856 (-)EnsemblGRCm39 EnsemblGRCm39
GRCm381725,260,510 - 25,275,799 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1725,261,916 - 25,274,622 (-)Ensemblmm10GRCm38
MGSCv371725,397,456 - 25,411,255 (-)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv361724,988,111 - 25,001,891 (-)NCBIMGSCv36mm8
Celera1725,787,805 - 25,801,616 (-)NCBICelera
Cytogenetic Map17A3.3NCBI
cM Map1712.53NCBI
Ube2i
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495544215,901,980 - 15,913,037 (-)Ensembl
ChiLan1.0NW_00495544215,902,026 - 15,913,033 (-)NCBIChiLan1.0ChiLan1.0
UBE2I
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2181,572,047 - 1,588,221 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1165,358,365 - 5,374,530 (+)NCBINHGRI_mPanPan1
PanPan1.1161,365,291 - 1,382,575 (+)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl161,367,288 - 1,382,575 (+)EnsemblpanPan2panpan1.1
UBE2I
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1639,440,123 - 39,453,688 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl639,440,314 - 39,817,588 (-)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha640,707,767 - 40,719,921 (-)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.0639,786,145 - 39,798,312 (-)NCBIROS_Cfam_1.0ROS_Cfam_1.0
UMICH_Zoey_3.1639,462,778 - 39,474,925 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0639,435,400 - 39,447,553 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0639,913,736 - 39,925,904 (-)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Ube2i
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024409344104,133,975 - 104,147,758 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049366942,561,681 - 2,576,647 (-)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_0049366942,561,701 - 2,571,284 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
UBE2I
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1340,556,556 - 40,586,382 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2341,899,856 - 41,966,997 (+)NCBISscrofa10.2Sscrofa10.2susScr3
UBE2I
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.151,203,513 - 1,216,662 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl51,200,018 - 1,216,741 (+)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Vero_WHO_p1.0NW_02366606829,867,995 - 29,884,946 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Ube2i
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046249132,025,528 - 2,041,690 (+)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
HetGla 1.0NW_0046249132,025,241 - 2,041,394 (+)NCBIHetGla 1.0HetGla 1.0hetGla2

Variants

.
Variants in Ube2i
63 total Variants
miRNA Target Status (No longer updated)

Confirmed Target Of
miRNA GeneMature miRNAMethod NameResult TypeData TypeSupport TypePMID
Mir199a2rno-miR-199a-5pMirtarbaseexternal_infoLuciferase reporter assayFunctional MTI20965886

Predicted Target Of
Summary Value
Count of predictions:225
Count of miRNA genes:151
Interacting mature miRNAs:175
Transcripts:ENSRNOT00000024406
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
9589136Insul27Insulin level QTL 2710.460.001blood insulin amount (VT:0001560)plasma insulin level (CMO:0000342)101147401056474010Rat
8662860Vetf10Vascular elastic tissue fragility QTL 10artery integrity trait (VT:0010639)number of ruptures of the internal elastic lamina of the abdominal aorta and iliac arteries (CMO:0002562)10615418273453136Rat
2313066Bss63Bone structure and strength QTL 631.40.0001tibia strength trait (VT:1000284)bone polar moment of inertia (CMO:0001558)10538701450387014Rat
631554Bp133Blood pressure QTL 1330.005arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1074336463851208Rat
2313064Bmd71Bone mineral density QTL 710.90.0001tibia mineral mass (VT:1000283)compact volumetric bone mineral density (CMO:0001730)10538701450387014Rat
70223Bp57Blood pressure QTL 575arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)10180676123Rat
634329Pia15Pristane induced arthritis QTL 153.1joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)10124158324Rat
1578761Stresp21Stress response QTL 213.3thymus mass (VT:0004954)thymus wet weight (CMO:0000855)10637574651375746Rat
2293680Bss40Bone structure and strength QTL 405.660.0001femur strength trait (VT:0010010)femur total energy absorbed before break (CMO:0001677)10135225947Rat
7387235Uae41Urinary albumin excretion QTL 415.260.1874urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)10129497586Rat
2298544Neuinf9Neuroinflammation QTL 94.6nervous system integrity trait (VT:0010566)spinal cord complement component 1, q subcomponent, B chain mRNA level (CMO:0002126)10580199062146030Rat
10401803Kidm50Kidney mass QTL 50kidney mass (VT:0002707)both kidneys wet weight (CMO:0000085)1041834445418344Rat
737820Alc9Alcohol consumption QTL 92.2consumption behavior trait (VT:0002069)ethanol drink intake rate (CMO:0001407)10514402719233348Rat
2313081Bss64Bone structure and strength QTL 641.30.0001tibia strength trait (VT:1000284)tibia total energy absorbed before break (CMO:0001736)10538701450387014Rat
631828Alc5Alcohol consumption QTL 52.4consumption behavior trait (VT:0002069)ethanol drink intake rate (CMO:0001407)10514402717245662Rat
634327Hc4Hypercalciuria QTL 42.4urine calcium amount (VT:0002985)urine calcium excretion rate (CMO:0000763)10138328221Rat
2313095Bss62Bone structure and strength QTL 621.50.0001tibia size trait (VT:0100001)tibia midshaft cross-sectional area (CMO:0001717)10538701450387014Rat
631660Hcar1Hepatocarcinoma resistance QTL 13.40.0001liver integrity trait (VT:0010547)volume of individual liver tumorous lesion (CMO:0001078)10615418215990232Rat
1576304Schws7Schwannoma susceptibility QTL 70.0115nervous system integrity trait (VT:0010566)percentage of study population developing trigeminal nerve neurilemmomas during a period of time (CMO:0002017)10476552719816042Rat
7411611Foco17Food consumption QTL 1718.70.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)10142315980Rat
2303118Mamtr7Mammary tumor resistance QTL 70.003mammary gland integrity trait (VT:0010552)mammary tumor growth rate (CMO:0000344)109658275104670812Rat
9590268Scort13Serum corticosterone level QTL 133.260.001blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)101147401056474010Rat
2313104Bss61Bone structure and strength QTL 610.90.0001tibia area (VT:1000281)tibia midshaft cross-sectional area (CMO:0001717)10538701450387014Rat
61427Cia16Collagen induced arthritis QTL 163.2joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)10635789696121100Rat
9590310Scort19Serum corticosterone level QTL 196.30.001blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)101147401056474010Rat

Markers in Region
RH127604  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21069,702,700 - 69,702,904 (+)MAPPERmRatBN7.2
mRatBN7.21014,279,208 - 14,279,412 (-)MAPPERmRatBN7.2
mRatBN7.21014,279,208 - 14,279,412 (+)MAPPERmRatBN7.2
mRatBN7.21069,702,700 - 69,702,904 (-)MAPPERmRatBN7.2
Rnor_6.01072,148,529 - 72,148,732NCBIRnor6.0
Rnor_6.01014,620,070 - 14,620,273NCBIRnor6.0
Rnor_5.01014,437,660 - 14,437,863UniSTSRnor5.0
Rnor_5.01072,055,388 - 72,055,591UniSTSRnor5.0
RGSC_v3.41014,510,002 - 14,510,205UniSTSRGSC3.4
RGSC_v3.41073,106,012 - 73,106,215UniSTSRGSC3.4
Celera1068,630,602 - 68,630,805UniSTS
Celera1013,951,622 - 13,951,825UniSTS
Cytogenetic Map10q26UniSTS
Cytogenetic Map10q12UniSTS
BE107288  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21014,284,780 - 14,284,934 (+)MAPPERmRatBN7.2
Rnor_6.01014,625,642 - 14,625,795NCBIRnor6.0
Rnor_5.01014,443,232 - 14,443,385UniSTSRnor5.0
RGSC_v3.41014,515,574 - 14,515,727UniSTSRGSC3.4
Celera1013,957,194 - 13,957,347UniSTS
RH 3.4 Map10170.6UniSTS
Cytogenetic Map10q12UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
16 12 67 165 91 90 59 92 59 6 356 192 11 144 81 92 31 17 17

Sequence

Nucleotide Sequences
RefSeq Transcripts NM_001428972 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001428973 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001428974 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001428975 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001428976 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_013050 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006245918 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006245919 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006245920 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_008767549 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017597044 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063268474 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063268476 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063268477 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AC094421 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC086324 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC086592 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH473948 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ226760 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ228426 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ229169 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JAXUCZ010000010 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  U54632 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Ensembl Acc Id: ENSRNOT00000024406   ⟹   ENSRNOP00000024406
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1070,199,041 - 70,199,866 (+)Ensembl
mRatBN7.2 Ensembl1069,701,618 - 69,702,443 (+)Ensembl
Rnor_6.0 Ensembl1014,620,531 - 14,630,151 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000090085   ⟹   ENSRNOP00000075659
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1014,783,651 - 14,799,422 (-)Ensembl
mRatBN7.2 Ensembl1014,279,155 - 14,295,136 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000104064   ⟹   ENSRNOP00000085922
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1014,277,749 - 14,293,782 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000111980   ⟹   ENSRNOP00000091713
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1014,277,749 - 14,294,101 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000129620   ⟹   ENSRNOP00000108382
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1014,786,440 - 14,799,176 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000154507   ⟹   ENSRNOP00000101344
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1014,783,651 - 14,793,949 (-)Ensembl
RefSeq Acc Id: NM_013050   ⟹   NP_037182
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81014,783,651 - 14,798,254 (-)NCBI
mRatBN7.21014,279,155 - 14,293,759 (-)NCBI
Rnor_6.01014,620,016 - 14,634,619 (-)NCBI
Rnor_5.01014,436,200 - 14,456,889 (-)NCBI
RGSC_v3.41014,509,948 - 14,524,551 (-)RGD
Celera1013,951,568 - 13,966,171 (-)RGD
Sequence:
RefSeq Acc Id: XM_006245919   ⟹   XP_006245981
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81014,782,245 - 14,797,531 (-)NCBI
mRatBN7.21014,277,749 - 14,293,627 (-)NCBI
Rnor_6.01014,618,615 - 14,634,501 (-)NCBI
Rnor_5.01014,436,200 - 14,456,889 (-)NCBI
Sequence:
RefSeq Acc Id: XM_006245920   ⟹   XP_006245982
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81014,782,245 - 14,799,168 (-)NCBI
mRatBN7.21014,277,749 - 14,294,681 (-)NCBI
Rnor_6.01014,618,615 - 14,635,541 (-)NCBI
Rnor_5.01014,436,200 - 14,456,889 (-)NCBI
Sequence:
RefSeq Acc Id: XM_008767549   ⟹   XP_008765771
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81014,782,245 - 14,802,529 (-)NCBI
mRatBN7.21014,277,749 - 14,294,678 (-)NCBI
Rnor_6.01014,618,615 - 14,635,539 (-)NCBI
Sequence:
RefSeq Acc Id: XM_017597044   ⟹   XP_017452533
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81014,782,245 - 14,798,993 (-)NCBI
mRatBN7.21014,277,749 - 14,294,214 (-)NCBI
Rnor_6.01014,618,615 - 14,635,243 (-)NCBI
Sequence:
RefSeq Acc Id: XM_063268474   ⟹   XP_063124544
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81014,782,245 - 14,802,831 (-)NCBI
RefSeq Acc Id: XM_063268476   ⟹   XP_063124546
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81014,782,245 - 14,802,911 (-)NCBI
RefSeq Acc Id: XM_063268477   ⟹   XP_063124547
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81014,782,245 - 14,798,318 (-)NCBI
RefSeq Acc Id: NP_037182   ⟸   NM_013050
- UniProtKB: P63281 (UniProtKB/Swiss-Prot),   A6HD16 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006245982   ⟸   XM_006245920
- Peptide Label: isoform X4
- Sequence:
RefSeq Acc Id: XP_006245981   ⟸   XM_006245919
- Peptide Label: isoform X4
- Sequence:
RefSeq Acc Id: XP_008765771   ⟸   XM_008767549
- Peptide Label: isoform X1
- UniProtKB: A0A0G2KB55 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_017452533   ⟸   XM_017597044
- Peptide Label: isoform X4
- Sequence:
Ensembl Acc Id: ENSRNOP00000024406   ⟸   ENSRNOT00000024406
Ensembl Acc Id: ENSRNOP00000091713   ⟸   ENSRNOT00000111980
Ensembl Acc Id: ENSRNOP00000085922   ⟸   ENSRNOT00000104064
Ensembl Acc Id: ENSRNOP00000075659   ⟸   ENSRNOT00000090085
RefSeq Acc Id: XP_063124546   ⟸   XM_063268476
- Peptide Label: isoform X3
RefSeq Acc Id: XP_063124544   ⟸   XM_063268474
- Peptide Label: isoform X2
RefSeq Acc Id: XP_063124547   ⟸   XM_063268477
- Peptide Label: isoform X5
Ensembl Acc Id: ENSRNOP00000108382   ⟸   ENSRNOT00000129620
Ensembl Acc Id: ENSRNOP00000101344   ⟸   ENSRNOT00000154507
Protein Domains
UBC core

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P63281-F1-model_v2 AlphaFold P63281 1-158 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:3926 AgrOrtholog
BioCyc Gene G2FUF-25792 BioCyc
Ensembl Genes ENSRNOG00000017907 Ensembl
  ENSRNOG00000066579 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000090085 ENTREZGENE
  ENSRNOT00000104064.1 UniProtKB/Swiss-Prot
  ENSRNOT00000154507 ENTREZGENE
Gene3D-CATH 3.10.110.10 UniProtKB/Swiss-Prot
IMAGE_CLONE IMAGE:7305067 IMAGE-MGC_LOAD
  IMAGE:7310403 IMAGE-MGC_LOAD
InterPro Ub_conjugating_enzyme UniProtKB/Swiss-Prot
  UBQ-conjugat_E2 UniProtKB/Swiss-Prot
  UBQ-conjugating_AS UniProtKB/Swiss-Prot
  UBQ-conjugating_enzyme/RWD UniProtKB/Swiss-Prot
KEGG Report rno:25573 UniProtKB/Swiss-Prot
MGC_CLONE MGC:105476 IMAGE-MGC_LOAD
  MGC:105477 IMAGE-MGC_LOAD
NCBI Gene 25573 ENTREZGENE
PANTHER UBIQUITIN-CONJUGATING ENZYME E2 UniProtKB/Swiss-Prot
Pfam UQ_con UniProtKB/Swiss-Prot
PhenoGen Ube2i PhenoGen
PROSITE UBIQUITIN_CONJUGAT_1 UniProtKB/Swiss-Prot
  UBIQUITIN_CONJUGAT_2 UniProtKB/Swiss-Prot
RatGTEx ENSRNOG00000017907 RatGTEx
  ENSRNOG00000066579 RatGTEx
SMART UBCc UniProtKB/Swiss-Prot
Superfamily-SCOP SSF54495 UniProtKB/Swiss-Prot
TIGR TC228339
UniProt A0A0G2KB55 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I6AG56_RAT UniProtKB/TrEMBL
  A0A8L2QCN1_RAT UniProtKB/TrEMBL
  A6HD16 ENTREZGENE, UniProtKB/TrEMBL
  P63281 ENTREZGENE, UniProtKB/Swiss-Prot
UniProt Secondary P50550 UniProtKB/Swiss-Prot
  Q15698 UniProtKB/Swiss-Prot
  Q86VB3 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2011-08-01 Ube2i  ubiquitin-conjugating enzyme E2I  Ube2i  ubiquitin-conjugating enzyme E2I (UBC9 homolog, yeast)  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2010-05-25 Ube2i  ubiquitin-conjugating enzyme E2I (UBC9 homolog, yeast)  Ube2i  ubiquitin-conjugating enzyme E2I  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2002-06-10 Ube2i  Ubiquitin conjugating enzyme E2I      Symbol and Name status set to approved 70586 APPROVED

RGD Curation Notes
Note Type Note Reference
gene_physical_interaction protein binds helix-loop-helix protein E47 specificaly at a 54 aa region (477-530) 730030