Clu (clusterin) - Rat Genome Database

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Gene: Clu (clusterin) Rattus norvegicus
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Symbol: Clu
Name: clusterin
RGD ID: 3907
Description: Predicted to enable several functions, including amyloid-beta binding activity; misfolded protein binding activity; and signaling receptor binding activity. Involved in several processes, including estrous cycle; protein stabilization; and response to potassium ion. Located in several cellular components, including aggresome; growth cone; and perinuclear region of cytoplasm. Used to study atherosclerosis and renal fibrosis. Biomarker of several diseases, including anti-basement membrane glomerulonephritis; brain ischemia; kidney failure (multiple); prostate disease (multiple); and pulmonary hypertension. Human ortholog(s) of this gene implicated in artery disease (multiple); breast cancer; diabetic retinopathy; exfoliation syndrome; and muscular disease (multiple). Orthologous to human CLU (clusterin); INTERACTS WITH (S)-colchicine; 1,1,1-Trichloro-2-(o-chlorophenyl)-2-(p-chlorophenyl)ethane; 1,2-dimethylhydrazine.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: APOJ; CLI; DAG; dimeric acid glycoprotein; RATTRPM2B; SGP-2; SGP2; SP-40; SP40; sulfated glycoprotein 2; testosterone repressed prostate message 2; testosterone-repressed prostate message; testostrone-repressed prostate message 2; TRPM-2; Trpm2; TRPM2B; Trpmb
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81544,336,619 - 44,375,861 (+)NCBIGRCr8
mRatBN7.21540,161,068 - 40,200,315 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1540,174,617 - 40,200,315 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1542,026,339 - 42,065,337 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01543,176,537 - 43,215,535 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01541,621,373 - 41,660,612 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01542,626,612 - 42,665,858 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1542,640,146 - 42,665,857 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01548,926,511 - 48,965,757 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41545,365,779 - 45,405,314 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11545,381,558 - 45,421,094 (+)NCBI
Celera1539,832,711 - 39,871,901 (+)NCBICelera
Cytogenetic Map15p12NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View
acute kidney failure  (IEP,ISO)
Alzheimer's disease  (ISO)
amyotrophic lateral sclerosis type 1  (ISO)
anti-basement membrane glomerulonephritis  (IEP)
atherosclerosis  (IDA)
Atrophy  (ISO)
autosomal dominant nocturnal frontal lobe epilepsy  (ISO)
benign familial infantile seizures 6  (ISO)
brain ischemia  (IEP)
breast cancer  (ISO)
Breast Neoplasms  (ISO)
Chemical and Drug Induced Liver Injury  (ISO)
Chronic Allograft Nephropathy  (IEP)
chronic kidney disease  (IEP)
cicatricial pemphigoid  (ISO)
Cognitive Dysfunction  (ISO)
conjunctival disease  (ISO)
coronary artery disease  (ISO)
Diabetic Nephropathies  (IEP)
diabetic retinopathy  (ISO)
Drug-Related Side Effects and Adverse Reactions  (ISO)
exfoliation syndrome  (ISO)
Experimental Diabetes Mellitus  (IEP)
Experimental Mammary Neoplasms  (ISO)
Fuchs' endothelial dystrophy  (ISO)
gelatinous drop-like corneal dystrophy  (ISO)
Hyperplasia  (ISO)
hypertension  (ISO)
inclusion body myositis  (ISO)
invasive ductal carcinoma  (ISO)
iron metabolism disease  (ISO)
juvenile rheumatoid arthritis  (ISO)
Kawasaki disease  (ISO)
kidney disease  (ISO)
lupus nephritis  (ISO)
Lymphatic Metastasis  (ISO)
macular retinal edema  (ISO)
melanoma  (ISO)
muscular disease  (ISO)
mycosis fungoides  (ISO)
myocardial infarction  (ISO)
nasal cavity adenocarcinoma  (ISO)
Neointima  (ISO)
Neoplasm Metastasis  (ISO)
Neovascularization, Pathologic  (ISO)
Optic Nerve Injuries  (IEP)
osteoarthritis  (ISO)
Pituitary Neoplasms  (ISO)
pre-eclampsia  (ISO)
prostate adenocarcinoma  (IEP)
prostatic hypertrophy  (IEP)
Prostatic Neoplasms  (ISO)
proteinuria  (IEP)
psoriasis  (ISO)
pulmonary hypertension  (IEP)
renal fibrosis  (IMP)
Retina Reperfusion Injury  (IEP)
retinal degeneration  (IEP)
skin papilloma  (ISO)
squamous cell carcinoma  (ISO)
Stevens-Johnson syndrome  (ISO)
systemic lupus erythematosus  (ISO)
systemic scleroderma  (ISO)
vitiligo  (ISO)

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(S)-colchicine  (EXP)
(S)-ropivacaine  (ISO)
1,1'-azobis(N,N-dimethylformamide)  (ISO)
1,1,1-trichloro-2,2-bis(4-hydroxyphenyl)ethane  (ISO)
1,1,1-Trichloro-2-(o-chlorophenyl)-2-(p-chlorophenyl)ethane  (EXP)
1,2-dimethylhydrazine  (EXP,ISO)
1-naphthyl isothiocyanate  (EXP)
1-nitropyrene  (ISO)
17alpha-ethynylestradiol  (EXP)
17beta-estradiol  (EXP,ISO)
17beta-estradiol 3-benzoate  (EXP)
17beta-hydroxy-17-methylestra-4,9,11-trien-3-one  (ISO)
17beta-hydroxy-5alpha-androstan-3-one  (ISO)
2,2',4,4'-Tetrabromodiphenyl ether  (ISO)
2,2,2-tetramine  (EXP)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,3-dimethoxynaphthalene-1,4-dione  (ISO)
2,4-dibromophenyl 2,4,5-tribromophenyl ether  (ISO)
2,5-hexanedione  (EXP)
2-(3,4-dimethoxyphenyl)-5-\{[2-(3,4-dimethoxyphenyl)ethyl](methyl)amino\}-2-(propan-2-yl)pentanenitrile  (ISO)
2-acetamidofluorene  (EXP)
2-hydroxypropanoic acid  (ISO)
2-methoxyethanol  (EXP)
3,3',4,4',5-pentachlorobiphenyl  (EXP)
3,3',4,4'-tetrachlorobiphenyl  (ISO)
3,3',5-triiodo-L-thyronine  (EXP)
3-chloropropane-1,2-diol  (ISO)
4,4'-diaminodiphenylmethane  (EXP)
4,4'-Dichlorobenzophenone  (ISO)
4,4'-sulfonyldiphenol  (EXP,ISO)
4-tert-Octylphenol  (EXP)
5-aza-2'-deoxycytidine  (ISO)
6-propyl-2-thiouracil  (EXP)
acrylamide  (ISO)
aflatoxin B1  (EXP,ISO)
Aflatoxin B2 alpha  (ISO)
all-trans-retinoic acid  (ISO)
allethrin  (EXP)
aluminium oxide  (ISO)
ammonia  (EXP)
ammonium chloride  (EXP,ISO)
amphotericin B  (EXP,ISO)
antirheumatic drug  (ISO)
arsenous acid  (ISO)
atrazine  (EXP)
azoxystrobin  (EXP)
bacitracin  (EXP)
bathocuproine disulfonic acid  (ISO)
belinostat  (ISO)
benzene  (ISO)
benzo[a]pyrene  (ISO)
benzo[a]pyrene diol epoxide I  (ISO)
bicalutamide  (ISO)
bis(2-ethylhexyl) phthalate  (EXP)
bisphenol A  (EXP,ISO)
bisphenol F  (EXP,ISO)
bortezomib  (ISO)
cadmium atom  (EXP,ISO)
cadmium dichloride  (EXP,ISO)
calcitriol  (ISO)
carbendazim  (EXP)
carbon nanotube  (ISO)
carboplatin  (EXP)
carnosic acid  (ISO)
CGP 52608  (ISO)
chlordecone  (ISO)
chloroform  (EXP)
chloroquine  (EXP)
chlorpyrifos  (EXP)
cisplatin  (EXP,ISO)
clofibrate  (ISO)
cobalt dichloride  (ISO)
copper atom  (EXP,ISO)
copper(0)  (EXP,ISO)
copper(II) chloride  (ISO)
copper(II) sulfate  (ISO)
coumestrol  (ISO)
crocidolite asbestos  (ISO)
CU-O LINKAGE  (ISO)
cumene  (ISO)
Cuprizon  (EXP)
cyanuric acid  (EXP)
cyclosporin A  (EXP,ISO)
cyhalothrin  (EXP)
cypermethrin  (EXP)
D-penicillamine  (ISO)
dacarbazine  (ISO)
daidzein  (EXP)
DDE  (EXP,ISO)
DDT  (EXP)
deferasirox  (EXP)
depsipeptide  (ISO)
dexamethasone  (EXP,ISO)
diallyl trisulfide  (ISO)
diarsenic trioxide  (ISO)
dibenzoylmethane  (ISO)
dibutyl phthalate  (EXP)
dichlorine  (EXP,ISO)
diclofenac  (EXP,ISO)
diethylstilbestrol  (EXP,ISO)
dimethylarsinic acid  (ISO)
dimethylarsinous acid  (ISO)
dioxygen  (ISO)
dobutamine  (ISO)
dorsomorphin  (ISO)
doxorubicin  (EXP,ISO)
elemental selenium  (ISO)
enalapril  (EXP)
Enterolactone  (ISO)
entinostat  (ISO)
ethanol  (ISO)
fenvalerate  (EXP)
flutamide  (EXP)
folic acid  (EXP,ISO)
formaldehyde  (ISO)
fulvestrant  (EXP,ISO)
fumonisin B1  (ISO)
furan  (EXP)
gamma-hexachlorocyclohexane  (EXP)
gemcitabine  (ISO)
genistein  (EXP,ISO)
gentamycin  (EXP)
glutathione  (EXP)
glycidol  (ISO)
glyphosate  (EXP,ISO)
graphite  (EXP)
Hexachloro-1,3-butadiene  (EXP)
hydrogen peroxide  (ISO)
ibuprofen  (ISO)
imidacloprid  (EXP)
iron dichloride  (ISO)
isocyanuric acid  (EXP)
isoflavones  (EXP)
isoprenaline  (ISO)
kainic acid  (EXP)
ketamine  (EXP)
ketoconazole  (EXP)
kojic acid  (EXP)
L-ascorbic acid  (EXP)
L-glutamic acid  (EXP)
lead(0)  (ISO)
levamisole  (ISO)
Licochalcone B  (ISO)
linsidomine  (EXP)
lipopolysaccharide  (ISO)
m-xylene  (EXP)
maneb  (ISO)
Meclizine  (ISO)
megestrol  (ISO)
melamine  (EXP)
mercury dichloride  (EXP)
metaproterenol  (ISO)
Methazolamide  (ISO)
methimazole  (EXP)
methoxyacetic acid  (EXP,ISO)
methoxychlor  (EXP,ISO)
methylarsonic acid  (ISO)
methylisothiazolinone  (ISO)
methylseleninic acid  (ISO)
mitoxantrone  (ISO)
N-(3-methyl-5-sulfamoyl-1,3,4-thiadiazol-2-ylidene)acetamide  (ISO)
N-acetyl-L-cysteine  (ISO)
N-methyl-N-nitrosourea  (EXP)
N-nitrosodiethylamine  (EXP)
naphthalene  (ISO)
natamycin  (ISO)
nickel atom  (ISO)
nifedipine  (EXP)
nimodipine  (ISO)
nitroglycerin  (EXP)
Nonylphenol  (EXP)
nystatin  (ISO)
ochratoxin A  (EXP)
okadaic acid  (ISO)
olanzapine  (ISO)
omega-conotoxin GVIA  (EXP)
orciprenaline  (ISO)
oxaliplatin  (EXP)
ozone  (EXP,ISO)
p-chloromercuribenzoic acid  (ISO)
p-menthan-3-ol  (ISO)
p-tert-Amylphenol  (EXP)
paclitaxel  (ISO)
panobinostat  (ISO)
paracetamol  (EXP,ISO)
paraquat  (ISO)
patulin  (EXP)
perfluorohexanesulfonic acid  (ISO)
perfluorooctane-1-sulfonic acid  (EXP)
perfluorooctanoic acid  (ISO)
phenethyl isothiocyanate  (ISO)
phenobarbital  (EXP)
phenylephrine  (EXP)
phenylmercury acetate  (ISO)
pirinixic acid  (ISO)
potassium bromate  (EXP)
potassium chromate  (ISO)
potassium dichromate  (ISO)
pregnenolone 16alpha-carbonitrile  (EXP,ISO)
procymidone  (EXP)
progesterone  (EXP)
rac-lactic acid  (ISO)
raloxifene  (ISO)
razoxane  (ISO)
resveratrol  (ISO)
rofecoxib  (ISO)
rotenone  (ISO)
sarin  (ISO)
SB 431542  (ISO)
selenium atom  (ISO)
silicon dioxide  (ISO)
silver atom  (ISO)
silver(0)  (ISO)
sodium arsenate  (ISO)
sodium arsenite  (ISO)
sodium fluoride  (EXP)
streptozocin  (EXP)
styrene  (EXP)
succimer  (ISO)
sulfadimethoxine  (EXP)
sulfasalazine  (ISO)
sulforaphane  (ISO)
sulindac  (ISO)
sunitinib  (ISO)
T-2 toxin  (ISO)
tacrolimus hydrate  (EXP)
tamoxifen  (ISO)
Tanshinone I  (ISO)
tert-butyl hydroperoxide  (ISO)
testosterone  (EXP,ISO)
Testosterone propionate  (EXP)
tetrachloromethane  (EXP,ISO)
tetracycline  (EXP)
tetramethylpyrazine  (EXP)
theophylline  (EXP)
thiabendazole  (EXP)
thimerosal  (ISO)
thiram  (ISO)
titanium dioxide  (ISO)
topotecan  (EXP)
triazines  (ISO)
trichloroethene  (EXP)
trichostatin A  (ISO)
triphenyl phosphate  (ISO)
Triptolide  (EXP)
tris(2-butoxyethyl) phosphate  (ISO)
troglitazone  (EXP)
valproic acid  (ISO)
vanadium atom  (ISO)
vanadium(0)  (ISO)
vancomycin  (EXP,ISO)
verapamil  (ISO)
vinclozolin  (EXP)
vitamin E  (EXP,ISO)
wortmannin  (ISO)
zinc atom  (ISO)
zinc(0)  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
amyloid-beta clearance  (IEA,ISO)
cell morphogenesis  (IEA,ISO,ISS)
cellular response to growth factor stimulus  (IEP)
central nervous system myelin maintenance  (IEA,ISO,ISS)
chaperone-mediated protein complex assembly  (IEA,ISO,ISS)
chaperone-mediated protein folding  (IEA,ISO,ISS)
endocrine pancreas development  (IMP)
estrous cycle  (IEP)
immune complex clearance  (IEA,ISO,ISS)
intrinsic apoptotic signaling pathway  (ISO,ISS)
microglial cell activation  (IEA,ISO,ISS)
microglial cell proliferation  (IEA,ISO,ISS)
negative regulation of amyloid fibril formation  (IEA,ISO,ISS)
negative regulation of amyloid-beta formation  (IEA,ISO,ISS)
negative regulation of apoptotic process  (IMP)
negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage  (IEA,ISO,ISS)
negative regulation of neuron apoptotic process  (IGI)
negative regulation of protein-containing complex assembly  (IEA,ISO,ISS)
negative regulation of response to endoplasmic reticulum stress  (IEA,ISO)
neuron projection morphogenesis  (IMP)
positive regulation of amyloid-beta formation  (IEA,ISO,ISS)
positive regulation of apoptotic process  (IEA,ISO,ISS)
positive regulation of cell differentiation  (IMP)
positive regulation of cell population proliferation  (IMP)
positive regulation of gene expression  (IGI)
positive regulation of intrinsic apoptotic signaling pathway  (ISO,ISS)
positive regulation of neurofibrillary tangle assembly  (IEA,ISO,ISS)
positive regulation of NF-kappaB transcription factor activity  (IEA,ISO,ISS)
positive regulation of nitric oxide biosynthetic process  (IEA,ISO,ISS)
positive regulation of proteasomal ubiquitin-dependent protein catabolic process  (IBA,IEA,ISO,ISS)
positive regulation of protein-containing complex assembly  (IEA,ISO)
positive regulation of receptor-mediated endocytosis  (IEA,ISO,ISS)
positive regulation of tumor necrosis factor production  (IEA,ISO,ISS)
positive regulation of ubiquitin-dependent protein catabolic process  (ISO,ISS)
protein import  (IEA,ISO,ISS)
protein stabilization  (IDA,IEA,ISO,ISS)
protein targeting to lysosome involved in chaperone-mediated autophagy  (IEA,ISO)
regulation of amyloid-beta clearance  (IEA,ISO,ISS)
regulation of apoptotic process  (IBA)
regulation of cell population proliferation  (IEA,ISO,ISS)
regulation of neuronal signal transduction  (IEA,ISO,ISS)
response to light stimulus  (IEP)
response to misfolded protein  (IEA,ISO,ISS)
response to potassium ion  (IEP)
response to virus  (IEA,ISO)
signal transduction  (IEA)
spermatogenesis  (IEA)

Cellular Component

References

References - curated
# Reference Title Reference Citation
1. Clusterin, a binding protein with a molten globule-like region. Bailey RW, etal., Biochemistry. 2001 Oct 2;40(39):11828-40.
2. Identification of an androgen-repressed mRNA in rat ventral prostate as coding for sulphated glycoprotein 2 by cDNA cloning and sequence analysis. Bettuzzi S, etal., Biochem J 1989 Jan 1;257(1):293-6.
3. Genetic analysis of the clusterin gene in pseudoexfoliation syndrome. Burdon KP, etal., Mol Vis. 2008 Sep 22;14:1727-36.
4. Iron deficiency alters expression of genes implicated in Alzheimer disease pathogenesis. Carlson ES, etal., Brain Res. 2008 Aug 7.
5. Association of apolipoprotein J gene 866C-->T polymorphism with preeclampsia and essential hypertension. Chen M, etal., Gynecol Obstet Invest. 2005;60(3):133-8. Epub 2005 May 27.
6. Clusterin and FOXL2 act concordantly to regulate pituitary gonadotroph adenoma growth. Chesnokova V, etal., Mol Endocrinol. 2012 Dec;26(12):2092-103. doi: 10.1210/me.2012-1158. Epub 2012 Oct 9.
7. Biosynthesis and molecular cloning of sulfated glycoprotein 2 secreted by rat Sertoli cells. Collard MW and Griswold MD, Biochemistry 1987 Jun 16;26(12):3297-303.
8. Intracellular clusterin causes juxtanuclear aggregate formation and mitochondrial alteration. Debure L, etal., J Cell Sci. 2003 Aug 1;116(Pt 15):3109-21. Epub 2003 Jun 10.
9. Involvement of clusterin and the aggresome in abnormal protein deposits in myofibrillar myopathies and inclusion body myositis. Ferrer I, etal., Brain Pathol. 2005 Apr;15(2):101-8.
10. Human clusterin (CLI) maps to 8p21 in proximity to the lipoprotein lipase (LPL) gene. Fink TM, etal., Genomics 1993 May;16(2):526-8.
11. Effects of clusterin over-expression on metastatic progression and therapy in breast cancer. Flanagan L, etal., BMC Cancer. 2010 Mar 22;10:107. doi: 10.1186/1471-2407-10-107.
12. Mesenchymal stem cell therapy prevents interstitial fibrosis and tubular atrophy in a rat kidney allograft model. Franquesa M, etal., Stem Cells Dev. 2012 Nov 20;21(17):3125-35. doi: 10.1089/scd.2012.0096. Epub 2012 May 18.
13. Decreased plasma levels of clusterin in patients with psoriasis. Garcia-Rodriguez S, etal., Actas Dermosifiliogr. 2013 Jul-Aug;104(6):497-503. doi: 10.1016/j.ad.2012.11.019. Epub 2013 Mar 21.
14. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
15. Possible neuroprotective role of clusterin in Alzheimer's disease: a quantitative immunocytochemical study. Giannakopoulos P, etal., Acta Neuropathol. 1998 Apr;95(4):387-94.
16. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
17. Expression of clusterin in Muller cells of the rat retina after pressure-induced ischemia. Gwon JS, etal., Glia. 2004 Jul;47(1):35-45.
18. Identification of new pathogenic candidates for diabetic macular edema using fluorescence-based difference gel electrophoresis analysis. Hernandez C, etal., Diabetes Metab Res Rev. 2013 Sep;29(6):499-506. doi: 10.1002/dmrr.2419.
19. Normal gene expression in male F344 rat nasal transitional and respiratory epithelium. Hester SD, etal., Gene 2002 Feb 20;285(1-2):301-10.
20. Urinary clusterin levels in the rat correlate with the severity of tubular damage and may help to differentiate between glomerular and tubular injuries. Hidaka S, etal., Cell Tissue Res. 2002 Dec;310(3):289-96. Epub 2002 Oct 2.
21. Identification of a transcript predicting an alternative form of sulfated glycoprotein-2 (clusterin) in rat tissues. Izawa M Biochem Mol Biol Int 1998 Jan;44(1):9-18.
22. Clusterin attenuates the development of renal fibrosis. Jung GS, etal., J Am Soc Nephrol. 2012 Jan;23(1):73-85. doi: 10.1681/ASN.2011010048. Epub 2011 Nov 3.
23. Increased clusterin expression in Fuchs' endothelial dystrophy. Jurkunas UV, etal., Invest Ophthalmol Vis Sci. 2008 Jul;49(7):2946-55. doi: 10.1167/iovs.07-1405. Epub 2008 Mar 31.
24. Up-regulation of clusterin during phthalocyanine 4 photodynamic therapy-mediated apoptosis of tumor cells and ablation of mouse skin tumors. Kalka K, etal., Cancer Res. 2000 Nov 1;60(21):5984-7.
25. Clusterin interacts with SCLIP (SCG10-like protein) and promotes neurite outgrowth of PC12 cells. Kang SW, etal., Exp Cell Res. 2005 Oct 1;309(2):305-15.
26. The role of clusterin on pancreatic beta cell regeneration after exendin-4 treatment in neonatal streptozotocin administrated rats. Kaya-Dagistanli F and Ozturk M, Acta Histochem. 2013 Jul;115(6):577-86. doi: 10.1016/j.acthis.2012.12.007. Epub 2013 Jan 23.
27. Clusterin regulates ß-amyloid toxicity via Dickkopf-1-driven induction of the wnt-PCP-JNK pathway. Killick R, etal., Mol Psychiatry. 2014 Jan;19(1):88-98. doi: 10.1038/mp.2012.163. Epub 2012 Nov 20.
28. Clusterin induces differentiation of pancreatic duct cells into insulin-secreting cells. Kim BM, etal., Diabetologia. 2006 Feb;49(2):311-20. Epub 2006 Jan 13.
29. Protective role of clusterin/apolipoprotein J against neointimal hyperplasia via antiproliferative effect on vascular smooth muscle cells and cytoprotective effect on endothelial cells. Kim HJ, etal., Arterioscler Thromb Vasc Biol. 2009 Oct;29(10):1558-64. doi: 10.1161/ATVBAHA.109.190058. Epub 2009 Aug 20.
30. A signaling network in phenylephrine-induced benign prostatic hyperplasia. Kim J, etal., Endocrinology. 2009 Aug;150(8):3576-83. doi: 10.1210/en.2008-1782. Epub 2009 May 14.
31. Protective effect of clusterin on blood-retinal barrier breakdown in diabetic retinopathy. Kim JH, etal., Invest Ophthalmol Vis Sci. 2010 Mar;51(3):1659-65. doi: 10.1167/iovs.09-3615. Epub 2009 Oct 29.
32. Nuclear clusterin is associated with neuronal apoptosis in the developing rat brain upon ethanol exposure. Kim N, etal., Alcohol Clin Exp Res. 2012 Jan;36(1):72-82. doi: 10.1111/j.1530-0277.2011.01588.x. Epub 2011 Jul 18.
33. Retinal expression of clusterin in the streptozotocin-induced diabetic rat. Kim YS, etal., Brain Res. 2003 Jun 20;976(1):53-9.
34. Hydrogen peroxide and ADP-ribose induce TRPM2-mediated calcium influx and cation currents in microglia. Kraft R, etal., Am J Physiol Cell Physiol. 2004 Jan;286(1):C129-37. Epub 2003 Sep 24.
35. Prognostic significance of clusterin immunoreactivity in breast cancer. Kruger S, etal., Neoplasma. 2007;54(1):46-50.
36. Exploring functional candidate genes for genetic association in german patients with pseudoexfoliation syndrome and pseudoexfoliation glaucoma. Krumbiegel M, etal., Invest Ophthalmol Vis Sci. 2009 Jun;50(6):2796-801. doi: 10.1167/iovs.08-2339. Epub 2009 Jan 31.
37. Differential proteomics in the aging Noble rat ventral prostate. Lam YW, etal., Proteomics. 2008 Jul;8(13):2750-63. doi: 10.1002/pmic.200700986.
38. Clusterin regulates transthyretin amyloidosis. Lee KW, etal., Biochem Biophys Res Commun. 2009 Oct 16;388(2):256-60. doi: 10.1016/j.bbrc.2009.07.166. Epub 2009 Aug 5.
39. Stable knockdown of clusterin by vectorbased RNA interference in a human breast cancer cell line inhibits tumour cell invasion and metastasis. Li J, etal., J Int Med Res. 2012;40(2):545-55.
40. Secretory clusterin is upregulated in rats with pulmonary arterial hypertension induced by systemic-to-pulmonary shunts and exerts important roles in pulmonary artery smooth muscle cells. Liu X, etal., Acta Physiol (Oxf). 2014 Jul 29. doi: 10.1111/apha.12352.
41. Endothelial Cdkn1a (p21) overexpression and accelerated senescence in a mouse model of Fuchs endothelial corneal dystrophy. Matthaei M, etal., Invest Ophthalmol Vis Sci. 2012 Sep 28;53(10):6718-27.
42. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
43. Tubular up-regulation of clusterin mRNA in murine lupus-like nephritis. Moll S, etal., Am J Pathol. 1998 Apr;152(4):953-62.
44. Changes in conjunctival clusterin expression in severe ocular surface disease. Nakamura T, etal., Invest Ophthalmol Vis Sci. 2002 Jun;43(6):1702-7.
45. [Molecular mechanism of pathological keratinization in severe ocular surface diseases]. Nakamura T, Nippon Ganka Gakkai Zasshi. 2004 Nov;108(11):654-64.
46. An oral apoJ peptide renders HDL antiinflammatory in mice and monkeys and dramatically reduces atherosclerosis in apolipoprotein E-null mice. Navab M, etal., Arterioscler Thromb Vasc Biol. 2005 Sep;25(9):1932-7. Epub 2005 Jun 16.
47. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
48. Systemic lupus erythematosus, a disease associated with low levels of clusterin/apoJ, an antiinflammatory protein. Newkirk MM, etal., J Rheumatol. 1999 Mar;26(3):597-603.
49. Apolipoproteins J and E co-localise with amyloid in gelatinous drop-like and lattice type I corneal dystrophies. Nishida K, etal., Br J Ophthalmol. 1999 Oct;83(10):1178-82.
50. Small interfering RNA targeted to secretory clusterin blocks tumor growth, motility, and invasion in breast cancer. Niu Z, etal., Acta Biochim Biophys Sin (Shanghai). 2012 Dec;44(12):991-8. doi: 10.1093/abbs/gms091. Epub 2012 Oct 25.
51. Complement activation following optic nerve crush in the adult rat. Ohlsson M, etal., J Neurotrauma. 2003 Sep;20(9):895-904.
52. Modulation of clusterin isoforms is associated with all-trans retinoic acid-induced proliferative arrest and apoptosis of intimal smooth muscle cells. Orlandi A, etal., Arterioscler Thromb Vasc Biol. 2005 Feb;25(2):348-53. Epub 2004 Dec 9.
53. Plasma clusterin concentrations may predict resistance to intravenous immunoglobulin in patients with Kawasaki disease. Ou-Yang MC, etal., ScientificWorldJournal. 2013 Jul 15;2013:382523. doi: 10.1155/2013/382523. eCollection 2013.
54. Role of an extracellular chaperone, Clusterin in the pathogenesis of Pseudoexfoliation Syndrome and Pseudoexfoliation Glaucoma. Padhy B, etal., Exp Eye Res. 2014 Jul 21;127C:69-76. doi: 10.1016/j.exer.2014.07.005.
55. Citicoline reduces upregulated clusterin following kainic acid injection in the rat retina. Park CH, etal., Curr Eye Res. 2007 Dec;32(12):1055-63.
56. Overexpression of clusterin in human breast carcinoma. Redondo M, etal., Am J Pathol. 2000 Aug;157(2):393-9.
57. An integrated rat genetic map: analysis of linkage conservation with the mouse and human maps. Remmers EF, etal., Transplant Proc 1999 May;31(3):1549-54.
58. GOA pipeline RGD automated data pipeline
59. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
60. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
61. Estrous cycle regulation of mammary epithelial cell proliferation, differentiation, and death in the Sprague-Dawley rat: a model for investigating the role of estrous cycling in mammary carcinogenesis. Schedin P, etal., J Mammary Gland Biol Neoplasia. 2000 Apr;5(2):211-25.
62. Prognostic impact of polymorphisms in the MYBL2 interacting genes in breast cancer. Shi H, etal., Breast Cancer Res Treat. 2012 Feb;131(3):1039-47. doi: 10.1007/s10549-011-1826-2. Epub 2011 Oct 26.
63. Deficiency of clusterin inhibits neointimal hyperplasia after vascular injury. Shirasawa T, etal., J Atheroscler Thromb. 2009;16(6):772-81. Epub 2009 Dec 22.
64. Photoreceptor cells in the vitiligo mouse die by apoptosis. TRPM-2/clusterin expression is increased in the neural retina and in the retinal pigment epithelium. Smith SB, etal., Invest Ophthalmol Vis Sci. 1995 Oct;36(11):2193-201.
65. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, etal., Proc Natl Acad Sci U S A. 2002 Dec 24;99(26):16899-903. Epub 2002 Dec 11.
66. Apocynin, an NADPH oxidase inhibitor, suppresses rat prostate carcinogenesis. Suzuki S, etal., Cancer Sci. 2013 Dec;104(12):1711-7. doi: 10.1111/cas.12292. Epub 2013 Oct 28.
67. NF-kappaB-dependent genes induced by proteinuria and identified using DNA microarrays. Takase O, etal., Clin Exp Nephrol. 2008 Jun;12(3):181-8. doi: 10.1007/s10157-008-0038-5. Epub 2008 Feb 15.
68. Myc-transformed epithelial cells down-regulate clusterin, which inhibits their growth in vitro and carcinogenesis in vivo. Thomas-Tikhonenko A, etal., Cancer Res. 2004 May 1;64(9):3126-36.
69. Prognostic factors in 105 Japanese cases of mycosis fungoides and Sezary syndrome: clusterin expression as a novel prognostic factor. Tobisawa S, etal., J Dermatol Sci. 2013 Sep;71(3):160-6. doi: 10.1016/j.jdermsci.2013.04.020. Epub 2013 May 2.
70. Urinary cystatin C as a renal biomarker and its immunohistochemical localization in anti-GBM glomerulonephritis rats. Togashi Y, etal., Exp Toxicol Pathol. 2013 Nov;65(7-8):1137-43. doi: 10.1016/j.etp.2013.05.005. Epub 2013 Jun 21.
71. Gene expression profiling in sinonasal adenocarcinoma. Tripodi D, etal., BMC Med Genomics. 2009 Nov 10;2:65. doi: 10.1186/1755-8794-2-65.
72. The effects of ACE inhibitor and angiotensin receptor blocker on clusterin and apoptosis in the kidney tissue of streptozotocin-diabetic rats. Tuncdemir M and Ozturk M, J Mol Histol. 2008 Dec;39(6):605-16. doi: 10.1007/s10735-008-9201-2. Epub 2008 Oct 24.
73. Intravenous clusterin administration reduces myocardial infarct size in rats. Van Dijk A, etal., Eur J Clin Invest. 2010 Oct;40(10):893-902. doi: 10.1111/j.1365-2362.2010.02345.x.
74. Tissue Kim-1 and urinary clusterin as early indicators of cisplatin-induced acute kidney injury in rats. Vinken P, etal., Toxicol Pathol. 2012 Oct;40(7):1049-62. Epub 2012 May 11.
75. Delayed, but prolonged increases in astrocytic clusterin (ApoJ) mRNA expression following acute cortical spreading depression in the rat: evidence for a role of clusterin in ischemic tolerance. Wiggins AK, etal., Brain Res Mol Brain Res 2003 May 26;114(1):20-30.
76. Expression of multiple forms of clusterin during light-induced retinal degeneration. Wong P, etal., Curr Eye Res. 2001 Sep;23(3):157-65.
77. Genomic organization and expression of the rat TRPM-2 (clusterin) gene, a gene implicated in apoptosis. Wong P, etal., J Biol Chem 1993 Mar 5;268(7):5021-31.
78. A possible contribution of elevated serum clusterin levels to the inhibition of digital ulcers and pulmonary arterial hypertension in systemic sclerosis. Yanaba K, etal., Arch Dermatol Res. 2012 Aug;304(6):459-63. doi: 10.1007/s00403-012-1219-3. Epub 2012 Feb 17.
79. Plasma clusterin levels in predicting the occurrence of coronary artery lesions in patients with Kawasaki disease. Yu HR, etal., Pediatr Cardiol. 2010 Nov;31(8):1151-6. doi: 10.1007/s00246-010-9769-7. Epub 2010 Aug 15.
80. Clusterin deficiency in eyes with pseudoexfoliation syndrome may be implicated in the aggregation and deposition of pseudoexfoliative material. Zenkel M, etal., Invest Ophthalmol Vis Sci. 2006 May;47(5):1982-90.
81. Urinary biomarkers track the progression of nephropathy in hypertensive and obese rats. Zhang Q, etal., Biomark Med. 2014 Jan;8(1):85-94. doi: 10.2217/bmm.13.106.
Additional References at PubMed
PMID:2299741   PMID:3415696   PMID:9228033   PMID:10066740   PMID:10694874   PMID:10837345   PMID:11123922   PMID:11697889   PMID:11865066   PMID:12047389   PMID:12145324   PMID:12176985  
PMID:12551933   PMID:14741101   PMID:15857407   PMID:15897157   PMID:15994859   PMID:16113678   PMID:16157419   PMID:16336210   PMID:16452087   PMID:16502470   PMID:16548883   PMID:16682745  
PMID:17412999   PMID:17451556   PMID:17455085   PMID:17567961   PMID:17689225   PMID:18321852   PMID:18942093   PMID:19056867   PMID:19137541   PMID:19199708   PMID:19878774   PMID:19996109  
PMID:20068069   PMID:20551380   PMID:20692254   PMID:21212797   PMID:21397462   PMID:21505792   PMID:21536718   PMID:21543606   PMID:21567405   PMID:21803450   PMID:21995960   PMID:22130675  
PMID:22138303   PMID:22179788   PMID:22197644   PMID:22516433   PMID:22689054   PMID:23106396   PMID:23376485   PMID:23533145   PMID:23658023   PMID:24006456   PMID:24080898   PMID:24446231  
PMID:25051234   PMID:25148511   PMID:25402950   PMID:25661013   PMID:25778834   PMID:26391229   PMID:26709877   PMID:26962868   PMID:27068509   PMID:27477018   PMID:27559042   PMID:29867124  
PMID:30111670   PMID:31113434   PMID:31406108   PMID:31882899   PMID:32942336   PMID:33755527   PMID:34242654   PMID:35244876   PMID:35352799  


Genomics

Comparative Map Data
Clu
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81544,336,619 - 44,375,861 (+)NCBIGRCr8
mRatBN7.21540,161,068 - 40,200,315 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1540,174,617 - 40,200,315 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1542,026,339 - 42,065,337 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01543,176,537 - 43,215,535 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01541,621,373 - 41,660,612 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01542,626,612 - 42,665,858 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1542,640,146 - 42,665,857 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01548,926,511 - 48,965,757 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41545,365,779 - 45,405,314 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11545,381,558 - 45,421,094 (+)NCBI
Celera1539,832,711 - 39,871,901 (+)NCBICelera
Cytogenetic Map15p12NCBI
CLU
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38827,596,917 - 27,614,700 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl827,596,917 - 27,614,700 (-)EnsemblGRCh38hg38GRCh38
GRCh37827,454,434 - 27,472,217 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36827,510,368 - 27,528,244 (-)NCBINCBI36Build 36hg18NCBI36
Build 34827,510,367 - 27,524,855NCBI
Celera826,414,541 - 26,432,416 (-)NCBICelera
Cytogenetic Map8p21.1NCBI
HuRef825,999,468 - 26,017,387 (-)NCBIHuRef
CHM1_1827,656,307 - 27,674,217 (-)NCBICHM1_1
T2T-CHM13v2.0827,874,264 - 27,892,057 (-)NCBIT2T-CHM13v2.0
Clu
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391466,206,093 - 66,218,992 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1466,205,932 - 66,218,996 (+)EnsemblGRCm39 Ensembl
GRCm381465,968,483 - 65,981,548 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1465,968,483 - 65,981,547 (+)EnsemblGRCm38mm10GRCm38
MGSCv371466,587,320 - 66,600,382 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361464,922,735 - 64,935,658 (+)NCBIMGSCv36mm8
Celera1451,264,543 - 51,272,775 (-)NCBICelera
Cytogenetic Map14D1NCBI
cM Map1434.36NCBI
Clu
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495540350,160,598 - 50,175,876 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495540350,160,598 - 50,175,876 (-)NCBIChiLan1.0ChiLan1.0
CLU
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2746,128,456 - 46,145,344 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1821,842,687 - 21,859,551 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0826,867,973 - 26,884,838 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1824,070,053 - 24,086,934 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl824,070,053 - 24,083,523 (-)Ensemblpanpan1.1panPan2
CLU
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12529,982,811 - 29,999,565 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2529,982,811 - 29,999,563 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha2530,569,577 - 30,586,344 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.02530,173,217 - 30,190,014 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl2530,173,100 - 30,195,919 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.12530,103,442 - 30,120,185 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02529,984,486 - 30,001,273 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02530,150,889 - 30,167,668 (+)NCBIUU_Cfam_GSD_1.0
Clu
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_0244049438,072,565 - 8,086,406 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_004936675499,199 - 513,836 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_004936675499,745 - 513,515 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
CLU
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1411,336,595 - 11,349,764 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11411,336,585 - 11,352,569 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21412,516,644 - 12,527,851 (-)NCBISscrofa10.2Sscrofa10.2susScr3
CLU
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1825,704,441 - 25,721,789 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl825,703,257 - 25,721,789 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366605216,420,009 - 16,437,520 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Clu
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462475822,426,918 - 22,444,357 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462475822,431,331 - 22,444,185 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Clu
106 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:45
Count of miRNA genes:41
Interacting mature miRNAs:44
Transcripts:ENSRNOT00000022095
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1331729Rf42Renal function QTL 423.071kidney blood vessel physiology trait (VT:0100012)absolute change in renal blood flow rate (CMO:0001168)151736289773690657Rat
1641887Alcrsp14Alcohol response QTL 14response to alcohol trait (VT:0010489)brain neurotensin receptor 1 density (CMO:0002068)15142356671Rat
1582227Gluco30Glucose level QTL 303.60.0003blood glucose amount (VT:0000188)absolute change in blood glucose level area under curve (CMO:0002034)152803066582262678Rat
1582228Epfw3Epididymal fat weight QTL 34.10.0002epididymal fat pad mass (VT:0010421)epididymal fat pad weight to body weight ratio (CMO:0000658)152803066582262678Rat
1578646Bmd18Bone mineral density QTL 185.2femur mineral mass (VT:0010011)trabecular volumetric bone mineral density (CMO:0001729)152280624098288169Rat
1578647Bmd17Bone mineral density QTL 174femur mineral mass (VT:0010011)total volumetric bone mineral density (CMO:0001728)152280624098288169Rat
10401805Kidm51Kidney mass QTL 51kidney mass (VT:0002707)both kidneys wet weight (CMO:0000085)1530632945306329Rat
2293686Bmd36Bone mineral density QTL 367.40.0001femur strength trait (VT:0010010)femoral neck ultimate force (CMO:0001703)153361105871477291Rat
2317750Glom26Glomerulus QTL 264.3urine protein amount (VT:0005160)urine protein level (CMO:0000591)151249614165205939Rat
2298549Neuinf12Neuroinflammation QTL 123.5nervous system integrity trait (VT:0010566)spinal cord beta-2 microglobulin mRNA level (CMO:0002125)15155302115Rat
2293691Bmd37Bone mineral density QTL 376.60.0001femur strength trait (VT:0010010)femur total energy absorbed before break (CMO:0001677)153361105871477291Rat
2293688Bss29Bone structure and strength QTL 295.310.0001femur morphology trait (VT:0000559)femur midshaft cortical cross-sectional area (CMO:0001663)151111114256111142Rat
1582214Stl21Serum triglyceride level QTL 213.10.022blood triglyceride amount (VT:0002644)serum triglyceride level (CMO:0000360)152803066582262678Rat
631273Lecl2Lens clarity QTL 20.001lens clarity trait (VT:0001304)age of onset/diagnosis of cataract (CMO:0001584)151059608955596089Rat
2300167Bmd63Bone mineral density QTL 635.90.0001femur mineral mass (VT:0010011)volumetric bone mineral density (CMO:0001553)151111114256111142Rat
731170Pur3Proteinuria QTL 32.30.0005urine protein amount (VT:0005160)urine protein excretion rate (CMO:0000759)15141686771Rat
738017Hcas7Hepatocarcinoma susceptibility QTL 72.91liver integrity trait (VT:0010547)liver nonremodeling tumorous lesion volume to total liver volume ratio (CMO:0001464)15226636846921453Rat
10054130Srcrt8Stress Responsive Cort QTL 82.180.0085blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)152211793367117933Rat
2300173Bmd62Bone mineral density QTL 6212.80.0001lumbar vertebra mineral mass (VT:0010511)volumetric bone mineral density (CMO:0001553)151111114256111142Rat
2324620Coatc3Coat color QTL 3coat/hair pigmentation trait (VT:0010463)pigmented coat/hair area to total coat/hair area ratio (CMO:0001810)151985656646187442Rat
61424Scl1Serum cholesterol level QTL 17.70.001blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)151672552880672115Rat
1582251Gluco24Glucose level QTL 243.20.0008blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)15553075650530756Rat
1598828Glom14Glomerulus QTL 142.5kidney glomerulus morphology trait (VT:0005325)index of glomerular damage (CMO:0001135)153405413979054139Rat
1582242Gluco28Glucose level QTL 283.30.0008blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)152803066582262678Rat
1582244Bw79Body weight QTL 7940.0002epididymal fat pad mass (VT:0010421)epididymal fat pad weight to body weight ratio (CMO:0000658)152803066582262678Rat
1578660Bss19Bone structure and strength QTL 194.3femur morphology trait (VT:0000559)bone trabecular cross-sectional area (CMO:0002311)152280624098288169Rat

Markers in Region
D15Wox2  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21540,193,236 - 40,193,417 (+)MAPPERmRatBN7.2
Rnor_6.01542,658,780 - 42,658,960NCBIRnor6.0
Rnor_5.01548,933,409 - 48,933,589UniSTSRnor5.0
RGSC_v3.41545,398,245 - 45,398,426RGDRGSC3.4
RGSC_v3.41545,398,246 - 45,398,426UniSTSRGSC3.4
RGSC_v3.11545,414,025 - 45,414,206RGD
Celera1539,864,833 - 39,865,013UniSTS
RH 3.4 Map15313.2UniSTS
RH 3.4 Map15313.2RGD
RH 2.0 Map15293.1RGD
Cytogenetic Map15p12UniSTS
D15Rat144  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21540,159,442 - 40,159,783 (+)MAPPERmRatBN7.2
Rnor_6.01542,624,987 - 42,625,327NCBIRnor6.0
Rnor_5.01548,967,041 - 48,967,382NCBIRnor5.0
RGSC_v3.41545,364,154 - 45,364,494UniSTSRGSC3.4
Celera1539,831,086 - 39,831,426UniSTS
SHRSP x BN Map1533.5499UniSTS
SHRSP x BN Map1533.5499RGD
Cytogenetic Map15p12UniSTS
D15Rat147  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21540,159,442 - 40,159,780 (+)MAPPERmRatBN7.2
Rnor_6.01542,624,987 - 42,625,324NCBIRnor6.0
Rnor_5.01548,967,044 - 48,967,382NCBIRnor5.0
RGSC_v3.41545,364,154 - 45,364,491UniSTSRGSC3.4
RGSC_v3.11545,379,921 - 45,380,573RGD
Celera1539,831,086 - 39,831,423UniSTS
SHRSP x BN Map1534.6299UniSTS
SHRSP x BN Map1534.6299RGD
Cytogenetic Map15p12UniSTS
D15Wox8  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21540,185,285 - 40,185,562 (+)MAPPERmRatBN7.2
Rnor_6.01542,650,827 - 42,651,103NCBIRnor6.0
Rnor_5.01548,941,266 - 48,941,542UniSTSRnor5.0
RGSC_v3.41545,390,293 - 45,390,569UniSTSRGSC3.4
Celera1539,856,943 - 39,857,219UniSTS
Cytogenetic Map15p12UniSTS
BE111829  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21540,191,060 - 40,191,243 (+)MAPPERmRatBN7.2
Rnor_6.01542,656,604 - 42,656,786NCBIRnor6.0
Rnor_5.01548,935,583 - 48,935,765UniSTSRnor5.0
RGSC_v3.41545,396,070 - 45,396,252UniSTSRGSC3.4
Celera1539,862,657 - 39,862,839UniSTS
RH 3.4 Map15310.2UniSTS
Cytogenetic Map15p12UniSTS
RH94609  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21540,200,124 - 40,200,297 (+)MAPPERmRatBN7.2
Rnor_6.01542,665,668 - 42,665,840NCBIRnor6.0
Rnor_5.01548,926,529 - 48,926,701UniSTSRnor5.0
RGSC_v3.41545,405,134 - 45,405,306UniSTSRGSC3.4
Celera1539,871,721 - 39,871,893UniSTS
Cytogenetic Map15p12UniSTS
Clu  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21540,198,817 - 40,199,676 (+)MAPPERmRatBN7.2
Rnor_6.01542,664,361 - 42,665,219NCBIRnor6.0
Rnor_5.01548,927,150 - 48,928,008UniSTSRnor5.0
RGSC_v3.41545,403,827 - 45,404,685UniSTSRGSC3.4
Celera1539,870,414 - 39,871,272UniSTS
Cytogenetic Map15p12UniSTS


Sequence

Nucleotide Sequences
RefSeq Transcripts NM_001431368 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001431369 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001431370 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001431371 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001431372 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001431373 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001431374 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001431375 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001431376 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001431377 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001431378 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_053021 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NR_197209 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006252094 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AF314657 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC061534 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH474023 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ209467 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ209498 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ209623 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ209843 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ211071 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ213163 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ213433 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ214098 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ214117 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ218237 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ218483 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ218812 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ219030 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JAXUCZ010000015 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  M16975 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  M64723 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  M64733 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  U02391 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  X13231 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Ensembl Acc Id: ENSRNOT00000022095   ⟹   ENSRNOP00000022095
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1540,187,524 - 40,200,315 (+)Ensembl
Rnor_6.0 Ensembl1542,653,148 - 42,665,857 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000078861   ⟹   ENSRNOP00000072116
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1540,174,617 - 40,200,305 (+)Ensembl
Rnor_6.0 Ensembl1542,640,146 - 42,665,848 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000091612   ⟹   ENSRNOP00000075645
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1540,190,354 - 40,200,315 (+)Ensembl
Rnor_6.0 Ensembl1542,659,371 - 42,665,853 (+)Ensembl
RefSeq Acc Id: NM_053021   ⟹   NP_444180
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81544,336,619 - 44,375,855 (+)NCBI
mRatBN7.21540,161,068 - 40,200,305 (+)NCBI
Rnor_6.01542,626,612 - 42,665,848 (+)NCBI
Rnor_5.01548,926,511 - 48,965,757 (-)NCBI
RGSC_v3.41545,365,779 - 45,405,314 (+)RGD
Celera1539,832,711 - 39,871,901 (+)RGD
Sequence:
RefSeq Acc Id: XM_006252094   ⟹   XP_006252156
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81544,362,800 - 44,375,861 (+)NCBI
mRatBN7.21540,187,496 - 40,200,315 (+)NCBI
Rnor_6.01542,653,045 - 42,665,858 (+)NCBI
Rnor_5.01548,926,511 - 48,965,757 (-)NCBI
Sequence:
Protein Sequences
Protein RefSeqs NP_001418297 (Get FASTA)   NCBI Sequence Viewer  
  NP_001418298 (Get FASTA)   NCBI Sequence Viewer  
  NP_001418299 (Get FASTA)   NCBI Sequence Viewer  
  NP_001418300 (Get FASTA)   NCBI Sequence Viewer  
  NP_001418301 (Get FASTA)   NCBI Sequence Viewer  
  NP_001418302 (Get FASTA)   NCBI Sequence Viewer  
  NP_001418303 (Get FASTA)   NCBI Sequence Viewer  
  NP_001418304 (Get FASTA)   NCBI Sequence Viewer  
  NP_001418305 (Get FASTA)   NCBI Sequence Viewer  
  NP_001418306 (Get FASTA)   NCBI Sequence Viewer  
  NP_001418307 (Get FASTA)   NCBI Sequence Viewer  
  NP_444180 (Get FASTA)   NCBI Sequence Viewer  
  XP_006252156 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAA18641 (Get FASTA)   NCBI Sequence Viewer  
  AAA41273 (Get FASTA)   NCBI Sequence Viewer  
  AAA42298 (Get FASTA)   NCBI Sequence Viewer  
  AAA42299 (Get FASTA)   NCBI Sequence Viewer  
  AAG31162 (Get FASTA)   NCBI Sequence Viewer  
  AAH61534 (Get FASTA)   NCBI Sequence Viewer  
  CAA31618 (Get FASTA)   NCBI Sequence Viewer  
  EDL85369 (Get FASTA)   NCBI Sequence Viewer  
  EDL85370 (Get FASTA)   NCBI Sequence Viewer  
  EDL85371 (Get FASTA)   NCBI Sequence Viewer  
  EDL85372 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000022095.5
  ENSRNOP00000072116.1
  ENSRNOP00000075645.2
GenBank Protein P05371 (Get FASTA)   NCBI Sequence Viewer  
RefSeq Acc Id: NP_444180   ⟸   NM_053021
- Peptide Label: precursor
- UniProtKB: A0A0G2K259 (UniProtKB/TrEMBL),   A6K6L1 (UniProtKB/TrEMBL),   Q6P7S6 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006252156   ⟸   XM_006252094
- Peptide Label: isoform X1
- UniProtKB: A0A0G2K259 (UniProtKB/TrEMBL),   A6K6L1 (UniProtKB/TrEMBL),   Q6P7S6 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000022095   ⟸   ENSRNOT00000022095
Ensembl Acc Id: ENSRNOP00000072116   ⟸   ENSRNOT00000078861
Ensembl Acc Id: ENSRNOP00000075645   ⟸   ENSRNOT00000091612
Protein Domains
Clusterin C-terminal   Clusterin N-terminal

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P05371-F1-model_v2 AlphaFold P05371 1-447 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13699765
Promoter ID:EPDNEW_R10275
Type:multiple initiation site
Name:Clu_1
Description:clusterin
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.01542,653,148 - 42,653,208EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:3907 AgrOrtholog
BioCyc Gene G2FUF-13340 BioCyc
Ensembl Genes ENSRNOG00000016460 Ensembl, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000022095.8 UniProtKB/TrEMBL
  ENSRNOT00000078861.2 UniProtKB/TrEMBL
  ENSRNOT00000091612.2 UniProtKB/TrEMBL
IMAGE_CLONE IMAGE:6886725 IMAGE-MGC_LOAD
InterPro Clusterin UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Clusterin-like UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Clusterin_C UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Clusterin_CS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Clusterin_N UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:24854 UniProtKB/Swiss-Prot
MGC_CLONE MGC:72717 IMAGE-MGC_LOAD
NCBI Gene Clu ENTREZGENE
PANTHER PTHR10970 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PTHR10970:SF1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam Clusterin UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Clu PhenoGen
PIRSF Clusterin UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE CLUSTERIN_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  CLUSTERIN_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
RatGTEx ENSRNOG00000016460 RatGTEx
SMART CLa UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  CLb UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A0A0G2K259 ENTREZGENE, UniProtKB/TrEMBL
  A0A0G2KB42_RAT UniProtKB/TrEMBL
  A6K6L1 ENTREZGENE, UniProtKB/TrEMBL
  A6K6L3_RAT UniProtKB/TrEMBL
  CLUS_RAT UniProtKB/Swiss-Prot
  G3V836_RAT UniProtKB/TrEMBL
  P05371 ENTREZGENE
  Q6P7S6 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2002-06-10 Clu  clusterin      Symbol and Name status set to approved 70586 APPROVED
2001-04-06 Trpm2  Testostrone-repressed prostate message 2      Symbol inconsistent with Human and Mouse 61478 WITHDRAWN
2001-04-06 Clu  Clusterin      Symbol and name changed to reflect Human and Mouse nomenclature 61478 APPROVED

RGD Curation Notes
Note Type Note Reference
gene_disease increase is associataed with Alzheimers disease and scleroderma-polymyositis syndrome 61515
gene_disease increase is associataed with Alzheimers disease and scleroderma-polymyositis syndrome 70775
gene_expression highly expressed in the nasal epithelial cells of the male F344 rat 61515
gene_expression highly expressed in the nasal epithelial cells of the male F344 rat 70775
gene_expression expression in seminal vesicle is regulated by androgen 727693
gene_process may be involved in spermatogenesis 61515
gene_process may be involved in spermatogenesis 70775
gene_process may be involved in apoptosis 727693