Tpo (thyroid peroxidase) - Rat Genome Database

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Gene: Tpo (thyroid peroxidase) Rattus norvegicus
Analyze
Symbol: Tpo
Name: thyroid peroxidase
RGD ID: 3900
Description: Predicted to enable iodide peroxidase activity. Involved in cellular response to nitric oxide and response to lipid. Located in cell surface. Human ortholog(s) of this gene implicated in congenital hypothyroidism; glomerulonephritis; and thyroid dyshormonogenesis 2A. Orthologous to human TPO (thyroid peroxidase); PARTICIPATES IN thyroid hormone biosynthetic pathway; autoimmune thyroiditis pathway; cytokine mediated signaling pathway; INTERACTS WITH (S)-naringenin; 1,3-benzothiazole-2-thiol; 2,2',4,4'-Tetrabromodiphenyl ether.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: truncated thyroid peroxidase
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8652,425,998 - 52,495,793 (-)NCBIGRCr8
mRatBN7.2646,698,402 - 46,768,199 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl646,698,414 - 46,768,199 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx647,003,424 - 47,073,172 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0647,318,282 - 47,388,031 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0646,753,566 - 46,823,319 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0649,020,918 - 49,089,855 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl649,021,044 - 49,089,855 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0657,702,091 - 57,770,914 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4647,954,848 - 48,025,740 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1647,957,973 - 48,028,866 (-)NCBI
Celera645,906,515 - 45,971,940 (-)NCBICelera
RH 3.4 Map6299.2RGD
Cytogenetic Map6q16NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(S)-naringenin  (EXP)
1,3-benzothiazole-2-thiol  (EXP,ISO)
17beta-hydroxy-5alpha-androstan-3-one  (ISO)
2,2',4,4'-Tetrabromodiphenyl ether  (EXP)
2,4-Dihydroxybenzophenone  (EXP)
4,4'-diaminodiphenylmethane  (EXP)
4-Aminophenyl ether  (EXP)
5-azacytidine  (ISO)
6-propyl-2-thiouracil  (EXP,ISO)
acrylamide  (EXP)
all-trans-retinoic acid  (ISO)
amiodarone  (EXP,ISO)
amitrole  (EXP,ISO)
ammonium chloride  (EXP)
arsane  (ISO)
arsenic atom  (ISO)
arsenous acid  (ISO)
asbestos  (ISO)
bathocuproine disulfonic acid  (EXP)
benzo[a]pyrene  (EXP,ISO)
benzo[e]pyrene  (ISO)
benzophenone  (ISO)
bis(2-chloroethyl) sulfide  (ISO)
bis(2-ethylhexyl) phthalate  (EXP)
bisphenol A  (EXP,ISO)
Butylparaben  (EXP)
C60 fullerene  (EXP)
cadmium dichloride  (ISO)
carbaryl  (ISO)
CGP 52608  (ISO)
copper atom  (EXP)
copper(0)  (EXP)
cyclosporin A  (ISO)
daidzein  (EXP,ISO)
decabromodiphenyl ether  (EXP)
diarsenic trioxide  (ISO)
dibenz[a,h]anthracene  (ISO)
dibutyl phthalate  (ISO)
doxorubicin  (ISO)
efavirenz  (ISO)
Ethylenethiourea  (ISO)
fulvestrant  (ISO)
genistein  (EXP,ISO)
glutathione  (ISO)
glyphosate  (EXP,ISO)
iodide salt  (ISO)
isoniazide  (EXP)
isoprenaline  (EXP)
mancozeb  (EXP)
melatonin  (ISO)
methapyrilene  (ISO)
methimazole  (EXP,ISO)
minocycline  (EXP)
mono(2-ethylhexyl) phthalate  (ISO)
Muraglitazar  (EXP)
N-acetyl-L-cysteine  (EXP)
N-Vinyl-2-pyrrolidone  (EXP)
nevirapine  (ISO)
nitrogen dioxide  (ISO)
o-anisidine  (EXP)
oxymetholone  (ISO)
ozone  (ISO)
perchlorate  (EXP)
perfluorooctane-1-sulfonic acid  (ISO)
perfluorooctanoic acid  (EXP)
phenobarbital  (EXP)
potassium iodide  (EXP)
pregnenolone 16alpha-carbonitrile  (EXP)
propanal  (ISO)
pyridine-2,3-diol  (EXP)
pyrrolidine dithiocarbamate  (EXP)
quercetin  (EXP)
resorcinol  (EXP,ISO)
resveratrol  (EXP)
salicylhydroxamic acid  (EXP)
silver atom  (ISO)
silver(0)  (ISO)
silver(1+) nitrate  (ISO)
sodium arsenite  (ISO)
sodium azide  (EXP)
sodium iodide  (ISO)
sodium nitrate  (EXP)
sodium perchlorate  (EXP)
Tesaglitazar  (EXP)
testosterone  (ISO)
thiram  (ISO)
thyroxine  (EXP)
triclocarban  (EXP)
triclosan  (EXP,ISO)
triphenyl phosphate  (EXP)
troglitazone  (EXP)
valproic acid  (ISO)
vemurafenib  (ISO)
vinclozolin  (ISO)
vorinostat  (ISO)
zineb  (ISO)
ziram  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Nitric oxide/cGMP signaling inhibits TSH-stimulated iodide uptake and expression of thyroid peroxidase and thyroglobulin mRNA in FRTL-5 thyroid cells. Bazzara LG, etal., Thyroid. 2007 Aug;17(8):717-27.
2. Identification of five novel inactivating mutations in the human thyroid peroxidase gene by denaturing gradient gel electrophoresis. Bikker H, etal., Hum Mutat. 1995;6(1):9-16.
3. Complete nucleotide sequence of the cDNA for thyroid peroxidase in FRTL5 rat thyroid cells. Derwahl M, etal., Nucleic Acids Res 1989 Oct 25;17(20):8380.
4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
5. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
6. Thyroid peroxidase: rat cDNA sequence, chromosomal localization in mouse, and regulation of gene expression by comparison to thyroglobulin in rat FRTL-5 cells. Isozaki O, etal., Mol Endocrinol. 1989 Nov;3(11):1681-92.
7. KEGG: Kyoto Encyclopedia of Genes and Genomes KEGG
8. Intracellular trafficking of thyroid peroxidase to the cell surface. Kuliawat R, etal., J Biol Chem. 2005 Jul 29;280(30):27713-8. Epub 2005 May 24.
9. High-density rat radiation hybrid maps containing over 24,000 SSLPs, genes, and ESTs provide a direct link to the rat genome sequence. Kwitek AE, etal., Genome Res. 2004 Apr;14(4):750-7
10. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
11. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
12. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
13. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
14. SMPDB Annotation Import Pipeline Pipeline to import SMPDB annotations from SMPDB into RGD
15. GOA pipeline RGD automated data pipeline
16. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
17. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
18. Pretransplant positivity for circulating thyroid antibodies and graft survival in patients undergoing kidney transplant. Rotondi M, etal., Horm Res. 2009;71(6):324-30. doi: 10.1159/000223416. Epub 2009 Jun 6.
19. Effects of a dietary thermally oxidized fat on thyroid morphology and mRNA concentrations of thyroidal iodide transporter and thyroid peroxidase in rats. Skufca P, etal., Ann Nutr Metab. 2003;47(5):207-13.
20. Increased prevalence of thyroid peroxidase antibodies (TPO-Ab) in women with glomerulonephritis. Westman KW, etal., Nephrol Dial Transplant. 1993;8(5):402-6.
Additional References at PubMed
PMID:2233737   PMID:12387814   PMID:14651853   PMID:17379648   PMID:17709379   PMID:20629314   PMID:21149635   PMID:21619833   PMID:22664934   PMID:23064013   PMID:24625548   PMID:26610751  
PMID:31439949  


Genomics

Comparative Map Data
Tpo
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8652,425,998 - 52,495,793 (-)NCBIGRCr8
mRatBN7.2646,698,402 - 46,768,199 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl646,698,414 - 46,768,199 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx647,003,424 - 47,073,172 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0647,318,282 - 47,388,031 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0646,753,566 - 46,823,319 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0649,020,918 - 49,089,855 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl649,021,044 - 49,089,855 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0657,702,091 - 57,770,914 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4647,954,848 - 48,025,740 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1647,957,973 - 48,028,866 (-)NCBI
Celera645,906,515 - 45,971,940 (-)NCBICelera
RH 3.4 Map6299.2RGD
Cytogenetic Map6q16NCBI
TPO
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh3821,374,047 - 1,543,673 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl21,374,066 - 1,543,711 (+)EnsemblGRCh38hg38GRCh38
GRCh3721,417,235 - 1,547,445 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 3621,396,242 - 1,525,502 (+)NCBINCBI36Build 36hg18NCBI36
Build 3421,396,241 - 1,525,502NCBI
Celera21,466,953 - 1,592,423 (+)NCBICelera
Cytogenetic Map2p25.3NCBI
HuRef21,408,795 - 1,531,941 (+)NCBIHuRef
CHM1_121,409,624 - 1,546,343 (+)NCBICHM1_1
T2T-CHM13v2.021,414,928 - 1,549,090 (+)NCBIT2T-CHM13v2.0
Tpo
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391230,104,658 - 30,182,983 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1230,104,658 - 30,182,623 (-)EnsemblGRCm39 Ensembl
GRCm381230,054,659 - 30,132,984 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1230,054,659 - 30,132,624 (-)EnsemblGRCm38mm10GRCm38
MGSCv371230,739,526 - 30,817,474 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361230,640,713 - 30,718,661 (-)NCBIMGSCv36mm8
Celera1231,518,105 - 31,587,543 (-)NCBICelera
Cytogenetic Map12A2NCBI
cM Map1213.0NCBI
Tpo
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_004955487494,746 - 529,416 (-)EnsemblChiLan1.0
ChiLan1.0NW_004955487485,029 - 530,287 (-)NCBIChiLan1.0ChiLan1.0
TPO
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v212125,044,194 - 125,171,557 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan12A125,048,171 - 125,175,534 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v02A1,364,083 - 1,491,284 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.12A1,334,608 - 1,493,308 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl2A1,335,556 - 1,493,055 (+)Ensemblpanpan1.1panPan2
TPO
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.117773,790 - 810,044 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl17773,790 - 810,043 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha17760,899 - 796,526 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.017830,903 - 866,744 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl17831,063 - 866,737 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.117755,185 - 790,848 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.017775,417 - 811,064 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.017775,279 - 810,948 (+)NCBIUU_Cfam_GSD_1.0
Tpo
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440629245,635,285 - 45,680,483 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_004936532390,327 - 429,386 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_004936532391,181 - 435,132 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
TPO
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl3132,384,583 - 132,409,208 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.13132,384,677 - 132,409,750 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.23141,795,655 - 141,820,693 (-)NCBISscrofa10.2Sscrofa10.2susScr3
TPO
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.114106,148,214 - 106,255,442 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl14106,146,946 - 106,255,298 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_0236660455,734,964 - 5,848,587 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Tpo
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248461,934,469 - 1,961,291 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046248461,934,084 - 1,962,637 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Tpo
218 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:43
Count of miRNA genes:38
Interacting mature miRNAs:43
Transcripts:ENSRNOT00000006526
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
9590290Uminl2Urine mineral level QTL 23.960.001urine mineral amount (VT:0015086)urine electrolyte level (CMO:0000593)63878398983783989Rat
8693632Alc27Alcohol consumption QTL 272.20.791drinking behavior trait (VT:0001422)calculated ethanol drink intake rate (CMO:0001615)63432335751121479Rat
634318Bw118Body weight QTL 1183.55abdominal fat pad mass (VT:1000711)abdominal fat pad weight (CMO:0000088)63330954957730294Rat
10401812Kidm54Kidney mass QTL 54kidney mass (VT:0002707)both kidneys wet weight (CMO:0000085)61436878859368788Rat
634307Bp141Blood pressure QTL 1414arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)63523041780230417Rat
2292589Emca10Estrogen-induced mammary cancer QTL 100.048mammary gland integrity trait (VT:0010552)post-insult time to mammary tumor formation (CMO:0000345)61653614061536140Rat
634330Pia16Pristane induced arthritis QTL 163.9joint integrity trait (VT:0010548)arthritic paw count (CMO:0001460)645790088104200226Rat
10401800Kidm49Kidney mass QTL 49kidney mass (VT:0002707)both kidneys wet weight (CMO:0000085)61436878859368788Rat
1300164Rf15Renal function QTL 153.12renal blood flow trait (VT:2000006)absolute change in renal blood flow rate (CMO:0001168)6507449754641141Rat
1331779Rf38Renal function QTL 382.876kidney blood vessel physiology trait (VT:0100012)absolute change in renal vascular resistance (CMO:0001900)63207442872227641Rat
1354632Scl29Serum cholesterol level QTL 293.74blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)63509870971636405Rat
4145119Mcs25Mammary carcinoma susceptibility QTL 250.0001mammary gland integrity trait (VT:0010552)ratio of deaths to total study population during a period of time (CMO:0001023)610894415110548006Rat
2293839Kiddil2Kidney dilation QTL 24.8kidney pelvis morphology trait (VT:0004194)hydronephrosis severity score (CMO:0001208)62086642281133036Rat
1576309Emca7Estrogen-induced mammary cancer QTL 74mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)615107216107351382Rat
9590140Scort4Serum corticosterone level QTL 414.490.001blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)63878398983783989Rat
9590306Scort18Serum corticosterone level QTL 182.880.001blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)63878398983783989Rat
1578665Bss16Bone structure and strength QTL 164.4femur morphology trait (VT:0000559)bone trabecular cross-sectional area (CMO:0002311)61173566972593685Rat
2293841Kiddil4Kidney dilation QTL 44.4kidney pelvis morphology trait (VT:0004194)hydronephrosis severity score (CMO:0001208)62086642281133036Rat
1641898Colcr4Colorectal carcinoma resistance QTL43.710.0007intestine integrity trait (VT:0010554)well differentiated malignant colorectal tumor surface area measurement (CMO:0002077)62033877762613667Rat
1578668Bmd14Bone mineral density QTL 143.8femur mineral mass (VT:0010011)total volumetric bone mineral density (CMO:0001728)61173566972593685Rat
6893340Cm77Cardiac mass QTL 770.260.57heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)63330954981132889Rat
70199Coreg1Compensatory renal growth QTL 111.8kidney mass (VT:0002707)compensatory renal growth score (CMO:0001894)63569161857730540Rat
2301972Bp325Blood pressure QTL 3254.8arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)6172227641Rat
1354664Slep2Serum leptin concentration QTL 24.49blood leptin amount (VT:0005667)serum leptin level (CMO:0000780)61653614071636405Rat
1300143Rf14Renal function QTL 142.92renal blood flow trait (VT:2000006)absolute change in renal blood flow rate (CMO:0001168)63443413777102317Rat

Markers in Region
RH94606  
Rat AssemblyChrPosition (strand)SourceJBrowse
RH 3.4 Map6299.2UniSTS
Cytogenetic Map6q16UniSTS
Tpo  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2646,739,489 - 46,740,973 (+)MAPPERmRatBN7.2
Rnor_6.0649,061,147 - 49,062,630NCBIRnor6.0
Rnor_5.0657,742,206 - 57,743,689UniSTSRnor5.0
RGSC_v3.4647,997,031 - 47,998,514UniSTSRGSC3.4
Celera645,943,229 - 45,944,712UniSTS
Cytogenetic Map6q16UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
nervous system
renal system
reproductive system
respiratory system
6 1 8 24 24 26 7 6 7 6 42 27 11 1 34 19

Sequence


Ensembl Acc Id: ENSRNOT00000006526   ⟹   ENSRNOP00000006526
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl646,698,414 - 46,768,199 (-)Ensembl
Rnor_6.0 Ensembl649,021,044 - 49,089,855 (-)Ensembl
RefSeq Acc Id: NM_019353   ⟹   NP_062226
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8652,425,998 - 52,495,793 (-)NCBI
mRatBN7.2646,698,402 - 46,768,199 (-)NCBI
Rnor_6.0649,021,032 - 49,089,855 (-)NCBI
Rnor_5.0657,702,091 - 57,770,914 (-)NCBI
RGSC_v3.4647,954,848 - 48,025,740 (-)RGD
Celera645,906,515 - 45,971,940 (-)NCBI
Sequence:
Protein Sequences
Protein RefSeqs NP_062226 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAA42250 (Get FASTA)   NCBI Sequence Viewer  
  AAA42265 (Get FASTA)   NCBI Sequence Viewer  
  CAA35257 (Get FASTA)   NCBI Sequence Viewer  
  EDM03234 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000006526.1
GenBank Protein P14650 (Get FASTA)   NCBI Sequence Viewer  
RefSeq Acc Id: NP_062226   ⟸   NM_019353
- Peptide Label: precursor
- UniProtKB: F1LN48 (UniProtKB/TrEMBL),   A6HB29 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000006526   ⟸   ENSRNOT00000006526
Protein Domains
EGF-like   Sushi

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P14650-F1-model_v2 AlphaFold P14650 1-914 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:3900 AgrOrtholog
BioCyc Gene G2FUF-37937 BioCyc
BioCyc Pathway PWY-6241 [thyroid hormone biosynthesis] BioCyc
BioCyc Pathway Image PWY-6241 BioCyc
Ensembl Genes ENSRNOG00000004646 Ensembl, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000006526.4 UniProtKB/TrEMBL
Gene3D-CATH 1.10.640.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Complement Module, domain 1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Laminin UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro EGF-like_Ca-bd_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  EGF-like_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  EGF-type_Asp/Asn_hydroxyl_site UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  EGF_Ca-bd_CS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Haem_peroxidase_animal UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Haem_peroxidase_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Haem_peroxidase_sf_animal UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  NOTCH1_EGF-like UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Peroxidase/ROS_Generation UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Sushi/SCR/CCP_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Sushi_SCR_CCP_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  TPO UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:54314 UniProtKB/TrEMBL
NCBI Gene 54314 ENTREZGENE
PANTHER OXIDASE/PEROXIDASE UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PTHR11475:SF60 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam An_peroxidase UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  EGF_CA UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Sushi UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Tpo PhenoGen
PRINTS ANPEROXIDASE UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE ASX_HYDROXYL UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  EGF_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  EGF_3 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  EGF_CA UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PEROXIDASE_1 UniProtKB/Swiss-Prot
  PEROXIDASE_3 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SUSHI UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
RatGTEx ENSRNOG00000004646 RatGTEx
SMART CCP UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  EGF UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  EGF_CA UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP EGF/Laminin UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SSF48113 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SSF57535 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A6HB29 ENTREZGENE, UniProtKB/TrEMBL
  F1LN48 ENTREZGENE, UniProtKB/TrEMBL
  P14650 ENTREZGENE, UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2002-06-10 Tpo  Thyroid peroxidase      Symbol and Name status set to approved 70586 APPROVED