Tp53 (tumor protein p53) - Rat Genome Database

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Gene: Tp53 (tumor protein p53) Rattus norvegicus
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Symbol: Tp53
Name: tumor protein p53
RGD ID: 3889
Description: Enables several functions, including MDM2/MDM4 family protein binding activity; protein C-terminus binding activity; and transmembrane transporter binding activity. Involved in several processes, including cellular response to triglyceride; regulation of apoptotic process; and regulation of nucleobase-containing compound metabolic process. Located in several cellular components, including chromatin; cytosol; and mitochondrion. Part of RNA polymerase II transcription regulator complex. Colocalizes with PML body. Used to study disease of cellular proliferation (multiple) and oral mucosa leukoplakia. Biomarker of several diseases, including dilated cardiomyopathy; gastrointestinal system cancer (multiple); ischemia; oral mucosa leukoplakia; and vascular dementia. Human ortholog(s) of this gene implicated in several diseases, including Li-Fraumeni syndrome (multiple); carcinoma (multiple); gastrointestinal system cancer (multiple); hematologic cancer (multiple); and open-angle glaucoma (multiple). Orthologous to human TP53 (tumor protein p53); PARTICIPATES IN altered p53 signaling pathway; endometrial cancer pathway; non-small cell lung carcinoma pathway; INTERACTS WITH (+)-schisandrin B; (-)-anisomycin; (-)-citrinin.
Type: protein-coding
RefSeq Status: REVIEWED
Previously known as: cellular tumor antigen p53; MGC112612; p53; transformation related protein 53; Trp53; tumor protein p53 (Li-Fraumeni syndrome); tumor suppressor p53
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Related Pseudogenes: Tp53-ps3   p53-ps  
Allele / Splice: Tp53em3Mcwi   Tp53m1Kyo   Tp53tm1(EGFP-Pac)Qly   Tp53em1Sage  
Genetic Models: SD-Tp53em1Sage STOCK-Tp53tm1(EGFP-Pac)Qly/Rrrc F344-Tp53m1Kyo SD-Tp53em3Mcwi
Is Marker For: Strains:   STOCK-Tp53tm1(EGFP-Pac)Qly/Rrrc   F344-Tp53m1Kyo  
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.21054,300,070 - 54,311,525 (+)NCBImRatBN7.2
mRatBN7.2 Ensembl1054,300,048 - 54,311,524 (+)Ensembl
Rnor_6.01056,186,299 - 56,198,449 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1056,187,020 - 56,198,449 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01055,932,658 - 55,944,087 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41056,399,721 - 56,411,150 (+)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.11056,413,290 - 56,424,751 (+)NCBI
Celera1053,454,375 - 53,465,803 (+)NCBICelera
Cytogenetic Map10q24NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model