Tnf (tumor necrosis factor) - Rat Genome Database

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Gene: Tnf (tumor necrosis factor) Rattus norvegicus
Symbol: Tnf
Name: tumor necrosis factor
RGD ID: 3876
Description: Enables tumor necrosis factor receptor binding activity. Involved in several processes, including negative regulation of transport; positive regulation of cell communication; and positive regulation of macromolecule metabolic process. Located in external side of plasma membrane; extracellular space; and neuronal cell body. Is active in extracellular region. Used to study several diseases, including cerebrovascular disease (multiple); liver disease (multiple); peptic esophagitis; perinatal necrotizing enterocolitis; and periventricular leukomalacia. Biomarker of several diseases, including artery disease (multiple); brain disease (multiple); congestive heart failure (multiple); liver disease (multiple); and lung disease (multiple). Human ortholog(s) of this gene implicated in several diseases, including artery disease (multiple); autoimmune disease (multiple); eye disease (multiple); lung disease (multiple); and skin disease (multiple). Orthologous to human TNF (tumor necrosis factor); PARTICIPATES IN pro-inflammatory cytokine mediated pathway; ceramide signaling pathway; Fc epsilon receptor mediated signaling pathway; INTERACTS WITH (+)-catechin; (+)-pilocarpine; (+)-taxifolin.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: cachectin; LOC103694380; MGC124630; RATTNF; TNF-a; TNF-alpha; Tnfa; tumor necrosis factor (TNF superfamily, member 2); tumor necrosis factor alpha; tumor necrosis factor ligand superfamily member 2; tumor necrosis factor superfamily member 2; tumor necrosis factor superfamily, member 2; tumor necrosis factor-alpha; tumor necrosis factor-like
RGD Orthologs
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Is Marker For: QTLs:   Bp144  
Candidate Gene For: Edcs3
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Rat AssemblyChrPosition (strand)SourceGenome Browsers
GRCr8203,626,685 - 3,629,303 (+)NCBIGRCr8
mRatBN7.2203,622,011 - 3,624,629 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl203,622,011 - 3,624,629 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx204,321,864 - 4,324,463 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0203,683,924 - 3,686,523 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0204,221,516 - 4,224,112 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0205,189,382 - 5,192,000 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl205,189,390 - 5,192,000 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_6.0 Ensembl204,855,829 - 4,858,447 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0206,936,229 - 6,938,847 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4203,661,000 - 3,663,618 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera204,400,860 - 4,403,478 (-)NCBICelera
RH 3.4 Map20 RGD
Cytogenetic Map20p12NCBI
JBrowse: View Region in Genome Browser (JBrowse)