Tlr4 (toll-like receptor 4) - Rat Genome Database

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Gene: Tlr4 (toll-like receptor 4) Rattus norvegicus
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Symbol: Tlr4
Name: toll-like receptor 4
RGD ID: 3870
Description: Enables lipopolysaccharide binding activity and phosphatidylinositol 3-kinase binding activity. Involved in several processes, including cellular response to lipid; detection of stimulus involved in sensory perception of pain; and response to steroid hormone. Located in cell surface. Used to study several diseases, including carotid stenosis; ileitis; neuropathy (multiple); obesity; and renal fibrosis. Biomarker of several diseases, including kidney failure (multiple); liver disease (multiple); pancreatitis (multiple); perinatal necrotizing enterocolitis; and pulpitis. Human ortholog(s) of this gene implicated in several diseases, including allergic contact dermatitis (multiple); artery disease (multiple); autoimmune disease (multiple); eye disease (multiple); and lung disease (multiple). Orthologous to human TLR4 (toll like receptor 4); PARTICIPATES IN Toll-like receptor signaling pathway; titanium dioxide nanoparticle response pathway; Chagas disease pathway; INTERACTS WITH (+)-pilocarpine; (S)-nicotine; 17beta-estradiol.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: toll4
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Allele / Splice: Tlr4m1Mcwi   Tlr4em1Geh   Tlr4em1Mcwi   Tlr4em5Mcwi  
Genetic Models: WI-Tlr4em1Geh FHH-Tlr4m1Mcwi BBDR.BBDP-(D4Mit6-D4Mit7)-Tlr4em5Mcwi SS-Tlr4em1Mcwi
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8585,161,247 - 85,174,882 (+)NCBIGRCr8
mRatBN7.2580,145,867 - 80,159,501 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl580,145,826 - 80,159,628 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx582,524,918 - 82,538,532 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0584,342,217 - 84,355,831 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0584,317,856 - 84,331,470 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0582,587,424 - 82,601,056 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl582,587,420 - 82,601,052 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0586,690,670 - 86,704,302 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4583,564,100 - 83,577,735 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1583,569,212 - 83,582,848 (+)NCBI
Celera579,045,293 - 79,058,928 (+)NCBICelera
RH 3.4 Map5643.7RGD
Cytogenetic Map5q24NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View
Acanthamoeba Keratitis  (IEP)
acne  (ISO)
Acne Conglobata  (ISO)
Acute Coronary Syndrome  (ISO)
acute kidney failure  (IDA,ISO)
Acute Liver Failure  (IEP,IMP)
Acute Lung Injury  (IEP)
acute necrotizing pancreatitis  (IEP)
acute pancreatitis  (ISO)
Acute Tubulointerstitial Nephritis  (ISO)
Acute-On-Chronic Liver Failure  (IEP)
Alcoholic Fatty Liver  (ISO)
allergic conjunctivitis  (ISO)
allergic contact dermatitis  (ISO)
allergic rhinitis  (ISO)
Alzheimer's disease  (ISO)
ankylosing spondylitis  (ISO)
anogenital venereal wart  (ISO)
anterior uveitis  (ISO)
arteriosclerosis  (ISO)
arthritis  (ISO)
asthma  (ISO)
atherosclerosis  (ISO)
atopic dermatitis  (ISO)
Bacteremia  (ISO)
Bacterial Keratitis  (ISO)
bacterial pneumonia  (ISO)
Behcet's disease  (ISO)
Brain Injuries  (IEP,ISO)
brain ischemia  (ISO)
breast cancer  (ISO)
Bronchial Hyperreactivity  (ISO)
carcinoma  (ISO)
carotid artery disease  (ISO)
carotid stenosis  (IDA)
Chemical and Drug Induced Liver Injury  (IEP)
cholesteatoma  (ISO)
cholesteatoma of middle ear  (ISO)
Chronic Hepatitis B  (ISO)
Chronic Hepatitis C  (ISO)
Chronic Intermittent Hypoxia  (IMP)
chronic obstructive pulmonary disease  (ISO)
Chronic Pain  (ISO)
Chronic Periodontitis  (ISO)
colitis  (IEP,ISO)
Colorectal Neoplasms  (ISO)
contact dermatitis  (ISO)
coronary artery disease  (ISO)
COVID-19  (ISO)
Crohn's disease  (ISO)
cutaneous leishmaniasis  (ISO)
cystic echinococcosis  (ISO)
cystic fibrosis  (ISO)
dermatomyositis  (ISO)
diabetes mellitus  (ISO)
Diabetic Foot  (ISO)
Diabetic Nephropathies  (ISO)
diabetic neuropathy  (IDA,ISO)
diabetic retinopathy  (ISO)
dry eye syndrome  (ISO)
Dysbiosis  (ISO)
end stage renal disease  (ISO)
Endotoxemia  (IDA,ISO)
Entamoebiasis  (ISO)
Eosinophilia  (ISO)
Escherichia Coli Meningitis  (ISO)
esophagus adenocarcinoma  (ISO)
essential hypertension  (ISO)
eumycotic mycetoma  (ISO)
exfoliation syndrome  (ISO)
Experimental Autoimmune Encephalomyelitis  (IEP)
Experimental Autoimmune Neuritis  (IEP)
Experimental Autoimmune Uveitis  (ISO)
Experimental Diabetes Mellitus  (IEP)
Experimental Liver Cirrhosis  (IDA,ISO)
extrahepatic cholestasis  (ISO)
eye disease  (ISO)
familial mediterranean fever  (ISO)
Fibrosis  (ISO)
Fungal Eye Infections  (IEP)
Fungal Keratitis  (ISO)
genetic disease  (ISO)
glomerulonephritis  (ISO)
Hearing Loss  (ISO)
Hemorrhagic Shock  (ISO)
hepatocellular carcinoma  (ISO)
hepatorenal syndrome  (IEP)
Herpes Simplex Encephalitis  (IEP)
herpes simplex virus keratitis  (ISO)
Hyperalgesia  (IMP,ISO)
hypertension  (ISO)
ileitis  (IMP,ISO)
Inflammation  (ISO)
Insulin Resistance  (ISO)
invasive aspergillosis  (ISO)
Kawasaki disease  (ISO)
keratitis  (ISO)
kidney failure  (IEP,ISO)
Kidney Reperfusion Injury  (IDA,ISO)
learning disability  (ISO)
leptospirosis  (ISO)
liver cirrhosis  (IEP,IMP,ISO)
Liver Injury  (ISO)
Liver Reperfusion Injury  (IEP,ISO)
low tension glaucoma  (ISO)
lung adenocarcinoma  (ISO)
lung disease  (IDA,IEP,ISO)
Lung Injury  (ISO)
Lung Neoplasms  (ISO)
Lung Reperfusion Injury  (IEP)
Lymphatic Metastasis  (ISO)
macular degeneration  (ISO)
mastitis  (IEP)
mastoiditis  (ISO)
melanoma  (ISO)
membranoproliferative glomerulonephritis  (ISO)
meningococcal meningitis  (ISO)
metabolic dysfunction-associated steatotic liver disease  (IEP,ISO)
multiple sclerosis  (ISO)
myocardial infarction  (ISO)
Myocardial Reperfusion Injury  (IDA)
Nasal Polyps  (ISO)
Neoplasm Invasiveness  (ISO)
Neoplasm Metastasis  (ISO)
Neuralgia  (IEP)
obesity  (IMP,ISO)
Ocular Onchocerciasis  (ISO)
Optic Nerve Injuries  (ISO)
Oral Lichen Planus  (ISO)
otitis media  (ISO)
Otitis Media with Effusion  (ISO)
Ovarian Neoplasms  (ISO)
Pain  (IMP)
Painful Neuropathy  (ISO)
pancreatitis  (IEP,ISO)
perinatal necrotizing enterocolitis  (IEP,ISO)
periodontitis  (ISO)
Plaque, Atherosclerotic  (ISO)
pleural tuberculosis  (ISO)
Pneumococcal Meningitis  (ISO)
pneumonia  (ISO)
pre-eclampsia  (ISO)
primary open angle glaucoma  (ISO)
Prostatic Neoplasms  (ISO)
Pseudomonas Aeruginosa Keratitis  (ISO)
psoriasis  (ISO)
pulmonary edema  (ISO)
pulmonary emphysema  (ISO,ISS)
pulmonary fibrosis  (ISO)
pulmonary hypertension  (ISO)
pulmonary tuberculosis  (ISO)
pulpitis  (IEP)
renal fibrosis  (IMP)
Reperfusion Injury  (IEP,ISO)
respiratory allergy  (ISO)
Respiratory Sounds  (ISO)
respiratory syncytial virus infectious disease  (ISO)
Retina Reperfusion Injury  (ISO)
Rhinosinusitis  (ISO)
sciatic neuropathy  (IEP,IMP,ISO)
Seasonal Allergic Rhinitis  (ISO)
Sepsis  (IEP,ISO)
severe COVID-19  (ISO)
sinusitis  (ISO)
Spinal Cord Injuries  (ISO)
Spinal Cord Reperfusion Injury  (IMP)
sporotrichosis  (ISO)
squamous cell carcinoma  (ISO)
Stable Angina  (ISO)
steatotic liver disease  (ISO)
Stroke  (ISO)
Subarachnoid Hemorrhage  (IEP)
suppurative otitis media  (ISO)
systemic lupus erythematosus  (ISO)
temporal arteritis  (ISO)
Transplant Rejection  (ISO)
tuberculosis  (ISO)
tympanosclerosis  (ISO)
type 1 diabetes mellitus  (ISO)
type 2 diabetes mellitus  (ISO)
urinary bladder cancer  (ISO)
urinary tract infection  (ISO)
uveitis  (IEP)
Ventricular Dysfunction, Left  (ISO)
Viral Bronchiolitis  (ISO)
viral meningitis  (ISO)
vitiligo  (ISO)
Wallerian Degeneration  (ISO)
Weight Loss  (ISO)

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-catechin  (ISO)
(+)-epicatechin-3-O-gallate  (ISO)
(+)-pilocarpine  (EXP)
(-)-demecolcine  (ISO)
(-)-epigallocatechin 3-gallate  (ISO)
(24S)-24-hydroxycholesterol  (ISO)
(25R)-cholest-5-ene-3beta,26-diol  (ISO)
(S)-nicotine  (EXP,ISO)
1,2-dichloroethane  (ISO)
1,2-dimethylhydrazine  (ISO)
1,4-dithiothreitol  (ISO)
1,4-phenylenediamine  (ISO)
1-[(2,3,4-trimethoxyphenyl)methyl]piperazine  (ISO)
1-chloro-2,4,6-trinitrobenzene  (ISO)
1-chloro-2,4-dinitrobenzene  (ISO)
1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine  (ISO)
17beta-estradiol  (EXP)
17beta-hydroxy-5alpha-androstan-3-one  (ISO)
2,2',4,4',5,5'-hexachlorobiphenyl  (ISO)
2,2,2-trichloroethanol  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,4,6-trinitrobenzenesulfonic acid  (EXP,ISO)
2-(4-iodo-2,5-dimethoxyphenyl)-1-methylethylamine  (EXP)
2-amino-2-deoxy-D-galactopyranose  (ISO)
26-hydroxycholesterol  (ISO)
3,3',4,4',5-pentachlorobiphenyl  (ISO)
3,3',5,5'-tetrabromobisphenol A  (EXP,ISO)
3,4-dihydroxybenzoic acid  (ISO)
3,4-methylenedioxymethamphetamine  (ISO)
3,5-diethoxycarbonyl-1,4-dihydrocollidine  (ISO)
3-isobutyl-1-methyl-7H-xanthine  (ISO)
3-phenylprop-2-enal  (ISO)
4,4'-sulfonyldiphenol  (ISO)
4-hydroxy-3-[4-(2-hydroxyphenyl)phenyl]-6-oxo-7H-thieno[2,3-b]pyridine-5-carbonitrile  (ISO)
4-hydroxynon-2-enal  (ISO)
4-hydroxyphenyl retinamide  (ISO)
4-methyl-3-[[1-oxo-2-(propylamino)propyl]amino]-2-thiophenecarboxylic acid methyl ester  (ISO)
5-aza-2'-deoxycytidine  (ISO)
5-fluorouracil  (EXP)
5-methoxy-2-\{[(4-methoxy-3,5-dimethylpyridin-2-yl)methyl]sulfinyl\}-1H-benzimidazole  (EXP)
6-chloro-2,3,4,9-tetrahydro-1H-carbazole-1-carboxamide  (ISO)
6-propyl-2-thiouracil  (EXP)
7alpha-hydroxycholesterol  (ISO)
acetamide  (EXP)
acetate ester  (ISO)
acetic acid  (EXP,ISO)
acrolein  (ISO)
acrylamide  (ISO)
adenosine  (ISO)
aflatoxin B1  (EXP,ISO)
agomelatine  (EXP)
aldehydo-D-glucose  (EXP,ISO)
all-trans-retinoic acid  (ISO)
all-trans-retinol  (ISO)
alpha-D-galactose  (EXP,ISO)
alpha-pinene  (ISO)
Alternaramide  (ISO)
aluminium hydroxide  (ISO)
amitrole  (EXP)
ammonium chloride  (EXP)
ampicillin  (ISO)
anethole  (EXP)
antirheumatic drug  (ISO)
apigenin  (ISO)
arachidonic acid  (EXP)
arsane  (ISO)
arsenic atom  (ISO)
arsenite(3-)  (ISO)
arsenous acid  (ISO)
artesunate  (EXP)
aspalathin  (ISO)
astaxanthin  (ISO)
atazanavir sulfate  (ISO)
atorvastatin calcium  (EXP,ISO)
ATP  (ISO)
atrazine  (ISO)
auranofin  (ISO)
azathioprine  (ISO)
baicalin  (EXP,ISO)
benazepril  (ISO)
benzalkonium chloride  (ISO)
benzo[a]pyrene  (EXP,ISO)
benzo[a]pyrene diol epoxide I  (ISO)
benzylpenicillin  (ISO)
berberine  (EXP,ISO)
Bergenin  (ISO)
Besigomsin  (ISO)
bicalutamide  (ISO)
bis(2-chloroethyl) sulfide  (ISO)
bis(2-ethylhexyl) phthalate  (EXP,ISO)
bisdemethoxycurcumin  (ISO)
Bisibuthiamine  (EXP)
bisphenol A  (EXP,ISO)
Bisphenol A diglycidyl ether  (EXP)
bisphenol F  (ISO)
boldenone  (EXP)
bortezomib  (EXP,ISO)
bosentan  (EXP)
butyric acid  (ISO)
cadmium atom  (EXP,ISO)
cadmium dichloride  (EXP,ISO)
calcitriol  (EXP)
cannabidiol  (ISO)
capsaicin  (EXP)
carbamazepine  (ISO)
carbon nanotube  (ISO)
casticin  (ISO)
catalpol  (ISO)
ceftaroline  (ISO)
cerium trichloride  (ISO)
CGP 52608  (ISO)
chaetoglobosin A  (ISO)
chenodeoxycholic acid  (ISO)
chitosan  (ISO)
chlorogenic acid  (EXP,ISO)
chloroquine  (ISO)
chlorothalonil  (ISO)
chlorpyrifos  (EXP)
cholesterol  (EXP)
choline  (ISO)
chromium atom  (ISO)
chrysin  (EXP,ISO)
cirsilineol  (ISO)
cisplatin  (EXP,ISO)
cobalt dichloride  (EXP,ISO)
copper atom  (EXP)
copper(0)  (EXP)
copper(II) sulfate  (ISO)
cordycepin  (ISO)
corticosterone  (ISO)
cortisol  (ISO)
crocin-1  (EXP)
cudratricusxanthone A  (ISO)
curcumin  (EXP,ISO)
cyclophosphamide  (ISO)
cyclosporin A  (ISO)
cyhalothrin  (EXP)
D-glucose  (EXP,ISO)
DAPT  (EXP)
daunorubicin  (ISO)
decabromodiphenyl ether  (EXP)
dehydroepiandrosterone  (EXP)
deoxycholic acid  (ISO)
deoxynivalenol  (ISO)
desferrioxamine B  (ISO)
dexamethasone  (EXP,ISO)
dextran sulfate  (ISO)
diallyl trisulfide  (ISO)
diarsenic trioxide  (ISO)
diazinon  (ISO)
dibutyl phthalate  (EXP)
dienogest  (ISO)
dihydrogen  (EXP)
dimethylarsinous acid  (ISO)
dioxygen  (EXP,ISO)
diprotium  (EXP)
dorsomorphin  (ISO)
doxorubicin  (EXP,ISO)
enalapril  (ISO)
enalaprilat dihydrate  (EXP)
erythromycin A  (ISO)
esculetin  (ISO)
ethanol  (EXP,ISO)
ethion  (ISO)
ethyl methanesulfonate  (ISO)
ethylparaben  (ISO)
eugenol  (ISO)
euxanthone  (ISO)
Fargesin  (ISO)
ferric oxide  (ISO)
ferroheme b  (ISO)
ferulic acid  (ISO)
fisetin  (ISO)
flavonoids  (EXP)
folic acid  (ISO)
formaldehyde  (EXP)
formononetin  (ISO)
fructose  (EXP,ISO)
furan  (EXP)
gadolinium trichloride  (EXP)
galactose  (EXP,ISO)
galangin  (EXP)
gallocatechin  (ISO)
gamma-hexachlorocyclohexane  (ISO)
ganglioside GM1  (EXP)
Gastrodin  (EXP)
geldanamycin  (ISO)
genistein  (ISO)
genkwanin  (ISO)
gentamycin  (EXP)
geraniol  (ISO)
Ginkgolide A  (ISO)
ginsenoside Re  (ISO)
glucose  (EXP,ISO)
glutathione  (ISO)
glyburide  (EXP)
glycerol  (EXP)
glycochenodeoxycholic acid  (ISO)
glycocholic acid  (ISO)
glycodeoxycholic acid  (ISO)
glycyrrhetinate  (ISO)
glycyrrhetinic acid  (ISO)
halothane  (ISO)
Harpagide  (ISO)
helenalin  (ISO)
heme b  (ISO)
hexadecanoic acid  (ISO)
hyaluronic acid  (ISO)
hydrogen cyanide  (ISO)
hydroquinone  (ISO)
ifosfamide  (ISO)
indometacin  (ISO)
indoprofen  (ISO)
irinotecan  (ISO)
iron(2+) sulfate (anhydrous)  (ISO)
isoamylol  (ISO)
isoprenaline  (EXP,ISO)
ivermectin  (ISO)
kaempferol 3-O-beta-D-glucosyl-(1->2)-beta-D-glucoside  (ISO)
kainic acid  (EXP)
ketamine  (ISO)
Kukoamine B  (ISO)
L-1,4-dithiothreitol  (ISO)
L-ascorbic acid  (ISO)
L-methionine  (ISO)
lactulose  (EXP)
lead diacetate  (ISO)
lead(0)  (ISO)
lidocaine  (EXP)
linsidomine  (ISO)
lipophosphoglycan  (ISO)
lipopolysaccharide  (EXP,ISO)
liquiritigenin  (EXP)
liquiritin  (EXP)
lithium chloride  (EXP)
LY294002  (ISO)
lycopene  (ISO)
magnesium dihydroxide  (ISO)
malathion  (ISO)
melatonin  (EXP,ISO)
melittin  (ISO)
melphalan  (ISO)
mesalamine  (ISO)
metformin  (EXP,ISO)
methadone  (EXP,ISO)
methamphetamine  (EXP,ISO)
methimazole  (EXP)
methotrexate  (EXP,ISO)
methyl methanesulfonate  (ISO)
methylisothiazolinone  (ISO)
Methylthiouracil  (ISO)
metronidazole  (ISO)
mirabegron  (EXP)
mirtazapine  (EXP)
monocrotaline  (EXP,ISO)
monodansylcadaverine  (ISO)
morphine  (EXP,ISO)
Morphine-3-glucuronide  (EXP,ISO)
Morroniside  (ISO)
muramyl dipeptide  (ISO)
myo-inositol hexakisphosphate  (ISO)
myrtenol  (EXP)
N-[2-(diethylamino)ethyl]-2-methoxy-5-methylsulfonylbenzamide  (EXP)
N-acetyl-L-cysteine  (ISO)
N-methyl-4-phenylpyridinium  (ISO)
N-methyl-N'-nitro-N-nitrosoguanidine  (EXP)
N-nitrosodimethylamine  (EXP)
N-Nitrosopyrrolidine  (ISO)
naloxone  (ISO)
naproxen  (EXP)
nefazodone  (ISO)
neomycin  (ISO)
nerolidol  (EXP)
nickel dichloride  (ISO)
nickel sulfate  (ISO)
nicorandil  (EXP)
nicotine  (EXP,ISO)
nitric oxide  (ISO)
Nonidet P-40  (ISO)
Nonylphenol  (EXP,ISO)
o-anisidine  (ISO)
obeticholic acid  (ISO)
omeprazole  (EXP)
oxaliplatin  (ISO)
ozone  (EXP,ISO)
paclitaxel  (ISO)
paracetamol  (EXP,ISO)
paraquat  (EXP,ISO)
PD 0325901  (ISO)
pelargonidin  (ISO)
pentachlorophenol  (ISO)
Pentoxifylline  (EXP)
perampanel  (EXP)
perfluorohexanesulfonic acid  (ISO)
perfluorononanoic acid  (ISO)
perfluorooctanoic acid  (ISO)
perindopril  (EXP)
permethrin  (ISO)
phenethyl caffeate  (ISO)
phenylmercury acetate  (ISO)
phenytoin  (ISO)
phorbol 13-acetate 12-myristate  (ISO)
phosphatidylinositol dimannoside  (ISO)
phosphoramide mustard  (EXP)
picropodophyllotoxin  (ISO)
pipoxolan  (ISO)
pirinixic acid  (ISO)
platycodin D  (EXP)
polymyxin B2  (ISO)
potassium chromate  (ISO)
potassium cyanide  (ISO)
pregnenolone 16alpha-carbonitrile  (EXP)
probenecid  (ISO)
procyanidin B1  (ISO)
progesterone  (ISO)
propofol  (ISO)
puerarin  (ISO)
Pyridostigmine bromide  (ISO)
quercetin  (EXP,ISO)
reactive oxygen species  (ISO)
resveratrol  (EXP,ISO)
rosmarinic acid  (EXP)
rotenone  (EXP)
S-allylcysteine  (ISO)
S-butyl-DL-homocysteine (S,R)-sulfoximine  (EXP,ISO)
Salvianolic acid A  (ISO)
salvianolic acid B  (EXP)
SB 431542  (ISO)
scoparone  (ISO)
scopoletin  (EXP)
sevoflurane  (EXP)
silicon dioxide  (ISO)
simvastatin  (EXP,ISO)
sodium acetate trihydrate  (ISO)
sodium arsenite  (EXP,ISO)
sodium cholate  (EXP)
sodium propionate  (ISO)
streptozocin  (EXP,ISO)
succimer  (ISO)
sulfadimethoxine  (EXP)
sulfasalazine  (ISO)
sulforaphane  (ISO)
sulfur dioxide  (ISO)
sumatriptan  (EXP)
tartrazine  (ISO)
tectorigenin  (ISO)
telmisartan  (ISO)
temozolomide  (ISO)
tert-butyl hydroperoxide  (ISO)
testosterone  (ISO)
tetrachloromethane  (EXP,ISO)
tetrachloropalladate(2-)  (ISO)
thiamine(1+) chloride  (EXP)
thioacetamide  (EXP)
thymoquinone  (EXP,ISO)
Timosaponin b ii  (ISO)
titanium atom  (EXP,ISO)
titanium dioxide  (ISO)
toluene  (ISO)
trans-anethole  (EXP)
trichloroethene  (ISO)
tropisetron  (EXP)
ubiquinone-0  (ISO)
valproic acid  (ISO)
vancomycin  (ISO)
vinclozolin  (EXP)
Vinpocetine  (EXP)
vitamin D  (ISO)
Y-27632  (ISO)
zinc atom  (EXP)
zinc oxide  (ISO)
zinc protoporphyrin  (EXP)
zinc(0)  (EXP)
zingerone  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
activation of innate immune response  (ISO)
astrocyte development  (IEA,ISO)
B cell proliferation  (ISO)
B cell proliferation involved in immune response  (IEA,ISO)
cellular response to amyloid-beta  (IEA,ISO)
cellular response to lipopolysaccharide  (IEP,ISO)
cellular response to lipoteichoic acid  (IEA,ISO)
cellular response to mechanical stimulus  (IEA,IEP,ISO)
cellular response to oxidised low-density lipoprotein particle stimulus  (IEA,ISO)
cellular response to platelet-derived growth factor stimulus  (IEA,ISO)
cellular response to retinoic acid  (IEP)
cellular response to type II interferon  (IEA,ISO)
defense response to Gram-negative bacterium  (IBA,IEA,ISO)
detection of lipopolysaccharide  (IBA,IEA,ISO,ISS)
detection of mechanical stimulus involved in sensory perception of pain  (IMP)
detection of temperature stimulus involved in sensory perception of pain  (IMP)
ERK1 and ERK2 cascade  (IEA,ISO)
gene expression  (IEA,ISO)
immunoglobulin mediated immune response  (IEP)
inflammatory response  (IBA,ISO)
innate immune response-activating signaling pathway  (IMP)
intestinal epithelial structure maintenance  (IEA,ISO)
JNK cascade  (IEA,ISO)
leukotriene metabolic process  (IDA)
lipopolysaccharide-mediated signaling pathway  (IEA,ISO)
lymphocyte proliferation  (ISO)
macrophage activation  (IEA,ISO)
MHC class II biosynthetic process  (IEA,ISO)
microglia differentiation  (IEA,ISO)
microglial cell activation  (IDA)
MyD88-dependent toll-like receptor signaling pathway  (IBA,IEA,ISO)
negative regulation of cold-induced thermogenesis  (ISO,ISS)
negative regulation of ERK1 and ERK2 cascade  (IEA,ISO)
negative regulation of interleukin-17 production  (IEA,ISO)
negative regulation of interleukin-23 production  (IEA,ISO)
negative regulation of interleukin-6 production  (IEA,ISO)
negative regulation of tumor necrosis factor production  (IEA,ISO)
negative regulation of type II interferon production  (IEA,ISO)
neurogenesis  (ISO)
nitric oxide biosynthetic process  (IEA,ISO)
nitric oxide production involved in inflammatory response  (IEA,ISO)
nucleotide-binding oligomerization domain containing 1 signaling pathway  (IEA,ISO)
nucleotide-binding oligomerization domain containing 2 signaling pathway  (IEA,ISO)
phagocytosis  (IEA,ISO)
positive regulation of apoptotic process  (IMP)
positive regulation of B cell proliferation  (IEA,ISO)
positive regulation of canonical NF-kappaB signal transduction  (IEA,ISO)
positive regulation of cellular response to macrophage colony-stimulating factor stimulus  (IEA,ISO)
positive regulation of chemokine (C-X-C motif) ligand 2 production  (IEA,ISO)
positive regulation of chemokine production  (ISO)
positive regulation of cytokine production involved in inflammatory response  (IEA,ISO)
positive regulation of DNA binding  (IMP)
positive regulation of DNA-binding transcription factor activity  (IMP)
positive regulation of ERK1 and ERK2 cascade  (IEA,ISO)
positive regulation of extrinsic apoptotic signaling pathway  (IEA,ISO)
positive regulation of gene expression  (ISO)
positive regulation of inflammatory response  (IEA,ISO)
positive regulation of interferon-alpha production  (IEA,ISO)
positive regulation of interferon-beta production  (IEA,ISO)
positive regulation of interleukin-1 beta production  (IEA,ISO,ISS)
positive regulation of interleukin-1 production  (ISO)
positive regulation of interleukin-10 production  (IEA,ISO)
positive regulation of interleukin-12 production  (IEA,ISO)
positive regulation of interleukin-6 production  (IEA,ISO)
positive regulation of interleukin-8 production  (IEA,ISO)
positive regulation of JNK cascade  (IEA,ISO)
positive regulation of lymphocyte proliferation  (ISO)
positive regulation of macrophage activation  (IEA,ISO)
positive regulation of macrophage cytokine production  (IEA,ISO)
positive regulation of matrix metallopeptidase secretion  (IEA,ISO)
positive regulation of MHC class II biosynthetic process  (IEA,ISO)
positive regulation of NF-kappaB transcription factor activity  (IMP)
positive regulation of nitric oxide biosynthetic process  (IEA,ISO)
positive regulation of nitric-oxide synthase biosynthetic process  (IEA,ISO)
positive regulation of NLRP3 inflammasome complex assembly  (IEA,ISO,ISS)
positive regulation of non-canonical NF-kappaB signal transduction  (IEA,ISO)
positive regulation of nucleotide-binding oligomerization domain containing 1 signaling pathway  (IEA,ISO)
positive regulation of nucleotide-binding oligomerization domain containing 2 signaling pathway  (IEA,ISO)
positive regulation of peptidyl-tyrosine phosphorylation  (IDA)
positive regulation of platelet activation  (IEA,ISO)
positive regulation of reactive oxygen species biosynthetic process  (IEA,ISO)
positive regulation of smooth muscle cell migration  (IEA,ISO)
positive regulation of smooth muscle cell proliferation  (IEA,ISO)
positive regulation of stress-activated MAPK cascade  (IEA,ISO)
positive regulation of transcription by RNA polymerase II  (IEA,ISO)
positive regulation of tumor necrosis factor production  (IEA,ISO)
positive regulation of type II interferon production  (IEA,ISO)
regulation of dendritic cell cytokine production  (IEA,ISO)
regulation of inflammatory response  (ISO)
regulation of tumor necrosis factor production  (IMP)
response to activity  (IEP)
response to bacterium  (ISO)
response to ethanol  (IMP)
response to fatty acid  (IDA)
response to glucocorticoid  (IEP)
response to gold nanoparticle  (IEP)
response to hypoxia  (IEP)
response to insulin  (IEP)
response to lipopolysaccharide  (IDA,IEP,ISO)
response to oxidative stress  (IMP)
response to progesterone  (IEP)
response to retinoic acid  (IEP)
response to toxic substance  (IEP)
skeletal muscle contraction  (IEP)
stress-activated MAPK cascade  (IEA,ISO)
toll-like receptor 4 signaling pathway  (IBA,IEA,ISO)
toll-like receptor signaling pathway  (IDA,ISO)
TRIF-dependent toll-like receptor signaling pathway  (IEA,ISO)
wound healing involved in inflammatory response  (IEA,ISO)

Cellular Component

Phenotype Annotations     Click to see Annotation Detail View

Mammalian Phenotype
References

References - curated
# Reference Title Reference Citation
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2. Serum Toll-Like Receptor-2, Toll-Like Receptor-4 Levels in Patients with HBeAg-Negative Chronic Viral Hepatitis B. Akbal E, etal., Viral Immunol. 2017 May;30(4):278-282. doi: 10.1089/vim.2016.0131. Epub 2017 Apr 17.
3. Gingerol protects against experimental liver fibrosis in rats via suppression of pro-inflammatory and profibrogenic mediators. Algandaby MM, etal., Naunyn Schmiedebergs Arch Pharmacol. 2016 Apr;389(4):419-28. doi: 10.1007/s00210-016-1210-1. Epub 2016 Jan 26.
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6. Lack of association between Toll-like receptor 4 gene polymorphisms and giant cell arteritis. Alvarez-Rodriguez L, etal., Rheumatology (Oxford). 2011 Sep;50(9):1562-8. doi: 10.1093/rheumatology/ker168. Epub 2011 May 17.
7. Pivotal advance: HMGB1 expression in active lesions of human and experimental multiple sclerosis. Andersson A, etal., J Leukoc Biol. 2008 Nov;84(5):1248-55. Epub 2008 Jul 21.
8. Whole-blood gene expression profiling in ankylosing spondylitis shows upregulation of toll-like receptor 4 and 5. Assassi S, etal., J Rheumatol. 2011 Jan;38(1):87-98. doi: 10.3899/jrheum.100469. Epub 2010 Oct 15.
9. Systemic Toll-like receptor stimulation suppresses experimental allergic asthma and autoimmune diabetes in NOD mice. Aumeunier A, etal., PLoS One. 2010 Jul 7;5(7):e11484.
10. Association of TLR4 polymorphisms with symptomatic respiratory syncytial virus infection in high-risk infants and young children. Awomoyi AA, etal., J Immunol. 2007 Sep 1;179(5):3171-7.
11. Toll-like receptor 4 and inducible nitric oxide synthase gene polymorphisms are associated with Type 2 diabetes. Bagarolli RA, etal., J Diabetes Complications. 2009 Apr 21.
12. TLR4 links podocytes with the innate immune system to mediate glomerular injury. Banas MC, etal., J Am Soc Nephrol. 2008 Apr;19(4):704-13. doi: 10.1681/ASN.2007040395. Epub 2008 Feb 6.
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14. Ischemia and reperfusion liver injury is reduced in the absence of Toll-like receptor 4. Ben-Ari Z, etal., Cell Physiol Biochem. 2012;30(2):489-98. doi: 10.1159/000341432. Epub 2012 Jul 13.
15. Influence of perineurial cells and Toll-like receptors 2 and 9 on Herpes simplex type 1 entry to the central nervous system in rat encephalitis. Bereczky-Veress B, etal., PLoS One. 2010 Aug 27;5(8):e12350.
16. Glial TLR4 receptor as new target to treat neuropathic pain: efficacy of a new receptor antagonist in a model of peripheral nerve injury in mice. Bettoni I, etal., Glia. 2008 Sep;56(12):1312-9. doi: 10.1002/glia.20699.
17. Involvement of TLR4/type I IL-1 receptor signaling in the induction of inflammatory mediators and cell death induced by ethanol in cultured astrocytes. Blanco AM, etal., J Immunol. 2005 Nov 15;175(10):6893-9.
18. Toll-like receptor signaling is critical for Wallerian degeneration and functional recovery after peripheral nerve injury. Boivin A, etal., J Neurosci. 2007 Nov 14;27(46):12565-76.
19. Expression of Toll-like receptors in healthy and allergic conjunctiva. Bonini S, etal., Ophthalmology. 2005 Sep;112(9):1528; discussion 1548-9.
20. Differential regulation of Toll-like receptor mRNAs in experimental murine central nervous system infections. Bottcher T, etal., Neurosci Lett. 2003 Jun 19;344(1):17-20.
21. MyD88 signaling pathway is involved in renal fibrosis by favoring a TH2 immune response and activating alternative M2 macrophages. Braga TT, etal., Mol Med. 2012 Oct 24;18:1231-9. doi: 10.2119/molmed.2012.00131.
22. TLR2 stimulation of intrinsic renal cells in the induction of immune-mediated glomerulonephritis. Brown HJ, etal., J Immunol. 2006 Aug 1;177(3):1925-31.
23. Toll-like receptor 4 gene polymorphism and early onset of diabetic retinopathy in patients with type 2 diabetes. Buraczynska M, etal., Hum Immunol. 2009 Feb;70(2):121-4. Epub 2009 Jan 7.
24. Toll-like receptor-4 genotype influences the survival of cystic fibrosis mice. Canale-Zambrano JC, etal., Am J Physiol Gastrointest Liver Physiol. 2010 Aug;299(2):G381-90. Epub 2010 Jun 3.
25. Polymorphisms in toll-like receptor genes and susceptibility to pulmonary aspergillosis. Carvalho A, etal., J Infect Dis. 2008 Feb 15;197(4):618-21.
26. Safety of the intranasal toll-like receptor 4 agonist CRX-675 in allergic rhinitis. Casale TB, etal., Ann Allergy Asthma Immunol. 2006 Oct;97(4):454-6.
27. TLR2, TLR4 and the MYD88 signaling pathway are crucial for neutrophil migration in acute kidney injury induced by sepsis. Castoldi A, etal., PLoS One. 2012;7(5):e37584. doi: 10.1371/journal.pone.0037584. Epub 2012 May 24.
28. Changes in Toll-like receptor (TLR)-2 and TLR4 expression and function but not polymorphisms are associated with acute anterior uveitis. Chang JH, etal., Invest Ophthalmol Vis Sci. 2007 Apr;48(4):1711-7.
29. TLR4- and TLR2-mediated B cell responses control the clearance of the bacterial pathogen, Leptospira interrogans. Chassin C, etal., J Immunol. 2009 Aug 15;183(4):2669-77. doi: 10.4049/jimmunol.0900506. Epub 2009 Jul 27.
30. Toll-like receptor 4 regulates heme oxygenase-1 expression after hemorrhagic shock induced acute lung injury in mice: requirement of p38 mitogen-activated protein kinase activation. Chen C, etal., Shock. 2009 May;31(5):486-92.
31. Progesterone administration modulates TLRs/NF-kappaB signaling pathway in rat brain after cortical contusion. Chen G, etal., Ann Clin Lab Sci. 2008 Winter;38(1):65-74.
32. Expression of toll-like receptor 4 in uvea-resident tissue macrophages during endotoxin-induced uveitis. Chen W, etal., Mol Vis. 2009;15:619-28. Epub 2009 Mar 30.
33. [Effect of electro-acupuncture on hepatic Toll-like receptor 4 and nuclear factor κB expressions in rats with non-alcoholic fatty liver disease]. Chen X, etal., Nan Fang Yi Ke Da Xue Xue Bao. 2014 Nov;34(11):1584-8.
34. Effect of Toll-like receptor 4 gene polymorphisms on work-related respiratory symptoms and sensitization to wheat flour in bakery workers. Cho HJ, etal., Ann Allergy Asthma Immunol. 2011 Jul;107(1):57-64. doi: 10.1016/j.anai.2011.04.003. Epub 2011 May 19.
35. Toll-like receptor polymorphisms and age-related macular degeneration: replication in three case-control samples. Cho Y, etal., Invest Ophthalmol Vis Sci. 2009 Dec;50(12):5614-8. doi: 10.1167/iovs.09-3688. Epub 2009 Jul 23.
36. Toll-like receptor 4 signalling attenuates experimental allergic conjunctivitis. Chung SH, etal., Clin Exp Immunol. 2011 May;164(2):275-81. doi: 10.1111/j.1365-2249.2011.04368.x. Epub 2011 Mar 10.
37. Pivotal role of Toll-like receptors 2 and 4, its adaptor molecule MyD88, and inflammasome complex in experimental tubule-interstitial nephritis. Correa-Costa M, etal., PLoS One. 2011;6(12):e29004. doi: 10.1371/journal.pone.0029004. Epub 2011 Dec 14.
38. A mutation in the gene TNFRSF11B encoding osteoprotegerin causes an idiopathic hyperphosphatasia phenotype. Cundy T, etal., Hum Mol Genet. 2002 Sep 1;11(18):2119-27.
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40. Adipose tissue exosome-like vesicles mediate activation of macrophage-induced insulin resistance. Deng ZB, etal., Diabetes. 2009 Aug 12.
41. Comprehensive analysis of the candidate genes CCL2, CCR2, and TLR4 in age-related macular degeneration. Despriet DD, etal., Invest Ophthalmol Vis Sci. 2008 Jan;49(1):364-71. doi: 10.1167/iovs.07-0656.
42. Increased toll-like receptor (TLR) 2 and TLR4 expression in monocytes from patients with type 1 diabetes: further evidence of a proinflammatory state. Devaraj S, etal., J Clin Endocrinol Metab. 2008 Feb;93(2):578-83. Epub 2007 Nov 20.
43. Toll-like receptor 4 regulates platelet function and contributes to coagulation abnormality and organ injury in hemorrhagic shock and resuscitation. Ding N, etal., Circ Cardiovasc Genet. 2014 Oct;7(5):615-24. doi: 10.1161/CIRCGENETICS.113.000398. Epub 2014 Jul 21.
44. Regulation by 1, 25-dihydroxy-vitamin D3 on altered TLRs expression and response to ligands of monocyte from autoimmune diabetes. Du T, etal., Clin Chim Acta. 2009 Apr;402(1-2):133-8. Epub 2009 Jan 11.
45. Modulation of monocyte hyperresponsiveness to TLR ligands by 1,25-dihydroxy-vitamin D3 from LADA and T2DM. Du T, etal., Diabetes Res Clin Pract. 2009 Feb;83(2):208-14. Epub 2008 Nov 17.
46. Toll-like receptor 4 contributes to retinal ischemia/reperfusion injury. Dvoriantchikova G, etal., Mol Vis. 2010 Sep 30;16:1907-12.
47. Significant correlation of TLR4 expression with the clinicopathological features of invasive ductal carcinoma of the breast. Ehsan N, etal., Tumour Biol. 2013 Apr;34(2):1053-9. doi: 10.1007/s13277-013-0645-y. Epub 2013 Jan 22.
48. Systemic up-regulation of TLR4 causes lipopolysaccharide-induced augmentation of nasal cytokine release in allergic rhinitis. Ekman AK, etal., Int Arch Allergy Immunol. 2012;159(1):6-14. doi: 10.1159/000335196. Epub 2012 Apr 27.
49. Cholesterol ester transfer protein, interleukin-8, peroxisome proliferator activator receptor alpha, and Toll-like receptor 4 genetic variations and risk of incident nonfatal myocardial infarction and ischemic stroke. Enquobahrie DA, etal., Am J Cardiol. 2008 Jun 15;101(12):1683-8. Epub 2008 Apr 9.
50. Single-nucleotide polymorphisms in genes encoding toll-like receptor -2, -3, -4, and -9 in case-control study with breast cancer. Etokebe GE, etal., Genet Test Mol Biomarkers. 2009 Dec;13(6):729-34. doi: 10.1089/gtmb.2009.0045.
51. A TLR4 polymorphism is associated with asthma and reduced lipopolysaccharide-induced interleukin-12(p70) responses in Swedish children. Fageras Bottcher M, etal., J Allergy Clin Immunol. 2004 Sep;114(3):561-7.
52. Regulation of Toll-like receptor 4 expression in the lung following hemorrhagic shock and lipopolysaccharide. Fan J, etal., J Immunol 2002 May 15;168(10):5252-9.
53. Toll-like receptor 4 (Tlr4) knockout rats produced by transcriptional activator-like effector nuclease (TALEN)-mediated gene inactivation. Ferguson C, etal., Alcohol. 2013 Dec;47(8):595-9. doi: 10.1016/j.alcohol.2013.09.043. Epub 2013 Oct 11.
54. Stem cell therapy for arterial restenosis: potential parameters contributing to the success of bone marrow-derived mesenchymal stromal cells. Forte A, etal., Cardiovasc Drugs Ther. 2012 Feb;26(1):9-21. doi: 10.1007/s10557-011-6359-8.
55. Up-regulation of Toll-like receptors 2, 3 and 4 in allergic rhinitis. Fransson M, etal., Respir Res. 2005 Sep 7;6:100.
56. Differential effect of insulin treatment on decreased levels of beta-defensins and Toll-like receptors in diabetic rats. Froy O, etal., Mol Immunol. 2007 Feb;44(5):796-802. Epub 2006 Jun 5.
57. Childhood allergic rhinitis, traffic-related air pollution, and variability in the GSTP1, TNF, TLR2, and TLR4 genes: results from the TAG Study. Fuertes E, etal., J Allergy Clin Immunol. 2013 Aug;132(2):342-52.e2. doi: 10.1016/j.jaci.2013.03.007. Epub 2013 Apr 30.
58. Increased Toll-like receptor 4 expression in infants with respiratory syncytial virus bronchiolitis. Gagro A, etal., Clin Exp Immunol. 2004 Feb;135(2):267-72.
59. TLR4 mediates ear