Tlr4 (toll-like receptor 4) - Rat Genome Database

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Gene: Tlr4 (toll-like receptor 4) Rattus norvegicus
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Symbol: Tlr4
Name: toll-like receptor 4
RGD ID: 3870
Description: Enables lipopolysaccharide binding activity and phosphatidylinositol 3-kinase binding activity. Involved in several processes, including cellular response to mechanical stimulus; detection of stimulus involved in sensory perception of pain; and regulation of macromolecule metabolic process. Located in cell surface. Used to study several diseases, including carotid stenosis; ileitis; neuropathy (multiple); obesity; and renal fibrosis. Biomarker of several diseases, including alcohol use disorder; familial combined hyperlipidemia; kidney failure (multiple); liver disease (multiple); and pancreatitis (multiple). Human ortholog(s) of this gene implicated in several diseases, including allergic contact dermatitis (multiple); artery disease (multiple); autoimmune disease (multiple); eye disease (multiple); and lung disease (multiple). Orthologous to human TLR4 (toll like receptor 4); PARTICIPATES IN Toll-like receptor signaling pathway; titanium dioxide nanoparticle response pathway; Chagas disease pathway; INTERACTS WITH (+)-pilocarpine; (+)-taxifolin; (S)-nicotine.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: toll4
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Allele / Splice: Tlr4m1Mcwi   Tlr4em1Geh   Tlr4em1Mcwi   Tlr4em5Mcwi  
Genetic Models: WI-Tlr4em1Geh FHH-Tlr4m1Mcwi BBDR.BBDP-(D4Mit6-D4Mit7)-Tlr4em5Mcwi SS-Tlr4em1Mcwi
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8585,161,247 - 85,174,882 (+)NCBIGRCr8
mRatBN7.2580,145,867 - 80,159,501 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl580,145,826 - 80,159,628 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx582,524,918 - 82,538,532 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0584,342,217 - 84,355,831 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0584,317,856 - 84,331,470 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0582,587,424 - 82,601,056 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl582,587,420 - 82,601,052 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0586,690,670 - 86,704,302 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4583,564,100 - 83,577,735 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1583,569,212 - 83,582,848 (+)NCBI
Celera579,045,293 - 79,058,928 (+)NCBICelera
RH 3.4 Map5643.7RGD
Cytogenetic Map5q24NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View
Acanthamoeba Keratitis  (IEP)
acne  (ISO)
Acne Conglobata  (ISO)
Acute Coronary Syndrome  (ISO)
acute kidney failure  (IDA,ISO)
Acute Liver Failure  (IEP,IMP)
Acute Lung Injury  (IEP,IMP)
acute necrotizing pancreatitis  (IEP)
acute pancreatitis  (ISO)
Acute Tubulointerstitial Nephritis  (ISO)
Acute-On-Chronic Liver Failure  (IEP)
alcohol dependence  (ISO)
alcohol use disorder  (IEP,ISO)
Alcohol-Related Disorders  (ISO)
alcoholic liver cirrhosis  (ISO)
Alcoholic Liver Diseases  (ISO)
allergic conjunctivitis  (ISO)
allergic contact dermatitis  (ISO)
allergic rhinitis  (ISO)
Alzheimer's disease  (ISO)
ankylosing spondylitis  (ISO)
anogenital venereal wart  (ISO)
anterior uveitis  (ISO)
arteriosclerosis  (ISO)
arthritis  (ISO)
asthma  (ISO)
atherosclerosis  (ISO)
atopic dermatitis  (ISO)
Bacteremia  (ISO)
Bacterial Keratitis  (ISO)
bacterial pneumonia  (ISO)
Behcet's disease  (ISO)
Binge Drinking  (ISO)
Brain Hypoxia-Ischemia  (IEP)
Brain Injuries  (IEP,ISO)
brain ischemia  (ISO)
breast cancer  (ISO)
Bronchial Hyperreactivity  (ISO)
carcinoma  (ISO)
carotid artery disease  (ISO)
carotid stenosis  (IDA)
Chemical and Drug Induced Liver Injury  (IEP)
cholesteatoma  (ISO)
cholesteatoma of middle ear  (ISO)
Chronic Hepatitis B  (ISO)
Chronic Hepatitis C  (ISO)
Chronic Intermittent Hypoxia  (IMP)
chronic obstructive pulmonary disease  (ISO)
Chronic Pain  (ISO)
Chronic Periodontitis  (ISO)
colitis  (IEP,ISO)
Colorectal Neoplasms  (ISO)
contact dermatitis  (ISO)
coronary artery disease  (ISO)
COVID-19  (ISO)
Crohn's disease  (ISO)
cutaneous leishmaniasis  (ISO)
cystic echinococcosis  (ISO)
cystic fibrosis  (ISO)
dermatomyositis  (ISO)
diabetes mellitus  (ISO)
Diabetic Foot  (ISO)
Diabetic Nephropathies  (ISO)
diabetic neuropathy  (IDA,ISO)
diabetic retinopathy  (ISO)
dry eye syndrome  (ISO)
Dysbiosis  (ISO)
end stage renal disease  (ISO)
Endotoxemia  (IDA,ISO)
Entamoebiasis  (ISO)
Eosinophilia  (ISO)
Escherichia Coli Meningitis  (ISO)
esophagus adenocarcinoma  (ISO)
essential hypertension  (ISO)
eumycotic mycetoma  (ISO)
exfoliation syndrome  (ISO)
Experimental Arthritis  (IEP)
Experimental Autoimmune Encephalomyelitis  (IEP)
Experimental Autoimmune Neuritis  (IEP)
Experimental Autoimmune Uveitis  (ISO)
Experimental Diabetes Mellitus  (IEP)
Experimental Liver Cirrhosis  (IDA,ISO)
extrahepatic cholestasis  (ISO)
eye disease  (ISO)
familial combined hyperlipidemia  (IEP,ISO)
familial Mediterranean fever  (ISO)
fetal alcohol spectrum disorder  (ISO)
Fever  (IEP)
Fibrosis  (ISO)
Fungal Eye Infections  (IEP)
Fungal Keratitis  (ISO)
glomerulonephritis  (ISO)
glucose intolerance  (ISO)
Hearing Loss  (ISO)
Hemorrhagic Shock  (ISO)
hepatocellular carcinoma  (ISO)
hepatorenal syndrome  (IEP)
Herpes Simplex Encephalitis  (IEP)
herpes simplex virus keratitis  (ISO)
hymenolepiasis  (IEP)
Hyperalgesia  (IMP,ISO)
Hypercholesterolemia  (ISO)
hypertension  (ISO)
Hypertriglyceridemia  (ISO)
ileitis  (IMP,ISO)
Inflammation  (ISO)
Insulin Resistance  (ISO)
invasive aspergillosis  (ISO)
Kawasaki disease  (ISO)
keratitis  (ISO)
kidney failure  (IEP,ISO)
Kidney Reperfusion Injury  (IDA,ISO)
learning disability  (ISO)
leptospirosis  (ISO)
liver cirrhosis  (IEP,IMP,ISO)
Liver Injury  (ISO)
Liver Reperfusion Injury  (IEP,ISO)
low tension glaucoma  (ISO)
lung adenocarcinoma  (ISO)
lung disease  (IDA,IEP,ISO)
Lung Injury  (ISO)
Lung Neoplasms  (ISO)
Lung Reperfusion Injury  (IEP)
Lymphatic Metastasis  (ISO)
macular degeneration  (ISO)
mastitis  (IEP)
mastoiditis  (ISO)
melanoma  (ISO)
membranoproliferative glomerulonephritis  (ISO)
meningococcal meningitis  (ISO)
metabolic dysfunction and alcohol associated liver disease  (IEP,ISO)
metabolic dysfunction-associated steatotic liver disease  (IEP,ISO)
middle cerebral artery infarction  (IEP)
multiple sclerosis  (ISO)
myocardial infarction  (ISO)
Myocardial Reperfusion Injury  (IDA,IEP)
Nasal Polyps  (ISO)
Neoplasm Invasiveness  (ISO)
Neoplasm Metastasis  (ISO)
Neuralgia  (IEP)
obesity  (IMP,ISO)
Ocular Onchocerciasis  (ISO)
Optic Nerve Injuries  (ISO)
Oral Lichen Planus  (ISO)
otitis media  (ISO)
Otitis Media with Effusion  (ISO)
Ovarian Neoplasms  (ISO)
Pain  (IMP)
Painful Neuropathy  (ISO)
pancreatitis  (IEP,ISO)
perinatal necrotizing enterocolitis  (IEP,ISO)
periodontitis  (ISO)
Plaque, Atherosclerotic  (ISO)
pleural tuberculosis  (ISO)
Pneumococcal Meningitis  (ISO)
pneumonia  (ISO)
Postoperative Cognitive Dysfunction  (IEP)
pre-eclampsia  (ISO)
primary open angle glaucoma  (ISO)
Prostatic Neoplasms  (ISO)
Pseudomonas Aeruginosa Keratitis  (ISO)
psoriasis  (ISO)
pulmonary edema  (ISO)
pulmonary emphysema  (ISO,ISS)
pulmonary fibrosis  (ISO)
pulmonary hypertension  (ISO)
pulmonary tuberculosis  (ISO)
pulpitis  (IEP)
renal fibrosis  (IMP)
Reperfusion Injury  (IEP,ISO)
respiratory allergy  (ISO)
Respiratory Sounds  (ISO)
respiratory syncytial virus infectious disease  (ISO)
Retina Reperfusion Injury  (ISO)
Rhinosinusitis  (ISO)
sciatic neuropathy  (IEP,IMP,ISO)
Seasonal Allergic Rhinitis  (ISO)
Sepsis  (IEP,ISO)
severe COVID-19  (ISO)
sinusitis  (ISO)
Spinal Cord Injuries  (ISO)
Spinal Cord Reperfusion Injury  (IMP)
sporotrichosis  (ISO)
squamous cell carcinoma  (ISO)
Stable Angina  (ISO)
steatotic liver disease  (ISO)
stomach cancer  (ISO)
Stroke  (ISO)
Subarachnoid Hemorrhage  (IEP)
suppurative otitis media  (ISO)
systemic lupus erythematosus  (ISO)
temporal arteritis  (ISO)
transient cerebral ischemia  (ISO)
Transplant Rejection  (ISO)
tuberculosis  (ISO)
tympanosclerosis  (ISO)
type 1 diabetes mellitus  (ISO)
type 2 diabetes mellitus  (IEP,ISO)
uric acid nephrolithiasis  (IEP)
urinary bladder cancer  (ISO)
urinary tract infection  (ISO)
uveitis  (IEP)
Ventricular Dysfunction, Left  (ISO)
Vibrio Vulnificus Infection  (IEP)
Viral Bronchiolitis  (ISO)
viral meningitis  (ISO)
vitiligo  (ISO)
Wallerian Degeneration  (ISO)
Weight Loss  (ISO)

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-catechin  (ISO)
(+)-epicatechin-3-O-gallate  (ISO)
(+)-pilocarpine  (EXP)
(+)-taxifolin  (EXP)
(-)-demecolcine  (ISO)
(-)-epigallocatechin 3-gallate  (ISO)
(24S)-24-hydroxycholesterol  (ISO)
(25R)-cholest-5-ene-3beta,26-diol  (ISO)
(S)-nicotine  (EXP,ISO)
1,2-dichloroethane  (ISO)
1,2-dimethylhydrazine  (ISO)
1,4-dithiothreitol  (ISO)
1,4-phenylenediamine  (ISO)
1-[(2,3,4-trimethoxyphenyl)methyl]piperazine  (ISO)
1-chloro-2,4,6-trinitrobenzene  (ISO)
1-chloro-2,4-dinitrobenzene  (ISO)
1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine  (ISO)
17beta-estradiol  (EXP,ISO)
17beta-hydroxy-5alpha-androstan-3-one  (ISO)
2,2',4,4',5,5'-hexachlorobiphenyl  (ISO)
2,2,2-trichloroethanol  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,4,6-trinitrobenzenesulfonic acid  (EXP,ISO)
2-(4-iodo-2,5-dimethoxyphenyl)-1-methylethylamine  (EXP)
2-amino-2-deoxy-D-galactopyranose  (ISO)
26-hydroxycholesterol  (ISO)
3,3',4,4',5-pentachlorobiphenyl  (ISO)
3,3',5,5'-tetrabromobisphenol A  (EXP,ISO)
3,4-dihydroxybenzoic acid  (ISO)
3,4-methylenedioxymethamphetamine  (ISO)
3,5-diethoxycarbonyl-1,4-dihydrocollidine  (ISO)
3-isobutyl-1-methyl-7H-xanthine  (ISO)
3-phenylprop-2-enal  (ISO)
4,4'-sulfonyldiphenol  (ISO)
4-hydroxy-3-[4-(2-hydroxyphenyl)phenyl]-6-oxo-7H-thieno[2,3-b]pyridine-5-carbonitrile  (ISO)
4-hydroxybenzoic acid  (ISO)
4-hydroxynon-2-enal  (ISO)
4-hydroxyphenyl retinamide  (ISO)
4-methyl-3-[[1-oxo-2-(propylamino)propyl]amino]-2-thiophenecarboxylic acid methyl ester  (ISO)
5-aza-2'-deoxycytidine  (ISO)
5-fluorouracil  (EXP)
5-methoxy-2-\{[(4-methoxy-3,5-dimethylpyridin-2-yl)methyl]sulfinyl\}-1H-benzimidazole  (EXP)
6-chloro-2,3,4,9-tetrahydro-1H-carbazole-1-carboxamide  (ISO)
6-Methoxyflavone  (ISO)
6-propyl-2-thiouracil  (EXP)
7alpha-hydroxycholesterol  (ISO)
acetamide  (EXP)
acetate ester  (ISO)
acetic acid  (EXP,ISO)
acrolein  (ISO)
acrylamide  (ISO)
adenosine  (ISO)
aflatoxin B1  (EXP,ISO)
agomelatine  (EXP)
aldehydo-D-glucose  (EXP,ISO)
all-trans-retinoic acid  (ISO)
all-trans-retinol  (ISO)
alogliptin  (EXP)
alpha-D-galactose  (EXP,ISO)
alpha-pinene  (ISO)
Alpinetin  (ISO)
Alternaramide  (ISO)
aluminium hydroxide  (ISO)
amitrole  (EXP)
ammonium chloride  (EXP)
ampicillin  (ISO)
anethole  (EXP)
antirheumatic drug  (ISO)
apigenin  (ISO)
arachidonic acid  (EXP)
arsane  (ISO)
arsenic atom  (ISO)
arsenite(3-)  (ISO)
arsenous acid  (ISO)
artesunate  (EXP)
aspalathin  (ISO)
astaxanthin  (ISO)
atazanavir sulfate  (ISO)
atorvastatin calcium  (EXP,ISO)
ATP  (ISO)
atrazine  (ISO)
auranofin  (ISO)
azathioprine  (ISO)
Azoxymethane  (ISO)
baicalin  (EXP,ISO)
benazepril  (ISO)
benzalkonium chloride  (ISO)
benzo[a]pyrene  (EXP,ISO)
benzo[a]pyrene diol epoxide I  (ISO)
benzylpenicillin  (ISO)
berberine  (EXP,ISO)
Bergenin  (ISO)
Besigomsin  (ISO)
beta-lapachone  (ISO)
bicalutamide  (ISO)
bis(2-chloroethyl) sulfide  (ISO)
bis(2-ethylhexyl) phthalate  (EXP,ISO)
bisdemethoxycurcumin  (ISO)
Bisibuthiamine  (EXP)
bisphenol A  (EXP,ISO)
Bisphenol A diglycidyl ether  (EXP)
bisphenol F  (ISO)
boldenone  (EXP)
bortezomib  (EXP,ISO)
bosentan  (EXP)
butyric acid  (ISO)
cabazitaxel  (ISO)
cadmium atom  (EXP,ISO)
cadmium dichloride  (EXP,ISO)
calcitriol  (EXP)
cannabidiol  (ISO)
capsaicin  (EXP)
carbamazepine  (ISO)
carbon nanotube  (ISO)
casticin  (ISO)
catalpol  (ISO)
ceftaroline  (ISO)
cerium trichloride  (ISO)
CGP 52608  (ISO)
chaetoglobosin A  (ISO)
chenodeoxycholic acid  (ISO)
chitosan  (ISO)
chlorogenic acid  (EXP,ISO)
chloroquine  (ISO)
chlorothalonil  (ISO)
chlorpyrifos  (EXP)
cholesterol  (EXP)
choline  (ISO)
chromium atom  (ISO)
chrysin  (EXP,ISO)
cirsilineol  (ISO)
cisplatin  (EXP,ISO)
cobalt dichloride  (EXP,ISO)
colistin  (EXP)
copper atom  (EXP)
copper(0)  (EXP)
copper(II) sulfate  (ISO)
cordycepin  (EXP,ISO)
corticosterone  (ISO)
cortisol  (ISO)
crocin-1  (EXP)
cudratricusxanthone A  (ISO)
curcumin  (EXP,ISO)
cyclophosphamide  (ISO)
cyclosporin A  (ISO)
cyhalothrin  (EXP)
D-glucose  (EXP,ISO)
D-penicillamine  (ISO)
dapagliflozin  (EXP)
DAPT  (EXP)
daunorubicin  (ISO)
decabromodiphenyl ether  (EXP)
dehydroepiandrosterone  (EXP)
deoxycholic acid  (ISO)
deoxynivalenol  (ISO)
desferrioxamine B  (ISO)
dexamethasone  (EXP,ISO)
dexmedetomidine  (ISO)
dextran sulfate  (ISO)
diallyl trisulfide  (ISO)
diarsenic trioxide  (ISO)
diazinon  (ISO)
Dibutyl phosphate  (ISO)
dibutyl phthalate  (EXP,ISO)
diclofenac  (EXP)
dienogest  (ISO)
dihydrogen  (EXP)
dimethylarsinous acid  (ISO)
dioxygen  (EXP,ISO)
diprotium  (EXP)
dorsomorphin  (ISO)
doxorubicin  (EXP,ISO)
embelin  (ISO)
enalapril  (ISO)
enalaprilat dihydrate  (EXP)
eritoran  (ISO)
erythromycin A  (ISO)
esculetin  (ISO)
ethanol  (EXP,ISO)
ethion  (ISO)
ethyl methanesulfonate  (ISO)
ethylparaben  (ISO)
eugenol  (ISO)
euxanthone  (ISO)
Evodiamine  (ISO)
famotidine  (ISO)
Fargesin  (ISO)
fenofibrate  (ISO)
ferric oxide  (ISO)
ferroheme b  (ISO)
ferulic acid  (ISO)
fisetin  (ISO)
flavonoids  (EXP)
folic acid  (ISO)
formaldehyde  (EXP)
formononetin  (ISO)
fosaprepitant  (ISO)
fructose  (EXP,ISO)
furan  (EXP)
gadolinium trichloride  (EXP)
galactose  (EXP,ISO)
galangin  (EXP)
gallocatechin  (ISO)
gamma-hexachlorocyclohexane  (ISO)
ganglioside GM1  (EXP)
Gastrodin  (EXP)
geldanamycin  (ISO)
genistein  (ISO)
genkwanin  (ISO)
gentamycin  (EXP)
geraniol  (ISO)
Ginkgolide A  (ISO)
ginsenoside Re  (ISO)
glucose  (EXP,ISO)
glutathione  (ISO)
glyburide  (EXP)
glycerol  (EXP)
glycine betaine  (EXP)
glycochenodeoxycholic acid  (ISO)
glycocholic acid  (ISO)
glycodeoxycholic acid  (ISO)
glycyrrhetinate  (ISO)
glycyrrhetinic acid  (ISO)
halothane  (ISO)
Harpagide  (ISO)
helenalin  (ISO)
heme b  (ISO)
hexadecanoic acid  (ISO)
hyaluronic acid  (ISO)
hydrogen cyanide  (ISO)
hydroquinone  (ISO)
icariin  (EXP)
ifosfamide  (ISO)
indometacin  (ISO)
indoprofen  (ISO)
irinotecan  (ISO)
iron(2+) sulfate (anhydrous)  (ISO)
isoamylol  (ISO)
isoprenaline  (EXP,ISO)
ivermectin  (ISO)
kaempferol 3-O-beta-D-glucosyl-(1->2)-beta-D-glucoside  (ISO)
kainic acid  (EXP)
ketamine  (ISO)
Kukoamine B  (ISO)
L-1,4-dithiothreitol  (ISO)
L-ascorbic acid  (ISO)
L-methionine  (ISO)
lactucin  (EXP)
lactulose  (EXP)
lead diacetate  (ISO)
lead(0)  (ISO)
levocabastine  (ISO)
lidocaine  (EXP)
linsidomine  (ISO)
lipophosphoglycan  (ISO)
lipopolysaccharide  (EXP,ISO)
liquiritigenin  (EXP)
liquiritin  (EXP)
lithium chloride  (EXP)
lupeol  (ISO)
LY294002  (ISO)
lycopene  (ISO)
magnesium dihydroxide  (ISO)
malathion  (ISO)
melatonin  (EXP,ISO)
melittin  (ISO)
melphalan  (ISO)
mesalamine  (ISO)
metformin  (EXP,ISO)
methadone  (EXP,ISO)
methamphetamine  (EXP,ISO)
methimazole  (EXP)
methotrexate  (EXP,ISO)
methyl methanesulfonate  (ISO)
methylisothiazolinone  (ISO)
Methylthiouracil  (ISO)
metronidazole  (ISO)
mirabegron  (EXP)
mirtazapine  (EXP)
MitoTEMPO  (ISO)
monocrotaline  (EXP,ISO)
monodansylcadaverine  (ISO)
morphine  (EXP,ISO)
Morphine-3-glucuronide  (EXP,ISO)
Morroniside  (ISO)
muramyl dipeptide  (ISO)
myo-inositol hexakisphosphate  (ISO)
myrtenol  (EXP)
N-[2-(diethylamino)ethyl]-2-methoxy-5-methylsulfonylbenzamide  (EXP)
N-acetyl-L-cysteine  (ISO)
N-methyl-4-phenylpyridinium  (ISO)
N-methyl-N'-nitro-N-nitrosoguanidine  (EXP)
N-nitrosodiethylamine  (EXP)
N-nitrosodimethylamine  (EXP)
N-Nitrosopyrrolidine  (ISO)
naloxone  (ISO)
naproxen  (EXP)
nefazodone  (ISO)
neomycin  (ISO)
nerolidol  (EXP)
nickel dichloride  (ISO)
nickel sulfate  (ISO)
nicorandil  (EXP)
nicotine  (EXP,ISO)
nitric oxide  (ISO)
Nonidet P-40  (ISO)
Nonylphenol  (EXP,ISO)
o-anisidine  (ISO)
obeticholic acid  (ISO)
omeprazole  (EXP)
Ondansetron  (EXP)
orlistat  (ISO)
oxaliplatin  (ISO)
oxybutynin  (ISO)
ozone  (EXP,ISO)
paclitaxel  (ISO)
paracetamol  (EXP,ISO)
paraquat  (EXP,ISO)
PD 0325901  (ISO)
pelargonidin  (ISO)
pentachlorophenol  (ISO)
Pentoxifylline  (EXP)
perampanel  (EXP)
perfluorohexanesulfonic acid  (ISO)
perfluorononanoic acid  (ISO)
perfluorooctanoic acid  (ISO)
perindopril  (EXP)
permethrin  (ISO)
phenethyl caffeate  (ISO)
phenylmercury acetate  (ISO)
phenytoin  (ISO)
phorbol 13-acetate 12-myristate  (ISO)
phosphatidylinositol dimannoside  (ISO)
phosphoramide mustard  (EXP)
picropodophyllotoxin  (ISO)
pipoxolan  (ISO)
pirfenidone  (ISO)
pirinixic acid  (ISO)
platycodin D  (EXP)
polymyxin B2  (ISO)
potassium chromate  (ISO)
potassium cyanide  (ISO)
pregnenolone 16alpha-carbonitrile  (EXP)
probenecid  (ISO)
procyanidin B1  (ISO)
progesterone  (ISO)
propofol  (ISO)
puerarin  (ISO)
Pyridostigmine bromide  (ISO)
quercetin  (EXP,ISO)
reactive oxygen species  (ISO)
resveratrol  (EXP,ISO)
rosmarinic acid  (EXP)
rotenone  (EXP)
rutin  (ISO)
S-allylcysteine  (ISO)
S-butyl-DL-homocysteine (S,R)-sulfoximine  (EXP,ISO)
Salvianolic acid A  (ISO)
salvianolic acid B  (EXP,ISO)
SB 431542  (ISO)
scoparone  (ISO)
scopoletin  (EXP)
scutellarin  (ISO)
sevoflurane  (EXP)
silicon dioxide  (ISO)
simvastatin  (EXP,ISO)
sodium acetate trihydrate  (ISO)
sodium arsenite  (EXP,ISO)
sodium cholate  (EXP)
sodium propionate  (ISO)
streptozocin  (EXP,ISO)
succimer  (ISO)
sulfadimethoxine  (EXP)
sulfasalazine  (ISO)
sulforaphane  (ISO)
sulfur dioxide  (ISO)
sumatriptan  (EXP)
tartrazine  (ISO)
tectorigenin  (ISO)
telmisartan  (ISO)
temozolomide  (ISO)
tert-butyl hydroperoxide  (ISO)
testosterone  (ISO)
tetrachloromethane  (EXP,ISO)
tetrachloropalladate(2-)  (ISO)
thiamine(1+) chloride  (EXP)
thioacetamide  (EXP)
thymoquinone  (EXP,ISO)
Timosaponin b ii  (ISO)
titanium atom  (EXP,ISO)
titanium dioxide  (ISO)
toluene  (ISO)
trans-anethole  (EXP)
trichloroethene  (ISO)
triphenyl phosphate  (ISO)
tropisetron  (EXP)
ubiquinone-0  (ISO)
valproic acid  (ISO)
vancomycin  (ISO)
vinclozolin  (EXP)
Vinpocetine  (EXP)
vitamin D  (ISO)
Y-27632  (ISO)
zearalenone  (ISO)
zinc atom  (EXP)
zinc oxide  (ISO)
zinc protoporphyrin  (EXP)
zinc(0)  (EXP)
zingerone  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
activation of innate immune response  (IEA,ISO)
astrocyte development  (IEA,ISO)
B cell proliferation  (IEA,ISO)
B cell proliferation involved in immune response  (IEA,ISO)
cellular response to amyloid-beta  (IEA,ISO)
cellular response to lipopolysaccharide  (IEA,IEP,ISO)
cellular response to lipoteichoic acid  (IEA,ISO)
cellular response to mechanical stimulus  (IEA,IEP,ISO)
cellular response to oxidised low-density lipoprotein particle stimulus  (IEA,ISO)
cellular response to platelet-derived growth factor stimulus  (IEA,ISO)
cellular response to retinoic acid  (IEP)
cellular response to type II interferon  (IEA,ISO)
defense response to bacterium  (IEA)
defense response to Gram-negative bacterium  (IBA,IEA,ISO)
detection of lipopolysaccharide  (IBA,IEA,ISO,ISS)
detection of mechanical stimulus involved in sensory perception of pain  (IMP)
detection of temperature stimulus involved in sensory perception of pain  (IMP)
ERK1 and ERK2 cascade  (IEA,ISO)
gene expression  (IEA,ISO)
I-kappaB phosphorylation  (ISO)
immune response  (IEA)
immune system process  (IEA)
immunoglobulin mediated immune response  (IEP)
inflammatory response  (IBA,IEA,ISO)
innate immune response  (IEA,ISO)
innate immune response-activating signaling pathway  (IMP)
intestinal epithelial structure maintenance  (IEA,ISO)
JNK cascade  (IEA,ISO)
leukotriene metabolic process  (IDA)
lipopolysaccharide-mediated signaling pathway  (IEA,ISO)
lymphocyte proliferation  (IEA,ISO)
macrophage activation  (IEA,ISO)
MHC class II biosynthetic process  (IEA,ISO)
microglia differentiation  (IEA,ISO)
microglial cell activation  (IDA)
MyD88-dependent toll-like receptor signaling pathway  (IBA,IEA,ISO)
negative regulation of cold-induced thermogenesis  (IEA,ISO,ISS)
negative regulation of ERK1 and ERK2 cascade  (IEA,ISO)
negative regulation of interleukin-17 production  (IEA,ISO)
negative regulation of interleukin-23 production  (IEA,ISO)
negative regulation of interleukin-6 production  (IEA,ISO)
negative regulation of tumor necrosis factor production  (IEA,ISO)
negative regulation of type II interferon production  (IEA,ISO)
neurogenesis  (IEA,ISO)
nitric oxide biosynthetic process  (IEA,ISO)
nitric oxide production involved in inflammatory response  (IEA,ISO)
nucleotide-binding oligomerization domain containing 1 signaling pathway  (IEA,ISO)
nucleotide-binding oligomerization domain containing 2 signaling pathway  (IEA,ISO)
phagocytosis  (IEA,ISO)
positive regulation of apoptotic process  (IMP)
positive regulation of B cell proliferation  (IEA,ISO)
positive regulation of canonical NF-kappaB signal transduction  (IEA,ISO)
positive regulation of cell migration  (IMP)
positive regulation of cellular response to macrophage colony-stimulating factor stimulus  (IEA,ISO)
positive regulation of chemokine (C-X-C motif) ligand 2 production  (IEA,ISO)
positive regulation of chemokine production  (IEA,ISO)
positive regulation of cytokine production involved in inflammatory response  (IEA,ISO)
positive regulation of DNA binding  (IMP)
positive regulation of DNA-binding transcription factor activity  (IMP)
positive regulation of ERK1 and ERK2 cascade  (IEA,ISO)
positive regulation of extrinsic apoptotic signaling pathway  (IEA,ISO)
positive regulation of gene expression  (IEA,ISO)
positive regulation of inflammatory response  (IEA,ISO)
positive regulation of interferon-alpha production  (IEA,ISO)
positive regulation of interferon-beta production  (IEA,ISO)
positive regulation of interleukin-1 beta production  (IEA,ISO,ISS)
positive regulation of interleukin-1 production  (IEA,ISO)
positive regulation of interleukin-10 production  (IEA,ISO)
positive regulation of interleukin-12 production  (IEA,ISO)
positive regulation of interleukin-6 production  (IEA,ISO)
positive regulation of interleukin-8 production  (IEA,ISO)
positive regulation of JNK cascade  (IEA,ISO)
positive regulation of lymphocyte proliferation  (IEA,ISO)
positive regulation of macrophage activation  (IEA,ISO)
positive regulation of macrophage cytokine production  (IEA,ISO)
positive regulation of MAP kinase activity  (ISO)
positive regulation of matrix metallopeptidase secretion  (IEA,ISO)
positive regulation of MHC class II biosynthetic process  (IEA,ISO)
positive regulation of NF-kappaB transcription factor activity  (IMP,ISO)
positive regulation of nitric oxide biosynthetic process  (IEA,ISO)
positive regulation of NLRP3 inflammasome complex assembly  (IEA,ISO,ISS)
positive regulation of non-canonical NF-kappaB signal transduction  (IEA)
positive regulation of nucleotide-binding oligomerization domain containing 1 signaling pathway  (IEA,ISO)
positive regulation of nucleotide-binding oligomerization domain containing 2 signaling pathway  (IEA,ISO)
positive regulation of peptidyl-tyrosine phosphorylation  (IDA)
positive regulation of platelet activation  (IEA,ISO)
positive regulation of reactive oxygen species biosynthetic process  (IEA,ISO)
positive regulation of smooth muscle cell migration  (IEA,ISO)
positive regulation of smooth muscle cell proliferation  (IEA,ISO)
positive regulation of stress-activated MAPK cascade  (IEA,ISO)
positive regulation of transcription by RNA polymerase II  (IEA,ISO)
positive regulation of tumor necrosis factor production  (IEA,ISO)
positive regulation of type II interferon production  (IEA,ISO)
regulation of dendritic cell cytokine production  (IEA,ISO)
regulation of inflammatory response  (IEA,ISO)
regulation of tumor necrosis factor production  (IEA,IMP)
response to activity  (IEP)
response to bacterium  (IEA,ISO)
response to ethanol  (IEP,IMP)
response to fatty acid  (IDA)
response to glucocorticoid  (IEP)
response to gold nanoparticle  (IEP)
response to hypoxia  (IEP)
response to insulin  (IEP)
response to lipopolysaccharide  (IDA,IEA,IEP,ISO)
response to oxidative stress  (IMP)
response to progesterone  (IEP)
response to retinoic acid  (IEP)
response to toxic substance  (IEP)
signal transduction  (IEA)
skeletal muscle contraction  (IEP)
stress-activated MAPK cascade  (IEA,ISO)
toll-like receptor 4 signaling pathway  (IBA,IEA,ISO)
toll-like receptor signaling pathway  (IDA,IEA,ISO)
TRIF-dependent toll-like receptor signaling pathway  (IEA,ISO)
wound healing involved in inflammatory response  (IEA,ISO)

Cellular Component

Phenotype Annotations     Click to see Annotation Detail View

Mammalian Phenotype
References

References - curated
# Reference Title Reference Citation
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2. Serum Toll-Like Receptor-2, Toll-Like Receptor-4 Levels in Patients with HBeAg-Negative Chronic Viral Hepatitis B. Akbal E, etal., Viral Immunol. 2017 May;30(4):278-282. doi: 10.1089/vim.2016.0131. Epub 2017 Apr 17.
3. Gingerol protects against experimental liver fibrosis in rats via suppression of pro-inflammatory and profibrogenic mediators. Algandaby MM, etal., Naunyn Schmiedebergs Arch Pharmacol. 2016 Apr;389(4):419-28. doi: 10.1007/s00210-016-1210-1. Epub 2016 Jan 26.
4. Protection by 20-5,14-HEDGE against surgically induced ischemia reperfusion lung injury in rats. Ali I, etal., Ann Thorac Surg. 2012 Jan;93(1):282-8. doi: 10.1016/j.athoracsur.2011.08.074. Epub 2011 Nov 23.
5. Evaluation of the polymorphism in the Toll-like receptor 4 (TLR4) genes of tympanosclerosis patients. Alpay HC, etal., Auris Nasus Larynx. 2010 Feb;37(1):29-32. doi: 10.1016/j.anl.2009.03.001. Epub 2009 Apr 26.
6. Lack of association between Toll-like receptor 4 gene polymorphisms and giant cell arteritis. Alvarez-Rodriguez L, etal., Rheumatology (Oxford). 2011 Sep;50(9):1562-8. doi: 10.1093/rheumatology/ker168. Epub 2011 May 17.
7. Pivotal advance: HMGB1 expression in active lesions of human and experimental multiple sclerosis. Andersson A, etal., J Leukoc Biol. 2008 Nov;84(5):1248-55. Epub 2008 Jul 21.
8. Thymoquinone attenuates rheumatoid arthritis by downregulating TLR2, TLR4, TNF-α, IL-1, and NFκB expression levels. Arjumand S, etal., Biomed Pharmacother. 2019 Mar;111:958-963. doi: 10.1016/j.biopha.2019.01.006. Epub 2019 Jan 9.
9. Whole-blood gene expression profiling in ankylosing spondylitis shows upregulation of toll-like receptor 4 and 5. Assassi S, etal., J Rheumatol. 2011 Jan;38(1):87-98. doi: 10.3899/jrheum.100469. Epub 2010 Oct 15.
10. Systemic Toll-like receptor stimulation suppresses experimental allergic asthma and autoimmune diabetes in NOD mice. Aumeunier A, etal., PLoS One. 2010 Jul 7;5(7):e11484.
11. Association of TLR4 polymorphisms with symptomatic respiratory syncytial virus infection in high-risk infants and young children. Awomoyi AA, etal., J Immunol. 2007 Sep 1;179(5):3171-7.
12. Toll-like receptor 4 and inducible nitric oxide synthase gene polymorphisms are associated with Type 2 diabetes. Bagarolli RA, etal., J Diabetes Complications. 2009 Apr 21.
13. TLR2 and TLR4 Expression and Inflammatory Cytokines are Altered in the Airway Epithelium of Those with Alcohol Use Disorders. Bailey KL, etal., Alcohol Clin Exp Res. 2015 Sep;39(9):1691-7. doi: 10.1111/acer.12803. Epub 2015 Jul 24.
14. TLR4 links podocytes with the innate immune system to mediate glomerular injury. Banas MC, etal., J Am Soc Nephrol. 2008 Apr;19(4):704-13. doi: 10.1681/ASN.2007040395. Epub 2008 Feb 6.
15. Toll-like-receptor gene polymorphisms in a Tunisian population with Behcet's disease. Ben Dhifallah I, etal., Clin Exp Rheumatol. 2009 Mar-Apr;27(2 Suppl 53):S58-62.
16. Ischemia and reperfusion liver injury is reduced in the absence of Toll-like receptor 4. Ben-Ari Z, etal., Cell Physiol Biochem. 2012;30(2):489-98. doi: 10.1159/000341432. Epub 2012 Jul 13.
17. Influence of perineurial cells and Toll-like receptors 2 and 9 on Herpes simplex type 1 entry to the central nervous system in rat encephalitis. Bereczky-Veress B, etal., PLoS One. 2010 Aug 27;5(8):e12350.
18. Glial TLR4 receptor as new target to treat neuropathic pain: efficacy of a new receptor antagonist in a model of peripheral nerve injury in mice. Bettoni I, etal., Glia. 2008 Sep;56(12):1312-9. doi: 10.1002/glia.20699.
19. Involvement of TLR4/type I IL-1 receptor signaling in the induction of inflammatory mediators and cell death induced by ethanol in cultured astrocytes. Blanco AM, etal., J Immunol. 2005 Nov 15;175(10):6893-9.
20. Toll-like receptor signaling is critical for Wallerian degeneration and functional recovery after peripheral nerve injury. Boivin A, etal., J Neurosci. 2007 Nov 14;27(46):12565-76.
21. Expression of Toll-like receptors in healthy and allergic conjunctiva. Bonini S, etal., Ophthalmology. 2005 Sep;112(9):1528; discussion 1548-9.
22. Differential regulation of Toll-like receptor mRNAs in experimental murine central nervous system infections. Bottcher T, etal., Neurosci Lett. 2003 Jun 19;344(1):17-20.
23. MyD88 signaling pathway is involved in renal fibrosis by favoring a TH2 immune response and activating alternative M2 macrophages. Braga TT, etal., Mol Med. 2012 Oct 24;18:1231-9. doi: 10.2119/molmed.2012.00131.
24. TLR2 stimulation of intrinsic renal cells in the induction of immune-mediated glomerulonephritis. Brown HJ, etal., J Immunol. 2006 Aug 1;177(3):1925-31.
25. Toll-like receptor 4 gene polymorphism and early onset of diabetic retinopathy in patients with type 2 diabetes. Buraczynska M, etal., Hum Immunol. 2009 Feb;70(2):121-4. Epub 2009 Jan 7.
26. Toll-like receptor-4 genotype influences the survival of cystic fibrosis mice. Canale-Zambrano JC, etal., Am J Physiol Gastrointest Liver Physiol. 2010 Aug;299(2):G381-90. Epub 2010 Jun 3.
27. Polymorphisms in toll-like receptor genes and susceptibility to pulmonary aspergillosis. Carvalho A, etal., J Infect Dis. 2008 Feb 15;197(4):618-21.
28. Safety of the intranasal toll-like receptor 4 agonist CRX-675 in allergic rhinitis. Casale TB, etal., Ann Allergy Asthma Immunol. 2006 Oct;97(4):454-6.
29. TLR2, TLR4 and the MYD88 signaling pathway are crucial for neutrophil migration in acute kidney injury induced by sepsis. Castoldi A, etal., PLoS One. 2012;7(5):e37584. doi: 10.1371/journal.pone.0037584. Epub 2012 May 24.
30. Changes in Toll-like receptor (TLR)-2 and TLR4 expression and function but not polymorphisms are associated with acute anterior uveitis. Chang JH, etal., Invest Ophthalmol Vis Sci. 2007 Apr;48(4):1711-7.
31. TLR4- and TLR2-mediated B cell responses control the clearance of the bacterial pathogen, Leptospira interrogans. Chassin C, etal., J Immunol. 2009 Aug 15;183(4):2669-77. doi: 10.4049/jimmunol.0900506. Epub 2009 Jul 27.
32. Toll-like receptor 4 regulates heme oxygenase-1 expression after hemorrhagic shock induced acute lung injury in mice: requirement of p38 mitogen-activated protein kinase activation. Chen C, etal., Shock. 2009 May;31(5):486-92.
33. Progesterone administration modulates TLRs/NF-kappaB signaling pathway in rat brain after cortical contusion. Chen G, etal., Ann Clin Lab Sci. 2008 Winter;38(1):65-74.
34. Expression of toll-like receptor 4 in uvea-resident tissue macrophages during endotoxin-induced uveitis. Chen W, etal., Mol Vis. 2009;15:619-28. Epub 2009 Mar 30.
35. [Effect of electro-acupuncture on hepatic Toll-like receptor 4 and nuclear factor κB expressions in rats with non-alcoholic fatty liver disease]. Chen X, etal., Nan Fang Yi Ke Da Xue Xue Bao. 2014 Nov;34(11):1584-8.
36. [Effect of compound qingqin liquid on the expression of toll-like receptor in the renal tissue of rats with urate nephropathy]. Chen Y, etal., Zhongguo Zhong Xi Yi Jie He Za Zhi. 2014 Jun;34(6):722-7.
37. Knockdown of myeloid differentiation protein-2 reduces acute lung injury following orthotopic autologous liver transplantation in a rat model. Chi X, etal., Pulm Pharmacol Ther. 2013 Jun;26(3):380-7. doi: 10.1016/j.pupt.2013.02.001. Epub 2013 Feb 19.
38. Effect of Toll-like receptor 4 gene polymorphisms on work-related respiratory symptoms and sensitization to wheat flour in bakery workers. Cho HJ, etal., Ann Allergy Asthma Immunol. 2011 Jul;107(1):57-64. doi: 10.1016/j.anai.2011.04.003. Epub 2011 May 19.
39. Toll-like receptor polymorphisms and age-related macular degeneration: replication in three case-control samples. Cho Y, etal., Invest Ophthalmol Vis Sci. 2009 Dec;50(12):5614-8. doi: 10.1167/iovs.09-3688. Epub 2009 Jul 23.
40. Toll-like receptor 4 signalling attenuates experimental allergic conjunctivitis. Chung SH, etal., Clin Exp Immunol. 2011 May;164(2):275-81. doi: 10.1111/j.1365-2249.2011.04368.x. Epub 2011 Mar 10.
41. Pivotal role of Toll-like receptors 2 and 4, its adaptor molecule MyD88, and inflammasome complex in experimental tubule-interstitial nephritis. Correa-Costa M, etal., PLoS One. 2011;6(12):e29004. doi: 10.1371/journal.pone.0029004. Epub 2011 Dec 14.
42. High Mobility Group Box 1/Toll-like Receptor Danger Signaling Increases Brain Neuroimmune Activation in Alcohol Dependence. Crews FT, etal., Biol Psychiatry. 2012 Nov 30. pii: S0006-3223(12)00889-X. doi: 10.1016/j.biopsych.2012.09.030.
43. A mutation in the gene TNFRSF11B encoding osteoprotegerin causes an idiopathic hyperphosphatasia phenotype. Cundy T, etal., Hum Mol Genet. 2002 Sep 1;11(18):2119-27.
44. Polymorphisms of the TLR2 and TLR4 genes are associated with risk of gastric cancer in a Brazilian population. de Oliveira JG and Silva AE, World J Gastroenterol. 2012 Mar 21;18(11):1235-42. doi: 10.3748/wjg.v18.i11.1235.
45. Expression of TLR4 and TLR9 mRNA in Lewis rats with experimental allergic neuritis. Deng YN and Zhou WB, Neuroimmunomodulation. 2007;14(6):337-43. Epub 2008 Apr 23.
46. Adipose tissue exosome-like vesicles mediate activation of macrophage-induced insulin resistance. Deng ZB, etal., Diabetes. 2009 Aug 12.
47. Comprehensive analysis of the candidate genes CCL2, CCR2, and TLR4 in age-related macular degeneration. Despriet DD, etal., Invest Ophthalmol Vis Sci. 2008 Jan;49(1):364-71. doi: 10.1167/iovs.07-0656.
48. Increased toll-like receptor (TLR) 2 and TLR4 expression in monocytes from patients with type 1 diabetes: further evidence of a proinflammatory state. Devaraj S, etal., J Clin Endocrinol Metab. 2008 Feb;93(2):578-83. Epub 2007 Nov 20.
49. Toll-like receptor 4 regulates platelet function and contributes to coagulation abnormality and organ injury in hemorrhagic shock and resuscitation. Ding N, etal., Circ Cardiovasc Genet. 2014 Oct;7(5):615-24. doi: 10.1161/CIRCGENETICS.113.000398. Epub 2014 Jul 21.
50. Effects of alcohol withdrawal on monocyte subset defects in chronic alcohol users. Donnadieu-Rigole H, etal., J Leukoc Biol. 2016 Nov;100(5):1191-1199. doi: 10.1189/jlb.5A0216-060RR. Epub 2016 Jun 2.
51. Regulation by 1, 25-dihydroxy-vitamin D3 on altered TLRs expression and response to ligands of monocyte from autoimmune diabetes. Du T, etal., Clin Chim Acta. 2009 Apr;402(1-2):133-8. Epub 2009 Jan 11.
52. Modulation of monocyte hyperresponsiveness to TLR ligands by 1,25-dihydroxy-vitamin D3 from LADA and T2DM. Du T, etal., Diabetes Res Clin Pract. 2009 Feb;83(2):208-14. Epub 2008 Nov 17.
53. Toll-like receptor 4 contributes to retinal ischemia/reperfusion injury. Dvoriantchikova G, etal., Mol Vis. 2010 Sep 30;16:1907-12.
54. Significant correlation of TLR4 expression with the clinicopathological features of invasive ductal carcinoma of the breast. Ehsan N, etal., Tumour Biol. 2013 Apr;34(2):1053-9. doi: 10.1007/s13277-013-0645-y. Epub 2013 Jan 22.
55. Systemic up-regulation of TLR4 causes lipopolysaccharide-induced augmentation of nasal cytokine release in allergic rhinitis. Ekman AK, etal., Int Arch Allergy Immunol. 2012;159(1):6-14. doi: 10.1159/000335196. Epub 2012 Apr 27.
56. Cholesterol ester transfer protein, interleukin-8, peroxisome proliferator activator receptor alpha, and Toll-like receptor 4 genetic variations and risk of incident nonfatal myocardial infarction and ischemic stroke. Enquobahrie DA, etal., Am J Cardiol. 2008 Jun 15;101(12):1683-8. Epub 2008 Apr 9.
57. Single-nucleotide polymorphisms in genes encoding toll-like receptor -2, -3, -4, and -9 in case-control study with breast cancer. Etokebe GE, etal., Genet Test Mol Biomarkers. 2009 Dec;13(6):729-34. doi: 10.1089/gtmb.2009.0045.
58. A TLR4 polymorphism is associated with asthma and reduced lipopolysaccharide-induced interleukin-12(p70) responses in Swedish children. Fageras Bottcher M, etal., J Allergy Clin Immunol. 2004 Sep;114(3):561-7.
59. Regulation of Toll-like receptor 4 expression in the lung following hemorrhagic shock and lipopolysaccharide. Fan J, etal., J Immunol 2002 May 15;168(10):5252-9.
60. Electroacupuncture Alleviates Postoperative Cognitive Dysfunction in Aged Rats by Inhibiting Hippocampal Neuroinflammation Activated via Microglia/TLRs Pathway. Feng PP, etal., Evid Based Complement Alternat Med. 2017;2017:6421260. doi: 10.1155/2017/6421260. Epub 2017 Jun 8.
61. Toll-like receptor 4 (Tlr4) knockout rats produced by transcriptional activator-like effector nuclease (TALEN)-mediated gene inactivation. Ferguson C, etal., Alcohol. 2013 Dec;47(8):595-9. doi: 10.1016/j.alcohol.2013.09.043. Epub 2013 Oct 11.
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63. Up-regulation of Toll-like receptors 2, 3 and 4 in allergic rhinitis. Fransson M, etal., Respir Res. 2005 Sep 7;6:100.
64. P2X7 Receptor Antagonist A804598 Inhibits Inflammation in Brain and Liver in C57BL/6J Mice Exposed to Chronic Ethanol and High Fat Diet. Freire D, etal., J Neuroimmune Pharmacol. 2019 Jun;14(2):263-277. doi: 10.1007/s11481-018-9816-3. Epub 2018 Oct 23.
65. Differential effect of insulin treatment on decreased levels of beta-defensins and Toll-like receptors in diabetic rats. Froy O, etal., Mol Immunol. 2007 Feb;44(5):796-802. Epub 2006 Jun 5.
66. Childhood allergic rhinitis, traffic-related air pollution, and variability in the GSTP1, TNF, TLR2, and TLR4 genes: results from the TAG Study. Fuertes E, etal., J Allergy Clin Immunol. 2013 Aug;132(2):342-52.e2. doi: 10.1016/j.jaci.2013.03.007. Epub 2013 Apr 30.
67. Increased Toll-like receptor 4 expression in infants with respiratory syncytial virus bronchiolitis. Gagro A, etal., Clin Exp Immunol. 2004 Feb;135(2):267-72.
68. TLR4 mediates early graft failure after intraportal islet transplantation. Gao Q, etal., Am J Transplant. 2010 Jul;10(7):1588-96. doi: 10.1111/j.1600-6143.2010.03151.x.
69. [Expression of HSP60, TLR4 and NF-kappaBp65 in the peripheral blood of patients with atopic dermatitis]. Gao Y and Guo ZP, Sichuan Da Xue Xue Bao Yi Xue Ban. 2009 Jul;40(4):655-7.
70. TLR4 is necessary for hyaluronan-mediated airway hyperresponsiveness after ozone inhalation. Garantziotis S, etal., Am J Respir Crit Care Med. 2010 Apr 1;181(7):666-75. Epub 2009 Dec 10.
71. Increased gene expression of Toll-like receptor 4 on peripheral blood mononuclear cells in patients with psoriasis. Garcia-Rodriguez S, etal., J Eur Acad Dermatol Venereol. 2013 Feb;27(2):242-50.
72. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
73. A multi-centre study of candidate genes for wheeze and allergy: the International Study of Asthma and Allergies in Childhood Phase 2. Genuneit J, etal., Clin Exp Allergy. 2009 Dec;39(12):1875-88.
74. Hypertensive rats are susceptible to TLR4-mediated signaling following exposure to combustion source particulate matter. Gilmour PS, etal., Inhal Toxicol. 2004;16 Suppl 1:5-18.
75. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
76. Single nucleotide polymorphisms of toll-like receptor-4 protect against acne conglobata. Grech I, etal., J Eur Acad Dermatol Venereol. 2012 Dec;26(12):1538-43. doi: 10.1111/j.1468-3083.2011.04338.x. Epub 2011 Nov 16.
77. Retinoic acid attenuates lipopolysaccharide-induced inflammatory responses by suppressing TLR4/NF-kappaB expression in rat mammary tissue. Gu B, etal., Int Immunopharmacol. 2010 Jul;10(7):799-805. doi: 10.1016/j.intimp.2010.04.022. Epub 2010 May 10.
78. Combinations of TLR and NOD2 ligands stimulate rat microglial P2X4R expression. Guo LH, etal., Biochem Biophys Res Commun. 2006 Oct 27;349(3):1156-62. Epub 2006 Sep 1.
79. Differential liver sensitization to toll-like receptor pathways in mice with alcoholic fatty liver. Gustot T, etal., Hepatology. 2006 May;43(5):989-1000. doi: 10.1002/hep.21138.
80. Neutrophil TLR4 expression is reduced in the airways of infants with severe bronchiolitis. Halfhide CP, etal., Thorax. 2009 Sep;64(9):798-805. Epub 2009 Jun 3.
81. House dust mite allergen induces asthma via Toll-like receptor 4 triggering of airway structural cells. Hammad H, etal., Nat Med. 2009 Apr;15(4):410-6. Epub 2009 Mar 29.
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83. Toll-like receptor-mediated tyrosine phosphorylation of paxillin via MyD88-dependent and -independent pathways. Hazeki K, etal., Eur J Immunol 2003 Mar;33(3):740-7.
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131. TLR2 and TLR4 polymorphisms are not associated with acne vulgaris. Koreck A, etal., Dermatology. 2006;213(3):267-9.
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144. Modulating Toll-like receptor mediated signaling by (1-->3)-beta-D-glucan rapidly induces cardioprotection. Li C, etal., Cardiovasc Res 2004 Feb 15;61(3):538-47.
145. Short ragweed pollen triggers allergic inflammation through Toll-like receptor 4-dependent thymic stromal lymphopoietin/OX40 ligand/OX40 signaling pathways. Li DQ, etal., J Allergy Clin Immunol. 2011 Dec;128(6):1318-1325.e2. doi: 10.1016/j.jaci.2011.06.041. Epub 2011 Aug 6.
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148. rhHMGB1 drives osteoblast migration in a TLR2/TLR4- and NF-kappaB-dependent manner. Li MJ, etal., Biosci Rep. 2016 Jan 7;36(1):e00300. doi: 10.1042/BSR20150239.
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179. In situ TLR2 and TLR4 expression in a murine model of mycetoma caused by Nocardia brasiliensis. Millan-Chiu BE, etal., FEMS Immunol Med Microbiol. 2011 Apr;61(3):278-87. doi: 10.1111/j.1574-695X.2010.00775.x. Epub 2011 Jan 31.
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182. Dysregulated Toll-like receptor expression and signaling in bone marrow-derived macrophages at the onset of diabetes in the non-obese diabetic mouse. Mohammad MK, etal., Int Immunol. 2006 Jul;18(7):1101-13. Epub 2006 May 25.
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211. GOA pipeline RGD automated data pipeline
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PMID:25404055   PMID:25446875   PMID:25448126   PMID:25459886   PMID:25465639   PMID:25497689   PMID:25498891   PMID:25545945   PMID:25567426   PMID:25592618   PMID:25600901   PMID:25619390  
PMID:25652858   PMID:25695672   PMID:25732086   PMID:25738964   PMID:25772012   PMID:25780291   PMID:25783987   PMID:25810567   PMID:25811788   PMID:25821307   PMID:25826492   PMID:25853857  
PMID:25880347   PMID:25895164   PMID:25931256   PMID:25978623   PMID:25979559   PMID:25986658   PMID:26033363   PMID:26056446   PMID:26065826   PMID:26085359   PMID:26116862   PMID:26119193  
PMID:26229403   PMID:26279421   PMID:26290459   PMID:26312770   PMID:26390417   PMID:26434622   PMID:26436391   PMID:26465095   PMID:26477505   PMID:26510582   PMID:26556957   PMID:26585410  
PMID:26617842   PMID:26637556   PMID:26657742   PMID:26699475   PMID:26707779   PMID:26770978   PMID:26802935   PMID:26806574   PMID:26859874   PMID:26895894   PMID:26899371   PMID:26962463  
PMID:26966782   PMID:27031871   PMID:27057550   PMID:27107073   PMID:27107801   PMID:27187237   PMID:27193049   PMID:27279424   PMID:27318790   PMID:27412936   PMID:27413256   PMID:27431018  
PMID:27494109   PMID:27506813   PMID:27519154   PMID:27538408   PMID:27539497   PMID:27590301   PMID:27665434   PMID:27681173   PMID:27714571   PMID:27756052   PMID:27776340   PMID:27916733  
PMID:27922677   PMID:27956802   PMID:27981756   PMID:27986929   PMID:28033732   PMID:28096568   PMID:28098138   PMID:28272417   PMID:28291959   PMID:28306133   PMID:28359050   PMID:28410596  
PMID:28412141   PMID:28432060   PMID:28525945   PMID:28542370   PMID:28547529   PMID:28623271   PMID:28690033   PMID:28692063   PMID:28692940   PMID:28714001   PMID:28753906   PMID:28771774  
PMID:28808786   PMID:28827130   PMID:28855278   PMID:28946139   PMID:28978536   PMID:29039447   PMID:29113143   PMID:29115455   PMID:29142263   PMID:29193143   PMID:29215742   PMID:29222622  
PMID:29281615   PMID:29304519   PMID:29309503   PMID:29359143   PMID:29488614   PMID:29508184   PMID:29510084   PMID:29511370   PMID:29524303   PMID:29532872   PMID:29536648   PMID:29589070  
PMID:29627845   PMID:29656686   PMID:29682548   PMID:29749502   PMID:29845266   PMID:29845292   PMID:29907783   PMID:29940584   PMID:29944647   PMID:30031930   PMID:30032721   PMID:30046125  
PMID:30143913   PMID:30195636   PMID:30221655   PMID:30292407   PMID:30293084   PMID:30321456   PMID:30541949   PMID:30610955   PMID:30718548   PMID:30793463   PMID:30883606   PMID:30901719  
PMID:30953818   PMID:30978539   PMID:30980393   PMID:31002842   PMID:31096078   PMID:31173204   PMID:31220774   PMID:31256136   PMID:31288981   PMID:31318049   PMID:31376096   PMID:31391320  
PMID:31432123   PMID:31444671   PMID:31595494   PMID:31598849   PMID:31678414   PMID:31781182   PMID:31801411   PMID:31939007   PMID:31998444   PMID:32003057   PMID:32031699   PMID:32084554  
PMID:32124969   PMID:32160960   PMID:32214070   PMID:32240615   PMID:32259563   PMID:32270948   PMID:32396274   PMID:32667865   PMID:32777313   PMID:32865657   PMID:32926510   PMID:33039977  
PMID:33081813   PMID:33098506   PMID:33159115   PMID:33181267   PMID:33236160   PMID:33287126   PMID:33290148   PMID:33378037   PMID:33381567   PMID:33383282   PMID:33583793   PMID:33629321  
PMID:33629328   PMID:33730389   PMID:33744886   PMID:33855084   PMID:33900898   PMID:33909363   PMID:33962830   PMID:34032546   PMID:34051593   PMID:34142718   PMID:34260072   PMID:34296787  
PMID:34343528   PMID:34369678   PMID:34411492   PMID:34491653   PMID:34507068   PMID:34610358   PMID:34610452   PMID:34676874   PMID:34719837   PMID:34780278   PMID:34929310   PMID:34955133  
PMID:34964444   PMID:35070875   PMID:35163308   PMID:35217365   PMID:35294724   PMID:35322444   PMID:35609523   PMID:35757501   PMID:35820449   PMID:35860690   PMID:35865531   PMID:36073211  
PMID:36360622   PMID:36634215   PMID:36750423   PMID:36879557   PMID:36916435   PMID:37169474   PMID:37413932   PMID:37424158   PMID:37730152   PMID:37846082   PMID:37884783   PMID:37914064  
PMID:37976699   PMID:38095803   PMID:38195088   PMID:38299431   PMID:38403153   PMID:38788361   PMID:38850784  


Genomics

Comparative Map Data
Tlr4
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8585,161,247 - 85,174,882 (+)NCBIGRCr8
mRatBN7.2580,145,867 - 80,159,501 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl580,145,826 - 80,159,628 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx582,524,918 - 82,538,532 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0584,342,217 - 84,355,831 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0584,317,856 - 84,331,470 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0582,587,424 - 82,601,056 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl582,587,420 - 82,601,052 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0586,690,670 - 86,704,302 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4583,564,100 - 83,577,735 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1583,569,212 - 83,582,848 (+)NCBI
Celera579,045,293 - 79,058,928 (+)NCBICelera
RH 3.4 Map5643.7RGD
Cytogenetic Map5q24NCBI
TLR4
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh389117,704,403 - 117,724,735 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl9117,704,175 - 117,724,735 (+)EnsemblGRCh38hg38GRCh38
GRCh379120,466,681 - 120,487,013 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 369119,506,431 - 119,519,589 (+)NCBINCBI36Build 36hg18NCBI36
Build 349117,546,137 - 117,556,781NCBI
Celera991,114,228 - 91,127,535 (+)NCBICelera
Cytogenetic Map9q33.1NCBI
HuRef990,084,535 - 90,097,850 (+)NCBIHuRef
CHM1_19120,614,005 - 120,627,323 (+)NCBICHM1_1
T2T-CHM13v2.09129,898,286 - 129,918,621 (+)NCBIT2T-CHM13v2.0
Tlr4
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39466,745,788 - 66,765,338 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl466,745,821 - 66,848,521 (+)EnsemblGRCm39 Ensembl
GRCm38466,827,551 - 66,846,581 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl466,827,584 - 66,930,284 (+)EnsemblGRCm38mm10GRCm38
MGSCv37466,488,845 - 66,503,831 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36466,314,172 - 66,329,158 (+)NCBIMGSCv36mm8
Celera465,431,141 - 65,446,127 (+)NCBICelera
Cytogenetic Map4C1NCBI
cM Map434.66NCBI
Tlr4
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495541910,191,120 - 10,202,135 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495541910,190,937 - 10,201,896 (-)NCBIChiLan1.0ChiLan1.0
TLR4
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21121,637,696 - 21,650,558 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1921,630,343 - 21,652,922 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0988,827,495 - 88,840,458 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.19117,180,250 - 117,193,510 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl9117,180,550 - 117,190,711 (+)Ensemblpanpan1.1panPan2
TLR4
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11171,356,390 - 71,367,166 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1171,356,390 - 71,367,165 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1169,768,502 - 69,779,281 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01172,483,514 - 72,494,289 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1172,483,210 - 72,494,579 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11171,012,889 - 71,023,665 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01171,034,981 - 71,045,756 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01171,767,611 - 71,778,394 (+)NCBIUU_Cfam_GSD_1.0
Tlr4
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024404947186,750,688 - 186,763,650 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049364876,518,441 - 6,533,095 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049364876,519,140 - 6,532,018 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
TLR4
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1258,044,610 - 258,058,970 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11258,044,610 - 258,054,641 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21289,775,816 - 289,785,847 (+)NCBISscrofa10.2Sscrofa10.2susScr3
TLR4
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11221,873,762 - 21,885,562 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1221,871,773 - 21,885,515 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366603521,002,852 - 21,019,229 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Tlr4
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462476017,598,630 - 17,609,120 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462476017,596,516 - 17,608,955 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Tlr4
75 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:75
Count of miRNA genes:65
Interacting mature miRNAs:73
Transcripts:ENSRNOT00000014020
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1300115Hrtrt7Heart rate QTL 72.76heart pumping trait (VT:2000009)heart rate (CMO:0000002)54786906290099692Rat
1357396Bw44Body weight QTL 444.19body mass (VT:0001259)body weight (CMO:0000012)568984307104251008Rat
1549845Scl44Serum cholesterol level QTL 446blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)540128307148607290Rat
61380Edpm5Estrogen-dependent pituitary mass QTL 54.50.92pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)568984307104251008Rat
70212Niddm25Non-insulin dependent diabetes mellitus QTL 253.54blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)51131345958Rat
1298070Scl18Serum cholesterol level QTL 183.7blood LDL cholesterol amount (VT:0000181)calculated plasma low density lipoprotein cholesterol level (CMO:0001245)579584860124584860Rat
634305Mamtr1Mammary tumor resistance QTL 10.0001mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)512789751113558310Rat
61386Bp49Blood pressure QTL 4916.6cerebrum integrity trait (VT:0010549)brain infarction volume (CMO:0001013)56029343498603051Rat
1331801Rf33Renal function QTL 334.149kidney blood vessel physiology trait (VT:0100012)absolute change in renal vascular resistance (CMO:0001900)543726656129132602Rat
1357402Bw46Body weight QTL 464.47body mass (VT:0001259)body mass index (BMI) (CMO:0000105)568984307104251008Rat
2302381Bw84Body weight QTL 844.47body mass (VT:0001259)body mass index (BMI) (CMO:0000105)568984307104251008Rat
61393Bp7Blood pressure QTL 74.50.0001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)560293434161481680Rat
1598859Cm66Cardiac mass QTL 662heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)579584860124584860Rat
1578766Tcas11Tongue tumor susceptibility QTL 114.12tongue integrity trait (VT:0010553)number of squamous cell tumors of the tongue with diameter greater than 3 mm (CMO:0001950)546711509161317411Rat
7411561Bw134Body weight QTL 134240.001body mass (VT:0001259)body weight gain (CMO:0000420)54946360094463600Rat
2303615Vencon7Ventilatory control QTL 70.001respiration trait (VT:0001943)respiration rate (CMO:0000289)55098389595983895Rat
1576312Emca8Estrogen-induced mammary cancer QTL 84.1mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)550328551141643988Rat
1641912Alcrsp18Alcohol response QTL 18response to alcohol trait (VT:0010489)duration of loss of righting reflex (CMO:0002289)535189153141643988Rat
1576314Eutr1Estrogen induced uterine response QTL 1uterus integrity trait (VT:0010575)pyometritis severity score (CMO:0002009)52138965166875058Rat
1576317Eutr2Estrogen induced uterine response QTL 20.01uterus integrity trait (VT:0010575)pyometritis severity score (CMO:0002009)534730116104251008Rat
1598845Mcs14Mammary carcinoma susceptibility QTL 140.0001mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)57636977680813390Rat
1598846Bp293Blood pressure QTL 2933.9arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)579584860124584860Rat
7394712Emca13Estrogen-induced mammary cancer QTL 13mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)5982326699753708Rat
1331773Scl26Serum cholesterol level QTL 263.065blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)54372665686724018Rat
70189Mcs5Mammary carcinoma susceptibility QTL 510.51mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)555805606132207589Rat
1331771Rf35Renal function QTL 354.36965kidney blood vessel physiology trait (VT:0100012)absolute change in renal blood flow rate (CMO:0001168)572947086724018Rat
61359EaexExperimental allergic encephalomyelitis QTL x3nervous system integrity trait (VT:0010566)post-insult time to onset of experimental autoimmune encephalomyelitis (CMO:0001422)555715622100715622Rat
2290448Scl54Serum cholesterol level QTL 542.93blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)531663789131345958Rat
61426Scl2Serum cholesterol level QTL 27.30.001blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)559793399143070159Rat
1354598Srn6Serum renin concentration QTL 63.8blood renin amount (VT:0003349)plasma renin activity level (CMO:0000116)569540295151018848Rat
9589025Epfw7Epididymal fat weight QTL 720.660.001epididymal fat pad mass (VT:0010421)epididymal fat pad weight to body weight ratio (CMO:0000658)54946360094463600Rat
2303574Gluco42Glucose level QTL 422blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)55349671998496719Rat
2290005Mcs24Mammary carcinoma susceptibility QTL 24mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)564719390109719390Rat
1331756Rf34Renal function QTL 344.16275kidney blood vessel physiology trait (VT:0100012)absolute change in renal blood flow rate (CMO:0001168)5190450412Rat
2306971Anxrr21Anxiety related response QTL 219.47fear/anxiety-related behavior trait (VT:1000241)number of entries into a discrete space in an experimental apparatus (CMO:0000960)566174080124160948Rat
2316954Rf57Renal function QTL 570kidney glomerulus morphology trait (VT:0005325)index of glomerular damage (CMO:0001135)55979352890450144Rat
1358895Bp254Blood pressure QTL 2543.60.0003arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)558829236128034027Rat
2316959Gluco59Glucose level QTL 594.7blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)534944474113558310Rat
2312671Scl64Serum cholesterol level QTL 640.001blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)568984307104251008Rat
2316957Pur21Proteinuria QTL 216.2urine protein amount (VT:0005160)urine protein level (CMO:0000591)559793528113558156Rat

Markers in Region
PMC289161P1  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2580,158,544 - 80,158,848 (+)MAPPERmRatBN7.2
Rnor_6.0582,600,100 - 82,600,403NCBIRnor6.0
Rnor_5.0586,703,346 - 86,703,649UniSTSRnor5.0
RGSC_v3.4583,576,779 - 83,577,082UniSTSRGSC3.4
Celera579,057,972 - 79,058,275UniSTS
Cytogenetic Map5q24UniSTS
Tlr4  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2580,158,060 - 80,158,238 (+)MAPPERmRatBN7.2
Rnor_6.0582,599,616 - 82,599,793NCBIRnor6.0
Rnor_5.0586,702,862 - 86,703,039UniSTSRnor5.0
RGSC_v3.4583,576,295 - 83,576,472UniSTSRGSC3.4
Celera579,057,488 - 79,057,665UniSTS
RH 3.4 Map5643.7UniSTS
Cytogenetic Map5q24UniSTS


Genetic Models
This gene Tlr4 is modified in the following models/strains:
WI-Tlr4em1Geh     FHH-Tlr4m1Mcwi     BBDR.BBDP-(D4Mit6-D4Mit7)-Tlr4em5Mcwi     SS-Tlr4em1Mcwi    


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
nervous system
renal system
reproductive system
respiratory system
9 11 49 113 91 90 59 25 59 6 218 97 93 45 59 31

Sequence

Nucleotide Sequences
RefSeq Transcripts NM_019178 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AF057025 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH473978 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  EU929065 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ233814 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  GQ175880 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JAXUCZ010000005 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  MT730241 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  MT730242 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  MT730243 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  MT730244 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  MT730245 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  MT730246 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  MT730247 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  MT730248 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  MT730249 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  MT730250 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  MT730251 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  MT730252 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  MT730253 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  MT730254 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  MT730255 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  MT730256 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  MT730257 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  MT730258 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  MT730259 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  MT730260 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  MT730261 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  MT730262 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  MT730263 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  MT730264 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  MT730265 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  MT730266 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  MT730267 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  MT730268 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  MT730269 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  MT730270 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  MT730271 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  MT730272 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  MT730273 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  MT730274 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  MT730275 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  MT730276 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  MT730277 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  MT730278 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  MT730279 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  MT730280 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  MT730281 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  MT730282 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  MT730283 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  MT730284 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  MT730285 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  MT730286 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  MT730287 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  MT730288 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  MT730289 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  MT730290 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  MT730291 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  MT730292 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  MT730293 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  MT730294 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  MT730295 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  MT730296 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  MT730297 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  MT730298 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  MT730299 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  MT730300 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  MT730301 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  MT730302 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  MT730303 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  MT730304 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  MT730305 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  MT730306 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  MT730307 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  MT730308 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  MT730309 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  MT730310 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  MT730311 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  MT730312 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  MT730313 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  MT730314 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  MT730315 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  MT730316 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  MT730317 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  MT730318 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  MT730319 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  MT730320 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  MT730321 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  MT730322 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  MT730323 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  MT730324 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  MT730325 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  MT730326 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  MT730327 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  MT730328 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  MT730329 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  MT730330 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  MT730331 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  MT730332 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  MT730333 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  MT730334 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  MT730335 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  MT730336 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  MT730337 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  MT730338 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  MT730339 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  MT730340 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  MT730341 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  MT730342 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  MT730343 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  MT730344 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  MT730345 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  MT730346 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  MT730347 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  MT730348 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  MT730349 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  MT730350 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  MT730351 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  MT730352 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  MT730353 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  MT730354 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  PP731906 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  PP731907 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  PP731908 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  PP731909 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  PP731910 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  PP731911 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  PP731912 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  PP731913 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  PP731914 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  PP731915 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  PP731916 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  PP731917 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Ensembl Acc Id: ENSRNOT00000014020   ⟹   ENSRNOP00000014020
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl580,145,826 - 80,159,628 (+)Ensembl
Rnor_6.0 Ensembl582,587,420 - 82,601,052 (+)Ensembl
RefSeq Acc Id: NM_019178   ⟹   NP_062051
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8585,161,247 - 85,174,882 (+)NCBI
mRatBN7.2580,145,867 - 80,159,501 (+)NCBI
Rnor_6.0582,587,424 - 82,601,056 (+)NCBI
Rnor_5.0586,690,670 - 86,704,302 (+)NCBI
RGSC_v3.4583,564,100 - 83,577,735 (+)RGD
Celera579,045,293 - 79,058,928 (+)RGD
Sequence:
Protein Sequences
Protein RefSeqs NP_062051 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAC13313 (Get FASTA)   NCBI Sequence Viewer  
  ACI15385 (Get FASTA)   NCBI Sequence Viewer  
  ACS45118 (Get FASTA)   NCBI Sequence Viewer  
  EDM10505 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000014020
  ENSRNOP00000014020.2
GenBank Protein Q9QX05 (Get FASTA)   NCBI Sequence Viewer  
  QQJ42774 (Get FASTA)   NCBI Sequence Viewer  
  QQJ42775 (Get FASTA)   NCBI Sequence Viewer  
  QQJ42776 (Get FASTA)   NCBI Sequence Viewer  
  QQJ42777 (Get FASTA)   NCBI Sequence Viewer  
  QQJ42778 (Get FASTA)   NCBI Sequence Viewer  
  QQJ42779 (Get FASTA)   NCBI Sequence Viewer  
  QQJ42780 (Get FASTA)   NCBI Sequence Viewer  
  QQJ42781 (Get FASTA)   NCBI Sequence Viewer  
  QQJ42782 (Get FASTA)   NCBI Sequence Viewer  
  QQJ42783 (Get FASTA)   NCBI Sequence Viewer  
  QQJ42784 (Get FASTA)   NCBI Sequence Viewer  
  QQJ42785 (Get FASTA)   NCBI Sequence Viewer  
  QQJ42786 (Get FASTA)   NCBI Sequence Viewer  
  QQJ42787 (Get FASTA)   NCBI Sequence Viewer  
  QQJ42788 (Get FASTA)   NCBI Sequence Viewer  
  QQJ42789 (Get FASTA)   NCBI Sequence Viewer  
  QQJ42790 (Get FASTA)   NCBI Sequence Viewer  
  QQJ42791 (Get FASTA)   NCBI Sequence Viewer  
  QQJ42792 (Get FASTA)   NCBI Sequence Viewer  
  QQJ42793 (Get FASTA)   NCBI Sequence Viewer  
  QQJ42794 (Get FASTA)   NCBI Sequence Viewer  
  QQJ42795 (Get FASTA)   NCBI Sequence Viewer  
  QQJ42796 (Get FASTA)   NCBI Sequence Viewer  
  QQJ42797 (Get FASTA)   NCBI Sequence Viewer  
  QQJ42798 (Get FASTA)   NCBI Sequence Viewer  
  QQJ42799 (Get FASTA)   NCBI Sequence Viewer  
  QQJ42800 (Get FASTA)   NCBI Sequence Viewer  
  QQJ42801 (Get FASTA)   NCBI Sequence Viewer  
  QQJ42802 (Get FASTA)   NCBI Sequence Viewer  
  QQJ42803 (Get FASTA)   NCBI Sequence Viewer  
  QQJ42804 (Get FASTA)   NCBI Sequence Viewer  
  QQJ42805 (Get FASTA)   NCBI Sequence Viewer  
  QQJ42806 (Get FASTA)   NCBI Sequence Viewer  
  QQJ42807 (Get FASTA)   NCBI Sequence Viewer  
  QQJ42808 (Get FASTA)   NCBI Sequence Viewer  
  QQJ42809 (Get FASTA)   NCBI Sequence Viewer  
  QQJ42810 (Get FASTA)   NCBI Sequence Viewer  
  QQJ42811 (Get FASTA)   NCBI Sequence Viewer  
  QQJ42812 (Get FASTA)   NCBI Sequence Viewer  
  QQJ42813 (Get FASTA)   NCBI Sequence Viewer  
  QQJ42814 (Get FASTA)   NCBI Sequence Viewer  
  QQJ42815 (Get FASTA)   NCBI Sequence Viewer  
  QQJ42816 (Get FASTA)   NCBI Sequence Viewer  
  QQJ42817 (Get FASTA)   NCBI Sequence Viewer  
  QQJ42818 (Get FASTA)   NCBI Sequence Viewer  
  QQJ42819 (Get FASTA)   NCBI Sequence Viewer  
  QQJ42820 (Get FASTA)   NCBI Sequence Viewer  
  QQJ42821 (Get FASTA)   NCBI Sequence Viewer  
  QQJ42822 (Get FASTA)   NCBI Sequence Viewer  
  QQJ42823 (Get FASTA)   NCBI Sequence Viewer  
  QQJ42824 (Get FASTA)   NCBI Sequence Viewer  
  QQJ42825 (Get FASTA)   NCBI Sequence Viewer  
  QQJ42826 (Get FASTA)   NCBI Sequence Viewer  
  QQJ42827 (Get FASTA)   NCBI Sequence Viewer  
  QQJ42828 (Get FASTA)   NCBI Sequence Viewer  
  QQJ42829 (Get FASTA)   NCBI Sequence Viewer  
  QQJ42830 (Get FASTA)   NCBI Sequence Viewer  
  QQJ42831 (Get FASTA)   NCBI Sequence Viewer  
  QQJ42832 (Get FASTA)   NCBI Sequence Viewer  
  QQJ42833 (Get FASTA)   NCBI Sequence Viewer  
  QQJ42834 (Get FASTA)   NCBI Sequence Viewer  
  QQJ42835 (Get FASTA)   NCBI Sequence Viewer  
  QQJ42836 (Get FASTA)   NCBI Sequence Viewer  
  QQJ42837 (Get FASTA)   NCBI Sequence Viewer  
  QQJ42838 (Get FASTA)   NCBI Sequence Viewer  
  QQJ42839 (Get FASTA)   NCBI Sequence Viewer  
  QQJ42840 (Get FASTA)   NCBI Sequence Viewer  
  QQJ42841 (Get FASTA)   NCBI Sequence Viewer  
  QQJ42842 (Get FASTA)   NCBI Sequence Viewer  
  QQJ42843 (Get FASTA)   NCBI Sequence Viewer  
  QQJ42844 (Get FASTA)   NCBI Sequence Viewer  
  QQJ42845 (Get FASTA)   NCBI Sequence Viewer  
  QQJ42846 (Get FASTA)   NCBI Sequence Viewer  
  QQJ42847 (Get FASTA)   NCBI Sequence Viewer  
  QQJ42848 (Get FASTA)   NCBI Sequence Viewer  
  QQJ42849 (Get FASTA)   NCBI Sequence Viewer  
  QQJ42850 (Get FASTA)   NCBI Sequence Viewer  
  QQJ42851 (Get FASTA)   NCBI Sequence Viewer  
  QQJ42852 (Get FASTA)   NCBI Sequence Viewer  
  QQJ42853 (Get FASTA)   NCBI Sequence Viewer  
  QQJ42854 (Get FASTA)   NCBI Sequence Viewer  
  QQJ42855 (Get FASTA)   NCBI Sequence Viewer  
  QQJ42856 (Get FASTA)   NCBI Sequence Viewer  
  QQJ42857 (Get FASTA)   NCBI Sequence Viewer  
  QQJ42858 (Get FASTA)   NCBI Sequence Viewer  
  QQJ42859 (Get FASTA)   NCBI Sequence Viewer  
  QQJ42860 (Get FASTA)   NCBI Sequence Viewer  
  QQJ42861 (Get FASTA)   NCBI Sequence Viewer  
  QQJ42862 (Get FASTA)   NCBI Sequence Viewer  
  QQJ42863 (Get FASTA)   NCBI Sequence Viewer  
  QQJ42864 (Get FASTA)   NCBI Sequence Viewer  
  QQJ42865 (Get FASTA)   NCBI Sequence Viewer  
  QQJ42866 (Get FASTA)   NCBI Sequence Viewer  
  QQJ42867 (Get FASTA)   NCBI Sequence Viewer  
  QQJ42868 (Get FASTA)   NCBI Sequence Viewer  
  QQJ42869 (Get FASTA)   NCBI Sequence Viewer  
  QQJ42870 (Get FASTA)   NCBI Sequence Viewer  
  QQJ42871 (Get FASTA)   NCBI Sequence Viewer  
  QQJ42872 (Get FASTA)   NCBI Sequence Viewer  
  QQJ42873 (Get FASTA)   NCBI Sequence Viewer  
  QQJ42874 (Get FASTA)   NCBI Sequence Viewer  
  QQJ42875 (Get FASTA)   NCBI Sequence Viewer  
  QQJ42876 (Get FASTA)   NCBI Sequence Viewer  
  QQJ42877 (Get FASTA)   NCBI Sequence Viewer  
  QQJ42878 (Get FASTA)   NCBI Sequence Viewer  
  QQJ42879 (Get FASTA)   NCBI Sequence Viewer  
  QQJ42880 (Get FASTA)   NCBI Sequence Viewer  
  QQJ42881 (Get FASTA)   NCBI Sequence Viewer  
  QQJ42882 (Get FASTA)   NCBI Sequence Viewer  
  QQJ42883 (Get FASTA)   NCBI Sequence Viewer  
  QQJ42884 (Get FASTA)   NCBI Sequence Viewer  
  QQJ42885 (Get FASTA)   NCBI Sequence Viewer  
  QQJ42886 (Get FASTA)   NCBI Sequence Viewer  
  QQJ42887 (Get FASTA)   NCBI Sequence Viewer  
  XAF83735 (Get FASTA)   NCBI Sequence Viewer  
  XAF83736 (Get FASTA)   NCBI Sequence Viewer  
  XAF83737 (Get FASTA)   NCBI Sequence Viewer  
  XAF83738 (Get FASTA)   NCBI Sequence Viewer  
  XAF83739 (Get FASTA)   NCBI Sequence Viewer  
  XAF83740 (Get FASTA)   NCBI Sequence Viewer  
  XAF83741 (Get FASTA)   NCBI Sequence Viewer  
  XAF83742 (Get FASTA)   NCBI Sequence Viewer  
  XAF83743 (Get FASTA)   NCBI Sequence Viewer  
  XAF83744 (Get FASTA)   NCBI Sequence Viewer  
  XAF83745 (Get FASTA)   NCBI Sequence Viewer  
  XAF83746 (Get FASTA)   NCBI Sequence Viewer  
RefSeq Acc Id: NP_062051   ⟸   NM_019178
- Peptide Label: precursor
- UniProtKB: G3V7D8 (UniProtKB/TrEMBL),   A6J802 (UniProtKB/TrEMBL),   A0A8K0ZPU7 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000014020   ⟸   ENSRNOT00000014020
Protein Domains
LRRCT   TIR

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q9QX05-F1-model_v2 AlphaFold Q9QX05 1-835 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13693807
Promoter ID:EPDNEW_R4332
Type:initiation region
Name:Tlr4_1
Description:toll-like receptor 4
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0582,587,365 - 82,587,425EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:3870 AgrOrtholog
BioCyc Gene G2FUF-41034 BioCyc
Ensembl Genes ENSRNOG00000010522 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000014020 ENTREZGENE
  ENSRNOT00000014020.4 UniProtKB/TrEMBL
Gene3D-CATH 3.40.50.10140 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  3.80.10.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro Leu-rich_rpt UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Leu-rich_rpt_typical-subtyp UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  LRR_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  TIR_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Toll-like_receptor UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Toll_tir_struct_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:29260 UniProtKB/Swiss-Prot
NCBI Gene 29260 ENTREZGENE
PANTHER PTHR24365 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  TOLL-LIKE RECEPTOR 4 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam LRR_8 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  TIR UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PharmGKB TLR4 RGD
PhenoGen Tlr4 PhenoGen
PIRSF Toll-like_receptor UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE LRR UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  TIR UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
RatGTEx ENSRNOG00000010522 RatGTEx
SMART LRR_TYP UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  TIR UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP L domain-like UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SSF52200 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
TIGR TC233833
UniProt A0A8K0ZPU7 ENTREZGENE, UniProtKB/TrEMBL
  A6J802 ENTREZGENE, UniProtKB/TrEMBL
  B6DDJ8_RAT UniProtKB/TrEMBL
  C6KDV0_RAT UniProtKB/TrEMBL
  G3V7D8 ENTREZGENE, UniProtKB/TrEMBL
  Q9QX05 ENTREZGENE, UniProtKB/Swiss-Prot
  U5LJ04_RAT UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2002-06-10 Tlr4  toll-like receptor 4      Name updated 70584 APPROVED

RGD Curation Notes
Note Type Note Reference
gene_regulation mRNA expression is regulated by oxidant stress and lipopolysacchride, with oxidant stress inhibiting LPS-induced downregulation in expression 625648