Timp3 (TIMP metallopeptidase inhibitor 3) - Rat Genome Database

Send us a Message
Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   
Search RGD Grant Resources Citing RGD About Us Contact Us
Genes Variants Community Projects QTLs Strains Markers Genome Information Ontologies Cell Lines References Download Submit Data
OntoMate (Literature Search) JBrowse (Genome Browser) Synteny Browser (VCMap) Variant Visualizer Multi-Ontology Enrichment (MOET) Gene-Ortholog Location Finder (GOLF) InterViewer (Protein-Protein Interactions) PhenoMiner (Quatitative Phenotypes) Gene Annotator OLGA (Gene List Generator) AllianceMine GViewer (Genome Viewer)
Aging & Age-Related Disease Cancer & Neoplastic Disease Cardiovascular Disease Coronavirus Disease Developmental Disease Diabetes Hematologic Disease Immune & Inflammatory Disease Infectious Disease Liver Disease Neurological Disease Obesity & Metabolic Syndrome Renal Disease Respiratory Disease Sensory Organ Disease
Find Models Genetic Models Autism Models Rat PhenoMiner (Quantitative Phenotypes) Chinchilla PhenoMiner Expected Ranges (Quantitative Phenotype) PhenoMiner Term Comparison Hybrid Rat Diversity Panel Phenotypes Phenotypes in Other Animal Models Animal Husbandry Strain Medical Records Phylogenetics Strain Availability Calendar Rats 101 Submissions Photo Archive
Pathways
Rat Community Forum Directory of Rat Laboratories Video Tutorials News RGD Publications RGD Presentations Archive Nomenclature Guidelines Resource Links Laboratory Resources Employment Resources
Advanced Search (OLGA)
Gene: Timp3 (TIMP metallopeptidase inhibitor 3) Rattus norvegicus
Analyze
Symbol: Timp3
Name: TIMP metallopeptidase inhibitor 3
RGD ID: 3865
Description: Predicted to enable metalloendopeptidase inhibitor activity and zinc ion binding activity. Involved in several processes, including cellular response to peptide; mesenchymal cell differentiation involved in bone development; and negative regulation of vascular associated smooth muscle cell proliferation. Predicted to be located in basement membrane. Predicted to be active in extracellular matrix and extracellular space. Biomarker of sciatic neuropathy and type 2 diabetes mellitus. Human ortholog(s) of this gene implicated in Sorsby's fundus dystrophy; breast carcinoma; and urinary bladder cancer. Orthologous to human TIMP3 (TIMP metallopeptidase inhibitor 3); PARTICIPATES IN angiotensin II signaling pathway via AT2 receptor; INTERACTS WITH 17alpha-ethynylestradiol; 17beta-estradiol; 2,3,7,8-tetrachlorodibenzodioxine.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: metalloproteinase inhibitor 3; TIMP-3; tissue inhibitor of metalloproteinase 3; tissue inhibitor of metalloproteinase 3 (Sorsby fundus dystrophy, pseudoinflammatory); tissue inhibitor of metalloproteinases 3
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8719,408,539 - 19,459,558 (-)NCBIGRCr8
mRatBN7.2717,520,827 - 17,571,850 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl717,521,919 - 17,571,839 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx719,480,687 - 19,531,680 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0721,639,451 - 21,690,578 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0721,420,352 - 21,471,347 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0723,543,125 - 23,594,170 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl723,544,215 - 23,594,133 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0723,693,364 - 23,744,404 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4719,677,144 - 19,727,072 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1719,686,693 - 19,737,062 (-)NCBI
Celera714,761,240 - 14,810,915 (-)NCBICelera
Cytogenetic Map7q13NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(-)-epigallocatechin 3-gallate  (ISO)
(S)-nicotine  (ISO)
1,1-dichloroethene  (ISO)
1-chloro-2,4-dinitrobenzene  (ISO)
1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine  (ISO)
17alpha-ethynylestradiol  (EXP,ISO)
17beta-estradiol  (EXP,ISO)
2,2',4,4'-Tetrabromodiphenyl ether  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,4-dibromophenyl 2,4,5-tribromophenyl ether  (ISO)
2-amino-2-deoxy-D-glucopyranose  (EXP,ISO)
2-butoxyethanol  (ISO)
2-hydroxypropanoic acid  (ISO)
2-methoxyethanol  (EXP)
3,3',4,4',5-pentachlorobiphenyl  (EXP,ISO)
3-isobutyl-1-methyl-7H-xanthine  (ISO)
3-methylcholanthrene  (EXP)
4,4'-sulfonyldiphenol  (ISO)
5-aza-2'-deoxycytidine  (ISO)
5-fluorouracil  (ISO)
acetamide  (EXP)
acrolein  (ISO)
acrylamide  (EXP)
aldehydo-D-glucosamine  (EXP,ISO)
all-trans-retinoic acid  (ISO)
alpha-Zearalanol  (EXP)
ammonium chloride  (EXP)
amosite asbestos  (ISO)
ancitabine  (ISO)
aniline  (ISO)
antirheumatic drug  (ISO)
arsane  (ISO)
arsenic atom  (ISO)
arsenous acid  (ISO)
atrazine  (EXP)
Azoxymethane  (ISO)
belinostat  (ISO)
benzo[a]pyrene  (ISO)
benzo[a]pyrene diol epoxide I  (ISO)
benzo[e]pyrene  (ISO)
Benzo[k]fluoranthene  (ISO)
beta-D-glucosamine  (EXP,ISO)
bis(2-ethylhexyl) phthalate  (ISO)
bisphenol A  (EXP,ISO)
bisphenol AF  (ISO)
bisphenol F  (ISO)
cadmium atom  (EXP,ISO)
cadmium dichloride  (EXP,ISO)
calcitriol  (ISO)
candesartan  (EXP)
capsaicin  (EXP,ISO)
carbon nanotube  (ISO)
CGP 52608  (ISO)
chlorpyrifos  (ISO)
cholesterol  (ISO)
chondroitin sulfate  (ISO)
chromium atom  (ISO)
ciglitazone  (ISO)
ciguatoxin CTX1B  (ISO)
cisplatin  (ISO)
copper atom  (EXP,ISO)
copper(0)  (EXP,ISO)
copper(II) chloride  (ISO)
copper(II) sulfate  (ISO)
corosolic acid  (ISO)
coumestrol  (ISO)
Cuprizon  (EXP)
cyclosporin A  (ISO)
cytarabine  (ISO)
DDE  (ISO)
decabromodiphenyl ether  (ISO)
deoxynivalenol  (ISO)
dexamethasone  (EXP,ISO)
dextran sulfate  (ISO)
diarsenic trioxide  (ISO)
dibutyl phthalate  (EXP,ISO)
dieldrin  (EXP)
dioxygen  (EXP,ISO)
diuron  (EXP)
dorsomorphin  (ISO)
doxorubicin  (ISO)
elemental selenium  (ISO)
endosulfan  (EXP,ISO)
entinostat  (ISO)
epoxiconazole  (ISO)
ethanol  (ISO)
fenamidone  (ISO)
fenhexamid  (ISO)
floxuridine  (ISO)
folic acid  (ISO)
formaldehyde  (EXP)
gallic acid  (EXP)
genistein  (ISO)
gentamycin  (EXP)
glafenine  (EXP)
glyphosate  (ISO)
graphite  (EXP)
heparan sulfate  (ISO)
hydrogen cyanide  (ISO)
hydroquinone  (EXP)
imidacloprid  (ISO)
indometacin  (ISO)
inulin  (ISO)
isoprenaline  (EXP,ISO)
isotretinoin  (ISO)
ivermectin  (ISO)
leflunomide  (ISO)
linuron  (EXP)
malathion  (EXP)
medroxyprogesterone acetate  (ISO)
metformin  (ISO)
methapyrilene  (ISO)
methotrexate  (ISO)
methylmercury chloride  (ISO)
methylparaben  (ISO)
methylphenidate  (EXP)
N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine  (ISO)
N-acetyl-L-cysteine  (EXP)
N-nitrosodiethylamine  (EXP)
naphthalene  (ISO)
naproxen  (EXP)
nickel atom  (ISO)
nickel dichloride  (EXP)
nickel sulfate  (ISO)
nicotine  (ISO)
nitrofen  (EXP)
ochratoxin A  (EXP)
okadaic acid  (ISO)
oxaliplatin  (EXP)
paracetamol  (EXP,ISO)
paraquat  (EXP)
parathion-methyl  (EXP)
perfluorobutyric acid  (ISO)
perfluorooctane-1-sulfonic acid  (ISO)
perfluorooctanoic acid  (EXP,ISO)
Phenelzine  (ISO)
phenylmercury acetate  (ISO)
PhIP  (EXP)
pirinixic acid  (ISO)
potassium chromate  (ISO)
potassium cyanide  (ISO)
pregnenolone 16alpha-carbonitrile  (ISO)
progesterone  (EXP,ISO)
prostaglandin F2alpha  (EXP)
rac-lactic acid  (ISO)
raloxifene  (ISO)
resveratrol  (ISO)
retinyl acetate  (ISO)
rofecoxib  (ISO)
rotenone  (ISO)
Salinomycin  (ISO)
SB 431542  (ISO)
selenium atom  (ISO)
serpentine asbestos  (ISO)
silicon dioxide  (ISO)
silver atom  (ISO)
silver(0)  (ISO)
sirolimus  (ISO)
sodium arsenate  (ISO)
sodium arsenite  (ISO)
sorafenib  (ISO)
succimer  (ISO)
sulfasalazine  (ISO)
sulindac  (ISO)
sumatriptan  (EXP)
T-2 toxin  (ISO)
tamoxifen  (ISO)
tanespimycin  (ISO)
tert-butyl hydroperoxide  (ISO)
testosterone  (ISO)
testosterone enanthate  (ISO)
tetrachloroethene  (ISO)
tetrachloromethane  (EXP,ISO)
thapsigargin  (ISO)
thioacetamide  (EXP)
thiram  (ISO)
titanium dioxide  (EXP,ISO)
topotecan  (EXP)
trichloroethene  (EXP)
trichostatin A  (ISO)
triclosan  (ISO)
valproic acid  (ISO)
vancomycin  (ISO)
vinclozolin  (EXP)
vitamin E  (ISO)
vorinostat  (ISO)
zinc atom  (EXP)
zinc sulfate  (EXP)
zinc(0)  (EXP)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Tissue inhibitor of metalloproteinase-3 induces a Fas-associated death domain-dependent type II apoptotic pathway. Bond M, etal., J Biol Chem 2002 Apr 19;277(16):13787-95.
2. Cellular localization of tissue inhibitors of metalloproteinases in the rat ovary throughout pseudopregnancy. Curry TE Jr and Wheeler SE, Biol Reprod 2002 Dec;67(6):1943-51.
3. Promoter hypermethylation profile of kidney cancer. Dulaimi E, etal., Clin Cancer Res. 2004 Jun 15;10(12 Pt 1):3972-9.
4. Exercise training and return to a well-balanced diet activate the neuregulin 1/ErbB pathway in skeletal muscle of obese rats. Ennequin G, etal., J Physiol. 2015 Jun 15;593(12):2665-77. doi: 10.1113/JP270026. Epub 2015 May 14.
5. Inhibition of diabetic nephropathy by a GH antagonist: a molecular analysis. Esposito C, etal., Kidney Int. 1996 Aug;50(2):506-14.
6. Differential spatial distribution and temporal regulation of tissue inhibitor of metalloproteinase mRNA expression during rat central nervous system development. Fager N and Jaworski DM, Mech Dev. 2000 Nov;98(1-2):105-9.
7. Sorsby fundus dystrophy: reevaluation of variable expressivity in patients carrying a TIMP3 founder mutation. Felbor U, etal., Arch Ophthalmol. 1997 Dec;115(12):1569-71.
8. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
9. Thyroid hormone induces myocardial matrix degradation by activating matrix metalloproteinase-1. Ghose Roy S, etal., Matrix Biol. 2007 May;26(4):269-79. Epub 2006 Dec 29.
10. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
11. Evidence for a role of the Simian Virus 40 in human breast carcinomas. Hachana M, etal., Breast Cancer Res Treat. 2008 Jan 18;.
12. mRNA expression of matrix metalloproteases and their inhibitors differs in subtypes of renal cell carcinomas. Hagemann T, etal., Eur J Cancer. 2001 Oct;37(15):1839-46.
13. Tissue inhibitor of metalloproteinases-3 promoter methylation is an independent prognostic factor for bladder cancer. Hoque MO, etal., J Urol. 2008 Feb;179(2):743-7. Epub 2007 Dec 20.
14. Expression of matrix metalloproteinases and endogenous inhibitors within ascending aortic aneurysms of patients with Marfan syndrome. Ikonomidis JS, etal., Circulation. 2006 Jul 4;114(1 Suppl):I365-70.
15. Inhibition of microRNA-222 up-regulates TIMP3 to promotes osteogenic differentiation of MSCs from fracture rats with type 2 diabetes mellitus. Jiang C, etal., J Cell Mol Med. 2020 Jan;24(1):686-694. doi: 10.1111/jcmm.14777. Epub 2019 Nov 6.
16. Zhonghua wai ke za zhi [Chinese journal of surgery] Jiang X, etal., Zhonghua Wai Ke Za Zhi. 2000 Apr;38(4):291-3, 19.
17. RNA constitution and estrogen-responsive gene expression in the ovariectomized rat uterus. Kamata R, etal., Anal Biochem. 2005 Jun 1;341(1):131-40.
18. Prognostic relevance of uPAR-del4/5 and TIMP-3 mRNA expression levels in breast cancer. Kotzsch M, etal., Eur J Cancer. 2005 Nov;41(17):2760-8. Epub 2005 Oct 26.
19. Intracerebroventricular administration of an endothelin ETB receptor agonist increases expression of tissue inhibitor of matrix metalloproteinase-1 and -3 in rat brain. Koyama Y, etal., Neuroscience. 2007 Jul 13;147(3):620-30. Epub 2007 Jun 6.
20. Negative correlation of cytoplasm TIMP3 with miR-222 indicates a good prognosis for NSCLC. Lei Y, etal., Onco Targets Ther. 2018 Sep 6;11:5551-5557. doi: 10.2147/OTT.S172522. eCollection 2018.
21. Moderately high folic acid supplementation exacerbates experimentally induced liver fibrosis in rats. Marsillach J, etal., Exp Biol Med (Maywood). 2008 Jan;233(1):38-47.
22. Immunohistochemical changes in vulnerable rat brain regions after reversible global brain ischaemia. Martinez G, etal., J Mol Histol. 2007 Aug;38(4):295-302. Epub 2007 Jun 6.
23. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
24. Impaired regulation of the TNF-alpha converting enzyme/tissue inhibitor of metalloproteinase 3 proteolytic system in skeletal muscle of obese type 2 diabetic patients: a new mechanism of insulin resistance in humans. Monroy A, etal., Diabetologia. 2009 Jul 25.
25. Expression of tissue inhibitor of matrix metalloproteinases (TIMP)-3 protein in invasive breast carcinoma: relation to tumor phenotype and clinical outcome. Mylona E, etal., Breast Cancer Res. 2006;8(5):R57.
26. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
27. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
28. ADAM-17 and TIMP3 protein and mRNA expression in spinal cord white matter of rats with acute experimental autoimmune encephalomyelitis. Plumb J, etal., J Neuroimmunol. 2005 Jul;164(1-2):1-9.
29. GOA pipeline RGD automated data pipeline
30. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
31. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
32. Comprehensive gene review and curation RGD comprehensive gene curation
33. Identification of degradome components associated with prostate cancer progression by expression analysis of human prostatic tissues. Riddick AC, etal., Br J Cancer. 2005 Jun 20;92(12):2171-80.
34. Expression of matrix metalloproteinase-26 and tissue inhibitors of metalloproteinase-3 and -4 in normal ovary and ovarian carcinoma. Ripley D, etal., Int J Gynecol Cancer. 2006 Sep-Oct;16(5):1794-800.
35. An ATIPical family of angiotensin II AT2 receptor-interacting proteins. Rodrigues-Ferreira S and Nahmias C, Trends Endocrinol Metab. 2010 Nov;21(11):684-90.
36. Matrix metalloproteinases and their natural inhibitors in fibrovascular membranes of proliferative diabetic retinopathy. Salzmann J, etal., Br J Ophthalmol. 2000 Oct;84(10):1091-6.
37. Ectodomain shedding of neuroglycan C, a brain-specific chondroitin sulfate proteoglycan, by TIMP-2- and TIMP-3-sensitive proteolysis. Shuo T, etal., J Neurochem. 2007 Sep;102(5):1561-8. Epub 2007 May 26.
38. Age-related changes in the expression of gelatinase and tissue inhibitor of metalloproteinase genes in mandibular condylar, growth plate, and articular cartilage in rats. Takahashi I, etal., J Mol Histol. 2005 Jun;36(5):355-66. Epub 2005 Oct 6.
39. Tentative Sequence Identification Numbers Tentative Sequence Data IDs. TIGR Gene Index, Rat Data
40. Expression of matrix metalloproteinase-26 and tissue inhibitors of metalloproteinases TIMP-3 and -4 in benign endometrium and endometrial cancer. Tunuguntla R, etal., Gynecol Oncol. 2003 Jun;89(3):453-9.
41. [Effects of glutamine on matrix metalloproteinase-3 and tissue inhibitor of metalloproteinase-3 expressions in myocardium of rats with sepsis] Wang H, etal., Zhonghua Er Ke Za Zhi. 2006 Aug;44(8):587-91.
42. Assessment of gene promoter hypermethylation for detection of cervical neoplasia. Wisman GB, etal., Int J Cancer. 2006 Oct 15;119(8):1908-14.
43. Suppression subtractive hybridization identified differentially expressed genes in lung adenocarcinoma: ERGIC3 as a novel lung cancer-related gene. Wu M, etal., BMC Cancer. 2013 Feb 1;13:44. doi: 10.1186/1471-2407-13-44.
44. MicroRNA-222 Promotes the Proliferation of Pulmonary Arterial Smooth Muscle Cells by Targeting P27 and TIMP3. Xu Y, etal., Cell Physiol Biochem. 2017;43(1):282-292. doi: 10.1159/000480371. Epub 2017 Aug 30.
45. Promoter hypermethylation of multiple genes in hydatidiform mole and choriocarcinoma. Xue WC, etal., J Mol Diagn. 2004 Nov;6(4):326-34.
46. Dietary loading and aggrecanase-1/TIMP-3 expression in rat mandibular condylar cartilage. Yu D, etal., J Orofac Pain. 2007 Summer;21(3):232-8.
47. Distribution and expression of tissue inhibitors of metalloproteinase in dorsal root entry zone and dorsal column after dorsal root injury. Zhang X, etal., J Neurosci Res. 2006 Aug 1;84(2):278-90.
48. Adenovirus carrying TIMP-3: a potential tool for cervical cancer treatment. Zhang Y, etal., Gynecol Oncol. 2008 Jan;108(1):234-40. Epub 2007 Oct 31.
49. Expression of matrix metalloproteinase -2, -9 and tissue inhibitors of metalloproteinase -1, -2, -3 mRNAs in rat uterus during early pregnancy. Zhao YG, etal., Mol Reprod Dev 2002 Jun;62(2):149-58.
50. [Changes of matrix metalloproteinase 2,9 and tissue inhibitor of metalloproteinase 1, 2, 3 expression level in aged rat lung.] Zhao ZJ, etal., Beijing Da Xue Xue Bao. 2008 Feb 18;40(1):101-104.
51. MiR-21 and miR-222 inhibit apoptosis of adult dorsal root ganglion neurons by repressing TIMP3 following sciatic nerve injury. Zhou S, etal., Neurosci Lett. 2015 Jan 23;586:43-9. doi: 10.1016/j.neulet.2014.12.006. Epub 2014 Dec 4.
Additional References at PubMed
PMID:8654952   PMID:11869290   PMID:12477932   PMID:12950084   PMID:15052653   PMID:18383040   PMID:18636553   PMID:18993041   PMID:19389837   PMID:20551380   PMID:21630459   PMID:23256480  
PMID:23376485   PMID:24006456   PMID:24560960   PMID:24727088   PMID:24812324   PMID:25028660   PMID:25245272   PMID:26686417   PMID:27068509   PMID:27339256   PMID:27559042   PMID:28230313  
PMID:29742504   PMID:31161659   PMID:31922222   PMID:32432759   PMID:32648125   PMID:38824271  


Genomics

Comparative Map Data
Timp3
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8719,408,539 - 19,459,558 (-)NCBIGRCr8
mRatBN7.2717,520,827 - 17,571,850 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl717,521,919 - 17,571,839 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx719,480,687 - 19,531,680 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0721,639,451 - 21,690,578 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0721,420,352 - 21,471,347 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0723,543,125 - 23,594,170 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl723,544,215 - 23,594,133 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0723,693,364 - 23,744,404 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4719,677,144 - 19,727,072 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1719,686,693 - 19,737,062 (-)NCBI
Celera714,761,240 - 14,810,915 (-)NCBICelera
Cytogenetic Map7q13NCBI
TIMP3
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh382232,801,705 - 32,863,041 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl2232,801,705 - 32,863,041 (+)EnsemblGRCh38hg38GRCh38
GRCh372233,197,691 - 33,259,028 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 362231,526,802 - 31,589,028 (+)NCBINCBI36Build 36hg18NCBI36
Build 342231,521,361 - 31,583,581NCBI
Celera2216,999,013 - 17,061,296 (+)NCBICelera
Cytogenetic Map22q12.3ENTREZGENE
HuRef2216,154,700 - 16,216,984 (+)NCBIHuRef
CHM1_12233,156,307 - 33,218,500 (+)NCBICHM1_1
T2T-CHM13v2.02233,266,136 - 33,327,517 (+)NCBIT2T-CHM13v2.0
Timp3
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391086,136,276 - 86,185,369 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1086,136,236 - 86,185,370 (+)EnsemblGRCm39 Ensembl
GRCm381086,300,412 - 86,349,505 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1086,300,372 - 86,349,506 (+)EnsemblGRCm38mm10GRCm38
MGSCv371085,763,157 - 85,812,250 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361085,730,336 - 85,779,305 (+)NCBIMGSCv36mm8
Celera1088,278,411 - 88,327,541 (+)NCBICelera
Cytogenetic Map10C1NCBI
cM Map1042.83NCBI
Timp3
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495540541,613,966 - 41,655,813 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495540541,613,976 - 41,655,813 (+)NCBIChiLan1.0ChiLan1.0
TIMP3
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v22342,741,534 - 42,803,142 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan12245,441,873 - 45,503,391 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v02213,811,297 - 13,872,799 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.12231,662,567 - 31,721,500 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl2231,662,562 - 31,723,964 (+)Ensemblpanpan1.1panPan2
TIMP3
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11030,627,154 - 30,681,520 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1030,627,154 - 30,694,288 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1030,610,166 - 30,664,261 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01031,469,330 - 31,523,514 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1031,465,801 - 31,536,528 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11031,209,878 - 31,264,020 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01031,499,587 - 31,553,699 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01031,684,823 - 31,738,972 (-)NCBIUU_Cfam_GSD_1.0
Timp3
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440494513,986,214 - 14,035,739 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049364926,996,613 - 7,046,190 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049364926,996,627 - 7,046,137 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
TIMP3
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl512,185,818 - 12,242,581 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1512,185,816 - 12,242,599 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2511,962,119 - 12,019,214 (-)NCBISscrofa10.2Sscrofa10.2susScr3
TIMP3
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11915,621,609 - 15,684,118 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1915,622,431 - 15,680,449 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_023666045110,320,510 - 110,382,442 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Timp3
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247501,775,744 - 1,817,385 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046247501,776,197 - 1,817,279 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Timp3
304 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:73
Count of miRNA genes:66
Interacting mature miRNAs:68
Transcripts:ENSRNOT00000005746
Prediction methods:Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
2317059Aia15Adjuvant induced arthritis QTL 152.46joint integrity trait (VT:0010548)right rear ankle joint diameter (CMO:0002150)71700459862004598Rat
61410Bw19Body weight QTL 196.20.001body mass (VT:0001259)body weight (CMO:0000012)7144782185Rat
1300176Hrtrt10Heart rate QTL 103.19heart pumping trait (VT:2000009)heart rate (CMO:0000002)766427026029351Rat
9590102Sffal5Serum free fatty acids level QTL 58.620.001blood free fatty acid amount (VT:0001553)plasma free fatty acids level (CMO:0000546)7532901950329019Rat
1578652Bmd15Bone mineral density QTL 155.2femur mineral mass (VT:0010011)trabecular volumetric bone mineral density (CMO:0001729)7986646760460686Rat
1643004Pain2Pain QTL 21mechanical nociception trait (VT:0002734)self mutilation severity score (CMO:0002145)7946224698011544Rat
631503Bp102Blood pressure QTL 1021.9arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)7144822433Rat
634336Anxrr17Anxiety related response QTL 173.66locomotor behavior trait (VT:0001392)number of entries into a discrete space in an experimental apparatus (CMO:0000960)7924703115097879Rat
10755438Coatc9Coat color QTL 90coat/hair pigmentation trait (VT:0010463)pigmented ventral coat/hair area to total ventral coat/hair area ratio (CMO:0001812)7352928048529280Rat
9590142Scort5Serum corticosterone level QTL 524.40.001blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)7131962314Rat
1582260Bw72Body weight QTL 723.20.0043body mass (VT:0001259)body weight (CMO:0000012)71579556538073970Rat
1582261Bw69Body weight QTL 693.20.0048body mass (VT:0001259)body weight (CMO:0000012)71579556538073970Rat
1582262Bw75Body weight QTL 7530.0038body mass (VT:0001259)body weight (CMO:0000012)71579556538073970Rat
2298547Neuinf5Neuroinflammation QTL 53.7nervous system integrity trait (VT:0010566)spinal cord Cd74 protein level (CMO:0002131)7946224658265113Rat
10059592Kidm45Kidney mass QTL 453.950.025kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)7757398552573985Rat
2317047Wbc4White blood cell count QTL 40.01leukocyte quantity (VT:0000217)white blood cell count (CMO:0000027)7135342956Rat
10755440Coatc10Coat color QTL 100coat/hair pigmentation trait (VT:0010463)pigmented ventral coat/hair area to total ventral coat/hair area ratio (CMO:0001812)7749649952496499Rat
2298550Neuinf6Neuroinflammation QTL 63.3nervous system integrity trait (VT:0010566)spinal cord RT1-B protein level (CMO:0002132)7127829089Rat
738033Anxrr6Anxiety related response QTL 64.1exploratory behavior trait (VT:0010471)percentage of entries into a discrete space in an experimental apparatus (CMO:0000961)71557388960573889Rat
724560Plsm3Polydactyly-luxate syndrome (PLS) morphotypes QTL 30.0003tibia length (VT:0004357)tibia length (CMO:0000450)7134000259Rat
7411566Bw136Body weight QTL 13610.40.001body mass (VT:0001259)body weight gain (CMO:0000420)7131962314Rat

Markers in Region
RH128273  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2717,523,310 - 17,523,527 (+)MAPPERmRatBN7.2
Rnor_6.0723,545,609 - 23,545,825NCBIRnor6.0
Rnor_5.0723,695,848 - 23,696,064UniSTSRnor5.0
RGSC_v3.4719,678,548 - 19,678,764UniSTSRGSC3.4
Celera714,762,644 - 14,762,860UniSTS
Cytogenetic Map7q13UniSTS
RH129267  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2717,523,345 - 17,523,536 (+)MAPPERmRatBN7.2
Rnor_6.0723,545,644 - 23,545,834NCBIRnor6.0
Rnor_5.0723,695,883 - 23,696,073UniSTSRnor5.0
RGSC_v3.4719,678,583 - 19,678,773UniSTSRGSC3.4
Celera714,762,679 - 14,762,869UniSTS
Cytogenetic Map7q13UniSTS
RH94615  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2717,524,335 - 17,524,409 (+)MAPPERmRatBN7.2
Rnor_6.0723,546,634 - 23,546,707NCBIRnor6.0
Rnor_5.0723,696,873 - 23,696,946UniSTSRnor5.0
RGSC_v3.4719,679,573 - 19,679,646UniSTSRGSC3.4
Celera714,763,669 - 14,763,742UniSTS
Cytogenetic Map7q13UniSTS
RH144261  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2717,551,976 - 17,552,083 (+)MAPPERmRatBN7.2
Rnor_6.0723,574,271 - 23,574,377NCBIRnor6.0
Rnor_5.0723,724,510 - 23,724,616UniSTSRnor5.0
RGSC_v3.4719,707,210 - 19,707,316UniSTSRGSC3.4
Celera714,791,244 - 14,791,350UniSTS
Cytogenetic Map7q13UniSTS
BI278238  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2717,523,117 - 17,523,220 (+)MAPPERmRatBN7.2
Rnor_6.0723,545,416 - 23,545,518NCBIRnor6.0
Rnor_5.0723,695,655 - 23,695,757UniSTSRnor5.0
RGSC_v3.4719,678,355 - 19,678,457UniSTSRGSC3.4
Celera714,762,451 - 14,762,553UniSTS
Cytogenetic Map7q13UniSTS
RH135110  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2717,522,418 - 17,522,611 (+)MAPPERmRatBN7.2
Rnor_6.0723,544,717 - 23,544,909NCBIRnor6.0
Rnor_5.0723,694,956 - 23,695,148UniSTSRnor5.0
RGSC_v3.4719,677,656 - 19,677,848UniSTSRGSC3.4
Celera714,761,752 - 14,761,944UniSTS
Cytogenetic Map7q13UniSTS
Timp3  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2717,523,945 - 17,524,436 (+)MAPPERmRatBN7.2
Rnor_6.0723,546,244 - 23,546,734NCBIRnor6.0
Rnor_5.0723,696,483 - 23,696,973UniSTSRnor5.0
RGSC_v3.4719,679,183 - 19,679,673UniSTSRGSC3.4
Celera714,763,279 - 14,763,769UniSTS
Cytogenetic Map7q13UniSTS
G45201  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2717,562,016 - 17,562,389 (+)MAPPERmRatBN7.2
mRatBN7.2717,562,046 - 17,562,389 (+)MAPPERmRatBN7.2
Rnor_6.0723,584,341 - 23,584,683NCBIRnor6.0
Rnor_6.0723,584,311 - 23,584,683NCBIRnor6.0
Rnor_5.0723,734,580 - 23,734,922UniSTSRnor5.0
Rnor_5.0723,734,550 - 23,734,922UniSTSRnor5.0
RGSC_v3.4719,717,250 - 19,717,622UniSTSRGSC3.4
RGSC_v3.4719,717,280 - 19,717,622UniSTSRGSC3.4
Celera714,801,206 - 14,801,548UniSTS
Celera714,801,176 - 14,801,548UniSTS
Cytogenetic Map7q13UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
nervous system
renal system
reproductive system
respiratory system
9 11 49 113 91 90 59 25 59 6 218 97 93 45 60 31

Sequence


Ensembl Acc Id: ENSRNOT00000005746   ⟹   ENSRNOP00000005746
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl717,521,919 - 17,571,839 (-)Ensembl
Rnor_6.0 Ensembl723,544,215 - 23,594,133 (-)Ensembl
RefSeq Acc Id: NM_012886   ⟹   NP_037018
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8719,408,539 - 19,459,558 (-)NCBI
mRatBN7.2717,520,827 - 17,571,850 (-)NCBI
Rnor_6.0723,544,205 - 23,594,133 (-)NCBI
Rnor_5.0723,693,364 - 23,744,404 (-)NCBI
RGSC_v3.4719,677,144 - 19,727,072 (-)RGD
Celera714,761,240 - 14,810,915 (-)RGD
Sequence:
Protein Sequences
Protein RefSeqs NP_037018 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAA75002 (Get FASTA)   NCBI Sequence Viewer  
  AAH97335 (Get FASTA)   NCBI Sequence Viewer  
  EDM17125 (Get FASTA)   NCBI Sequence Viewer  
  EDM17126 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000005746
GenBank Protein P48032 (Get FASTA)   NCBI Sequence Viewer  
RefSeq Acc Id: NP_037018   ⟸   NM_012886
- Peptide Label: precursor
- UniProtKB: P48032 (UniProtKB/Swiss-Prot),   Q4V8L0 (UniProtKB/TrEMBL),   F7FFD0 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000005746   ⟸   ENSRNOT00000005746
Protein Domains
NTR

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P48032-F1-model_v2 AlphaFold P48032 1-211 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13695091
Promoter ID:EPDNEW_R5616
Type:multiple initiation site
Name:Timp3_1
Description:TIMP metallopeptidase inhibitor 3
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0723,594,144 - 23,594,204EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:3865 AgrOrtholog
BioCyc Gene G2FUF-34643 BioCyc
Ensembl Genes ENSRNOG00000004303 Ensembl, ENTREZGENE
Ensembl Transcript ENSRNOT00000005746 ENTREZGENE
Gene3D-CATH 2.40.50.120 UniProtKB/Swiss-Prot
  3.90.370.10 UniProtKB/Swiss-Prot
IMAGE_CLONE IMAGE:7443686 IMAGE-MGC_LOAD
InterPro Netrin_domain UniProtKB/Swiss-Prot
  TIMP UniProtKB/Swiss-Prot
  TIMP-like_OB-fold UniProtKB/Swiss-Prot
  TIMP_C UniProtKB/Swiss-Prot
  TIMP_CS UniProtKB/Swiss-Prot
MGC_CLONE MGC:114345 IMAGE-MGC_LOAD
NCBI Gene 25358 ENTREZGENE
PANTHER PTHR11844 UniProtKB/Swiss-Prot
  PTHR11844:SF22 UniProtKB/Swiss-Prot
Pfam TIMP UniProtKB/Swiss-Prot
PhenoGen Timp3 PhenoGen
PROSITE NTR UniProtKB/Swiss-Prot
  TIMP UniProtKB/Swiss-Prot
RatGTEx ENSRNOG00000004303 RatGTEx
SMART NTR UniProtKB/Swiss-Prot
Superfamily-SCOP SSF50242 UniProtKB/Swiss-Prot
TIGR TC204185
UniProt F7FFD0 ENTREZGENE, UniProtKB/TrEMBL
  P48032 ENTREZGENE
  Q4V8L0 ENTREZGENE, UniProtKB/TrEMBL
  TIMP3_RAT UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2008-10-23 Timp3  TIMP metallopeptidase inhibitor 3  Timp3  tissue inhibitor of metalloproteinase 3  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-02-15 Timp3  tissue inhibitor of metalloproteinase 3  Timp3  tissue inhibitor of metalloproteinase 3 (Sorsby fundus dystrophy, pseudoinflammatory)  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2004-09-10 Timp3  tissue inhibitor of metalloproteinase 3 (Sorsby fundus dystrophy, pseudoinflammatory)    tissue inhibitor of metalloproteinase 3  Name updated 1299863 APPROVED
2002-06-10 Timp3  Tissue inhibitor of metalloproteinase 3      Symbol and Name status set to approved 70586 APPROVED