Depdc5<sup>em2Kyo</sup> (DEP domain containing 5, GATOR1 subcomplex subunit; TALEN induced mutant2, Kyo) - Rat Genome Database

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Gene: Depdc5em2Kyo (DEP domain containing 5, GATOR1 subcomplex subunit; TALEN induced mutant2, Kyo) Rattus norvegicus
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Symbol: Depdc5em2Kyo
Name: DEP domain containing 5, GATOR1 subcomplex subunit; TALEN induced mutant2, Kyo
RGD ID: 38599195
Description: TALEN mRNAs targeting exon 2 of rat Depdc5 were microinjected into fertilized eggs of Fisher 344 (F344) rats to yield two founder mutant rats named Depdc5em1kyo (c.40_44delins17/p.Gly15*) and Depdc5em2kyo (c.39_55delinsT/p.Lys13fs*8). The genome edited fragment was identified by PCR. A 267 bp band was detected for wildtype, a 279 bp band for Depdc5em1kyo mutant and a 251 bp band for Depdc5em2kyo mutant. Depdc5 mutant homozygous pups were never observed at birth. Deletion of both alleles resulted in in utero lethality started around E14.5.
ASSOCIATED WITH abnormal afterhyperpolarization; abnormal lateral ventricle morphology; abnormal neocortex morphology
Type: allele  of Depdc5  
Is Marker For: Strains:   F344-Depdc5em2Kyo+/-  
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position: No map positions available.


Phenotype Annotations     Click to see Annotation Detail View

Mammalian Phenotype
References

References - curated
# Reference Title Reference Citation
1. Depdc5 knockout rat: A novel model of mTORopathy. Marsan E, etal., Neurobiol Dis. 2016 May;89:180-9. doi: 10.1016/j.nbd.2016.02.010. Epub 2016 Feb 9.

Genomics


Related Rat Strains
The following Strains have been annotated to Depdc5em2Kyo


Expression


Sequence

Nucleotide Sequences


Additional Information