Themis<sup>m1Adej</sup> (thymocyte selection associated; mutant1, Adej) - Rat Genome Database

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Gene: Themism1Adej (thymocyte selection associated; mutant1, Adej) Rattus norvegicus
Symbol: Themism1Adej
Name: thymocyte selection associated; mutant1, Adej
RGD ID: 38599156
Description: This autosomal recessive mutation occurred spontaneously in a Brown-Norway rat colony and was identified as causing marked T cell lymphopenia. The mutation was identified as a frameshift mutation caused by a four-nucleotide insertion in the Themis gene, leading to its disruption.
ASSOCIATED WITH abnormal duodenum morphology; abnormal ileum morphology; abnormal jejunum morphology; ASSOCIATED WITH inflammatory bowel disease; T-Lymphocytopenia
Type: allele  of Themis  
Previously known as: Themis^[m1Adej]
Is Marker For: Strains:   BN-Themism1Adej  
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position: No map positions available.


References - curated
# Reference Title Reference Citation
1. A spontaneous mutation of the rat Themis gene leads to impaired function of regulatory T cells linked to inflammatory bowel disease. Chabod M, etal., PLoS Genet. 2012 Jan;8(1):e1002461. doi: 10.1371/journal.pgen.1002461. Epub 2012 Jan 19.


Related Rat Strains
The following Strains have been annotated to Themism1Adej



Nucleotide Sequences

Additional Information