Lpin1<sup>m1Hubr</sup> (lipin 1; ENU induced mutant 1, Hubr) - Rat Genome Database

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Gene: Lpin1m1Hubr (lipin 1; ENU induced mutant 1, Hubr) Rattus norvegicus
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Symbol: Lpin1m1Hubr
Name: lipin 1; ENU induced mutant 1, Hubr
RGD ID: 38599153
Description: The mutation in Crl: Wistar was created using N-ethyl-N-nitrosourea (ENU) mutagenesis. A point mutation in the 5′-end splice site of intron 18 resulting in mis-splicing, a reading frameshift, and a premature stop codon was identified. As this mutation does not induce nonsense-mediated decay, it allows the production of a truncated Lipin 1 protein lacking phosphatidate phosphatase 1 activity.
ASSOCIATED WITH abnormal sciatic nerve morphology; dysmyelination; increased cell proliferation
Type: allele  of Lpin1  
Is Marker For: Strains:   WI-Lpin1m1Hubr  
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position: No map positions available.


Phenotype Annotations     Click to see Annotation Detail View

Mammalian Phenotype
References

References - curated
# Reference Title Reference Citation
1. A hypomorphic mutation in Lpin1 induces progressively improving neuropathy and lipodystrophy in the rat. Mul JD, etal., J Biol Chem. 2011 Jul 29;286(30):26781-93. doi: 10.1074/jbc.M110.197947. Epub 2011 Jun 1.

Genomics


Related Rat Strains
The following Strains have been annotated to Lpin1m1Hubr


Expression


Sequence

Nucleotide Sequences


Additional Information