Aire<sup>em1Ang</sup> (autoimmune regulator; ZFN induced mutant1, Ang) - Rat Genome Database

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Gene: Aireem1Ang (autoimmune regulator; ZFN induced mutant1, Ang) Rattus norvegicus
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Symbol: Aireem1Ang
Name: autoimmune regulator; ZFN induced mutant1, Ang
RGD ID: 38599148
Description: The mutations created by ZFN reagents targeting to a DNA sequence 59-TGCCACCCAGACCCCCCACAAAGAGAAGAGCCCTGGAAGAG- 39 in exon 3 of the Aire gene. This mutant carries a 17-bp deletion in the nuclear localization signal sequence, causing a premature stop codon.
ASSOCIATED WITH abnormal NK cell number; abnormal thymus morphology; alopecia; ASSOCIATED WITH autoimmune polyendocrine syndrome
Type: allele  of Aire  
Is Marker For: Strains:   BN-Aireem1Ang-/-   SD.BN-Aireem1Ang-/-  
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position: No map positions available.


Disease Annotations     Click to see Annotation Detail View

Phenotype Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Breakdown of Immune Tolerance in AIRE-Deficient Rats Induces a Severe Autoimmune Polyendocrinopathy-Candidiasis-Ectodermal Dystrophy-like Autoimmune Disease. Ossart J, etal., J Immunol. 2018 Aug 1;201(3):874-887. doi: 10.4049/jimmunol.1701318. Epub 2018 Jun 29.

Genomics


Related Rat Strains
The following Strains have been annotated to Aireem1Ang


Expression


Sequence

Nucleotide Sequences


Additional Information