Th (tyrosine hydroxylase) - Rat Genome Database

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Pathways
Gene: Th (tyrosine hydroxylase) Rattus norvegicus
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Symbol: Th
Name: tyrosine hydroxylase
RGD ID: 3853
Description: Enables several functions, including cation binding activity; tetrahydrobiopterin binding activity; and tyrosine 3-monooxygenase activity. Involved in several processes, including aminergic neurotransmitter loading into synaptic vesicle; carboxylic acid metabolic process; and cellular response to nicotine. Located in several cellular components, including cytoplasmic vesicle; perikaryon; and terminal bouton. Used to study Parkinson's disease. Biomarker of several diseases, including brain disease (multiple); hyperprolactinemia; polycystic ovary syndrome; portal hypertension; and uremia. Human ortholog(s) of this gene implicated in Parkinson's disease; Parkinsonism; hypertension; and obesity. Orthologous to human TH (tyrosine hydroxylase); PARTICIPATES IN aromatic L-amino acid decarboxylase deficiency pathway; catecholamine biosynthetic pathway; dopamine biosynthetic pathway; INTERACTS WITH "2',5'-Dideoxyadenosine"; (+)-catechin; (+)-sesamin.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: The; tyrosine 3-hydroxylase; tyrosine 3-monooxygenase
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.21198,071,500 - 198,078,832 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1198,071,503 - 198,109,767 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1206,450,387 - 206,457,507 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01213,537,252 - 213,544,373 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01206,211,403 - 206,218,524 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01216,073,034 - 216,080,287 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1216,073,031 - 216,080,287 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01222,935,462 - 222,942,715 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41203,164,253 - 203,171,506 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11203,317,712 - 203,324,972 (-)NCBI
Celera1195,642,057 - 195,649,203 (-)NCBICelera
RH 2.0 Map11080.1RGD
Cytogenetic Map1q41NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View
brain disease  (ISO)
Brain Injuries  (IEP)
brain ischemia  (IEP)
Catalepsy  (ISO)
congestive heart failure  (IEP,ISO)
Contusions  (IEP)
delta beta-thalassemia  (ISO)
depressive disorder  (IEP)
developmental and epileptic encephalopathy  (ISO)
Drug-Induced Dyskinesia  (ISO)
dystonia  (ISO)
dystonia 5  (ISO)
early infantile epileptic encephalopathy  (ISO)
epilepsy  (IEP)
essential hypertension  (ISO)
Experimental Diabetes Mellitus  (IEP)
Experimental Liver Cirrhosis  (IEP)
generalized dystonia  (ISO)
genetic disease  (ISO)
heart disease  (ISO)
hepatocellular carcinoma  (ISO)
Hyperkinesis  (ISO)
Hyperproinsulinemia  (ISO)
hyperprolactinemia  (IEP)
hypertension  (IEP,ISO)
hypoglycemia  (IEP)
Hypoinsulinemia  (ISO)
immunodeficiency 39  (ISO)
intellectual disability  (ISO)
learning disability  (ISO)
Lewy body dementia  (ISO)
Machado-Joseph disease  (IEP)
maturity-onset diabetes of the young  (ISO)
maturity-onset diabetes of the young type 1  (ISO)
maturity-onset diabetes of the young type 10  (ISO)
middle cerebral artery infarction  (IEP)
myocardial infarction  (ISO)
neonatal diabetes  (ISO)
Nerve Degeneration  (ISO)
neuroblastoma  (ISO)
neuronal ceroid lipofuscinosis  (ISO)
obesity  (ISO)
Parkinson's disease  (IEP,IMP,ISO)
Parkinsonism  (IEP,ISO)
Permanent Neonatal Diabetes Mellitus 4  (ISO)
pheochromocytoma  (ISO)
polycystic ovary syndrome  (IEP)
portal hypertension  (IEP)
Reperfusion Injury  (ISO)
Segawa Syndrome, Autosomal Recessive  (ISO)
transient neonatal diabetes mellitus  (ISO)
type 1 diabetes mellitus  (ISO)
type 1 diabetes mellitus 2  (ISO)
type 2 diabetes mellitus  (ISO)
Type 2 Diabetes Mellitus 1  (ISO)
uremia  (IEP)
withdrawal disorder  (IEP)

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
"2',5'-Dideoxyadenosine"  (EXP)
(+)-catechin  (EXP)
(+)-sesamin  (EXP)
(+)-taxifolin  (EXP)
(-)-epigallocatechin 3-gallate  (EXP)
(-)-selegiline  (EXP)
(R)-adrenaline  (EXP,ISO)
(R)-noradrenaline  (EXP,ISO)
(R,R,R)-alpha-tocopherol  (EXP)
(S)-AMPA  (EXP)
(S)-amphetamine  (ISO)
(S)-naringenin  (EXP)
(S)-nicotine  (EXP,ISO)
1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine  (ISO)
1-Naphthylacetylspermine  (EXP)
15-deoxy-Delta(12,14)-prostaglandin J2  (EXP)
17beta-estradiol  (EXP,ISO)
2,2',4,4',5,5'-hexachlorobiphenyl  (EXP)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,4-D  (EXP)
2-methyl-6-(phenylethynyl)pyridine  (EXP)
3,4-dihydroxyphenylacetaldehyde  (EXP)
3,5-dichloro-N-[[(2S)-1-ethyl-2-pyrrolidinyl]methyl]-2-hydroxy-6-methoxybenzamide  (ISO)
3,7-dihydropurine-6-thione  (EXP)
3-\{1-[3-(dimethylamino)propyl]-1H-indol-3-yl\}-4-(1H-indol-3-yl)-1H-pyrrole-2,5-dione  (EXP)
3-Amino-1-methyl-5H-pyrido[4,3-b]indole  (EXP)
3-hydroxybutyric acid  (ISO)
3-methyladenine  (EXP)
3-phenylprop-2-enal  (ISO)
4,4'-sulfonyldiphenol  (EXP,ISO)
4-phenylbutyric acid  (ISO)
5-(2-chloroethyl)-4-methylthiazole  (ISO)
5-aza-2'-deoxycytidine  (ISO)
5-fluorouracil  (ISO)
6-propyl-2-thiouracil  (EXP)
7-NITROINDAZOLE  (ISO)
8-bromo-3',5'-cyclic GMP  (EXP)
9-cis-retinoic acid  (ISO)
acetic acid  (ISO)
acetylcholine  (EXP)
acrylamide  (EXP)
acrylonitrile  (EXP)
aflatoxin B1  (ISO)
Aflatoxin B2 alpha  (ISO)
agmatine  (EXP)
albiflorin  (EXP)
all-trans-retinoic acid  (ISO)
AM-251  (EXP)
amentoflavone  (ISO)
aminoguanidine  (ISO)
amitraz  (EXP)
amitrole  (EXP)
ammonium chloride  (EXP)
amphetamine  (EXP,ISO)
apigenin  (EXP)
apocynin  (EXP)
Aroclor 1254  (EXP,ISO)
arsane  (EXP,ISO)
arsenic atom  (EXP,ISO)
arsenite(3-)  (EXP,ISO)
arsenous acid  (ISO)
Asiaticoside  (EXP)
atrazine  (EXP,ISO)
baicalein  (ISO)
Bardoxolone methyl  (ISO)
benzo[a]pyrene  (EXP,ISO)
bicuculline  (EXP)
bis(2-chloroethyl) sulfide  (ISO)
bis(2-ethylhexyl) phthalate  (EXP,ISO)
bisphenol A  (EXP,ISO)
bisphenol F  (EXP,ISO)
BQ 123  (EXP)
bromochloroacetic acid  (ISO)
bucladesine  (EXP)
butanal  (ISO)
Butylparaben  (EXP)
cadmium atom  (ISO)
cadmium dichloride  (EXP)
caffeine  (ISO)
calcitriol  (EXP,ISO)
cannabidiol  (ISO)
carmustine  (EXP)
carnosic acid  (EXP)
Carnosol  (ISO)
carvedilol  (EXP)
chelerythrine  (EXP)
chitosan  (EXP)
Chloralose  (EXP)
chlorisondamine  (EXP)
chlorpyrifos  (EXP,ISO)
cisplatin  (ISO)
clonidine  (EXP)
clonidine (amino form)  (EXP)
clonidine (imino form)  (EXP)
clozapine  (EXP,ISO)
cobalt dichloride  (EXP,ISO)
cocaine  (EXP,ISO)
colforsin daropate hydrochloride  (EXP,ISO)
copper atom  (ISO)
copper(0)  (ISO)
copper(II) sulfate  (EXP,ISO)
corticosterone  (ISO)
Cuprizon  (EXP)
curcumin  (EXP,ISO)
cyanazine  (EXP)
cyclosporin A  (ISO)
cyhalothrin  (EXP)
cypermethrin  (EXP)
cytarabine  (ISO)
dabigatran  (EXP)
DDE  (EXP)
desferrioxamine B  (EXP)
desipramine  (EXP)
dexamethasone  (EXP)
diarsenic trioxide  (ISO)
diazinon  (EXP)
dichlorvos  (EXP)
dieldrin  (EXP)
diethyldithiocarbamic acid  (EXP)
dioxygen  (EXP)
dipyridamole  (EXP)
dopamine  (EXP,ISO)
dopaminechrome (enol form)  (EXP)
edaravone  (EXP)
elemental selenium  (EXP)
enzacamene  (EXP)
epibatidine  (EXP)
ethanol  (EXP,ISO)
fasudil  (EXP)
fenvalerate  (EXP)
ferrostatin-1  (ISO)
fipronil  (ISO)
flavonoids  (EXP)
fluoxetine  (EXP,ISO)
formaldehyde  (ISO)
fructose  (ISO)
ganglioside GM1  (EXP)
genistein  (EXP,ISO)
geraniol  (ISO)
ginkgetin  (ISO)
ginsenoside Re  (ISO)
glyburide  (ISO)
guanethidine  (EXP)
GW 1929  (EXP)
haloperidol  (EXP)
heptachlor  (ISO)
herbicide  (EXP)
hydrogen peroxide  (EXP,ISO)
icariin  (EXP)
idazoxan  (EXP)
imidacloprid  (EXP)
juglone  (ISO)
ketoconazole  (ISO)
KT 5720  (EXP)
L-ascorbic acid  (EXP,ISO)
lead(0)  (ISO)
linalool  (EXP)
linuron  (EXP)
lipopolysaccharide  (EXP,ISO)
lithium atom  (EXP)
lithium hydride  (EXP)
lovastatin  (ISO)
LY294002  (ISO)
maneb  (EXP,ISO)
manganese atom  (EXP,ISO)
manganese(0)  (EXP,ISO)
manganese(II) chloride  (EXP,ISO)
manganese(II) sulfate  (EXP)
melatonin  (EXP,ISO)
mephedrone  (EXP,ISO)
mercaptopurine  (EXP)
metformin  (EXP)
methamphetamine  (EXP,ISO)
methoxychlor  (EXP)
methyllycaconitine  (ISO)
methylmercury chloride  (ISO)
methylphenidate  (ISO)
mevalonic acid  (ISO)
mifepristone  (EXP,ISO)
mono(2-ethylhexyl) phthalate  (EXP,ISO)
monocrotophos  (EXP)
monosodium L-glutamate  (EXP)
montelukast  (EXP)
morphine  (EXP,ISO)
N(gamma)-nitro-L-arginine methyl ester  (ISO)
N-[2-(4-bromocinnamylamino)ethyl]isoquinoline-5-sulfonamide  (EXP)
N-acetyl-L-cysteine  (EXP)
N-ethyl-N-nitrosourea  (EXP)
N-ethylmaleimide  (EXP)
N-methyl-4-phenylpyridinium  (EXP,ISO)
N-nitrosodiethylamine  (EXP,ISO)
naloxone  (EXP,ISO)
naltrexone  (ISO)
nickel atom  (EXP)
nickel dichloride  (ISO)
nicotine  (EXP,ISO)
nimodipine  (EXP)
nitroprusside  (EXP)
Nookatone  (EXP)
Norbinaltorphimine  (ISO)
olanzapine  (EXP)
oleuropein  (ISO)
oridonin  (EXP)
oxidopamine  (EXP,ISO)
P(1),P(4)-bis(5'-adenosyl) tetraphosphate  (EXP)
paracetamol  (EXP)
paraquat  (EXP,ISO)
pentanal  (ISO)
perfluorodecanoic acid  (ISO)
perfluorododecanoic acid  (ISO)
perfluorononanoic acid  (ISO)
perfluorooctane-1-sulfonic acid  (ISO)
perfluorooctanoic acid  (ISO)
perfluoroundecanoic acid  (ISO)
permethrin  (EXP)
phencyclidine  (ISO)
Phenelzine  (EXP)
phenethyl caffeate  (EXP)
phorbol 13-acetate 12-myristate  (EXP,ISO)
piperazine  (ISO)
piperonyl butoxide  (ISO)
pirinixic acid  (ISO)
pregabalin  (ISO)
probenecid  (ISO)
progesterone  (EXP)
propanal  (ISO)
propionic acid  (EXP)
propofol  (ISO)
prothioconazole  (ISO)
purine-6-thiol  (EXP)
pyrrolidine dithiocarbamate  (ISO)
pyrroloquinoline quinone  (EXP)
quercetin  (EXP)
quercetin 3-O-beta-D-glucofuranoside  (EXP)
quercetin 3-O-beta-D-glucopyranoside  (EXP)
reserpine  (EXP,ISO)
resveratrol  (EXP,ISO)
rimonabant  (EXP)
risperidone  (EXP)
rotenone  (EXP,ISO)
rottlerin  (EXP,ISO)
rutin  (EXP)
salubrinal  (EXP)
saxagliptin  (EXP)
SB 203580  (EXP)
SCH 23390  (ISO)
selenium atom  (EXP)
simazine  (EXP,ISO)
sodium arsenite  (EXP,ISO)
sodium chloride  (EXP)
spiperone  (EXP)
streptozocin  (EXP)
sulforaphane  (ISO)
sulpiride  (EXP,ISO)
Talipexole dihydrochloride  (ISO)
tamoxifen  (EXP,ISO)
taurine  (ISO)
telmisartan  (ISO)
testosterone  (EXP)
topiramate  (ISO)
trichloroethene  (EXP)
triprolidine  (EXP)
tris(2-butoxyethyl) phosphate  (ISO)
urethane  (EXP)
valproic acid  (EXP,ISO)
vitamin D  (EXP)
vorinostat  (ISO)
WIN 55212-2  (EXP,ISO)
wortmannin  (EXP,ISO)
Y-27632  (ISO)
zearalenone  (ISO)
zinc atom  (EXP)
zinc sulfate  (EXP)
zinc(0)  (EXP)
zonisamide  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
aminergic neurotransmitter loading into synaptic vesicle  (IDA)
animal organ morphogenesis  (ISO)
aromatic amino acid metabolic process  (IEA)
catecholamine biosynthetic process  (IDA)
cellular response to alkaloid  (IEP)
cellular response to glucose stimulus  (IEP)
cellular response to growth factor stimulus  (IEP)
cellular response to manganese ion  (IEP)
cellular response to nicotine  (IEP)
cellular response to xenobiotic stimulus  (IEP)
cerebral cortex development  (IEP)
circadian sleep/wake cycle  (IEP)
cognition  (IEP)
dopamine biosynthetic process  (IEA,ISO)
dopamine biosynthetic process from tyrosine  (IBA,IDA,IMP,ISO)
eating behavior  (ISO)
embryonic camera-type eye morphogenesis  (ISO)
epinephrine biosynthetic process  (ISO)
eye photoreceptor cell development  (ISO)
fatty acid metabolic process  (IEP)
glycoside metabolic process  (IEP)
heart development  (IBA,IDA,ISO)
hyaloid vascular plexus regression  (ISO,ISS)
isoquinoline alkaloid metabolic process  (IEP)
learning  (ISO)
locomotory behavior  (ISO)
mating behavior  (ISO)
memory  (ISO)
norepinephrine biosynthetic process  (ISO)
phthalate metabolic process  (IEP)
phytoalexin metabolic process  (IEP)
regulation of heart contraction  (ISO)
response to activity  (IEP)
response to amphetamine  (IEP)
response to corticosterone  (IEP)
response to electrical stimulus  (IEP)
response to estradiol  (IEP)
response to ethanol  (IBA,IEP,ISO)
response to ether  (IEP)
response to growth factor  (IEP)
response to herbicide  (IEP)
response to hypoxia  (IBA,IDA,IEP,ISO)
response to immobilization stress  (IEP)
response to insecticide  (IEP)
response to isolation stress  (IEP)
response to light stimulus  (IEP)
response to lipopolysaccharide  (IEP)
response to metal ion  (IEP)
response to nicotine  (IEP)
response to nutrient levels  (IEP)
response to organic cyclic compound  (IEP)
response to peptide hormone  (IEP)
response to pyrethroid  (IEP)
response to salt stress  (IEP)
response to steroid hormone  (IEP)
response to xenobiotic stimulus  (IEP)
response to zinc ion  (IEP)
social behavior  (IEP)
sphingolipid metabolic process  (IEP)
synaptic transmission, dopaminergic  (ISO)
terpene metabolic process  (IEP)
visual perception  (ISO)

Cellular Component

References

References - curated
# Reference Title Reference Citation
1. Vasopressinergic neurons of the supraoptic nucleus in perinatal rats: reaction to osmotic stimulation and its regulation. Abramova MA, etal., Brain Struct Funct. 2011 Jan;215(3-4):195-207. Epub 2010 Nov 27.
2. Alterations in cognitive function and behavioral response to amphetamine induced by prenatal inflammation are dependent on the stage of pregnancy. Aguilar-Valles A and Luheshi GN, Psychoneuroendocrinology. 2010 Oct 7.
3. Changes with aging in the dopaminergic and noradrenergic innervation of rat neocortex. Allard S, etal., Neurobiol Aging. 2010 Jan 21.
4. The activity of some neurotransmitter-synthetizing enzymes in experimental cobalt epilepsy. Altamura AC, etal., Neurosci Lett. 1978 Jan;7(1):83-7.
5. Striatal and nigral pathology in a lentiviral rat model of Machado-Joseph disease. Alves S, etal., Hum Mol Genet. 2008 Jul 15;17(14):2071-83. Epub 2008 Apr 1.
6. Nicotine dependence in a prospective population-based study of adolescents: the protective role of a functional tyrosine hydroxylase polymorphism. Anney RJ, etal., Pharmacogenetics. 2004 Feb;14(2):73-81.
7. Increasing proportions of tyrosine hydroxylase-immunoreactive interneurons colocalize with choline acetyltransferase or vasoactive intestinal peptide in the developing rat cerebral cortex. Asmus SE, etal., Brain Res. 2011 Feb 3.
8. Sexual dimorphism in locus coeruleus dendritic morphology: A structural basis for sex differences in emotional arousal. Bangasser D, etal., Physiol Behav. 2011 Mar 5.
9. A human tyrosine hydroxylase isoform associated with progressive supranuclear palsy shows altered enzymatic activity. Bodeau-Pean S, etal., J Biol Chem. 1999 Feb 5;274(6):3469-75.
10. Selective losses of brainstem catecholamine neurons after hypoxia-ischemia in the immature rat pup. Buller KM, etal., Pediatr Res. 2008 Apr;63(4):364-9.
11. Activation of Different Neuronal Phenotypes in the Rat Brain Induced by Liver Ischemia-Reperfusion Injury: Dual Fos/Neuropeptide Immunohistochemistry. Bundzikova J, etal., Cell Mol Neurobiol. 2010 Nov 9.
12. A biochemical and functional protein complex involving dopamine synthesis and transport into synaptic vesicles. Cartier EA, etal., J Biol Chem. 2010 Jan 15;285(3):1957-66. Epub 2009 Nov 10.
13. Continuous DOPA synthesis from a single AAV: dosing and efficacy in models of Parkinson's disease. CederfjÀll E, etal., Sci Rep. 2013;3:2157. doi: 10.1038/srep02157.
14. Mono-(2-ethylhexyl) phthalate impairs neurodevelopment: Inhibition of proliferation and promotion of differentiation in PC12 cells. Chen T, etal., Toxicol Lett. 2011 Feb 25;201(1):34-41. Epub 2010 Dec 9.
15. Evaluation of anti-Fas ligand-induced apoptosis and neural differentiation of PC12 cells treated with nerve growth factor using small interfering RNA method and sampling by microdialysis. Chiou SH, etal., Anal Biochem. 2007 Apr 1;363(1):46-57. Epub 2007 Jan 17.
16. Spectroscopy and kinetics of wild-type and mutant tyrosine hydroxylase: mechanistic insight into O2 activation. Chow MS, etal., J Am Chem Soc. 2009 Jun 10;131(22):7685-98.
17. Down-regulation of genes related to the adrenergic system may contribute to splanchnic vasodilation in rat portal hypertension. Coll M, etal., J Hepatol. 2008 Jul;49(1):43-51. Epub 2008 Apr 18.
18. Atrophy of mesenteric sympathetic innervation may contribute to splanchnic vasodilation in rat portal hypertension. Coll M, etal., Liver Int. 2010 Apr;30(4):593-602. Epub 2009 Nov 30.
19. Aging of the rat mesostriatal system: differences between the nigrostriatal and the mesolimbic compartments. Cruz-Muros I, etal., Exp Neurol. 2007 Mar;204(1):147-61. Epub 2006 Nov 16.
20. Tyrosine hydroxylase Val-81-Met polymorphism associated with early-onset alcoholism. Dahmen N, etal., Psychiatr Genet. 2005 Mar;15(1):13-6.
21. Vascular-dependent effects of elevated glucose on postganglionic sympathetic neurons. Damon DH Am J Physiol Heart Circ Physiol. 2011 Jan 7.
22. Measurement of intrinsic rate constants in the tyrosine hydroxylase reaction. Eser BE and Fitzpatrick PF, Biochemistry. 2010 Jan 26;49(3):645-52.
23. Behavioral recovery in 6-hydroxydopamine-lesioned rats by cotransduction of striatum with tyrosine hydroxylase and aromatic L-amino acid decarboxylase genes using two separate adeno-associated virus vectors. Fan DS, etal., Hum Gene Ther. 1998 Nov 20;9(17):2527-35.
24. Reduction and oxidation of the active site iron in tyrosine hydroxylase: kinetics and specificity. Frantom PA, etal., Biochemistry. 2006 Feb 21;45(7):2372-9.
25. Moderate Caloric Restriction during Gestation in Rats Alters Adipose Tissue Sympathetic Innervation and Later Adiposity in Offspring. Garcia AP, etal., PLoS One. 2011 Feb 18;6(2):e17313.
26. Symptom-relieving and neuroprotective effects of the phytocannabinoid D(9) -THCV in animal models of Parkinson's disease. Garcia C, etal., Br J Pharmacol. 2011 Feb 16. doi: 10.1111/j.1476-5381.2011.01278.x.
27. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
28. Effect of immobilization stress on gene expression of catecholamine biosynthetic enzymes in heart auricles of socially isolated rats. Gavrilovic L, etal., Braz J Med Biol Res. 2009 Dec;42(12):1185-90. Epub 2009 Nov 6.
29. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
30. Locus ceruleus and anterior cingulate cortex sustain wakefulness in a novel environment. Gompf HS, etal., J Neurosci. 2010 Oct 27;30(43):14543-51.
31. Association study with 33 single-nucleotide polymorphisms in 11 candidate genes for hypertension in Chinese. Gu D, etal., Hypertension. 2006 Jun;47(6):1147-54. Epub 2006 Apr 24.
32. Tyrosine hydroxylase deficiency causes progressive encephalopathy and dopa-nonresponsive dystonia. Hoffmann GF, etal., Ann Neurol. 2003;54 Suppl 6:S56-65.
33. A single RNA species injected in Xenopus oocyte directs the synthesis of active tyrosine hydroxylase. Horellou P, etal., FEBS Lett. 1986 Sep 1;205(1):6-10.
34. Dopaminergic projections from midbrain to primary motor cortex mediate motor skill learning. Hosp JA, etal., J Neurosci. 2011 Feb 16;31(7):2481-7.
35. Catalponol enhances dopamine biosynthesis and protects against L-DOPA-induced cytotoxicity in PC12 cells. Huang HS, etal., J Asian Nat Prod Res. 2009 Oct;11(10):867-75.
36. Effects of insulin treatment without and with recurrent hypoglycemia on hypoglycemic counterregulation and adrenal catecholamine-synthesizing enzymes in diabetic rats. Inouye KE, etal., Endocrinology. 2006 Apr;147(4):1860-70. Epub 2006 Jan 5.
37. Influences of dopaminergic lesion on epidermal growth factor-ErbB signals in Parkinson's disease and its model: neurotrophic implication in nigrostriatal neurons. Iwakura Y, etal., J Neurochem. 2005 May;93(4):974-83.
38. Modulation of sphingosine 1-phosphate and tyrosine hydroxylase in the stress-induced anxiety. Jang S, etal., Neurochem Res. 2011 Feb;36(2):258-67. Epub 2010 Nov 13.
39. Angiotensin II AT(1) and AT(2) receptors contribute to maintain basal adrenomedullary norepinephrine synthesis and tyrosine hydroxylase transcription. Jezova M, etal., Endocrinology 2003 May;144(5):2092-101.
40. Induction of dopamine biosynthesis by l-DOPA in PC12 cells: implications of L-DOPA influx and cyclic AMP. Jin CM, etal., Eur J Pharmacol. 2008 Sep 4;591(1-3):88-95. Epub 2008 Jun 19.
41. Effects of asimilobine on dopamine biosynthesis and l-DOPA-induced cytotoxicity in PC12 cells. Jin CM, etal., J Asian Nat Prod Res. 2008 Jul-Aug;10(7-8):747-55.
42. Direct phosphorylation of brain tyrosine hydroxylase by cyclic AMP-dependent protein kinase: mechanism of enzyme activation. Joh TH, etal., Proc Natl Acad Sci U S A. 1978 Oct;75(10):4744-8.
43. Paraventricular nucleus corticotrophin releasing hormone contributes to sympathoexcitation via interaction with neurotransmitters in heart failure. Kang YM, etal., Basic Res Cardiol. 2011 Feb 2.
44. KEGG: Kyoto Encyclopedia of Genes and Genomes KEGG
45. High frequency stimulation of the subthalamic nucleus impacts adult neurogenesis in a rat model of Parkinson's disease. Khaindrava V, etal., Neurobiol Dis. 2011 Feb 3.
46. Neuroprotective effects of curcumin on 6-hydroxydopamine-induced Parkinsonism in rats: behavioral, neurochemical and immunohistochemical studies. Khuwaja G, etal., Brain Res. 2011 Jan 12;1368:254-63. Epub 2010 Oct 15.
47. Anti-stress effects of ginseng via down-regulation of tyrosine hydroxylase (TH) and dopamine beta-hydroxylase (DBH) gene expression in immobilization-stressed rats and PC12 cells. Kim Y, etal., Nutr Res Pract. 2010 Aug;4(4):270-5. Epub 2010 Aug 31.
48. DNA polymorphisms in the tyrosine hydroxylase and GNB3 genes: association with unexpected death from acute myocardial infarction and increased heart weight. Klintschar M, etal., Forensic Sci Int. 2005 Oct 29;153(2-3):142-6. Epub 2004 Nov 6.
49. Long-term gonadectomy affects the density of tyrosine hydroxylase- but not dopamine-beta-hydroxylase-, choline acetyltransferase- or serotonin-immunoreactive axons in the medial prefrontal cortices of adult male rats. Kritzer MF Cereb Cortex 2003 Mar;13(3):282-96.
50. Effect of zinc and paraquat co-exposure on neurodegeneration: Modulation of oxidative stress and expression of metallothioneins, toxicant responsive and transporter genes in rats. Kumar A, etal., Free Radic Res. 2010 Aug;44(8):950-65.
51. Activation of tyrosine hydroxylase by intermittent hypoxia: involvement of serine phosphorylation. Kumar GK, etal., J Appl Physiol. 2003 Aug;95(2):536-44. Epub 2003 Apr 11.
52. Catecholaminergic systems in stress: structural and molecular genetic approaches. Kvetnansky R, etal., Physiol Rev. 2009 Apr;89(2):535-606.
53. Prenatal morphine exposure affects sympathoadrenal axis activity and serotonin metabolism in adult male rats both under basal conditions and after an ether inhalation stress. Laborie C, etal., Neurosci Lett. 2005 Jun 24;381(3):211-6.
54. Upregulation of neuronal nitric oxide synthase mRNA and protein in adrenal medulla of water-deprived rats. Lai FJ, etal., J Histochem Cytochem. 2005 Jan;53(1):45-53.
55. Effects of anonaine on dopamine biosynthesis and L-DOPA-induced cytotoxicity in PC12 cells. Lee JJ, etal., Molecules. 2008 Feb 27;13(2):475-87.
56. Histone acetylation and expression of mono-aminergic transmitters synthetases involved in CUS-induced depressive rats. Liu D, etal., Exp Biol Med (Maywood). 2014 Mar;239(3):330-6. doi: 10.1177/1535370213513987. Epub 2014 Feb 4.
57. The inhibitory effects of deltamethrin on dopamine biosynthesis in rat PC12 cells. Liu GP and Shi N, Toxicol Lett. 2006 Mar 1;161(3):195-9. Epub 2005 Oct 17.
58. A point mutation in the tyrosine hydroxylase gene associated with Segawa's syndrome. Ludecke B, etal., Hum Genet. 1995 Jan;95(1):123-5.
59. Ovarian expression of alpha (1)- and beta (2)-adrenoceptors and p75 neurotrophin receptors in rats with steroid-induced polycystic ovaries. Manni L, etal., Auton Neurosci. 2005 Mar 31;118(1-2):79-87.
60. Dopaminergic system dysregulation in the mrsk2_KO mouse, an animal model of the Coffin-Lowry syndrome. Marques Pereira P, etal., J Neurochem. 2008 Dec;107(5):1325-34. Epub 2008 Sep 24.
61. Time course analysis of tyrosine hydroxylase and angiotensinogen mRNA expression in central nervous system of rats submitted to experimental hypertension. Maximino JR, etal., Neurosci Res. 2006 Jul;55(3):292-9. Epub 2006 May 2.
62. Limited proteolysis of tyrosine hydroxylase identifies residues 33-50 as conformationally sensitive to phosphorylation state and dopamine binding. McCulloch RI and Fitzpatrick PF, Arch Biochem Biophys. 1999 Jul 1;367(1):143-5. doi: 10.1006/abbi.1999.1259.
63. Regional and subcellular compartmentation of the dopamine transporter and tyrosine hydroxylase in the rat ventral pallidum. Mengual E and Pickel VM, J Comp Neurol. 2004 Jan 12;468(3):395-409.
64. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
65. Gene expression of catecholamine synthesizing enzymes in A5 cell group and modulation of tyrosine hydroxylase mRNA by immobilization stress. Micutkova L, etal., Endocr Regul 2001 Dec;35(4):195-200.
66. Profound changes in dopaminergic neurotransmission in the prefrontal cortex in response to flattening of the diurnal glucocorticoid rhythm: implications for bipolar disorder. Minton GO, etal., Neuropsychopharmacology. 2009 Sep;34(10):2265-74. Epub 2009 Jun 3.
67. Chronic estradiol exposure induces oxidative stress in the hypothalamus to decrease hypothalamic dopamine and cause hyperprolactinemia. Mohankumar SM, etal., Am J Physiol Regul Integr Comp Physiol. 2011 Mar;300(3):R693-9. Epub 2010 Dec 22.
68. The effect of streptozotocin-induced diabetes on the rat seminal vesicle: A possible pathophysiological basis for disorders of ejaculation. Morrison JF, etal., Ann N Y Acad Sci. 2006 Nov;1084:267-79.
69. Decreased tyrosine hydroxylase activity in the adrenals of spontaneously hypertensive rats. Moura E, etal., Life Sci. 2005 May 6;76(25):2953-64. Epub 2005 Jan 27.
70. Developmental expression of delta-opioid receptors during maturation of the parasympathetic, sympathetic, and sensory innervations of the neonatal heart: early targets for opioid regulation of autonomic control. Mousa SA, etal., J Comp Neurol. 2011 Apr 1;519(5):957-71. doi: 10.1002/cne.22560.
71. Melatonin attenuates the amphetamine-induced decrease in vesicular monoamine transporter-2 expression in postnatal rat striatum. Mukda S, etal., Neurosci Lett. 2011 Jan 20;488(2):154-7. Epub 2010 Nov 13.
72. Characterisation of a novel model of Parkinson's disease by intra-striatal infusion of the pesticide rotenone. Mulcahy P, etal., Neuroscience. 2011 Jan 26.
73. Activities of cerebral dihydropteridine reductase and tyrosine hydroxylase in chronic uremia in rats. Mullen BJ and Wang M, J Nutr. 1986 Jul;116(7):1298-305.
74. Mechanisms involved in the long-term modulation of tyrosine hydroxylase by endothelins in the olfactory bulb of normotensive rats. Nabhen SL, etal., Neurochem Int. 2011 Feb;58(2):196-205. Epub 2010 Dec 1.
75. Treadmill training improves motor skills and increases tyrosine hydroxylase immunoreactivity in the substantia nigra pars compacta in diabetic rats. Nascimento PS, etal., Brain Res. 2011 Mar 25;1382:173-80. Epub 2011 Jan 26.
76. CRF2 mediates the increased noradrenergic activity in the hypothalamic paraventricular nucleus and the negative state of morphine withdrawal in rats. Navarro-Zaragoza J, etal., Br J Pharmacol. 2011 Feb;162(4):851-62. doi: 10.1111/j.1476-5381.2010.01090.x.
77. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
78. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
79. Effects of Glycyrrhizae Radix on Repeated Restraint Stress-induced Neurochemical and Behavioral Responses. Park HJ, etal., Korean J Physiol Pharmacol. 2010 Dec;14(6):371-6. Epub 2010 Dec 31.
80. Ethanol consumption increases rat stress hormones and adrenomedullary gene expression. Patterson-Buckendahl P, etal., Alcohol. 2005 Nov;37(3):157-66.
81. A role for alpha-synuclein in the regulation of dopamine biosynthesis. Perez RG, etal., J Neurosci. 2002 Apr 15;22(8):3090-9.
82. Leptin promotes dopamine transporter and tyrosine hydroxylase activity in the nucleus accumbens of Sprague-Dawley rats. Perry ML, etal., J Neurochem. 2010 Aug;114(3):666-74. Epub 2010 Apr 20.
83. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
84. SMPDB Annotation Import Pipeline Pipeline to import SMPDB annotations from SMPDB into RGD
85. Social hierarchy affects gene expression for catecholamine biosynthetic enzymes in rat adrenal glands. Pohorecky LA, etal., Neuroendocrinology. 2004;80(1):42-51. Epub 2004 Sep 2.
86. Interactions between orexin-immunoreactive fibers and adrenaline or noradrenaline-expressing neurons of the lower brainstem in rats and mice. Puskas N, etal., Peptides. 2010 Aug;31(8):1589-97. Epub 2010 Apr 29.
87. Hypobaric hypoxia modulates brain biogenic amines and disturbs sleep architecture. Ray K, etal., Neurochem Int. 2011 Jan;58(1):112-8. Epub 2010 Nov 12.
88. Role of the dopamine transporter in mediating the neuroleptic-induced reduction of tyrosine hydroxylase-immunoreactive midbrain neurons. Reynolds KB, etal., Brain Res. 2011 Mar 8.
89. GOA pipeline RGD automated data pipeline
90. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
91. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
92. Replication of IGF2-INS-TH*5 haplotype effect on obesity in older men and study of related phenotypes. Rodriguez S, etal., Eur J Hum Genet. 2006 Jan;14(1):109-16.
93. CHOLECYSTOKININ AND HYPOTHALAMIC CORTICOTROPIN-RELEASING FACTOR PARTICIPATE IN THE ENDOTOXIN-INDUCED HYPOPHAGIA. Rorato RC, etal., Exp Physiol. 2011 Jan 14.
94. Mutation of regulatory serines of rat tyrosine hydroxylase to glutamate: effects on enzyme stability and activity. Royo M, etal., Arch Biochem Biophys. 2005 Feb 15;434(2):266-74.
95. Regulation of tyrosine hydroxylase promoter activity by the von Hippel-Lindau tumor suppressor protein and hypoxia-inducible transcription factors. Schnell PO, etal., J Neurochem 2003 Apr;85(2):483-91.
96. Estradiol stimulates gene expression of norepinephrine biosynthetic enzymes in rat locus coeruleus. Serova L, etal., Neuroendocrinology 2002 Mar;75(3):193-200.
97. Testosterone increased blood pressure and decreased renal tyrosine hydroxylase activity in SHR/y and Wistar-Kyoto rats. Sharma U, etal., Clin Exp Hypertens. 2002 Apr;24(3):141-53.
98. Traumatic brain injury reduces striatal tyrosine hydroxylase activity and potassium-evoked dopamine release in rats. Shin SS, etal., Brain Res. 2011 Jan 19;1369:208-15. Epub 2010 Nov 1.
99. Photoperiodic suppression of drug reinstatement. Sorg BA, etal., Neuroscience. 2011 Mar 10;176:284-95. Epub 2010 Dec 24.
100. Dopaminergic neurotoxicity following pulmonary exposure to manganese-containing welding fumes. Sriram K, etal., Arch Toxicol. 2010 Jul;84(7):521-40. Epub 2010 Mar 12.
101. Cytoprotective effects of growth factors: BDNF more potent than GDNF in an organotypic culture model of Parkinson's disease. Stahl K, etal., Brain Res. 2011 Mar 10;1378:105-18. Epub 2011 Jan 12.
102. Coexpression of tyrosine hydroxylase, GTP cyclohydrolase I, aromatic amino acid decarboxylase, and vesicular monoamine transporter 2 from a helper virus-free herpes simplex virus type 1 vector supports high-level, long-term biochemical and behavioral correction of a rat model of Parkinson's disease. Sun M, etal., Hum Gene Ther. 2004 Dec;15(12):1177-96.
103. Identification of ATF-2 as a transcriptional regulator for the tyrosine hydroxylase gene. Suzuki T, etal., J Biol Chem 2002 Oct 25;277(43):40768-74.
104. Four novel mutations in the tyrosine hydroxylase gene in patients with infantile parkinsonism. Swaans RJ, etal., Ann Hum Genet. 2000 Jan;64(Pt 1):25-31.
105. Expression levels of mRNAs for catecholamine biosynthetic enzymes as markers of acute response to contusion stress during the early postmortem period. Takahashi S Tohoku J Exp Med. 2008 Nov;216(3):239-48.
106. The effects of docosahexaenoic acid on glial derived neurotrophic factor and neurturin in bilateral rat model of Parkinson's disease. Tanriover G, etal., Folia Histochem Cytobiol. 2010 Sep 30;48(3):434-41.
107. Expression of estrogen receptor-alpha and cFos in norepinephrine and epinephrine neurons of young and middle-aged rats during the steroid-induced luteinizing hormone surge. Temel S, etal., Endocrinology 2002 Oct;143(10):3974-83.
108. Tentative Sequence Identification Numbers Tentative Sequence Data IDs. TIGR Gene Index, Rat Data
109. Tyrosine hydroxylase in rat auditory midbrain: distribution and changes following deafness. Tong L, etal., Hear Res. 2005 Aug;206(1-2):28-41.
110. Isoosmotic isolation of rat brain synaptic vesicles, some of which contain tyrosine hydroxylase. Tsudzuki T and Tsujita M, J Biochem (Tokyo). 2004 Aug;136(2):239-43.
111. Dose optimization for long-term rAAV-mediated RNA interference in the nigrostriatal projection neurons. Ulusoy A, etal., Mol Ther. 2009 Sep;17(9):1574-84. Epub 2009 Jul 7.
112. Nicotine induces tyrosine hydroxylase plasticity in the neurodegenerating striatum. Urbanavicius J, etal., J Neurochem. 2007 Aug;102(3):723-30. Epub 2007 Apr 16.
113. Studies on the regulatory effect of Peony-Glycyrrhiza Decoction on prolactin hyperactivity and underlying mechanism in hyperprolactinemia rat model. Wang D, etal., Neurosci Lett. 2015 Oct 8;606:60-5. doi: 10.1016/j.neulet.2015.08.024. Epub 2015 Aug 18.
114. Expression changes of dopaminergic system-related genes in PC12 cells induced by manganese, silver, or copper nanoparticles. Wang J, etal., Neurotoxicology. 2009 Nov;30(6):926-33. Epub 2009 Sep 23.
115. Identification by hydrogen/deuterium exchange of structural changes in tyrosine hydroxylase associated with regulation. Wang S, etal., Biochemistry. 2009 Jun 9;48(22):4972-9. doi: 10.1021/bi9004254.
116. Protective effect of resveratrol derived from Polygonum cuspidatum and its liposomal form on nigral cells in Parkinsonian rats. Wang Y, etal., J Neurol Sci. 2011 Mar 2.
117. Grafting fibroblasts genetically modified to produce L-dopa in a rat model of Parkinson disease. Wolff JA, etal., Proc Natl Acad Sci U S A. 1989 Nov;86(22):9011-4.
118. Effects of scoparone on dopamine biosynthesis and L-DOPA-induced cytotoxicity in PC12 cells. Yang YJ, etal., J Neurosci Res. 2009 Jun;87(8):1929-37.
119. Decreased RGS9 protein level in the striatum of rodents undergoing MPTP or 6-OHDA neurotoxicity. Yin LL, etal., Neurosci Lett. 2010 Aug 2;479(3):231-5. doi: 10.1016/j.neulet.2010.05.068. Epub 2010 Jun 1.
120. Protein kinase C delta negatively regulates tyrosine hydroxylase activity and dopamine synthesis by enhancing protein phosphatase-2A activity in dopaminergic neurons. Zhang D, etal., J Neurosci. 2007 May 16;27(20):5349-62.
121. Targeted disruption of the tyrosine hydroxylase gene reveals that catecholamines are required for mouse fetal development. Zhou QY, etal., Nature 1995 Apr 13;374(6523):640-3.
122. alpha-Synuclein overexpression impairs mitochondrial function by associating with adenylate translocator. Zhu Y, etal., Int J Biochem Cell Biol. 2011 Feb 15.
123. Activation of cerebral peroxisome proliferator - activated receptors gamma (PPARgamma) reduces neuronal damage in the substantia nigra after transient focal cerebral ischaemia in the rat. Zuhayra M, etal., Neuropathol Appl Neurobiol. 2011 Mar 2. doi: 10.1111/j.1365-2990.2011.01169.x.
Additional References at PubMed
PMID:1672315   PMID:2857492   PMID:2882469   PMID:2884660   PMID:2889468   PMID:2896667   PMID:2905129   PMID:7518394   PMID:7592982   PMID:9228951   PMID:9520487   PMID:9753429  
PMID:9829800   PMID:10212311   PMID:10350535   PMID:10707987   PMID:10802666   PMID:10907721   PMID:11430814   PMID:11502746   PMID:11841594   PMID:11902120   PMID:11922614   PMID:12074840  
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PMID:36794530  


Genomics

Comparative Map Data
Th
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.21198,071,500 - 198,078,832 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1198,071,503 - 198,109,767 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1206,450,387 - 206,457,507 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01213,537,252 - 213,544,373 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01206,211,403 - 206,218,524 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01216,073,034 - 216,080,287 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1216,073,031 - 216,080,287 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01222,935,462 - 222,942,715 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41203,164,253 - 203,171,506 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11203,317,712 - 203,324,972 (-)NCBI
Celera1195,642,057 - 195,649,203 (-)NCBICelera
RH 2.0 Map11080.1RGD
Cytogenetic Map1q41NCBI
TH
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38112,163,929 - 2,171,815 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl112,163,929 - 2,171,815 (-)EnsemblGRCh38hg38GRCh38
GRCh37112,185,159 - 2,193,045 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36112,141,735 - 2,149,611 (-)NCBINCBI36Build 36hg18NCBI36
Build 34112,141,735 - 2,149,605NCBI
Celera112,221,752 - 2,229,624 (-)NCBICelera
Cytogenetic Map11p15.5NCBI
HuRef111,975,424 - 1,983,299 (-)NCBIHuRef
CHM1_1112,183,941 - 2,191,817 (-)NCBICHM1_1
T2T-CHM13v2.0112,253,295 - 2,261,192 (-)NCBIT2T-CHM13v2.0
Th
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm397142,446,516 - 142,453,732 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl7142,446,489 - 142,484,865 (-)EnsemblGRCm39 Ensembl
GRCm387142,892,779 - 142,899,995 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl7142,892,752 - 142,931,128 (-)EnsemblGRCm38mm10GRCm38
MGSCv377150,078,681 - 150,085,871 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv367142,702,166 - 142,709,356 (-)NCBIMGSCv36mm8
Celera7142,648,392 - 142,655,582 (-)NCBICelera
Cytogenetic Map7F5NCBI
cM Map788.06NCBI
Th
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495542213,943,552 - 13,951,137 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495542213,943,590 - 13,951,102 (-)NCBIChiLan1.0ChiLan1.0
TH
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1113,801,867 - 3,809,764 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0112,204,820 - 2,212,750 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1112,234,095 - 2,242,030 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl112,231,248 - 2,242,433 (-)Ensemblpanpan1.1panPan2
TH
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11846,327,136 - 46,334,973 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1846,327,137 - 46,335,602 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1844,936,923 - 44,944,750 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01847,006,609 - 47,014,412 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1847,006,611 - 47,014,441 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11846,455,359 - 46,462,897 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01846,035,687 - 46,043,215 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01846,782,129 - 46,789,967 (-)NCBIUU_Cfam_GSD_1.0
Th
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_0244049472,535,447 - 2,543,939 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_004936794478,614 - 487,061 (-)EnsemblSpeTri2.0
SpeTri2.0NW_004936794478,651 - 486,887 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
TH
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl21,499,620 - 1,506,170 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.121,499,628 - 1,506,180 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
TH
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.111,969,194 - 1,977,263 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl11,966,460 - 1,977,218 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366603899,163,059 - 99,174,711 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Th
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462476715,003,092 - 15,010,154 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462476715,003,073 - 15,010,207 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Th
21 total Variants
miRNA Target Status

Confirmed Target Of
miRNA GeneMature miRNAMethod NameResult TypeData TypeSupport TypePMID
Mirlet7drno-let-7d-5pMirtarbaseexternal_infoReporter assay;qRT-PCRFunctional MTI20557304

Predicted Target Of
Summary Value
Count of predictions:61
Count of miRNA genes:51
Interacting mature miRNAs:58
Transcripts:ENSRNOT00000027682
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
10059597Bp377Blood pressure QTL 3773.420.025arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)132737458199368955Rat
634314Niddm44Non-insulin dependent diabetes mellitus QTL 44blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)149393289199050459Rat
1578780Cm52Cardiac mass QTL 523.30.0001heart mass (VT:0007028)heart wet weight (CMO:0000069)181591954219808434Rat
1331749Hrtrt11Heart rate QTL 112.973heart pumping trait (VT:2000009)heart rate (CMO:0000002)194494440198211706Rat
70209Niddm23Non-insulin dependent diabetes mellitus QTL 232.82blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)194494440198324465Rat
731168Bp154Blood pressure QTL 1543.4arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)194642644214537671Rat
1354591Cm36Cardiac mass QTL 364.1heart left ventricle mass (VT:0007031)calculated heart weight (CMO:0000073)1102813953201278233Rat
1354615Cm32Cardiac mass QTL 325.2heart left ventricle mass (VT:0007031)heart left ventricle wet weight (CMO:0000071)1102813953201278233Rat
1354606Bp246Blood pressure QTL 2463.6arterial blood pressure trait (VT:2000000)pulse pressure (CMO:0000292)1102813953218753816Rat
7794788Mcs32Mammary carcinoma susceptibility QTL 322.61mammary gland integrity trait (VT:0010552)mammary tumor incidence/prevalence measurement (CMO:0000946)1115540693238914717Rat
7421630Bp362Blood pressure QTL 3620.001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)1118608292241799120Rat
631205Bp196Blood pressure QTL 19640.0001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)1118944897199050459Rat
631549Bp89Blood pressure QTL 895.7arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1123350581201284552Rat
1598853Memor3Memory QTL 34.5exploratory behavior trait (VT:0010471)total horizontal distance resulting from voluntary locomotion in an experimental apparatus (CMO:0001443)1143506580212458660Rat
737828Hcas3Hepatocarcinoma susceptibility QTL 34.9liver integrity trait (VT:0010547)liver tumorous lesion volume to total liver volume ratio (CMO:0001082)1144267353222987745Rat
2302378Insul11Insulin level QTL 113.25blood insulin amount (VT:0001560)serum insulin level (CMO:0000358)1144267353251128347Rat
7771612Cm80Cardiac mass QTL 808.4heart left ventricle mass (VT:0007031)heart left ventricle weight (CMO:0000776)1149448574221264292Rat
724531Uae5Urinary albumin excretion QTL 54urine albumin amount (VT:0002871)urine albumin level (CMO:0000130)1150700142252085212Rat
1578759Uae30Urinary albumin excretion QTL 303.30.003urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)1150700247252085048Rat
1578778Pur4Proteinuria QTL 43.30.003urine total protein amount (VT:0000032)urine total protein excretion rate (CMO:0000756)1150700247252085048Rat
1354602Bw35Body weight QTL 3512.2body mass (VT:0001259)body weight (CMO:0000012)1151162512201278233Rat
1354620Kidm19Kidney mass QTL 194kidney mass (VT:0002707)calculated kidney weight (CMO:0000160)1151162512201278233Rat
1354634Kidm12Kidney mass QTL 123.9kidney mass (VT:0002707)right kidney wet weight (CMO:0000082)1151162512201278233Rat
1354636Lmblg1Limb length QTL 16.4tibia length (VT:0004357)tibia length (CMO:0000450)1151162512201278233Rat
1354610Bw34Body weight QTL 344.1body mass (VT:0001259)body weight (CMO:0000012)1151162512256448636Rat
1354646Kidm18Kidney mass QTL 185.7kidney mass (VT:0002707)calculated kidney weight (CMO:0000160)1151162512256448636Rat
1354661Bw33Body weight QTL 335.2body mass (VT:0001259)body weight (CMO:0000012)1151162512256448636Rat
1358886Bp260Blood pressure QTL 2603.67arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)1151162766225824951Rat
1549837Hcar15Hepatocarcinoma resistance QTL 150.05liver integrity trait (VT:0010547)liver tumorous lesion number (CMO:0001068)1153136852260522016Rat
2303622Vencon6Ventilatory control QTL 60.001respiration trait (VT:0001943)respiration rate (CMO:0000289)1154561505199561505Rat
4889428Stresp24Stress response QTL 240.05heart pumping trait (VT:2000009)absolute change in electrocardiographic low frequency R-R spectral component to high frequency R-R spectral component ratio (CMO:0002162)1155866514200866514Rat
1354618Kidm15Kidney mass QTL 155kidney mass (VT:0002707)left kidney wet weight (CMO:0000083)1156677124201278233Rat
2312420Pur17Proteinuria QTL 177.10.0001urine protein amount (VT:0005160)urine total protein excretion rate (CMO:0000756)1156677124218753816Rat
1354580Scort1Serum corticosterone level QTL 13.4blood corticosterone amount (VT:0005345)blood corticosterone level (CMO:0001172)1156677124256448636Rat
61347Bp197Blood pressure QTL 1974.2arterial blood pressure trait (VT:2000000)blood pressure measurement (CMO:0000003)1158633083203633083Rat
2292222Bp307Blood pressure QTL 3073.060.0014arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1164310393213533942Rat
2292220Bp306Blood pressure QTL 3063.470.00087arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1164310393243914901Rat
619613Bp77Blood pressure QTL 770.01arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1164747424209747424Rat
619613Bp77Blood pressure QTL 770.01arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)1164747424209747424Rat
1354653Despr9Despair related QTL 90.00019locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)1167909849212909849Rat
61341Bp26Blood pressure QTL 26arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1169537671214537671Rat
724562Rends1Renal damage susceptibility QTL 10.05kidney glomerulus integrity trait (VT:0010546)index of glomerular damage (CMO:0001135)1169537671214537671Rat
1358294Bw37Body weight QTL 3750.000011body mass (VT:0001259)body weight (CMO:0000012)1171310381216310381Rat
2293689Bss47Bone structure and strength QTL 477.250.0001lumbar vertebra size trait (VT:0010518)lumbar vertebra trabecular cross-sectional area (CMO:0001692)1171629477216629477Rat
2293693Bss22Bone structure and strength QTL 2233.520.0001femur morphology trait (VT:0000559)femur cross-sectional area (CMO:0001661)1171629477216629477Rat
2300161Bmd43Bone mineral density QTL 438.40.0001femur mineral mass (VT:0010011)volumetric bone mineral density (CMO:0001553)1171629477216629477Rat
2300174Bmd42Bone mineral density QTL 428.40.0001lumbar vertebra mineral mass (VT:0010511)bone mineral density (CMO:0001226)1171629477216629477Rat
2300187Bmd41Bone mineral density QTL 418.90.0001femur mineral mass (VT:0010011)volumetric bone mineral density (CMO:0001553)1171629477216629477Rat
2293654Bss30Bone structure and strength QTL 3032.650.0001femur strength trait (VT:0010010)femur midshaft polar moment of inertia (CMO:0001669)1171629477216629477Rat
2293673Bss27Bone structure and strength QTL 2718.630.0001femur morphology trait (VT:0000559)femur midshaft cortical cross-sectional area (CMO:0001663)1171629477216629477Rat
2293677Bss41Bone structure and strength QTL 419.380.0001lumbar vertebra size trait (VT:0010518)lumbar vertebra cross-sectional area (CMO:0001689)1171629477216629477Rat
1549830Bss1Bone structure and strength QTL 14.8femur strength trait (VT:0010010)femur ultimate force (CMO:0001675)1172609619217609619Rat
631214Bw61Body weight QTL613.40.0001intramuscular adipose amount (VT:0010044)intramuscular fat area (CMO:0001162)1173108781218108781Rat
70163Bw20Body weight QTL 205.1body mass (VT:0001259)body weight (CMO:0000012)1174133260219133260Rat
738032Hcas5Hepatocarcinoma susceptibility QTL 53.12liver integrity trait (VT:0010547)liver tumorous lesion number (CMO:0001068)1176426412257976495Rat
1600380Niddm70Non-insulin dependent diabetes mellitus QTL 703.10.0008blood insulin amount (VT:0001560)plasma insulin level (CMO:0000342)1176550523221550523Rat
10059600Bp378Blood pressure QTL 3783.080.05arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1176869060221869060Rat
1354624Cm35Cardiac mass QTL355.7heart left ventricle mass (VT:0007031)calculated heart weight (CMO:0000073)1177227632256448636Rat
1354652Kidm20Kidney mass QTL 204.3kidney mass (VT:0002707)calculated kidney weight (CMO:0000160)1177227632256448636Rat
1558658Bw59Body weight QTL 593.50.0003body mass (VT:0001259)body weight (CMO:0000012)1178784622223784622Rat
634321Hc1Hypercalciuria QTL 12.91urine calcium amount (VT:0002985)urine calcium excretion rate (CMO:0000763)1178810256240830002Rat
1578763Kidm29Kidney mass QTL 293.30.0001kidney mass (VT:0002707)both kidneys wet weight (CMO:0000085)1179567751260522016Rat
1302787Stl25Serum triglyceride level QTL 252.70.0073blood triglyceride amount (VT:0002644)plasma triglyceride level (CMO:0000548)1180359209210702199Rat
6903303Scl34Serum cholesterol QTL 342.50.0033blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)1180359209218108781Rat
737977Bp160Blood pressure QTL 1600.001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)1181133855226133855Rat
724559Pancm1Pancreatic morphology QTL 17.1islet of Langerhans morphology trait (VT:0005215)pancreatic islet damage composite score (CMO:0001156)1181759564214537555Rat
2293083Iddm25Insulin dependent diabetes mellitus QTL 254.18blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)1181829673224569684Rat
634312Bp143Blood pressure QTL 14330.0002arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1182623426219932796Rat
8655655Arrd2Age-related retinal degeneration QTL 27.79retinal layer morphology trait (VT:0003727)percentage of study population developing retinopathy during a period of time (CMO:0002453)1183970203243914901Rat
8655855Arrd3Age-related retinal degeneration QTL 33.07lens clarity trait (VT:0001304)cataract incidence/prevalence measurement (CMO:0001585)1183970203243914901Rat
631838Niddm36Non-insulin dependent diabetes mellitus QTL 360.01insulin secretion trait (VT:0003564)calculated pancreatic islet insulin release measurement (CMO:0001217)1184550676229550676Rat
1300145Rf7Renal function QTL 72.96urine creatinine amount (VT:0010540)urine creatinine level (CMO:0000125)1185145134221264292Rat
1359018Hrtrt20Heart rate QTL 203.08heart pumping trait (VT:2000009)heart rate (CMO:0000002)1185356336202902618Rat
2312564Glom18Glomerulus QTL 182.40.003kidney glomerulus morphology trait (VT:0005325)index of glomerular damage (CMO:0001135)1185356336231689108Rat
1582206Kidm33Kidney mass QTL 336.9kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)1188377360224054420Rat
6480780Insul18Insulin level QTL 184.11blood insulin amount (VT:0001560)plasma insulin level (CMO:0000342)1189607473200611765Rat
1358898Bp255Blood pressure QTL 2553.6arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)1191019702246062233Rat
10059590Kidm44Kidney mass QTL 443.420.025kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)1191033875236033875Rat
631260Tcas2Tongue tumor susceptibility QTL 24.93tongue integrity trait (VT:0010553)number of squamous cell tumors of the tongue with diameter greater than 3 mm (CMO:0001950)1192485903199050587Rat
1358191Ept10Estrogen-induced pituitary tumorigenesis QTL 103.8pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)1192825253243914732Rat
8552891Epfw5Epididymal fat weight QTL 54.4epididymal fat pad mass (VT:0010421)epididymal fat pad weight to body weight ratio (CMO:0000658)1193113876238113876Rat
634338Hcar4Hepatocarcinoma resistance QTL 44.6liver integrity trait (VT:0010547)liver tumorous lesion number to liver area ratio (CMO:0001210)1193422268214537671Rat
1600388Niddm67Non-insulin dependent diabetes mellitus QTL 675.840.000004blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)1195804352257091168Rat
1600395Niddm69Non-insulin dependent diabetes mellitus QTL 694.140.0002blood insulin amount (VT:0001560)plasma insulin level (CMO:0000342)1195804352257091168Rat
1600396Niddm68Non-insulin dependent diabetes mellitus QTL 684.970.0003blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)1195804352257091168Rat
631658Cm7Cardiac mass QTL 75.320.0001aorta mass (VT:0002845)aorta weight (CMO:0000076)1196248093241248093Rat
1358292Cm37Cardiac mass QTL 376.20.00000081heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)1196248093241248093Rat
6480777Insul17Insulin level QTL 173.86blood insulin amount (VT:0001560)blood insulin level area under curve (AUC) (CMO:0000351)1197260913198211706Rat
6480783Insul19Insulin level QTL 194.33blood insulin amount (VT:0001560)plasma insulin level (CMO:0000342)1197489281200611765Rat
1600374Mcs17Mammary carcinoma susceptibility QTL 173mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)1197670404242670404Rat
1641926Teswt2Testicular weight QTL 22.82testis mass (VT:1000644)both testes wet weight (CMO:0000175)1197697768238755659Rat
2302375Bw83Body weight QTL 834.870.0002body mass (VT:0001259)body weight (CMO:0000012)1197697768242697768Rat
61376Bp42Blood pressure QTL 4223.4arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1197814409242814409Rat
1298084Thym4Thymus enlargement QTL 410.68thymus mass (VT:0004954)thymus weight to body weight ratio (CMO:0000612)1197814409242814409Rat
1357335Bw39Body weight QTL 393.3body mass (VT:0001259)body weight (CMO:0000012)1197814409242814409Rat

Markers in Region
D1Smu3  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21198,081,083 - 198,081,184 (+)MAPPERmRatBN7.2
Rnor_6.01216,082,612 - 216,082,712NCBIRnor6.0
Rnor_5.01222,945,040 - 222,945,140UniSTSRnor5.0
RGSC_v3.41203,173,831 - 203,173,931UniSTSRGSC3.4
Celera1195,651,528 - 195,651,628UniSTS
Cytogenetic Map1q41UniSTS
M69200  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21198,071,580 - 198,071,684 (+)MAPPERmRatBN7.2
Rnor_6.01216,073,109 - 216,073,212NCBIRnor6.0
Rnor_5.01222,935,537 - 222,935,640UniSTSRnor5.0
RGSC_v3.41203,164,328 - 203,164,431UniSTSRGSC3.4
Celera1195,642,132 - 195,642,235UniSTS
Cytogenetic Map1q41UniSTS
PMC18740P1  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21198,072,757 - 198,073,166 (+)MAPPERmRatBN7.2
Rnor_6.01216,074,286 - 216,074,694NCBIRnor6.0
Rnor_5.01222,936,714 - 222,937,122UniSTSRnor5.0
RGSC_v3.41203,165,505 - 203,165,913UniSTSRGSC3.4
Celera1195,643,309 - 195,643,717UniSTS
Cytogenetic Map1q41UniSTS
RH94698  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21198,076,403 - 198,076,537 (+)MAPPERmRatBN7.2
Rnor_6.01216,077,932 - 216,078,065NCBIRnor6.0
Rnor_5.01222,940,360 - 222,940,493UniSTSRnor5.0
RGSC_v3.41203,169,151 - 203,169,284UniSTSRGSC3.4
Celera1195,646,955 - 195,647,088UniSTS
Cytogenetic Map1q41UniSTS
PMC151031P1  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21198,075,720 - 198,076,641 (+)MAPPERmRatBN7.2
Rnor_6.01216,077,249 - 216,078,169NCBIRnor6.0
Rnor_5.01222,939,677 - 222,940,597UniSTSRnor5.0
RGSC_v3.41203,168,468 - 203,169,388UniSTSRGSC3.4
Celera1195,646,272 - 195,647,192UniSTS
Cytogenetic Map1q41UniSTS
Th  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21198,075,568 - 198,076,698 (+)MAPPERmRatBN7.2
Rnor_6.01216,077,097 - 216,078,226NCBIRnor6.0
Rnor_5.01222,939,525 - 222,940,654UniSTSRnor5.0
RGSC_v3.41203,168,316 - 203,169,445UniSTSRGSC3.4
Celera1195,646,120 - 195,647,249UniSTS
Cytogenetic Map1q41UniSTS


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 8 30 8
Low 2 2 2 2 44 10 16
Below cutoff 1 23 13 7 16 7 3 3 14 14 3 3

Sequence


RefSeq Acc Id: ENSRNOT00000027682   ⟹   ENSRNOP00000027682
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1198,071,503 - 198,078,759 (-)Ensembl
Rnor_6.0 Ensembl1216,073,031 - 216,080,287 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000105945   ⟹   ENSRNOP00000093950
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1198,071,503 - 198,109,767 (-)Ensembl
RefSeq Acc Id: NM_012740   ⟹   NP_036872
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21198,071,506 - 198,078,759 (-)NCBI
Rnor_6.01216,073,034 - 216,080,287 (-)NCBI
Rnor_5.01222,935,462 - 222,942,715 (-)NCBI
RGSC_v3.41203,164,253 - 203,171,506 (-)RGD
Celera1195,642,057 - 195,649,203 (-)RGD
Sequence:
RefSeq Acc Id: XM_039101320   ⟹   XP_038957248
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21198,071,500 - 198,078,829 (-)NCBI
RefSeq Acc Id: XM_039101324   ⟹   XP_038957252
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21198,071,500 - 198,078,832 (-)NCBI
RefSeq Acc Id: XM_039101327   ⟹   XP_038957255
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21198,071,500 - 198,078,829 (-)NCBI
RefSeq Acc Id: NP_036872   ⟸   NM_012740
- UniProtKB: P04177 (UniProtKB/Swiss-Prot),   A6HY86 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSRNOP00000027682   ⟸   ENSRNOT00000027682
RefSeq Acc Id: XP_038957252   ⟸   XM_039101324
- Peptide Label: isoform X2
- UniProtKB: A0A8I6AXT4 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038957255   ⟸   XM_039101327
- Peptide Label: isoform X3
- UniProtKB: A0A8I6AXT4 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038957248   ⟸   XM_039101320
- Peptide Label: isoform X1
RefSeq Acc Id: ENSRNOP00000093950   ⟸   ENSRNOT00000105945
Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P04177-F1-model_v2 AlphaFold P04177 1-498 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:3853 AgrOrtholog
BioCyc Gene G2FUF-56889 BioCyc
BioCyc Pathway PWY66-301 [catecholamine biosynthesis] BioCyc
Ensembl Genes ENSRNOG00000020410 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Ensembl Protein ENSRNOP00000027682 ENTREZGENE, UniProtKB/Swiss-Prot
  ENSRNOP00000093950 ENTREZGENE
  ENSRNOP00000093950.1 UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000027682 ENTREZGENE, UniProtKB/Swiss-Prot
  ENSRNOT00000105945 ENTREZGENE
  ENSRNOT00000105945.1 UniProtKB/TrEMBL
Gene3D-CATH 1.10.800.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  3.30.70.260 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro ACT-like_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ArAA_hydroxylase UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ArAA_hydroxylase_Fe/CU_BS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ArAA_hydroxylase_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Aro-AA_hydroxylase_C_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Aromatic-AA_hydroxylase_C UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Eu_TyrOH_cat UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Tyr_3_mOase UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Tyrosine_3-monooxygenase-like UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Tyrosine_hydroxylase_CS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:25085 UniProtKB/Swiss-Prot
NCBI Gene 25085 ENTREZGENE
PANTHER PTHR11473 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  TYROSINE 3-MONOOXYGENASE UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam Biopterin_H UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  TOH_N UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Th PhenoGen
PIRSF PIRSF000336 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PRINTS FYWHYDRXLASE UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE BH4_AAA_HYDROXYL_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  BH4_AAA_HYDROXYL_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP ACT-like UniProtKB/TrEMBL, UniProtKB/Swiss-Prot
  SSF56534 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
TIGR TC228643
UniProt A0A8I6AXT4 ENTREZGENE, UniProtKB/TrEMBL
  A6HY86 ENTREZGENE, UniProtKB/TrEMBL
  P04177 ENTREZGENE
  P97904_RAT UniProtKB/TrEMBL
  TY3H_RAT UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2002-06-10 Th  Tyrosine hydroxylase      Symbol and Name status set to approved 70586 APPROVED

RGD Curation Notes
Note Type Note Reference
gene_expression basal levels of mRNA is expressed by norepinephrine (NE) and epinephrine neurons,expression is higher in young animals during the steroid induced surge 628385
gene_regulation mRNA levels are regulated by gonadal steroids 628385