Enables several functions, including cation binding activity; tetrahydrobiopterin binding activity; and tyrosine 3-monooxygenase activity. Involved in several processes, including aminergic neurotransmitter loading into synaptic vesicle; carboxylic acid metabolic process; and cellular response to nicotine. Located in several cellular components, including cytoplasmic vesicle; perikaryon; and terminal bouton. Used to study Parkinson's disease. Biomarker of several diseases, including brain disease (multiple); hyperprolactinemia; polycystic ovary syndrome; portal hypertension; and uremia. Human ortholog(s) of this gene implicated in Parkinson's disease; Parkinsonism; hypertension; and obesity. Orthologous to human TH (tyrosine hydroxylase); PARTICIPATES IN aromatic L-amino acid decarboxylase deficiency pathway; catecholamine biosynthetic pathway; dopamine biosynthetic pathway; INTERACTS WITH "2',5'-Dideoxyadenosine"; (+)-catechin; (+)-sesamin.
[Clonidine results in decreased activity of and results in decreased expression of TH protein] which results in decreased abundance of Norepinephrine, [Clonidine results in increased expression of TH protein] which results in increased abundance of Norepinephrine
[Ascorbic Acid co-treated with alpha-Tocopherol co-treated with Acetylcysteine] results in decreased expression of TH protein, alpha-Tocopherol inhibits the reaction [Rotenone results in decreased expression of TH protein]
1-naphthylacetylspermine inhibits the reaction [alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid results in decreased expression of TH protein], aminophenyl fluorescein inhibits the reaction [alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid results in decreased expression of TH protein]
[conotoxin AuIB co-treated with triethyl-(beta-4-stilbenoxyethyl)ammonium co-treated with ZM 241385] inhibits the reaction [imidacloprid promotes the reaction [Nicotine results in increased expression of TH mRNA]] more ...
[methyllycaconitine binds to and results in decreased activity of CHRNA7 protein] inhibits the reaction [Nicotine results in increased expression of TH mRNA]
1-naphthylacetylspermine inhibits the reaction [alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid results in decreased expression of TH protein]
Estradiol inhibits the reaction [manganese chloride results in decreased expression of TH mRNA], Estradiol inhibits the reaction [manganese chloride results in decreased expression of TH protein]
Estradiol promotes the reaction [ESR2 protein affects the expression of TH mRNA], Estradiol results in increased expression of and results in increased secretion of TH protein
[bisphenol A co-treated with Diethylhexyl Phthalate] inhibits the reaction [Tetrachlorodibenzodioxin results in decreased expression of TH protein] more ...
6-methyl-2-(phenylethynyl)pyridine affects the reaction [[GOPC protein affects the susceptibility to Oxidopamine] which affects the expression of TH protein]
[GW 1929 co-treated with Mercaptopurine] inhibits the reaction [1-Methyl-4-phenylpyridinium results in decreased expression of TH protein], Mercaptopurine inhibits the reaction [1-Methyl-4-phenylpyridinium results in decreased expression of TH protein]
3-Hydroxybutyric Acid affects the reaction [ZFP36 protein affects the reaction [1-Methyl-4-phenylpyridinium results in decreased expression of TH protein]] more ...
3-methyladenine inhibits the reaction [fenvalerate results in decreased expression of TH protein], 3-methyladenine inhibits the reaction [Oxidopamine results in decreased expression of TH protein]
8-bromocyclic GMP inhibits the reaction [[EDN1 protein binds to and results in increased activity of EDNRB protein] which results in decreased activity of TH protein], 8-bromocyclic GMP inhibits the reaction [[EDN3 protein binds to and results in increased activity of EDNRB protein] which results in decreased activity of TH protein]
Tamoxifen inhibits the reaction [amitraz results in increased expression of TH mRNA], Tamoxifen inhibits the reaction [amitraz results in increased expression of TH protein]
[aroclor 1242 co-treated with aroclor 1248 co-treated with Chlorodiphenyl (54% Chlorine) co-treated with aroclor 1260] results in decreased expression of TH protein, [Chlorodiphenyl (54% Chlorine) co-treated with aroclor 1242 co-treated with aroclor 1248] results in decreased expression of TH mRNA
Bicuculline promotes the reaction [Reserpine affects the activity of TH protein], Bicuculline promotes the reaction [Reserpine results in increased expression of TH mRNA]
[bisphenol A co-treated with Diethylhexyl Phthalate] inhibits the reaction [Tetrachlorodibenzodioxin results in decreased expression of TH protein] more ...
IGF1 protein inhibits the reaction [bisphenol A results in decreased expression of TH mRNA], IGF1 protein inhibits the reaction [bisphenol A results in decreased expression of TH protein]
[bisphenol A co-treated with Diethylhexyl Phthalate] inhibits the reaction [Tetrachlorodibenzodioxin results in decreased expression of TH protein] more ...
cyclo(Trp-Asp-Pro-Val-Leu) inhibits the reaction [EDN1 protein results in increased activity of TH protein], cyclo(Trp-Asp-Pro-Val-Leu) inhibits the reaction [EDN1 protein results in increased expression of TH mRNA]
[Plasticizers co-treated with Fungicides, Industrial co-treated with Linuron co-treated with enzacamene co-treated with octylmethoxycinnamate co-treated with Dichlorodiphenyl Dichloroethylene co-treated with butylparaben co-treated with Acetaminophen] results in decreased expression of TH mRNA
[Calcitriol co-treated with VDR protein] results in increased expression of TH mRNA, [Calcitriol co-treated with VDR protein] results in increased expression of TH protein
Chlorisondamine inhibits the reaction [Reserpine results in increased expression of TH mRNA], Chlorisondamine promotes the reaction [Reserpine results in increased expression of TH mRNA]
acetovanillone analog inhibits the reaction [Chlorpyrifos results in decreased expression of TH protein], Acetylcysteine inhibits the reaction [Chlorpyrifos results in decreased expression of TH protein]
[Clonidine results in decreased activity of and results in decreased expression of TH protein] which results in decreased abundance of Dopamine more ...
[Clonidine results in decreased activity of and results in decreased expression of TH protein] which results in decreased abundance of Dopamine more ...
[Clonidine results in decreased activity of and results in decreased expression of TH protein] which results in decreased abundance of Dopamine more ...
Cocaine promotes the reaction [[DRD2 protein results in increased phosphorylation of TH protein] which results in increased abundance of Dopamine], Spiperone inhibits the reaction [Cocaine promotes the reaction [[DRD2 protein results in increased phosphorylation of TH protein] which results in increased abundance of Dopamine]]
[Copper Sulfate results in increased abundance of Copper] which results in decreased expression of TH protein, Copper Sulfate inhibits the reaction [1-Methyl-4-phenylpyridinium results in decreased activity of TH protein]
[Curcumin co-treated with Chitosan analog] inhibits the reaction [Arsenic results in decreased expression of TH protein], Curcumin inhibits the reaction [sodium arsenite results in decreased expression of TH protein]
[Plasticizers co-treated with Fungicides, Industrial co-treated with Linuron co-treated with enzacamene co-treated with octylmethoxycinnamate co-treated with Dichlorodiphenyl Dichloroethylene co-treated with butylparaben co-treated with Acetaminophen] results in decreased expression of TH mRNA
[Plasticizers co-treated with Fungicides, Industrial co-treated with Linuron co-treated with enzacamene co-treated with octylmethoxycinnamate co-treated with Dichlorodiphenyl Dichloroethylene co-treated with butylparaben co-treated with Acetaminophen] results in decreased expression of TH mRNA
Ethanol promotes the reaction [[manganese chloride results in increased abundance of Manganese] which results in decreased expression of TH protein], Ethanol promotes the reaction [mephedrone results in decreased expression of TH protein]
3-methyladenine inhibits the reaction [fenvalerate results in decreased expression of TH protein], SB 203580 inhibits the reaction [fenvalerate results in decreased expression of TH protein]
[GW 1929 co-treated with Mercaptopurine] inhibits the reaction [1-Methyl-4-phenylpyridinium results in decreased expression of TH protein], GW 1929 inhibits the reaction [1-Methyl-4-phenylpyridinium results in decreased expression of TH protein]
[conotoxin AuIB co-treated with triethyl-(beta-4-stilbenoxyethyl)ammonium co-treated with ZM 241385] inhibits the reaction [imidacloprid promotes the reaction [Nicotine results in increased expression of TH mRNA]] more ...
KT 5720 inhibits the reaction [Colforsin results in increased expression of TH mRNA], KT 5720 inhibits the reaction [HU 211 results in decreased expression of TH mRNA]
[Plasticizers co-treated with Fungicides, Industrial co-treated with Linuron co-treated with enzacamene co-treated with octylmethoxycinnamate co-treated with Dichlorodiphenyl Dichloroethylene co-treated with butylparaben co-treated with Acetaminophen] results in decreased expression of TH mRNA
[Tetrachlorodibenzodioxin co-treated with Lipopolysaccharides] results in decreased methylation of TH gene, VCE-003 analog inhibits the reaction [Lipopolysaccharides results in decreased expression of TH protein]
4-(4-fluorophenyl)-2-(4-hydroxyphenyl)-5-(4-pyridyl)imidazole inhibits the reaction [[Paraquat co-treated with Maneb] results in increased expression of TH protein] more ...
[manganese chloride results in increased abundance of Manganese] which results in decreased expression of TH protein, Ethanol promotes the reaction [[manganese chloride results in increased abundance of Manganese] which results in decreased expression of TH protein]
[manganese chloride results in increased abundance of Manganese] which results in decreased expression of TH protein, Ethanol promotes the reaction [[manganese chloride results in increased abundance of Manganese] which results in decreased expression of TH protein]
Melatonin inhibits the reaction [Methamphetamine results in decreased expression of TH protein], Melatonin inhibits the reaction [Rotenone results in decreased expression of TH protein]
[GW 1929 co-treated with Mercaptopurine] inhibits the reaction [1-Methyl-4-phenylpyridinium results in decreased expression of TH protein], Mercaptopurine inhibits the reaction [1-Methyl-4-phenylpyridinium results in decreased expression of TH protein]
[methyllycaconitine binds to and results in decreased activity of CHRNA7 protein] inhibits the reaction [Nicotine results in increased expression of TH mRNA]
[CP 154526 binds to and results in decreased activity of CRHR1 protein] inhibits the reaction [Morphine deficiency results in increased phosphorylation of TH protein] more ...
[Morphine co-treated with Naloxone] results in increased phosphorylation of TH protein, CRHR1 gene mutant form inhibits the reaction [[Morphine co-treated with Naloxone] results in increased phosphorylation of TH protein]
[Ascorbic Acid co-treated with alpha-Tocopherol co-treated with Acetylcysteine] results in decreased expression of TH protein, Acetylcysteine inhibits the reaction [Chlorpyrifos results in decreased expression of TH protein]
3-Hydroxybutyric Acid affects the reaction [ZFP36 protein affects the reaction [1-Methyl-4-phenylpyridinium results in decreased expression of TH protein]] more ...
[CP 154526 binds to and results in decreased activity of CRHR1 protein] inhibits the reaction [Naloxone results in increased phosphorylation of TH protein], [Morphine co-treated with Naloxone] results in increased phosphorylation of TH protein
[Morphine co-treated with Naloxone] results in increased phosphorylation of TH protein, CRHR1 gene mutant form inhibits the reaction [[Morphine co-treated with Naloxone] results in increased phosphorylation of TH protein]
[conotoxin AuIB co-treated with triethyl-(beta-4-stilbenoxyethyl)ammonium co-treated with ZM 241385] inhibits the reaction [imidacloprid promotes the reaction [Nicotine results in increased expression of TH mRNA]] more ...
[methyllycaconitine binds to and results in decreased activity of CHRNA7 protein] inhibits the reaction [Nicotine results in increased expression of TH mRNA]
2-chloro-5-hydroxyphenylglycine affects the reaction [[GOPC protein affects the susceptibility to Oxidopamine] which affects the expression of TH protein] more ...
[Plasticizers co-treated with Fungicides, Industrial co-treated with Linuron co-treated with enzacamene co-treated with octylmethoxycinnamate co-treated with Dichlorodiphenyl Dichloroethylene co-treated with butylparaben co-treated with Acetaminophen] results in decreased expression of TH mRNA
4-(4-fluorophenyl)-2-(4-hydroxyphenyl)-5-(4-pyridyl)imidazole inhibits the reaction [[Paraquat co-treated with Maneb] results in increased expression of TH protein] more ...
[perfluoro-n-nonanoic acid co-treated with perfluorodecanoic acid co-treated with perfluoroundecanoic acid co-treated with perfluorododecanoic acid co-treated with perfluorooctanoic acid co-treated with perfluorooctane sulfonic acid] results in decreased expression of TH mRNA
[perfluoro-n-nonanoic acid co-treated with perfluorodecanoic acid co-treated with perfluoroundecanoic acid co-treated with perfluorododecanoic acid co-treated with perfluorooctanoic acid co-treated with perfluorooctane sulfonic acid] results in decreased expression of TH mRNA
[perfluoro-n-nonanoic acid co-treated with perfluorodecanoic acid co-treated with perfluoroundecanoic acid co-treated with perfluorododecanoic acid co-treated with perfluorooctanoic acid co-treated with perfluorooctane sulfonic acid] results in decreased expression of TH mRNA
[perfluoro-n-nonanoic acid co-treated with perfluorodecanoic acid co-treated with perfluoroundecanoic acid co-treated with perfluorododecanoic acid co-treated with perfluorooctanoic acid co-treated with perfluorooctane sulfonic acid] results in decreased expression of TH mRNA
[perfluoro-n-nonanoic acid co-treated with perfluorodecanoic acid co-treated with perfluoroundecanoic acid co-treated with perfluorododecanoic acid co-treated with perfluorooctanoic acid co-treated with perfluorooctane sulfonic acid] results in decreased expression of TH mRNA
[perfluoro-n-nonanoic acid co-treated with perfluorodecanoic acid co-treated with perfluoroundecanoic acid co-treated with perfluorododecanoic acid co-treated with perfluorooctanoic acid co-treated with perfluorooctane sulfonic acid] results in decreased expression of TH mRNA
[GW 1929 co-treated with Mercaptopurine] inhibits the reaction [1-Methyl-4-phenylpyridinium results in decreased expression of TH protein], Mercaptopurine inhibits the reaction [1-Methyl-4-phenylpyridinium results in decreased expression of TH protein]
pyrrolidine dithiocarbamic acid affects the reaction [GPX1 protein affects the reaction [Methamphetamine results in decreased expression of and results in decreased activity of TH protein]], pyrrolidine dithiocarbamic acid inhibits the reaction [Methamphetamine results in decreased expression of and results in decreased activity of TH protein]
Quercetin inhibits the reaction [Rotenone results in decreased activity of TH protein], Quercetin inhibits the reaction [Rotenone results in decreased expression of TH protein]
Rimonabant affects the reaction [PRKN mutant form affects the activity of TH protein], Rimonabant inhibits the reaction [Dronabinol results in increased activity of TH protein]
1-trifluoromethoxyphenyl-3-(1-propionylpiperidine-4-yl)urea inhibits the reaction [Docosahexaenoic Acids inhibits the reaction [Rotenone results in decreased expression of TH protein]] more ...
[rottlerin results in decreased activity of PRKCD protein] inhibits the reaction [Methamphetamine results in decreased activity of TH protein], [rottlerin results in decreased activity of PRKCD protein] inhibits the reaction [Methamphetamine results in decreased expression of TH protein]
SB 203580 inhibits the reaction [fenvalerate results in decreased expression of TH protein], SB 203580 inhibits the reaction [sodium arsenite results in increased phosphorylation of and results in increased activity of TH protein]
SCH 23390 inhibits the reaction [1-(2-thienyl)-2-(methylamino)propane results in decreased expression of TH protein], SCH 23390 inhibits the reaction [Methamphetamine results in decreased expression of TH protein]
Spiperone inhibits the reaction [Cocaine promotes the reaction [[DRD2 protein results in increased phosphorylation of TH protein] which results in increased abundance of Dopamine]]
[Streptozocin co-treated with Dietary Fats] results in increased expression of TH protein, Metformin inhibits the reaction [[Streptozocin co-treated with Dietary Fats] results in increased expression of TH protein]
Sulpiride inhibits the reaction [Dopamine results in decreased activity of TH protein], Sulpiride inhibits the reaction [Rotenone results in decreased expression of TH protein]
Tamoxifen inhibits the reaction [manganese chloride results in decreased expression of TH mRNA], Tamoxifen inhibits the reaction [manganese chloride results in decreased expression of TH protein]
Tamoxifen inhibits the reaction [amitraz results in increased expression of TH mRNA], Tamoxifen inhibits the reaction [amitraz results in increased expression of TH protein]
Valproic Acid inhibits the reaction [manganese chloride results in decreased expression of TH mRNA], Valproic Acid inhibits the reaction [manganese chloride results in decreased expression of TH protein]
CREB1 protein affects the reaction [Valproic Acid results in increased expression of TH mRNA], Valproic Acid inhibits the reaction [Methamphetamine results in decreased expression of TH protein]
Paraquat promotes the reaction [Zinc Sulfate results in decreased expression of TH protein], Zinc Sulfate promotes the reaction [Paraquat results in decreased expression of TH protein]
Increasing proportions of tyrosine hydroxylase-immunoreactive interneurons colocalize with choline acetyltransferase or vasoactive intestinal peptide in the developing rat cerebral cortex.
Evaluation of anti-Fas ligand-induced apoptosis and neural differentiation of PC12 cells treated with nerve growth factor using small interfering RNA method and sampling by microdialysis.
Behavioral recovery in 6-hydroxydopamine-lesioned rats by cotransduction of striatum with tyrosine hydroxylase and aromatic L-amino acid decarboxylase genes using two separate adeno-associated virus vectors.
Effects of insulin treatment without and with recurrent hypoglycemia on hypoglycemic counterregulation and adrenal catecholamine-synthesizing enzymes in diabetic rats.
Influences of dopaminergic lesion on epidermal growth factor-ErbB signals in Parkinson's disease and its model: neurotrophic implication in nigrostriatal neurons.
Anti-stress effects of ginseng via down-regulation of tyrosine hydroxylase (TH) and dopamine beta-hydroxylase (DBH) gene expression in immobilization-stressed rats and PC12 cells.
DNA polymorphisms in the tyrosine hydroxylase and GNB3 genes: association with unexpected death from acute myocardial infarction and increased heart weight.
Long-term gonadectomy affects the density of tyrosine hydroxylase- but not dopamine-beta-hydroxylase-, choline acetyltransferase- or serotonin-immunoreactive axons in the medial prefrontal cortices of adult male rats.
Effect of zinc and paraquat co-exposure on neurodegeneration: Modulation of oxidative stress and expression of metallothioneins, toxicant responsive and transporter genes in rats.
Prenatal morphine exposure affects sympathoadrenal axis activity and serotonin metabolism in adult male rats both under basal conditions and after an ether inhalation stress.
Time course analysis of tyrosine hydroxylase and angiotensinogen mRNA expression in central nervous system of rats submitted to experimental hypertension.
Profound changes in dopaminergic neurotransmission in the prefrontal cortex in response to flattening of the diurnal glucocorticoid rhythm: implications for bipolar disorder.
Developmental expression of delta-opioid receptors during maturation of the parasympathetic, sympathetic, and sensory innervations of the neonatal heart: early targets for opioid regulation of autonomic control.
Coexpression of tyrosine hydroxylase, GTP cyclohydrolase I, aromatic amino acid decarboxylase, and vesicular monoamine transporter 2 from a helper virus-free herpes simplex virus type 1 vector supports high-level, long-term biochemical and behavioral correction of a rat model of Parkinson's disease.
Expression of estrogen receptor-alpha and cFos in norepinephrine and epinephrine neurons of young and middle-aged rats during the steroid-induced luteinizing hormone surge.
Protein kinase C delta negatively regulates tyrosine hydroxylase activity and dopamine synthesis by enhancing protein phosphatase-2A activity in dopaminergic neurons.
Activation of cerebral peroxisome proliferator - activated receptors gamma (PPARgamma) reduces neuronal damage in the substantia nigra after transient focal cerebral ischaemia in the rat.
basal levels of mRNA is expressed by norepinephrine (NE) and epinephrine neurons,expression is higher in young animals during the steroid induced surge
