Stx1b (syntaxin 1B) - Rat Genome Database

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Gene: Stx1b (syntaxin 1B) Rattus norvegicus
Analyze
Symbol: Stx1b
Name: syntaxin 1B
RGD ID: 3784
Description: Enables protein domain specific binding activity and signaling receptor binding activity. Involved in protein localization to membrane; regulation of exocytosis; and vesicle-mediated transport. Located in presynaptic membrane. Human ortholog(s) of this gene implicated in generalized epilepsy with febrile seizures plus 9. Orthologous to human STX1B (syntaxin 1B); INTERACTS WITH (S)-amphetamine; 2,3,7,8-tetrachlorodibenzodioxine; 2,3,7,8-Tetrachlorodibenzofuran.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: P35B; Stx1b2; Stx2; syntaxin 1B2; Syntaxin 2; syntaxin-1B; syntaxin-1B2
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81191,846,016 - 191,864,878 (-)NCBIGRCr8
mRatBN7.21182,415,544 - 182,434,385 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1182,415,546 - 182,441,280 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1190,768,540 - 190,784,704 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01197,954,630 - 197,970,797 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01190,625,066 - 190,641,183 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01199,251,842 - 199,270,465 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1199,251,844 - 199,270,627 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01206,276,724 - 206,292,888 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41187,092,014 - 187,108,481 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11187,239,062 - 187,258,524 (-)NCBI
Celera1180,069,042 - 180,085,214 (-)NCBICelera
Cytogenetic Map1q37NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Role of SNAP-23 in trafficking of H+-ATPase in cultured inner medullary collecting duct cells. Banerjee A, etal., Am J Physiol Cell Physiol. 2001 Apr;280(4):C775-81.
2. Direct interaction of the rat unc-13 homologue Munc13-1 with the N terminus of syntaxin. Betz A, etal., J Biol Chem. 1997 Jan 24;272(4):2520-6.
3. Staring, a novel E3 ubiquitin-protein ligase that targets syntaxin 1 for degradation. Chin LS, etal., J Biol Chem 2002 Sep 20;277(38):35071-9.
4. The secretory granule protein syncollin binds to syntaxin in a Ca2(+)-sensitive manner. Edwardson JM, etal., Cell 1997 Jul 25;90(2):325-33.
5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
6. Differential vesicular sorting of AMPA and GABAA receptors. Gu Y, etal., Proc Natl Acad Sci U S A. 2016 Feb 16;113(7):E922-31. doi: 10.1073/pnas.1525726113. Epub 2016 Feb 2.
7. A novel ubiquitous form of Munc-18 interacts with multiple syntaxins. Use of the yeast two-hybrid system to study interactions between proteins involved in membrane traffic. Hata Y and Sudhof TC, J Biol Chem 1995 Jun 2;270(22):13022-8.
8. SNAREs are concentrated in cholesterol-dependent clusters that define docking and fusion sites for exocytosis. Lang T, etal., EMBO J 2001 May 1;20(9):2202-13.
9. Ca(2+)-dependent and -independent activities of neural and non-neural synaptotagmins. Li C, etal., Nature 1995 Jun 15;375(6532):594-9.
10. Retinal pigment epithelial cells exhibit unique expression and localization of plasma membrane syntaxins which may contribute to their trafficking phenotype. Low SH, etal., J Cell Sci 2002 Dec 1;115(Pt 23):4545-53.
11. Label-free mass spectrometric analysis reveals complex changes in the brain proteome from the mdx-4cv mouse model of Duchenne muscular dystrophy. Murphy S, etal., Clin Proteomics. 2015 Nov 23;12:27. doi: 10.1186/s12014-015-9099-0. eCollection 2015.
12. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
13. Munc 18a binding to syntaxin 1A and 1B isoforms defines its localization at the plasma membrane and blocks SNARE assembly in a three-hybrid system assay. Perez-Branguli F, etal., Mol Cell Neurosci 2002 Jun;20(2):169-80.
14. GOA pipeline RGD automated data pipeline
15. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
16. Inositol 1, 4, 5-trisphosphate receptor interacts with the SNARE domain of syntaxin 1B. Tanaka S, etal., J Physiol Sci. 2011 May;61(3):221-9. doi: 10.1007/s12576-011-0140-4. Epub 2011 Mar 20.
17. Tentative Sequence Identification Numbers Tentative Sequence Data IDs. TIGR Gene Index, Rat Data
18. Transcriptome analysis of frontal cortex in alcohol-preferring and nonpreferring rats. Worst TJ, etal., J Neurosci Res 2005 May 15;80(4):529-38.
Additional References at PubMed
PMID:1321498   PMID:7690687   PMID:8108429   PMID:10468580   PMID:10825299   PMID:12692561   PMID:15035620   PMID:15943887   PMID:16186111   PMID:18691641   PMID:18703708   PMID:21307259  
PMID:21401123   PMID:22871113   PMID:23821748   PMID:24133272   PMID:24587181   PMID:27466336   PMID:29476059  


Genomics

Comparative Map Data
Stx1b
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81191,846,016 - 191,864,878 (-)NCBIGRCr8
mRatBN7.21182,415,544 - 182,434,385 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1182,415,546 - 182,441,280 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1190,768,540 - 190,784,704 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01197,954,630 - 197,970,797 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01190,625,066 - 190,641,183 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01199,251,842 - 199,270,465 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1199,251,844 - 199,270,627 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01206,276,724 - 206,292,888 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41187,092,014 - 187,108,481 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11187,239,062 - 187,258,524 (-)NCBI
Celera1180,069,042 - 180,085,214 (-)NCBICelera
Cytogenetic Map1q37NCBI
STX1B
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381630,989,256 - 31,010,638 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1630,989,256 - 31,010,638 (-)EnsemblGRCh38hg38GRCh38
GRCh371631,000,577 - 31,021,959 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361630,910,869 - 30,929,276 (-)NCBINCBI36Build 36hg18NCBI36
Build 341630,910,868 - 30,929,276NCBI
Celera1629,275,546 - 29,296,879 (+)NCBICelera
Cytogenetic Map16p11.2NCBI
HuRef1628,563,033 - 28,574,857 (-)NCBIHuRef
CHM1_11632,317,577 - 32,338,829 (-)NCBICHM1_1
T2T-CHM13v2.01631,376,698 - 31,398,083 (-)NCBIT2T-CHM13v2.0
Stx1b
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm397127,403,072 - 127,423,703 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl7127,403,072 - 127,423,721 (-)EnsemblGRCm39 Ensembl
GRCm387127,803,900 - 127,824,531 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl7127,803,900 - 127,824,549 (-)EnsemblGRCm38mm10GRCm38
MGSCv377134,950,358 - 134,968,045 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv367127,598,364 - 127,615,438 (-)NCBIMGSCv36mm8
Celera7127,641,815 - 127,659,486 (-)NCBICelera
Cytogenetic Map7F3NCBI
cM Map769.75NCBI
Stx1b
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554937,838,684 - 7,857,700 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049554937,838,684 - 7,857,700 (-)NCBIChiLan1.0ChiLan1.0
STX1B
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21834,195,264 - 34,218,552 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11638,996,671 - 39,019,969 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01623,956,426 - 23,979,646 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11631,356,907 - 31,378,864 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1631,356,907 - 31,378,870 (-)Ensemblpanpan1.1panPan2
STX1B
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1617,209,972 - 17,219,903 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl617,210,433 - 17,241,363 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha618,777,682 - 18,795,209 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0617,332,948 - 17,350,471 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl617,333,052 - 17,350,471 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1617,133,312 - 17,150,823 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0617,052,453 - 17,069,975 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0617,364,988 - 17,382,509 (+)NCBIUU_Cfam_GSD_1.0
Stx1b
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024409344125,272,960 - 125,280,193 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493650113,370,452 - 13,378,120 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_00493650113,370,678 - 13,378,933 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
STX1A
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl310,974,127 - 10,991,873 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1310,974,127 - 10,991,846 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2310,670,296 - 10,688,032 (-)NCBISscrofa10.2Sscrofa10.2susScr3
STX1B
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1527,683,526 - 27,702,032 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl527,684,082 - 27,694,814 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_0236660681,769,965 - 1,788,800 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Stx1b
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462478214,057,346 - 14,073,911 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462478214,054,762 - 14,073,890 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Stx1b
72 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:441
Count of miRNA genes:207
Interacting mature miRNAs:264
Transcripts:ENSRNOT00000026063
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1578778Pur4Proteinuria QTL 43.30.003urine total protein amount (VT:0000032)urine total protein excretion rate (CMO:0000756)1150700247252085048Rat
1354646Kidm18Kidney mass QTL 185.7kidney mass (VT:0002707)calculated kidney weight (CMO:0000160)1151162512256448636Rat
1578780Cm52Cardiac mass QTL 523.30.0001heart mass (VT:0007028)heart wet weight (CMO:0000069)181591954219808434Rat
1354652Kidm20Kidney mass QTL 204.3kidney mass (VT:0002707)calculated kidney weight (CMO:0000160)1177227632256448636Rat
2302378Insul11Insulin level QTL 113.25blood insulin amount (VT:0001560)serum insulin level (CMO:0000358)1144267353251128347Rat
1354653Despr9Despair related QTL 90.00019locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)1167909849212909849Rat
1578770Stresp23Stress response QTL 23kidney sympathetic nerve activity (VT:0004050)stimulated renal sympathetic nerve activity to basal renal sympathetic nerve activity ratio (CMO:0001786)1123350408182418476Rat
2293673Bss27Bone structure and strength QTL 2718.630.0001femur morphology trait (VT:0000559)femur midshaft cortical cross-sectional area (CMO:0001663)1171629477216629477Rat
2293677Bss41Bone structure and strength QTL 419.380.0001lumbar vertebra size trait (VT:0010518)lumbar vertebra cross-sectional area (CMO:0001689)1171629477216629477Rat
1302787Stl25Serum triglyceride level QTL 252.70.0073blood triglyceride amount (VT:0002644)plasma triglyceride level (CMO:0000548)1180359209210702199Rat
70160Bw18Body weight QTL 185.7body mass (VT:0001259)body weight (CMO:0000012)1144267353196383668Rat
1549830Bss1Bone structure and strength QTL 14.8femur strength trait (VT:0010010)femur ultimate force (CMO:0001675)1172609619217609619Rat
7794788Mcs32Mammary carcinoma susceptibility QTL 322.61mammary gland integrity trait (VT:0010552)mammary tumor incidence/prevalence measurement (CMO:0000946)1115540693238914717Rat
70163Bw20Body weight QTL 205.1body mass (VT:0001259)body weight (CMO:0000012)1174133260219133260Rat
1578763Kidm29Kidney mass QTL 293.30.0001kidney mass (VT:0002707)both kidneys wet weight (CMO:0000085)1179567751260522016Rat
1354624Cm35Cardiac mass QTL355.7heart left ventricle mass (VT:0007031)calculated heart weight (CMO:0000073)1177227632256448636Rat
1558658Bw59Body weight QTL 593.50.0003body mass (VT:0001259)body weight (CMO:0000012)1178784622223784622Rat
1354636Lmblg1Limb length QTL 16.4tibia length (VT:0004357)tibia length (CMO:0000450)1151162512201278233Rat
1549837Hcar15Hepatocarcinoma resistance QTL 150.05liver integrity trait (VT:0010547)liver tumorous lesion number (CMO:0001068)1153136852260522016Rat
2293689Bss47Bone structure and strength QTL 477.250.0001lumbar vertebra size trait (VT:0010518)lumbar vertebra trabecular cross-sectional area (CMO:0001692)1171629477216629477Rat
1598853Memor3Memory QTL 34.5exploratory behavior trait (VT:0010471)total horizontal distance resulting from voluntary locomotion in an experimental apparatus (CMO:0001443)1143506580212458660Rat
61341Bp26Blood pressure QTL 26arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1169537671214537671Rat
1354634Kidm12Kidney mass QTL 123.9kidney mass (VT:0002707)right kidney wet weight (CMO:0000082)1151162512201278233Rat
4889428Stresp24Stress response QTL 240.05heart pumping trait (VT:2000009)absolute change in electrocardiographic low frequency R-R spectral component to high frequency R-R spectral component ratio (CMO:0002162)1155866514200866514Rat
1578759Uae30Urinary albumin excretion QTL 303.30.003urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)1150700247252085048Rat
61343Bp28Blood pressure QTL 28arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1151646613196646613Rat
2293693Bss22Bone structure and strength QTL 2233.520.0001femur morphology trait (VT:0000559)femur cross-sectional area (CMO:0001661)1171629477216629477Rat
2300161Bmd43Bone mineral density QTL 438.40.0001femur mineral mass (VT:0010011)volumetric bone mineral density (CMO:0001553)1171629477216629477Rat
61347Bp197Blood pressure QTL 1974.2arterial blood pressure trait (VT:2000000)blood pressure measurement (CMO:0000003)1158633083203633083Rat
61348Bp30Blood pressure QTL 302.4arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1144017057197814409Rat
8655649Arrd1Age-related retinal degeneration QTL 14.89retinal layer morphology trait (VT:0003727)percentage of study population developing retinopathy during a period of time (CMO:0002453)1100357752183970443Rat
2303622Vencon6Ventilatory control QTL 60.001respiration trait (VT:0001943)respiration rate (CMO:0000289)1154561505199561505Rat
631214Bw61Body weight QTL613.40.0001intramuscular adipose amount (VT:0010044)intramuscular fat area (CMO:0001162)1173108781218108781Rat
7771612Cm80Cardiac mass QTL 808.4heart left ventricle mass (VT:0007031)heart left ventricle weight (CMO:0000776)1149448574221264292Rat
731168Bp154Blood pressure QTL 1543.4arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)194642644214537671Rat
631205Bp196Blood pressure QTL 19640.0001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)1118944897199050459Rat
1300158Bp173Blood pressure QTL 1733.48arterial blood pressure trait (VT:2000000)blood pressure time series experimental set point of the baroreceptor response (CMO:0002593)1115540693185145286Rat
2300174Bmd42Bone mineral density QTL 428.40.0001lumbar vertebra mineral mass (VT:0010511)bone mineral density (CMO:0001226)1171629477216629477Rat
737828Hcas3Hepatocarcinoma susceptibility QTL 34.9liver integrity trait (VT:0010547)liver tumorous lesion volume to total liver volume ratio (CMO:0001082)1144267353222987745Rat
1331749Hrtrt11Heart rate QTL 112.973heart pumping trait (VT:2000009)heart rate (CMO:0000002)194494440198211706Rat
1354661Bw33Body weight QTL 335.2body mass (VT:0001259)body weight (CMO:0000012)1151162512256448636Rat
1358886Bp260Blood pressure QTL 2603.67arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)1151162766225824951Rat
737977Bp160Blood pressure QTL 1600.001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)1181133855226133855Rat
2293654Bss30Bone structure and strength QTL 3032.650.0001femur strength trait (VT:0010010)femur midshaft polar moment of inertia (CMO:0001669)1171629477216629477Rat
724531Uae5Urinary albumin excretion QTL 54urine albumin amount (VT:0002871)urine albumin level (CMO:0000130)1150700142252085212Rat
2300187Bmd41Bone mineral density QTL 418.90.0001femur mineral mass (VT:0010011)volumetric bone mineral density (CMO:0001553)1171629477216629477Rat
1641895Bp298Blood pressure QTL 298arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)1123350408182418476Rat
70209Niddm23Non-insulin dependent diabetes mellitus QTL 232.82blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)194494440198324465Rat
1354580Scort1Serum corticosterone level QTL 13.4blood corticosterone amount (VT:0005345)blood corticosterone level (CMO:0001172)1156677124256448636Rat
1358294Bw37Body weight QTL 3750.000011body mass (VT:0001259)body weight (CMO:0000012)1171310381216310381Rat
61378Bp43Blood pressure QTL 4322.6arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1181746937196383668Rat
634314Niddm44Non-insulin dependent diabetes mellitus QTL 44blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)149393289199050459Rat
724559Pancm1Pancreatic morphology QTL 17.1islet of Langerhans morphology trait (VT:0005215)pancreatic islet damage composite score (CMO:0001156)1181759564214537555Rat
2312420Pur17Proteinuria QTL 177.10.0001urine protein amount (VT:0005160)urine total protein excretion rate (CMO:0000756)1156677124218753816Rat
10059600Bp378Blood pressure QTL 3783.080.05arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1176869060221869060Rat
1354591Cm36Cardiac mass QTL 364.1heart left ventricle mass (VT:0007031)calculated heart weight (CMO:0000073)1102813953201278233Rat
2312558Glom17Glomerulus QTL 173.90.001kidney glomerulus morphology trait (VT:0005325)index of glomerular damage (CMO:0001135)1166532971191278129Rat
7421630Bp362Blood pressure QTL 3620.001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)1118608292241799120Rat
10059597Bp377Blood pressure QTL 3773.420.025arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)132737458199368955Rat
619613Bp77Blood pressure QTL 770.01arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)1164747424209747424Rat
619614Bp78Blood pressure QTL 780.001arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)1169112897197261052Rat
634321Hc1Hypercalciuria QTL 12.91urine calcium amount (VT:0002985)urine calcium excretion rate (CMO:0000763)1178810256240830002Rat
724562Rends1Renal damage susceptibility QTL 10.05kidney glomerulus integrity trait (VT:0010546)index of glomerular damage (CMO:0001135)1169537671214537671Rat
2292222Bp307Blood pressure QTL 3073.060.0014arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1164310393213533942Rat
2292220Bp306Blood pressure QTL 3063.470.00087arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1164310393243914901Rat
1354615Cm32Cardiac mass QTL 325.2heart left ventricle mass (VT:0007031)heart left ventricle wet weight (CMO:0000071)1102813953201278233Rat
1600380Niddm70Non-insulin dependent diabetes mellitus QTL 703.10.0008blood insulin amount (VT:0001560)plasma insulin level (CMO:0000342)1176550523221550523Rat
1354610Bw34Body weight QTL 344.1body mass (VT:0001259)body weight (CMO:0000012)1151162512256448636Rat
1354620Kidm19Kidney mass QTL 194kidney mass (VT:0002707)calculated kidney weight (CMO:0000160)1151162512201278233Rat
1354618Kidm15Kidney mass QTL 155kidney mass (VT:0002707)left kidney wet weight (CMO:0000083)1156677124201278233Rat
6903303Scl34Serum cholesterol QTL 342.50.0033blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)1180359209218108781Rat
631549Bp89Blood pressure QTL 895.7arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1123350581201284552Rat
1358189Cstrr1Cold stress response QTL 10.0001catecholamine amount (VT:0010543)urine norepinephrine level (CMO:0001629)1123350408182418476Rat
2293083Iddm25Insulin dependent diabetes mellitus QTL 254.18blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)1181829673224569684Rat
1354606Bp246Blood pressure QTL 2463.6arterial blood pressure trait (VT:2000000)pulse pressure (CMO:0000292)1102813953218753816Rat
738032Hcas5Hepatocarcinoma susceptibility QTL 53.12liver integrity trait (VT:0010547)liver tumorous lesion number (CMO:0001068)1176426412257976495Rat
1354602Bw35Body weight QTL 3512.2body mass (VT:0001259)body weight (CMO:0000012)1151162512201278233Rat
2325725Eae31Experimental allergic encephalomyelitis QTL 31nervous system integrity trait (VT:0010566)experimental autoimmune encephalomyelitis severity score (CMO:0001419)1178810256188377506Rat
631670Iddm10Insulin dependent diabetes mellitus QTL 101.9blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)1174133260196383668Rat


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
nervous system
renal system
reproductive system
respiratory system
9 11 49 113 91 90 59 25 59 6 218 97 93 45 60 31

Sequence


Ensembl Acc Id: ENSRNOT00000026063   ⟹   ENSRNOP00000026063
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1182,415,546 - 182,434,325 (-)Ensembl
Rnor_6.0 Ensembl1199,251,844 - 199,270,627 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000109173   ⟹   ENSRNOP00000077893
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1182,415,546 - 182,441,280 (-)Ensembl
RefSeq Acc Id: NM_012700   ⟹   NP_036832
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81191,848,470 - 191,864,635 (-)NCBI
mRatBN7.21182,417,998 - 182,434,163 (-)NCBI
Rnor_6.01199,254,296 - 199,270,465 (-)NCBI
Rnor_5.01206,276,724 - 206,292,888 (-)NCBI
RGSC_v3.41187,092,014 - 187,108,481 (-)RGD
Celera1180,069,042 - 180,085,214 (-)RGD
Sequence:
RefSeq Acc Id: XM_063281069   ⟹   XP_063137139
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81191,846,016 - 191,864,878 (-)NCBI
Protein Sequences
Protein RefSeqs NP_036832 (Get FASTA)   NCBI Sequence Viewer  
  XP_063137139 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAA42197 (Get FASTA)   NCBI Sequence Viewer  
  EDM17230 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000026063.2
  ENSRNOP00000077893.1
  ENSRNOP00055042461
  ENSRNOP00060034664
  ENSRNOP00065019675
GenBank Protein P61265 (Get FASTA)   NCBI Sequence Viewer  
RefSeq Acc Id: NP_036832   ⟸   NM_012700
- UniProtKB: P61265 (UniProtKB/Swiss-Prot),   A6I9V0 (UniProtKB/TrEMBL),   A0A8I5Y9T5 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000026063   ⟸   ENSRNOT00000026063
Ensembl Acc Id: ENSRNOP00000077893   ⟸   ENSRNOT00000109173
RefSeq Acc Id: XP_063137139   ⟸   XM_063281069
- Peptide Label: isoform X1
Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P61265-F1-model_v2 AlphaFold P61265 1-288 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13690442
Promoter ID:EPDNEW_R967
Type:multiple initiation site
Name:Stx1b_1
Description:syntaxin 1B
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.01199,270,650 - 199,270,710EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:3784 AgrOrtholog
BIND 130903
  130913
  133976
  134472
  134477
  134479
BioCyc Gene G2FUF-57338 BioCyc
Ensembl Genes ENSRNOG00000019193 Ensembl, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ENSRNOG00055029735 UniProtKB/Swiss-Prot
  ENSRNOG00060024103 UniProtKB/Swiss-Prot
  ENSRNOG00065015178 UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000026063.5 UniProtKB/Swiss-Prot
  ENSRNOT00000109173.1 UniProtKB/TrEMBL
  ENSRNOT00055051517 UniProtKB/Swiss-Prot
  ENSRNOT00060041807 UniProtKB/Swiss-Prot
  ENSRNOT00065025135 UniProtKB/Swiss-Prot
Gene3D-CATH 1.20.5.110 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  1.20.5.520 UniProtKB/TrEMBL
  1.20.58.70 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro Beta-thymosin UniProtKB/TrEMBL
  Beta-thymosin_sf UniProtKB/TrEMBL
  SNARE UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Syntaxin UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Syntaxin/epimorphin_CS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Syntaxin_N UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  T_SNARE_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:24923 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
NCBI Gene 24923 ENTREZGENE
PANTHER PTHR19957 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PTHR19957:SF334 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam SNARE UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Syntaxin UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Thymosin UniProtKB/TrEMBL
PhenoGen Stx1b PhenoGen
PROSITE SYNTAXIN UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  T_SNARE UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
RatGTEx ENSRNOG00000019193 RatGTEx
  ENSRNOG00055029735 RatGTEx
  ENSRNOG00060024103 RatGTEx
  ENSRNOG00065015178 RatGTEx
SMART SynN UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  t_SNARE UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  THY UniProtKB/TrEMBL
Superfamily-SCOP SSF47661 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
TIGR TC232453
UniProt A0A8I5Y9T5 ENTREZGENE, UniProtKB/TrEMBL
  A6I9V0 ENTREZGENE, UniProtKB/TrEMBL
  P61265 ENTREZGENE, UniProtKB/Swiss-Prot
UniProt Secondary P32853 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2008-02-15 Stx1b  syntaxin 1B  Stx1b2  syntaxin 1B2  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2004-07-29 Stx1b2  syntaxin 1B2  Stx1b  syntaxin 1B  Data merged from RGD:67395 737654 APPROVED
2003-04-09 Stx1b2  syntaxin 1B2  Stx2  Syntaxin 2  Symbol and Name updated 629477 APPROVED
2002-06-10 Stx1b  syntaxin 1B      Symbol and Name status set to approved 70586 APPROVED
2002-06-10 Stx2  Syntaxin 2      Symbol and Name status set to approved 70586 APPROVED
2001-10-25 Stx1b  syntaxin 1B      Name updated 68916 RESERVED

RGD Curation Notes
Note Type Note Reference
gene_cellular_localization localize to the apical plasma membrane 1299065
gene_function binds to N-type Ca++ channels; forms a synaptic core complex with synaptosome associated proteins and synaptobrevin 1299065
gene_process involved in docking of synaptic vesicles at presynaptic active zones, in Ca++ dependent synaptic transmission, and in vesicular transport 1299065
gene_transcript mRNA upregulated in frontal cortex of AA rat strain compared to ANA rat strain 1358772