signal transducer and activator of transcription 5B
RGD ID:
3774
Description:
Enables several functions, including DNA binding activity; DNA-binding transcription factor activity; and chromatin binding activity. Involved in several processes, including cellular response to epidermal growth factor stimulus; receptor signaling pathway via JAK-STAT; and regulation of gene expression. Predicted to be located in cytoplasm and nucleus. Human ortholog(s) of this gene implicated in colon adenocarcinoma; colorectal adenocarcinoma; growth hormone insensitivity syndrome with immune dysregulation 1; and growth hormone insensitivity syndrome with immune dysregulation 2. Orthologous to human STAT5B (signal transducer and activator of transcription 5B); PARTICIPATES IN Jak-Stat signaling pathway; erythropoietin signaling pathway; fibroblast growth factor signaling pathway; INTERACTS WITH 1,2-dimethylhydrazine; 17beta-estradiol 3-benzoate; 2,3,7,8-tetrachlorodibenzodioxine.
(+)-JQ1 compound inhibits the reaction [[INS1 protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine] results in increased phosphorylation of STAT5B protein], [INS1 protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine] results in increased phosphorylation of STAT5B protein
[alpha-naphthoflavone binds to and results in decreased activity of AHR protein] inhibits the reaction [Hexachlorobenzene results in increased phosphorylation of and results in increased activity of STAT5B protein]
(+)-JQ1 compound inhibits the reaction [[INS1 protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine] results in increased phosphorylation of STAT5B protein], [INS1 protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine] results in increased phosphorylation of STAT5B protein
[AG 1879 results in decreased activity of SRC protein] inhibits the reaction [Hexachlorobenzene results in increased phosphorylation of STAT5B protein] more ...
[Phenanthrolines binds to and results in decreased activity of AHR protein] inhibits the reaction [Hexachlorobenzene results in increased phosphorylation of and results in increased activity of STAT5B protein]
[NOG protein co-treated with Phenylmercuric Acetate co-treated with dorsomorphin co-treated with 4-(5-benzo(1, 3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of STAT5B mRNA
(+)-JQ1 compound promotes the reaction [quizartinib results in decreased phosphorylation of STAT5B protein], quizartinib promotes the reaction [(+)-JQ1 compound results in decreased phosphorylation of STAT5B protein]
resveratrol promotes the reaction [sorafenib results in decreased phosphorylation of STAT5B protein], resveratrol results in decreased activity of and results in decreased phosphorylation of STAT5B protein
[NOG protein co-treated with trichostatin A co-treated with dorsomorphin co-treated with 4-(5-benzo(1, 3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of STAT5B mRNA
[RTKI cpd results in decreased activity of EGFR protein] inhibits the reaction [Hexachlorobenzene results in increased phosphorylation of and results in increased activity of STAT5B protein]
[NOG protein co-treated with Valproic Acid co-treated with dorsomorphin co-treated with 4-(5-benzo(1, 3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of STAT5B mRNA
[NOG protein co-treated with Vorinostat co-treated with dorsomorphin co-treated with 4-(5-benzo(1, 3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of STAT5B mRNA
Effects of chronic ethanol on hepatic and renal CYP2C11 in the male rat: interactions with the Janus-kinase 2-signal transducer and activators of transcription proteins 5b pathway.
ENDOTOXIN ATTENUATES GROWTH HORMONE INDUCED HEPATIC INSULIN-LIKE GROWTH FACTOR-1 EXPRESSION BY INHIBITING JAK2/STAT5 SIGNAL TRANSDUCTION AND STAT5b DNA BINDING.
Opposite nuclear level and binding activity of STAT5B and STAT3 proteins with rat haptoglobin gene under normal and turpentine induced acute phase conditions.
Activation of signal transducer and activator of transcription 5 is required for progression of autochthonous prostate cancer: evidence from the transgenic adenocarcinoma of the mouse prostate system.
Signal transducers and activators of transcription 5b activation enhances hepatocellular carcinoma aggressiveness through induction of epithelial-mesenchymal transition.
Nuclear localization and binding affinity of STAT5b for the alpha(2)-macroglobulin gene promoter during rat liver development and the acute-phase response.
Inhibitory cross-talk between STAT5b and liver nuclear factor HNF3beta: impact on the regulation of growth hormone pulse-stimulated, male-specific liver cytochrome P-450 gene expression.
Modulation of signal transducers and activators of transcription (STAT) factor pathways during focal cerebral ischaemia: a gene expression array study in rat hippocampus after middle cerebral artery occlusion.
Gene-based anchoring of the rat genetic linkage and cytogenetic maps: new regional localizations, orientation of the linkage groups, and insights into mammalian chromosome evolution.
HNF3beta inhibits Stat5b activation at the level of Stat5b tyrosine phosphorylation; Stat5b inhibits HNF3beta by an unknown mechanism; neither inhibition is dependent on DNA binding
exposure of H4 hepatoma cells to growth hormone (GH) results in a reversible time-, concentration- and growth hormone receptor concentration-dependent increase in tyrosine phosphorylation of STAT5
