Sstr4 (somatostatin receptor 4) - Rat Genome Database

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Gene: Sstr4 (somatostatin receptor 4) Rattus norvegicus
Analyze
Symbol: Sstr4
Name: somatostatin receptor 4
RGD ID: 3764
Description: Enables somatostatin receptor activity. Involved in several processes, including cellular response to glucocorticoid stimulus; positive regulation of arachidonate secretion; and regulation of signal transduction. Predicted to be active in neuron projection and plasma membrane. Biomarker of status epilepticus. Orthologous to human SSTR4 (somatostatin receptor 4); PARTICIPATES IN cimetidine pharmacodynamics pathway; esomeprazole pharmacodynamics pathway; famotidine pharmacodynamics pathway; INTERACTS WITH (+)-pilocarpine; 6-propyl-2-thiouracil; acrylamide.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: Smstr4; Somatostatin receptor subtype 4 Rattus norvegicus Sprague-Dawley major hippocampal somatostatin receptor (SSTR4) mRNA; somatostatin receptor type 4; SS-4-R; SS4-R; SS4R
RGD Orthologs
Human
Mouse
Bonobo
Squirrel
Green Monkey
Alliance Orthologs
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr83156,307,992 - 156,309,855 (+)NCBIGRCr8
mRatBN7.23135,854,826 - 135,856,689 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl3135,854,826 - 135,856,689 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx3139,797,830 - 139,799,693 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.03148,381,963 - 148,383,826 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.03146,080,466 - 146,082,329 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.03142,739,781 - 142,741,644 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl3142,739,781 - 142,741,644 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.03149,151,003 - 149,152,866 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.43137,150,419 - 137,152,284 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.13137,055,991 - 137,057,857 (+)NCBI
Celera3134,698,650 - 134,700,513 (+)NCBICelera
Cytogenetic Map3q41NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Functional coupling of SSTR4, a major hippocampal somatostatin receptor, to adenylate cyclase inhibition, arachidonate release and activation of the mitogen-activated protein kinase cascade. Bito H, etal., J Biol Chem. 1994 Apr 29;269(17):12722-30.
2. Identification of multiple somatostatin receptors in the rat somatosensory cortex during development. Bologna E and Leroux P, J Comp Neurol. 2000 May 15;420(4):466-80.
3. Expression changes of somatostatin receptor subtypes sst2A, sst2B, sst3 and sst4 after a cortical contusion trauma in rats. Braun H, etal., Brain Res. 2002 Mar 15;930(1-2):191-9.
4. Molecular cloning and functional expression of a brain-specific somatostatin receptor. Bruno JF, etal., Proc Natl Acad Sci U S A 1992 Dec 1;89(23):11151-5.
5. Interaction of brain somatostatin receptors with the PDZ domains of PSD-95. Christenn M, etal., FEBS Lett. 2007 Nov 13;581(27):5173-7. Epub 2007 Oct 12.
6. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
7. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
8. A potential role of somatostatin and its receptor SSTR4 in the migration of hepatic oval cells. Jung Y, etal., Lab Invest. 2006 May;86(5):477-89.
9. Identification of somatostatin receptor subtypes and an implication for the efficacy of somatostatin analogue SMS 201-995 in treatment of human endocrine tumors. Kubota A, etal., J Clin Invest. 1994 Mar;93(3):1321-5.
10. Expression of the five somatostatin receptor (SSTR1-5) subtypes in rat pituitary somatotrophes: quantitative analysis by double-layer immunofluorescence confocal microscopy. Kumar U, etal., Endocrinology. 1997 Oct;138(10):4473-6.
11. The expression of somatostatin receptors in the hippocampus of pilocarpine-induced rat epilepsy model. Kwak SE, etal., Neuropeptides. 2008 Oct-Dec;42(5-6):569-83. Epub 2008 Oct 31.
12. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
13. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
14. Molecular cloning and expression of a pituitary somatostatin receptor with preferential affinity for somatostatin-28. O'Carroll AM, etal., Mol Pharmacol 1992 Dec;42(6):939-46.
15. Role of glucocorticoids in the regulation of pituitary somatostatin receptor subtype (sst1-sst5) mRNA levels: evidence for direct and somatostatin-mediated effects. Park S, etal., Neuroendocrinology. 2003 Sep;78(3):163-75.
16. SMPDB Annotation Import Pipeline Pipeline to import SMPDB annotations from SMPDB into RGD
17. GOA pipeline RGD automated data pipeline
18. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
19. Tentative Sequence Identification Numbers Tentative Sequence Data IDs. TIGR Gene Index, Rat Data
20. Vasculoprotective effects of somatostatin receptor subtypes. Tigerstedt NM, etal., Mol Cell Endocrinol. 2007 Dec 15;279(1-2):34-8. Epub 2007 Sep 11.
21. Ligand Binding and Functional Properties of the Rat Somatostatin Receptor SSTR4 Stably Expressed in Chinese Hamster Ovary Cells. Xu Y, etal., Mol Cell Neurosci. 1993 Jun;4(3):245-9.
Additional References at PubMed
PMID:17617126   PMID:20573967   PMID:22098068   PMID:23233668   PMID:24416361   PMID:24769416   PMID:25926390   PMID:30291955  


Genomics

Comparative Map Data
Sstr4
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr83156,307,992 - 156,309,855 (+)NCBIGRCr8
mRatBN7.23135,854,826 - 135,856,689 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl3135,854,826 - 135,856,689 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx3139,797,830 - 139,799,693 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.03148,381,963 - 148,383,826 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.03146,080,466 - 146,082,329 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.03142,739,781 - 142,741,644 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl3142,739,781 - 142,741,644 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.03149,151,003 - 149,152,866 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.43137,150,419 - 137,152,284 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.13137,055,991 - 137,057,857 (+)NCBI
Celera3134,698,650 - 134,700,513 (+)NCBICelera
Cytogenetic Map3q41NCBI
SSTR4
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh382023,035,312 - 23,039,237 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl2023,035,312 - 23,039,237 (+)EnsemblGRCh38hg38GRCh38
GRCh372023,015,949 - 23,019,874 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 362022,964,057 - 22,965,314 (+)NCBINCBI36Build 36hg18NCBI36
Build 342022,964,120 - 22,965,287NCBI
Celera2023,089,437 - 23,090,694 (+)NCBICelera
Cytogenetic Map20p11.21NCBI
HuRef2022,977,578 - 22,978,835 (+)NCBIHuRef
CHM1_12023,016,757 - 23,018,014 (+)NCBICHM1_1
T2T-CHM13v2.02023,094,793 - 23,098,718 (+)NCBIT2T-CHM13v2.0
Sstr4
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm392148,237,297 - 148,238,684 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl2148,237,264 - 148,238,687 (+)EnsemblGRCm39 Ensembl
GRCm382148,395,377 - 148,396,764 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl2148,395,344 - 148,396,767 (+)EnsemblGRCm38mm10GRCm38
MGSCv372148,221,113 - 148,222,500 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv362148,086,783 - 148,092,384 (+)NCBIMGSCv36mm8
Celera2149,668,860 - 149,670,247 (+)NCBICelera
Cytogenetic Map2G3NCBI
cM Map273.44NCBI
SSTR4
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v22123,913,464 - 23,917,519 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan12023,910,298 - 23,914,353 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v02022,982,009 - 22,986,058 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.12023,333,445 - 23,334,933 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl2023,333,320 - 23,334,766 (+)Ensemblpanpan1.1panPan2
Sstr4
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024408640149,149,383 - 149,157,532 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049366202,576,598 - 2,577,761 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049366202,575,880 - 2,577,761 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
SSTR4
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1252,027,241 - 52,034,777 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl252,031,021 - 52,032,187 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_0236660786,842,484 - 6,846,721 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0

Variants

.
Variants in Sstr4
7 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:86
Count of miRNA genes:72
Interacting mature miRNAs:85
Transcripts:ENSRNOT00000006181
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
2312673Scl63Serum cholesterol level QTL 630.001blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)398535255168026850Rat
1578653Vnigr3Vascular neointimal growth QTL 33.1artery morphology trait (VT:0002191)artery neointimal hyperplastic lesion area (CMO:0001414)3130656562169034231Rat
1598877Bp285Blood pressure QTL 2851.50.03arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)3120538241165538241Rat
2302373Gluco39Glucose level QTL 395.01blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)398535386161695835Rat
70216Cm14Cardiac mass QTL 142.1heart mass (VT:0007028)heart wet weight (CMO:0000069)331172320163586636Rat
2292591Esta4Estrogen-induced thymic atrophy QTL 4thymus mass (VT:0004954)thymus wet weight (CMO:0000855)347233211147415807Rat
1581568Rf53Renal function QTL 53urine total protein amount (VT:0000032)urine protein excretion rate to body weight ratio (CMO:0001099)356395968161299569Rat
1578754Stresp16Stress response QTL 1640.001blood renin amount (VT:0003349)plasma renin activity level (CMO:0000116)3112681431157681431Rat
1300173Rf11Renal function QTL 113.38renal blood flow trait (VT:2000006)absolute change in renal blood flow rate (CMO:0001168)3121056165145956249Rat
9589106Insul23Insulin level QTL 2313.860.001blood insulin amount (VT:0001560)plasma insulin level (CMO:0000342)3131635904169034231Rat
8694437Bw167Body weight QTL 16722.460.001retroperitoneal fat pad mass (VT:0010430)retroperitoneal fat pad weight to body weight ratio (CMO:0000635)391797474136797474Rat
10755461Coatc16Coat color QTL 16coat/hair pigmentation trait (VT:0010463)pigmented ventral coat/hair area to total ventral coat/hair area ratio (CMO:0001812)3122438700167438700Rat
8662816Vetf4Vascular elastic tissue fragility QTL 44renal artery integrity trait (VT:0010642)number of ruptures of the internal elastic lamina of the renal arteries (CMO:0002563)359242096157323038Rat
1559282Emca5Estrogen-induced mammary cancer QTL 53.9mammary gland integrity trait (VT:0010552)percentage of study population developing mammary tumors during a period of time (CMO:0000948)343827364169034231Rat
1354611Despr2Despair related QTL 23.030.0028locomotor behavior trait (VT:0001392)amount of time spent in voluntary immobility (CMO:0001043)397084464142084464Rat
2303620Vencon4Ventilatory control QTL 43.9respiration trait (VT:0001943)tidal volume (CMO:0000222)3127162703168026850Rat
631841Niddm39Non-insulin dependent diabetes mellitus QTL 393.36blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)394856903159898684Rat
1576306Schws3Schwannoma susceptibility QTL 30.001nervous system integrity trait (VT:0010566)percentage of study population developing trigeminal nerve neurilemmomas during a period of time (CMO:0002017)3118839124163839124Rat
619618Rf3Renal disease susceptibility QTL 36.50.001urine albumin amount (VT:0002871)urine albumin excretion rate to body weight ratio (CMO:0001270)3107693393152693393Rat
1300159Kidm4Kidney mass QTL 43.83kidney mass (VT:0002707)right kidney wet weight to body weight ratio (CMO:0001953)3121056165157309487Rat
631673Iddm13Insulin dependent diabetes mellitus QTL 131.30.663blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)3130193298161695983Rat
2312659Slep7Serum leptin concentration QTL 70.001blood leptin amount (VT:0005667)serum leptin level (CMO:0000780)398535255168026850Rat
2301971Cm71Cardiac mass QTL 714.63heart left ventricle mass (VT:0007031)heart left ventricle weight (CMO:0000776)341874578155617519Rat
2301970Bw81Body weight QTL 815.19body mass (VT:0001259)body weight (CMO:0000012)341874578155617519Rat
1581546Pur13Proteinuria QTL 132.930.0335urine total protein amount (VT:0000032)urine protein excretion rate (CMO:0000759)378196190146592722Rat
1578656Vnigr2Vascular neointimal growth QTL 24.2artery morphology trait (VT:0002191)lesioned artery residual lumen area (CMO:0001417)3130656562169034231Rat
631541Bp81Blood pressure QTL 814arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)3124122556169034231Rat
2312670Bw94Body weight QTL 940.01inguinal fat pad mass (VT:0010424)inguinal fat pad weight to body weight ratio (CMO:0001253)398535255168026850Rat
2293087Iddm27Insulin dependent diabetes mellitus QTL 272.68blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)397551417147415807Rat
724532Cm17Cardiac mass QTL 172heart mass (VT:0007028)calculated heart weight (CMO:0000073)395735366140735366Rat


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
nervous system
renal system
reproductive system
respiratory system
9 7 49 113 62 61 32 23 32 6 181 92 93 41 54 29

Sequence


Ensembl Acc Id: ENSRNOT00000006181   ⟹   ENSRNOP00000066231
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl3135,854,826 - 135,856,689 (+)Ensembl
Rnor_6.0 Ensembl3142,739,781 - 142,741,644 (+)Ensembl
RefSeq Acc Id: NM_013036   ⟹   NP_037168
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr83156,307,992 - 156,309,855 (+)NCBI
mRatBN7.23135,854,826 - 135,856,689 (+)NCBI
Rnor_6.03142,739,781 - 142,741,644 (+)NCBI
Rnor_5.03149,151,003 - 149,152,866 (+)NCBI
RGSC_v3.43137,150,419 - 137,152,284 (+)RGD
Celera3134,698,650 - 134,700,513 (+)RGD
Sequence:
Protein Sequences
Protein RefSeqs NP_037168 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAA17519 (Get FASTA)   NCBI Sequence Viewer  
  AAA42180 (Get FASTA)   NCBI Sequence Viewer  
  EDL95103 (Get FASTA)   NCBI Sequence Viewer  
  EDL95104 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000066231.1
  ENSRNOP00055036173
  ENSRNOP00060002266
  ENSRNOP00065035894
GenBank Protein P30937 (Get FASTA)   NCBI Sequence Viewer  
RefSeq Acc Id: NP_037168   ⟸   NM_013036
- UniProtKB: P30937 (UniProtKB/Swiss-Prot),   A6K7B6 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000066231   ⟸   ENSRNOT00000006181
Protein Domains
G-protein coupled receptors family 1 profile

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P30937-F1-model_v2 AlphaFold P30937 1-384 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:3764 AgrOrtholog
BioCyc Gene G2FUF-47510 BioCyc
Ensembl Genes ENSRNOG00000004641 Ensembl, UniProtKB/Swiss-Prot
  ENSRNOG00055025636 UniProtKB/Swiss-Prot
  ENSRNOG00060002122 UniProtKB/Swiss-Prot
  ENSRNOG00065025398 UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000006181.7 UniProtKB/Swiss-Prot
  ENSRNOT00055044215 UniProtKB/Swiss-Prot
  ENSRNOT00060003310 UniProtKB/Swiss-Prot
  ENSRNOT00065043745 UniProtKB/Swiss-Prot
Gene3D-CATH Rhodopsin 7-helix transmembrane proteins UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro GPCR_Rhodpsn UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  GPCR_Rhodpsn_7TM UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Somatstn_rcpt UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Somatstn_rcpt_4 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:25555 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
NCBI Gene 25555 ENTREZGENE
PANTHER NEUROPEPTIDES RECEPTOR UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SOMATOSTATIN RECEPTOR TYPE 4 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam 7tm_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Sstr4 PhenoGen
PRINTS GPCRRHODOPSN UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SOMATOSTATNR UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SOMATOSTTN4R UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE G_PROTEIN_RECEP_F1_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  G_PROTEIN_RECEP_F1_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
RatGTEx ENSRNOG00000004641 RatGTEx
  ENSRNOG00055025636 RatGTEx
  ENSRNOG00060002122 RatGTEx
  ENSRNOG00065025398 RatGTEx
SMART 7TM_GPCR_Srsx UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP Family A G protein-coupled receptor-like UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
TIGR TC211734
UniProt A6K7B6 ENTREZGENE, UniProtKB/TrEMBL
  P30937 ENTREZGENE, UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2003-04-09 Sstr4  somatostatin receptor 4    Somatostatin receptor subtype 4 Rattus norvegicus Sprague-Dawley major hippocampal somatostatin receptor (SSTR4) mRNA  Symbol and Name updated 629477 APPROVED
2002-06-10 Sstr4  Somatostatin receptor subtype 4 Rattus norvegicus Sprague-Dawley major hippocampal somatostatin receptor (SSTR4) mRNA      Symbol and Name status set to approved 70586 APPROVED

RGD Curation Notes
Note Type Note Reference
gene_expression mRNA expressed in various brain regions, particularly in cortex and hippocampus 727543
gene_physical_interaction higher affinity for somatostatin 14 than for somatostatin 28 727543
gene_product member of the seven transmembrane domain superfamily of G-protein coupled receptors 727543
gene_protein predicted protein contains 384 aa residues 727543