Spp1 (secreted phosphoprotein 1) - Rat Genome Database

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Gene: Spp1 (secreted phosphoprotein 1) Rattus norvegicus
Symbol: Spp1
Name: secreted phosphoprotein 1
RGD ID: 3752
Description: Predicted to enable extracellular matrix binding activity; integrin binding activity; and ion binding activity. Involved in several processes, including negative regulation of collateral sprouting of intact axon in response to injury; positive regulation of bone resorption; and response to macrophage colony-stimulating factor. Located in several cellular components, including extracellular space; perinuclear region of cytoplasm; and vesicle. Used to study several diseases, including encephalomyelitis; myocarditis; radiculopathy; renovascular hypertension; and visual epilepsy. Biomarker of autosomal dominant polycystic kidney disease; calcinosis; and glomerulosclerosis. Human ortholog(s) of this gene implicated in several diseases, including autoimmune disease (multiple); biliary atresia; coronary artery disease (multiple); disease of cellular proliferation (multiple); and hepatitis. Orthologous to human SPP1 (secreted phosphoprotein 1); PARTICIPATES IN diabetic nephropathy pathway; c-Jun N-terminal kinases MAPK signaling pathway; fibroblast growth factor signaling pathway; INTERACTS WITH (R,R)-tramadol; (S)-naringenin; 1,3,5-trinitro-1,3,5-triazinane.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: bone sialoprotein 1; LOC100359743; OSP; osteopontin; osteopontin-like; Sialoprotein (osteopontin); SPP-1
RGD Orthologs
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Allele / Splice: Spp1em1Mcwi   spp1em3Mcwi   Spp1em4Mcwi   Spp1em2Mcwi  
Genetic Models: SS-Spp1em3Mcwi SHRSP-Spp1em2Mcwi SHRSP-Spp1em1Mcwi SS-Spp1em4Mcwi
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Rat AssemblyChrPosition (strand)SourceGenome Browsers
GRCr8145,613,569 - 5,620,695 (-)NCBIGRCr8
mRatBN7.2145,308,885 - 5,315,120 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl145,308,885 - 5,315,162 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx145,269,750 - 5,275,787 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0146,569,945 - 6,575,982 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0145,261,625 - 5,267,707 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0146,673,686 - 6,679,965 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl146,673,686 - 6,679,901 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0146,653,086 - 6,658,937 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.1146,422,741 - 6,426,400 (-)NCBI
Celera145,447,814 - 5,453,553 (-)NCBICelera
RH 3.4 Map1484.5RGD
Cytogenetic Map14p22NCBI
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations     Click to see Annotation Detail View
acute kidney failure  (ISO)
adenocarcinoma  (ISO)
Albuminuria  (IEP)
Alcoholic Liver Diseases  (ISO)
allergic contact dermatitis  (ISO)
allergic disease  (ISO)
Aneurysm  (ISO)
Angina Pectoris  (ISO)
anti-basement membrane glomerulonephritis  (ISO)
aortic aneurysm  (ISO)
aortic dissection  (ISO)
asbestosis  (ISO)
autosomal dominant polycystic kidney disease  (IEP,ISO)
biliary atresia  (ISO)
Brain Neoplasms  (ISO)
Breast Neoplasms  (ISO)
calcinosis  (IEP,ISO)
Cardiomegaly  (ISO)
carotid stenosis  (ISO)
Cerebral Hemorrhage  (ISO)
Chemical and Drug Induced Liver Injury  (ISO)
Chronic Hepatitis C  (ISO)
coronary artery disease  (ISO)
coronary restenosis  (ISO)
Cystic, Mucinous, and Serous Neoplasms  (ISO)
Diabetic Cardiomyopathies  (ISO)
Diabetic Nephropathies  (IDA)
disease of cellular proliferation  (ISO)
Drug-Related Side Effects and Adverse Reactions  (ISO)
encephalomyelitis  (IDA)
Endometrioid Carcinomas  (ISO)
Experimental Autoimmune Neuritis  (IDA)
Experimental Diabetes Mellitus  (IDA)
Experimental Liver Cirrhosis  (IDA)
Experimental Liver Neoplasms  (ISO)
Experimental Mammary Neoplasms  (ISO)
Experimental Neoplasms  (ISO)
Fibrosis  (ISO)
focal segmental glomerulosclerosis  (ISO)
Foreign-Body Reaction  (ISO)
genetic disease  (ISO)
glomerulonephritis  (IMP)
glomerulosclerosis  (IEP)
heart disease  (ISO)
heart valve disease  (ISO)
hepatitis  (ISO)
hepatocellular carcinoma  (ISO)
high grade glioma  (IDA,ISO)
Inflammation  (ISO)
Kidney Calculi  (IEP,ISO)
kidney disease  (ISO)
kidney failure  (ISO)
Laryngeal Neoplasms  (ISO)
Leukoencephalopathies  (ISO)
liver cirrhosis  (ISO)
Lung Neoplasms  (ISO)
lung non-small cell carcinoma  (ISO)
malaria  (ISO)
melanoma  (ISO)
Mesothelioma  (ISO)
multiple myeloma  (ISO)
multiple sclerosis  (ISO)
myocardial infarction  (ISO)
Myocardial Reperfusion Injury  (ISO)
myocarditis  (IDA)
Neoplasm Metastasis  (ISO)
Neovascularization, Pathologic  (ISO)
Nervous System Trauma  (IDA)
Osteolysis  (ISO)
Ovarian Neoplasms  (ISO)
pancreas disease  (ISO)
pancreatic cancer  (ISO)
Pleural Neoplasms  (ISO)
pneumonia  (ISO)
progressive osseous heteroplasia  (ISO)
prostate carcinoma  (ISO)
Prostatic Neoplasms  (ISO)
proteinuria  (ISO)
pulmonary fibrosis  (ISO)
radiculopathy  (IDA)
renovascular hypertension  (IDA)
Reperfusion Injury  (ISO)
rheumatoid arthritis  (ISO)
scrapie  (ISO)
Spinal Cord Injuries  (ISO)
Stomach Neoplasms  (ISO)
Thyroid Neoplasms  (ISO)
tuberculosis  (ISO)
uremia  (ISO)
urinary bladder cancer  (ISO)
Urinary Calculi  (ISO)
Vascular System Injuries  (ISO)
visual epilepsy  (IDA)
Wounds and Injuries  (ISO)

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(R,R)-tramadol  (EXP)
(S)-naringenin  (EXP)
(S)-nicotine  (ISO)
1,2-dimethylhydrazine  (ISO)
1,3,5-trinitro-1,3,5-triazinane  (EXP)
1,4-dichlorobenzene  (ISO)
1-chloro-2,4-dinitrobenzene  (EXP)
1-fluoro-2,4-dinitrobenzene  (ISO)
1-methylphenanthrene  (ISO)
1-naphthyl isothiocyanate  (EXP,ISO)
1-nitropyrene  (ISO)
11-deoxycorticosterone  (EXP)
15-deoxy-Delta(12,14)-prostaglandin J2  (ISO)
17alpha-ethynylestradiol  (EXP,ISO)
17beta-estradiol  (EXP,ISO)
17beta-estradiol 3-benzoate  (EXP)
17beta-hydroxy-5alpha-androstan-3-one  (ISO)
1H-[1,2,4]oxadiazolo[4,3-a]quinoxalin-1-one  (ISO)
2,2',4,4',5,5'-hexachlorobiphenyl  (EXP,ISO)
2,2',4,4'-Tetrabromodiphenyl ether  (EXP,ISO)
2,2',5,5'-tetrachlorobiphenyl  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,3-dimethoxynaphthalene-1,4-dione  (ISO)
2,4,6-trinitrobenzenesulfonic acid  (ISO)
2,4-D  (ISO)
2,4-di-tert-butylphenol  (ISO)
2,4-dibromophenyl 2,4,5-tribromophenyl ether  (ISO)
2,6-di-tert-butyl-4-methylphenol  (ISO)
2-amino-2-deoxy-D-galactopyranose  (ISO)
2-Hydroxy-6-(8,11,14-pentadecatrienyl)benzoic acid  (ISO)
2-palmitoylglycerol  (ISO)
3'-amino-3'-deoxy-N(6),N(6)-dimethyladenosine  (EXP)
3,3',4,4',5-pentachlorobiphenyl  (EXP,ISO)
3,3',5,5'-tetrabromobisphenol A  (ISO)
3-aminobenzamide  (ISO)
3-chloropropane-1,2-diol  (ISO)
3-isobutyl-1-methyl-7H-xanthine  (EXP)
4,4'-diaminodiphenylmethane  (EXP)
4,4'-sulfonyldiphenol  (ISO)
4-aminophenol  (EXP)
5-aza-2'-deoxycytidine  (ISO)
6-propyl-2-thiouracil  (EXP)
7,12-dimethyltetraphene  (EXP,ISO)
8-Br-cAMP  (EXP,ISO)
8-bromo-3',5'-cyclic GMP  (EXP)
9-cis-retinoic acid  (ISO)
acetaldehyde  (ISO)
acetylsalicylic acid  (EXP)
acrylic acid  (EXP)
adefovir  (EXP)
adenine  (EXP)
aflatoxin B1  (EXP,ISO)
agomelatine  (EXP)
aldehydo-D-glucose  (EXP,ISO)
all-trans-retinoic acid  (EXP,ISO)
allyl alcohol  (EXP)
Allylamine  (EXP)
aluminium atom  (ISO)
aluminium oxide  (ISO)
aluminium(0)  (ISO)
aminoglutethimide  (EXP)
ammonium chloride  (EXP)
amphotericin B  (EXP)
amphotericin B methyl ester  (ISO)
andrographolide  (ISO)
angiotensin II  (ISO)
aniline  (ISO)
anthra[1,9-cd]pyrazol-6(2H)-one  (EXP,ISO)
anthracen-2-amine  (EXP)
aristolochic acid A  (EXP,ISO)
Aroclor 1254  (ISO)
arsenite(3-)  (ISO)
arsenous acid  (ISO)
asbestos  (ISO)
asperentin  (ISO)
astaxanthin  (ISO)
aucubin  (ISO)
bacitracin  (EXP)
benazepril  (EXP)
benzo[a]pyrene  (EXP,ISO)
benzo[b]fluoranthene  (EXP,ISO)
berberine  (ISO)
beta-naphthoflavone  (ISO)
bexarotene  (EXP)
bezafibrate  (ISO)
bis(2-chloroethyl) sulfide  (ISO)
bis(2-ethylhexyl) phthalate  (ISO)
bisphenol A  (EXP,ISO)
bisphenol F  (ISO)
bleomycin A2  (ISO)
bortezomib  (ISO)
budesonide  (ISO)
Butylparaben  (ISO)
butyric acid  (EXP,ISO)
C60 fullerene  (EXP)
cadmium atom  (EXP,ISO)
cadmium dichloride  (EXP,ISO)
caffeine  (EXP,ISO)
calciol  (ISO)
calcitriol  (EXP,ISO)
calcium atom  (EXP,ISO)
calcium carbonate  (ISO)
calcium oxalate  (EXP)
calcium(0)  (EXP,ISO)
cannabidiol  (ISO)
capsaicin  (EXP)
carbamazepine  (ISO)
carbofuran  (EXP)
carbon nanotube  (EXP,ISO)
celecoxib  (EXP)
ceric oxide  (EXP)
CGP 52608  (ISO)
chitosan  (ISO)
chloroprene  (ISO)
chlorpromazine  (ISO)
chlorpyrifos  (ISO)
choline  (ISO)
chrysene  (ISO)
cisplatin  (EXP,ISO)
Clofop  (ISO)
clozapine  (ISO)
cobalt atom  (ISO)
cobalt dichloride  (EXP,ISO)
copper atom  (EXP,ISO)
copper(0)  (EXP,ISO)
copper(II) sulfate  (ISO)
corticosterone  (EXP)
crocidolite asbestos  (ISO)
Cuprizon  (EXP)
curcumin  (EXP)
cyanuric acid  (EXP)
cyclophosphamide  (EXP,ISO)
cyclosporin A  (EXP,ISO)
cypermethrin  (ISO)
D-glucose  (EXP,ISO)
decabromodiphenyl ether  (EXP)
deoxynivalenol  (ISO)
dexamethasone  (ISO)
dextran sulfate  (ISO)
diallyl trisulfide  (ISO)
diamminedichloroplatinum  (ISO)
diarsenic trioxide  (ISO)
dibenz[a,h]anthracene  (EXP,ISO)
dibenzo[a,l]pyrene  (EXP)
dibutyl phthalate  (EXP)
diethylstilbestrol  (EXP,ISO)
dioxygen  (EXP,ISO)
dipyridamole  (EXP)
disodium selenite  (ISO)
diuron  (ISO)
divanadium pentaoxide  (EXP)
dorsomorphin  (ISO)
doxorubicin  (EXP,ISO)
elemental selenium  (ISO)
enalapril  (EXP,ISO)
endosulfan  (EXP)
entinostat  (ISO)
Erionite  (ISO)
ethanol  (EXP,ISO)
ethylene glycol  (EXP)
etoposide  (ISO)
Falecalcitriol  (ISO)
fisetin  (EXP)
flavonoids  (EXP)
flunisolide  (ISO)
fluoranthene  (ISO)
fluvastatin  (EXP)
folic acid  (ISO)
FR900359  (ISO)
fructose  (ISO)
fulvestrant  (EXP,ISO)
furan  (EXP)
gadodiamide hydrate  (EXP)
gadolinium atom  (ISO)
gadolinium trichloride  (ISO)
gallocatechin  (EXP)
gemcitabine  (ISO)
genistein  (EXP,ISO)
gentamycin  (EXP)
Ginkgoic acid  (ISO)
glucose  (EXP,ISO)
glycerol 1-phosphate  (ISO)
glycerol 2-phosphate  (ISO)
glycidol  (ISO)
glyoxylic acid  (EXP)
graphite  (EXP,ISO)
griseofulvin  (ISO)
Hexachloro-1,3-butadiene  (EXP)
hydrogen peroxide  (EXP,ISO)
icariin  (EXP,ISO)
imperatorin  (EXP)
indole-3-methanol  (EXP)
inulin  (ISO)
iron(2+) sulfate (anhydrous)  (ISO)
isocyanuric acid  (EXP)
isoniazide  (EXP,ISO)
isonicotinamide  (ISO)
isoprenaline  (EXP,ISO)
isotretinoin  (ISO)
ivermectin  (ISO)
jaspamide  (ISO)
kaempferol  (ISO)
ketoconazole  (EXP)
kojic acid  (ISO)
KT 5823  (EXP)
L-ascorbic acid  (ISO)
L-ascorbic acid 2-phosphate  (ISO)
L-methionine  (ISO)
lead diacetate  (ISO)
lead(0)  (ISO)
lidocaine  (EXP)
linalool  (EXP)
lipopolysaccharide  (ISO)
losartan  (EXP)
LY 364947  (ISO)
LY294002  (EXP)
magnesium atom  (ISO)
maneb  (ISO)
medroxyprogesterone acetate  (ISO)
melamine  (EXP)
melatonin  (ISO)
mercury atom  (ISO)
mercury dibromide  (ISO)
mercury dichloride  (EXP,ISO)
mercury(0)  (ISO)
mesalamine  (EXP)
metaproterenol  (EXP)
methapyrilene  (EXP)
methotrexate  (EXP)
methylmercury chloride  (EXP,ISO)
methylparaben  (ISO)
microcystin-LR  (ISO)
milrinone  (EXP)
mitoxantrone  (EXP)
mometasone furoate  (ISO)
Morroniside  (EXP,ISO)
Muraglitazar  (EXP)
mycophenolic acid  (ISO)
mycotoxin  (ISO)
myo-inositol hexakisphosphate  (ISO)
N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine  (ISO)
N-[2-(4-bromocinnamylamino)ethyl]isoquinoline-5-sulfonamide  (EXP)
N-acetyl-L-cysteine  (EXP)
N-ethyl-N-nitrosourea  (EXP)
N-methyl-N'-nitro-N-nitrosoguanidine  (ISO)
N-methyl-N-nitrosourea  (EXP)
N-nitrosodiethylamine  (EXP)
N-nitrosodimethylamine  (ISO)
naproxen  (EXP)
naringin  (EXP,ISO)
natamycin  (ISO)
neoechinulin A  (ISO)
nickel atom  (ISO)
nickel dichloride  (ISO)
nickel sulfate  (ISO)
nicotine  (ISO)
nifedipine  (ISO)
nitric oxide  (ISO)
nitroprusside  (ISO)
nystatin  (ISO)
O-methyleugenol  (ISO)
ochratoxin A  (EXP,ISO)
okadaic acid  (ISO)
orciprenaline  (EXP)
oxalic acid  (ISO)
oxaliplatin  (EXP)
oxidopamine  (EXP)
ozone  (EXP,ISO)
p-chloromercuribenzoic acid  (ISO)
panobinostat  (ISO)
paracetamol  (ISO)
paraquat  (EXP,ISO)
paricalcitol  (ISO)
PD 0325901  (ISO)
PD123319  (EXP)
pentane-2,3-dione  (EXP)
Pentoxifylline  (EXP)
perfluorobutyric acid  (ISO)
perfluorooctane-1-sulfonic acid  (EXP,ISO)
perfluorooctanoic acid  (ISO)
phenobarbital  (ISO)
phenylephrine  (EXP)
phenylmercury acetate  (ISO)
phorbol 13-acetate 12-myristate  (ISO)
phosphonoformic acid  (ISO)
phosphorus atom  (ISO)
phosphorus(.)  (ISO)
phylloquinone  (ISO)
pioglitazone  (EXP)
pirfenidone  (EXP)
pirinixic acid  (ISO)
piroxicam  (ISO)
potassium bromate  (EXP,ISO)
progesterone  (ISO)
protein kinase inhibitor  (ISO)
Ptaquiloside  (ISO)
pyrrolidine dithiocarbamate  (EXP)
quartz  (EXP)
quercetin  (EXP,ISO)
raloxifene  (ISO)
resveratrol  (EXP,ISO)
rolipram  (EXP)
rotenone  (EXP,ISO)
S-butyl-DL-homocysteine (S,R)-sulfoximine  (ISO)
Salidroside  (ISO)
Salinomycin  (ISO)
SB 203580  (EXP)
SB 431542  (ISO)
sclareol  (ISO)
Se-methyl-L-selenocysteine  (ISO)
Se-methylselenocysteine  (ISO)
selenium atom  (ISO)
serpentine asbestos  (ISO)
silicon dioxide  (EXP,ISO)
silver atom  (ISO)
silver(0)  (ISO)
simvastatin  (EXP,ISO)
sirolimus  (ISO)
sodium arsenite  (ISO)
sodium chloride  (EXP)
sodium dichromate  (EXP)
sodium fluoride  (EXP,ISO)
sterigmatocystin  (ISO)
streptozocin  (EXP)
strontium atom  (ISO)
succimer  (ISO)
sulfaphenazole  (ISO)
sulfasalazine  (ISO)
sulforaphane  (ISO)
sumatriptan  (EXP)
tacrolimus hydrate  (EXP)
tamibarotene  (ISO)
tamoxifen  (ISO)
Tanshinone I  (EXP)
telmisartan  (EXP)
temozolomide  (ISO)
Tesaglitazar  (EXP)
testosterone  (EXP)
tetrachloromethane  (EXP,ISO)
tetracycline  (ISO)
tetrathiomolybdate(2-)  (ISO)
thioacetamide  (EXP)
thiourea  (ISO)
titanium atom  (EXP)
titanium dioxide  (EXP,ISO)
TMC-120A  (ISO)
topotecan  (EXP,ISO)
tramadol  (EXP)
transplatin  (ISO)
tremolite asbestos  (ISO)
trichloroethene  (EXP,ISO)
trichostatin A  (ISO)
triclosan  (ISO)
trimethyltin  (ISO)
troglitazone  (EXP,ISO)
tubocurarine  (ISO)
Tungsten carbide  (ISO)
uranium atom  (ISO)
urethane  (ISO)
valproic acid  (ISO)
valsartan  (EXP)
vanadyl sulfate  (EXP)
vancomycin  (EXP,ISO)
vitamin D  (ISO)
vitamin K  (EXP)
vorinostat  (ISO)
warfarin  (EXP,ISO)
zinc atom  (ISO)
zinc dichloride  (ISO)
zinc oxide  (EXP)
zinc(0)  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function


References - curated
# Reference Title Reference Citation
1. Upregulation of osteopontin in Schwann cells of the sciatic nerves of Lewis rats with experimental autoimmune neuritis. Ahn M, etal., Neurosci Lett. 2004 Nov 30;372(1-2):137-41.
2. Osteopontin transcription in aortic vascular smooth muscle cells is controlled by glucose-regulated upstream stimulatory factor and activator protein-1 activities. Bidder M, etal., J Biol Chem 2002 Nov 15;277(46):44485-96.
3. Aldosterone/salt induces renal inflammation and fibrosis in hypertensive rats. Blasi ER, etal., Kidney Int. 2003 May;63(5):1791-800.
4. Expression pattern of osteopontin in endometrial carcinoma: correlation with expression of the adhesion molecule CEACAM1. Briese J, etal., Int J Gynecol Pathol. 2006 Apr;25(2):161-9.
5. Telmisartan Prevents Alveolar Bone Loss by Decreasing the Expression of Osteoclasts Markers in Hypertensive Rats With Periodontal Disease. Brito VGB, etal., Front Pharmacol. 2020 Nov 11;11:579926. doi: 10.3389/fphar.2020.579926. eCollection 2020.
6. Overexpression of the cytokine osteopontin identifies aggressive laryngeal squamous cell carcinomas and enhances carcinoma cell proliferation and invasiveness. Celetti A, etal., Clin Cancer Res. 2005 Nov 15;11(22):8019-27.
7. The influence of the proinflammatory cytokine, osteopontin, on autoimmune demyelinating disease. Chabas D, etal., Science. 2001 Nov 23;294(5547):1731-5.
8. Osteopontin gene haplotypes correlate with multiple sclerosis development and progression. Chiocchetti A, etal., J Neuroimmunol. 2005 Jun;163(1-2):172-8. Epub 2005 Apr 25.
9. Human myeloma cells express the bone regulating gene Runx2/Cbfa1 and produce osteopontin that is involved in angiogenesis in multiple myeloma patients. Colla S, etal., Leukemia. 2005 Dec;19(12):2166-76.
10. Expression and regulation of osteopontin and connective tissue growth factor transcripts in rat anterior pituitary. Ehrchen J, etal., J Endocrinol. 2001 Apr;169(1):87-96.
11. Apatite plaque particles in inner medulla of kidneys of calcium oxalate stone formers: osteopontin localization. Evan AP, etal., Kidney Int. 2005 Jul;68(1):145-54.
12. Prognostic significance of osteopontin expression in human prostate cancer. Forootan SS, etal., Int J Cancer. 2006 May 1;118(9):2255-61.
13. Spinal root avulsion-induced upregulation of osteopontin expression in the adult rat spinal cord. Fu Y, etal., Acta Neuropathol (Berl). 2004 Jan;107(1):8-16. Epub 2003 Sep 26.
14. A polymorphism of the osteopontin gene is related to urinary calcium stones. Gao B, etal., J Urol. 2005 Oct;174(4 Pt 1):1472-6.
15. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
16. Differential regulation of osteopontin expression in the clipped and nonclipped kidney of two-kidney, one-clip hypertensive rats. Gauer S, etal., Am J Hypertens. 2003 Mar;16(3):214-22.
17. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
18. Osteopontin is overexpressed in human papillary thyroid carcinomas and enhances thyroid carcinoma cell invasiveness. Guarino V, etal., J Clin Endocrinol Metab. 2005 Sep;90(9):5270-8. Epub 2005 Jul 5.
19. Nitric oxide-dependent osteopontin expression induces metastatic behavior in HepG2 cells. Guo H, etal., Dig Dis Sci. 2005 Jul;50(7):1288-98.
20. Gene expression profiling of cathepsin D, metallothioneins-1 and -2, osteopontin, and tenascin-C in a mouse spinal cord injury model by cDNA microarray analysis. Hashimoto M, etal., Acta Neuropathol. 2005 Feb;109(2):165-80. Epub 2004 Dec 9.
21. Upregulation of osteopontin gene expression in diabetic rat proximal tubular cells revealed by microarray profiling. Hsieh TJ, etal., Kidney Int. 2006 Mar;69(6):1005-15.
22. Circulating interleukin-18 and osteopontin are useful to evaluate disease activity in patients with tuberculosis. Inomata S, etal., Cytokine. 2005 May 21;30(4):203-11.
23. Osteopontin plays an important role in the development of medial thickening and neointimal formation. Isoda K, etal., Circ Res. 2002 Jul 12;91(1):77-82.
24. Osteopontin expression in intratumoral astrocytes marks tumor progression in gliomas induced by prenatal exposure to N-ethyl-N-nitrosourea. Jang T, etal., Am J Pathol. 2006 May;168(5):1676-85.
25. Increased expression of osteopontin in the brain with scrapie infection. Jin JK, etal., Brain Res. 2006 Feb 9;1072(1):227-33. Epub 2006 Jan 17.
26. Increased expression of osteopontin gene in atypical teratoid/rhabdoid tumor of the central nervous system. Kao CL, etal., Mod Pathol. 2005 Jun;18(6):769-78.
27. High plasma levels of osteopontin in patients with restenosis after percutaneous coronary intervention. Kato R, etal., Arterioscler Thromb Vasc Biol. 2006 Jan;26(1):e1-2.
28. Progression of tubulointerstitial injury by osteopontin-induced macrophage recruitment in advanced diabetic nephropathy of transgenic (mRen-2)27 rats. Kelly DJ, etal., Nephrol Dial Transplant. 2002 Jun;17(6):985-91.
29. Middle East Respiratory Syndrome-Coronavirus Infection into Established hDPP4-Transgenic Mice Accelerates Lung Damage Via Activation of the Pro-Inflammatory Response and Pulmonary Fibrosis. Kim J, etal., J Microbiol Biotechnol. 2020 Mar 28;30(3):427-438. doi: 10.4014/jmb.1910.10055.
30. The expression of molecular mediators in the idiopathic cutaneous calcification and ossification. Kim SY, etal., J Cutan Pathol. 2008 Sep;35(9):826-31. doi: 10.1111/j.1600-0560.2007.00904.x. Epub 2008 Apr 18.
31. Osteopontin in kainic acid-induced microglial reactions in the rat brain. Kim SY, etal., Mol Cells. 2002 Jun 30;13(3):429-35.
32. In vitro and in vivo effects of the overexpression of osteopontin on osteoblast differentiation using a recombinant adenoviral vector. Kojima H, etal., J Biochem (Tokyo). 2004 Sep;136(3):377-86.
33. Osteopontin influences the invasiveness of pancreatic cancer cells and is increased in neoplastic and inflammatory conditions. Kolb A, etal., Cancer Biol Ther. 2005 Jul;4(7):740-6. Epub 2005 Jul 5.
34. Predictive genomic biomarkers for drug-induced nephrotoxicity in mice. Kondo C, etal., J Toxicol Sci. 2012;37(4):723-37.
35. Global gene expression profiling in early-stage polycystic kidney disease in the Han:SPRD Cy rat identifies a role for RXR signaling. Kugita M, etal., Am J Physiol Renal Physiol. 2011 Jan;300(1):F177-88. Epub 2010 Oct 6.
36. Osteopontin, a macrophage-derived matricellular glycoprotein, inhibits axon outgrowth. Kury P, etal., FASEB J. 2005 Mar;19(3):398-400. Epub 2004 Dec 29.
37. The dioxin/aryl hydrocarbon receptor mediates downregulation of osteopontin gene expression in a mouse model of gastric tumourigenesis. Kuznetsov NV, etal., Oncogene. 2005 Apr 28;24(19):3216-22.
38. High-density rat radiation hybrid maps containing over 24,000 SSLPs, genes, and ESTs provide a direct link to the rat genome sequence. Kwitek AE, etal., Genome Res. 2004 Apr;14(4):750-7
39. An evaluation of tumor oxygenation and gene expression in patients with early stage non-small cell lung cancers. Le QT, etal., Clin Cancer Res. 2006 Mar 1;12(5):1507-14.
40. Smooth muscle cells of the media in the dilatative pathology of ascending thoracic aorta: morphology, immunoreactivity for osteopontin, matrix metalloproteinases, and their inhibitors. Lesauskaite V, etal., Hum Pathol. 2001 Sep;32(9):1003-11.
41. P38 MAPK Signaling Pathway Mediates Angiotensin II-Induced miR143/145 Gene Cluster Downregulation during Aortic Dissection Formation. Li B, etal., Ann Vasc Surg. 2017 Apr;40:262-273. doi: 10.1016/j.avsg.2016.09.016. Epub 2017 Feb 4.
42. Osteopontin expression in normal and fibrotic liver. altered liver healing in osteopontin-deficient mice. Lorena D, etal., J Hepatol. 2006 Feb;44(2):383-90. Epub 2005 Aug 15.
43. The role of osteopontin in the development of albuminuria. Lorenzen J, etal., J Am Soc Nephrol. 2008 May;19(5):884-90.
44. Superoxide dismutase mimetic drug tempol aggravates anti-GBM antibody-induced glomerulonephritis in mice. Lu H, etal., Am J Physiol Renal Physiol. 2010 Aug;299(2):F445-52. Epub 2010 May 26.
45. Osteopontin participates in Th1-mediated host resistance against nonlethal malaria parasite Plasmodium chabaudi chabaudi infection in mice. Maeno Y, etal., Infect Immun. 2006 Apr;74(4):2423-7.
46. Osteopontin deficiency attenuates atherosclerosis in female apolipoprotein E-deficient mice. Matsui Y, etal., Arterioscler Thromb Vasc Biol. 2003 Jun 1;23(6):1029-34. Epub 2003 May 1.
47. Role of osteopontin in cardiac fibrosis and remodeling in angiotensin II-induced cardiac hypertrophy. Matsui Y, etal., Hypertension. 2004 Jun;43(6):1195-201. Epub 2004 May 3.
48. Dietary genistein improves survival and reduces expression of osteopontin in the prostate of transgenic mice with prostatic adenocarcinoma (TRAMP). Mentor-Marcel R, etal., J Nutr. 2005 May;135(5):989-95.
49. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
50. Integrin-linked kinase regulates osteopontin-dependent MMP-2 and uPA expression to convey metastatic function in murine mammary epithelial cancer cells. Mi Z, etal., Carcinogenesis. 2006 Jun;27(6):1134-45. Epub 2006 Feb 12.
51. Prognostic significance of plasma osteopontin levels in patients with chronic stable angina. Minoretti P, etal., Eur Heart J. 2006 Apr;27(7):802-7. Epub 2006 Jan 18.
52. Matrix vesicles are carriers of bone morphogenetic proteins (BMPs), vascular endothelial growth factor (VEGF), and noncollagenous matrix proteins. Nahar NN, etal., J Bone Miner Metab. 2008;26(5):514-9. Epub 2008 Aug 30.
53. SNPs in the promoter region of the osteopontin gene as a marker predicting the efficacy of interferon-based therapies in patients with chronic hepatitis C. Naito M, etal., J Gastroenterol. 2005 Apr;40(4):381-8.
54. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
55. Cloning and sequence analysis of rat bone sialoprotein (osteopontin) cDNA reveals an Arg-Gly-Asp cell-binding sequence. Oldberg A, etal., Proc Natl Acad Sci U S A 1986 Dec;83(23):8819-23.
56. Overexpression of MicroRNA-145 Promotes Ascending Aortic Aneurysm Media Remodeling through TGF-β1. Pei H, etal., Eur J Vasc Endovasc Surg. 2015 Jan;49(1):52-9. doi: 10.1016/j.ejvs.2014.10.018.
57. Osteopontin expression in coculture of differentiating rat fetal skeletal fibroblasts and myoblasts. Pereira RO, etal., In Vitro Cell Dev Biol Anim. 2006 Jan-Feb;42(1-2):4-7.
58. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
59. PID Annotation Import Pipeline Pipeline to import Pathway Interaction Database annotations from NCI into RGD
60. JNK1 differentially regulates osteopontin-induced nuclear factor-inducing kinase/MEKK1-dependent activating protein-1-mediated promatrix metalloproteinase-9 activation. Rangaswami H, etal., J Biol Chem. 2005 May 13;280(19):19381-92. Epub 2005 Mar 9.
61. Osteopontin posttranslational modifications, possibly phosphorylation, are required for in vitro bone resorption but not osteoclast adhesion. Razzouk S, etal., Bone. 2002 Jan;30(1):40-7.
62. GOA pipeline RGD automated data pipeline
63. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
64. Increased expression of osteopontin in the heart tissue of Lewis rats with experimental autoimmune myocarditis. Shin T, etal., J Vet Med Sci. 2006 Apr;68(4):379-82.
65. Uraemic hyperparathyroidism causes a reversible inflammatory process of aortic valve calcification in rats. Shuvy M, etal., Cardiovasc Res. 2008 Aug 1;79(3):492-9. Epub 2008 Apr 5.
66. Differential processing of osteopontin transcripts in rat kidney- and osteoblast-derived cell lines. Singh K, etal., J Biol Chem 1992 Nov 25;267(33):23847-51.
67. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, etal., Proc Natl Acad Sci U S A. 2002 Dec 24;99(26):16899-903. Epub 2002 Dec 11.
68. Colocalization of intracellular osteopontin with CD44 is associated with migration, cell fusion, and resorption in osteoclasts. Suzuki K, etal., J Bone Miner Res 2002 Aug;17(8):1486-97.
69. Osteopontin expression in proliferated bile ductules: the correlation with liver damage in fulminant hepatitis. Tajiri T, etal., Dig Dis Sci. 2005 Jan;50(1):188-95.
70. Osteopontin induces angiogenesis of murine neuroblastoma cells in mice. Takahashi F, etal., Int J Cancer. 2002 Apr 10;98(5):707-12.
71. Osteopontin is released from the heart into the coronary circulation in patients with a previous anterior wall myocardial infarction. Tamura A, etal., Circ J. 2003 Sep;67(9):742-4.
72. Tentative Sequence Identification Numbers Tentative Sequence Data IDs. TIGR Gene Index, Rat Data
73. The role of osteopontin in foreign body giant cell formation. Tsai AT, etal., Biomaterials. 2005 Oct;26(29):5835-43. Epub 2005 Apr 21.
74. Aprt/Opn double knockout mice: osteopontin is a modifier of kidney stone disease severity. Vernon HJ, etal., Kidney Int. 2005 Sep;68(3):938-47.
75. Comprehensive Molecular Analyses of a Macrophage-Related Gene Signature With Regard to Prognosis, Immune Features, and Biomarkers for Immunotherapy in Hepatocellular Carcinoma Based on WGCNA and the LASSO Algorithm. Wang T, etal., Front Immunol. 2022 May 27;13:843408. doi: 10.3389/fimmu.2022.843408. eCollection 2022.
76. Osteopontin: a rapid and sensitive response to dioxin exposure in the osteoblastic cell line UMR-106. Wejheden C, etal., Biochem Biophys Res Commun. 2006 Mar 3;341(1):116-20. Epub 2006 Jan 6.
77. Expression of osteopontin correlates with portal biliary proliferation and fibrosis in biliary atresia. Whitington PF, etal., Pediatr Res. 2005 Jun;57(6):837-44. Epub 2005 Apr 21.
78. Administration of colony stimulating factor-1 to toothless osteopetrotic rats normalizes osteoblast, but not osteoclast, gene expression. Wisner-Lynch LA, etal., Bone. 1995 Jun;16(6):611-8. doi: 10.1016/8756-3282(95)00114-s.
79. Osteopontin modulates myocardial hypertrophy in response to chronic pressure overload in mice. Xie Z, etal., Hypertension. 2004 Dec;44(6):826-31. Epub 2004 Nov 8.
80. Osteopontin inhibits interleukin-1beta-stimulated increases in matrix metalloproteinase activity in adult rat cardiac fibroblasts: role of protein kinase C-zeta. Xie Z, etal., J Biol Chem. 2003 Dec 5;278(49):48546-52. Epub 2003 Sep 18.
81. Role of osteopontin in amplification and perpetuation of rheumatoid synovitis. Xu G, etal., J Clin Invest. 2005 Apr;115(4):1060-7. Epub 2005 Mar 3.
82. Plasma concentrations of osteopontin, but not thrombin-cleaved osteopontin, are associated with the presence and severity of nephropathy and coronary artery disease in patients with type 2 diabetes mellitus. Yan X, etal., Cardiovasc Diabetol. 2010 Oct 29;9:70.
83. Proteomic-based discovery and characterization of glycosylated eosinophil-derived neurotoxin and COOH-terminal osteopontin fragments for ovarian cancer in urine. Ye B, etal., Clin Cancer Res. 2006 Jan 15;12(2):432-41.
84. Osteopontin gene is expressed in the dermal papilla of pelage follicles in a hair-cycle-dependent manner. Yu DW, etal., J Invest Dermatol 2001 Dec;117(6):1554-8.
85. Spotlight on differentially expressed genes in urinary bladder cancer. Zaravinos A, etal., PLoS One. 2011 Apr 5;6(4):e18255.
86. Downregulation of miR143/145 gene cluster expression promotes the aortic media degeneration process via the TGF-β1 signaling pathway. Zhang M and Wang Z, Am J Transl Res. 2019 Jan 15;11(1):370-378. eCollection 2019.
87. Osteopontin expressed in tubular epithelial cells regulates NK cell-mediated kidney ischemia reperfusion injury. Zhang ZX, etal., J Immunol. 2010 Jul 15;185(2):967-73. Epub 2010 Jun 14.
88. Blockade of osteopontin inhibits glomerular fibrosis in a model of anti-glomerular basement membrane glomerulonephritis. Zhou C, etal., Am J Nephrol. 2010;32(4):324-31. Epub 2010 Aug 19.
89. Synthesis and processing of bone sialoproteins during de novo bone formation in vitro. Zhu XL, etal., Biochem Cell Biol 2001;79(6):737-46.
90. Increased cell death in osteopontin-deficient cardiac fibroblasts occurs by a caspase-3-independent pathway. Zohar R, etal., Am J Physiol Heart Circ Physiol. 2004 Oct;287(4):H1730-9. Epub 2004 May 27.
91. Effect of NADPH oxidase inhibition on the expression of kidney injury molecule and calcium oxalate crystal deposition in hydroxy-L-proline-induced hyperoxaluria in the male Sprague-Dawley rats. Zuo J, etal., Nephrol Dial Transplant. 2011 Jun;26(6):1785-96. Epub 2011 Mar 4.
Additional References at PubMed
PMID:2736258   PMID:3167835   PMID:3469201   PMID:8408622   PMID:8889548   PMID:11967208   PMID:12505755   PMID:15121739   PMID:15153550   PMID:15482851   PMID:15489334   PMID:15516325  
PMID:15548430   PMID:15557322   PMID:15865444   PMID:16187297   PMID:16253490   PMID:16502470   PMID:16518820   PMID:16720713   PMID:16753026   PMID:16807234   PMID:16883060   PMID:17546625  
PMID:17643430   PMID:17868879   PMID:17898038   PMID:17973907   PMID:18036861   PMID:18041732   PMID:18158341   PMID:18180311   PMID:18235026   PMID:18378437   PMID:18415800   PMID:18471361  
PMID:18638458   PMID:18703563   PMID:18703867   PMID:18712054   PMID:18728346   PMID:18757743   PMID:19032867   PMID:19076167   PMID:19124839   PMID:19686792   PMID:19723557   PMID:19901966  
PMID:20211246   PMID:20392802   PMID:20396353   PMID:20407481   PMID:20417179   PMID:20439489   PMID:20450731   PMID:20596651   PMID:20626561   PMID:20714131   PMID:20838370   PMID:21264948  
PMID:21283687   PMID:21321126   PMID:21806466   PMID:21940634   PMID:21949681   PMID:22036853   PMID:22049796   PMID:22087764   PMID:22496158   PMID:22552891   PMID:22692550   PMID:22779921  
PMID:22814749   PMID:22847642   PMID:23161527   PMID:23241663   PMID:23376485   PMID:23457612   PMID:23466073   PMID:23467880   PMID:23498805   PMID:23533145   PMID:23788374   PMID:24247243  
PMID:24449951   PMID:24687376   PMID:24841674   PMID:25146847   PMID:25467747   PMID:25839998   PMID:26099282   PMID:26216642   PMID:26482249   PMID:26581507   PMID:27026710   PMID:27089830  
PMID:27262843   PMID:27486809   PMID:27585571   PMID:27659347   PMID:27717860   PMID:27743892   PMID:28270094   PMID:28302392   PMID:28442375   PMID:28978514   PMID:29337251   PMID:29602294  
PMID:30758811   PMID:30893567   PMID:31544532   PMID:31914633   PMID:32061643   PMID:32271401   PMID:32423114   PMID:33645892   PMID:33678127   PMID:33883409   PMID:34510519   PMID:35688947  
PMID:36413180   PMID:36646166   PMID:36913234   PMID:38081614   PMID:38415922  


Comparative Map Data
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
GRCr8145,613,569 - 5,620,695 (-)NCBIGRCr8
mRatBN7.2145,308,885 - 5,315,120 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl145,308,885 - 5,315,162 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx145,269,750 - 5,275,787 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0146,569,945 - 6,575,982 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0145,261,625 - 5,267,707 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0146,673,686 - 6,679,965 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl146,673,686 - 6,679,901 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0146,653,086 - 6,658,937 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.1146,422,741 - 6,426,400 (-)NCBI
Celera145,447,814 - 5,453,553 (-)NCBICelera
RH 3.4 Map1484.5RGD
Cytogenetic Map14p22NCBI
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
GRCh38487,975,714 - 87,983,411 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl487,975,667 - 87,983,532 (+)EnsemblGRCh38hg38GRCh38
GRCh37488,896,866 - 88,904,563 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36489,115,826 - 89,123,587 (+)NCBINCBI36Build 36hg18NCBI36
Build 34489,253,980 - 89,261,741NCBI
Celera486,188,727 - 86,196,490 (+)NCBICelera
Cytogenetic Map4q22.1NCBI
HuRef484,643,231 - 84,650,994 (+)NCBIHuRef
CHM1_1488,873,591 - 88,881,352 (+)NCBICHM1_1
T2T-CHM13v2.0491,302,203 - 91,309,899 (+)NCBIT2T-CHM13v2.0
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
GRCm395104,582,977 - 104,588,919 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl5104,582,984 - 104,588,916 (+)EnsemblGRCm39 Ensembl
GRCm385104,435,111 - 104,441,053 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl5104,435,118 - 104,441,050 (+)EnsemblGRCm38mm10GRCm38
MGSCv375104,864,137 - 104,870,069 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv365104,657,300 - 104,681,345 (+)NCBIMGSCv36mm8
Celera5101,744,286 - 101,750,760 (+)NCBICelera
Cytogenetic Map5E5NCBI
cM Map550.68NCBI
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
ChiLan1.0 EnsemblNW_0049554741,913,829 - 1,922,016 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049554741,914,477 - 1,922,025 (-)NCBIChiLan1.0ChiLan1.0
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
NHGRI_mPanPan1-v2385,977,678 - 85,985,354 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1486,240,086 - 86,247,760 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0480,263,711 - 80,271,466 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1490,988,200 - 90,995,935 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl490,988,200 - 90,995,935 (+)Ensemblpanpan1.1panPan2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
CanFam3.13211,354,070 - 11,362,325 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl3211,353,953 - 11,362,069 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha3230,592,131 - 30,600,371 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.03211,406,381 - 11,414,630 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl3211,406,395 - 11,414,631 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.13211,490,535 - 11,498,773 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.03211,316,506 - 11,324,744 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.03228,630,350 - 28,638,599 (-)NCBIUU_Cfam_GSD_1.0
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
HiC_Itri_2NW_0244052851,729,610 - 1,736,282 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_004936905148,945 - 156,079 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_004936905148,956 - 156,023 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
Sscrofa11.1 Ensembl8131,077,786 - 131,085,340 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.18131,077,786 - 131,085,334 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.28140,307,933 - 140,315,453 (-)NCBISscrofa10.2Sscrofa10.2susScr3
Pig Cytomap8qNCBI
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
ChlSab1.1736,337,165 - 36,344,927 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl736,338,386 - 36,344,407 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366603715,089,529 - 15,097,556 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
HetGla_female_1.0 EnsemblNW_0046248724,505,522 - 4,513,742 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046248724,505,796 - 4,513,247 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2


Variants in Spp1
73 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:400
Count of miRNA genes:226
Interacting mature miRNAs:264
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.

QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
2300159Bmd61Bone mineral density QTL 615.30.0001femur mineral mass (VT:0010011)volumetric bone mineral density (CMO:0001553)14126541967Rat
2300183Bmd60Bone mineral density QTL 605.70.0001femur mineral mass (VT:0010011)volumetric bone mineral density (CMO:0001553)14126541967Rat
619619Rf4Renal disease susceptibility QTL 44.10.002urine total protein amount (VT:0000032)urine protein excretion rate to body weight ratio (CMO:0001099)14132754612Rat
634352Apr6Acute phase response QTL 63.7blood interleukin-6 amount (VT:0008595)plasma interleukin-6 level (CMO:0001927)14141131407Rat
71115Niddm15Non-insulin dependent diabetes mellitus QTL 154.8blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)14121760611030812Rat
70204Niddm20Non-insulin dependent diabetes mellitus QTL 205.10.000008blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)14121760616960180Rat
724541Niddm53Non-insulin dependent diabetes mellitus QTL 530.001blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)1438130749088978Rat
2293089Iddm31Insulin dependent diabetes mellitus QTL 314.7blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)14381307418274691Rat
2293089Iddm31Insulin dependent diabetes mellitus QTL 314.7blood glucose amount (VT:0000188)age at onset/diagnosis of type 1 diabetes mellitus (CMO:0001140)14381307418274691Rat
1300114Srn2Serum renin concentration QTL 23.27blood renin amount (VT:0003349)plasma renin activity level (CMO:0000116)14381307421217635Rat
70195Mcs8Mammary carcinoma susceptibility QTL 84.28mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)14381307424531477Rat
1331740Bw26Body weight QTL 263.028body mass (VT:0001259)body weight (CMO:0000012)14381307430767156Rat

Markers in Region
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2145,309,008 - 5,309,173 (+)MAPPERmRatBN7.2
Rnor_6.0146,673,810 - 6,673,974NCBIRnor6.0
Rnor_5.0146,653,210 - 6,653,374UniSTSRnor5.0
Celera145,447,938 - 5,448,102UniSTS
RH 3.4 Map1484.5UniSTS
Cytogenetic Map14p22UniSTS
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2145,309,016 - 5,309,234 (+)MAPPERmRatBN7.2
Rnor_6.0146,673,818 - 6,674,035NCBIRnor6.0
Rnor_5.0146,653,218 - 6,653,435UniSTSRnor5.0
Celera145,447,946 - 5,448,163UniSTS
Cytogenetic Map14p22UniSTS
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2145,308,890 - 5,309,100 (+)MAPPERmRatBN7.2
Rnor_6.0146,673,692 - 6,673,901NCBIRnor6.0
Rnor_5.0146,653,092 - 6,653,301UniSTSRnor5.0
Celera145,447,820 - 5,448,029UniSTS
RH 3.4 Map1488.1UniSTS
Cytogenetic Map14p22UniSTS
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2145,309,424 - 5,309,769 (+)MAPPERmRatBN7.2
Rnor_6.0146,674,226 - 6,674,570NCBIRnor6.0
Rnor_5.0146,653,626 - 6,653,970UniSTSRnor5.0
Celera145,448,354 - 5,448,698UniSTS
Cytogenetic Map14p22UniSTS
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2145,310,624 - 5,312,028 (+)MAPPERmRatBN7.2
Rnor_6.0146,675,426 - 6,676,829NCBIRnor6.0
Rnor_5.0146,654,826 - 6,656,229UniSTSRnor5.0
RGSC_v3.4146,423,677 - 6,425,080UniSTSRGSC3.4
Celera145,449,554 - 5,450,957UniSTS
Cytogenetic Map14p22UniSTS

Genetic Models
This gene Spp1 is modified in the following models/strains:


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High 1
Medium 20 8 26 34 21 2
Low 2 21 41 33 16 33 8 10 48 20 9 8
Below cutoff 1 2 8 8 2 8 1


RefSeq Acc Id: ENSRNOT00000067875   ⟹   ENSRNOP00000062358
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl145,308,885 - 5,315,162 (-)Ensembl
Rnor_6.0 Ensembl146,673,686 - 6,679,901 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000075989   ⟹   ENSRNOP00000068511
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl145,308,890 - 5,315,139 (-)Ensembl
Rnor_6.0 Ensembl146,673,746 - 6,679,878 (-)Ensembl
RefSeq Acc Id: NM_012881   ⟹   NP_037013
RefSeq Status: VALIDATED
Rat AssemblyChrPosition (strand)Source
GRCr8145,613,569 - 5,619,804 (-)NCBI
mRatBN7.2145,308,885 - 5,315,120 (-)NCBI
Rnor_6.0146,673,686 - 6,679,921 (-)NCBI
Rnor_5.0146,653,086 - 6,658,937 (-)NCBI
Celera145,447,814 - 5,453,553 (-)RGD
RefSeq Acc Id: XM_008769996   ⟹   XP_008768218
Rat AssemblyChrPosition (strand)Source
GRCr8145,613,569 - 5,619,801 (-)NCBI
mRatBN7.2145,308,885 - 5,315,117 (-)NCBI
Rnor_6.0146,673,686 - 6,679,965 (-)NCBI
RefSeq Acc Id: XM_063272870   ⟹   XP_063128940
Rat AssemblyChrPosition (strand)Source
GRCr8145,613,569 - 5,620,695 (-)NCBI
RefSeq Acc Id: NP_037013   ⟸   NM_012881
- Peptide Label: precursor
- UniProtKB: P08721 (UniProtKB/Swiss-Prot),   A6K5R7 (UniProtKB/TrEMBL),   P97827 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_008768218   ⟸   XM_008769996
- Peptide Label: isoform X1
- UniProtKB: P08721 (UniProtKB/Swiss-Prot),   A6K5R7 (UniProtKB/TrEMBL),   P97827 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSRNOP00000062358   ⟸   ENSRNOT00000067875
RefSeq Acc Id: ENSRNOP00000068511   ⟸   ENSRNOT00000075989
RefSeq Acc Id: XP_063128940   ⟸   XM_063272870
- Peptide Label: isoform X1

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P08721-F1-model_v2 AlphaFold P08721 1-317 view protein structure


eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

RGD ID:13699171
Promoter ID:EPDNEW_R9696
Type:multiple initiation site
Description:secreted phosphoprotein 1
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Rat AssemblyChrPosition (strand)Source
Rnor_6.0146,679,910 - 6,679,970EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:3752 AgrOrtholog
BioCyc Gene G2FUF-16513 BioCyc
Ensembl Genes ENSRNOG00000043451 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ENSRNOG00065012697 UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000067875 ENTREZGENE
  ENSRNOT00000067875.5 UniProtKB/Swiss-Prot
  ENSRNOT00000075989.2 UniProtKB/TrEMBL
  ENSRNOT00065020692 UniProtKB/Swiss-Prot
InterPro Osteopontin UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Osteopontin_CS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:25353 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PTHR10607 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam Osteopontin UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Spp1 PhenoGen
RatGTEx ENSRNOG00000043451 RatGTEx
  ENSRNOG00065012697 RatGTEx
SMART OSTEO UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
TIGR TC216845

Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2013-03-29 Spp1  secreted phosphoprotein 1  LOC100359743  osteopontin-like  Data merged from RGD:2323497 737654 PROVISIONAL
2010-05-06 LOC100359743  osteopontin-like      Symbol and Name status set to provisional 70820 PROVISIONAL
2002-06-10 Spp1  secreted phosphoprotein 1      Name updated 70584 APPROVED

RGD Curation Notes
Note Type Note Reference
gene_cellular_localization intracellular form colocalizes with CD44 730240
gene_expression expressed in osteoclasts 730240
gene_expression expressed in osteosarcoma cell line ROS 17/2.8 70021
gene_expression expressed in normal kidney cells and expressed at a lower level in Kirsten sarcoma virus-transformed kidney cells 729935
gene_expression expressed in vibrissa dermal papilla (hair follicle cells) but not detected in cultured skin fibroblasts 1299048
gene_function extracellular matrix protein that binds cells 70021
gene_process may serve to aggregate dermal papilla cells and may protect dermal papilla cells from cytokine- or hypoxia-induced apoptosis 1299048
gene_protein 317 amino acid protein; may be both O- and N-glycosylated 70021
gene_transcript alternative transcript produced in kidney cells which is not expressed in osteosarcoma cells 729935