Spn (sialophorin) - Rat Genome Database

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Gene: Spn (sialophorin) Rattus norvegicus
Analyze
Symbol: Spn
Name: sialophorin
RGD ID: 3750
Description: Enables protein domain specific binding activity. Involved in several processes, including T cell receptor signaling pathway; monocyte activation; and thymocyte aggregation. Located in cell surface; cleavage furrow; and microvillus. Orthologous to human SPN (sialophorin); INTERACTS WITH 17beta-estradiol; 2,3,7,8-tetrachlorodibenzodioxine; 4-amino-2,6-dinitrotoluene.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: Cd43; gpL115; leukocyte sialoglycoprotein; Leukosialin; leukosianin; Lsn; Lsn1; Sialophorin (gpL115 leukosianin CD43); Sialophorin (gpL115, leukosianin, CD43); W3/13 antigen
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Is Marker For: QTLs:   Bp43   Pancm1   Iddm10   Bp84  
Candidate Gene For: Pancm1
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.21181,746,937 - 181,759,564 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1181,746,429 - 181,759,628 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1190,098,274 - 190,102,501 (-)NCBIRnor_SHR
UTH_Rnor_SHRSP_BbbUtx_1.01197,284,362 - 197,288,589 (-)NCBIRnor_SHRSP
UTH_Rnor_WKY_Bbb_1.01189,953,011 - 189,957,242 (-)NCBIRnor_WKY
Rnor_6.01198,572,999 - 198,585,664 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1198,572,999 - 198,577,226 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01205,563,659 - 205,576,290 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41186,388,120 - 186,391,887 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11186,538,248 - 186,541,733 (-)NCBI
Celera1179,399,985 - 179,404,212 (-)NCBICelera
Cytogenetic Map1q37NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
1,2-dichloroethane  (ISO)
1,2-dimethylhydrazine  (ISO)
17beta-estradiol  (EXP,ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
4-amino-2,6-dinitrotoluene  (EXP)
5-fluorouracil  (ISO)
6-propyl-2-thiouracil  (EXP)
acetamide  (EXP)
aflatoxin B1  (EXP)
Aflatoxin B2 alpha  (ISO)
ammonium chloride  (EXP)
amphetamine  (EXP)
antirheumatic drug  (ISO)
atropine  (ISO)
aurantio-obtusin  (ISO)
benzo[a]pyrene  (ISO)
Benzo[k]fluoranthene  (ISO)
bisphenol A  (EXP)
bortezomib  (ISO)
cadmium dichloride  (EXP)
carbon nanotube  (ISO)
chloroprene  (EXP,ISO)
chlorpyrifos  (ISO)
chromium(6+)  (ISO)
cisplatin  (EXP)
copper atom  (EXP)
copper(0)  (EXP)
Cuprizon  (EXP)
dextran sulfate  (ISO)
dicrotophos  (ISO)
digitonin  (ISO)
doxorubicin  (ISO)
ethanol  (EXP)
folic acid  (ISO)
gadodiamide hydrate  (ISO)
genistein  (ISO)
gentamycin  (EXP)
lipopolysaccharide  (ISO)
mercury dichloride  (ISO)
methyl methanesulfonate  (ISO)
metoprolol  (ISO)
N(gamma)-nitro-L-arginine methyl ester  (EXP)
naringin  (EXP)
nickel atom  (ISO)
ozone  (ISO)
paracetamol  (ISO)
paraquat  (EXP)
prazosin  (ISO)
progesterone  (ISO)
raloxifene  (EXP)
S-(1,2-dichlorovinyl)-L-cysteine  (ISO)
silicon dioxide  (ISO)
silver atom  (ISO)
silver(0)  (ISO)
thioacetamide  (EXP)
titanium dioxide  (ISO)
triclosan  (ISO)
trimellitic anhydride  (ISO)
trimethaphan  (ISO)
triptonide  (ISO)
tropan-3alpha-yl 3-hydroxy-2-phenylpropanoate  (ISO)
trovafloxacin  (ISO)
tungsten  (ISO)
valproic acid  (ISO)
venlafaxine hydrochloride  (EXP)
vinclozolin  (EXP)
zinc atom  (ISO)
zinc(0)  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Identification of two subpopulations of rat monocytes expressing disparate molecular forms and quantities of CD43. Ahuja V, etal., Cell Immunol. 1995 Jun;163(1):59-69.
2. Protective role of sialophorin (CD43)-expressing cells in experimental Staphylococcus aureus infection. Bremell T, etal., Infect Immun. 1994 Oct;62(10):4637-40.
3. Genetic modifiers of Leprfa associated with variability in insulin production and susceptibility to NIDDM. Chung WK, etal., Genomics 1997 May 1;41(3):332-44
4. The importance of cross-linking in the homotypic aggregation of lymphocytes induced by anti-leukosialin (CD43) antibodies. Cyster JG and Williams AF, Eur J Immunol. 1992 Oct;22(10):2565-72.
5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
6. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
7. CD45 ectodomain controls interaction with GEMs and Lck activity for optimal TCR signaling. Irles C, etal., Nat Immunol 2003 Feb;4(2):189-97. Epub 2002 Dec 23.
8. The sequence of rat leukosialin (W3/13 antigen) reveals a molecule with O-linked glycosylation of one third of its extracellular amino acids. Killeen N, etal., EMBO J 1987 Dec 20;6(13):4029-34.
9. Novel quantitative trait loci for blood pressure and related traits on rat chromosomes 1, 10, and 18. Kovacs P, etal., Biochem Biophys Res Commun 1997 Jun 18;235(2):343-8
10. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
11. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
12. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
13. GOA pipeline RGD automated data pipeline
14. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
15. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
16. Rat monocytes up-regulate NKR-P1A and down-modulate CD4 and CD43 during activation in vivo: monocyte subpopulations in normal and IFN-gamma-treated rats. Scriba A, etal., J Leukoc Biol. 1997 Dec;62(6):741-52.
17. An antiserum raised against the recombinant cytoplasmic tail of the human CD43 glycoprotein identifies CD43 in many mammalian species. Szlanka T, etal., Immunology. 1999 Jan;96(1):74-82.
18. Structural basis of the cytoplasmic tail of adhesion molecule CD43 and its binding to ERM proteins. Takai Y, etal., J Mol Biol. 2008 Sep 5;381(3):634-44. Epub 2008 Jun 7.
19. Tentative Sequence Identification Numbers Tentative Sequence Data IDs. TIGR Gene Index, Rat Data
20. PECAM-1 and leukosialin (CD43) expression correlate with heightened inflammation in rat adjuvant-induced arthritis. Volin MV, etal., Exp Mol Pathol. 1999 Aug;66(3):211-9.
21. Concentration of an integral membrane protein, CD43 (leukosialin, sialophorin), in the cleavage furrow through the interaction of its cytoplasmic domain with actin-based cytoskeletons. Yonemura S, etal., J Cell Biol. 1993 Jan;120(2):437-49.
22. Ezrin/radixin/moesin (ERM) proteins bind to a positively charged amino acid cluster in the juxta-membrane cytoplasmic domain of CD44, CD43, and ICAM-2. Yonemura S, etal., J Cell Biol. 1998 Feb 23;140(4):885-95.
23. Functional characterization of Delta3,Delta2-enoyl-CoA isomerases from rat liver. Zhang D, etal., J Biol Chem. 2002 Mar 15;277(11):9127-32. Epub 2002 Jan 7.
Additional References at PubMed
PMID:7477353   PMID:7514104   PMID:7566153   PMID:7790813   PMID:7795661   PMID:8920854   PMID:9645617   PMID:10429671   PMID:10899905   PMID:10943842   PMID:11238599   PMID:11380685  
PMID:11728336   PMID:11828253   PMID:11937524   PMID:11994475   PMID:12354383   PMID:14635057   PMID:15117976   PMID:15843532   PMID:17221298   PMID:17638845   PMID:18036228   PMID:19299737  
PMID:19946888   PMID:20333395   PMID:20360400   PMID:20458337   PMID:20605918   PMID:20633027   PMID:21289089   PMID:24250818   PMID:26700769  


Genomics

Comparative Map Data
Spn
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.21181,746,937 - 181,759,564 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1181,746,429 - 181,759,628 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1190,098,274 - 190,102,501 (-)NCBIRnor_SHR
UTH_Rnor_SHRSP_BbbUtx_1.01197,284,362 - 197,288,589 (-)NCBIRnor_SHRSP
UTH_Rnor_WKY_Bbb_1.01189,953,011 - 189,957,242 (-)NCBIRnor_WKY
Rnor_6.01198,572,999 - 198,585,664 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1198,572,999 - 198,577,226 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01205,563,659 - 205,576,290 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41186,388,120 - 186,391,887 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11186,538,248 - 186,541,733 (-)NCBI
Celera1179,399,985 - 179,404,212 (-)NCBICelera
Cytogenetic Map1q37NCBI
SPN
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381629,662,963 - 29,670,876 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p13 Ensembl1629,662,979 - 29,670,876 (+)EnsemblGRCh38hg38GRCh38
GRCh371629,674,284 - 29,682,197 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361629,581,801 - 29,589,329 (+)NCBINCBI36Build 36hg18NCBI36
Build 34864,262,738 - 64,263,150NCBI
Celera1673,114,178 - 73,121,702 (-)NCBICelera
Cytogenetic Map16p11.2NCBI
HuRef1627,335,753 - 27,343,116 (+)NCBIHuRef
CHM1_11630,686,100 - 30,693,653 (+)NCBICHM1_1
T2T-CHM13v2.01629,945,006 - 29,952,917 (+)NCBIT2T-CHM13v2.0
Spn
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm397126,731,404 - 126,743,785 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl7126,731,404 - 126,736,995 (-)EnsemblGRCm39 Ensembl
GRCm387127,123,637 - 127,145,552 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl7127,132,232 - 127,137,823 (-)EnsemblGRCm38mm10GRCm38
MGSCv377134,276,978 - 134,281,331 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv367126,924,612 - 126,928,965 (-)NCBIMGSCv36mm8
Celera7126,982,004 - 126,986,358 (-)NCBICelera
Cytogenetic Map7F3NCBI
cM Map769.35NCBI
Spn
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0NW_0049554937,256,505 - 7,258,607 (-)NCBIChiLan1.0ChiLan1.0
SPN
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.11630,034,739 - 30,037,033 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1630,035,243 - 30,036,445 (+)Ensemblpanpan1.1panPan2
SPN
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1617,770,303 - 17,774,946 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha619,347,439 - 19,352,997 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0617,904,551 - 17,908,967 (+)NCBIROS_Cfam_1.0
UMICH_Zoey_3.1617,704,496 - 17,710,054 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0617,619,970 - 17,625,528 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0617,935,701 - 17,941,231 (+)NCBIUU_Cfam_GSD_1.0
Spn
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024409344124,676,088 - 124,678,845 (-)NCBIHiC_Itri_2
SpeTri2.0NW_00493650112,773,967 - 12,776,642 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
SPN
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl317,978,801 - 17,982,864 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1317,978,731 - 17,982,222 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2318,608,470 - 18,612,200 (-)NCBISscrofa10.2Sscrofa10.2susScr3
SPN
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1526,987,810 - 26,990,214 (-)NCBIChlSab1.1ChlSab1.1chlSab2
Vero_WHO_p1.0NW_0236660682,533,410 - 2,535,788 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Spn
(Heterocephalus glaber - naked mole-rat)
Naked Mole-rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_00462478213,471,083 - 13,483,712 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Spn
71 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:60
Count of miRNA genes:52
Interacting mature miRNAs:57
Transcripts:ENSRNOT00000055013
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
10059597Bp377Blood pressure QTL 3773.420.025arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)132737458199368955Rat
634314Niddm44Non-insulin dependent diabetes mellitus QTL 44blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)149393289199050459Rat
1578780Cm52Cardiac mass QTL 523.30.0001heart mass (VT:0007028)heart wet weight (CMO:0000069)181591954219808434Rat
1331751Bp199Blood pressure QTL 1993.60022arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)194494440181830018Rat
1331749Hrtrt11Heart rate QTL 112.973heart pumping trait (VT:2000009)heart rate (CMO:0000002)194494440198211706Rat
70209Niddm23Non-insulin dependent diabetes mellitus QTL 232.82blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)194494440198324465Rat
731168Bp154Blood pressure QTL 1543.4arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)194642722214537671Rat
8655649Arrd1Age-related retinal degeneration QTL 14.89retinal layer morphology trait (VT:0003727)percentage of study population developing retinopathy during a period of time (CMO:0002453)1100357752183970443Rat
1354591Cm36Cardiac mass QTL 364.1heart left ventricle mass (VT:0007031)calculated heart weight (CMO:0000073)1102813953201278233Rat
1354615Cm32Cardiac mass QTL 325.2heart left ventricle mass (VT:0007031)heart left ventricle wet weight (CMO:0000071)1102813953201278233Rat
1354606Bp246Blood pressure QTL 2463.6arterial blood pressure trait (VT:2000000)pulse pressure (CMO:0000292)1102813953218753816Rat
1300158Bp173Blood pressure QTL 1733.48arterial blood pressure trait (VT:2000000)blood pressure time series experimental set point of the baroreceptor response (CMO:0002593)1115540693185145286Rat
7794788Mcs32Mammary carcinoma susceptibility QTL 322.61mammary gland integrity trait (VT:0010552)mammary tumor incidence/prevalence measurement (CMO:0000946)1115540693238914717Rat
7421630Bp362Blood pressure QTL 3620.001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)1118608292241799120Rat
631205Bp196Blood pressure QTL 19640.0001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)1118944897199050459Rat
631544Bp84Blood pressure QTL 845.6arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1123350408181759564Rat
1358189Cstrr1Cold stress response QTL 10.0001catecholamine amount (VT:0010543)urine norepinephrine level (CMO:0001629)1123350408182418476Rat
1641895Bp298Blood pressure QTL 298arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)1123350408182418476Rat
1578770Stresp23Stress response QTL 23kidney sympathetic nerve activity (VT:0004050)stimulated renal sympathetic nerve activity to basal renal sympathetic nerve activity ratio (CMO:0001786)1123350408182418476Rat
631549Bp89Blood pressure QTL 895.7arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1123350581201284552Rat
71118Thym1Thymus enlargement QTL 110.170.001thymus mass (VT:0004954)thymus weight to body weight ratio (CMO:0000612)1136829932181829932Rat
724550Thym3Thymus enlargement QTL 37.820.001thymus mass (VT:0004954)thymus weight to body weight ratio (CMO:0000612)1136829932181829932Rat
631519Pia11Pristane induced arthritis QTL 115.3joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1136830018181830018Rat
1598853Memor3Memory QTL 34.5exploratory behavior trait (VT:0010471)total horizontal distance resulting from voluntary locomotion in an experimental apparatus (CMO:0001443)1143506580212458660Rat
61348Bp30Blood pressure QTL 302.4arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1144017057197814409Rat
70160Bw18Body weight QTL 185.7body mass (VT:0001259)body weight (CMO:0000012)1144267353196383635Rat
737828Hcas3Hepatocarcinoma susceptibility QTL 34.9liver integrity trait (VT:0010547)liver tumorous lesion volume to total liver volume ratio (CMO:0001082)1144267353222987745Rat
2302378Insul11Insulin level QTL 113.25blood insulin amount (VT:0001560)serum insulin level (CMO:0000358)1144267353251128347Rat
7771612Cm80Cardiac mass QTL 808.4heart left ventricle mass (VT:0007031)heart left ventricle weight (CMO:0000776)1149448574221264292Rat
724531Uae5Urinary albumin excretion QTL 54urine albumin amount (VT:0002871)urine albumin level (CMO:0000130)1150700142252085212Rat
1578759Uae30Urinary albumin excretion QTL 303.30.003urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)1150700247252085048Rat
1578778Pur4Proteinuria QTL 43.30.003urine total protein amount (VT:0000032)urine total protein excretion rate (CMO:0000756)1150700247252085048Rat
1354602Bw35Body weight QTL 3512.2body mass (VT:0001259)body weight (CMO:0000012)1151162512201278233Rat
1354620Kidm19Kidney mass QTL 194kidney mass (VT:0002707)calculated kidney weight (CMO:0000160)1151162512201278233Rat
1354634Kidm12Kidney mass QTL 123.9kidney mass (VT:0002707)right kidney wet weight (CMO:0000082)1151162512201278233Rat
1354636Lmblg1Limb length QTL 16.4tibia length (VT:0004357)tibia length (CMO:0000450)1151162512201278233Rat
1354610Bw34Body weight QTL 344.1body mass (VT:0001259)body weight (CMO:0000012)1151162512256448636Rat
1354646Kidm18Kidney mass QTL 185.7kidney mass (VT:0002707)calculated kidney weight (CMO:0000160)1151162512256448636Rat
1354661Bw33Body weight QTL 335.2body mass (VT:0001259)body weight (CMO:0000012)1151162512256448636Rat
1358886Bp260Blood pressure QTL 2603.67arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)1151162766225824951Rat
61343Bp28Blood pressure QTL 28arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1151646613196646613Rat
1549837Hcar15Hepatocarcinoma resistance QTL 150.05liver integrity trait (VT:0010547)liver tumorous lesion number (CMO:0001068)1153136852260522016Rat
2303622Vencon6Ventilatory control QTL 60.001respiration trait (VT:0001943)respiration rate (CMO:0000289)1154561505199561505Rat
4889428Stresp24Stress response QTL 240.05heart pumping trait (VT:2000009)absolute change in electrocardiographic low frequency R-R spectral component to high frequency R-R spectral component ratio (CMO:0002162)1155866514200866514Rat
1354618Kidm15Kidney mass QTL 155kidney mass (VT:0002707)left kidney wet weight (CMO:0000083)1156677124201278233Rat
2312420Pur17Proteinuria QTL 177.10.0001urine protein amount (VT:0005160)urine total protein excretion rate (CMO:0000756)1156677124218753816Rat
1354580Scort1Serum corticosterone level QTL 13.4blood corticosterone amount (VT:0005345)blood corticosterone level (CMO:0001172)1156677124256448636Rat
61347Bp197Blood pressure QTL 1974.2arterial blood pressure trait (VT:2000000)blood pressure measurement (CMO:0000003)1158633083203633083Rat
2292222Bp307Blood pressure QTL 3073.060.0014arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1164310393213533942Rat
2292220Bp306Blood pressure QTL 3063.470.00087arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1164310393243914901Rat
619613Bp77Blood pressure QTL 770.01arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1164747424209747424Rat
619613Bp77Blood pressure QTL 770.01arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)1164747424209747424Rat
2312558Glom17Glomerulus QTL 173.90.001kidney glomerulus morphology trait (VT:0005325)index of glomerular damage (CMO:0001135)1166532971191278129Rat
1354653Despr9Despair related QTL 90.00019locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)1167909849212909849Rat
619614Bp78Blood pressure QTL 780.001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1169112897197261052Rat
619614Bp78Blood pressure QTL 780.001arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)1169112897197261052Rat
61341Bp26Blood pressure QTL 26arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1169537671214537671Rat
724562Rends1Renal damage susceptibility QTL 10.05kidney glomerulus integrity trait (VT:0010546)index of glomerular damage (CMO:0001135)1169537671214537671Rat
1358294Bw37Body weight QTL 3750.000011body mass (VT:0001259)body weight (CMO:0000012)1171310381216310381Rat
2293689Bss47Bone structure and strength QTL 477.250.0001lumbar vertebra size trait (VT:0010518)lumbar vertebra trabecular cross-sectional area (CMO:0001692)1171629477216629477Rat
2293693Bss22Bone structure and strength QTL 2233.520.0001femur morphology trait (VT:0000559)femur cross-sectional area (CMO:0001661)1171629477216629477Rat
2300161Bmd43Bone mineral density QTL 438.40.0001femur mineral mass (VT:0010011)volumetric bone mineral density (CMO:0001553)1171629477216629477Rat
2300174Bmd42Bone mineral density QTL 428.40.0001lumbar vertebra mineral mass (VT:0010511)bone mineral density (CMO:0001226)1171629477216629477Rat
2300187Bmd41Bone mineral density QTL 418.90.0001femur mineral mass (VT:0010011)volumetric bone mineral density (CMO:0001553)1171629477216629477Rat
2293654Bss30Bone structure and strength QTL 3032.650.0001femur strength trait (VT:0010010)femur midshaft polar moment of inertia (CMO:0001669)1171629477216629477Rat
2293673Bss27Bone structure and strength QTL 2718.630.0001femur morphology trait (VT:0000559)femur midshaft cortical cross-sectional area (CMO:0001663)1171629477216629477Rat
2293677Bss41Bone structure and strength QTL 419.380.0001lumbar vertebra size trait (VT:0010518)lumbar vertebra cross-sectional area (CMO:0001689)1171629477216629477Rat
1549830Bss1Bone structure and strength QTL 14.8femur strength trait (VT:0010010)femur ultimate force (CMO:0001675)1172609619217609619Rat
61326Eae6Experimental allergic encephalomyelitis QTL 65.3body mass (VT:0001259)change in body weight (CMO:0002045)1172949660181830018Rat
631214Bw61Body weight QTL613.40.0001intramuscular adipose amount (VT:0010044)intramuscular fat area (CMO:0001162)1173108781218108781Rat
631670Iddm10Insulin dependent diabetes mellitus QTL 101.9blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)1174133260196383635Rat
70163Bw20Body weight QTL 205.1body mass (VT:0001259)body weight (CMO:0000012)1174133260219133260Rat
738032Hcas5Hepatocarcinoma susceptibility QTL 53.12liver integrity trait (VT:0010547)liver tumorous lesion number (CMO:0001068)1176426412257976495Rat
1600380Niddm70Non-insulin dependent diabetes mellitus QTL 703.10.0008blood insulin amount (VT:0001560)plasma insulin level (CMO:0000342)1176550523221550523Rat
10059600Bp378Blood pressure QTL 3783.080.05arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1176869060221869060Rat
1354624Cm35Cardiac mass QTL355.7heart left ventricle mass (VT:0007031)calculated heart weight (CMO:0000073)1177227632256448636Rat
1354652Kidm20Kidney mass QTL 204.3kidney mass (VT:0002707)calculated kidney weight (CMO:0000160)1177227632256448636Rat
1558658Bw59Body weight QTL 593.50.0003body mass (VT:0001259)body weight (CMO:0000012)1178784622223784622Rat
2325725Eae31Experimental allergic encephalomyelitis QTL 31nervous system integrity trait (VT:0010566)experimental autoimmune encephalomyelitis severity score (CMO:0001419)1178810256188377506Rat
634321Hc1Hypercalciuria QTL 12.91urine calcium amount (VT:0002985)urine calcium excretion rate (CMO:0000763)1178810256240830002Rat
1578763Kidm29Kidney mass QTL 293.30.0001kidney mass (VT:0002707)both kidneys wet weight (CMO:0000085)1179567751260522016Rat
1302787Stl25Serum triglyceride level QTL 252.70.0073blood triglyceride amount (VT:0002644)plasma triglyceride level (CMO:0000548)1180359209210702199Rat
6903303Scl34Serum cholesterol QTL 342.50.0033blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)1180359209218108781Rat
737977Bp160Blood pressure QTL 1600.001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)1181133855226133855Rat
61378Bp43Blood pressure QTL 4322.6arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1181746937196383635Rat
724559Pancm1Pancreatic morphology QTL 17.1islet of Langerhans morphology trait (VT:0005215)pancreatic islet damage composite score (CMO:0001156)1181759564214537555Rat

Markers in Region
D12Wox9  
Rat AssemblyChrPosition (strand)SourceJBrowse
Rnor_5.01220,239,829 - 20,239,932NCBIRnor5.0
Rnor_5.01205,564,366 - 205,564,501NCBIRnor5.0
Rnor_5.01220,239,828 - 20,239,932NCBIRnor5.0
Rnor_5.01205,564,367 - 205,564,501NCBIRnor5.0
RGSC_v3.41186,388,833 - 186,388,966UniSTSRGSC3.4
RGSC_v3.41216,601,685 - 16,601,788RGDRGSC3.4
RGSC_v3.41186,388,832 - 186,388,966RGDRGSC3.4
RGSC_v3.41216,601,686 - 16,601,788UniSTSRGSC3.4
RGSC_v3.11186,538,713 - 186,538,847RGD
Celera1217,843,923 - 17,844,025UniSTS
Celera1179,400,694 - 179,400,827UniSTS
RH 3.4 Map12241.0UniSTS
Cytogenetic Map1q36UniSTS
D1Wox20  
Rat AssemblyChrPosition (strand)SourceJBrowse
Rnor_5.01205,563,901 - 205,567,387NCBIRnor5.0
RGSC_v3.41186,388,367 - 186,391,852RGDRGSC3.4
RH 3.4 Map12241.0RGD
RH 2.0 Map12172.1RGD


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 2 28 20 19 20 1 1 9
Low 1 43 29 21 21 8 9 34 34 38 2 8
Below cutoff 2 40 2

Sequence


Reference Sequences
RefSeq Acc Id: ENSRNOT00000055013   ⟹   ENSRNOP00000051894
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1181,746,429 - 181,759,628 (-)Ensembl
Rnor_6.0 Ensembl1198,572,999 - 198,577,226 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000100623   ⟹   ENSRNOP00000081397
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1181,746,429 - 181,751,629 (-)Ensembl
RefSeq Acc Id: NM_001271086   ⟹   NP_001258015
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21181,746,937 - 181,751,164 (-)NCBI
Rnor_6.01198,572,999 - 198,577,226 (-)NCBI
Rnor_5.01205,563,659 - 205,576,290 (-)NCBI
Celera1179,399,985 - 179,404,212 (-)NCBI
Sequence:
RefSeq Acc Id: XM_006230213   ⟹   XP_006230275
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21181,747,180 - 181,759,564 (-)NCBI
Rnor_6.01198,573,000 - 198,585,664 (-)NCBI
Rnor_5.01205,563,659 - 205,576,290 (-)NCBI
Sequence:
RefSeq Acc Id: XM_008759858   ⟹   XP_008758080
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21181,747,180 - 181,751,166 (-)NCBI
Rnor_6.01198,573,000 - 198,577,792 (-)NCBI
Sequence:
RefSeq Acc Id: XM_039100858   ⟹   XP_038956786
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21181,747,180 - 181,759,564 (-)NCBI
Reference Sequences
RefSeq Acc Id: NP_001258015   ⟸   NM_001271086
- Peptide Label: precursor
- UniProtKB: R9PXZ7 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006230275   ⟸   XM_006230213
- Peptide Label: isoform X1
- UniProtKB: R9PXZ7 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_008758080   ⟸   XM_008759858
- Peptide Label: isoform X1
- UniProtKB: R9PXZ7 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSRNOP00000051894   ⟸   ENSRNOT00000055013
RefSeq Acc Id: XP_038956786   ⟸   XM_039100858
- Peptide Label: isoform X1
- UniProtKB: R9PXZ7 (UniProtKB/TrEMBL)
RefSeq Acc Id: ENSRNOP00000081397   ⟸   ENSRNOT00000100623

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P13838-F1-model_v2 AlphaFold P13838 1-378 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13690426
Promoter ID:EPDNEW_R950
Type:single initiation site
Name:Spn_1
Description:sialophorin
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.01198,577,226 - 198,577,286EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:3750 AgrOrtholog
BioCyc Gene G2FUF-57387 BioCyc
Ensembl Genes ENSRNOG00000036711 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Protein ENSRNOP00000051894 ENTREZGENE
  ENSRNOP00000051894.4 UniProtKB/TrEMBL
  ENSRNOP00000081397 ENTREZGENE
  ENSRNOP00000081397.1 UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000055013 ENTREZGENE
  ENSRNOT00000055013.5 UniProtKB/TrEMBL
  ENSRNOT00000100623 ENTREZGENE
  ENSRNOT00000100623.1 UniProtKB/TrEMBL
InterPro Leukosialin UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:24796 UniProtKB/TrEMBL
NCBI Gene 24796 ENTREZGENE
PANTHER LEUKOSIALIN UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PTHR35265 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Spn PhenoGen
TIGR TC207090
UniProt LEUK_RAT UniProtKB/Swiss-Prot, ENTREZGENE
  R9PXZ7 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2003-04-09 Spn  sialophorin      Name updated 629478 APPROVED
2003-03-07 Spn  sialophorin  Lsn  Leukosialin  Data Merged 628472 PROVISIONAL
2003-03-07   sialophorin  Spn  Sialophorin (gpL115, leukosianin, CD43)  Symbol and Name updated to reflect Human and Mouse nomenclature 61478 PENDING
2002-06-10 Spn  Sialophorin (gpL115, leukosianin, CD43)      Symbol and Name status set to approved 70586 APPROVED
2002-06-10 Lsn  Leukosialin      Symbol and Name status set to approved 70586 APPROVED

RGD Curation Notes
Note Type Note Reference
gene_product a third of the extracellular amino acids may be O-glycosylated 729976
gene_protein 371 amino acids 729976