Spink1 (serine peptidase inhibitor, Kazal type 1) - Rat Genome Database

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Gene: Spink1 (serine peptidase inhibitor, Kazal type 1) Rattus norvegicus
Analyze
Symbol: Spink1
Name: serine peptidase inhibitor, Kazal type 1
RGD ID: 3749
Description: Enables serine-type endopeptidase inhibitor activity. Involved in several processes, including cellular response to peptide hormone stimulus; positive regulation of secretion; and response to ethanol. Located in extracellular space. Human ortholog(s) of this gene implicated in pancreatitis. Orthologous to human SPINK1 (serine peptidase inhibitor Kazal type 1); INTERACTS WITH 1,1-dichloroethene; 1,2-dimethylhydrazine; 1-nitropropane.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: cholecystokinin-releasing peptide; monitor peptide; pancreatic cholecystokinin(CCK) releasing peptide; pancreatic secretory trypsin inhibitor; pancreatic secretory trypsin inhibitor I; pancreatic secretory trypsin inhibitor-61; Psti-1; PSTI-61; PSTI-I; serine peptidase inhibitor, Kazal type 3; Serine protease inhibitor kanzal type 1/ Trypsin inhibitor-like protein pancreatic; serine protease inhibitor Kazal-type 1; Serine protease inhibitor, kanzal type 1/ Trypsin inhibitor-like protein, pancreatic; serine protease inhibitor, Kazal type 1; Spink3; Tilp; trypsin inhibitor-like protein, pancreatic
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Is Marker For: QTLs:   Bw11  
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81836,121,626 - 36,133,596 (-)NCBIGRCr8
mRatBN7.21835,870,723 - 35,882,693 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1835,824,550 - 35,882,642 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1835,974,739 - 35,986,709 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01836,693,067 - 36,705,037 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01836,070,012 - 36,081,982 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01838,221,919 - 38,242,092 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1838,221,681 - 38,242,119 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01837,878,841 - 37,898,259 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41837,135,503 - 37,148,282 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Cytogenetic Map18q11NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
1,1-dichloroethene  (EXP)
1,2-dichloroethane  (ISO)
1,2-dimethylhydrazine  (EXP,ISO)
1-nitropropane  (EXP)
17alpha-ethynylestradiol  (EXP)
17beta-estradiol  (EXP,ISO)
2,2',4,4'-Tetrabromodiphenyl ether  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,4-diaminotoluene  (EXP)
2,6-diaminotoluene  (EXP)
2-acetamidofluorene  (EXP)
2-hydroxypropanoic acid  (ISO)
2-nitro-p-phenylenediamine  (EXP)
2-nitropropane  (EXP)
3H-1,2-dithiole-3-thione  (EXP)
4,4'-diaminodiphenylmethane  (ISO)
4,4'-sulfonyldiphenol  (ISO)
4-acetylaminofluorene  (EXP)
4-nitro-1,2-phenylenediamine  (EXP)
9-cis-retinoic acid  (EXP)
aflatoxin B1  (ISO)
ammonium chloride  (EXP)
Archazolid B  (ISO)
arsane  (ISO)
arsenic atom  (ISO)
azathioprine  (EXP,ISO)
bazedoxifene  (ISO)
benzo[a]pyrene  (ISO)
benzo[b]fluoranthene  (ISO)
Benzo[k]fluoranthene  (ISO)
beta-naphthoflavone  (EXP)
bexarotene  (EXP)
bis(2-chloroethyl) sulfide  (ISO)
bis(2-ethylhexyl) phthalate  (ISO)
bisphenol A  (EXP,ISO)
bisphenol F  (ISO)
buspirone  (EXP)
buta-1,3-diene  (ISO)
butanal  (ISO)
cadmium atom  (ISO)
cadmium dichloride  (EXP,ISO)
carbon nanotube  (ISO)
cefaloridine  (EXP)
chrysene  (ISO)
ciguatoxin CTX1B  (ISO)
copper atom  (ISO)
copper(0)  (ISO)
copper(II) sulfate  (ISO)
crocidolite asbestos  (ISO)
cyclosporin A  (ISO)
cytarabine  (ISO)
decabromodiphenyl ether  (EXP)
dichromium trioxide  (ISO)
dicrotophos  (ISO)
dioxygen  (ISO)
diquat  (ISO)
dorsomorphin  (ISO)
erythromycin estolate  (EXP)
ethanol  (EXP)
fentin chloride  (EXP)
fipronil  (EXP)
flavonoids  (EXP)
flutamide  (EXP)
folic acid  (ISO)
furan  (EXP)
furosemide  (EXP)
glafenine  (EXP)
hydroquinone  (ISO)
indole-3-methanol  (EXP)
inulin  (ISO)
lasofoxifene  (ISO)
lead diacetate  (ISO)
lipopolysaccharide  (ISO)
menadione  (ISO)
mercury atom  (EXP)
mercury(0)  (EXP)
methapyrilene  (EXP)
N-methyl-N'-nitro-N-nitrosoguanidine  (ISO)
N-nitrosodiethylamine  (EXP,ISO)
nefazodone  (EXP)
nickel atom  (ISO)
nimesulide  (EXP)
panobinostat  (ISO)
paracetamol  (ISO)
perfluorooctane-1-sulfonic acid  (EXP,ISO)
perfluorooctanoic acid  (EXP)
phenacetin  (EXP)
phenformin  (EXP)
phenobarbital  (ISO)
phenylhydrazine  (EXP)
phenylmercury acetate  (ISO)
pirinixic acid  (ISO)
pregnenolone 16alpha-carbonitrile  (EXP)
progesterone  (ISO)
quercetin  (ISO)
rac-lactic acid  (ISO)
raloxifene  (ISO)
rotenone  (EXP)
SB 431542  (ISO)
silicon dioxide  (ISO)
sodium arsenate  (ISO)
sodium arsenite  (ISO)
sodium dichromate  (EXP)
tamoxifen  (EXP)
testosterone  (ISO)
tetrachloromethane  (EXP,ISO)
thioacetamide  (EXP)
titanium dioxide  (ISO)
tributylstannane  (ISO)
trichloroethene  (EXP)
trichostatin A  (ISO)
triphenyl phosphate  (EXP)
valdecoxib  (EXP)
valproic acid  (EXP,ISO)
zinc atom  (EXP,ISO)
zinc dichloride  (ISO)
zinc(0)  (EXP,ISO)
zoledronic acid  (ISO)

References

References - curated
# Reference Title Reference Citation
1. CFTR, PRSS1 and SPINK1 mutations in the development of pancreatitis in Brazilian patients. Bernardino AL, etal., JOP 2003 Sep;4(5):169-77.
2. Monitor peptide (rat pancreatic secretory trypsin inhibitor) directly stimulates the proliferation of the nontransformed intestinal epithelial cell line, IEC-6. Fukuda M, etal., Digestion. 1998 Jul-Aug;59(4):326-30.
3. Rapid and selective cloning of monitor peptide, a novel cholecystokinin-releasing peptide, using minimal amino acid sequence and the polymerase chain reaction. Fukuoka S and Scheele GA, Pancreas 1990;5(1):1-7.
4. Complementary nucleotide sequence for monitor peptide, a novel cholecystokinin-releasing peptide in the rat. Fukuoka SI and Scheele G, Nucleic Acids Res 1989 Dec 11;17(23):10111.
5. The Bifunctional Rat Pancreatic Secretory Trypsin Inhibitor/Monitor Peptide Provides Protection against Premature Activation of Pancreatic Juice. Graf R, etal., Pancreatology 2003;3(3):195-206.
6. Increased secretion of the pancreatic secretory trypsin inhibitor (PSTI-I, monitor peptide) during development of chronic pancreatitis in the WBN/Kob rat. Graf R, etal., Pancreatology. 2002;2(2):108-15.
7. On the cDNA's for two types of rat pancreatic secretory trypsin inhibitor. Horii A, etal., Biochem Biophys Res Commun 1989 Jul 14;162(1):151-9.
8. Differential expression of trypsinogen and tumor-associated trypsin inhibitor (TATI) in bladder cancer. Hotakainen K, etal., Int J Oncol. 2006 Jan;28(1):95-101.
9. Tumor markers CA 125, carcinoembryonic antigen and tumor-associated trypsin inhibitor in patients with cervical adenocarcinoma. Leminen A Gynecol Oncol. 1990 Dec;39(3):358-63.
10. Chronic ethanol consumption induces gene expression of pancreatic monitor peptide, but not SPINK1/PSTI-56, in rats. Li HS, etal., Pancreas. 2001 Aug;23(2):117-24.
11. Cholecystokinin cells purified by fluorescence-activated cell sorting respond to monitor peptide with an increase in intracellular calcium. Liddle RA, etal., Proc Natl Acad Sci U S A. 1992 Jun 1;89(11):5147-51.
12. Tumor-associated trypsin inhibitor in normal and malignant renal tissue and in serum of renal-cell carcinoma patients. Lukkonen A, etal., Int J Cancer. 1999 Nov 12;83(4):486-90.
13. Serum levels of the tumour-associated trypsin inhibitor in patients with endometriosis. Medl M, etal., Br J Obstet Gynaecol. 1997 Jan;104(1):78-81.
14. Stimulatory effect of monitor peptide and human pancreatic secretory trypsin inhibitor on pancreatic secretion and cholecystokinin release in conscious rats. Miyasaka K, etal., Pancreas. 1989;4(2):139-44.
15. Transgenic expression of pancreatic secretory trypsin inhibitor-I ameliorates secretagogue-induced pancreatitis in mice. Nathan JD, etal., Gastroenterology. 2005 Mar;128(3):717-27.
16. Protection against chronic pancreatitis and pancreatic fibrosis in mice overexpressing pancreatic secretory trypsin inhibitor. Nathan JD, etal., Pancreas. 2010 Jan;39(1):e24-30. doi: 10.1097/MPA.0b013e3181bc45e9.
17. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
18. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
19. Expression of trypsinogen-1, trypsinogen-2, and tumor-associated trypsin inhibitor in ovarian cancer: prognostic study on tissue and serum. Paju A, etal., Clin Cancer Res. 2004 Jul 15;10(14):4761-8.
20. Increased expression of tumor-associated trypsin inhibitor, TATI, in prostate cancer and in androgen-independent 22Rv1 cells. Paju A, etal., Eur Urol. 2007 Dec;52(6):1670-9. Epub 2007 Feb 5.
21. Tumor associated trypsin inhibitor as a prognostic factor in renal cell carcinoma. Paju A, etal., J Urol. 2001 Mar;165(3):959-62.
22. TATI (tumor associated trypsin inhibitor) and cancer antigen 125 (CA 125) in patients with early-stage endometrial cancer. Peters-Engl C, etal., Anticancer Res. 1998 Nov-Dec;18(6B):4635-9.
23. GOA pipeline RGD automated data pipeline
24. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
25. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
26. Pancreatic secretory trypsin inhibitor I reduces the severity of chronic pancreatitis in mice overexpressing interleukin-1beta in the pancreas. Romac JM, etal., Am J Physiol Gastrointest Liver Physiol. 2012 Mar 1;302(5):G535-41. doi: 10.1152/ajpgi.00287.2011. Epub 2011 Dec 15.
27. Urinary levels of tumor-associated trypsin inhibitor (TATI) in the detection of transitional cell carcinoma of the urinary bladder. Shariat SF, etal., Eur Urol. 2005 Sep;48(3):424-31.
28. Effect of a high-protein diet on the gene expression of a trypsin-sensitive, cholecystokinin-releasing peptide (monitor peptide) in the pancreas. Tsuzuki S, etal., Eur J Biochem 1991 Jul 1;199(1):245-52.
29. Monitor peptide gene expression is increased by exogenous CCK in the rat pancreas and in a rat pancreatic acinar cell line (AR4-2J). Tsuzuki S, etal., FEBS Lett. 1992 Aug 3;307(3):386-8.
30. Elevation of circulating monitor peptide/pancreatic secretory trypsin inhibitor-I (PSTI-61) after turpentine-induced inflammation in rats: hepatocytes produce it as an acute phase reactant. Uda K, etal., J Surg Res. 1994 Nov;57(5):563-8.
31. Mutations in the gene encoding the serine protease inhibitor, Kazal type 1 are associated with chronic pancreatitis. Witt H, etal., Nat Genet. 2000 Jun;25(2):213-6.
Additional References at PubMed
PMID:1390891   PMID:2430282   PMID:3202973   PMID:3428272   PMID:3597401   PMID:18054043   PMID:18550793   PMID:18715980   PMID:20110462   PMID:21734281   PMID:22206666   PMID:22228629  
PMID:23533145   PMID:27414783  


Genomics

Comparative Map Data
Spink1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81836,121,626 - 36,133,596 (-)NCBIGRCr8
mRatBN7.21835,870,723 - 35,882,693 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1835,824,550 - 35,882,642 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1835,974,739 - 35,986,709 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01836,693,067 - 36,705,037 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01836,070,012 - 36,081,982 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01838,221,919 - 38,242,092 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1838,221,681 - 38,242,119 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01837,878,841 - 37,898,259 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41837,135,503 - 37,148,282 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Cytogenetic Map18q11NCBI
SPINK1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh385147,824,582 - 147,839,196 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl5147,824,572 - 147,831,671 (-)EnsemblGRCh38hg38GRCh38
GRCh375147,204,145 - 147,218,759 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 365147,184,339 - 147,191,453 (-)NCBINCBI36Build 36hg18NCBI36
Build 345147,184,338 - 147,191,453NCBI
Celera5143,286,018 - 143,293,135 (-)NCBICelera
Cytogenetic Map5q32NCBI
HuRef5142,351,294 - 142,358,402 (-)NCBIHuRef
CHM1_15146,636,518 - 146,643,635 (-)NCBICHM1_1
T2T-CHM13v2.05148,360,276 - 148,374,975 (-)NCBIT2T-CHM13v2.0
Spink1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391843,861,134 - 43,870,302 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1843,861,147 - 43,870,622 (-)EnsemblGRCm39 Ensembl
GRCm381843,728,069 - 43,737,237 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1843,728,082 - 43,737,557 (-)EnsemblGRCm38mm10GRCm38
MGSCv371843,887,723 - 43,896,891 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361843,853,416 - 43,862,528 (-)NCBIMGSCv36mm8
Celera1845,096,166 - 45,111,565 (-)NCBICelera
Cytogenetic Map18B3NCBI
cM Map1823.47NCBI
Spink1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554156,371,059 - 6,378,529 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049554156,328,672 - 6,378,611 (+)NCBIChiLan1.0ChiLan1.0
SPINK1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v24143,077,196 - 143,091,804 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan15141,216,747 - 141,231,379 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v05143,273,137 - 143,287,745 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.15149,282,828 - 149,297,469 (-)NCBIpanpan1.1PanPan1.1panPan2
SPINK1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1242,112,015 - 42,120,738 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl242,112,016 - 42,120,706 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha239,152,835 - 39,161,514 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0242,566,457 - 42,575,135 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl242,566,457 - 42,575,107 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1239,642,905 - 39,651,567 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0240,452,599 - 40,461,319 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0241,275,547 - 41,284,243 (-)NCBIUU_Cfam_GSD_1.0
Spink1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024407213145,400,956 - 145,407,408 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365046,975,044 - 6,981,304 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049365046,975,044 - 6,981,304 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
SPINK1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl2149,071,703 - 149,079,499 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.12149,072,652 - 149,079,529 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.22155,635,045 - 155,641,908 (-)NCBISscrofa10.2Sscrofa10.2susScr3
SPINK1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12350,365,686 - 50,373,300 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2350,365,269 - 50,372,814 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366603427,392,009 - 27,396,127 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Spink1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247747,281,227 - 7,287,791 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046247747,281,298 - 7,287,735 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Spink1
62 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:67
Count of miRNA genes:61
Interacting mature miRNAs:62
Transcripts:ENSRNOT00000017969, ENSRNOT00000018110
Prediction methods:Microtar, Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
9589153Insul31Insulin level QTL 317.150.05blood insulin amount (VT:0001560)plasma insulin level (CMO:0000342)18142547119Rat
2299160Iddm35Insulin dependent diabetes mellitus QTL 352.79blood glucose amount (VT:0000188)age at onset/diagnosis of type 1 diabetes mellitus (CMO:0001140)18420794160377792Rat
2312568Glom21Glomerulus QTL 2120.005kidney glomerulus morphology trait (VT:0005325)index of glomerular damage (CMO:0001135)18518585840503530Rat
2293708Bss46Bone structure and strength QTL 468.80.0001lumbar vertebra morphology trait (VT:0010494)lumbar vertebra cortical cross-sectional area (CMO:0001690)181179151863636873Rat
1578661Bss20Bone structure and strength QTL 203.7femur morphology trait (VT:0000559)femoral neck cross-sectional area (CMO:0001697)181179151883218561Rat
1578667Bss21Bone structure and strength QTL 213.5femur morphology trait (VT:0000559)femoral neck cortical cross-sectional area (CMO:0001702)181179151883218561Rat
61375Bp41Blood pressure QTL 412.4blood pressure trait (VT:0000183)systolic blood pressure (CMO:0000004)181194429941122201Rat
1331753Bp231Blood pressure QTL 2313.643arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)181194429952293055Rat
1358358Sradr6Stress Responsive Adrenal Weight QTL 62.49adrenal gland mass (VT:0010420)both adrenal glands wet weight (CMO:0000164)181194429959330563Rat
6903359Bp355Blood pressure QTL 3553.6arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)181194454459796478Rat
2313082Bss85Bone structure and strength QTL 850.80.0001long bone metaphysis morphology trait (VT:0000133)tibia midshaft total cross-sectional area (CMO:0001715)181495133759951337Rat
1358193Emca2Estrogen-induced mammary cancer QTL 21.6mammary gland integrity trait (VT:0010552)post-insult time to mammary tumor formation (CMO:0000345)181800759963571040Rat
1600373Mamtr6Mammary tumor resistance QTL 6mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)181927890183218561Rat
1331741Bp232Blood pressure QTL 2323.59112arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)182137289383213037Rat
1641923Colcr8Colorectal carcinoma resistance QTL 83.10.0014intestine integrity trait (VT:0010554)poorly differentiated malignant colorectal tumor number (CMO:0002076)182206624252293055Rat
1331733Bp233Blood pressure QTL 2333.97196arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)182479697779788953Rat
2325839Bp348Blood pressure QTL 3480.001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)182557098570570985Rat
12904673Cm127Cardiac mass QTL 1270.005heart right ventricle mass (VT:0007033)heart right ventricle weight to body weight ratio (CMO:0000914)182654808246969551Rat
12904675Am19Aortic mass QTL 190.001aorta mass (VT:0002845)aorta weight to aorta length to body weight ratio (CMO:0002722)182654808246969551Rat
12904677Kidm72Kidney mass QTL 720.001kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)182654808246969551Rat
12904668Bw188Body weight QTL 1880.03body mass (VT:0001259)body weight (CMO:0000012)182654808246969551Rat
12904669Cm125Cardiac mass QTL 1250.001heart mass (VT:0007028)heart wet weight to body weight ratio (CMO:0002408)182654808246969551Rat
12904670Cm126Cardiac mass QTL 1260.001heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)182654808246969551Rat
2301413Bp318Blood pressure QTL 3180.002arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)182654808246969551Rat
2293704Bss35Bone structure and strength QTL 354.590.0002femur strength trait (VT:0010010)femur midshaft polar moment of inertia (CMO:0001669)182896485373964853Rat
2300157Bmd66Bone mineral density QTL 6613.10.0001lumbar vertebra mineral mass (VT:0010511)volumetric bone mineral density (CMO:0001553)182896485373964853Rat
2300177Bmd65Bone mineral density QTL 6519.70.0001femur mineral mass (VT:0010011)volumetric bone mineral density (CMO:0001553)182896485373964853Rat
9589816Gluco68Glucose level QTL 687.250.001blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)182979296574792965Rat
8694378Bw157Body weight QTL 1573.590.001body lean mass (VT:0010483)lean tissue morphological measurement (CMO:0002184)182979296574792965Rat
9590318Scort22Serum corticosterone level QTL 227.640.001blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)182979296574792965Rat
1331754Bp230Blood pressure QTL 2304.61609arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)182979296574792965Rat
738005Anxrr11Anxiety related response QTL 113.4exploratory behavior trait (VT:0010471)number of entries into a discrete space in an experimental apparatus (CMO:0000960)183003981375039813Rat
61383Bp47Blood pressure QTL 4717.3arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)183127168160377755Rat
1331742Bp228Blood pressure QTL 2283.88752arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)183135940859796643Rat
1331774Bp226Blood pressure QTL 2264.41065arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)183135940859796643Rat
1331776Bp225Blood pressure QTL 2252.829arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)183135940859796643Rat
1331798Bp224Blood pressure QTL 2243.53873arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)183135940859796643Rat
1331727Bp237Blood pressure QTL 2373.053arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)183135940861698465Rat
61429Cia17Collagen induced arthritis QTL 174.6joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)183135940870263868Rat
2303120Mamtr8Mammary tumor resistance QTL 80.001mammary gland integrity trait (VT:0010552)mammary tumor growth rate (CMO:0000344)183135940883218561Rat
6903347Bp350Blood pressure QTL 3504.4arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)183135953059796478Rat
631274Sprol1Serum protein level QTL 15.3blood total protein amount (VT:0005567)serum total protein level (CMO:0000661)183139332077209694Rat
631518Bw11Body weight QTL 112.8body mass (VT:0001259)body weight (CMO:0000012)183587072380870723Rat

Markers in Region
D18Wox9  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21835,869,420 - 35,869,662 (+)MAPPERmRatBN7.2
Rnor_6.01838,220,617 - 38,220,858NCBIRnor6.0
Rnor_6.01838,176,135 - 38,176,377NCBIRnor6.0
Rnor_5.01837,833,057 - 37,833,299UniSTSRnor5.0
Rnor_5.01837,877,539 - 37,877,780UniSTSRnor5.0
RGSC_v3.41837,134,200 - 37,134,442RGDRGSC3.4
RGSC_v3.41837,134,201 - 37,134,442UniSTSRGSC3.4
Cytogenetic Map18pUniSTS
D18Arb2  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21835,869,194 - 35,869,762 (+)MAPPERmRatBN7.2
Rnor_6.01838,175,909 - 38,176,477NCBIRnor6.0
Rnor_6.01838,220,391 - 38,220,958NCBIRnor6.0
Rnor_5.01837,877,313 - 37,877,880UniSTSRnor5.0
Rnor_5.01837,832,831 - 37,833,399UniSTSRnor5.0
RGSC_v3.41837,133,975 - 37,134,542UniSTSRGSC3.4
Cytogenetic Map18pUniSTS


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system nervous system renal system reproductive system respiratory system
High
Medium 2 8 8 4 8 9
Low 1 16 15 5 15 14
Below cutoff 16 4 2 2 1 2 5 6

Sequence


RefSeq Acc Id: ENSRNOT00000018110   ⟹   ENSRNOP00000018110
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl1838,221,681 - 38,242,119 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000095851   ⟹   ENSRNOP00000095930
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1835,824,550 - 35,882,642 (-)Ensembl
RefSeq Acc Id: NM_012674   ⟹   NP_036806
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81836,121,626 - 36,133,596 (-)NCBI
mRatBN7.21835,870,723 - 35,882,693 (-)NCBI
Rnor_6.01838,221,919 - 38,242,092 (-)NCBI
Rnor_5.01837,878,841 - 37,898,259 (-)NCBI
RGSC_v3.41837,135,503 - 37,148,282 (-)RGD
Sequence:
RefSeq Acc Id: NP_036806   ⟸   NM_012674
- Peptide Label: precursor
- UniProtKB: P13072 (UniProtKB/Swiss-Prot),   P09655 (UniProtKB/Swiss-Prot),   A6KUD5 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSRNOP00000018110   ⟸   ENSRNOT00000018110
RefSeq Acc Id: ENSRNOP00000095930   ⟸   ENSRNOT00000095851
Protein Domains
Kazal-like

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P09655-F1-model_v2 AlphaFold P09655 1-79 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13700755
Promoter ID:EPDNEW_R11279
Type:multiple initiation site
Name:Spink1_1
Description:serine peptidase inhibitor, Kazal type 1
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.01838,242,109 - 38,242,169EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:3749 AgrOrtholog
BioCyc Gene G2FUF-7677 BioCyc
Ensembl Genes ENSRNOG00000013464 Ensembl
  ENSRNOG00000068869 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
  ENSRNOG00055018811 UniProtKB/Swiss-Prot
  ENSRNOG00060011889 UniProtKB/Swiss-Prot
  ENSRNOG00065019301 UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000095851 ENTREZGENE
  ENSRNOT00000095851.1 UniProtKB/Swiss-Prot
  ENSRNOT00055032064 UniProtKB/Swiss-Prot
  ENSRNOT00060020113 UniProtKB/Swiss-Prot
  ENSRNOT00065032483 UniProtKB/Swiss-Prot
Gene3D-CATH 3.30.60.30 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro Kazal_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Kazal_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:24833 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
NCBI Gene 24833 ENTREZGENE
PANTHER SERINE PROTEASE INHIBITOR UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SERINE PROTEASE INHIBITOR KAZAL-TYPE 1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam Kazal_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Spink1 PhenoGen
PROSITE KAZAL_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  KAZAL_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
RatGTEx ENSRNOG00000013464 RatGTEx
  ENSRNOG00000068869 RatGTEx
  ENSRNOG00055018811 RatGTEx
  ENSRNOG00060011889 RatGTEx
  ENSRNOG00065019301 RatGTEx
SMART KAZAL UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP Kazal-type serine protease inhibitors UniProtKB/TrEMBL, UniProtKB/Swiss-Prot
UniProt A6KUD5 ENTREZGENE, UniProtKB/TrEMBL
  ISK1_RAT UniProtKB/Swiss-Prot, ENTREZGENE
  P13072 ENTREZGENE
UniProt Secondary P13072 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2015-05-20 Spink1  serine peptidase inhibitor, Kazal type 1  Spink3  serine peptidase inhibitor, Kazal type 3  Name and Symbol changed 629549 APPROVED
2008-09-16 Psti-1  pancreatic secretory trypsin inhibitor I  Spink1  serine protease inhibitor, Kazal type 1  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-09-16 Spink3  serine peptidase inhibitor, Kazal type 3   Psti-1  pancreatic secretory trypsin inhibitor I  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2003-04-09 Spink1  serine protease inhibitor, Kazal type 1    Serine protease inhibitor, kanzal type 1/ Trypsin inhibitor-like protein, pancreatic  Name updated 629478 APPROVED
2002-06-10 Spink1  Serine protease inhibitor, kanzal type 1/ Trypsin inhibitor-like protein, pancreatic      Symbol and Name status set to approved 70586 APPROVED

RGD Curation Notes
Note Type Note Reference
gene_disease mutations of the human homolog may be a risk factor for chronic pancreatitis 724700