Sp1 (Sp1 transcription factor) - Rat Genome Database

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Gene: Sp1 (Sp1 transcription factor) Rattus norvegicus
Analyze
Symbol: Sp1
Name: Sp1 transcription factor
RGD ID: 3738
Description: Enables RNA polymerase II cis-regulatory region sequence-specific DNA binding activity; histone acetyltransferase binding activity; and transcription coregulator binding activity. Involved in several processes, including cellular response to estrogen stimulus; cellular response to wortmannin; and cellular response to zinc ion starvation. Located in chromatin and nucleus. Part of protein-DNA complex. Orthologous to human SP1 (Sp1 transcription factor); PARTICIPATES IN phosphatidylinositol 3-kinase-Akt signaling pathway; forkhead class A signaling pathway; hypoxia inducible factor pathway; INTERACTS WITH 1,2-dimethylhydrazine; 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine; 2,2',4,4'-Tetrabromodiphenyl ether.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: trans-acting transcription factor 1; transcription factor Sp1
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr87135,419,864 - 135,450,513 (+)NCBIGRCr8
GRCr8 Ensembl7135,420,050 - 135,450,513 (+)EnsemblGRCr8 Ensembl
mRatBN7.27133,541,302 - 133,571,961 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl7133,541,491 - 133,571,961 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx7135,298,300 - 135,327,653 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.07137,527,694 - 137,557,048 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.07137,513,816 - 137,543,172 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.07144,014,173 - 144,044,635 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl7144,014,173 - 144,044,629 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.07141,805,281 - 141,836,504 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.47141,164,180 - 141,194,509 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera7129,968,890 - 129,999,257 (+)NCBICelera
RGSC_v3.17141,240,616 - 141,265,690 (+)NCBI
RH 3.4 Map71062.1RGD
Cytogenetic Map7q36NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-catechin  (ISO)
(-)-demecolcine  (ISO)
(-)-epigallocatechin 3-gallate  (ISO)
(20S)-ginsenoside Rg3  (ISO)
(R)-lipoic acid  (ISO)
(S)-nicotine  (ISO)
1,2-dimethylhydrazine  (EXP)
1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine  (EXP,ISO)
17alpha-ethynylestradiol  (ISO)
17beta-estradiol  (ISO)
2,2',4,4'-Tetrabromodiphenyl ether  (EXP)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2-chloroethanol  (EXP)
2-tert-butylhydroquinone  (ISO)
3-\{1-[3-(dimethylamino)propyl]-1H-indol-3-yl\}-4-(1H-indol-3-yl)-1H-pyrrole-2,5-dione  (EXP,ISO)
3-methylcholanthrene  (EXP)
4,4'-diaminodiphenylmethane  (ISO)
4,4'-sulfonyldiphenol  (ISO)
4-hydroxyphenyl retinamide  (ISO)
4-nonylphenol  (ISO)
4-tert-Octylphenol  (ISO)
5-aza-2'-deoxycytidine  (ISO)
5-azacytidine  (ISO)
5-fluorouracil  (ISO)
6-propyl-2-thiouracil  (EXP)
7,12-dimethyltetraphene  (EXP,ISO)
acetaldehyde  (ISO)
AH23848  (ISO)
aldehydo-D-glucose  (EXP,ISO)
alendronic acid  (ISO)
all-trans-retinoic acid  (ISO)
allethrin  (ISO)
alpha-D-galactose  (EXP)
alpha-naphthoflavone  (EXP)
amitrole  (EXP)
ammonium chloride  (EXP)
anthra[1,9-cd]pyrazol-6(2H)-one  (EXP,ISO)
antirheumatic drug  (ISO)
aristolochic acid A  (ISO)
Aroclor 1254  (EXP)
arsane  (ISO)
arsenic atom  (ISO)
arsenous acid  (ISO)
artesunate  (ISO)
asbestos  (ISO)
asiatic acid  (EXP,ISO)
astaxanthin  (EXP)
bathocuproine disulfonic acid  (ISO)
benzene  (ISO)
benzo[a]pyrene  (ISO)
Benzo[ghi]perylene  (ISO)
biotin  (ISO)
bis(2-ethylhexyl) phthalate  (ISO)
bisphenol A  (EXP,ISO)
butan-1-ol  (ISO)
Butylbenzyl phthalate  (ISO)
cadmium acetate  (ISO)
cadmium atom  (EXP,ISO)
cadmium dichloride  (EXP,ISO)
caffeine  (ISO)
Calcimycin  (ISO)
camptothecin  (ISO)
capsaicin  (ISO)
carbon nanotube  (ISO)
carnosine  (EXP,ISO)
chloroprene  (EXP)
chloroquine  (ISO)
chlorpyrifos  (EXP,ISO)
choline  (ISO)
chromium(6+)  (EXP)
cisplatin  (ISO)
clofarabine  (ISO)
clofibrate  (ISO)
cobalt dichloride  (EXP,ISO)
cocaine  (EXP)
copper atom  (ISO)
copper(0)  (ISO)
copper(II) sulfate  (ISO)
cordycepin  (EXP,ISO)
coumarin  (ISO)
crocidolite asbestos  (ISO)
CU-O LINKAGE  (ISO)
curcumin  (ISO)
cyclosporin A  (ISO)
cypermethrin  (EXP,ISO)
D-glucose  (EXP,ISO)
D-penicillamine  (ISO)
daunorubicin  (ISO)
decabromodiphenyl ether  (EXP)
deoxynivalenol  (ISO)
desferrioxamine B  (ISO)
Diallyltetrasulfane  (EXP)
diarsenic trioxide  (ISO)
diazinon  (ISO)
Dibutyl phosphate  (ISO)
dibutyl phthalate  (ISO)
dieldrin  (ISO)
diethylstilbestrol  (ISO)
dimethyl sulfoxide  (ISO)
dioxygen  (EXP,ISO)
disodium selenite  (EXP,ISO)
doxorubicin  (ISO)
elemental selenium  (EXP,ISO)
enzyme inhibitor  (ISO)
epoxomicin  (ISO)
esculetin  (ISO)
estrogen  (EXP)
ethanol  (ISO)
etoposide  (EXP,ISO)
flutamide  (EXP)
folic acid  (ISO)
FR900359  (ISO)
fulvestrant  (ISO)
galactose  (EXP)
genistein  (ISO)
gentamycin  (EXP)
glucose  (EXP,ISO)
glutathione  (ISO)
glycitein  (ISO)
glyphosate  (ISO)
Goe 6976  (ISO)
homocysteic acid  (ISO)
hydrogen peroxide  (ISO)
hydroquinone  (ISO)
indole-3-methanol  (ISO)
irinotecan  (ISO)
iron atom  (ISO)
iron(0)  (ISO)
isoprenaline  (ISO)
jaceosidin  (ISO)
ketoconazole  (EXP)
L-ascorbic acid  (ISO)
L-methionine  (ISO)
lead diacetate  (ISO)
lead(0)  (ISO)
lead(II) chloride  (ISO)
lipoic acid  (ISO)
lipopolysaccharide  (ISO)
LY294002  (ISO)
manganese atom  (EXP,ISO)
manganese(0)  (EXP,ISO)
mercury dichloride  (EXP)
metformin  (ISO)
methapyrilene  (EXP)
methimazole  (EXP)
methylmercury chloride  (EXP,ISO)
methylparaben  (ISO)
methylseleninic acid  (ISO)
mibolerone  (ISO)
microcystin-LR  (ISO)
mithramycin  (EXP,ISO)
monosodium L-glutamate  (EXP)
morin  (ISO)
N-acetyl-L-cysteine  (EXP,ISO)
N-benzyloxycarbonyl-L-leucyl-L-leucyl-L-leucinal  (ISO)
N-butyl-N-(4-hydroxybutyl)nitrosamine  (ISO)
N-ethylmaleimide  (ISO)
N-methyl-4-phenylpyridinium  (EXP,ISO)
neocuproine  (ISO)
nickel atom  (ISO)
nickel dichloride  (ISO)
nicotine  (ISO)
nimustine  (ISO)
NORCANTHARIDIN  (ISO)
olomoucine  (ISO)
oxaliplatin  (ISO)
ozone  (ISO)
p-tert-Amylphenol  (ISO)
palbociclib  (ISO)
paracetamol  (ISO)
PD 168393  (EXP)
pentachlorophenol  (ISO)
perfluorooctane-1-sulfonic acid  (ISO)
phenobarbital  (EXP,ISO)
phenylephrine  (ISO)
PhIP  (ISO)
phorbol 13-acetate 12-myristate  (ISO)
platycodin D  (ISO)
promegestone  (ISO)
propiconazole  (ISO)
protein kinase inhibitor  (ISO)
pterostilbene  (ISO)
quercetin  (ISO)
quercetin 3-O-beta-D-galactopyranoside  (ISO)
quinacrine  (ISO)
resveratrol  (EXP,ISO)
S-adenosyl-L-homocysteine  (EXP)
S-adenosyl-L-methioninate  (ISO)
S-adenosyl-L-methionine  (ISO)
S-butyl-DL-homocysteine (S,R)-sulfoximine  (ISO)
S-nitrosoglutathione  (ISO)
SB 203580  (ISO)
SCH772984  (EXP)
selenium atom  (EXP,ISO)
silicon dioxide  (ISO)
silver atom  (ISO)
silver(0)  (ISO)
silver(1+) nitrate  (ISO)
simvastatin  (ISO)
sodium arsenite  (EXP,ISO)
sodium chloride  (EXP)
sodium dichromate  (ISO)
T-2 toxin  (ISO)
tamoxifen  (ISO)
temozolomide  (ISO)
terameprocol  (ISO)
tetrachloroethene  (ISO)
tetrathiomolybdate(2-)  (ISO)
thalidomide  (ISO)
thapsigargin  (EXP)
Theaflavin 3,3'-digallate  (ISO)
Tiron  (ISO)
titanium dioxide  (ISO)
tolfenamic acid  (ISO)
trichloroethene  (ISO)
trichostatin A  (ISO)
Triptolide  (ISO)
triptonide  (ISO)
troglitazone  (ISO)
tunicamycin  (EXP)
tyrphostin AG 1478  (EXP)
urethane  (ISO)
valproic acid  (ISO)
venetoclax  (ISO)
vincristine  (ISO)
vorinostat  (ISO)
wortmannin  (EXP,ISO)
zinc acetate  (ISO)
zinc atom  (EXP,ISO)
zinc dichloride  (ISO)
zinc sulfate  (ISO)
zinc(0)  (EXP,ISO)
zoledronic acid  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
cellular response to estrogen stimulus  (IEP)
cellular response to insulin stimulus  (IDA)
cellular response to wortmannin  (IEP)
cellular response to zinc ion starvation  (IEP)
definitive hemopoiesis  (ISO)
embryonic camera-type eye morphogenesis  (ISO)
embryonic placenta development  (ISO)
embryonic process involved in female pregnancy  (ISO)
embryonic skeletal system development  (ISO)
enucleate erythrocyte differentiation  (ISO)
in utero embryonic development  (ISO)
liver development  (ISO)
lung development  (ISO)
megakaryocyte differentiation  (ISO)
mRNA transcription by RNA polymerase II  (ISO)
myeloid progenitor cell differentiation  (ISO)
neuron differentiation  (ISO)
ossification  (ISO)
positive regulation by host of viral transcription  (IEA)
positive regulation of amyloid-beta formation  (IEA,ISO)
positive regulation of angiogenesis  (IEA,ISO)
positive regulation of apoptotic signaling pathway  (IEA,ISO)
positive regulation of blood vessel endothelial cell migration  (IEA,ISO)
positive regulation of DNA-templated transcription  (IEA,ISO,ISS)
positive regulation of gene expression  (IEA,ISO)
positive regulation of hydrogen sulfide biosynthetic process  (IEA,ISO)
positive regulation of transcription by RNA polymerase II  (IC,IEA,IMP,ISO)
positive regulation of vascular endothelial cell proliferation  (IEA,ISO)
regulation of DNA-templated transcription  (IEA,ISO,ISS)
regulation of transcription by RNA polymerase II  (IBA,IMP)
response to hydroperoxide  (ISO,ISS)
retinoic acid catabolic process  (ISO)
retinoic acid receptor signaling pathway  (ISO)
rhythmic process  (IEA)
trophectodermal cell differentiation  (ISO)

Cellular Component
chromatin  (IDA,IEA,ISO)
cytoplasm  (IEA)
euchromatin  (IEA,ISO)
nucleoplasm  (IEA,ISO)
nucleus  (IDA,IEA,ISO)
protein-DNA complex  (IDA,IPI)
transcription repressor complex  (IEA,ISO)

References

References - curated
# Reference Title Reference Citation
1. Co-operative interactions between NFAT (nuclear factor of activated T cells) c1 and the zinc finger transcription factors Sp1/Sp3 and Egr-1 regulate MT1-MMP (membrane type 1 matrix metalloproteinase) transcription by glomerular mesangial cells. Alfonso-Jaume MA, etal., Biochem J. 2004 Jun 15;380(Pt 3):735-47.
2. Hyperglycemia and hyperlipidemia blunts the Insulin-Inpp5f negative feedback loop in the diabetic heart. Bai D, etal., Sci Rep. 2016 Feb 24;6:22068. doi: 10.1038/srep22068.
3. Cooperation of Sp1 and p300 in the induction of the CDK inhibitor p21WAF1/CIP1 during NGF-mediated neuronal differentiation. Billon N, etal., Oncogene. 1999 May 6;18(18):2872-82. doi: 10.1038/sj.onc.1202712.
4. Interaction of p38 and Sp1 in a mechanical force-induced, beta 1 integrin-mediated transcriptional circuit that regulates the actin-binding protein filamin-A. D'Addario M, etal., J Biol Chem 2002 Dec 6;277(49):47541-50.
5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
6. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
7. Transcriptional regulation of P450scc gene expression in the embryonic rodent nervous system. Hammer F, etal., Endocrinology 2004 Feb;145(2):901-12. Epub 2003 Oct 23.
8. Zinc deficiency decreases osteoblasts and osteoclasts associated with the reduced expression of Runx2 and RANK. Hie M, etal., Bone. 2011 Dec;49(6):1152-9. doi: 10.1016/j.bone.2011.08.019. Epub 2011 Aug 26.
9. Synergistic activation of the rat laminin gamma1 chain promoter by the gut-enriched Kruppel-like factor (GKLF/KLF4) and Sp1. Higaki Y, etal., Nucleic Acids Res 2002 Jun 1;30(11):2270-9.
10. Alterations in the DNA binding activity of transcriptional factors activator protein-1, Sp1, and hepatocyte nuclear factor-1 in rat jejunum during starvation and refeeding. Ihara T, etal., J Gastroenterol Hepatol. 2003 Jun;18(6):705-11.
11. Two regulatory proteins that bind to the basic transcription element (BTE), a GC box sequence in the promoter region of the rat P-4501A1 gene. Imataka H, etal., EMBO J 1992 Oct;11(10):3663-71.
12. Sp1 inhibits proliferation and induces apoptosis in vascular smooth muscle cells by repressing p21WAF1/Cip1 transcription and cyclin D1-Cdk4-p21WAF1/Cip1 complex formation. Kavurma MM and Khachigian LM, J Biol Chem 2003 Aug 29;278(35):32537-43. Epub 2003 Jun 9.
13. Insulin-responsive nuclear proteins facilitate Sp1 interactions with the insulin-like growth factor-I gene. Kaytor EN, etal., J Biol Chem 2001 Oct 5;276(40):36896-901. Epub 2001 Jul 16.
14. Estrogen-induced activation of hypoxia-inducible factor-1alpha, vascular endothelial growth factor expression, and edema in the uterus are mediated by the phosphatidylinositol 3-kinase/Akt pathway. Kazi AA and Koos RD, Endocrinology. 2007 May;148(5):2363-74. doi: 10.1210/en.2006-1394. Epub 2007 Feb 1.
15. Novel quantitative trait loci for blood pressure and related traits on rat chromosomes 1, 10, and 18. Kovacs P, etal., Biochem Biophys Res Commun 1997 Jun 18;235(2):343-8
16. High-density rat radiation hybrid maps containing over 24,000 SSLPs, genes, and ESTs provide a direct link to the rat genome sequence. Kwitek AE, etal., Genome Res. 2004 Apr;14(4):750-7
17. Sp1 and Egr1 regulate transcription of the Dmrt1 gene in Sertoli cells. Lei N and Heckert LL, Biol Reprod 2002 Mar;66(3):675-84.
18. Valproic acid induces functional heat-shock protein 70 via Class I histone deacetylase inhibition in cortical neurons: a potential role of Sp1 acetylation. Marinova Z, etal., J Neurochem. 2009 Nov;111(4):976-87. Epub 2009 Sep 18.
19. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
20. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
21. Involvement of nuclear transcription factor Sp1 in regulating glucose transporter-1 gene expression during rat trophoblast differentiation. Okamoto Y, etal., Biochem Biophys Res Commun 2001 Nov 9;288(4):940-8.
22. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
23. PID Annotation Import Pipeline Pipeline to import Pathway Interaction Database annotations from NCI into RGD
24. A calcium-dependent switch in a CREST-BRG1 complex regulates activity-dependent gene expression. Qiu Z and Ghosh A, Neuron. 2008 Dec 10;60(5):775-87. doi: 10.1016/j.neuron.2008.09.040.
25. A highly active homeobox gene promoter regulated by Ets and Sp1 family members in normal granulosa cells and diverse tumor cell types. Rao MK, etal., J Biol Chem 2002 Jul 19;277(29):26036-45.
26. GOA pipeline RGD automated data pipeline
27. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
28. Interaction between the two ubiquitously expressed transcription factors NF-Y and Sp1. Roder K, etal., Gene. 1999 Jun 24;234(1):61-9.
29. The trans-spliced variants of Sp1 mRNA in rat. Takahara T, etal., Biochem Biophys Res Commun 2002 Oct 18;298(1):156-62.
30. Angiotensin II-inducible platelet-derived growth factor-D transcription requires specific Ser/Thr residues in the second zinc finger region of Sp1. Tan NY, etal., Circ Res. 2008 Feb 29;102(4):e38-51. doi: 10.1161/CIRCRESAHA.107.167395. Epub 2008 Feb 7.
31. Tentative Sequence Identification Numbers Tentative Sequence Data IDs. TIGR Gene Index, Rat Data
32. The role of Sp1 and AP-2 in basal and protein kinase A--induced expression of mitochondrial serine:pyruvate aminotransferase in hepatocytes. Uchida C, etal., J Biol Chem 2002 Oct 18;277(42):39082-92.
33. Insulin-like growth factor I increases rat peptide YY promoter activity through Sp1 binding sites. Wang G, etal., Endocrinology 2004 Feb;145(2):659-66. Epub 2003 Oct 30.
34. H1t/GC-box and H1t/TE1 element are essential for promoter activity of the testis-specific histone H1t gene. Wilkerson DC, etal., Biol Reprod 2002 Oct;67(4):1157-64.
35. Sequential increase in Egr-1 and AP-1 DNA binding activity in the dentate gyrus following the induction of long-term potentiation. Williams JM, etal., Brain Res Mol Brain Res. 2000 May 5;77(2):258-66.
Additional References at PubMed
PMID:1524678   PMID:2833704   PMID:8617793   PMID:9705320   PMID:9738004   PMID:10816420   PMID:11004506   PMID:11022037   PMID:11071760   PMID:11688998   PMID:11897710   PMID:12093818  
PMID:12119294   PMID:12153142   PMID:12498690   PMID:12529372   PMID:12560508   PMID:12640146   PMID:12657651   PMID:12700237   PMID:12736330   PMID:12771217   PMID:12850056   PMID:12900380  
PMID:14563703   PMID:14580349   PMID:14593115   PMID:14604767   PMID:14630713   PMID:14643899   PMID:14667815   PMID:14701757   PMID:14744869   PMID:14988427   PMID:14988433   PMID:15016652  
PMID:15094381   PMID:15282343   PMID:15330762   PMID:15389873   PMID:15511642   PMID:15561949   PMID:15589828   PMID:15663180   PMID:15670758   PMID:15721292   PMID:15817708   PMID:15831516  
PMID:15860735   PMID:16052526   PMID:16141233   PMID:16158334   PMID:16189269   PMID:16332679   PMID:16365142   PMID:16378599   PMID:16403775   PMID:16582099   PMID:16595660   PMID:16638616  
PMID:16691198   PMID:16751776   PMID:16886906   PMID:16931573   PMID:17109817   PMID:17379926   PMID:17449871   PMID:17584888   PMID:17628354   PMID:17660393   PMID:17670746   PMID:17827154  
PMID:17872376   PMID:18004997   PMID:18192274   PMID:18293083   PMID:18348986   PMID:18367547   PMID:18434628   PMID:18443233   PMID:18543254   PMID:18568943   PMID:18655767   PMID:18850004  
PMID:19127542   PMID:19168719   PMID:19263243   PMID:19302822   PMID:19307576   PMID:19728174   PMID:19808779   PMID:19943855   PMID:20371611   PMID:20381604   PMID:20392694   PMID:20699577  
PMID:20716579   PMID:20882567   PMID:21029371   PMID:21115498   PMID:21179468   PMID:21289081   PMID:21518763   PMID:21645329   PMID:21659522   PMID:22049076   PMID:22253285   PMID:22282354  
PMID:22331133   PMID:22337869   PMID:22504846   PMID:22511764   PMID:22582096   PMID:22975163   PMID:23093703   PMID:23611784   PMID:23633075   PMID:23802567   PMID:23806282   PMID:23814049  
PMID:24006039   PMID:24030830   PMID:24244514   PMID:25148934   PMID:25388990   PMID:25476526   PMID:25923922   PMID:26012520   PMID:26547966   PMID:26779948   PMID:27030318   PMID:27053364  
PMID:27918959   PMID:28356269   PMID:28596967   PMID:29233979   PMID:29572322   PMID:31220774   PMID:35048778   PMID:36401579   PMID:36933848   PMID:37556489   PMID:38163563   PMID:38301049  
PMID:39153708   PMID:39288622  


Genomics

Comparative Map Data
Sp1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr87135,419,864 - 135,450,513 (+)NCBIGRCr8
GRCr8 Ensembl7135,420,050 - 135,450,513 (+)EnsemblGRCr8 Ensembl
mRatBN7.27133,541,302 - 133,571,961 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl7133,541,491 - 133,571,961 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx7135,298,300 - 135,327,653 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.07137,527,694 - 137,557,048 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.07137,513,816 - 137,543,172 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.07144,014,173 - 144,044,635 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl7144,014,173 - 144,044,629 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.07141,805,281 - 141,836,504 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.47141,164,180 - 141,194,509 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera7129,968,890 - 129,999,257 (+)NCBICelera
RGSC_v3.17141,240,616 - 141,265,690 (+)NCBI
RH 3.4 Map71062.1RGD
Cytogenetic Map7q36NCBI
SP1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381253,380,176 - 53,416,446 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1253,380,176 - 53,416,446 (+)EnsemblGRCh38hg38GRCh38
GRCh371253,773,960 - 53,810,230 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361252,060,246 - 52,096,497 (+)NCBINCBI36Build 36hg18NCBI36
Build 341252,060,245 - 52,096,491NCBI
Celera1253,423,138 - 53,460,427 (+)NCBICelera
Cytogenetic Map12q13.13NCBI
HuRef1250,814,656 - 50,850,614 (+)NCBIHuRef
CHM1_11253,741,140 - 53,777,425 (+)NCBICHM1_1
T2T-CHM13v2.01253,346,223 - 53,382,489 (+)NCBIT2T-CHM13v2.0
Sp1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm3915102,314,751 - 102,344,839 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl15102,314,578 - 102,344,839 (+)EnsemblGRCm39 Ensembl
GRCm3815102,406,316 - 102,436,404 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl15102,406,143 - 102,436,404 (+)EnsemblGRCm38mm10GRCm38
MGSCv3715102,236,747 - 102,266,835 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv3615102,234,362 - 102,260,713 (+)NCBIMGSCv36mm8
Celera15104,563,277 - 104,594,207 (+)NCBICelera
Cytogenetic Map15F3NCBI
cM Map1557.55NCBI
Sp1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_004955458644,378 - 677,441 (+)EnsemblChiLan1.0
ChiLan1.0NW_004955458644,435 - 677,360 (+)NCBIChiLan1.0ChiLan1.0
SP1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21040,770,223 - 40,809,774 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11240,766,986 - 40,806,525 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01235,338,492 - 35,374,462 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11236,122,583 - 36,158,356 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1236,127,681 - 36,158,356 (-)Ensemblpanpan1.1panPan2
SP1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1271,802,587 - 1,861,187 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl271,805,184 - 1,847,226 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha2744,404,740 - 44,448,820 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0271,804,038 - 1,848,490 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl271,804,038 - 1,848,385 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1271,823,470 - 1,867,184 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0271,807,708 - 1,852,315 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02744,805,663 - 44,849,851 (+)NCBIUU_Cfam_GSD_1.0
Sp1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440494562,467,059 - 62,509,967 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493651210,655,349 - 10,693,042 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_00493651210,655,116 - 10,693,025 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
SP1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl518,588,758 - 18,630,089 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1518,588,763 - 18,633,177 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2519,024,941 - 19,070,820 (+)NCBISscrofa10.2Sscrofa10.2susScr3
SP1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11149,484,459 - 49,516,941 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1149,484,518 - 49,512,541 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_023666037196,540,987 - 196,574,325 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Sp1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_0046249041,475,664 - 1,507,588 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:711
Count of miRNA genes:272
Interacting mature miRNAs:383
Transcripts:ENSRNOT00000019403
Prediction methods:Microtar, Miranda, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1354582Stl11Serum triglyceride level QTL 113.42blood triglyceride amount (VT:0002644)serum triglyceride level (CMO:0000360)7121393075137014596Rat
634331Pia17Pristane induced arthritis QTL 174.7joint integrity trait (VT:0010548)arthritic paw count (CMO:0001460)7132099939137014596Rat
731176Glom5Glomerulus QTL 52.50.0035kidney glomerulus morphology trait (VT:0005325)count of superficial glomeruli not directly contacting the kidney surface (CMO:0001002)798549867137014596Rat
1300112Bp183Blood pressure QTL 1833.51arterial blood pressure trait (VT:2000000)blood pressure time series experimental set point of the baroreceptor response (CMO:0002593)7119280025135560836Rat
61428Scl3Serum cholesterol level QTL 33.2blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)7100548246137014596Rat
61397Bw17Body weight QTL 176.3body mass (VT:0001259)body weight (CMO:0000012)795485047137014596Rat
1358914Bp266Blood pressure QTL 266arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)7115313999136544683Rat
1549899Stresp8Stress response QTL 84.370.0008stress-related behavior trait (VT:0010451)defensive burying duration (CMO:0001961)792362341137014596Rat
1358891Bp265Blood pressure QTL 2652.21arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)771827901136544683Rat
1357339Stl14Serum triglyceride level QTL 143.450.0001blood triglyceride amount (VT:0002644)serum triglyceride level (CMO:0000360)7135371291137014596Rat

Markers in Region
D18Mit9  
Rat AssemblyChrPosition (strand)SourceJBrowse
GRCr81879,484,311 - 79,484,461 (+)Marker Load Pipeline
mRatBN7.21877,209,694 - 77,209,844 (+)MAPPERmRatBN7.2
Rnor_6.01880,696,226 - 80,696,375NCBIRnor6.0
Rnor_5.01879,748,238 - 79,748,387UniSTSRnor5.0
RGSC_v3.41880,370,367 - 80,370,517RGDRGSC3.4
RGSC_v3.41880,370,368 - 80,370,517UniSTSRGSC3.4
Celera1875,835,913 - 75,836,062UniSTS
RGSC_v3.11880,443,810 - 80,444,102RGD
RH 3.4 Map18814.4RGD
RH 3.4 Map18814.4UniSTS
RH 2.0 Map1853.0RGD
SHRSP x BN Map1849.0499RGD
FHH x ACI Map1860.7699RGD
Cytogenetic Map7q36UniSTS
D7Rat105  
Rat AssemblyChrPosition (strand)SourceJBrowse
GRCr87135,432,666 - 135,432,835 (+)Marker Load Pipeline
mRatBN7.27133,554,112 - 133,554,281 (+)MAPPERmRatBN7.2
Rnor_6.07144,026,790 - 144,026,958NCBIRnor6.0
Rnor_5.07141,818,660 - 141,818,828UniSTSRnor5.0
RGSC_v3.47141,176,663 - 141,176,832RGDRGSC3.4
RGSC_v3.47141,176,664 - 141,176,832UniSTSRGSC3.4
RGSC_v3.17141,253,101 - 141,253,269RGD
RH 3.4 Map71062.4UniSTS
RH 3.4 Map71062.4RGD
RH 2.0 Map7793.5RGD
SHRSP x BN Map788.51RGD
Cytogenetic Map7q36UniSTS
X60136  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.27133,566,700 - 133,566,776 (+)MAPPERmRatBN7.2
Rnor_6.07144,039,375 - 144,039,450NCBIRnor6.0
Rnor_5.07141,831,244 - 141,831,319UniSTSRnor5.0
RGSC_v3.47141,189,249 - 141,189,324UniSTSRGSC3.4
Celera7129,993,997 - 129,994,072UniSTS
Cytogenetic Map7q36UniSTS
RH131903  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.27133,571,569 - 133,571,754 (+)MAPPERmRatBN7.2
Rnor_6.07144,044,244 - 144,044,428NCBIRnor6.0
Rnor_5.07141,836,113 - 141,836,297UniSTSRnor5.0
RGSC_v3.47141,194,118 - 141,194,302UniSTSRGSC3.4
Celera7129,998,866 - 129,999,050UniSTS
RH 3.4 Map71062.9UniSTS
Cytogenetic Map7q36UniSTS
RH132106  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.27133,558,497 - 133,558,715 (+)MAPPERmRatBN7.2
Rnor_6.07144,031,174 - 144,031,391NCBIRnor6.0
Rnor_5.07141,823,043 - 141,823,260UniSTSRnor5.0
RGSC_v3.47141,181,048 - 141,181,265UniSTSRGSC3.4
Celera7129,985,797 - 129,986,014UniSTS
RH 3.4 Map71062.9UniSTS
Cytogenetic Map7q36UniSTS
RH133875  
Rat AssemblyChrPosition (strand)SourceJBrowse
GRCr87135,446,173 - 135,446,369 (+)Marker Load Pipeline
mRatBN7.27133,567,621 - 133,567,817 (+)MAPPERmRatBN7.2
Rnor_6.07144,040,296 - 144,040,491NCBIRnor6.0
Rnor_5.07141,832,165 - 141,832,360UniSTSRnor5.0
RGSC_v3.47141,190,170 - 141,190,365UniSTSRGSC3.4
Celera7129,994,918 - 129,995,113UniSTS
RH 3.4 Map71062.7UniSTS
Cytogenetic Map7q36UniSTS
BE105685  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.27133,571,147 - 133,571,349 (+)MAPPERmRatBN7.2
Rnor_6.07144,043,822 - 144,044,023NCBIRnor6.0
Rnor_5.07141,835,691 - 141,835,892UniSTSRnor5.0
RGSC_v3.47141,193,696 - 141,193,897UniSTSRGSC3.4
Celera7129,998,444 - 129,998,645UniSTS
RH 3.4 Map71063.3UniSTS
Cytogenetic Map7q36UniSTS
PMC114562P1  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.27133,543,747 - 133,544,278 (+)MAPPERmRatBN7.2
Rnor_6.07144,016,430 - 144,016,960NCBIRnor6.0
Rnor_5.07141,808,299 - 141,808,829UniSTSRnor5.0
RGSC_v3.47141,166,303 - 141,166,833UniSTSRGSC3.4
Celera7129,971,108 - 129,971,638UniSTS
Cytogenetic Map7q36UniSTS
RH94510  
Rat AssemblyChrPosition (strand)SourceJBrowse
RH 3.4 Map71062.1UniSTS
Cytogenetic Map7q36UniSTS
RH141474  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.27133,569,621 - 133,569,819 (+)MAPPERmRatBN7.2
Rnor_6.07144,042,296 - 144,042,493NCBIRnor6.0
Rnor_5.07141,834,165 - 141,834,362UniSTSRnor5.0
RGSC_v3.47141,192,170 - 141,192,367UniSTSRGSC3.4
Celera7129,996,918 - 129,997,115UniSTS
RH 3.4 Map71065.7UniSTS
Cytogenetic Map7q36UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
9 11 49 113 91 90 59 25 59 6 218 97 11 93 45 60 31 17 17

Sequence


Ensembl Acc Id: ENSRNOT00000019403   ⟹   ENSRNOP00000019403
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl7135,420,050 - 135,450,513 (+)Ensembl
mRatBN7.2 Ensembl7133,541,491 - 133,571,961 (+)Ensembl
Rnor_6.0 Ensembl7144,014,173 - 144,044,629 (+)Ensembl
RefSeq Acc Id: NM_012655   ⟹   NP_036787
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr87135,420,050 - 135,450,513 (+)NCBI
mRatBN7.27133,541,491 - 133,571,961 (+)NCBI
Rnor_6.07144,014,173 - 144,044,635 (+)NCBI
Rnor_5.07141,805,281 - 141,836,504 (+)NCBI
RGSC_v3.47141,164,180 - 141,194,509 (+)RGD
Celera7129,968,890 - 129,999,257 (+)RGD
Sequence:
RefSeq Acc Id: XM_039078431   ⟹   XP_038934359
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr87135,420,239 - 135,450,513 (+)NCBI
mRatBN7.27133,541,803 - 133,571,961 (+)NCBI
RefSeq Acc Id: XM_039078432   ⟹   XP_038934360
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr87135,419,864 - 135,450,513 (+)NCBI
mRatBN7.27133,541,302 - 133,571,961 (+)NCBI
RefSeq Acc Id: NP_036787   ⟸   NM_012655
- UniProtKB: Q8K4R0 (UniProtKB/Swiss-Prot),   Q01714 (UniProtKB/Swiss-Prot)
- Sequence:
Ensembl Acc Id: ENSRNOP00000019403   ⟸   ENSRNOT00000019403
RefSeq Acc Id: XP_038934360   ⟸   XM_039078432
- Peptide Label: isoform X2
RefSeq Acc Id: XP_038934359   ⟸   XM_039078431
- Peptide Label: isoform X1
- UniProtKB: A6KCV1 (UniProtKB/TrEMBL)
Protein Domains
C2H2-type

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q01714-F1-model_v2 AlphaFold Q01714 1-786 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13695699
Promoter ID:EPDNEW_R6224
Type:initiation region
Name:Sp1_1
Description:Sp1 transcription factor
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.07144,014,095 - 144,014,155EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:3738 AgrOrtholog
BioCyc Gene G2FUF-31937 BioCyc
Ensembl Genes ENSRNOG00000014084 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000019403 ENTREZGENE
  ENSRNOT00000019403.7 UniProtKB/Swiss-Prot
Gene3D-CATH Classic Zinc Finger UniProtKB/Swiss-Prot
InterPro Znf_C2H2_sf UniProtKB/Swiss-Prot
  Znf_C2H2_type UniProtKB/Swiss-Prot
KEGG Report rno:24790 UniProtKB/Swiss-Prot
NCBI Gene 24790 ENTREZGENE
PANTHER KRUEPPEL-LIKE TRANSCRIPTION FACTOR UniProtKB/Swiss-Prot
  TRANSCRIPTION FACTOR SP1 UniProtKB/Swiss-Prot
Pfam zf-C2H2 UniProtKB/Swiss-Prot
PhenoGen Sp1 PhenoGen
PROSITE ZINC_FINGER_C2H2_1 UniProtKB/Swiss-Prot
  ZINC_FINGER_C2H2_2 UniProtKB/Swiss-Prot
RatGTEx ENSRNOG00000014084 RatGTEx
SMART ZnF_C2H2 UniProtKB/Swiss-Prot
Superfamily-SCOP SSF57667 UniProtKB/Swiss-Prot
TIGR TC226427
UniProt A6KCV1 ENTREZGENE, UniProtKB/TrEMBL
  Q01714 ENTREZGENE
  Q8K4R0 ENTREZGENE
  SP1_RAT UniProtKB/Swiss-Prot
UniProt Secondary Q8K4R0 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2008-09-18 Sp1  Sp1 transcription factor  Sp1  trans-acting transcription factor 1  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-02-15 Sp1  trans-acting transcription factor 1  Sp1  Sp1 transcription factor  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2002-06-10 Sp1  Sp1 transcription factor      Symbol and Name status set to approved 70586 APPROVED

RGD Curation Notes
Note Type Note Reference
gene_physical_interaction may interact with the insulin responsive binding protein IRBP to promote transcription of the IGF-1 gene 737656