Slc2a2 (solute carrier family 2 member 2) - Rat Genome Database

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Gene: Slc2a2 (solute carrier family 2 member 2) Rattus norvegicus
Analyze
Symbol: Slc2a2
Name: solute carrier family 2 member 2
RGD ID: 3705
Description: Enables D-glucose transmembrane transporter activity; dehydroascorbic acid transmembrane transporter activity; and insulin receptor binding activity. Involved in several processes, including carbohydrate utilization; dehydroascorbic acid transport; and hexose transmembrane transport. Located in several cellular components, including apical plasma membrane; basolateral plasma membrane; and brush border membrane. Human ortholog(s) of this gene implicated in Fanconi-Bickel syndrome; glycogen storage disease; and type 2 diabetes mellitus. Orthologous to human SLC2A2 (solute carrier family 2 member 2); PARTICIPATES IN facilitative sugar transporter mediated glucose transport pathway; Fanconi syndrome pathway; forkhead class A signaling pathway; INTERACTS WITH 1-naphthyl isothiocyanate; 17alpha-ethynylestradiol; 17beta-estradiol.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: glucose transporter type 2, liver; GLUT-2; Glut2; GTT2; solute carrier family 2 (facilitated glucose transporter), member 2; Solute carrier family 2 A2 (glucose transporter, type 2); solute carrier family 2, facilitated glucose transporter member 2
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Is Marker For: Strains:   SDJ/Hok  
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr82113,537,884 - 113,568,422 (+)NCBIGRCr8
mRatBN7.22111,609,798 - 111,639,930 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl2111,611,774 - 111,639,933 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx2118,264,899 - 118,292,803 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.02116,377,444 - 116,405,348 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.02111,091,060 - 111,119,103 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.02114,413,427 - 114,445,418 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl2114,413,410 - 114,445,395 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.02134,112,829 - 134,144,459 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.42116,036,501 - 116,065,834 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.12115,981,388 - 116,010,832 (+)NCBI
Celera2106,800,647 - 106,828,175 (+)NCBICelera
Cytogenetic Map2q24NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-catechin  (ISO)
(1->4)-beta-D-glucan  (ISO)
1,2-dimethylhydrazine  (ISO)
1-naphthyl isothiocyanate  (EXP)
17alpha-ethynylestradiol  (EXP,ISO)
17beta-estradiol  (EXP,ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,3,7,8-Tetrachlorodibenzofuran  (ISO)
2,4-dibromophenyl 2,4,5-tribromophenyl ether  (ISO)
2,4-dinitrotoluene  (EXP)
2,6-dinitrotoluene  (EXP)
2-amino-2-deoxy-D-glucopyranose  (EXP)
2-deoxy-D-glucose  (ISO)
3,3',4,4',5-pentachlorobiphenyl  (EXP,ISO)
3,7-dihydropurine-6-thione  (EXP)
3-(Methylthio)-1-propene  (EXP)
3-chloropropane-1,2-diol  (EXP)
3-O-methyl-D-glucose  (EXP,ISO)
3H-1,2-dithiole-3-thione  (EXP)
4,4'-sulfonyldiphenol  (ISO)
4-methylcatechol  (EXP)
5-fluorouracil  (ISO)
5-iodotubercidin  (ISO)
6-chloro-2,3,4,9-tetrahydro-1H-carbazole-1-carboxamide  (ISO)
9-cis-retinoic acid  (EXP,ISO)
acrylamide  (ISO)
actinomycin D  (EXP)
aflatoxin B1  (ISO)
aldehydo-D-glucosamine  (EXP)
aldehydo-D-glucose  (EXP,ISO)
alloxan  (EXP,ISO)
allyl isothiocyanate  (EXP)
alpha-D-galactose  (ISO)
ammonium chloride  (EXP)
aristolochic acids  (EXP)
arsenite(3-)  (ISO)
arsenous acid  (ISO)
atorvastatin calcium  (EXP,ISO)
atrazine  (EXP,ISO)
azathioprine  (ISO)
benzo[a]pyrene  (ISO)
beta-D-glucosamine  (EXP)
beta-maltose  (ISO)
bexarotene  (EXP)
bezafibrate  (EXP,ISO)
bis(2-ethylhexyl) phthalate  (EXP,ISO)
bisphenol A  (EXP,ISO)
bisphenol F  (ISO)
boric acid  (ISO)
buta-1,3-diene  (ISO)
Butylbenzyl phthalate  (ISO)
cadmium atom  (EXP)
cadmium dichloride  (EXP,ISO)
calcitriol  (ISO)
calcium atom  (EXP)
calcium(0)  (EXP)
carbon nanotube  (ISO)
CGP 52608  (ISO)
chlordecone  (ISO)
chlorpyrifos  (EXP)
cholesterol  (ISO)
choline  (ISO)
chromium(6+)  (EXP,ISO)
ciguatoxin CTX1B  (ISO)
cis-caffeic acid  (ISO)
cisplatin  (EXP)
cobalt dichloride  (EXP)
copper(II) sulfate  (ISO)
curcumin  (EXP,ISO)
cyclophosphamide  (ISO)
cyclosporin A  (ISO)
cypermethrin  (ISO)
cytochalasin B  (EXP,ISO)
D-glucose  (EXP,ISO)
D-mannopyranose  (EXP)
decabromodiphenyl ether  (EXP)
dexamethasone  (EXP)
Di-n-octyl phthalate  (ISO)
diarsenic trioxide  (ISO)
diazoxide  (EXP)
dibutyl phthalate  (ISO)
diclofenac  (ISO)
dicrotophos  (ISO)
dieldrin  (EXP)
diethyl maleate  (EXP)
diethyl phthalate  (ISO)
diethylstilbestrol  (EXP)
Diisodecyl phthalate  (ISO)
diisononyl phthalate  (ISO)
Diosbulbin B  (ISO)
dioxygen  (EXP)
diphenyl diselenide  (EXP)
diquat  (ISO)
disodium selenite  (ISO)
ebselen  (EXP,ISO)
endosulfan  (EXP,ISO)
ethanol  (EXP,ISO)
ferulic acid  (ISO)
flavonoids  (EXP)
folic acid  (ISO)
formaldehyde  (EXP)
fructose  (EXP,ISO)
furan  (EXP)
galactose  (ISO)
genistein  (EXP)
gentamycin  (EXP)
Ginsenoside Rh4  (EXP,ISO)
glafenine  (EXP)
glucose  (EXP,ISO)
glyburide  (EXP)
glycerol  (EXP)
heptachlor  (EXP)
hesperidin  (ISO)
hexadecanoic acid  (ISO)
hydrogen peroxide  (ISO)
icariin  (ISO)
imidacloprid  (EXP)
indirubin  (ISO)
indometacin  (EXP,ISO)
isoflavones  (EXP)
ketamine  (EXP)
L-dehydroascorbic acid  (ISO)
L-methionine  (ISO)
lead(0)  (ISO)
lipopolysaccharide  (ISO)
maltose  (ISO)
mercaptopurine  (EXP)
mercury dichloride  (EXP)
metacetamol  (ISO)
metformin  (ISO)
methapyrilene  (EXP)
methotrexate  (ISO)
methoxychlor  (EXP)
methylglyoxal  (ISO)
methylmercury chloride  (ISO)
microcystin-LR  (ISO)
mirex  (EXP)
ML-7  (EXP)
monosodium L-glutamate  (ISO)
Muraglitazar  (EXP)
myricetin  (EXP)
myrtenal  (EXP)
N-acetyl-L-cysteine  (ISO)
N-nitrosodiethylamine  (ISO)
N-nitrosomorpholine  (EXP)
naringin  (ISO)
nefazodone  (EXP)
nickel dichloride  (EXP)
nimesulide  (EXP)
nitrofen  (EXP)
Nonylphenol  (EXP)
O-methyleugenol  (ISO)
ochratoxin A  (EXP)
oleic acid  (ISO)
oxycodone  (EXP)
paracetamol  (ISO)
paraquat  (ISO)
penconazole  (ISO)
perfluorononanoic acid  (EXP,ISO)
perfluorooctane-1-sulfonic acid  (EXP,ISO)
perfluorooctanoic acid  (EXP,ISO)
phenobarbital  (EXP)
phloretin  (EXP,ISO)
phlorizin  (ISO)
pirinixic acid  (EXP,ISO)
potassium dichromate  (ISO)
pregnenolone 16alpha-carbonitrile  (EXP,ISO)
procymidone  (ISO)
promethazine  (EXP)
propiconazole  (ISO)
purine-6-thiol  (EXP)
quercetin  (ISO)
quercetin 3-O-beta-D-galactopyranoside  (ISO)
rebaudioside A  (ISO)
Repaglinide  (EXP)
resveratrol  (EXP,ISO)
rifampicin  (ISO)
sodium arsenite  (EXP,ISO)
sodium dichromate  (EXP)
steviol  (ISO)
stevioside  (ISO)
streptozocin  (EXP,ISO)
styrene  (EXP)
sucrose  (EXP,ISO)
taurine  (EXP,ISO)
Tesaglitazar  (EXP)
tetrachloromethane  (ISO)
tetracycline  (ISO)
thioacetamide  (EXP)
trans-caffeic acid  (ISO)
tributylstannane  (ISO)
trichloroethene  (EXP)
Triptolide  (ISO)
troglitazone  (EXP)
urethane  (ISO)
ursodeoxycholic acid  (EXP)
valdecoxib  (EXP)
valproic acid  (ISO)
vanillic acid  (ISO)
zearalenone  (ISO)
zinc atom  (EXP)
zinc(0)  (EXP)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component
apical plasma membrane  (IDA,IEA,ISO)
basolateral plasma membrane  (IDA)
brush border  (IBA,IDA,IEA,ISO)
brush border membrane  (IDA)
cell-cell junction  (IEA,ISO)
cytoplasm  (IDA,IEA,ISO)
endosome  (IDA)
plasma membrane  (IBA,IDA,IEA,ISO)

References

References - curated
# Reference Title Reference Citation
1. FDG PET imaging of Ela1-myc mice reveals major biological differences between pancreatic acinar and ductal tumours. Abasolo I, etal., Eur J Nucl Med Mol Imaging. 2009 Jul;36(7):1156-66. Epub 2009 Feb 28.
2. Cloning and characterization of rat pancreatic beta-cell/liver type glucose transporter gene: a unique exon/intron organization. Ahn YH, etal., Arch Biochem Biophys 1995 Nov 10;323(2):387-96.
3. Molecular identification and functional characterization of the vitamin C transporters expressed by Sertoli cells. Angulo C, etal., J Cell Physiol. 2008 Dec;217(3):708-16. doi: 10.1002/jcp.21545.
4. Rapid insertion of GLUT2 into the rat jejunal brush-border membrane promoted by glucagon-like peptide 2. Au A, etal., Biochem J 2002 Oct 1;367(Pt 1):247-54.
5. Insulin receptor (IR) and glucose transporter 2 (GLUT2) proteins form a complex on the rat hepatocyte membrane. Eisenberg ML, etal., Cell Physiol Biochem. 2005;15(1-4):51-8.
6. SLC2A2 gene expression in kidney of diabetic rats is regulated by HNF-1alpha and HNF-3beta. Freitas HS, etal., Mol Cell Endocrinol. 2009 Jun 16;305(1-2):63-70. Epub 2009 Mar 4.
7. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
8. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
9. Physical activity modifies the effect of SNPs in the SLC2A2 (GLUT2) and ABCC8 (SUR1) genes on the risk of developing type 2 diabetes. Kilpelainen TO, etal., Physiol Genomics. 2007 Oct 22;31(2):264-72. Epub 2007 Jul 17.
10. Characterization and partial purification of liver glucose transporter GLUT2. Lachaal M, etal., Biochim Biophys Acta. 2000 Jun 1;1466(1-2):379-89.
11. IGF alters jejunal glucose transporter expression and serum glucose levels in immature rats. Lane RH, etal., Am J Physiol Regul Integr Comp Physiol 2002 Dec;283(6):R1450-60.
12. Localization and quantification of glucose transporters in liver of growth-retarded fetal and neonatal rats. Lane RH, etal., Am J Physiol. 1999 Jan;276(1 Pt 1):E135-42.
13. Expression of the gene encoding the high-Km glucose transporter 2 by the early postimplantation mouse embryo is essential for neural tube defects associated with diabetic embryopathy. Li R, etal., Diabetologia. 2007 Mar;50(3):682-9. Epub 2007 Jan 18.
14. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
15. Role of liver-type glucose transporter (GLUT2) in transport across the basolateral membrane in rat jejunum. Miyamoto K, etal., FEBS Lett. 1992 Dec 21;314(3):466-70.
16. Apical GLUT2 and Cav1.3: regulation of rat intestinal glucose and calcium absorption. Morgan EL, etal., J Physiol. 2007 Apr 15;580(Pt. 2):593-604. Epub 2007 Feb 1.
17. A mutation in the Glut2 glucose transporter gene of a diabetic patient abolishes transport activity. Mueckler M, etal., J Biol Chem. 1994 Jul 8;269(27):17765-7.
18. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
19. Co-localization of GLUT1 and GLUT4 in the blood-brain barrier of the rat ventromedial hypothalamus. Ngarmukos C, etal., Brain Res. 2001 May 4;900(1):1-8. doi: 10.1016/s0006-8993(01)02184-9.
20. The islet beta-cell: fuel responsive and vulnerable. Nolan CJ and Prentki M, Trends Endocrinol Metab. 2008 Oct;19(8):285-91. Epub 2008 Sep 6.
21. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
22. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
23. PID Annotation Import Pipeline Pipeline to import Pathway Interaction Database annotations from NCI into RGD
24. SMPDB Annotation Import Pipeline Pipeline to import SMPDB annotations from SMPDB into RGD
25. GOA pipeline RGD automated data pipeline
26. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
27. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
28. Mutations in GLUT2, the gene for the liver-type glucose transporter, in patients with Fanconi-Bickel syndrome. Santer R, etal., Nat Genet. 1997 Nov;17(3):324-6.
29. The glucose transporter families SGLT and GLUT: molecular basis of normal and aberrant function. Scheepers A, etal., JPEN J Parenter Enteral Nutr. 2004 Sep-Oct;28(5):364-71.
30. Abnormal facilitative glucose transporter gene expression in human islet cell tumors. Seino Y, etal., J Clin Endocrinol Metab. 1993 Jan;76(1):75-8.
31. Flavonoid inhibition of sodium-dependent vitamin C transporter 1 (SVCT1) and glucose transporter isoform 2 (GLUT2), intestinal transporters for vitamin C and Glucose. Song J, etal., J Biol Chem 2002 May 3;277(18):15252-60.
32. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, etal., Proc Natl Acad Sci U S A. 2002 Dec 24;99(26):16899-903. Epub 2002 Dec 11.
33. Tentative Sequence Identification Numbers Tentative Sequence Data IDs. TIGR Gene Index, Rat Data
34. Cloning and functional expression in bacteria of a novel glucose transporter present in liver, intestine, kidney, and beta-pancreatic islet cells. Thorens B, etal., Cell. 1988 Oct 21;55(2):281-90.
35. Immunocytochemical Localization of Glucose Transporter-2 (GLUT-2) in Pancreatic Islets and Islet Cell Tumors. Tomita T Endocr Pathol. 1999 Autumn;10(3):213-221.
36. Effect of GLP-1 treatment on GLUT2 and GLUT4 expression in type 1 and type 2 rat diabetic models. Villanueva-Penacarrillo ML, etal., Endocrine 2001 Jul;15(2):241-8.
37. 20-HETE attenuates the response of glucose-stimulated insulin secretion through the AKT/GSK-3β/Glut2 pathway. Zhang B, etal., Endocrine. 2016 Nov;54(2):371-382. doi: 10.1007/s12020-016-1031-5. Epub 2016 Aug 27.
Additional References at PubMed
PMID:7589840   PMID:7593639   PMID:8457197   PMID:9751501   PMID:11287626   PMID:12436338   PMID:12526103   PMID:12766174   PMID:12787936   PMID:12921743   PMID:12963802   PMID:14702043  
PMID:14736883   PMID:15297580   PMID:15601832   PMID:15855808   PMID:16627065   PMID:16978589   PMID:17053095   PMID:17148757   PMID:17272349   PMID:17495045   PMID:17673438   PMID:17694297  
PMID:17712721   PMID:17928203   PMID:18154936   PMID:18290345   PMID:18511518   PMID:18708286   PMID:19541015   PMID:19841136   PMID:19883765   PMID:19956534   PMID:20633633   PMID:21621509  
PMID:22068967   PMID:22110271   PMID:23396969   PMID:23746671   PMID:24062089   PMID:24157454   PMID:25687571   PMID:25711084   PMID:25898949   PMID:25956617   PMID:26449613   PMID:26871756  
PMID:27662473   PMID:28011946   PMID:28083649   PMID:28470423   PMID:29178321   PMID:29386586   PMID:31767340   PMID:33513940   PMID:33724628   PMID:33856052   PMID:35843978   PMID:36173588  
PMID:37962815   PMID:38875221   PMID:38902332  


Genomics

Comparative Map Data
Slc2a2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr82113,537,884 - 113,568,422 (+)NCBIGRCr8
mRatBN7.22111,609,798 - 111,639,930 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl2111,611,774 - 111,639,933 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx2118,264,899 - 118,292,803 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.02116,377,444 - 116,405,348 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.02111,091,060 - 111,119,103 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.02114,413,427 - 114,445,418 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl2114,413,410 - 114,445,395 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.02134,112,829 - 134,144,459 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.42116,036,501 - 116,065,834 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.12115,981,388 - 116,010,832 (+)NCBI
Celera2106,800,647 - 106,828,175 (+)NCBICelera
Cytogenetic Map2q24NCBI
SLC2A2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh383170,996,347 - 171,026,720 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl3170,996,347 - 171,026,743 (-)EnsemblGRCh38hg38GRCh38
GRCh373170,714,136 - 170,744,509 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 363172,196,831 - 172,227,462 (-)NCBINCBI36Build 36hg18NCBI36
Build 343172,196,838 - 172,227,470NCBI
Celera3169,114,036 - 169,144,639 (-)NCBICelera
Cytogenetic Map3q26.2NCBI
HuRef3168,084,022 - 168,114,636 (-)NCBIHuRef
CHM1_13170,677,320 - 170,707,971 (-)NCBICHM1_1
T2T-CHM13v2.03173,780,683 - 173,811,030 (-)NCBIT2T-CHM13v2.0
Slc2a2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39328,752,052 - 28,782,510 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl328,752,052 - 28,785,508 (+)EnsemblGRCm39 Ensembl
GRCm38328,697,903 - 28,728,361 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl328,697,903 - 28,731,359 (+)EnsemblGRCm38mm10GRCm38
MGSCv37328,596,825 - 28,627,283 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36328,889,050 - 28,919,403 (+)NCBIMGSCv36mm8
Celera328,651,848 - 28,682,069 (+)NCBICelera
Cytogenetic Map3A3NCBI
cM Map312.19NCBI
Slc2a2
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554201,101,769 - 1,129,715 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049554201,101,769 - 1,129,672 (-)NCBIChiLan1.0ChiLan1.0
SLC2A2
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v22168,877,707 - 168,907,957 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan13168,882,431 - 168,912,681 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v03168,002,609 - 168,033,237 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.13176,188,184 - 176,218,722 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl3176,188,184 - 176,218,722 (-)Ensemblpanpan1.1panPan2
SLC2A2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.13435,368,583 - 35,398,197 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl3435,370,192 - 35,400,409 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha3444,378,744 - 44,410,779 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.03435,449,090 - 35,481,171 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl3435,452,303 - 35,481,052 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.13435,390,307 - 35,422,083 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.03435,359,864 - 35,391,881 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.03435,623,885 - 35,655,904 (-)NCBIUU_Cfam_GSD_1.0
Slc2a2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024405602102,013,626 - 102,049,304 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365931,572,672 - 1,604,947 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049365931,572,661 - 1,605,071 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
SLC2A2
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl13109,587,258 - 109,638,510 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.113109,592,595 - 109,614,105 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.213118,535,745 - 118,557,254 (-)NCBISscrofa10.2Sscrofa10.2susScr3
SLC2A2
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11518,434,370 - 18,466,331 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1518,434,916 - 18,467,352 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366606327,204,593 - 27,235,096 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Slc2a2
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462473049,025,766 - 49,056,284 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462473049,026,603 - 49,056,363 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Slc2a2
395 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:114
Count of miRNA genes:81
Interacting mature miRNAs:98
Transcripts:ENSRNOT00000015866
Prediction methods:Miranda, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
2293671Bss44Bone structure and strength QTL 4410.970.0001lumbar vertebra morphology trait (VT:0010494)lumbar vertebra cortical cross-sectional area (CMO:0001690)243162366148478373Rat
631566Bp90Blood pressure QTL 900.0001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)2102803808147803808Rat
1298074Bp164Blood pressure QTL 1640.003arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)242804607202447032Rat
1598865Bp296Blood pressure QTL 2962.1arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)281018907126018907Rat
1354648Bp239Blood pressure QTL 2390.001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)266118463226797303Rat
1578772Stresp14Stress response QTL 1450.001blood renin amount (VT:0003349)plasma renin activity level (CMO:0000116)282345893130923501Rat
1354649Kidm17Kidney mass QTL 172.9kidney mass (VT:0002707)calculated kidney weight (CMO:0000160)281754530227146641Rat
10755499Bp389Blood pressure QTL 3892.61arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)218960362228801039Rat
152025242Bw191Body weight QTL 1913.62body mass (VT:0001259)238573329122609194Rat
1598862Glom9Glomerulus QTL 93.5kidney glomerulus morphology trait (VT:0005325)index of glomerular damage (CMO:0001135)292337601137337601Rat
631198Cm22Cardiac mass QTL 224.30.0008heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)276539322150540526Rat
1598863Cm65Cardiac mass QTL 652.3heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)292337601137337601Rat
1302794Stl27Serum triglyceride level QTL 274.40.0001blood triglyceride amount (VT:0002644)plasma triglyceride level (CMO:0000548)225413423143657569Rat
1581569Uae32Urinary albumin excretion QTL 320.0001urine protein amount (VT:0005160)urine albumin excretion rate (CMO:0000757)278665619219826953Rat
61467Bp14Blood pressure QTL 142.2arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)243154682202446871Rat
1358901Cm38Cardiac mass QTL 382heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)225413423157142209Rat
1331760Bp206Blood pressure QTL 2063.62454arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)256043031202447032Rat
2300165Bmd49Bone mineral density QTL 494.80.0001lumbar vertebra mineral mass (VT:0010511)bone mineral density (CMO:0001226)288862519133862519Rat
1358899Kidm23Kidney mass QTL 233.88kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)225413423157142209Rat
1358908Bw49Body weight QTL 493.36body mass (VT:0001259)body weight (CMO:0000012)225413652157142078Rat
2300170Bmd45Bone mineral density QTL 4512.10.0001lumbar vertebra mineral mass (VT:0010511)volumetric bone mineral density (CMO:0001553)288862519133862519Rat
1358910Kidm27Kidney mass QTL 275.77kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)225413423157142209Rat
1358911Kidm28Kidney mass QTL 285.42kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)225413423157142209Rat
1358904Cm39Cardiac mass QTL 392.26heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)225413423157142209Rat
7411551Bw131Body weight QTL 13129.60.001body mass (VT:0001259)body weight gain (CMO:0000420)267942638112942638Rat
8662836Vetf8Vascular elastic tissue fragility QTL 80.66thoracic aorta molecular composition trait (VT:0010568)aorta wall extracellular elastin dry weight to aorta wall extracellular collagen weight ratio (CMO:0002003)2104559726149559726Rat
1358887Bw50Body weight QTL 502.39body mass (VT:0001259)body weight (CMO:0000012)225413652157142078Rat
1298080Bp163Blood pressure QTL 1630.02arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)266118275202447032Rat
8662832Vetf7Vascular elastic tissue fragility QTL 73.5aorta elastin amount (VT:0003905)aorta wall extracellular elastin dry weight to aorta wall dry weight ratio (CMO:0002002)281689826221035911Rat
1298085Bp165Blood pressure QTL 1650.0006arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)242804607202447032Rat
2290453Scl55Serum cholesterol level QTL 552.83blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)226917817136917119Rat
2299162Iddm32Insulin dependent diabetes mellitus QTL 322.36blood glucose amount (VT:0000188)age at onset/diagnosis of type 1 diabetes mellitus (CMO:0001140)278665616143657569Rat
1358894Kidm24Kidney mass QTL 244.03kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)225413423157142209Rat
2300185Bmd46Bone mineral density QTL 468.40.0001femur mineral mass (VT:0010011)volumetric bone mineral density (CMO:0001553)288862519133862519Rat
724534Uae6Urinary albumin excretion QTL 610urine albumin amount (VT:0002871)urine albumin level (CMO:0000130)278665619249053267Rat
61374Edpm2Estrogen-dependent pituitary mass QTL 24.420.86pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)276539322202447032Rat
61392Bp6Blood pressure QTL 67arterial blood pressure trait (VT:2000000)pulse pressure (CMO:0000292)280270434125270434Rat
1358917Cm42Cardiac mass QTL 422.82heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)225413423203928301Rat
1358913Cm41Cardiac mass QTL 412.73heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)225413423203928301Rat
2293835Kiddil5Kidney dilation QTL 53.8kidney pelvis morphology trait (VT:0004194)hydronephrosis severity score (CMO:0001208)242804607157142209Rat
1558653Prcr1Prostate cancer resistance QTL 15prostate integrity trait (VT:0010571)area of ventral prostate occupied by tumorous lesions to total ventral prostate area ratio (CMO:0000899)272532993157142209Rat
1354622Kidm16Kidney mass QTL 163kidney mass (VT:0002707)left kidney wet weight (CMO:0000083)281754530222436696Rat
631266Bp132Blood pressure QTL 1320.0005arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)246123260202447032Rat
7207808Bmd89Bone mineral density QTL 894.1femur strength trait (VT:0010010)femoral neck ultimate force (CMO:0001703)288862519133862519Rat
1558648Smcn1Smooth muscle cell number QTL 10.039blood vessel smooth muscle cell quantity (VT:0010525)aorta smooth muscle cell count per unit vessel length (CMO:0001646)259134147127460910Rat
2293843Kiddil6Kidney dilation QTL 63.1kidney pelvis morphology trait (VT:0004194)hydronephrosis severity score (CMO:0001208)242804607182042367Rat
152025206Hrtrt23Heart rate QTL 235.98heart pumping trait (VT:2000009)228484589169504100Rat
1354605Rf48Renal function QTL 482.9blood creatinine amount (VT:0005328)plasma creatinine level (CMO:0000537)274786664206665859Rat
152025204Hrtrt22Heart rate QTL 225.6heart pumping trait (VT:2000009)228484589169504100Rat
1354601Slep1Serum leptin concentration QTL 15.39blood leptin amount (VT:0005667)serum leptin level (CMO:0000780)243171017184114403Rat
61438Cia7Collagen induced arthritis QTL 74.60.0001joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)259324377141596857Rat
1354603Bp243Blood pressure QTL 2433.9arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)226917817127469484Rat

Markers in Region
D2Wox47  
Rat AssemblyChrPosition (strand)SourceJBrowse
Rnor_6.02114,418,676 - 114,419,081NCBIRnor6.0
RGSC_v3.42116,035,062 - 116,035,472UniSTSRGSC3.4
Celera2106,799,209 - 106,799,618UniSTS
Cytogenetic Map2q24UniSTS
RH127898  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.22111,639,700 - 111,639,895 (+)MAPPERmRatBN7.2
Rnor_6.02114,445,184 - 114,445,378NCBIRnor6.0
Rnor_5.02134,144,225 - 134,144,419UniSTSRnor5.0
RGSC_v3.42116,065,638 - 116,065,832UniSTSRGSC3.4
Celera2106,827,979 - 106,828,173UniSTS
RH 3.4 Map2702.8UniSTS
Cytogenetic Map2q24UniSTS
RH94776  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.22111,639,437 - 111,639,721 (+)MAPPERmRatBN7.2
Rnor_6.02114,444,921 - 114,445,204NCBIRnor6.0
Rnor_5.02134,143,962 - 134,144,245UniSTSRnor5.0
RGSC_v3.42116,065,375 - 116,065,658UniSTSRGSC3.4
Celera2106,827,716 - 106,827,999UniSTS
Cytogenetic Map2q24UniSTS
RH94421  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.22111,639,754 - 111,639,919 (+)MAPPERmRatBN7.2
Rnor_6.02114,445,238 - 114,445,402NCBIRnor6.0
Rnor_5.02134,144,279 - 134,144,443UniSTSRnor5.0
RGSC_v3.42116,065,692 - 116,065,856UniSTSRGSC3.4
Celera2106,828,033 - 106,828,197UniSTS
Cytogenetic Map2q24UniSTS


Related Rat Strains
The following Strains have been annotated to Slc2a2
SDJ/Hok    


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
nervous system
renal system
reproductive system
respiratory system
6 8 15 90 86 84 59 19 59 5 168 50 72 45 55 25

Sequence

Nucleotide Sequences
RefSeq Transcripts NM_012879 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006232207 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039101783 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide BC078875 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH473961 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ210842 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ218766 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  J03145 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JAXUCZ010000002 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  L28126 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  L28127 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  L28128 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  L28129 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  L28130 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  L28131 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  L28132 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  L28133 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  L28134 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  L28135 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  L28678 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Ensembl Acc Id: ENSRNOT00000015866   ⟹   ENSRNOP00000015866
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl2111,611,774 - 111,639,933 (+)Ensembl
Rnor_6.0 Ensembl2114,413,410 - 114,445,395 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000091221   ⟹   ENSRNOP00000071871
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl2111,617,982 - 111,639,933 (+)Ensembl
Rnor_6.0 Ensembl2114,423,533 - 114,444,520 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000103273   ⟹   ENSRNOP00000077553
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl2111,616,285 - 111,639,933 (+)Ensembl
RefSeq Acc Id: NM_012879   ⟹   NP_037011
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr82113,540,370 - 113,568,415 (+)NCBI
mRatBN7.22111,611,848 - 111,639,897 (+)NCBI
Rnor_6.02114,413,586 - 114,445,380 (+)NCBI
Rnor_5.02134,112,829 - 134,144,459 (+)NCBI
RGSC_v3.42116,036,501 - 116,065,834 (+)RGD
Celera2106,800,647 - 106,828,175 (+)RGD
Sequence:
RefSeq Acc Id: XM_039101783   ⟹   XP_038957711
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr82113,537,884 - 113,568,422 (+)NCBI
mRatBN7.22111,609,798 - 111,639,930 (+)NCBI
RefSeq Acc Id: NP_037011   ⟸   NM_012879
- UniProtKB: Q6LE98 (UniProtKB/Swiss-Prot),   P12336 (UniProtKB/Swiss-Prot),   Q68FZ1 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000071871   ⟸   ENSRNOT00000091221
Ensembl Acc Id: ENSRNOP00000015866   ⟸   ENSRNOT00000015866
RefSeq Acc Id: XP_038957711   ⟸   XM_039101783
- Peptide Label: isoform X1
- UniProtKB: Q6LE98 (UniProtKB/Swiss-Prot),   P12336 (UniProtKB/Swiss-Prot),   Q68FZ1 (UniProtKB/TrEMBL)
Ensembl Acc Id: ENSRNOP00000077553   ⟸   ENSRNOT00000103273
Protein Domains
Major facilitator superfamily (MFS) profile

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P12336-F1-model_v2 AlphaFold P12336 1-522 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13691268
Promoter ID:EPDNEW_R1793
Type:multiple initiation site
Name:Slc2a2_1
Description:solute carrier family 2 member 2
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.02114,413,573 - 114,413,633EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:3705 AgrOrtholog
BioCyc Gene G2FUF-53484 BioCyc
Ensembl Genes ENSRNOG00000011875 Ensembl, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000015866.7 UniProtKB/TrEMBL
  ENSRNOT00000091221.2 UniProtKB/TrEMBL
  ENSRNOT00000103273.1 UniProtKB/TrEMBL
Gene3D-CATH 1.20.1250.20 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
IMAGE_CLONE IMAGE:7127751 IMAGE-MGC_LOAD
InterPro Glc_transpt_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  GLUT UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  MFS_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  MFS_sugar_transport-like UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  MFS_trans_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Sugar/inositol_transpt UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Sugar_transporter_CS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:25351 UniProtKB/TrEMBL
MGC_CLONE MGC:93555 IMAGE-MGC_LOAD
NCBI Gene 25351 ENTREZGENE
PANTHER PTHR23503 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SOLUTE CARRIER FAMILY 2, FACILITATED GLUCOSE TRANSPORTER MEMBER 2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam Sugar_tr UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PharmGKB SLC2A2 RGD
PhenoGen Slc2a2 PhenoGen
PRINTS GLUCTRSPORT2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SUGRTRNSPORT UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE MFS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SUGAR_TRANSPORT_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SUGAR_TRANSPORT_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
RatGTEx ENSRNOG00000011875 RatGTEx
Superfamily-SCOP SSF103473 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
TIGR TC205552
UniProt A0A0G2K1J9_RAT UniProtKB/TrEMBL
  A0A8I5Y7V9_RAT UniProtKB/TrEMBL
  A6IHI9_RAT UniProtKB/TrEMBL
  A6IHJ0_RAT UniProtKB/TrEMBL
  A6IHJ1_RAT UniProtKB/TrEMBL
  GTR2_RAT UniProtKB/Swiss-Prot, ENTREZGENE
  Q68FZ1 ENTREZGENE, UniProtKB/TrEMBL
  Q6LE98 ENTREZGENE
UniProt Secondary Q6LE98 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2016-02-24 Slc2a2  solute carrier family 2 member 2  Slc2a2  solute carrier family 2 (facilitated glucose transporter), member 2  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2004-09-10 Slc2a2  solute carrier family 2 (facilitated glucose transporter), member 2    solute carrier family 2, member 2  Name updated 1299863 APPROVED
2003-04-09 Slc2a2  solute carrier family 2, member 2    Solute carrier family 2 A2 (gkucose transporter, type 2)  Name updated 629478 APPROVED
2002-06-10 Slc2a2  Solute carrier family 2 A2 (gkucose transporter, type 2)      Symbol and Name status set to approved 70586 APPROVED

RGD Curation Notes
Note Type Note Reference
gene_cellular_localization protein localized to jejunal brush border membranes 625552
gene_cellular_localization localized to apical plasma membrane and basolateral membrane 625552
gene_expression expressed in jejunal brush-border membrane 625552
gene_function functions as a transporter of glucose, galactose and fructose 625552
gene_process has low substrate affinity and Km value in the range of 16-20 mM 625552
gene_process involved in hexose transport into enterocytes 625552
gene_process may play a role in hexose transport across intestinal brush border membranes  
gene_regulation regulated by vascular GLP-2 and/or luminal glucose 625552
gene_regulation glucose transporter activity is inhibited by the flavonol quercetin 730195