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Gene: Slc1a1 (solute carrier family 1 member 1) Rattus norvegicus
Symbol: Slc1a1
Name: solute carrier family 1 member 1
RGD ID: 3696
Description: Exhibits dicarboxylic acid transmembrane transporter activity; glutamate binding activity; and identical protein binding activity. Involved in L-glutamate transmembrane transport. Localizes to several cellular components, including dendrite; perikaryon; and synaptic cleft. Human ortholog(s) of this gene implicated in dicarboxylic aminoaciduria and schizophrenia 18. Orthologous to human SLC1A1 (solute carrier family 1 member 1); PARTICIPATES IN amiloride pharmacodynamics pathway; bendroflumethiazide pharmacodynamics pathway; bumetanide pharmacodynamics pathway; INTERACTS WITH (+)-pilocarpine; (R)-lipoic acid; (S)-nicotine.
Type: protein-coding
Also known as: Eaac1; Eaat3; excitatory amino acid carrier 1; excitatory amino acid transporter 3; excitatory amino acid transporter-3; excitatory amino-acid carrier 1; REAAC1; sodium-dependent glutamate/aspartate transporter 3; solute carrier family 1 (neuronal/epithelial high affinity glutamate transporter, system Xag), member 1; Solute carrier family 1 A1 (brain glutamate transporter); solute carrier family 1, member 1
Homo sapiens (human) : SLC1A1 (solute carrier family 1 member 1)  HGNC  Alliance
Mus musculus (house mouse) : Slc1a1 (solute carrier family 1 (neuronal/epithelial high affinity glutamate transporter, system Xag), member 1)  MGI  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Slc1a1 (solute carrier family 1 member 1)
Pan paniscus (bonobo/pygmy chimpanzee) : SLC1A1 (solute carrier family 1 member 1)
Canis lupus familiaris (dog) : SLC1A1 (solute carrier family 1 member 1)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Slc1a1 (solute carrier family 1 member 1)
Sus scrofa (pig) : SLC1A1 (solute carrier family 1 member 1)
Chlorocebus sabaeus (African green monkey) : SLC1A1 (solute carrier family 1 member 1)
Heterocephalus glaber (naked mole-rat) : Slc1a1 (solute carrier family 1 member 1)
more info ...
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
Rat AssemblyChrPosition (strand)SourceGenome Browsers
Rnor_6.01246,955,017 - 247,035,159 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1246,954,980 - 247,037,056 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01254,195,480 - 254,274,919 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41232,469,746 - 232,549,584 (+)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.11232,633,737 - 232,715,504 (+)NCBI
Celera1223,704,163 - 223,782,895 (+)NCBICelera
Cytogenetic Map1q52NCBI
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
QTLs in Region (Rnor_6.0)
miRNA Target Status


RNA-SEQ Expression


Nucleotide Sequences
Protein Sequences

Strain Variation

Strain Sequence Variants (Rnor 6.0)

Additional Information

External Database Links
Nomenclature History
RGD Curation Notes
More on Slc1a1
Alliance Gene
Ensembl Gene
JBrowse: rn5 rn6
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 3696
Created: 2000-05-25
Species: Rattus norvegicus
Last Modified: 2020-10-06
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.