Si (sucrase-isomaltase) - Rat Genome Database

Name: Si
Creator: Rat Genome Database
License: Creative Commons CC BY 4.0
Keywords: Rat Gene RGD Genome

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Gene: Si (sucrase-isomaltase) Rattus norvegicus

Analyze

Symbol:

Name:

sucrase-isomaltase

RGD ID:

3675

Description:

Enables beta-fructofuranosidase activity and oligo-1,6-glucosidase activity. Involved in several processes, including response to fructose; response to insulin; and response to vitamin A. Located in brush border. Biomarker of colitis. Human ortholog(s) of this gene implicated in congenital sucrase-isomaltase deficiency. Orthologous to human SI (sucrase-isomaltase); PARTICIPATES IN congenital sucrase-isomaltase deficiency pathway; glycogen storage disease type III pathway; glycogen storage disease type IV pathway; INTERACTS WITH (S)-naringenin; 17alpha-ethynylestradiol; acetylsalicylic acid.

Type:

protein-coding

RefSeq Status:

VALIDATED

Previously known as:

SUCIMAL; sucrase-isomaltase (alpha-glucosidase); sucrase-isomaltase, intestinal

RGD Orthologs

Alliance Genes

More Info

more info ...

More Info

Species	Gene symbol and name	Data Source	Assertion derived from	less info ...
Orthologs ¹				less info ...
Homo sapiens (human):	SI (sucrase-isomaltase)	HGNC	EggNOG, Ensembl, HomoloGene, Inparanoid, NCBI, OMA, OrthoDB, Panther, Treefam
Mus musculus (house mouse):	Sis (sucrase isomaltase)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chinchilla lanigera (long-tailed chinchilla):	Si (sucrase-isomaltase)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Pan paniscus (bonobo/pygmy chimpanzee):	SI (sucrase-isomaltase)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Canis lupus familiaris (dog):	SI (sucrase-isomaltase)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Ictidomys tridecemlineatus (thirteen-lined ground squirrel):	Si (sucrase-isomaltase)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Sus scrofa (pig):	SI (sucrase-isomaltase)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chlorocebus sabaeus (green monkey):	SI (sucrase-isomaltase)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Heterocephalus glaber (naked mole-rat):	Si (sucrase-isomaltase)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Other homologs ²
Homo sapiens (human):	KXD1 (KxDL motif containing 1)	HGNC	OMA
Alliance orthologs ³
Homo sapiens (human):	SI (sucrase-isomaltase)	Alliance	DIOPT (Ensembl Compara\|HGNC\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Mus musculus (house mouse):	Sis (sucrase isomaltase)	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Danio rerio (zebrafish):	si (sucrase-isomaltase (alpha-glucosidase))	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OrthoFinder\|OrthoInspector\|PhylomeDB\|SonicParanoid)
Caenorhabditis elegans (roundworm):	aagr-1	Alliance	DIOPT (OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Caenorhabditis elegans (roundworm):	aagr-2	Alliance	DIOPT (Ensembl Compara\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Xenopus tropicalis (tropical clawed frog):	adamts4	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|OrthoFinder\|PANTHER)
Xenopus tropicalis (tropical clawed frog):	mgam	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|OrthoFinder\|PANTHER)

Latest Assembly:

mRatBN7.2 - mRatBN7.2 Assembly

Position:

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
mRatBN7.2	2	157,505,893 - 157,586,228 (-)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	2	157,506,342 - 157,585,260 (-)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	2	164,628,371 - 164,709,000 (-)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	2	162,678,862 - 162,759,493 (-)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	2	157,311,634 - 157,392,265 (-)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	2	170,220,794 - 170,301,348 (-)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	2	170,221,245 - 170,301,348 (-)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	2	189,563,145 - 189,643,699 (-)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	2	163,520,975 - 163,601,280 (-)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
RGSC_v3.1	2	163,470,937 - 163,551,243 (-)	NCBI
Celera	2	151,764,945 - 151,845,208 (-)	NCBI		Celera
RH 3.4 Map	2	1027.6	RGD
Cytogenetic Map	2	q32	NCBI

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

colitis (IEP)

congenital sucrase-isomaltase deficiency (ISO)

Experimental Diabetes Mellitus (IEP)

genetic disease (ISO)

Insulin Resistance (IEP)

prostate cancer (ISO)

Reperfusion Injury (IEP)

Starvation (IEP)

Gene-Chemical Interaction Annotations Click to see Annotation Detail View

(S)-naringenin (EXP,ISO)

1,2-dimethylhydrazine (ISO)

1,4-phenylenediamine (ISO)

1-chloro-2,4-dinitrobenzene (ISO)

17alpha-ethynylestradiol (EXP)

2,3,7,8-tetrachlorodibenzodioxine (ISO)

acetylsalicylic acid (EXP,ISO)

aflatoxin B1 (ISO)

aldehydo-D-glucose (ISO)

ammonium chloride (EXP)

arsenic acid (ISO)

arsenous acid (ISO)

Azaspiracid (ISO)

berberine (EXP,ISO)

bisphenol A (EXP,ISO)

calcitriol (ISO)

celecoxib (EXP)

D-glucose (ISO)

diarsenic trioxide (ISO)

endosulfan (EXP)

fructose (EXP,ISO)

furan (EXP)

gamma-hexachlorocyclohexane (EXP)

glucose (ISO)

glycerol (EXP)

L-ascorbic acid (ISO)

mono(2-ethylhexyl) phthalate (ISO)

N-[2-(4-bromocinnamylamino)ethyl]isoquinoline-5-sulfonamide (ISO)

nimesulide (EXP)

ozone (ISO)

paraquat (EXP)

phosalone (EXP)

potassium dichromate (ISO)

quercetin (ISO)

sodium fluoride (ISO)

sucrose (EXP)

testosterone (ISO)

Voglibose (EXP)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

carbohydrate metabolic process (IEA)

response to fructose (IEP)

response to glucocorticoid (IEP)

response to insulin (IEP)

response to nutrient (IEP)

response to starvation (IEP)

response to sucrose (IEP)

response to vitamin A (IEP)

sucrose catabolic process (IEA,ISO)

Cellular Component

apical plasma membrane (IEA)

brush border (IDA)

membrane (IEA,ISO)

Molecular Function

alpha-1,4-glucosidase activity (IBA)

alpha-glucosidase activity (IEA)

beta-fructofuranosidase activity (IDA)

carbohydrate binding (IEA)

oligo-1,6-glucosidase activity (IDA,IEA,ISO)

protein binding (IPI)

sucrose alpha-glucosidase activity (IEA)

Molecular Pathway Annotations Click to see Annotation Detail View

congenital sucrase-isomaltase deficiency pathway (ISO)

glycogen storage disease type III pathway (ISO)

glycogen storage disease type IV pathway (ISO)

glycogen storage disease type VI pathway (ISO)

starch and sucrose metabolic pathway (IEA,ISO)

References

References - curated

#	Reference Title	Reference Citation
1.	Disordered expression of the sucrase-isomaltase complex in the small intestine in Otsuka Long-Evans tokushima fatty rats, a model of non-insulin-dependent diabetes mellitus with insulin resistance.	Adachi T, etal., Biochim Biophys Acta. 1999 Jan 4;1426(1):126-32.
2.	Morphological changes and increased sucrase and isomaltase activity in small intestines of insulin-deficient and type 2 diabetic rats.	Adachi T, etal., Endocr J. 2003 Jun;50(3):271-9.
3.	Mucosal function in rat jejunum and ileum is altered by induction of colitis.	Amit-Romach E, etal., Int J Mol Med. 2006 Oct;18(4):721-7.
4.	Premature stimulation of rat sucrase-isomaltase (SI) by exogenous insulin and the analog B-Asp10 is regulated by a receptor-mediated signal triggering SI gene transcription.	Buts JP, etal., Pediatr Res. 1998 May;43(5):585-91.
5.	Cloning and sequencing of a full-length rat sucrase-isomaltase-encoding cDNA.	Chandrasena G, etal., Gene 1994 Dec 15;150(2):355-60.
6.	Sucrase-isomaltase gene expression in suckling rat intestine: hormonal, dietary, and growth factor control.	Emvo EN, etal., J Pediatr Gastroenterol Nutr. 1996 Oct;23(3):262-9.
7.	Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium.	Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
8.	Rat ISS GO annotations from GOA human gene data--August 2006	GOA data from the GO Consortium
9.	Biosynthesis of sucrase-isomaltase. Purification and NH2-terminal amino acid sequence of the rat sucrase-isomaltase precursor (pro-sucrase-isomaltase) from fetal intestinal transplants.	Hauri HP, etal., J Biol Chem. 1982 Apr 25;257(8):4522-8.
10.	Enhancement of brush border membrane peptidase activity in rat jejunum induced by starvation.	Ihara T, etal., Pflugers Arch. 2000 May;440(1):75-83.
11.	KEGG: Kyoto Encyclopedia of Genes and Genomes	KEGG
12.	Enhancement of sucrase-isomaltase gene expression induced by luminally administered fructose in rat jejunum.	Kishi K, etal., J Nutr Biochem. 1999 Jan;10(1):8-12.
13.	High-density rat radiation hybrid maps containing over 24,000 SSLPs, genes, and ESTs provide a direct link to the rat genome sequence.	Kwitek AE, etal., Genome Res. 2004 Apr;14(4):750-7
14.	Total intestinal lactase and sucrase activities are reduced in aged rats.	Lee MF, etal., J Nutr. 1997 Jul;127(7):1382-7.
15.	Sucrase-isomaltase ontogeny: synergism between glucocorticoids and thyroxine reflects increased mRNA and no change in cell migration.	Leeper LL, etal., Biochem Biophys Res Commun. 1998 May 29;246(3):765-70.
16.	Electronic Transfer of LocusLink and RefSeq Data	NCBI rat LocusLink and RefSeq merged data July 26, 2002
17.	OMIM Disease Annotation Pipeline	OMIM Disease Annotation Pipeline
18.	KEGG Annotation Import Pipeline	Pipeline to import KEGG annotations from KEGG into RGD
19.	SMPDB Annotation Import Pipeline	Pipeline to import SMPDB annotations from SMPDB into RGD
20.	GOA pipeline	RGD automated data pipeline
21.	ClinVar Automated Import and Annotation Pipeline	RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
22.	Data Import for Chemical-Gene Interactions	RGD automated import pipeline for gene-chemical interactions
23.	Characteristics and structural requirements of apical sorting of the rat growth hormone through the O-glycosylated stalk region of intestinal sucrase-isomaltase.	Spodsberg N, etal., J Biol Chem 2001 Dec 7;276(49):46597-604.
24.	Regulation of sucrase-isomaltase gene expression along the crypt-villus axis of rat small intestine.	Traber PG Biochem Biophys Res Commun 1990 Dec 31;173(3):765-73.
25.	A role for myosin-1A in the localization of a brush border disaccharidase.	Tyska MJ and Mooseker MS, J Cell Biol. 2004 May 10;165(3):395-405.
26.	Dietary regulation of sucrase-isomaltase gene expression in rat jejunum.	Yasutake H, etal., Biochim Biophys Acta. 1995 Feb 23;1243(2):270-6.
27.	Expression of intestinal brush-border membrane hydrolases and ferritin after segmental ischemia-reperfusion in rats.	Yeh KY, etal., Am J Physiol. 1998 Sep;275(3 Pt 1):G572-83.
28.	Vitamin A exerts its activity at the transcriptional level in the small intestine.	Zaiger G, etal., Eur J Nutr. 2004 Oct;43(5):259-66. Epub 2004 Jan 28.

Additional References at PubMed

PMID:2400788	PMID:17272516	PMID:17673438	PMID:18313392	PMID:18617558	PMID:19352013	PMID:20356844	PMID:22896899	PMID:23533145	PMID:36329653

Genomics

Comparative Map Data

Si
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
mRatBN7.2	2	157,505,893 - 157,586,228 (-)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	2	157,506,342 - 157,585,260 (-)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	2	164,628,371 - 164,709,000 (-)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	2	162,678,862 - 162,759,493 (-)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	2	157,311,634 - 157,392,265 (-)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	2	170,220,794 - 170,301,348 (-)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	2	170,221,245 - 170,301,348 (-)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	2	189,563,145 - 189,643,699 (-)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	2	163,520,975 - 163,601,280 (-)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
RGSC_v3.1	2	163,470,937 - 163,551,243 (-)	NCBI
Celera	2	151,764,945 - 151,845,208 (-)	NCBI		Celera
RH 3.4 Map	2	1027.6	RGD
Cytogenetic Map	2	q32	NCBI

SI
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	3	164,978,898 - 165,157,921 (-)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	3	164,978,898 - 165,078,496 (-)	Ensembl	GRCh38		hg38	GRCh38
GRCh37	3	164,696,686 - 164,796,284 (-)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	3	166,179,380 - 166,278,976 (-)	NCBI	NCBI36	Build 36	hg18	NCBI36
Build 34	3	166,179,388 - 166,278,984	NCBI
Celera	3	163,095,850 - 163,195,264 (-)	NCBI		Celera
Cytogenetic Map	3	q26.1	NCBI
HuRef	3	162,066,552 - 162,166,109 (-)	NCBI		HuRef
CHM1_1	3	164,659,546 - 164,759,127 (-)	NCBI		CHM1_1
T2T-CHM13v2.0	3	167,761,814 - 167,940,822 (-)	NCBI		T2T-CHM13v2.0

Sis
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	3	72,795,890 - 72,875,196 (-)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	3	72,795,890 - 72,875,196 (-)	Ensembl		GRCm39 Ensembl
GRCm38	3	72,888,557 - 72,967,863 (-)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	3	72,888,557 - 72,967,863 (-)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	3	72,692,482 - 72,770,788 (-)	NCBI	GRCm37	MGSCv37	mm9	NCBIm37
MGSCv36	3	72,976,489 - 73,055,789 (-)	NCBI		MGSCv36	mm8
Celera	3	73,012,488 - 73,086,863 (-)	NCBI		Celera
Cytogenetic Map	3	E3	NCBI
cM Map	3	32.59	NCBI

Si
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955448	14,685,963 - 14,777,338 (-)	Ensembl	ChiLan1.0
ChiLan1.0	NW_004955448	14,686,315 - 14,777,298 (-)	NCBI	ChiLan1.0	ChiLan1.0

SI
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1	3	162,881,729 - 162,981,543 (-)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	3	161,961,038 - 162,104,054 (-)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	3	170,057,282 - 170,156,983 (-)	NCBI	panpan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	3	170,057,750 - 170,154,502 (-)	Ensembl	panpan1.1		panPan2

SI
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	34	30,284,869 - 30,373,749 (-)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	34	30,284,858 - 30,373,780 (-)	Ensembl	CanFam3.1		canFam3	CanFam3.1
Dog10K_Boxer_Tasha	34	39,346,430 - 39,434,804 (-)	NCBI		Dog10K_Boxer_Tasha
ROS_Cfam_1.0	34	30,347,263 - 30,435,400 (-)	NCBI		ROS_Cfam_1.0
UMICH_Zoey_3.1	34	30,290,443 - 30,378,872 (-)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	34	30,241,911 - 30,330,433 (-)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	34	30,511,922 - 30,599,883 (-)	NCBI		UU_Cfam_GSD_1.0

Si
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024405602	96,367,610 - 96,445,267 (-)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936707	1,153,538 - 1,228,220 (-)	Ensembl	SpeTri2.0
SpeTri2.0	NW_004936707	1,153,538 - 1,228,220 (-)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

SI
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	13	104,296,283 - 104,379,478 (-)	Ensembl	Sscrofa11.1		susScr11	Sscrofa11.1
Sscrofa11.1	13	104,296,281 - 104,379,558 (-)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	13	112,716,702 - 112,812,308 (-)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

SI
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	15	24,480,060 - 24,582,468 (+)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	15	24,482,865 - 24,582,394 (+)	Ensembl	ChlSab1.1	ChlSab1.1 Ensembl	chlSab2
Vero_WHO_p1.0	NW_023666063	33,458,175 - 33,557,570 (+)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Si
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624730	42,984,431 - 43,112,819 (-)	Ensembl	HetGla_female_1.0	HetGla_female_1.0 Ensembl	hetGla2
HetGla 1.0	NW_004624730	42,984,277 - 43,112,819 (-)	NCBI	HetGla_female_1.0	HetGla 1.0	hetGla2

Variants

Variants in Si
880 total Variants

miRNA Target Status

Predicted Target Of

	Summary Value
Count of predictions:	89
Count of miRNA genes:	74
Interacting mature miRNAs:	78
Transcripts:	ENSRNOT00000046681
Prediction methods:	Microtar, Miranda, Rnahybrid
Result types:	miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.

QTLs in Region (mRatBN7.2)

The following QTLs overlap with this region.

RGD ID	Symbol	Name	LOD	P Value	Trait	Sub Trait	Chr	Start	Stop	Species
61467	Bp14	Blood pressure QTL 14	2.2		arterial blood pressure trait (VT:2000000)	diastolic blood pressure (CMO:0000005)	2	43154682	202446871	Rat
61467	Bp14	Blood pressure QTL 14	2.2		arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	2	43154682	202446871	Rat
2301966	Bp322	Blood pressure QTL 322	3.58		arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	2	150540301	202447032	Rat
1354648	Bp239	Blood pressure QTL 239		0.001	arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	2	66118463	226797303	Rat
1354622	Kidm16	Kidney mass QTL 16	3		kidney mass (VT:0002707)	left kidney wet weight (CMO:0000083)	2	81754530	222436696	Rat
1354649	Kidm17	Kidney mass QTL 17	2.9		kidney mass (VT:0002707)	calculated kidney weight (CMO:0000160)	2	81754530	227146641	Rat
1331805	Cm29	Cardiac mass QTL 29	3.50746		heart mass (VT:0007028)	heart wet weight (CMO:0000069)	2	141194931	223265385	Rat
1359032	Hrtrt18	Heart rate QTL 18			heart pumping trait (VT:2000009)	heart rate (CMO:0000002)	2	157142078	192625452	Rat
631507	Bp105	Blood pressure QTL 105		0.001	arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	2	112456140	212696837	Rat
1331794	Bp202	Blood pressure QTL 202	3.66819		arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	2	141194931	223265385	Rat
1354609	Niddm62	Non-insulin dependent diabetes mellitus QTL 62	4.72	0.000006	insulin secretion trait (VT:0003564)	plasma insulin level (CMO:0000342)	2	150540301	202447032	Rat
1354601	Slep1	Serum leptin concentration QTL 1	5.39		blood leptin amount (VT:0005667)	serum leptin level (CMO:0000780)	2	43171017	184114403	Rat
1302793	Bw16	Body weight QTL 16	5	0.0001	body mass (VT:0001259)	body weight (CMO:0000012)	2	157142209	202446871	Rat
6903312	Bw112	Body weight QTL 112	3.2	0.0013	body mass (VT:0001259)	body weight (CMO:0000012)	2	143657569	184114274	Rat
1581569	Uae32	Urinary albumin excretion QTL 32		0.0001	urine protein amount (VT:0005160)	urine albumin excretion rate (CMO:0000757)	2	78665619	219826953	Rat
1300165	Rf9	Renal function QTL 9	3.28		kidney glomerulus integrity trait (VT:0010546)	index of glomerular damage (CMO:0001135)	2	133914684	202447032	Rat
2301415	Cm67	Cardiac mass QTL 67		0.003	heart mass (VT:0007028)	heart wet weight to body weight ratio (CMO:0002408)	2	152413072	175950118	Rat
10043136	Iddm54	Insulin dependent diabetes mellitus QTL 54	3.4	0.0001	blood glucose amount (VT:0000188)	blood glucose level (CMO:0000046)	2	143657411	190602963	Rat
1581502	Esta3	Estrogen-induced thymic atrophy QTL 3			thymus mass (VT:0004954)	thymus wet weight (CMO:0000855)	2	136916935	189599348	Rat
10043136	Iddm54	Insulin dependent diabetes mellitus QTL 54	3.4	0.0001	blood glucose amount (VT:0000188)	age at onset/diagnosis of type 1 diabetes mellitus (CMO:0001140)	2	143657411	190602963	Rat
1298074	Bp164	Blood pressure QTL 164		0.003	arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	2	42804607	202447032	Rat
1298076	Bp166	Blood pressure QTL 166		0.0009	arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	2	136445150	202447032	Rat
1298085	Bp165	Blood pressure QTL 165		0.0006	arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	2	42804607	202447032	Rat
8662832	Vetf7	Vascular elastic tissue fragility QTL 7	3.5		aorta elastin amount (VT:0003905)	aorta wall extracellular elastin dry weight to aorta wall dry weight ratio (CMO:0002002)	2	81689826	221035911	Rat
12879838	Cm86	Cardiac mass QTL 86		0.002	heart left ventricle mass (VT:0007031)	heart left ventricle weight to body weight ratio (CMO:0000530)	2	152413072	185122374	Rat
12879846	Cm90	Cardiac mass QTL 90		0.011	heart right ventricle mass (VT:0007033)	heart right ventricle weight to body weight ratio (CMO:0000914)	2	152413072	175950118	Rat
1331760	Bp206	Blood pressure QTL 206	3.62454		arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	2	56043031	202447032	Rat
1598805	Memor8	Memory QTL 8	3		exploratory behavior trait (VT:0010471)	average horizontal distance between subject and target during voluntary locomotion in an experimental apparatus (CMO:0002674)	2	150341585	189039377	Rat
1641925	Alcrsp2	Alcohol response QTL 2			response to alcohol trait (VT:0010489)	duration of loss of righting reflex (CMO:0002289)	2	149559561	221167075	Rat
1354594	Despr10	Despair related QTL 10		0.00000249	locomotor behavior trait (VT:0001392)	amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)	2	114654253	159654253	Rat
12879845	Cm89	Cardiac mass QTL 89		0.008	heart left ventricle mass (VT:0007031)	heart left ventricle weight to body weight ratio (CMO:0000530)	2	152413072	175950118	Rat
1641891	Alcrsp17	Alcohol response QTL 17			response to alcohol trait (VT:0010489)	duration of loss of righting reflex (CMO:0002289)	2	149559561	249053267	Rat
631501	Bp101	Blood pressure QTL 101	2.4		arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	2	150341684	202446871	Rat
724534	Uae6	Urinary albumin excretion QTL 6	10		urine albumin amount (VT:0002871)	urine albumin level (CMO:0000130)	2	78665619	249053267	Rat
724568	Uae13	Urinary albumin excretion QTL 13	4.4		urine albumin amount (VT:0002871)	urine albumin excretion rate (CMO:0000757)	2	143157029	210020885	Rat
631266	Bp132	Blood pressure QTL 132		0.0005	arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	2	46123260	202447032	Rat
1298080	Bp163	Blood pressure QTL 163		0.02	arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	2	66118275	202447032	Rat
61401	Niddm2	Non-insulin dependent diabetes mellitus QTL 2	4.54		blood glucose amount (VT:0000188)	blood glucose level (CMO:0000046)	2	144599348	189599348	Rat
1354605	Rf48	Renal function QTL 48	2.9		blood creatinine amount (VT:0005328)	plasma creatinine level (CMO:0000537)	2	74786664	206665859	Rat
1358913	Cm41	Cardiac mass QTL 41	2.73		heart mass (VT:0007028)	heart weight to body weight ratio (CMO:0000074)	2	25413423	203928301	Rat
1358917	Cm42	Cardiac mass QTL 42	2.82		heart mass (VT:0007028)	heart weight to body weight ratio (CMO:0000074)	2	25413423	203928301	Rat
1358900	Bw48	Body weight QTL 48	4.88		body mass (VT:0001259)	body weight (CMO:0000012)	2	157142078	211086598	Rat
1554319	Bmd2	Bone mineral density QTL 2	13.4	0.0001	lumbar vertebra area (VT:0010570)	lumbar vertebra cross-sectional area (CMO:0001689)	2	114837675	212549332	Rat
1598833	Bp295	Blood pressure QTL 295	3.5		arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	2	147798556	192798556	Rat
2293843	Kiddil6	Kidney dilation QTL 6	3.1		kidney pelvis morphology trait (VT:0004194)	hydronephrosis severity score (CMO:0001208)	2	42804607	182042367	Rat
634308	Sach6	Saccharin preference QTL 6	4.9		taste sensitivity trait (VT:0001986)	saccharin intake volume to total fluid intake volume ratio (CMO:0001601)	2	112456140	212696837	Rat
738007	Anxrr7	Anxiety related response QTL 7	4.4		exploratory behavior trait (VT:0010471)	number of entries into a discrete space in an experimental apparatus (CMO:0000960)	2	118189491	163189491	Rat
61374	Edpm2	Estrogen-dependent pituitary mass QTL 2	4.42	0.86	pituitary gland mass (VT:0010496)	pituitary gland wet weight (CMO:0000853)	2	76539322	202447032	Rat
1359030	Bp277	Blood pressure QTL 277			arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	2	114837527	185876470	Rat
1359030	Bp277	Blood pressure QTL 277			arterial blood pressure trait (VT:2000000)	diastolic blood pressure (CMO:0000005)	2	114837527	185876470	Rat
1359022	Ppulsi1	Prepulse inhibition QTL 1	3.63		prepulse inhibition trait (VT:0003088)	acoustic startle response measurement (CMO:0001519)	2	136916935	213594495	Rat
70175	BpQTLCluster3	Blood pressure QTL cluster 3	4.128		arterial blood pressure trait (VT:2000000)	diastolic blood pressure (CMO:0000005)	2	135552573	202446871	Rat
70175	BpQTLCluster3	Blood pressure QTL cluster 3	4.128		arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	2	135552573	202446871	Rat
70175	BpQTLCluster3	Blood pressure QTL cluster 3	4.128		arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	2	135552573	202446871	Rat
70175	BpQTLCluster3	Blood pressure QTL cluster 3	4.128		arterial blood pressure trait (VT:2000000)	pulse pressure (CMO:0000292)	2	135552573	202446871	Rat
71113	Cari2	Carrageenan-induced inflammation QTL 2	2.7	0.009	hypodermis integrity trait (VT:0010550)	inflammatory exudate volume (CMO:0001429)	2	141596551	202447032	Rat
70175	BpQTLCluster3	Blood pressure QTL cluster 3	4.128		arterial blood pressure trait (VT:2000000)	absolute change in systolic blood pressure (CMO:0000607)	2	135552573	202446871	Rat
6907363	Bp357	Blood pressure QTL 357	4.1	0.002	arterial blood pressure trait (VT:2000000)	diastolic blood pressure (CMO:0000005)	2	129540907	174540907	Rat
631520	Bp73	Blood pressure QTL 73		0.0001	arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	2	147686913	168355276	Rat
1578648	Bss11	Bone structure and strength QTL 11	4.7		femur morphology trait (VT:0000559)	femoral neck cortical cross-sectional area (CMO:0001702)	2	114837527	211674221	Rat
11565180	Kidm56	Kidney mass QTL 56		0.003	kidney mass (VT:0002707)	both kidneys wet weight to body weight ratio (CMO:0000340)	2	152413072	175950118	Rat
11565181	Bw176	Body weight QTL 176		0.002	body mass (VT:0001259)	body weight (CMO:0000012)	2	152413072	175950118	Rat
8662843	Vetf9	Vascular elastic tissue fragility QTL 9	2.05		thoracic aorta molecular composition trait (VT:0010568)	aorta wall extracellular elastin dry weight to aorta wall extracellular collagen weight ratio (CMO:0002003)	2	157142078	226277316	Rat
12879840	Bw179	Body weight QTL 179		0.005	body mass (VT:0001259)	body weight (CMO:0000012)	2	152413072	185122374	Rat
12879836	Kidm61	Kidney mass QTL 61		0.001	kidney mass (VT:0002707)	both kidneys wet weight to body weight ratio (CMO:0000340)	2	152413072	185122374	Rat
12879839	Cm85	Cardiac mass QTL 85		0.001	heart mass (VT:0007028)	heart wet weight to body weight ratio (CMO:0002408)	2	152413072	185122374	Rat
12879847	Am4	Aortic mass QTL 4		0.001	aorta mass (VT:0002845)	aorta weight to aorta length to body weight ratio (CMO:0002722)	2	152413072	175950118	Rat
12879837	Am2	Aortic mass QTL 2		0.001	aorta mass (VT:0002845)	aorta weight to aorta length to body weight ratio (CMO:0002722)	2	152413072	185122374	Rat

Markers in Region

RH94508

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	2	157,506,068 - 157,506,194 (+)	MAPPER	mRatBN7.2
Rnor_6.0	2	170,220,969 - 170,221,094	NCBI	Rnor6.0
Rnor_5.0	2	189,563,320 - 189,563,445	UniSTS	Rnor5.0
RGSC_v3.4	2	163,521,150 - 163,521,275	UniSTS	RGSC3.4
Celera	2	151,765,120 - 151,765,245	UniSTS
RH 3.4 Map	2	1027.6	UniSTS
Cytogenetic Map	2	q32	UniSTS

Expression

RNA-SEQ Expression

High: > 1000 TPM value Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM Below Cutoff: < 0.5 TPM

	alimentary part of gastrointestinal system	circulatory system	endocrine system	exocrine system	hemolymphoid system	hepatobiliary system	nervous system	reproductive system	respiratory system
High
Medium	2
Low							8
Below cutoff	1	18	3	1	2	1	32	2	1

View RNA-SEQ Expression Data

Sequence

Nucleotide Sequences


RefSeq Transcripts	NM_001389226	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	NM_013061	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	JACYVU010000069	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	L25926	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	M62889	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	X15546	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

RefSeq Acc Id:

ENSRNOT00000046681 ⟹ ENSRNOP00000045106

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2 Ensembl	2	157,506,342 - 157,585,260 (-)	Ensembl
Rnor_6.0 Ensembl	2	170,221,245 - 170,300,408 (-)	Ensembl

RefSeq Acc Id:

ENSRNOT00000088131 ⟹ ENSRNOP00000072960

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2 Ensembl	2	157,506,342 - 157,585,260 (-)	Ensembl
Rnor_6.0 Ensembl	2	170,240,644 - 170,301,348 (-)	Ensembl

RefSeq Acc Id:

NM_001389226 ⟹ NP_001376155

RefSeq Status:

VALIDATED

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2	2	157,505,893 - 157,586,228 (-)	NCBI

Protein Sequences


Protein RefSeqs	NP_001376155	(Get FASTA)	NCBI Sequence Viewer
GenBank Protein	AAA42144	(Get FASTA)	NCBI Sequence Viewer
	AAA65097	(Get FASTA)	NCBI Sequence Viewer
	CAA33552	(Get FASTA)	NCBI Sequence Viewer
	P23739	(Get FASTA)	NCBI Sequence Viewer

RefSeq Acc Id:

ENSRNOP00000045106 ⟸ ENSRNOT00000046681

RefSeq Acc Id:

ENSRNOP00000072960 ⟸ ENSRNOT00000088131

RefSeq Acc Id:	NP_001376155 ⟸ NM_001389226
- UniProtKB:	F1M792 (UniProtKB/TrEMBL)

Protein Domains

P-type

Protein Structures

Name	Modeler	Protein Id	AA Range	Protein Structure
AF-P23739-F1-model_v2	AlphaFold	P23739	1-1841	view protein structure

Transcriptome

eQTL		View at Phenogen
WGCNA		View at Phenogen
Tissue/Strain Expression		View at Phenogen

Additional Information

External Database Links

Database	Acc Id	Source(s)
AGR Gene	RGD:3675	AgrOrtholog
BioCyc Gene	G2FUF-52801	BioCyc
Ensembl Genes	ENSRNOG00000031067	Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Protein	ENSRNOP00000045106	ENTREZGENE
	ENSRNOP00000045106.5	UniProtKB/TrEMBL
	ENSRNOP00000072960.2	UniProtKB/TrEMBL
Ensembl Transcript	ENSRNOT00000046681	ENTREZGENE
	ENSRNOT00000046681.5	UniProtKB/TrEMBL
	ENSRNOT00000088131.2	UniProtKB/TrEMBL
Gene3D-CATH	2.60.40.1180	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	4.10.110.10	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	Glycosidases	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	glycosyl hydrolase (family 31)	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro	Gal_mutarotase_N	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	Gal_mutarotase_sf_dom	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	Glyco_hydro_31	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	Glyco_hydro_31_AS	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	Glyco_hydro_31_CS	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	Glyco_hydro_31_N_dom	UniProtKB/TrEMBL
	Glyco_hydro_b	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	Glycoside_hydrolase_SF	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	P_trefoil_CS	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	P_trefoil_dom	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	P_trefoil_dom_sf	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
NCBI Gene	497756	ENTREZGENE
PANTHER	ALPHA-GLUCOSIDASE	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	P-TYPE DOMAIN-CONTAINING PROTEIN	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	SUCRASE-ISOMALTASE, INTESTINAL	UniProtKB/TrEMBL
Pfam	Gal_mutarotas_2	UniProtKB/TrEMBL
	Glyco_hydro_31	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	NtCtMGAM_N	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	Trefoil	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen	Si	PhenoGen
PROSITE	GLYCOSYL_HYDROL_F31_1	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	GLYCOSYL_HYDROL_F31_2	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	P_TREFOIL_1	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	P_TREFOIL_2	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
SMART	SM00018	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP	Glycosyl hydrolase domain	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	SSF51445	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	SSF57492	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	SSF74650	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt	A0A0G2K499_RAT	UniProtKB/TrEMBL
	F1M792	ENTREZGENE, UniProtKB/TrEMBL
	P23739	ENTREZGENE, UniProtKB/Swiss-Prot

Nomenclature History

Date	Current Symbol	Current Name	Previous Symbol	Previous Name	Description	Reference	Status
2016-04-13	Si	sucrase-isomaltase	Si	sucrase-isomaltase (alpha-glucosidase)	Nomenclature updated to reflect human and mouse nomenclature	1299863	APPROVED
2008-02-15	Si	sucrase-isomaltase (alpha-glucosidase)	Si	Sucrase-isomaltase	Nomenclature updated to reflect human and mouse nomenclature	1299863	APPROVED
2002-06-10	Si	Sucrase-isomaltase			Symbol and Name status set to approved	70586	APPROVED

RGD Curation Notes

Note Type	Note	Reference
gene_cellular_localization	sorted to apical pole of cell	70229
gene_expression	expressed in intestine	70229

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

Imported Disease Annotations - ClinVar

Imported Disease Annotations - CTD

Imported Disease Annotations - OMIM

Imported Annotations - SMPDB

Imported Annotations - KEGG (archival)

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Imported Disease Annotations - ClinVar

Imported Disease Annotations - CTD

Imported Disease Annotations - OMIM

Imported Annotations - SMPDB

Imported Annotations - KEGG (archival)