Ccl2 (C-C motif chemokine ligand 2) - Rat Genome Database

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Gene: Ccl2 (C-C motif chemokine ligand 2) Rattus norvegicus
Symbol: Ccl2
Name: C-C motif chemokine ligand 2
RGD ID: 3645
Description: Enables chemokine activity and heparin binding activity. Involved in several processes, including cellular response to cytokine stimulus; cellular response to lipid; and leukocyte chemotaxis. Located in several cellular components, including endocytic vesicle; perikaryon; and perinuclear region of cytoplasm. Colocalizes with C-fiber. Used to study several diseases, including artery disease (multiple); diabetic angiopathy; interstitial lung disease (multiple); kidney disease (multiple); and pancreatitis (multiple). Biomarker of several diseases, including artery disease (multiple); cerebrovascular disease (multiple); liver disease (multiple); lung disease (multiple); and pancreatitis (multiple). Human ortholog(s) of this gene implicated in several diseases, including Henoch-Schoenlein purpura; aggressive periodontitis; autoimmune disease (multiple); end stage renal disease; and gastrointestinal system cancer (multiple). Orthologous to human CCL2 (C-C motif chemokine ligand 2); PARTICIPATES IN angiotensin II signaling pathway; vascular endothelial growth factor signaling pathway; granulocyte-macrophage colony-stimulating factor signaling pathway; INTERACTS WITH (+)-pilocarpine; (+)-schisandrin B; (R,R,R)-alpha-tocopherol.
Type: protein-coding
Previously known as: C-C motif chemokine 2; chemokine (C-C motif) ligand 2; immediate-early serum-responsive JE protein; immediate-early serum-responsive protein JE; MCP-1; monocyte chemoattractant protein 1; monocyte chemoattractant protein-1; monocyte chemotactic protein 1; Scya2; Sigje; small inducible cytokine A2; Small inducible gene JE; small-inducible cytokine A2
RGD Orthologs
Green Monkey
Alliance Genes
More Info more info ...
Candidate Gene For: Eau3 Eae18b Eau9 Bp374
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Rat AssemblyChrPosition (strand)SourceGenome Browsers
GRCr81067,503,077 - 67,504,875 (+)NCBIGRCr8
mRatBN7.21067,005,424 - 67,007,222 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1067,005,424 - 67,007,226 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1071,626,649 - 71,628,447 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01071,131,996 - 71,133,794 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01066,593,121 - 66,594,919 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01069,412,065 - 69,413,863 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1069,412,017 - 69,413,870 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01069,047,091 - 69,048,889 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41070,256,263 - 70,258,061 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera1065,952,968 - 65,954,766 (+)NCBICelera
Cytogenetic Map10q26NCBI
JBrowse: View Region in Genome Browser (JBrowse)