Ccl2 (C-C motif chemokine ligand 2) - Rat Genome Database

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Gene: Ccl2 (C-C motif chemokine ligand 2) Rattus norvegicus
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Symbol: Ccl2
Name: C-C motif chemokine ligand 2
RGD ID: 3645
Description: Enables chemokine activity and heparin binding activity. Involved in several processes, including cellular response to cytokine stimulus; leukocyte chemotaxis; and positive regulation of leukocyte migration. Located in several cellular components, including axon; perikaryon; and perinuclear region of cytoplasm. Used to study several diseases, including artery disease (multiple); diabetic angiopathy; interstitial lung disease (multiple); kidney disease (multiple); and pancreatitis (multiple). Biomarker of several diseases, including artery disease (multiple); cerebrovascular disease (multiple); liver disease (multiple); lung disease (multiple); and pancreatitis (multiple). Human ortholog(s) of this gene implicated in several diseases, including IgA vasculitis; aggressive periodontitis; autoimmune disease (multiple); end stage renal disease; and gastrointestinal system cancer (multiple). Orthologous to human CCL2 (C-C motif chemokine ligand 2); PARTICIPATES IN angiotensin II signaling pathway; vascular endothelial growth factor signaling pathway; granulocyte-macrophage colony-stimulating factor signaling pathway; INTERACTS WITH (+)-pilocarpine; (+)-schisandrin B; (R,R,R)-alpha-tocopherol.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: C-C motif chemokine 2; chemokine (C-C motif) ligand 2; immediate-early serum-responsive JE protein; immediate-early serum-responsive protein JE; MCP-1; monocyte chemoattractant protein 1; monocyte chemoattractant protein-1; monocyte chemotactic protein 1; Scya2; Sigje; small inducible cytokine A2; Small inducible gene JE; small-inducible cytokine A2
RGD Orthologs
Human
Mouse
Bonobo
Dog
Pig
Green Monkey
Alliance Orthologs
More Info more info ...
Candidate Gene For: Eau3 Eae18b Eau9 Bp374
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81067,503,077 - 67,504,875 (+)NCBIGRCr8
mRatBN7.21067,005,424 - 67,007,222 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1067,005,424 - 67,007,226 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1071,626,649 - 71,628,447 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01071,131,996 - 71,133,794 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01066,593,121 - 66,594,919 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01069,412,065 - 69,413,863 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1069,412,017 - 69,413,870 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01069,047,091 - 69,048,889 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41070,256,263 - 70,258,061 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera1065,952,968 - 65,954,766 (+)NCBICelera
Cytogenetic Map10q26NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View
abdominal aortic aneurysm  (IEP)
Acute Anterior Uveitis  (ISO)
Acute Liver Failure  (ISO)
Acute Lung Injury  (IEP)
acute myeloid leukemia  (ISO)
acute necrotizing pancreatitis  (IDA,IEP)
Acute-On-Chronic Liver Failure  (ISO)
adult respiratory distress syndrome  (ISO)
age related macular degeneration  (ISS)
aggressive periodontitis  (ISO)
alcoholic hepatitis  (ISO)
allergic conjunctivitis  (ISO)
allergic disease  (ISO)
anemia  (ISO)
Animal Hepatitis  (ISO)
anterior uveitis  (IEP,ISO)
anti-basement membrane glomerulonephritis  (IDA,IEP)
arteriosclerosis  (ISO)
asthma  (IEP,ISO)
atherosclerosis  (ISO)
autistic disorder  (ISO)
autoimmune hepatitis  (ISO)
Bacteremia  (ISO)
bacterial pneumonia  (ISO)
Behcet's disease  (ISO)
Binge Drinking  (IEP)
bipolar disorder  (ISO)
Brain Hypoxia-Ischemia  (IEP)
Brain Injuries  (IEP,IMP,ISO)
brain ischemia  (IEP,ISO)
Bronchial Hyperreactivity  (ISO)
bronchiolitis obliterans  (IMP)
calcinosis  (ISO)
cardiomyopathy  (IEP)
Cardiotoxicity  (ISO)
cardiovascular system disease  (ISO)
carotid artery disease  (ISO)
Carotid Artery Injuries  (IDA,ISO)
Carrington Syndrome  (ISO)
cerebral infarction  (ISO)
Chagas disease  (IEP)
Chemical and Drug Induced Liver Injury  (ISO)
cholangitis  (IEP)
Choroidal Neovascularization  (ISO)
Chronic Hepatitis B  (ISO)
Chronic Hepatitis C  (ISO)
Chronic Intermittent Hypoxia  (IEP)
chronic obstructive pulmonary disease  (ISO)
Chronic Periodontitis  (ISO)
Chronic Relapsing Experimental Autoimmune Encephalomyelitis  (IEP)
Chronic Tubulointerstitial Nephropathy  (IEP)
colitis  (IEP)
colon cancer  (IEP)
Colonic Neoplasms  (ISO)
congenital diaphragmatic hernia  (ISO)
congestive heart failure  (IEP,ISO)
contact dermatitis  (ISO)
Contusions  (IEP)
coronary artery disease  (IEP,ISO)
Coronary Artery Disease, Development of, in HIV  (ISO)
Coronavirus infectious disease  (ISO)
COVID-19  (ISO)
crescentic glomerulonephritis  (IDA,IMP)
Crohn's disease  (ISO)
cryptococcosis  (ISO)
cutaneous leishmaniasis  (ISO)
cystic fibrosis  (ISO)
Delayed Hypersensitivity  (IEP)
diabetic angiopathy  (IDA)
Diabetic Nephropathies  (IEP,ISO)
diabetic retinopathy  (IEP)
Drug-Related Side Effects and Adverse Reactions  (ISO)
Duchenne muscular dystrophy  (ISO)
end stage renal disease  (IDA,IEP,ISO)
Endometrial Neoplasms  (ISO)
endometriosis  (ISO)
endomyocardial fibrosis  (IEP)
Endotoxemia  (IEP)
Endotoxin-Induced Uveitis  (IDA)
Experimental Arthritis  (IDA,IEP,IMP)
Experimental Autoimmune Encephalomyelitis  (IEP)
Experimental Autoimmune Myocarditis  (IEP)
Experimental Autoimmune Orchitis  (IEP)
Experimental Autoimmune Uveitis  (IEP)
Experimental Autoimmune Uveoretinitis  (ISO)
Experimental Diabetes Mellitus  (IDA,IEP)
Experimental Liver Cirrhosis  (IEP,ISO)
Eye Neoplasms  (ISO)
familial hyperlipidemia  (ISO)
Febrile Neutropenia  (ISO)
fibromyalgia  (ISO)
fungal infectious disease  (ISO)
gastritis  (IDA)
Geographic Atrophy  (ISO)
gestational diabetes  (ISO)
gliosarcoma  (ISO)
glomerulonephritis  (ISO)
Granulomatous Interstitial Nephritis  (IEP)
Granulomatous Vasculitis  (IMP)
Graves ophthalmopathy  (ISO)
Guillain-Barre syndrome  (ISO)
Hearing Loss, Noise-Induced  (ISO)
heart valve disease  (ISO)
hemarthrosis  (ISO)
hemolytic-uremic syndrome  (IEP)
hepatic encephalopathy  (IEP)
hepatocellular carcinoma  (ISO)
herpes simplex  (ISO)
herpes simplex virus keratitis  (ISO)
human immunodeficiency virus infectious disease  (ISO)
Human Influenza  (ISO)
Hyperalgesia  (IDA,IEP,IMP,ISO)
hyperglycemia  (ISO)
hyperhomocysteinemia  (IEP)
hyperinsulinism  (IEP,ISO)
Hyperoxaluria  (ISO)
hypertension  (IDA,IEP,ISO)
Hypoxia  (IEP)
IgA glomerulonephritis  (IEP)
IgA vasculitis  (ISO)
Inflammation  (IEP,ISO)
Inflammatory Breast Neoplasms  (ISO)
influenza  (ISO)
Insulin Resistance  (ISO)
interstitial lung disease  (IMP,ISO)
interstitial nephritis  (ISO)
Intestinal Reperfusion Injury  (IEP)
intracranial aneurysm  (IEP,IMP)
intracranial vasospasm  (IEP)
invasive aspergillosis  (ISO)
Invasive Pulmonary Aspergillosis  (IDA)
ischemia  (ISO)
kidney disease  (IMP)
Kidney Reperfusion Injury  (IDA,ISO)
Kuhnt-Junius degeneration  (ISO)
limited scleroderma  (ISO)
lipodystrophy  (ISO)
liver cirrhosis  (IEP,ISO)
liver disease  (ISO)
Liver Metastasis  (ISO)
Liver Reperfusion Injury  (IEP,ISO)
Lower Extremity Deep Vein Thrombosis  (ISO)
lung disease  (IEP)
Lung Injury  (ISO)
lupus nephritis  (ISO)
Lyme Neuroborreliosis  (ISO)
macular degeneration  (ISO)
macular retinal edema  (ISO)
membranoproliferative glomerulonephritis  (IMP)
metabolic dysfunction and alcohol associated liver disease  (ISO)
metabolic dysfunction-associated steatohepatitis  (IEP,ISO)
metabolic dysfunction-associated steatotic liver disease  (IEP,ISO)
Metabolic Syndrome  (ISO)
middle cerebral artery infarction  (ISO)
Middle East respiratory syndrome  (ISO)
Mouth Neoplasms  (ISO)
multiple myeloma  (ISO)
Multiple Organ Failure  (IEP)
multiple sclerosis  (ISO)
myocardial infarction  (IDA,IEP,ISO)
Myocardial Ischemia  (IEP,ISO)
Myocardial Reperfusion Injury  (IEP,ISO)
myocarditis  (ISO)
Nasal Polyps  (ISO)
Neoplasm Invasiveness  (ISO)
Neoplasm Metastasis  (ISO)
nephritis  (ISO)
neural tube defect  (ISO)
Neurodevelopmental Disorders  (ISO)
obesity  (IEP,ISO)
obstructive jaundice  (IDA)
obstructive sleep apnea  (ISO)
oral squamous cell carcinoma  (IEP,ISO)
orchitis  (IEP)
Oxygen-Induced Retinopathy  (IDA,ISO)
Pain  (IDA)
Painful Neuropathy  (IEP,ISO)
pancreatitis  (IEP,IMP,ISO)
Perennial Allergic Rhinitis  (ISO)
Peri-Implantitis  (ISO)
periapical periodontitis  (IEP)
Periodontal Cyst  (ISO)
periodontitis  (IEP)
Peripheral Nerve Injuries  (IEP)
Peritoneal Fibrosis  (ISO)
Plaque, Atherosclerotic  (ISO)
pleural disease  (ISO)
pneumocystosis  (ISO)
pneumonia  (ISO)
portal hypertension  (ISO)
Premature Obstetric Labor  (ISO)
proliferative diabetic retinopathy  (ISO)
Pulmonary Contusion  (IEP)
pulmonary edema  (IEP)
pulmonary embolism  (IEP)
pulmonary emphysema  (ISO)
pulmonary fibrosis  (IEP,ISO)
pulmonary hypertension  (IEP,ISO)
pulmonary tuberculosis  (ISO)
Reperfusion Injury  (IDA,ISO)
Respiratory Tract Granuloma  (IDA,ISO)
Retina Reperfusion Injury  (IDA)
retinal degeneration  (ISO)
retinal detachment  (ISO)
retinitis  (ISO)
rheumatoid arthritis  (ISO)
sarcoma  (IEP)
schizophrenia  (ISO)
sciatic neuropathy  (IEP,ISO)
Sepsis  (IEP)
severe acute respiratory syndrome  (ISO)
silicosis  (ISO)
skin melanoma  (ISO)
spina bifida  (ISO)
Spinal Cord Compression  (IEP,ISO)
squamous cell carcinoma  (ISO)
status epilepticus  (IEP,ISO)
steatotic liver disease  (ISO)
Stroke  (IEP,ISO)
systemic lupus erythematosus  (ISO)
systemic scleroderma  (ISO)
temporal arteritis  (ISO)
thrombocytopenia  (ISO)
thyroid gland disease  (ISO)
Thyroid Neoplasms  (ISO)
toxic shock syndrome  (ISO)
transient cerebral ischemia  (IDA,IEP)
Transplant Rejection  (ISO)
Triple Negative Breast Neoplasms  (ISO)
tuberculosis  (ISO)
type 1 diabetes mellitus  (ISO)
type 2 diabetes mellitus  (IEP)
ureteral obstruction  (ISO)
uveitis  (IEP,ISO)
Vasculitis of the Skin  (ISO)
Venous Thrombosis  (IEP)
viral pneumonia  (ISO)

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-abscisic acid  (ISO)
(+)-catechin  (ISO)
(+)-pilocarpine  (EXP,ISO)
(+)-schisandrin B  (EXP)
(-)-anisomycin  (ISO)
(-)-Arctigenin  (ISO)
(-)-demecolcine  (ISO)
(-)-epigallocatechin 3-gallate  (ISO)
(24S)-24-hydroxycholesterol  (ISO)
(25R)-cholest-5-ene-3beta,26-diol  (ISO)
(2R,4R)-1-[(2S)-5-(diaminomethylideneamino)-2-[(3-methyl-1,2,3,4-tetrahydroquinolin-8-yl)sulfonylamino]-1-oxopentyl]-4-methyl-2-piperidinecarboxylic acid  (ISO)
(4Z,7Z,10Z,13Z,15E,19Z)-17-hydroxydocosahexaenoic acid  (ISO)
(E)-thiamethoxam  (ISO)
(R)-lipoic acid  (ISO)
(R,R,R)-alpha-tocopherol  (EXP,ISO)
(S)-colchicine  (EXP)
(S)-nicotine  (EXP,ISO)
1,1,1-Trichloro-2-(o-chlorophenyl)-2-(p-chlorophenyl)ethane  (ISO)
1,2,4-trichloro-5-(2,5-dichlorophenyl)benzene  (EXP,ISO)
1,2,4-trimethylbenzene  (EXP)
1,2-dimethylhydrazine  (ISO)
1,3,5-trimethylbenzene  (ISO)
1,3-benzothiazole-2-thiol  (ISO)
1,4-benzoquinone  (ISO)
1,4-naphthoquinone  (ISO)
1,4-phenylenediamine  (ISO)
1-[2-(3,4-dichlorophenyl)ethyl]-4-methylpiperazine  (ISO)
1-chloro-2,4-dinitrobenzene  (ISO)
1-fluoro-2,4-dinitrobenzene  (ISO)
1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine  (ISO)
1-naphthyl isothiocyanate  (EXP,ISO)
11-deoxycorticosterone  (EXP)
13-HPODE  (EXP)
14-Deoxy-11,12-didehydroandrographolide  (ISO)
15-acetyldeoxynivalenol  (ISO)
15-deoxy-Delta(12,14)-prostaglandin J2  (ISO)
17alpha-ethynylestradiol  (EXP,ISO)
17beta-estradiol  (EXP,ISO)
17beta-estradiol 3-benzoate  (EXP)
17beta-hydroxy-5alpha-androstan-3-one  (ISO)
2,2',4,4',5,5'-hexachlorobiphenyl  (EXP,ISO)
2,2',4,4'-Tetrabromodiphenyl ether  (EXP,ISO)
2,2',5,5'-tetrachlorobiphenyl  (ISO)
2,3',4,4',5-Pentachlorobiphenyl  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,4,4'-trichlorobiphenyl  (ISO)
2,4,6-trinitrobenzenesulfonic acid  (EXP,ISO)
2,4,6-trinitrotoluene  (EXP)
2,4-D  (EXP,ISO)
2,4-diaminotoluene  (ISO)
2,4-dibromophenyl 2,4,5-tribromophenyl ether  (ISO)
2,6-di-tert-butyl-4-methylphenol  (ISO)
2-acetamidofluorene  (EXP)
2-acetyl-1-alkyl-sn-glycero-3-phosphocholine  (ISO)
2-amino-2-deoxy-D-galactopyranose  (ISO)
2-amino-2-deoxy-D-glucopyranose  (EXP,ISO)
2-aminopurine  (ISO)
2-arachidonoylglycerol  (ISO)
2-butoxyethanol  (ISO)
2-hydroxypropanoic acid  (ISO)
2-tert-butylhydroquinone  (ISO)
22-Hydroxycholesterol  (ISO)
24,25-Dihydroxyvitamin D  (ISO)
26-hydroxycholesterol  (ISO)
3'-amino-3'-deoxy-N(6),N(6)-dimethyladenosine  (EXP)
3,3',4,4',5-pentachlorobiphenyl  (EXP,ISO)
3,3',4,4'-tetrachlorobiphenyl  (ISO)
3,4-dihydroxybenzoic acid  (ISO)
3-(1H-indol-3-yl)propanoic acid  (ISO)
3-[3-(tert-butylsulfanyl)-1-(4-chlorobenzyl)-5-(propan-2-yl)-1H-indol-2-yl]-2,2-dimethylpropanoic acid  (EXP)
3-acetyldeoxynivalenol  (ISO)
3-chloropropane-1,2-diol  (EXP)
3-isobutyl-1-methyl-7H-xanthine  (ISO)
3-methylcholanthrene  (ISO)
3H-1,2-dithiole-3-thione  (EXP)
4',5,7-Trimethoxyflavone  (ISO)
4'-hydroxydiclofenac  (ISO)
4'-Methoxychalcone  (ISO)
4,4'-diaminodiphenylmethane  (ISO)
4,4'-sulfonyldiphenol  (ISO)
4-(ethoxymethylene)-2-phenyloxazol-5-one  (ISO)
4-(N-nitrosomethylamino)-1-(3-pyridyl)butan-1-one  (ISO)
4-Hydroxybenzophenone  (ISO)
4-hydroxynon-2-enal  (ISO)
4-hydroxyphenyl retinamide  (ISO)
4-methylhistamine  (ISO)
4-nitro-m-cresol  (ISO)
4-nitroquinoline N-oxide  (ISO)
4-phenylbutyric acid  (ISO)
5'-S-methyl-5'-thioadenosine  (ISO)
5-fluorouracil  (ISO)
6-propyl-2-thiouracil  (EXP,ISO)
7,12-dimethyltetraphene  (ISO)
7,9-dihydro-1H-purine-2,6,8(3H)-trione  (EXP,ISO)
7-ketocholesterol  (ISO)
7alpha-hydroxycholesterol  (ISO)
8-Br-cAMP  (EXP,ISO)
9-cis-retinoic acid  (ISO)
9-hydroxycanthin-6-one  (ISO)
Abemaciclib  (ISO)
acarbose  (EXP)
acetaldehyde  (ISO)
acetamide  (EXP)
acetic acid [2-[[(5-nitro-2-thiazolyl)amino]-oxomethyl]phenyl] ester  (ISO)
acetoacetic acid  (ISO)
acetylsalicylic acid  (EXP,ISO)
acrolein  (EXP,ISO)
acrylic acid  (EXP)
acrylonitrile  (EXP,ISO)
acteoside  (ISO)
actinomycin D  (ISO)
acyclovir  (ISO)
adenine  (ISO)
Adenosine, cyclic 3',5'-[hydrogen [p(s)]-phosphorothioate]  (ISO)
Aeol 10150  (ISO)
aflatoxin B1  (EXP,ISO)
Aflatoxin G1  (ISO)
AICA ribonucleotide  (EXP,ISO)
albendazole  (ISO)
alclometasone dipropionate  (ISO)
aldehydo-D-glucosamine  (EXP,ISO)
aldehydo-D-glucose  (EXP,ISO)
alexidine  (ISO)
all-trans-retinoic acid  (EXP,ISO)
all-trans-retinol  (EXP,ISO)
allopurinol  (EXP,ISO)
alloxan  (ISO)
alloxanthine  (ISO)
allyl alcohol  (ISO)
allyl methyl disulfide  (ISO)
alpha-hexylcinnamaldehyde  (ISO)
alpha-linolenic acid  (EXP)
alpha-naphthoflavone  (ISO)
aluminium hydroxide  (ISO)
aluminium oxide  (ISO)
AM6545  (ISO)
ambroxol  (EXP)
amiloride  (EXP,ISO)
amiodarone  (ISO)
amitrole  (ISO)
amlexanox  (ISO)
amlodipine  (EXP)
ammonium chloride  (EXP)
amprenavir  (ISO)
anagliptin  (ISO)
andrographolide  (ISO)
Anemoside B4  (ISO)
angiotensin II  (ISO)
anthocyanin  (ISO)
anthra[1,9-cd]pyrazol-6(2H)-one  (EXP,ISO)
antimony(0)  (ISO)
antimycin A  (ISO)
antirheumatic drug  (ISO)
apigenin  (ISO)
apocynin  (ISO)
Archazolid B  (ISO)
argatroban  (ISO)
aripiprazole  (ISO)
aristolochic acid A  (EXP)
aristolochic acids  (ISO)
Aroclor 1254  (ISO)
arsane  (ISO)
arsenic atom  (ISO)
arsenite(3-)  (ISO)
arsenous acid  (EXP,ISO)
asbestos  (ISO)
aspalathin  (ISO)
aspartame  (ISO)
astressin 2B  (ISO)
atazanavir sulfate  (ISO)
atorvastatin calcium  (EXP,ISO)
atrazine  (EXP)
aurantio-obtusin  (ISO)
azathioprine  (ISO)
azithromycin  (ISO)
Azoxymethane  (ISO)
Bardoxolone methyl  (ISO)
baricitinib  (ISO)
barium sulfate  (EXP)
bathocuproine disulfonic acid  (ISO)
beclomethasone  (ISO)
benazepril  (EXP)
benzalkonium chloride  (ISO)
benzene  (EXP,ISO)
benzene-1,2,4-triol  (ISO)
benzethonium chloride  (ISO)
benzo[a]pyrene  (ISO)
benzo[a]pyrene diol epoxide I  (ISO)
benzofurans  (ISO)
benzoic acid  (ISO)
benzylpenicillin  (ISO)
berberine  (ISO)
Bergenin  (ISO)
beta-D-glucan  (ISO)
beta-D-glucosamine  (EXP,ISO)
beta-naphthoflavone  (EXP,ISO)
betamethasone  (ISO)
bezafibrate  (ISO)
bicalutamide  (ISO)
bis(2-chloroethyl) sulfide  (ISO)
bis(2-ethylhexyl) phthalate  (ISO)
bisoprolol  (ISO)
bisphenol A  (EXP,ISO)
Bisphenol A diglycidyl ether  (ISO)
bisphenol AF  (ISO)
Bisphenol B  (ISO)
bisphenol F  (ISO)
bleomycin A2  (EXP,ISO)
boron nitride  (ISO)
bortezomib  (ISO)
BQ 123  (ISO)
Brevianamide A  (ISO)
bromodichloromethane  (ISO)
Bucillamine  (ISO)
budesonide  (EXP,ISO)
butanal  (ISO)
Butylbenzyl phthalate  (ISO)
butyric acid  (EXP,ISO)
C60 fullerene  (EXP)
cadmium atom  (EXP,ISO)
cadmium dichloride  (EXP,ISO)
cadmium selenide  (ISO)
Calcimycin  (ISO)
calcitriol  (ISO)
calcium atom  (ISO)
calcium dichloride  (ISO)
calcium oxalate  (EXP)
calcium silicate  (EXP)
calcium(0)  (ISO)
Calphostin C  (ISO)
camostat  (EXP)
camptothecin  (ISO)
cannabidiol  (ISO)
capsaicin  (EXP,ISO)
capsazepine  (ISO)
CARBENOXOLONE  (ISO)
carbon nanotube  (EXP,ISO)
carbonyl sulfide  (EXP)
carmustine  (ISO)
carnosine  (ISO)
carrageenan  (ISO)
catechol  (ISO)
celecoxib  (EXP,ISO)
cephaeline  (ISO)
ceric oxide  (EXP,ISO)
cerivastatin  (ISO)
ceruletide  (ISO)
CGP 52608  (ISO)
chenodeoxycholic acid  (ISO)
chlorambucil  (ISO)
chlornitrofen  (EXP)
chlorobenzene  (ISO)
chloroethene  (ISO)
chloroform  (ISO)
chlorogenic acid  (ISO)
chloroquine  (ISO)
chlorothalonil  (ISO)
chlorpyrifos  (EXP)
cholesterol  (EXP,ISO)
choline  (EXP,ISO)
chondroitin sulfate  (ISO)
chromium(3+) trichloride  (ISO)
chromium(6+)  (ISO)
chrysin 5,7-dimethyl ether  (ISO)
ciguatoxin CTX1B  (ISO)
cilostazol  (ISO)
cimetidine  (ISO)
cis-caffeic acid  (ISO)
cisplatin  (EXP,ISO)
citric acid  (ISO)
clobenpropit  (ISO)
clofibrate  (ISO)
clonidine  (ISO)
clonidine (amino form)  (ISO)
clonidine (imino form)  (ISO)
cobalt atom  (ISO)
cobalt dichloride  (EXP,ISO)
cocaine  (EXP,ISO)
codeine  (ISO)
compound 48/80  (ISO)
copper atom  (EXP,ISO)
copper(0)  (EXP,ISO)
copper(II) sulfate  (ISO)
cordycepin  (ISO)
corticosterone  (EXP,ISO)
cortisol  (EXP,ISO)
cortisone  (ISO)
coumermycin A1  (ISO)
crocidolite asbestos  (EXP,ISO)
crotonaldehyde  (ISO)
CU-O LINKAGE  (ISO)
cucurbitacin B  (ISO)
Cuprizon  (EXP)
curcumin  (EXP,ISO)
cyanocob(III)alamin  (EXP)
cycloheximide  (ISO)
cyclophosphamide  (EXP,ISO)
cyclosporin A  (EXP,ISO)
cyhalothrin  (EXP)
D-glucose  (EXP,ISO)
dantrolene  (EXP)
dapagliflozin  (EXP)
daunorubicin  (ISO)
DDE  (ISO)
Decursin  (ISO)
deferiprone  (EXP,ISO)
deguelin  (EXP)
deoxycholic acid  (ISO)
Deoxycorticosterone acetate  (EXP)
deoxynivalenol  (ISO)
dequalinium  (ISO)
desferrioxamine B  (EXP)
dexamethasone  (EXP,ISO)
dexmedetomidine  (ISO)
dextran sulfate  (ISO)
dextromethorphan  (ISO)
diallyl disulfide  (ISO)
diallyl trisulfide  (ISO)
diarsenic trioxide  (EXP,ISO)
dibenziodolium  (ISO)
dibutyl phthalate  (EXP,ISO)
dichlorine  (ISO)
dichloroacetic acid  (ISO)
dichromium trioxide  (ISO)
diclofenac  (EXP,ISO)
Didecyldimethylammonium  (ISO)
dienogest  (ISO)
diethyl phthalate  (ISO)
diethylstilbestrol  (EXP,ISO)
digitoxigenin  (ISO)
digitoxin  (ISO)
digoxigenin  (ISO)
digoxin  (ISO)
diisobutyl phthalate  (ISO)
diisononyl phthalate  (ISO)
diisopropyl fluorophosphate  (EXP,ISO)
dimemorfan  (EXP,ISO)
dimethoate  (ISO)
dimethyl fumarate  (ISO)
dimethyl sulfoxide  (EXP,ISO)
dimethyl-(phenylmethyl)-[2-[2-[4-(2,4,4-trimethylpentan-2-yl)phenoxy]ethoxy]ethyl]ammonium  (ISO)
dimethylarsinous acid  (ISO)
diminazene diaceturate  (ISO)
dinitrogen  (ISO)
diosgenin  (ISO)
dioxygen  (EXP,ISO)
diphenyl diselenide  (EXP)
diprotium oxide  (EXP,ISO)
dipyridamole  (EXP,ISO)
disulfiram  (ISO)
dobutamine  (ISO)
dorsomorphin  (ISO)
doxorubicin  (EXP,ISO)
edaravone  (EXP,ISO)
efavirenz  (ISO)
elemental selenium  (ISO)
ellagic acid  (ISO)
emetine  (ISO)
enalapril  (EXP,ISO)
endosulfan  (EXP)
entinostat  (ISO)
enzacamene  (ISO)
ergosta-4,6,8(14),22-tetraen-3-one  (ISO)
ergosterol  (EXP)
eriodictyol  (ISO)
erlotinib hydrochloride  (ISO)
erythromycin A  (ISO)
esculetin  (ISO)
ethambutol  (EXP)
ethanol  (EXP,ISO)
ethionamide  (EXP)
Ethyl icosapentate  (ISO)
ethylene glycol  (EXP,ISO)
ethylisopropylamiloride  (ISO)
eugenol  (ISO)
eupatilin  (ISO)
euxanthone  (ISO)
fasudil  (ISO)
febuxostat  (ISO)
felodipine  (ISO)
fenbendazole  (ISO)
fenofibrate  (ISO)
fentanyl  (EXP)
fenvalerate  (ISO)
ferric oxide  (EXP,ISO)
ferroheme b  (ISO)
ferulic acid  (ISO)
Fidarestat  (ISO)
fingolimod hydrochloride  (ISO)
fipronil  (EXP)
flavokawain B  (ISO)
flavone  (ISO)
flavonoids  (EXP)
flucloxacillin  (ISO)
fludrocortisone  (ISO)
flumequine  (ISO)
fluoranthene  (ISO)
fluoxetine  (ISO)
Fluridone  (ISO)
flutamide  (EXP)
fluticasone  (ISO)
fluvastatin  (EXP)
folic acid  (EXP,ISO)
formaldehyde  (ISO)
fructose  (EXP,ISO)
fulvestrant  (ISO)
furan  (EXP)
Fusarenone X  (ISO)
gadodiamide hydrate  (EXP,ISO)
gadolinium trichloride  (EXP)
gallic acid  (EXP,ISO)
Garcinol  (ISO)
gefitinib  (ISO)
gemcitabine  (ISO)
gemfibrozil  (EXP)
genistein  (EXP,ISO)
gentamycin  (EXP,ISO)
Gingerenone A  (ISO)
glucagon  (ISO)
glucose  (EXP,ISO)
glutathione  (ISO)
glycerol  (ISO)
glycidol  (EXP)
glycine betaine  (EXP)
glycyrrhizinic acid  (ISO)
glyoxylic acid  (EXP)
glyphosate  (ISO)
gold atom  (ISO)
gold(0)  (ISO)
gossypol  (ISO)
graphene oxide  (ISO)
graphite  (EXP,ISO)
GW 4064  (ISO)
GW 501516  (ISO)
GW 7647  (ISO)
gypenoside LXXV  (ISO)
halothane  (EXP)
harmaline  (ISO)
heme b  (ISO)
hemin  (ISO)
heparin  (EXP)
hesperetin  (ISO)
Hexachloro-1,3-butadiene  (EXP)
hexadecanoic acid  (EXP,ISO)
Hexadimethrine bromide  (EXP)
histamine  (ISO)
homocysteine  (ISO)
Honokiol  (EXP)
HU-308  (ISO)
hydrochlorothiazide  (EXP)
hydrogen chloride  (EXP)
hydrogen peroxide  (ISO)
hydrogen sulfide  (ISO)
hydroquinone  (ISO)
hydroxamic acid  (EXP)
hydroxychloroquine  (ISO)
ibuprofen  (ISO)
icosanoid  (EXP)
Ile(5)-angiotensin II  (ISO)
imiquimod  (ISO)
indinavir  (ISO)
indometacin  (EXP,ISO)
indoxyl sulfate  (EXP,ISO)
iodixanol  (ISO)
iodoacetic acid  (ISO)
iohexol  (ISO)
ionomycin  (ISO)
irbesartan  (ISO)
iron atom  (EXP,ISO)
iron(0)  (EXP,ISO)
iron(III) citrate  (ISO)
Isoangustone A  (ISO)
isoeugenol  (ISO)
isoflurane  (EXP)
isoprenaline  (ISO)
isotretinoin  (EXP)
ivermectin  (ISO)
Jujuboside A  (ISO)
kaempferol  (EXP,ISO)
kaempferol 3-O-beta-D-glucoside  (ISO)
kainic acid  (EXP)
ketoconazole  (EXP,ISO)
L-arginine  (ISO)
L-ascorbic acid  (ISO)
L-methionine  (EXP,ISO)
lanatoside C  (ISO)
lead diacetate  (ISO)
lead(0)  (EXP)
Leonurine  (ISO)
leptomycin B  (ISO)
leukotriene B4  (ISO)
leukotriene C4  (ISO)
lidocaine  (ISO)
lignin  (ISO)
limonin  (ISO)
linoleic acid  (ISO)
linuron  (ISO)
lipoic acid  (ISO)
lipopolysaccharide  (EXP,ISO)
lipoteichoic acid  (EXP,ISO)
liquiritigenin  (EXP,ISO)
liquiritin  (EXP,ISO)
lithium chloride  (ISO)
loganin  (ISO)
loliolide  (ISO)
lopinavir  (ISO)
lorcaserin  (ISO)
losartan  (EXP,ISO)
luteolin  (ISO)
LY294002  (ISO)
m-xylene  (EXP,ISO)
manganese atom  (EXP)
manganese(0)  (EXP)
manganese(II) chloride  (EXP,ISO)
mangiferin  (ISO)
manidipine  (EXP)
mebendazole  (ISO)
Mecamylamine  (EXP)
mechlorethamine  (EXP)
meclocycline  (ISO)
medroxyprogesterone acetate  (EXP)
MeIQx  (ISO)
melamine  (ISO)
melatonin  (ISO)
mephedrone  (EXP)
mercury dichloride  (EXP,ISO)
metam  (ISO)
metformin  (EXP,ISO)
methadone  (EXP)
methapyrilene  (EXP)
methimazole  (EXP,ISO)
methionine sulfoximine  (ISO)
methotrexate  (EXP,ISO)
methoxyacetic acid  (EXP)
methoxychlor  (ISO)
methyl beta-cyclodextrin  (ISO)
methyl methacrylate  (ISO)
methyl salicylate  (ISO)
Methylbenzethonium chloride  (ISO)
methylglyoxal  (ISO)
methylmercury chloride  (ISO)
metyrapone  (EXP)
mevalonic acid  (ISO)
microcystin-LR  (ISO)
midazolam  (ISO)
mifepristone  (EXP)
minocycline  (ISO)
mitomycin C  (ISO)
MJN110  (ISO)
MK 571  (ISO)
mono(2-ethyl-5-oxohexyl) phthalate  (ISO)
mono(2-ethylhexyl) phthalate  (ISO)
monobenzyl phthalate  (ISO)
Monobutylphthalate  (ISO)
monocrotaline  (EXP)
monosodium L-glutamate  (ISO)
montelukast  (EXP,ISO)
morin  (EXP)
morphine  (EXP)
Morroniside  (ISO)
Muraglitazar  (EXP)
mycophenolic acid  (EXP)
mycotoxin  (ISO)
myricitrin  (ISO)
N(gamma)-nitro-L-arginine methyl ester  (EXP,ISO)
N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine  (ISO)
N,N-dimethylformamide  (ISO)
N,O-dimethyltyramine  (ISO)
N-[2-(4-bromocinnamylamino)ethyl]isoquinoline-5-sulfonamide  (ISO)
N-acetyl-L-cysteine  (EXP,ISO)
N-benzyloxycarbonyl-L-leucyl-L-leucyl-L-leucinal  (EXP,ISO)
N-ethyl-5'-carboxamidoadenosine  (ISO)
N-methyl-N-nitrosourea  (EXP,ISO)
N-nitrosodiethylamine  (EXP,ISO)
N-nitrosodimethylamine  (EXP)
N-tosyl-L-phenylalanyl chloromethyl ketone  (EXP,ISO)
naloxone  (ISO)
naphthalene  (ISO)
naphthalenes  (EXP)
naproxen  (EXP)
naringin  (EXP,ISO)
nebivolol  (ISO)
nelfinavir  (ISO)
neocuproine  (ISO)
neoechinulin A  (ISO)
nickel atom  (EXP,ISO)
nickel dichloride  (ISO)
nickel subsulfide  (ISO)
nickel sulfate  (ISO)
niclosamide  (EXP,ISO)
nicotinamide  (ISO)
nicotine  (EXP,ISO)
nicotinic acid  (EXP,ISO)
nimesulide  (EXP,ISO)
nitrofen  (EXP)
nitrogen dioxide  (ISO)
nitroprusside  (ISO)
Nivalenol  (ISO)
nocodazole  (ISO)
nonane  (EXP)
Nonidet P-40  (ISO)
Nonylphenol  (ISO)
notoginsenoside R1  (ISO)
NS-398  (ISO)
NSC 23766  (ISO)
obeticholic acid  (ISO)
octadecanoic acid  (ISO)
okadaic acid  (ISO)
olaparib  (ISO)
oroxylin A  (EXP)
ouabain  (EXP)
oxalic acid  (ISO)
oxaliplatin  (EXP)
oxybutynin  (ISO)
oxytetracycline  (ISO)
ozone  (EXP,ISO)
Pachymic acid  (ISO)
paclitaxel  (ISO)
palmatine  (ISO)
paracetamol  (EXP,ISO)
paraquat  (EXP,ISO)
paricalcitol  (EXP,ISO)
parthenolide  (EXP,ISO)
PCB138  (ISO)
PD 168393  (ISO)
PD123319  (EXP)
pemetrexed  (ISO)
pentachlorophenol  (ISO)
pentanal  (ISO)
Pentoxifylline  (EXP,ISO)
peptidoglycan  (ISO)
perfluorooctane-1-sulfonic acid  (ISO)
perfluorooctanoic acid  (EXP,ISO)
perindopril  (ISO)
permethrin  (ISO)
PF-956980  (ISO)
phenethyl caffeate  (ISO)
phenethyl isothiocyanate  (ISO)
phenformin  (EXP)
phenobarbital  (EXP)
phenol  (ISO)
phentermine  (ISO)
phenylephrine  (EXP)
phenytoin  (EXP)
phloretin  (EXP,ISO)
phlorizin  (ISO)
phorbol 13-acetate 12-myristate  (ISO)
phosphatidylcholine  (ISO)
phthalic anhydride  (ISO)
phylloquinone  (EXP)
physostigmine  (ISO)
phytoestrogen  (ISO)
picolinic acid  (ISO)
pioglitazone  (ISO)
piperidines  (ISO)
Pirarubicin  (EXP)
pirinixic acid  (ISO)
pitavastatin  (ISO)
pitavastatin(1-)  (ISO)
plumbagin  (EXP)
poly(I:C)  (EXP,ISO)
polymyxin B2  (ISO)
pomalidomide  (ISO)
potassium chromate  (ISO)
potassium dichromate  (ISO)
pravastatin  (ISO)
prednisolone  (ISO)
pregnenolone 16alpha-carbonitrile  (ISO)
probenecid  (EXP,ISO)
probucol  (ISO)
procyanidin B2  (EXP)
procyanidin B3  (ISO)
progesterone  (EXP,ISO)
propan-2-ol  (ISO)
propanal  (ISO)
propidium  (ISO)
Proscillaridin  (ISO)
prostaglandin E2  (ISO)
prostaglandin I2  (ISO)
psicose  (ISO)
puromycin  (ISO)
Pyridostigmine bromide  (ISO)
pyrrolidine dithiocarbamate  (EXP,ISO)
pyrvinium  (ISO)
quartz  (EXP,ISO)
quercetin  (EXP,ISO)
quercetin 3-O-beta-D-glucofuranoside  (EXP)
quercetin 3-O-beta-D-glucopyranoside  (EXP)
rac-lactic acid  (ISO)
raloxifene  (EXP,ISO)
ramipril  (ISO)
razoxane  (EXP)
reactive oxygen species  (EXP,ISO)
rebaudioside A  (ISO)
remdesivir  (ISO)
resolvin D1  (ISO)
resolvin D2  (ISO)
resveratrol  (EXP,ISO)
ribavirin  (ISO)
rifampicin  (EXP)
rimonabant  (EXP,ISO)
ritonavir  (ISO)
rofecoxib  (ISO)
roflumilast  (ISO)
rolipram  (EXP)
rosuvastatin calcium  (EXP)
rotenone  (EXP,ISO)
rucaparib  (ISO)
rutin  (EXP,ISO)
S-(1,2-dichlorovinyl)-L-cysteine  (ISO)
S-butyl-DL-homocysteine (S,R)-sulfoximine  (EXP,ISO)
salicylic acid  (EXP,ISO)
Salinomycin  (ISO)
Salmeterol xinafoate  (ISO)
salubrinal  (ISO)
Salvianolic acid A  (ISO)
sarin  (EXP)
saroglitazar  (ISO)
sarpogrelate  (ISO)
SB 203580  (EXP,ISO)
SB 431542  (ISO)
SCH772984  (EXP)
scoparone  (ISO)
selenium atom  (ISO)
serpentine asbestos  (EXP,ISO)
sevoflurane  (EXP)
silicon dioxide  (EXP,ISO)
silver atom  (ISO)
silver(0)  (ISO)
simvastatin  (EXP,ISO)
Sinomenine  (ISO)
sirtinol  (ISO)
SL-327  (EXP)
sodium arsenite  (EXP,ISO)
sodium atom  (EXP)
sodium chlorate  (ISO)
sodium chloride  (ISO)
sodium cholate  (EXP,ISO)
sodium dichromate  (ISO)
sodium dodecyl sulfate  (ISO)
sodium fluoride  (EXP)
sodium hypochlorite  (ISO)
Sodium oleate  (ISO)
sodium stibogluconate  (ISO)
SR 144528  (ISO)
stavudine  (ISO)
steviol  (ISO)
stevioside  (ISO)
streptozocin  (EXP,ISO)
styrene  (ISO)
succimer  (ISO)
sucrose  (ISO)
sulfaphenazole  (ISO)
sulfapyridine  (ISO)
sulfasalazine  (EXP)
sulforaphane  (ISO)
sulfur dioxide  (EXP)
sumatriptan  (EXP)
sunitinib  (ISO)
superoxide  (ISO)
tacrolimus hydrate  (EXP,ISO)
tagatose  (ISO)
tamoxifen  (EXP,ISO)
taurocholic acid  (ISO)
telmisartan  (EXP,ISO)
temozolomide  (ISO)
terameprocol  (ISO)
terbinafine  (ISO)
tert-butyl hydroperoxide  (ISO)
Tesaglitazar  (EXP)
testosterone  (EXP,ISO)
Tetrachlorobisphenol A  (ISO)
tetrachloromethane  (EXP,ISO)
Tetramethylthiourea  (ISO)
tetraphene  (ISO)
tetrathiomolybdate(2-)  (ISO)
thalidomide  (ISO)
thapsigargin  (EXP,ISO)
theophylline  (ISO)
thiamethoxam  (ISO)
thioacetamide  (EXP,ISO)
Tiopronin  (ISO)
Tiron  (ISO)
titanium atom  (EXP,ISO)
titanium dioxide  (EXP,ISO)
TMC-120A  (ISO)
tofacitinib  (ISO)
Tolmetin glucuronide  (ISO)
toluene  (ISO)
toluene 2,4-diisocyanate  (ISO)
topotecan  (EXP)
trans-caffeic acid  (ISO)
trans-isoeugenol  (ISO)
trans-piceid  (ISO)
tremolite asbestos  (ISO)
triamcinolone  (ISO)
tributylstannane  (ISO)
trichloroethene  (EXP,ISO)
triclosan  (ISO)
trimethyltin  (ISO)
triphenylstannane  (ISO)
Triptolide  (ISO)
triptonide  (ISO)
troglitazone  (EXP,ISO)
trovafloxacin  (ISO)
Tungsten carbide  (ISO)
tunicamycin  (ISO)
undecane  (EXP)
uranium atom  (EXP)
ursodeoxycholic acid  (ISO)
vadimezan  (ISO)
valproic acid  (ISO)
valsartan  (EXP,ISO)
vanadyl sulfate  (EXP,ISO)
vanillin  (ISO)
vemurafenib  (ISO)
venetoclax  (ISO)
verteporfin  (ISO)
vincaleukoblastine  (EXP)
vincristine  (EXP,ISO)
vitamin E  (ISO)
vorinostat  (ISO)
water  (EXP,ISO)
withaferin A  (ISO)
wortmannin  (ISO)
xanthohumol  (ISO)
XL147  (ISO)
Y-27632  (ISO)
zalcitabine  (EXP)
zidovudine  (ISO)
zileuton  (ISO)
zinc atom  (ISO)
zinc nitrate  (ISO)
zinc oxide  (EXP,ISO)
zinc protoporphyrin  (EXP,ISO)
zinc sulfate  (ISO)
zinc(0)  (ISO)
ziram  (ISO)
zoledronic acid  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
animal organ regeneration  (IEP)
antimicrobial humoral immune response mediated by antimicrobial peptide  (IBA)
astrocyte cell migration  (ISO)
cellular response to ATP  (IEP)
cellular response to dexamethasone stimulus  (IEP)
cellular response to estradiol stimulus  (IEP)
cellular response to fatty acid  (IEP)
cellular response to fibroblast growth factor stimulus  (ISO)
cellular response to glucose stimulus  (IEP)
cellular response to high density lipoprotein particle stimulus  (IEP)
cellular response to insulin stimulus  (IEP)
cellular response to interleukin-1  (IEA,IEP,ISO)
cellular response to interleukin-6  (IEP)
cellular response to lipopolysaccharide  (IEA,IEP,ISO)
cellular response to lipoprotein particle stimulus  (IEP)
cellular response to macrophage colony-stimulating factor stimulus  (IEP)
cellular response to platelet-derived growth factor stimulus  (IEP)
cellular response to retinoic acid  (IEP)
cellular response to tumor necrosis factor  (IEA,IEP,ISO)
cellular response to type II interferon  (IEA,IEP,ISO)
cellular response to xenobiotic stimulus  (IEP)
chemokine (C-C motif) ligand 2 signaling pathway  (IEA,ISO)
chemokine-mediated signaling pathway  (IBA,IMP)
chemokinesis  (TAS)
chemotaxis  (IEA)
chronic inflammatory response  (IEP)
cytokine-mediated signaling pathway  (IMP,ISO)
cytoskeleton organization  (ISO)
eosinophil chemotaxis  (IBA)
glial cell migration  (IMP)
helper T cell extravasation  (IEA,ISO)
immune response  (IEA)
inflammatory response  (IBA,IEA)
intracellular calcium ion homeostasis  (IDA)
leukocyte migration involved in inflammatory response  (IMP)
lymphocyte chemotaxis  (IDA)
macrophage chemotaxis  (IDA,ISO)
mammary gland involution  (IEP)
maternal process involved in female pregnancy  (IEP)
maternal process involved in parturition  (IEP)
monocyte chemotaxis  (ISO)
negative regulation of angiogenesis  (IEA,ISO)
negative regulation of G1/S transition of mitotic cell cycle  (ISO)
negative regulation of glial cell apoptotic process  (ISO)
negative regulation of natural killer cell chemotaxis  (ISO)
negative regulation of neuron apoptotic process  (ISO)
negative regulation of vascular endothelial cell proliferation  (ISO)
neutrophil chemotaxis  (IMP)
osteoclast differentiation  (HEP)
positive chemotaxis  (IEA)
positive regulation of apoptotic cell clearance  (IEA,ISO)
positive regulation of calcium ion import  (ISO)
positive regulation of cell adhesion  (IDA)
positive regulation of cell migration  (IBA)
positive regulation of cell-cell adhesion  (IDA)
positive regulation of cellular extravasation  (IDA)
positive regulation of collagen biosynthetic process  (IDA)
positive regulation of endothelial cell apoptotic process  (ISO)
positive regulation of endothelial cell proliferation  (IMP)
positive regulation of gene expression  (IEA,ISO)
positive regulation of glutamate receptor signaling pathway  (IGI)
positive regulation of immune complex clearance by monocytes and macrophages  (IEA,ISO)
positive regulation of leukocyte mediated cytotoxicity  (IMP)
positive regulation of leukocyte migration  (IDA,IMP)
positive regulation of macrophage chemotaxis  (IDA,IEA,ISO)
positive regulation of monocyte chemotaxis  (IDA,IEA,ISO)
positive regulation of protein targeting to membrane  (IDA)
positive regulation of synaptic transmission  (IDA)
positive regulation of synaptic transmission, glutamatergic  (IEA,ISO,ISS)
positive regulation of T cell activation  (IEA,ISO)
positive regulation of tumor necrosis factor production  (IMP)
positive regulation of wound healing  (IMP)
regulation of cell shape  (ISO)
regulation of vascular endothelial growth factor production  (IEA,ISO)
response to activity  (IEP)
response to amino acid  (IEP)
response to bacterium  (IEA,ISO)
response to cyclosporin A  (IEP)
response to ethanol  (IEP)
response to gamma radiation  (IEP)
response to glucocorticoid  (IEP)
response to hypoxia  (IEP)
response to isolation stress  (IEP)
response to lipopolysaccharide  (IEP)
response to mechanical stimulus  (IEP)
response to progesterone  (IEP)
response to tumor necrosis factor  (IEP)
response to vitamin B3  (IEP)
response to wounding  (IEA,ISO)
response to xenobiotic stimulus  (IEP)
sensory perception of pain  (IEA,ISO,ISS)
transforming growth factor beta receptor signaling pathway  (IMP)
vascular endothelial growth factor receptor signaling pathway  (IMP)

Cellular Component

Molecular Function

References

References - curated
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272. Atorvastatin enhances interleukin-10 levels and improves cardiac function in rats after acute myocardial infarction. Stumpf C, etal., Clin Sci (Lond). 2009 Jan;116(1):45-52.
273. Role of leukotriene B4 receptors in the development of atherosclerosis: potential mechanisms. Subbarao K, etal., Arterioscler Thromb Vasc Biol. 2004 Feb;24(2):369-75. Epub 2003 Dec 1.
274. Chemokine CCL2/MCP-1 negatively regulates metastasis in a highly bone marrow-metastatic mouse breast cancer model. Takahashi M, etal., Clin Exp Metastasis. 2009;26(7):817-28. Epub 2009 Jul 24.
275. Mizoribine Suppresses the Progression of Experimental Peritoneal Fibrosis in a Rat Model. Takahashi S, etal., Nephron Exp Nephrol. 2009 Apr 23;112(2):e59-e69.
276. Urinary monocyte chemoattractant protein-1 (MCP-1) and connective tissue growth factor (CCN2) as prognostic markers for progression of diabetic nephropathy. Tam FW, etal., Cytokine. 2009 Apr 29.
277. Prolonged cold ischemia in rat cardiac allografts promotes ischemia-reperfusion injury and the development of graft coronary artery disease in a linear fashion. Tanaka M, etal., J Heart Lung Transplant. 2005 Nov;24(11):1906-14. Epub 2005 Jul 27.
278. Enhanced production of monocyte chemoattractant protein-1 in the dorsal root ganglia in a rat model of neuropathic pain: possible involvement in the development of neuropathic pain. Tanaka T, etal., Neurosci Res. 2004 Apr;48(4):463-9.
279. Early enhanced expression of interferon-inducible protein-10 (CXCL-10) and other chemokines predicts adverse outcome in severe acute respiratory syndrome. Tang NL, etal., Clin Chem. 2005 Dec;51(12):2333-40. doi: 10.1373/clinchem.2005.054460. Epub 2005 Sep 29.
280. Cytokine profiles of bronchoalveolar lavage fluid in patients with pneumocystis pneumonia. Tasaka S, etal., Microbiol Immunol. 2010 Jul;54(7):425-33.
281. Eotaxin and monocyte chemoattractant protein-1 in chronic eosinophilic pneumonia. Tateno H, etal., Eur Respir J. 2001 May;17(5):962-8.
282. A laboratory model of toxin-induced hemolytic uremic syndrome. Taylor CM, etal., Kidney Int. 1999 Apr;55(4):1367-74.
283. Blocking the CCL2-CCR2 Axis Using CCL2-Neutralizing Antibody Is an Effective Therapy for Hepatocellular Cancer in a Mouse Model. Teng KY, etal., Mol Cancer Ther. 2017 Feb;16(2):312-322. doi: 10.1158/1535-7163.MCT-16-0124. Epub 2016 Dec 15.
284. Tentative Sequence Identification Numbers Tentative Sequence Data IDs. TIGR Gene Index, Rat Data
285. Altered chemokine response in an animal model of multiple organ dysfunction syndrome induced by zymosan. Thomas NJ, etal., J Pediatr Surg. 2005 Mar;40(3):464-9.
286. Reduced plaque formation induced by rosiglitazone in an STZ-diabetes mouse model of atherosclerosis is associated with downregulation of adhesion molecules. Tikellis C, etal., Atherosclerosis. 2008 Jul;199(1):55-64. Epub 2008 Feb 21.
287. HDL-associated lysosphingolipids inhibit NAD(P)H oxidase-dependent monocyte chemoattractant protein-1 production. Tolle M, etal., Arterioscler Thromb Vasc Biol. 2008 Aug;28(8):1542-8. doi: 10.1161/ATVBAHA.107.161042. Epub 2008 May 15.
288. Blocking mast cell-mediated type I hypersensitivity in experimental allergic conjunctivitis by monocyte chemoattractant protein-1/CCR2. Tominaga T, etal., Invest Ophthalmol Vis Sci. 2009 Nov;50(11):5181-8. doi: 10.1167/iovs.09-3637. Epub 2009 Jun 24.
289. Cardiopulmonary alterations in mRNA expression for interleukin-1beta, the interleukin-6 superfamily and CXC-chemokines during development of postischaemic heart failure in the rat. Tonnessen T, etal., Clin Physiol Funct Imaging. 2003 Sep;23(5):263-8.
290. Immune cell recruitment following acoustic trauma. Tornabene SV, etal., Hear Res. 2006 Dec;222(1-2):115-24. Epub 2006 Nov 1.
291. Expression of monocyte chemoattractant protein-1 in the corpus luteum of the rat. Townson DH, etal., Biol Reprod. 1996 Feb;54(2):513-20.
292. CCL2 promotes P2X4 receptor trafficking to the cell surface of microglia. Toyomitsu E, etal., Purinergic Signal. 2012 Jun;8(2):301-10. doi: 10.1007/s11302-011-9288-x. Epub 2012 Jan 6.
293. Enhanced antitumor effects of a bicistronic adenovirus vector expressing both herpes simplex virus thymidine kinase and monocyte chemoattractant protein-1 against hepatocellular carcinoma. Tsuchiyama T, etal., Cancer Gene Ther. 2003 Apr;10(4):260-9. doi: 10.1038/sj.cgt.7700571.
294. Anti-monocyte chemoattractant protein-1 gene therapy prevents dimethylnitrosamine-induced hepatic fibrosis in rats. Tsuruta S, etal., Int J Mol Med. 2004 Nov;14(5):837-42.
295. Strong association of a functional polymorphism in the monocyte chemoattractant protein 1 promoter gene with lupus nephritis. Tucci M, etal., Arthritis Rheum. 2004 Jun;50(6):1842-9.
296. Chemokine synthesis in the HSV-1-infected cornea and its suppression by interleukin-10. Tumpey TM, etal., J Leukoc Biol. 1998 Apr;63(4):486-92.
297. Murine ccl2/cx3cr1 deficiency results in retinal lesions mimicking human age-related macular degeneration. Tuo J, etal., Invest Ophthalmol Vis Sci. 2007 Aug;48(8):3827-36.
298. Anti-monocyte chemoattractant protein-1 gene therapy inhibits restenotic changes (neointimal hyperplasia) after balloon injury in rats and monkeys. Usui M, etal., FASEB J. 2002 Nov;16(13):1838-40. Epub 2002 Sep 5.
299. The chemokine CCL2 modulates Ca2+ dynamics and electrophysiological properties of cultured cerebellar Purkinje neurons. van Gassen KL, etal., Eur J Neurosci. 2005 Jun;21(11):2949-57.
300. Proinflammatory gene expression at chronic periodontitis and peri-implantitis sites in patients with or without type 2 diabetes. Venza I, etal., J Periodontol. 2010 Jan;81(1):99-108. doi: 10.1902/jop.2009.090358.
301. Chemokines in acute anterior uveitis. Verma MJ, etal., Curr Eye Res. 1997 Dec;16(12):1202-8.
302. Social isolation stress facilitates chemically induced oral carcinogenesis. Verza FA, etal., PLoS One. 2021 Jan 7;16(1):e0245190. doi: 10.1371/journal.pone.0245190. eCollection 2021.
303. Increased receptor for advanced glycation end product expression in the human alcoholic prefrontal cortex is linked to adolescent drinking. Vetreno RP, etal., Neurobiol Dis. 2013 Nov;59:52-62. doi: 10.1016/j.nbd.2013.07.002. Epub 2013 Jul 15.
304. Fgr deficiency results in defective eosinophil recruitment to the lung during allergic airway inflammation. Vicentini L, etal., J Immunol. 2002 Jun 15;168(12):6446-54.
305. Distribution in ocular structures and optic pathways of immunocompetent and glial cells in an experimental allergic encephalomyelitis (EAE) relapsing model. Villarroya H, etal., J Neurosci Res. 2001 Mar 15;63(6):525-35.
306. Changes in plasma chemokine C-C motif ligand 2 levels during treatment with eicosapentaenoic acid predict outcome in patients undergoing surgery for colorectal cancer liver metastasis. Volpato M, etal., Oncotarget. 2016 May 10;7(19):28139-50. doi: 10.18632/oncotarget.8579.
307. Intervention of crescentic glomerulonephritis by antibodies to monocyte chemotactic and activating factor (MCAF/MCP-1). Wada T, etal., FASEB J. 1996 Oct;10(12):1418-25.
308. Persistence of lung inflammation and lung cytokines with high-resolution CT abnormalities during recovery from SARS. Wang CH, etal., Respir Res. 2005 May 11;6:42. doi: 10.1186/1465-9921-6-42.
309. Endothelial dysfunction, macrophage infiltration and NADPH oxidase-dependent superoxide production were attenuated by erythropoietin in streptozotocin-induced diabetic rat aorta. Wang J, etal., Pharmacology. 2013;91(1-2):48-58. doi: 10.1159/000343963. Epub 2012 Nov 15.
310. Clinical significance and different levels of urinary monocyte chemoattractant protein-1 in type 2 diabetes mellitus. Wang QY and Chen FQ, Diabetes Res Clin Pract. 2009 Feb;83(2):215-9. Epub 2008 Dec 20.
311. Triptolide inhibits CC chemokines expressed in rat adjuvant-induced arthritis. Wang Y, etal., Int Immunopharmacol. 2006 Dec 5;6(12):1825-32. Epub 2006 Aug 31.
312. Analysis of monocyte chemoattractant protein 1-mediated lung injury using rat lung organ cultures. Warren JS, etal., Am J Pathol. 1993 Sep;143(3):894-906.
313. Cardiac inflammation contributes to right ventricular dysfunction following experimental pulmonary embolism in rats. Watts JA, etal., J Mol Cell Cardiol. 2006 Aug;41(2):296-307. Epub 2006 Jun 30.
314. Role of the CCL2/MCP-1 -2518A>G gene polymorphism in HLA-B27 associated uveitis. Wegscheider BJ, etal., Mol Vis. 2005 Nov 1;11:896-900.
315. Excitatory monocyte chemoattractant protein-1 signaling is up-regulated in sensory neurons after chronic compression of the dorsal root ganglion. White FA, etal., Proc Natl Acad Sci U S A. 2005 Sep 27;102(39):14092-7. Epub 2005 Sep 20.
316. Evidence for less irritation to the peritoneal membrane in rats dialyzed with solutions low in glucose degradation products. Wieczorowska-Tobis K, etal., Perit Dial Int. 2004 Jan-Feb;24(1):48-57.
317. Identification of a retinal aldosterone system and the protective effects of mineralocorticoid receptor antagonism on retinal vascular pathology. Wilkinson-Berka JL, etal., Circ Res. 2009 Jan 2;104(1):124-33. doi: 10.1161/CIRCRESAHA.108.176008. Epub 2008 Nov 26.
318. Influenza A virus infection inhibits the efficient recruitment of Th2 cells into the airways and the development of airway eosinophilia. Wohlleben G, etal., J Immunol. 2003 May 1;170(9):4601-11.
319. Existence of a regulatory loop between MCP-1 and TGF-beta in glomerular immune injury. Wolf G, etal., Am J Physiol Renal Physiol 2002 Nov;283(5):F1075-84.
320. DNA vaccination with naked DNA encoding MCP-1 and RANTES protects against renal injury in adriamycin nephropathy. Wu H, etal., Kidney Int. 2005 Jun;67(6):2178-86.
321. Nifedipine inhibited angiotensin II-induced monocyte chemoattractant protein 1 expression: involvement of inhibitor of nuclear factor kappa B kinase and nuclear factor kappa B-inducing kinase. Wu L, etal., J Hypertens. 2006 Jan;24(1):123-30.
322. Regulation of inhibitory protein-kappaB and monocyte chemoattractant protein-1 by angiotensin II type 2 receptor-activated Src homology protein tyrosine phosphatase-1 in fetal vascular smooth muscle cells. Wu L, etal., Mol Endocrinol. 2004 Mar;18(3):666-78. Epub 2003 Dec 18.
323. Protein kinase C beta inhibitor LY333531 attenuates intercellular adhesion molecule-1 and monocyte chemotactic protein-1 expression in the kidney in diabetic rats. Wu Y, etal., J Pharmacol Sci. 2006 Aug;101(4):335-43. Epub 2006 Aug 5.
324. Estrogen modulates TNF-alpha-induced inflammatory responses in rat aortic smooth muscle cells through estrogen receptor-beta activation. Xing D, etal., Am J Physiol Heart Circ Physiol. 2007 Jun;292(6):H2607-12. Epub 2007 Jan 19.
325. [Effects of N-acetylcysteine on mRNA expression of monocyte chemotactic protein and macrophage inflammatory protein 2 in acute necrotizing pancreatitis: experiment with rats] Xu CF, etal., Zhonghua Yi Xue Za Zhi. 2008 Mar 11;88(10):711-5.
326. Role of KCa3.1 Channels in Macrophage Polarization and Its Relevance in Atherosclerotic Plaque Instability. Xu R, etal., Arterioscler Thromb Vasc Biol. 2017 Feb;37(2):226-236. doi: 10.1161/ATVBAHA.116.308461. Epub 2016 Dec 29.
327. Inhibition of laser-induced choroidal neovascularization by atorvastatin by downregulation of monocyte chemotactic protein-1 synthesis in mice. Yamada K, etal., Invest Ophthalmol Vis Sci. 2007 Apr;48(4):1839-43.
328. A synthetic selective inhibitor of factor Xa, DX-9065a, reduces monocyte chemoattractant protein-1 expression after ischemia-reperfusion injury in rat liver. Yamaguchi Y, etal., Dig Dis Sci. 1999 Dec;44(12):2568-76. doi: 10.1023/a:1026667912632.
329. Monocyte chemoattractant protein-1 enhances expression of intercellular adhesion molecule-1 following ischemia-reperfusion of the liver in rats. Yamaguchi Y, etal., Hepatology. 1998 Mar;27(3):727-34.
330. Role of monocyte chemoattractant protein-1 and its receptor,CCR-2, in the pathogenesis of bleomycin-induced scleroderma. Yamamoto T and Nishioka K, J Invest Dermatol. 2003 Sep;121(3):510-6.
331. Tumor-derived monocyte chemoattractant protein-1 induces intratumoral infiltration of monocyte-derived macrophage subpopulation in transplanted rat tumors. Yamashiro S, etal., Am J Pathol. 1994 Oct;145(4):856-67.
332. Intradermal injection of monocyte chemoattractant protein-1 induces emigration and differentiation of blood monocytes in rat skin. Yamashiro S, etal., Int Arch Allergy Immunol. 1998 Jan;115(1):15-23.
333. Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica Yang H, etal., Zhongguo Zhong Yao Za Zhi. 2008 Dec;33(23):2817-20.
334. Chemokine and chemokine receptor expression during colony stimulating factor-1-induced osteoclast differentiation in the toothless osteopetrotic rat: a key role for CCL9 (MIP-1gamma) in osteoclastogenesis in vivo and in vitro. Yang M, etal., Blood. 2006 Mar 15;107(6):2262-70. doi: 10.1182/blood-2005-08-3365. Epub 2005 Nov 22.
335. Plasma IP-10 and MCP-3 levels are highly associated with disease severity and predict the progression of COVID-19. Yang Y, etal., J Allergy Clin Immunol. 2020 Apr 29. pii: S0091-6749(20)30576-5. doi: 10.1016/j.jaci.2020.04.027.
336. Chemokine gene polymorphisms in idiopathic anterior uveitis. Yeo TK, etal., Cytokine. 2006 Jul;35(1-2):29-35. Epub 2006 Sep 6.
337. Indole-3-propionic acid suppresses indoxyl sulfate-induced expression of fibrotic and inflammatory genes in proximal tubular cells. Yisireyili M, etal., Nagoya J Med Sci. 2017 Nov;79(4):477-486. doi: 10.18999/nagjms.79.4.477.
338. Aqueous humor levels of asymmetric dimethylarginine (ADMA) are positively associated with monocyte chemoattractant protein-1 (MCP-1) in patients with uveitis. Yoshida Y, etal., Br J Ophthalmol. 2008 Jan;92(1):93-4. Epub 2007 Jun 25.
339. Molecular cloning of rat monocyte chemoattractant protein-1 (MCP-1) and its expression in rat spleen cells and tumor cell lines. Yoshimura T, etal., Biochem Biophys Res Commun 1991 Jan 31;174(2):504-9.
340. Chemokine MCP1/CCL2 and RANTES/CCL5 gene polymorphisms influence Henoch-Schonlein purpura susceptibility and severity. Yu HH, etal., J Formos Med Assoc. 2015 Apr;114(4):347-52. doi: 10.1016/j.jfma.2012.12.007. Epub 2013 Feb 1.
341. The role of redox status on chemokine expression in acute pancreatitis. Yubero S, etal., Biochim Biophys Acta. 2009 Feb;1792(2):148-54. Epub 2008 Dec 9.
342. Targeting peripheral immune response reduces the severity of necrotizing acute pancreatitis. Yubero S, etal., Crit Care Med. 2009 Jan;37(1):240-5. doi: 10.1097/CCM.0b013e31819320fc.
343. Sinomenine, an antirheumatic alkaloid, ameliorates clinical signs of disease in the Lewis rat model of acute experimental autoimmune encephalolmyelitis. Zeng Y, etal., Biol Pharm Bull. 2007 Aug;30(8):1438-44.
344. [Effects of astragalus on renal tubulointerestitial lesions and expression of NF-kappaB and MCP-1 in renal tissues in rat experimental IgA nephropathy] Zhang GZ, etal., Zhongguo Dang Dai Er Ke Za Zhi. 2008 Apr;10(2):173-8.
345. Exosome-mediated targeted delivery of miR-210 for angiogenic therapy after cerebral ischemia in mice. Zhang H, etal., J Nanobiotechnology. 2019 Feb 19;17(1):29. doi: 10.1186/s12951-019-0461-7.
346. CCL2-CCR2 signaling promotes hepatic ischemia/reperfusion injury. Zhang J, etal., J Surg Res. 2016 May 15;202(2):352-62. doi: 10.1016/j.jss.2016.02.029. Epub 2016 Mar 3.
347. Lung monocyte chemoattractant protein-1 gene expression in bleomycin-induced pulmonary fibrosis. Zhang K, etal., J Immunol. 1994 Nov 15;153(10):4733-41.
348. Chemokine CCL2 and its receptor CCR2 in the medullary dorsal horn are involved in trigeminal neuropathic pain. Zhang ZJ, etal., J Neuroinflammation. 2012 Jul 9;9:136. doi: 10.1186/1742-2094-9-136.
349. Anti-monocyte chemoattractant protein 1 gene therapy attenuates experimental chronic pancreatitis induced by dibutyltin dichloride in rats. Zhao HF, etal., Gut. 2005 Dec;54(12):1759-67.
350. The role of KCa3.1 channels in cardiac fibrosis induced by pressure overload in rats. Zhao LM, etal., Pflugers Arch. 2015 Nov;467(11):2275-85. doi: 10.1007/s00424-015-1694-4. Epub 2015 Feb 27.
351. Combined association of CCR2-V64I and MCP-1-2518A/G polymorphisms with generalised aggressive periodontitis in Chinese. Zhu XL, etal., Chin J Dent Res. 2010;13(2):109-14.
352. Serum monocyte chemoattractant protein-1 concentrations associate with diabetes status but not arterial stiffness in children with type 1 diabetes. Zineh I, etal., Diabetes Care. 2009 Mar;32(3):465-7. Epub 2008 Dec 17.
353. Therapeutic effects of dichloromethane fraction of Securidaca inappendiculata on adjuvant-induced arthritis in rat. Zuo J, etal., J Ethnopharmacol. 2014 Apr 28;153(2):352-8. doi: 10.1016/j.jep.2014.02.015. Epub 2014 Feb 26.
Additional References at PubMed
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PMID:39136140   PMID:39478585  


Genomics

Comparative Map Data
Ccl2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81067,503,077 - 67,504,875 (+)NCBIGRCr8
mRatBN7.21067,005,424 - 67,007,222 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1067,005,424 - 67,007,226 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1071,626,649 - 71,628,447 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01071,131,996 - 71,133,794 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01066,593,121 - 66,594,919 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01069,412,065 - 69,413,863 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1069,412,017 - 69,413,870 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01069,047,091 - 69,048,889 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41070,256,263 - 70,258,061 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera1065,952,968 - 65,954,766 (+)NCBICelera
Cytogenetic Map10q26NCBI
CCL2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381734,255,285 - 34,257,203 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1734,255,274 - 34,257,208 (+)EnsemblGRCh38hg38GRCh38
GRCh371732,582,304 - 32,584,222 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361729,606,409 - 29,608,335 (+)NCBINCBI36Build 36hg18NCBI36
Build 341729,606,408 - 29,608,331NCBI
Celera1729,492,130 - 29,494,042 (+)NCBICelera
Cytogenetic Map17q12NCBI
HuRef1728,767,599 - 28,769,525 (+)NCBIHuRef
CHM1_11732,646,183 - 32,648,095 (+)NCBICHM1_1
T2T-CHM13v2.01735,201,562 - 35,203,480 (+)NCBIT2T-CHM13v2.0
Ccl2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391181,926,403 - 81,928,278 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1181,926,397 - 81,928,279 (+)EnsemblGRCm39 Ensembl
GRCm381182,035,577 - 82,037,452 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1182,035,571 - 82,037,453 (+)EnsemblGRCm38mm10GRCm38
MGSCv371181,849,079 - 81,850,954 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361181,851,769 - 81,853,422 (+)NCBIMGSCv36mm8
Celera1191,649,026 - 91,650,901 (+)NCBICelera
Cytogenetic Map11B5NCBI
cM Map1149.82NCBI
CCL2
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21930,208,206 - 30,210,212 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11732,089,476 - 32,091,422 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01722,528,154 - 22,530,091 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11722,821,336 - 22,823,271 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1722,820,890 - 22,823,384 (-)Ensemblpanpan1.1panPan2
CCL2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1939,008,187 - 39,009,932 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha938,231,467 - 38,233,216 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0939,822,383 - 39,824,132 (-)NCBIROS_Cfam_1.0
UMICH_Zoey_3.1938,608,720 - 38,610,469 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0938,897,447 - 38,899,196 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0938,976,777 - 38,978,526 (-)NCBIUU_Cfam_GSD_1.0
CCL2
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1240,798,109 - 40,800,026 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11240,798,109 - 40,800,013 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21242,514,202 - 42,516,108 (+)NCBISscrofa10.2Sscrofa10.2susScr3
CCL2
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11627,763,354 - 27,765,437 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1627,763,555 - 27,765,416 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_0236660752,254,637 - 2,256,540 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0

Variants

.
Variants in Ccl2
16 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:28
Count of miRNA genes:21
Interacting mature miRNAs:28
Transcripts:ENSRNOT00000009448
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1549846Scl47Serum cholesterol level QTL 473.6blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)105057470795574707Rat
152025229Scl83Serum cholesterol level QTL 834.33blood cholesterol amount (VT:0000180)103571058068663659Rat
1578779Tcas10Tongue tumor susceptibility QTL 103.12tongue integrity trait (VT:0010553)number of squamous cell tumors of the tongue with diameter greater than 3 mm (CMO:0001950)103129743976297439Rat
152025227Bw195Body weight QTL 1955.73body mass (VT:0001259)104698969968663659Rat
631565Hcuc4Hepatic copper content QTL 44.15liver copper amount (VT:0003065)liver copper weight to liver dry weight ratio (CMO:0001512)106694181373452992Rat
1298069Bp168Blood pressure QTL 1685.5blood pressure trait (VT:0000183)systolic blood pressure (CMO:0000004)102652195798003205Rat
8657410Bp374Blood pressure QTL 374heart left ventricle size trait (VT:0002753)heart left ventricle end-diastolic diameter (CMO:0000982)106697895567750281Rat
2293669Bmd33Bone mineral density QTL 334.50.0001femur strength trait (VT:0010010)femoral neck polar moment of inertia (CMO:0001670)104944455181709989Rat
152025224Bw193Body weight QTL 1936.47body mass (VT:0001259)105166340575085664Rat
631552Vetf2Vascular elastic tissue fragility QTL 24.50.0002aorta elastic tissue integrity trait (VT:0010556)artery internal elastic lamina non-tumorous lesion count (CMO:0001913)104114263386142633Rat
61449Ciaa2CIA Autoantibody QTL 27.1blood autoantibody amount (VT:0003725)calculated serum anti-type 2 collagen antibody titer (CMO:0001279)1063221094107211142Rat
631557Bp136Blood pressure QTL 1360.003arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)103063205375632053Rat
61325Aia5Adjuvant induced arthritis QTL 50.01joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1023444813104060283Rat
1298078Stresp5Stress response QTL 52.990.00025blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)1042045676104670812Rat
2293679Bmd30Bone mineral density QTL 303.50.0001femur mineral mass (VT:0010011)total volumetric bone mineral density (CMO:0001728)104944455181709989Rat
1549831Bss6Bone structure and strength QTL 64lumbar vertebra strength trait (VT:0010574)vertebra ultimate force (CMO:0001678)1057576521102576521Rat
12903252Cm113Cardiac mass QTL 1130.047heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)106631944767750281Rat
70164Bw21Body weight QTL 214.360.00005body mass (VT:0001259)body weight (CMO:0000012)105379749498952626Rat
61463Bp12Blood pressure QTL 126.30.0001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)104133325886333258Rat
8694173Bw149Body weight QTL 1494.380.001body mass (VT:0001259)body weight gain (CMO:0000420)104444169989441699Rat
2300218Hpcl2Hepatic cholesterol level QTL 2liver cholesterol amount (VT:0010498)liver cholesterol level (CMO:0001597)104502965095600334Rat
1554317Bmd4Bone mineral density QTL 49.40.0001lumbar vertebra mineral mass (VT:0010511)volumetric bone mineral density (CMO:0001553)101981604299406971Rat
70171Cari1Carrageenan-induced inflammation QTL 14.90.0005hypodermis integrity trait (VT:0010550)inflammatory exudate volume (CMO:0001429)1053797385107211142Rat
12903269Am15Aortic mass QTL 150.042aorta mass (VT:0002845)aorta weight to aorta length to body weight ratio (CMO:0002722)106631944767750281Rat
724527Bp148Blood pressure QTL 1480.0001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)102845313673453136Rat
12903266Cm114Cardiac mass QTL 1140.02heart right ventricle mass (VT:0007033)heart right ventricle weight to body weight ratio (CMO:0000914)106631944767750281Rat
2300171Bmd58Bone mineral density QTL 584.90.0001lumbar vertebra mineral mass (VT:0010511)volumetric bone mineral density (CMO:0001553)102694462871944628Rat
61354Pia10Pristane induced arthritis QTL 100.01joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1023444813104060283Rat
2301967Cm73Cardiac mass QTL 734.55heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)101448701189062041Rat
2313103Bss80Bone structure and strength QTL 8020.0001tibia strength trait (VT:1000284)tibia midshaft endosteal cross-sectional area (CMO:0001716)1062057807107057807Rat
2303118Mamtr7Mammary tumor resistance QTL 70.003mammary gland integrity trait (VT:0010552)mammary tumor growth rate (CMO:0000344)109658275104670812Rat
70188BpQTLcluster1Blood pressure QTL cluster 14.864arterial blood pressure trait (VT:2000000)pulse pressure (CMO:0000292)14232313287323132Rat
12880372Am12Aortic mass QTL 120.003aorta mass (VT:0002845)aorta weight to aorta length to body weight ratio (CMO:0002722)106631944768164786Rat
2313105Bss79Bone structure and strength QTL 791.80.0001tibia size trait (VT:0100001)tibia midshaft cross-sectional area (CMO:0001717)1062057807107057807Rat
12880375Kidm66Kidney mass QTL 660.009kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)106631944768164786Rat
9589030Epfw9Epididymal fat weight QTL 919.240.001epididymal fat pad mass (VT:0010421)epididymal fat pad weight to body weight ratio (CMO:0000658)104444169989441699Rat
1357344Bp249Blood pressure QTL 2490.0001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)106674365598003205Rat
10402859Bp381Blood pressure QTL 3810.002arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)102760646872606468Rat
2316949Gluco60Glucose level QTL 603.7blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)1014487011107057807Rat
2293652Bmd22Bone mineral density QTL 224.90.0001femur mineral mass (VT:0010011)total volumetric bone mineral density (CMO:0001728)104944455181709989Rat
12880370Cm105Cardiac mass QTL 1050.008heart mass (VT:0007028)heart wet weight to body weight ratio (CMO:0002408)106631944768164786Rat
70198BpQTLcluster9Blood pressure QTL cluster 92.94arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)104232313287323132Rat
12880371Cm106Cardiac mass QTL 1060.007heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)106631944768164786Rat
2306970Anxrr22Anxiety related response QTL 225.95fear/anxiety-related behavior trait (VT:1000241)number of periods of voluntary immobility (CMO:0001045)106134527698211570Rat
1359017Hrtrt21Heart rate QTL 212.4heart pumping trait (VT:2000009)heart rate (CMO:0000002)105177294096772940Rat
11565453Kidm58Kidney mass QTL 580.002kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)106631944767750281Rat
7387312Bw125Body weight QTL 12530.0047retroperitoneal fat pad mass (VT:0010430)retroperitoneal fat pad weight (CMO:0000356)1064890616107211142Rat
2312672Insul15Insulin level QTL 150.01blood insulin amount (VT:0001560)serum insulin level (CMO:0000358)1057134272102134272Rat
2317029Aia19Adjuvant induced arthritis QTL 192.98joint integrity trait (VT:0010548)left rear ankle joint diameter (CMO:0002149)1066978955107211142Rat
724556Pur2Proteinuria QTL 25.5urine protein amount (VT:0005160)urine protein level (CMO:0000591)102242750090627625Rat
8662860Vetf10Vascular elastic tissue fragility QTL 10artery integrity trait (VT:0010639)number of ruptures of the internal elastic lamina of the abdominal aorta and iliac arteries (CMO:0002562)10615418273453136Rat
61387Bp1Blood pressure QTL 15.1arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)1051770177107211142Rat
2317039Aia6Adjuvant induced arthritis QTL 64.31joint integrity trait (VT:0010548)right rear ankle joint diameter (CMO:0002150)1066978955107211142Rat
70223Bp57Blood pressure QTL 575arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)10180676123Rat
2317043Aia7Adjuvant induced arthritis QTL 73.82joint integrity trait (VT:0010548)left rear ankle joint diameter (CMO:0002149)103756507982565079Rat
2317042Aia20Adjuvant induced arthritis QTL 203.38joint integrity trait (VT:0010548)right rear ankle joint diameter (CMO:0002150)103756507982565079Rat
2298481Eau9Experimental allergic uveoretinitis QTL 90.0169uvea integrity trait (VT:0010551)experimental autoimmune uveitis score (CMO:0001504)106592723382565079Rat
70363Bp71Blood pressure QTL 710.04arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)106134527681714865Rat
61402Niddm3Non-insulin dependent diabetes mellitus QTL 34.58blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)106134541382564856Rat
1331791Cm31Cardiac mass QTL 313.84606heart mass (VT:0007028)heart wet weight (CMO:0000069)1029299504107211142Rat
70364Bp72Blood pressure QTL 72arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)105112110096121100Rat
2293698Bss43Bone structure and strength QTL 435.330.0001lumbar vertebra size trait (VT:0010518)lumbar vertebra cross-sectional area (CMO:0001689)1059209888104209888Rat
631530Tls3T-lymphoma susceptibility QTL 300.0001thymus integrity trait (VT:0010555)percentage of study population developing T-cell lymphomas during a period of time (CMO:0001911)105177461295600334Rat
1354608Cm33Cardiac mass QTL 332.8heart left ventricle mass (VT:0007031)heart left ventricle wet weight (CMO:0000071)105480929299809292Rat
1558643Cm44Cardiac mass QTL 444.80.0000368heart mass (VT:0007028)heart wet weight (CMO:0000069)106134527699703528Rat
631535Cm51Cardiac mass QTL 513heart mass (VT:0007028)calculated heart weight (CMO:0000073)105178628291669536Rat
1576319Cia29Collagen induced arthritis QTL 29joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)103397392178973921Rat
8552805Bw145Body weight QTL 1452.2body mass (VT:0001259)change in body weight to body weight ratio (CMO:0002216)104194452678307017Rat
631267Cia20Collagen induced arthritis QTL 203.2joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1023444813104060283Rat
2293705Bmd25Bone mineral density QTL 257.10.0001femur mineral mass (VT:0010011)compact volumetric bone mineral density (CMO:0001730)104944455181709989Rat
1331839Eae18bExperimental allergic encephalomyelitis QTL 18b5.80.03nervous system integrity trait (VT:0010566)experimental autoimmune encephalomyelitis severity score (CMO:0001419)106124830367785171Rat
1576308Schws1Schwannoma susceptibility QTL 10.0041nervous system integrity trait (VT:0010566)percentage of study population developing trigeminal nerve neurilemmomas during a period of time (CMO:0002017)1040035094102359817Rat
631269Cia22Collagen induced arthritis QTL 228.9joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1040035094104060283Rat
631268Cia21Collagen induced arthritis QTL 213.1joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1014487011104060283Rat
7207811Bmd90Bone mineral density QTL 905.2femur size trait (VT:1000369)femoral neck cross-sectional area (CMO:0001697)104944455181709989Rat
1576311Pia26Pristane induced arthritis QTL 26joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)103122402675632053Rat
631270Cia23Collagen induced arthritis QTL 233.9joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1040035094104060283Rat
7411614Foco18Food consumption QTL 180.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)104444169989441699Rat
6893336Cm75Cardiac mass QTL 750.10.87heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)106134527699703528Rat
631547Bp87Blood pressure QTL 874.5arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)104736947092369470Rat
61427Cia16Collagen induced arthritis QTL 163.2joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)10635789696121100Rat
2312662Slep8Serum leptin concentration QTL 80.05blood leptin amount (VT:0005667)serum leptin level (CMO:0000780)1057134272102134272Rat
6893342Cm78Cardiac mass QTL 780.10.88heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)104287676679813922Rat
2292441Bp308Blood pressure QTL 308arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)102760646872606468Rat
2301405Cm69Cardiac mass QTL 690.031heart mass (VT:0007028)heart wet weight to body weight ratio (CMO:0002408)106631944767750281Rat
631542Bp82Blood pressure QTL 826.8arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)102652195798952741Rat
2312668Scl65Serum cholesterol level QTL 650.001blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)1057134272102134272Rat

Markers in Region
D10Kyo2   No map positions available.
PMC145384P1  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21067,006,270 - 67,006,928 (+)MAPPERmRatBN7.2
Rnor_6.01069,412,912 - 69,413,569NCBIRnor6.0
Rnor_5.01069,047,938 - 69,048,595UniSTSRnor5.0
RGSC_v3.41070,257,110 - 70,257,767UniSTSRGSC3.4
Celera1065,953,815 - 65,954,472UniSTS
Cytogenetic Map10q26UniSTS
Scya2  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21067,005,939 - 67,006,013 (+)MAPPERmRatBN7.2
Rnor_6.01069,412,581 - 69,412,654NCBIRnor6.0
Rnor_5.01069,047,607 - 69,047,680UniSTSRnor5.0
RGSC_v3.41070,256,779 - 70,256,852UniSTSRGSC3.4
Celera1065,953,484 - 65,953,557UniSTS
Cytogenetic Map10q26UniSTS
RH134870  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21067,006,913 - 67,007,108 (+)MAPPERmRatBN7.2
Rnor_6.01069,413,555 - 69,413,749NCBIRnor6.0
Rnor_5.01069,048,581 - 69,048,775UniSTSRnor5.0
RGSC_v3.41070,257,753 - 70,257,947UniSTSRGSC3.4
Celera1065,954,458 - 65,954,652UniSTS
Cytogenetic Map10q26UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
nervous system
renal system
reproductive system
respiratory system
9 11 47 108 91 90 59 25 59 6 216 95 88 45 58 31

Sequence


Ensembl Acc Id: ENSRNOT00000009448   ⟹   ENSRNOP00000009448
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1067,005,424 - 67,007,226 (+)Ensembl
Rnor_6.0 Ensembl1069,412,017 - 69,413,870 (+)Ensembl
RefSeq Acc Id: NM_031530   ⟹   NP_113718
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81067,503,077 - 67,504,875 (+)NCBI
mRatBN7.21067,005,424 - 67,007,222 (+)NCBI
Rnor_6.01069,412,065 - 69,413,863 (+)NCBI
Rnor_5.01069,047,091 - 69,048,889 (+)NCBI
RGSC_v3.41070,256,263 - 70,258,061 (+)RGD
Celera1065,952,968 - 65,954,766 (+)RGD
Sequence:
Protein Sequences
Protein RefSeqs NP_113718 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAA63496 (Get FASTA)   NCBI Sequence Viewer  
  AAC15187 (Get FASTA)   NCBI Sequence Viewer  
  CAA34901 (Get FASTA)   NCBI Sequence Viewer  
  EDM05437 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000009448
  ENSRNOP00000009448.1
GenBank Protein P14844 (Get FASTA)   NCBI Sequence Viewer  
RefSeq Acc Id: NP_113718   ⟸   NM_031530
- Peptide Label: precursor
- UniProtKB: Q549R5 (UniProtKB/Swiss-Prot),   P14844 (UniProtKB/Swiss-Prot),   A6HHD2 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000009448   ⟸   ENSRNOT00000009448
Protein Domains
Chemokine interleukin-8-like

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P14844-F1-model_v2 AlphaFold P14844 1-148 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13697507
Promoter ID:EPDNEW_R8032
Type:multiple initiation site
Name:Ccl2_1
Description:C-C motif chemokine ligand 2
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.01069,412,065 - 69,412,125EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:3645 AgrOrtholog
BioCyc Gene G2FUF-23937 BioCyc
Ensembl Genes ENSRNOG00000007159 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000009448 ENTREZGENE
  ENSRNOT00000009448.4 UniProtKB/Swiss-Prot
Gene3D-CATH 2.40.50.40 UniProtKB/Swiss-Prot
InterPro Chemokine_b/g/d UniProtKB/Swiss-Prot
  Chemokine_CC_CS UniProtKB/Swiss-Prot
  Chemokine_IL8-like_dom UniProtKB/Swiss-Prot
  Interleukin_8-like_sf UniProtKB/Swiss-Prot
KEGG Report rno:24770 UniProtKB/Swiss-Prot
NCBI Gene 24770 ENTREZGENE
PANTHER C-C MOTIF CHEMOKINE 2 UniProtKB/Swiss-Prot
  PTHR12015 UniProtKB/Swiss-Prot
Pfam IL8 UniProtKB/Swiss-Prot
PhenoGen Ccl2 PhenoGen
PROSITE SMALL_CYTOKINES_CC UniProtKB/Swiss-Prot
RatGTEx ENSRNOG00000007159 RatGTEx
SMART SCY UniProtKB/Swiss-Prot
Superfamily-SCOP SSF54117 UniProtKB/Swiss-Prot
TIGR TC205265
UniProt A6HHD2 ENTREZGENE, UniProtKB/TrEMBL
  CCL2_RAT UniProtKB/Swiss-Prot, ENTREZGENE
  Q549R5 ENTREZGENE
UniProt Secondary Q549R5 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2016-03-08 Ccl2  C-C motif chemokine ligand 2  Ccl2  chemokine (C-C motif) ligand 2  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2004-02-26 Ccl2  chemokine (C-C motif) ligand 2  Scya2  small inducible cytokine A2  Symbol and Name updated 625702 APPROVED
2002-06-10 Scya2  small inducible cytokine A2      Name updated 70585 PROVISIONAL

RGD Curation Notes
Note Type Note Reference
gene_expression increases slightly during renal allografts and isografts 61510
gene_expression mRNA is isolated from the glomeruli of perfused kidneys 625742
gene_physical_interaction may bind with Tgf beta during glomerular immune injury 625742
gene_process induces Tgf-beta expression 625742
gene_regulation expression is upregulated by NF-kappaB in an IL-1beta-induced manner 634051
gene_regulation expression is upregulated by Con A 634050
gene_regulation protein synthesis is increased by cerulein hyperstimulation in rat pancreatic acini through a calcium-dependent mechanism involving NF-kB activation 625742
gene_regulation antibody against acetylcholine receptor increases protein production both in cultured LE1 myocytes and in skeletal muscle in Lewis rats 625742