S100b (S100 calcium binding protein B) - Rat Genome Database

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Gene: S100b (S100 calcium binding protein B) Rattus norvegicus
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Symbol: S100b
Name: S100 calcium binding protein B
RGD ID: 3615
Description: Enables RAGE receptor binding activity; identical protein binding activity; and metal ion binding activity. Involved in several processes, including long-term synaptic potentiation; positive regulation of myelination; and response to anesthetic. Located in extracellular space. Used to study demyelinating disease. Biomarker of several diseases, including bipolar disorder; borna disease; brain edema; cerebrovascular disease (multiple); and depressive disorder. Human ortholog(s) of this gene implicated in Alzheimer's disease; aspergillosis; and schizophrenia. Orthologous to human S100B (S100 calcium binding protein B); PARTICIPATES IN calcium/calcium-mediated signaling pathway; INTERACTS WITH (+)-pilocarpine; (R)-lipoic acid; 1,2-dimethylhydrazine.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: MGC93559; protein S100-B; S-100 protein beta chain; S-100 protein subunit beta; S100 calcium-binding protein B; S100 calcium-binding protein beta (neural); S100 calcium-binding protein, beta (neural); S100 protein, beta polypeptide; S100 protein, beta polypeptide, neural; S100P
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr82012,372,345 - 12,381,159 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl2012,372,348 - 12,381,081 (-)EnsemblGRCr8
mRatBN7.22012,372,866 - 12,381,619 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl2012,372,881 - 12,394,743 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx2013,071,830 - 13,080,530 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.02012,432,755 - 12,441,455 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.02012,904,538 - 12,913,238 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.02013,130,633 - 13,142,856 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl2013,130,636 - 13,142,856 (-)Ensemblrn6Rnor6.0
Rnor_5.02015,287,745 - 15,296,485 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.42012,791,440 - 12,824,508 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera2013,867,276 - 13,875,895 (-)NCBICelera
RGSC_v3.12012,791,666 - 12,824,735 (-)NCBI
Cytogenetic Map20p12NCBI
JBrowse:




Disease Annotations     Click to see Annotation Detail View
Acute Coronary Syndrome  (ISO)
Alzheimer's disease  (IEP,ISO)
Animal Disease Models  (ISO)
aspergillosis  (ISO)
asphyxia neonatorum  (ISO)
Attention Deficit and Disruptive Behavior Disorders  (ISO)
autistic disorder  (ISO)
Axenfeld-Rieger syndrome type 3  (ISO)
bacterial meningitis  (ISO)
Binge Drinking  (IEP)
bipolar disorder  (IEP,ISO)
borna disease  (IEP)
brain disease  (ISO)
brain edema  (IEP,ISO)
Brain Hypoxia-Ischemia  (ISO)
Brain Injuries  (ISO)
brain ischemia  (IEP)
Brain Neoplasms  (ISO)
Cerebral Hemorrhage  (ISO)
Creutzfeldt-Jakob disease  (ISO)
demyelinating disease  (IDA)
Dental Pulp Exposure  (IEP)
depressive disorder  (IEP)
Diffuse Brain Injuries  (ISO)
dilated cardiomyopathy  (ISO)
Down syndrome  (ISO)
Experimental Diabetes Mellitus  (IEP)
Experimental Seizures  (IEP)
Femoral Fractures  (IEP)
Hematoma  (IEP,ISO)
hepatic encephalopathy  (ISO)
hypertension  (ISO)
Hypotension  (IEP)
Inflammation  (ISO)
intracranial vasospasm  (ISO)
intrahepatic cholangiocarcinoma  (ISO)
invasive aspergillosis  (ISO)
Machado-Joseph disease  (ISO)
malignant mesothelioma  (ISO)
Mercury Poisoning, Nervous System  (ISO)
middle cerebral artery infarction  (IEP)
migraine without aura  (ISO)
myocardial infarction  (IEP,ISO)
Myocardial Reperfusion Injury  (IEP)
nephrotoxicity  (IEP)
neuromyelitis optica  (ISO)
Parkinson's disease  (ISO)
relapsing-remitting multiple sclerosis  (ISO)
Reperfusion Injury  (IEP)
schizophrenia  (ISO)
Sepsis  (ISO)
sleep apnea  (IEP)
Spinal Fractures  (ISO)
Sporadic Creutzfeldt-Jakob Disease  (ISO)
Stroke  (IEP,ISO)
urinary bladder cancer  (IEP)
West Nile fever  (ISO)

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-catechin  (ISO)
(+)-pilocarpine  (EXP)
(R)-lipoic acid  (EXP)
(R)-noradrenaline  (ISO)
(S)-nicotine  (ISO)
1,2-dimethylhydrazine  (EXP,ISO)
1-chloro-2,4-dinitrobenzene  (ISO)
17beta-estradiol  (ISO)
2,2,2-tetramine  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,3,7,8-Tetrachlorodibenzofuran  (EXP)
2-palmitoylglycerol  (ISO)
3',5'-cyclic AMP  (ISO)
3,3',5,5'-tetrabromobisphenol A  (ISO)
3,4-dihydroxybenzaldehyde  (ISO)
3,7-dihydropurine-6-thione  (EXP)
3-[3-(tert-butylsulfanyl)-1-(4-chlorobenzyl)-5-(propan-2-yl)-1H-indol-2-yl]-2,2-dimethylpropanoic acid  (EXP)
3-isobutyl-1-methyl-7H-xanthine  (ISO)
4-(ethoxymethylene)-2-phenyloxazol-5-one  (ISO)
6-propyl-2-thiouracil  (EXP)
9-cis-retinoic acid  (ISO)
aconitine  (ISO)
aldehydo-D-glucose  (ISO)
all-trans-retinoic acid  (ISO)
alpha-Zearalanol  (EXP)
aluminium atom  (EXP)
aluminium(0)  (EXP)
aminoguanidine  (EXP)
ammonia  (EXP)
ammonium chloride  (EXP)
Anatoxin a  (ISO)
aripiprazole  (ISO)
arsenous acid  (ISO)
astemizole  (EXP)
azithromycin  (ISO)
benzo[a]pyrene  (ISO)
bexarotene  (EXP)
bisphenol A  (EXP,ISO)
bisphenol F  (ISO)
buspirone  (ISO)
C60 fullerene  (EXP)
cadmium dichloride  (EXP,ISO)
calcitriol  (ISO)
capsaicin  (EXP)
carbofuran  (EXP)
carbon nanotube  (ISO)
CGP 52608  (ISO)
chitosan  (EXP)
choline  (ISO)
chrysin  (ISO)
cobalt atom  (ISO)
cocaine  (EXP)
corticosterone  (EXP)
Cuprizon  (ISO)
cycloheximide  (EXP)
cyclophosphamide  (ISO)
D-glucose  (ISO)
dexamethasone  (ISO)
diarsenic trioxide  (ISO)
diazinon  (EXP)
dibenziodolium  (ISO)
dibutyl phthalate  (EXP)
diethylstilbestrol  (EXP)
dimethoate  (EXP)
disodium cromoglycate  (EXP)
diuron  (EXP)
dorsomorphin  (ISO)
endosulfan  (EXP)
entinostat  (ISO)
ethanol  (EXP,ISO)
fluoxetine  (EXP,ISO)
folic acid  (ISO)
fructose  (ISO)
furosemide  (EXP)
glucose  (ISO)
glyphosate  (EXP,ISO)
GSK-J4  (ISO)
heparin  (EXP)
hydrogen peroxide  (EXP)
hydroquinone  (ISO)
indometacin  (ISO)
ketamine  (EXP)
L-ascorbic acid  (EXP,ISO)
L-methionine  (ISO)
lead diacetate  (EXP)
lipoic acid  (EXP)
manganese(II) chloride  (ISO)
mercaptopurine  (EXP)
mercury atom  (ISO)
mercury(0)  (ISO)
Mesaconitine  (ISO)
methylmercury chloride  (EXP)
microcystin-LR  (ISO)
monascin  (ISO)
mono(2-ethylhexyl) phthalate  (ISO)
monobenzyl phthalate  (ISO)
Monobutylphthalate  (ISO)
monoethyl phthalate  (ISO)
morphine  (ISO)
N-[2-(4-bromocinnamylamino)ethyl]isoquinoline-5-sulfonamide  (EXP)
nickel sulfate  (ISO)
nicotine  (ISO)
nitric oxide  (EXP,ISO)
nitroprusside  (EXP)
ouabain  (EXP)
oxidopamine  (ISO)
panobinostat  (ISO)
paracetamol  (ISO)
paraquat  (EXP,ISO)
PCB138  (EXP)
perfluorooctane-1-sulfonic acid  (EXP)
perfluorooctanoic acid  (EXP,ISO)
phenethyl caffeate  (EXP)
phenylephrine  (EXP)
phorbol 13-acetate 12-myristate  (ISO)
pirinixic acid  (EXP)
purine-6-thiol  (EXP)
quercetin  (ISO)
reactive oxygen species  (EXP,ISO)
resveratrol  (EXP)
risperidone  (EXP)
sarin  (EXP)
SB 203580  (ISO)
SB 431542  (ISO)
sodium arsenite  (ISO)
sodium dodecyl sulfate  (ISO)
Soman  (EXP)
streptozocin  (EXP)
thioacetamide  (EXP)
titanium dioxide  (ISO)
trichostatin A  (ISO)
triphenyl phosphate  (EXP)
triptonide  (ISO)
Tungsten carbide  (ISO)
valproic acid  (ISO)
veliparib  (ISO)
vinclozolin  (EXP)
vitamin E  (EXP)
vorinostat  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component
ciliary basal body  (IEA,ISO)
cilium  (IEA,ISO)
cytoplasm  (IBA,IEA,ISO,ISS)
cytosol  (IEA,ISO)
extracellular region  (IEA,ISO)
extracellular space  (IBA,IDA)
microtubule cytoskeleton  (IEA,ISO)
neuronal cell body  (IEA,ISO)
nucleoplasm  (IEA,ISO)
nucleus  (IBA,IEA,ISO)
perinuclear region of cytoplasm  (IEA,ISO)
ruffle  (IEA,ISO)

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. S100B expression in and effects on microglia. Adami C, etal., Glia. 2001 Feb;33(2):131-42.
2. Effect of endurance exercise training on the expression of GFAP, S100B, and NSE in the striatum of chronic/progressive mouse model of Parkinson's disease. Al-Jarrah MD and Jamous M, NeuroRehabilitation. 2011;28(4):359-63.
3. Intermittent hypoxia during sleep induces reactive gliosis and limited neuronal death in rats: implications for sleep apnea. Aviles-Reyes RX, etal., J Neurochem. 2010 Feb;112(4):854-69. Epub 2009 Dec 10.
4. Melatonin reduces glial reactivity in the hippocampus, cortex, and cerebellum of streptozotocin-induced diabetic rats. Baydas G, etal., Free Radic Biol Med. 2003 Oct 1;35(7):797-804.
5. Systemic markers of inflammation are independently associated with S100B concentration: results of an observational study in subjects with acute ischaemic stroke. Beer C, etal., J Neuroinflammation. 2010 Oct 29;7:71.
6. Trajectory analysis of serum biomarker concentrations facilitates outcome prediction after pediatric traumatic and hypoxemic brain injury. Berger RP, etal., Dev Neurosci. 2010;32(5-6):396-405. Epub 2010 Sep 18.
7. Neurobiochemical markers of brain damage in cerebrospinal fluid of acute ischemic stroke patients. Brouns R, etal., Clin Chem. 2010 Mar;56(3):451-8. Epub 2009 Dec 3.
8. S100B Protein Regulates Astrocyte Shape and Migration via Interaction with Src Kinase: IMPLICATIONS FOR ASTROCYTE DEVELOPMENT, ACTIVATION, AND TUMOR GROWTH. Brozzi F, etal., J Biol Chem. 2009 Mar 27;284(13):8797-811. Epub 2009 Jan 15.
9. A single course of antenatal betamethasone reduces neurotrophic factor S100B concentration in the hippocampus and serum in the neonatal rat. Bruschettini M, etal., Brain Res Dev Brain Res. 2005 Oct 6;159(2):113-8.
10. Association of increased S100B, S100A6 and S100P in serum levels with acute coronary syndrome and also with the severity of myocardial infarction in cardiac tissue of rat models with ischemia-reperfusion injury. Cai XY, etal., Atherosclerosis. 2011 Aug;217(2):536-42. Epub 2011 May 27.
11. Pulpar tooth injury induces plastic changes in S100B positive astroglial cells in the trigeminal subnucleus caudalis. Canzobre MC and Rios H, Neurosci Lett. 2010 Feb 5;470(1):71-5. Epub 2009 Dec 30.
12. Peripheral administration of human adrenomedullin and its binding protein attenuates stroke-induced apoptosis and brain injury in rats. Chaung WW, etal., Mol Med. 2011;17(9-10):1075-83. doi: 10.2119/molmed.2010.00104. Epub 2011 Jun 17.
13. Serum levels of S100B and NSE proteins in Alzheimer's disease patients. Chaves ML, etal., J Neuroinflammation. 2010 Jan 27;7:6.
14. The role of cerebrospinal fluid 14-3-3 and other proteins in the diagnosis of sporadic Creutzfeldt-Jakob disease in the UK: a 10-year review. Chohan G, etal., J Neurol Neurosurg Psychiatry. 2010 Nov;81(11):1243-8. Epub 2010 Sep 20.
15. Insulin reduces cerebral ischemia/reperfusion injury in the hippocampus of diabetic rats: a role for glycogen synthase kinase-3beta. Collino M, etal., Diabetes. 2009 Jan;58(1):235-42. Epub 2008 Oct 7.
16. Genetically-determined hyperfunction of the S100B/RAGE axis is a risk factor for aspergillosis in stem cell transplant recipients. Cunha C, etal., PLoS One. 2011;6(11):e27962. doi: 10.1371/journal.pone.0027962. Epub 2011 Nov 17.
17. Methylmercury increases S100B content in rat cerebrospinal fluid. Farina M, etal., Environ Toxicol Pharmacol. 2005 Feb;19(2):249-53.
18. Usefulness of serum S100B as a marker for the acute phase of aquaporin-4 autoimmune syndrome. Fujii C, etal., Neurosci Lett. 2011 Apr 20;494(1):86-8. Epub 2011 Mar 1.
19. SOX10 transactivates S100B to suppress Schwann cell proliferation and to promote myelination. Fujiwara S, etal., PLoS One. 2014 Dec 23;9(12):e115400. doi: 10.1371/journal.pone.0115400. eCollection 2014.
20. Astrocytes are an early target in osmotic demyelination syndrome. Gankam Kengne F, etal., J Am Soc Nephrol. 2011 Oct;22(10):1834-45. Epub 2011 Sep 1.
21. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
22. Increased S100B in cerebrospinal fluid of infants with bacterial meningitis: relationship to brain damage and routine cerebrospinal fluid findings. Gazzolo D, etal., Clin Chem. 2004 May;50(5):941-4.
23. Urinary S100B protein measurements: A tool for the early identification of hypoxic-ischemic encephalopathy in asphyxiated full-term infants. Gazzolo D, etal., Crit Care Med. 2004 Jan;32(1):131-6.
24. Brain damage following severe acute normovolemic hemodilution in combination with controlled hypotension in rats. Ge YL, etal., Acta Anaesthesiol Scand. 2007 Nov;51(10):1331-7.
25. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
26. High glutamate decreases S100B secretion stimulated by serum deprivation in astrocytes. Goncalves D, etal., Neuroreport 2002 Aug 27;13(12):1533-5.
27. Increased serum S-100B and neuron specific enolase - Potential markers of early nervous system involvement in essential hypertension. Gonzalez-Quevedo A, etal., Clin Biochem. 2011 Feb;44(2-3):154-9. Epub 2010 Dec 1.
28. Septic encephalopathy: relationship to serum and cerebrospinal fluid levels of adhesion molecules, lipid peroxides and S-100B protein. Hamed SA, etal., Neuropediatrics. 2009 Apr;40(2):66-72. Epub 2009 Oct 6.
29. Cannabinoid CB1 receptor stimulation affords neuroprotection in MPTP-induced neurotoxicity by attenuating S100B up-regulation in vitro. Iuvone T, etal., J Mol Med (Berl). 2007 Dec;85(12):1379-92. Epub 2007 Jul 17.
30. S100B and brain natriuretic peptide predict functional neurological outcome after intracerebral haemorrhage. James ML, etal., Biomarkers. 2009 Sep;14(6):388-94.
31. Early reaction of astroglial cells in rat hippocampus to streptozotocin-induced diabetes. Lebed YV, etal., Neurosci Lett. 2008 Oct 24;444(2):181-5. Epub 2008 Aug 8.
32. Elevated serum S100B levels in acute spinal fracture without head injury. Lee SJ, etal., Emerg Med J. 2010 Mar;27(3):209-12.
33. Oral Uncaria rhynchophylla (UR) reduces kainic acid-induced epileptic seizures and neuronal death accompanied by attenuating glial cell proliferation and S100B proteins in rats. Lin YW and Hsieh CL, J Ethnopharmacol. 2011 May 17;135(2):313-20. Epub 2011 Mar 21.
34. SNPs and haplotypes in the S100B gene reveal association with schizophrenia. Liu J, etal., Biochem Biophys Res Commun. 2005 Mar 4;328(1):335-41. doi: 10.1016/j.bbrc.2004.12.175.
35. Novel interaction of the dopamine D2 receptor and the Ca2+ binding protein S100B: role in D2 receptor function. Liu Y, etal., Mol Pharmacol. 2008 Aug;74(2):371-8. Epub 2008 Apr 29.
36. Increased cerebrospinal fluid levels of S100B protein in rat model of mania induced by ouabain. Machado-Vieira R, etal., Life Sci. 2004 Dec 31;76(7):805-11.
37. Increased S100B serum levels in dilated cardiomyopathy patients. Mazzini GS, etal., J Card Fail. 2007 Dec;13(10):850-4.
38. The zinc- and calcium-binding S100B interacts and co-localizes with IQGAP1 during dynamic rearrangement of cell membranes. Mbele GO, etal., J Biol Chem 2002 Dec 20;277(51):49998-50007.
39. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
40. Overexpression of human S100B exacerbates cerebral amyloidosis and gliosis in the Tg2576 mouse model of Alzheimer's disease. Mori T, etal., Glia. 2010 Feb;58(3):300-14.
41. Effects of antibodies against protein S100b on synaptic transmission and long-term potentiation in CA-1 hippocampal neurons in rats. Motin VG, etal., Bull Exp Biol Med. 2002 Feb;133(2):110-3.
42. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
43. Vitamin D and calcium co-therapy mitigates pre-established cadmium nephropathy by regulating renal calcium homeostatic molecules and improving anti-oxidative and anti-inflammatory activities in rat. Obaid AA, etal., J Trace Elem Med Biol. 2023 May 24;79:127221. doi: 10.1016/j.jtemb.2023.127221.
44. Downregulation of an astrocyte-derived inflammatory protein, S100B, reduces vascular inflammatory responses in brains persistently infected with Borna disease virus. Ohtaki N, etal., J Virol. 2007 Jun;81(11):5940-8. Epub 2007 Mar 21.
45. Biochemical brain markers and purinergic parameters in rat CSF after seizure induced by pentylenetetrazol. Oses JP, etal., Brain Res Bull. 2004 Sep 30;64(3):237-42.
46. Circulating S100B is increased after bilateral femur fracture without brain injury in the rat. Pelinka LE, etal., Br J Anaesth. 2003 Oct;91(4):595-7.
47. Markers for different glial cell responses in multiple sclerosis: clinical and pathological correlations. Petzold A, etal., Brain. 2002 Jul;125(Pt 7):1462-73.
48. Neuronal and glial cerebrospinal fluid protein biomarkers are elevated after West Nile virus infection. Petzold A, etal., Muscle Nerve. 2010 Jan;41(1):42-9.
49. Regulation of S100B gene in rat hippocampal CA1 area during long term potentiation. Pustylnyak VO, etal., Brain Res. 2011 Jun 7;1394:33-9. Epub 2011 Apr 20.
50. Increased serum S100B levels in chronic schizophrenic patients on long-term clozapine or typical antipsychotics. Qi LY, etal., Neurosci Lett. 2009 Sep 22;462(2):113-7. Epub 2009 Jun 17.
51. GOA pipeline RGD automated data pipeline
52. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
53. Treadmill training restores spatial cognitive deficits and neurochemical alterations in the hippocampus of rats submitted to an intracerebroventricular administration of streptozotocin. Rodrigues L, etal., J Neural Transm. 2010 Nov;117(11):1295-305. Epub 2010 Oct 16.
54. PSAPP mice exhibit regionally selective reductions in gliosis and plaque deposition in response to S100B ablation. Roltsch E, etal., J Neuroinflammation. 2010 Nov 16;7:78.
55. RAGE-TXNIP axis is required for S100B-promoted Schwann cell migration, fibronectin expression and cytokine secretion. Sbai O, etal., J Cell Sci. 2010 Dec 15;123(Pt 24):4332-9. Epub 2010 Nov 23.
56. Calcium, troponin, calmodulin, S100 proteins: from myocardial basics to new therapeutic strategies. Schaub MC and Heizmann CW, Biochem Biophys Res Commun. 2008 Apr 25;369(1):247-64. Epub 2007 Oct 25.
57. Antisense inhibition of glial S100 beta production results in alterations in cell morphology, cytoskeletal organization, and cell proliferation. Selinfreund RH, etal., J Cell Biol. 1990 Nov;111(5 Pt 1):2021-8.
58. The danger signal S100B integrates pathogen- and danger-sensing pathways to restrain inflammation. Sorci G, etal., PLoS Pathog. 2011 Mar;7(3):e1001315. Epub 2011 Mar 10.
59. Neurofilaments in blood and CSF for diagnosis and prediction of onset in Creutzfeldt-Jakob disease. Steinacker P, etal., Sci Rep. 2016 Dec 8;6:38737. doi: 10.1038/srep38737.
60. Serum S100B is a useful surrogate marker for long-term outcomes in photochemically-induced thrombotic stroke rat models. Tanaka Y, etal., Life Sci. 2007 Aug 2;81(8):657-63. Epub 2007 Jul 21.
61. Developmental changes in S100B content in brain tissue, cerebrospinal fluid, and astrocyte cultures of rats. Tramontina F, etal., Cell Mol Neurobiol 2002 Jun;22(3):373-8.
62. Regulation of the S100B gene by alpha 1-adrenergic stimulation in cardiac myocytes. Tsoporis JN, etal., Am J Physiol Heart Circ Physiol 2003 Jan;284(1):H193-203.
63. S100B interaction with the receptor for advanced glycation end products (RAGE): a novel receptor-mediated mechanism for myocyte apoptosis postinfarction. Tsoporis JN, etal., Circ Res. 2010 Jan 8;106(1):93-101. Epub 2009 Nov 12.
64. S100B protein in myoblasts modulates myogenic differentiation via NF-kappaB-dependent inhibition of MyoD expression. Tubaro C, etal., J Cell Physiol. 2010 Apr;223(1):270-82.
65. Increased receptor for advanced glycation end product expression in the human alcoholic prefrontal cortex is linked to adolescent drinking. Vetreno RP, etal., Neurobiol Dis. 2013 Nov;59:52-62. doi: 10.1016/j.nbd.2013.07.002. Epub 2013 Jul 15.
66. Object-based analysis of astroglial reaction and astrocyte subtype morphology after ischemic brain injury. Wagner DC, etal., Acta Neurobiol Exp (Wars). 2013;73(1):79-87.
67. Neuroprotective effects of caffeic acid phenethyl ester against sevoflurane‑induced neuronal degeneration in the hippocampus of neonatal rats involve MAPK and PI3K/Akt signaling pathways. Wang LY, etal., Mol Med Rep. 2016 Oct;14(4):3403-12. doi: 10.3892/mmr.2016.5586. Epub 2016 Aug 4.
68. Combined prediction of miR-210 and miR-374a for severity and prognosis of hypoxic-ischemic encephalopathy. Wang Z, etal., Brain Behav. 2017 Dec 30;8(1):e00835. doi: 10.1002/brb3.835. eCollection 2018 Jan.
69. Location of the Zn(2+)-binding site on S100B as determined by NMR spectroscopy and site-directed mutagenesis. Wilder PT, etal., Biochemistry. 2003 Nov 25;42(46):13410-21. doi: 10.1021/bi035334q.
70. Solution structure of zinc- and calcium-bound rat S100B as determined by nuclear magnetic resonance spectroscopy. Wilder PT, etal., Biochemistry. 2005 Apr 19;44(15):5690-702.
71. Refinement of the solution structure and dynamic properties of Ca(2+)-bound rat S100B. Wright NT, etal., J Biomol NMR. 2008 Dec;42(4):279-86. Epub 2008 Oct 24.
72. Expression of S100 protein family members in the pathogenesis of bladder tumors. Yao R, etal., Anticancer Res. 2007 Sep-Oct;27(5A):3051-8.
73. Brain-derived neurotrophic factor (BDNF) infusion restored astrocytic plasticity in the hippocampus of a rat model of depression. Ye Y, etal., Neurosci Lett. 2011 Sep 26;503(1):15-9. Epub 2011 Aug 6.
74. Elevated S100B and neuron specific enolase levels in patients with migraine-without aura: evidence for neurodegeneration? Yilmaz N, etal., Cell Mol Neurobiol. 2011 May;31(4):579-85. Epub 2011 Feb 4.
75. Risk variants in the S100B gene, associated with elevated S100B levels, are also associated with visuospatial disability of schizophrenia. Zhai J, etal., Behav Brain Res. 2011 Mar 1;217(2):363-8. Epub 2010 Nov 9.
76. Serum concentrations of NSE and S100B in spinocerebellar ataxia type 3/Machado-Joseph disease. Zhou J, etal., Zhong Nan Da Xue Xue Bao Yi Xue Ban. 2011 Jun;36(6):504-10.
77. The usefulness of S100B, NSE, GFAP, NF-H, secretagogin and Hsp70 as a predictive biomarker of outcome in children with traumatic brain injury. Zurek J and Fedora M, Acta Neurochir (Wien). 2011 Oct 7.
Additional References at PubMed
PMID:1653388   PMID:3818655   PMID:6093041   PMID:8794737   PMID:9485423   PMID:9519411   PMID:10211826   PMID:10913138   PMID:11891290   PMID:12042313   PMID:12045670   PMID:12118070  
PMID:12470955   PMID:12477932   PMID:12744484   PMID:12941779   PMID:14736868   PMID:15033494   PMID:15076760   PMID:15248193   PMID:15489334   PMID:15566955   PMID:15567475   PMID:15572370  
PMID:15584905   PMID:15782413   PMID:15809219   PMID:15882069   PMID:15921704   PMID:16194580   PMID:16524173   PMID:16600520   PMID:16633903   PMID:17234709   PMID:17350141   PMID:17403138  
PMID:17499767   PMID:17660747   PMID:17729158   PMID:17880365   PMID:18472341   PMID:18602402   PMID:18621038   PMID:19027832   PMID:19137572   PMID:19559073   PMID:19726345   PMID:19823932  
PMID:20027335   PMID:20437086   PMID:20728493   PMID:21130124   PMID:21614209   PMID:21830043   PMID:21892662   PMID:21970823   PMID:22052576   PMID:22627026   PMID:23561481   PMID:24239092  
PMID:24582971   PMID:24766228   PMID:24770897   PMID:24842050   PMID:25129106   PMID:25416956   PMID:25433207   PMID:25682687   PMID:25898931   PMID:26246400   PMID:26773687   PMID:26782580  
PMID:26871637   PMID:27107012   PMID:27301641   PMID:27488079   PMID:27660208   PMID:27695124   PMID:27928847   PMID:28693920   PMID:28713206   PMID:29050939   PMID:29130118   PMID:29664924  
PMID:29684040   PMID:31038022   PMID:32491925   PMID:33232757   PMID:34045267   PMID:34051593   PMID:34680103   PMID:34792689   PMID:37384931  


Genomics

Comparative Map Data
S100b
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr82012,372,345 - 12,381,159 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl2012,372,348 - 12,381,081 (-)EnsemblGRCr8
mRatBN7.22012,372,866 - 12,381,619 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl2012,372,881 - 12,394,743 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx2013,071,830 - 13,080,530 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.02012,432,755 - 12,441,455 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.02012,904,538 - 12,913,238 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.02013,130,633 - 13,142,856 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl2013,130,636 - 13,142,856 (-)Ensemblrn6Rnor6.0
Rnor_5.02015,287,745 - 15,296,485 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.42012,791,440 - 12,824,508 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera2013,867,276 - 13,875,895 (-)NCBICelera
RGSC_v3.12012,791,666 - 12,824,735 (-)NCBI
Cytogenetic Map20p12NCBI
S100B
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh382146,598,604 - 46,605,082 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl2146,598,604 - 46,605,208 (-)Ensemblhg38GRCh38
GRCh372148,018,517 - 48,024,995 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 362146,842,959 - 46,849,463 (-)NCBIBuild 36Build 36hg18NCBI36
Build 342146,842,958 - 46,849,424NCBI
Celera2133,131,698 - 33,138,202 (-)NCBICelera
Cytogenetic Map21q22.3NCBI
HuRef2133,398,429 - 33,404,960 (-)NCBIHuRef
CHM1_12147,579,370 - 47,585,892 (-)NCBICHM1_1
T2T-CHM13v2.02144,984,829 - 44,991,348 (-)NCBIT2T-CHM13v2.0
S100b
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391076,089,670 - 76,097,153 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1076,089,687 - 76,096,993 (+)EnsemblGRCm39 EnsemblGRCm39
GRCm381076,253,836 - 76,261,319 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1076,253,853 - 76,261,159 (+)Ensemblmm10GRCm38
MGSCv371075,716,581 - 75,724,064 (+)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv361075,697,569 - 75,703,813 (+)NCBIMGSCv36mm8
Celera1077,297,763 - 77,305,246 (+)NCBICelera
Cytogenetic Map10C1NCBI
cM Map1038.76NCBI
S100b
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495540742,972,584 - 42,980,510 (-)Ensembl
ChiLan1.0NW_00495540742,972,584 - 42,980,510 (-)NCBIChiLan1.0ChiLan1.0
S100B
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v22242,780,225 - 42,786,453 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan12137,589,861 - 37,596,083 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v02133,063,845 - 33,070,073 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.12146,197,750 - 46,203,953 (-)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl2146,197,750 - 46,203,953 (-)EnsemblpanPan2panpan1.1
S100B
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.13139,783,990 - 39,788,289 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl3139,784,506 - 39,788,183 (-)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha3139,014,186 - 39,018,506 (-)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.03139,427,666 - 39,431,986 (-)NCBIROS_Cfam_1.0ROS_Cfam_1.0
UMICH_Zoey_3.13139,288,949 - 39,293,268 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.03139,249,760 - 39,254,080 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.03139,768,041 - 39,772,361 (-)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
S100B
(Sus scrofa - pig)		 No map positions available.
S100B
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1290,188,820 - 90,194,986 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl290,188,639 - 90,195,023 (-)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Vero_WHO_p1.0NW_02366605418,611,924 - 18,618,244 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
S100b
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462474531,645,927 - 31,652,832 (-)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
HetGla 1.0NW_00462474531,645,927 - 31,652,846 (-)NCBIHetGla 1.0HetGla 1.0hetGla2

Variants

.
Variants in S100b
119 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:102
Count of miRNA genes:86
Interacting mature miRNAs:92
Transcripts:ENSRNOT00000001743
Prediction methods:Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
4889870Pur30Proteinuria QTL 30190.005urine total protein amount (VT:0000032)urine total protein excretion rate (CMO:0000756)20804241029322208Rat
1354642Despr15Despair related QTL 150.0027locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)20124159021Rat
4889857Pur27Proteinuria QTL 2712.20.001urine total protein amount (VT:0000032)urine total protein excretion rate (CMO:0000756)20460660717617956Rat
70154Insul2Insulin level QTL 23.75blood insulin amount (VT:0001560)plasma insulin level (CMO:0000342)20669170617489458Rat
9590109Sffal8Serum free fatty acids level QTL 85.320.01blood free fatty acid amount (VT:0001553)plasma free fatty acids level (CMO:0000546)20129191651Rat
9590275Scort15Serum corticosterone level QTL 153.480.001blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)20129191651Rat
1581577Pur15Proteinuria QTL 154.380.0002urine total protein amount (VT:0000032)urine protein excretion rate (CMO:0000759)20804241017617956Rat
6893685Bw111Body weight QTL 1112.70.004body mass (VT:0001259)body weight (CMO:0000012)20132578807Rat
9590092Insglur9Insulin/glucose ratio QTL 918.380.001blood insulin amount (VT:0001560)calculated plasma insulin level (CMO:0002170)201175751554435887Rat
1641915Colcr9Colorectal carcinoma resistance QTL 92.970.0024intestine integrity trait (VT:0010554)benign colorectal tumor number (CMO:0001795)20153065546530655Rat
2317057Aia27Adjuvant induced arthritis QTL 272.83joint integrity trait (VT:0010548)right rear ankle joint diameter (CMO:0002150)20289259726381954Rat
7387283Uae44Urinary albumin excretion QTL 440.1712urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)20126123605Rat
7411668Foco32Food consumption QTL 3280.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)20136600972Rat
2305926Iddm37Insulin dependent diabetes mellitus QTL 376blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)20152784246527842Rat
1600382Edcs3Endometrial carcinoma susceptibility QTL33.50.003uterus morphology trait (VT:0001120)percentage of study population developing endometrioid carcinoma during a period of time (CMO:0001759)20125159026Rat
1558640Prcs2Prostate cancer susceptibility QTL 23.3prostate integrity trait (VT:0010571)percentage of study population developing ventral prostate tumorous lesions during a period of time (CMO:0000943)20460660717617956Rat
631265Iresp1Immunoglobin response QTL18.3blood anti-double stranded DNA antibody amount (VT:0004762)serum anti-DNA antibody level (CMO:0001533)20903971913461775Rat
8694189Bw153Body weight QTL 1533.130.001body mass (VT:0001259)body weight gain (CMO:0000420)20129191651Rat
9589155Insul32Insulin level QTL 326.380.001blood insulin amount (VT:0001560)plasma insulin level (CMO:0000342)20129191651Rat
7411650Foco23Food consumption QTL 2320.70.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)20129191651Rat
7411652Foco24Food consumption QTL 240.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)201175751554435887Rat
2317851Alcrsp22Alcohol response QTL 223.20.05response to alcohol trait (VT:0010489)duration of loss of righting reflex (CMO:0002289)20127339237Rat
1598816Memor12Memory QTL 122.4exploratory behavior trait (VT:0010471)average horizontal distance between subject and target during voluntary locomotion in an experimental apparatus (CMO:0002674)20260683647606836Rat
61432Cia1Collagen induced arthritis QTL 1joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)20362165614101050Rat
1641893Alcrsp7Alcohol response QTL 7response to alcohol trait (VT:0010489)duration of loss of righting reflex (CMO:0002289)20127339237Rat
9590252Scort12Serum corticosterone level QTL 1220.460.001blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)20136600972Rat

Markers in Region
D20Wox6  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.22012,374,046 - 12,374,191 (+)MAPPERmRatBN7.2
Rnor_6.02013,131,801 - 13,131,945NCBIRnor6.0
Rnor_5.02015,288,913 - 15,289,057UniSTSRnor5.0
RGSC_v3.42012,792,605 - 12,792,749UniSTSRGSC3.4
Celera2013,868,441 - 13,868,585UniSTS
Cytogenetic Map20p12UniSTS
RH94706  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.22012,373,324 - 12,373,504 (+)MAPPERmRatBN7.2
Rnor_6.02013,131,079 - 13,131,258NCBIRnor6.0
Rnor_5.02015,288,191 - 15,288,370UniSTSRnor5.0
RGSC_v3.42012,791,883 - 12,792,062UniSTSRGSC3.4
Celera2013,867,719 - 13,867,898UniSTS
Cytogenetic Map20p12UniSTS
AA945753  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.22012,420,339 - 12,420,435 (+)MAPPERmRatBN7.2
Rnor_6.02013,212,310 - 13,212,405NCBIRnor6.0
Rnor_5.02015,366,644 - 15,366,739UniSTSRnor5.0
RGSC_v3.42012,816,715 - 12,816,810UniSTSRGSC3.4
Celera2013,914,039 - 13,914,134UniSTS
Cytogenetic Map20p12UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
10 12 63 156 89 88 57 62 57 6 305 158 11 135 72 89 31 14 14

Sequence

Nucleotide Sequences
RefSeq Transcripts NM_013191 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_008772868 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017601568 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063278986 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide BC087026 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH473988 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ212122 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ213381 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ213618 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ213687 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ213774 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ213840 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ214218 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ214292 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ214486 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ214554 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JAXUCZ010000020 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  M15705 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  M54919 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  X01090 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Ensembl Acc Id: ENSRNOT00000001743   ⟹   ENSRNOP00000001743
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl2012,372,348 - 12,381,081 (-)Ensembl
mRatBN7.2 Ensembl2012,372,881 - 12,381,781 (-)Ensembl
Rnor_6.0 Ensembl2013,130,636 - 13,142,856 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000096333   ⟹   ENSRNOP00000085085
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl2012,373,163 - 12,394,743 (-)Ensembl
RefSeq Acc Id: NM_013191   ⟹   NP_037323
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr82012,372,348 - 12,381,081 (-)NCBI
mRatBN7.22012,372,882 - 12,381,619 (-)NCBI
Rnor_6.02013,130,636 - 13,142,856 (-)NCBI
Rnor_5.02015,287,745 - 15,296,485 (-)NCBI
RGSC_v3.42012,791,440 - 12,824,508 (-)RGD
Celera2013,867,276 - 13,875,895 (-)RGD
Sequence:
RefSeq Acc Id: XM_008772868   ⟹   XP_008771090
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr82012,372,345 - 12,381,159 (-)NCBI
mRatBN7.22012,372,866 - 12,381,538 (-)NCBI
Rnor_6.02013,130,633 - 13,137,526 (-)NCBI
Sequence:
RefSeq Acc Id: XM_017601568   ⟹   XP_017457057
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr82012,372,345 - 12,381,108 (-)NCBI
mRatBN7.22012,372,866 - 12,381,473 (-)NCBI
Rnor_6.02013,130,633 - 13,142,854 (-)NCBI
Sequence:
RefSeq Acc Id: XM_063278986   ⟹   XP_063135056
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr82012,372,345 - 12,381,010 (-)NCBI
RefSeq Acc Id: NP_037323   ⟸   NM_013191
- UniProtKB: P04631 (UniProtKB/Swiss-Prot),   A6JKD9 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_008771090   ⟸   XM_008772868
- Peptide Label: isoform X1
- UniProtKB: P04631 (UniProtKB/Swiss-Prot),   A6JKD9 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_017457057   ⟸   XM_017601568
- Peptide Label: isoform X1
- UniProtKB: P04631 (UniProtKB/Swiss-Prot),   A6JKD9 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000001743   ⟸   ENSRNOT00000001743
Ensembl Acc Id: ENSRNOP00000085085   ⟸   ENSRNOT00000096333
RefSeq Acc Id: XP_063135056   ⟸   XM_063278986
- Peptide Label: isoform X1
- UniProtKB: P04631 (UniProtKB/Swiss-Prot),   A6JKD9 (UniProtKB/TrEMBL)
Protein Domains
EF-hand

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P04631-F1-model_v2 AlphaFold P04631 1-92 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13701520
Promoter ID:EPDNEW_R12044
Type:multiple initiation site
Name:S100b_1
Description:S100 calcium binding protein B
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.02013,142,798 - 13,142,858EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:3615 AgrOrtholog
BioCyc Gene G2FUF-4185 BioCyc
Ensembl Genes ENSRNOG00000001295 Ensembl, ENTREZGENE
Ensembl Transcript ENSRNOT00000001743 ENTREZGENE
Gene3D-CATH EF-hand UniProtKB/Swiss-Prot
IMAGE_CLONE IMAGE:7193740 IMAGE-MGC_LOAD
InterPro EF-hand-dom_pair UniProtKB/Swiss-Prot
  EF_Hand_1_Ca_BS UniProtKB/Swiss-Prot
  EF_hand_dom UniProtKB/Swiss-Prot
  S100-B UniProtKB/Swiss-Prot
  S100/CaBP-9k_CS UniProtKB/Swiss-Prot
  S100_Ca-bd_sub UniProtKB/Swiss-Prot
KEGG Report rno:25742 UniProtKB/Swiss-Prot
MGC_CLONE MGC:93559 IMAGE-MGC_LOAD
NCBI Gene 25742 ENTREZGENE
PANTHER PROTEIN S100-A1-RELATED UniProtKB/Swiss-Prot
  S100 CALCIUM-BINDING PROTEIN UniProtKB/Swiss-Prot
Pfam EF-hand_1 UniProtKB/Swiss-Prot
  S_100 UniProtKB/Swiss-Prot
PhenoGen S100b PhenoGen
PROSITE EF_HAND_1 UniProtKB/Swiss-Prot
  EF_HAND_2 UniProtKB/Swiss-Prot
  S100_CABP UniProtKB/Swiss-Prot
RatGTEx ENSRNOG00000001295 RatGTEx
SMART EFh UniProtKB/Swiss-Prot
  S_100 UniProtKB/Swiss-Prot
Superfamily-SCOP SSF47473 UniProtKB/Swiss-Prot
UniProt A0A8I6A0X7_RAT UniProtKB/TrEMBL
  A0A8L2PZQ2_RAT UniProtKB/TrEMBL
  A6JKD9 ENTREZGENE, UniProtKB/TrEMBL
  A6JKE0_RAT UniProtKB/TrEMBL
  P04631 ENTREZGENE, UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2008-09-18 S100b  S100 calcium binding protein B  S100b  S100 protein, beta polypeptide, neural  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-02-18 S100b  S100 protein, beta polypeptide, neural  S100b  S100 protein, beta polypeptide  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2002-06-10 S100b  S100 calcium-binding protein, beta (neural)      Symbol and Name status set to approved 70586 APPROVED

RGD Curation Notes
Note Type Note Reference
gene_cellular_localization colocalizes to membrane ruffles with GTPase activating protein IQGAP 727451
gene_expression expressed in the brain astrocytes and mRNA was detected in the rat heart after coronary artery ligation 628549
gene_process inhibits postinfarct myocardial hypertrophic response 628549
gene_protein 20 kDa calcium binding homodimer 628549
gene_regulation activation of the promoter is mediated through the PKC signalling pathway 628549