Ring1 (ring finger protein 1) - Rat Genome Database

Name: Ring1
Creator: Rat Genome Database
License: Creative Commons CC BY 4.0
Keywords: Rat Gene RGD Genome

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Gene: Ring1 (ring finger protein 1) Rattus norvegicus

Analyze

Symbol:

Ring1

Name:

ring finger protein 1

RGD ID:

3576

Description:

Predicted to enable chromatin binding activity; ubiquitin protein ligase activity; and ubiquitin-protein transferase activator activity. Predicted to be involved in chromatin remodeling; histone H2A monoubiquitination; and negative regulation of DNA-templated transcription. Predicted to act upstream of or within several processes, including anterior/posterior pattern specification; camera-type eye morphogenesis; and histone ubiquitination. Predicted to be located in cytosol; nuclear body; and sex chromatin. Predicted to be part of PRC1 complex. Orthologous to human RING1 (ring finger protein 1); PARTICIPATES IN histone modification pathway; INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 2,6-dinitrotoluene; 4,4'-sulfonyldiphenol.

Type:

protein-coding

RefSeq Status:

VALIDATED

Previously known as:

E3 ubiquitin-protein ligase RING1; MGC112563; polycomb complex protein RING1; RING-type E3 ubiquitin transferase RING1; Ring1A

RGD Orthologs

Human

Mouse

Chinchilla

Bonobo

Dog

Squirrel

Pig

Green Monkey

Naked Mole-Rat

Alliance Genes

More Info

more info ...

More Info

Species	Gene symbol and name	Data Source	Assertion derived from	less info ...
Orthologs ¹				less info ...
Homo sapiens (human):	RING1 (ring finger protein 1)	HGNC	Ensembl, HomoloGene, Inparanoid, NCBI, OrthoDB, OrthoMCL, Panther, PhylomeDB, Treefam
Mus musculus (house mouse):	Ring1 (ring finger protein 1)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chinchilla lanigera (long-tailed chinchilla):	Ring1 (ring finger protein 1)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Pan paniscus (bonobo/pygmy chimpanzee):	RING1 (ring finger protein 1)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Canis lupus familiaris (dog):	RING1 (ring finger protein 1)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Ictidomys tridecemlineatus (thirteen-lined ground squirrel):	Ring1 (ring finger protein 1)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Sus scrofa (pig):	RING1 (ring finger protein 1)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chlorocebus sabaeus (green monkey):	RING1 (ring finger protein 1)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Heterocephalus glaber (naked mole-rat):	Ring1 (ring finger protein 1)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Alliance orthologs ³
Mus musculus (house mouse):	Ring1 (ring finger protein 1)	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Homo sapiens (human):	RING1 (ring finger protein 1)	Alliance	DIOPT (Ensembl Compara\|HGNC\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Drosophila melanogaster (fruit fly):	Sce	Alliance	DIOPT (Ensembl Compara\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|SonicParanoid)
Caenorhabditis elegans (roundworm):	spat-3	Alliance	DIOPT (OrthoFinder\|OrthoInspector\|PANTHER)

Latest Assembly:

mRatBN7.2 - mRatBN7.2 Assembly

Position:

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
mRatBN7.2	20	4,830,120 - 4,833,623 (+)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	20	4,830,053 - 4,833,620 (+)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	20	5,581,912 - 5,585,405 (+)	NCBI	Rnor_SHR
UTH_Rnor_SHRSP_BbbUtx_1.0	20	4,943,666 - 4,947,159 (+)	NCBI	Rnor_SHRSP
UTH_Rnor_WKY_Bbb_1.0	20	5,424,543 - 5,428,055 (+)	NCBI	Rnor_WKY
Rnor_6.0	20	3,812,287 - 3,815,834 (-)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	20	3,812,287 - 3,815,834 (-)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	20	5,891,721 - 5,895,165 (-)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	20	4,968,251 - 4,972,149 (+)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
Celera	20	6,430,305 - 6,433,771 (+)	NCBI		Celera
Cytogenetic Map	20	p12	NCBI

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

autosomal dominant intellectual developmental disorder 5 (ISO)

genetic disease (ISO)

JMP syndrome (ISO)

Gene-Chemical Interaction Annotations Click to see Annotation Detail View

(+)-catechin (ISO)

17alpha-ethynylestradiol (ISO)

2,3,7,8-tetrachlorodibenzodioxine (EXP,ISO)

2,6-dinitrotoluene (EXP)

3,4-methylenedioxymethamphetamine (ISO)

4,4'-sulfonyldiphenol (EXP)

ammonium chloride (EXP)

amphetamine (EXP)

aristolochic acid A (ISO)

benzo[a]pyrene (ISO)

bisphenol A (EXP,ISO)

bisphenol F (EXP)

cadmium atom (ISO)

caffeine (ISO)

cisplatin (ISO)

cobalt dichloride (ISO)

cocaine (EXP)

cyclophosphamide (EXP)

diazinon (ISO)

disodium selenite (ISO)

doxorubicin (ISO)

elemental selenium (ISO)

fenvalerate (EXP)

folic acid (ISO)

fulvestrant (ISO)

ivermectin (ISO)

methyl methanesulfonate (ISO)

methylmercury chloride (ISO)

morphine (EXP)

paracetamol (EXP)

quercetin (ISO)

selenium atom (ISO)

senecionine (ISO)

sodium arsenite (ISO)

tetrachloroethene (ISO)

trichloroethene (EXP)

venlafaxine hydrochloride (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

anterior/posterior pattern specification (ISO)

biological_process (ND)

camera-type eye morphogenesis (ISO)

chromatin organization (ISO)

chromatin remodeling (ISO)

histone H2A monoubiquitination (IBA,IEA)

negative regulation of DNA-templated transcription (IBA,ISO)

Cellular Component

cellular_component (ND)

cytosol (IEA,ISO)

nuclear body (ISO)

nuclear speck (IEA)

nucleoplasm (ISO)

nucleus (IEA,ISO)

PcG protein complex (IBA,ISO,ISS)

PRC1 complex (ISO,ISS)

sex chromatin (ISO)

ubiquitin ligase complex (IBA,IEA)

Molecular Function

chromatin binding (IBA,ISO)

metal ion binding (IEA)

molecular_function (ND)

protein binding (ISO)

ubiquitin protein ligase activity (IBA)

ubiquitin-protein transferase activator activity (ISO)

Molecular Pathway Annotations Click to see Annotation Detail View

histone modification pathway (ISO)

References

References - curated

#	Reference Title	Reference Citation
1.	Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium.	Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2.	PRC1 complex diversity: where is it taking us?	Gil J and O'Loghlen A, Trends Cell Biol. 2014 Jul 22. pii: S0962-8924(14)00102-0. doi: 10.1016/j.tcb.2014.06.005.
3.	The genomic sequence and comparative analysis of the rat major histocompatibility complex.	Hurt P, etal., Genome Res 2004 Apr;14(4):631-9.
4.	Rat ISS GO annotations from MGI mouse gene data--August 2006	MGD data from the GO Consortium
5.	Data Import for Chemical-Gene Interactions	RGD automated import pipeline for gene-chemical interactions
6.	Comprehensive gene review and curation	RGD comprehensive gene curation
7.	Occupying chromatin: Polycomb mechanisms for getting to genomic targets, stopping transcriptional traffic, and staying put.	Simon JA and Kingston RE, Mol Cell. 2013 Mar 7;49(5):808-24. doi: 10.1016/j.molcel.2013.02.013.

Additional References at PubMed

PMID:8662089	PMID:9199346	PMID:9312051	PMID:10970097	PMID:11060235	PMID:12167701	PMID:12183370	PMID:12477932	PMID:15489334	PMID:15525528	PMID:16359901	PMID:16624538
PMID:16687444	PMID:16943429	PMID:19636380	PMID:21282530	PMID:21501682	PMID:28032293

Genomics

Comparative Map Data

Ring1
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
mRatBN7.2	20	4,830,120 - 4,833,623 (+)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	20	4,830,053 - 4,833,620 (+)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	20	5,581,912 - 5,585,405 (+)	NCBI	Rnor_SHR
UTH_Rnor_SHRSP_BbbUtx_1.0	20	4,943,666 - 4,947,159 (+)	NCBI	Rnor_SHRSP
UTH_Rnor_WKY_Bbb_1.0	20	5,424,543 - 5,428,055 (+)	NCBI	Rnor_WKY
Rnor_6.0	20	3,812,287 - 3,815,834 (-)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	20	3,812,287 - 3,815,834 (-)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	20	5,891,721 - 5,895,165 (-)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	20	4,968,251 - 4,972,149 (+)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
Celera	20	6,430,305 - 6,433,771 (+)	NCBI		Celera
Cytogenetic Map	20	p12	NCBI

RING1
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	6	33,208,500 - 33,212,716 (+)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p13 Ensembl	6	33,208,500 - 33,212,722 (+)	Ensembl	GRCh38		hg38	GRCh38
GRCh37	6	33,176,277 - 33,180,493 (+)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	6	33,284,264 - 33,288,477 (+)	NCBI	NCBI36	Build 36	hg18	NCBI36
Build 34	6	33,284,263 - 33,288,476	NCBI
Celera	6	34,730,650 - 34,734,863 (+)	NCBI		Celera
Cytogenetic Map	6	p21.32	NCBI
HuRef	6	32,918,331 - 32,922,544 (+)	NCBI		HuRef
CHM1_1	6	33,178,164 - 33,182,377 (+)	NCBI		CHM1_1
T2T-CHM13v2.0	6	33,029,853 - 33,034,069 (+)	NCBI		T2T-CHM13v2.0

Ring1
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	17	34,239,766 - 34,243,654 (-)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	17	34,239,766 - 34,243,654 (-)	Ensembl		GRCm39 Ensembl
GRCm38	17	34,020,792 - 34,024,680 (-)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	17	34,020,792 - 34,024,680 (-)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	17	34,157,737 - 34,161,625 (-)	NCBI	GRCm37	MGSCv37	mm9	NCBIm37
MGSCv36	17	33,631,538 - 33,635,097 (-)	NCBI		MGSCv36	mm8
Celera	17	36,766,927 - 36,770,809 (-)	NCBI		Celera
Cytogenetic Map	17	B1	NCBI

Ring1
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955437	1,782,115 - 1,788,842 (+)	Ensembl	ChiLan1.0
ChiLan1.0	NW_004955437	1,782,156 - 1,785,811 (+)	NCBI	ChiLan1.0	ChiLan1.0

RING1
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
PanPan1.1	6	33,895,631 - 33,899,734 (+)	NCBI	panpan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	6	33,895,849 - 33,899,417 (+)	Ensembl	panpan1.1		panPan2
Mhudiblu_PPA_v0	6	32,780,699 - 32,784,922 (+)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3

RING1
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	12	2,671,578 - 2,675,488 (+)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	12	2,671,578 - 2,675,488 (+)	Ensembl	CanFam3.1		canFam3	CanFam3.1
Dog10K_Boxer_Tasha	12	2,752,719 - 2,756,629 (+)	NCBI		Dog10K_Boxer_Tasha
ROS_Cfam_1.0	12	3,002,311 - 3,006,226 (+)	NCBI		ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	12	3,002,311 - 3,006,226 (+)	Ensembl		ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	12	2,670,496 - 2,674,406 (+)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	12	2,751,860 - 2,755,773 (+)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	12	2,826,435 - 2,830,348 (+)	NCBI		UU_Cfam_GSD_1.0

Ring1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024404946	38,313,317 - 38,317,138 (+)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936476	25,642,411 - 25,647,202 (-)	Ensembl	SpeTri2.0
SpeTri2.0	NW_004936476	25,643,129 - 25,646,928 (-)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

RING1
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	7	25,251,486 - 25,255,522 (+)	Ensembl	Sscrofa11.1		susScr11	Sscrofa11.1
Sscrofa11.1	7	25,251,507 - 25,255,526 (+)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	7	29,748,096 - 29,752,115 (-)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

RING1
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	17	38,862,411 - 38,866,631 (-)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	17	38,860,729 - 38,866,371 (-)	Ensembl	ChlSab1.1	ChlSab1.1 Ensembl	chlSab2
Vero_WHO_p1.0	NW_023666044	33,042,139 - 33,047,029 (+)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Ring1
(Heterocephalus glaber - naked mole-rat)

Naked Mole-rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624754	23,594,910 - 23,599,434 (-)	Ensembl	HetGla_female_1.0	HetGla_female_1.0 Ensembl	hetGla2
HetGla 1.0	NW_004624754	23,595,612 - 23,599,146 (-)	NCBI	HetGla_female_1.0	HetGla 1.0	hetGla2

Variants

Variants in Ring1
17 total Variants

miRNA Target Status

Predicted Target Of

	Summary Value
Count of predictions:	182
Count of miRNA genes:	120
Interacting mature miRNAs:	128
Transcripts:	ENSRNOT00000000543
Prediction methods:	Microtar, Miranda, Rnahybrid, Targetscan
Result types:	miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.

QTLs in Region (mRatBN7.2)

The following QTLs overlap with this region.

RGD ID	Symbol	Name	LOD	P Value	Trait	Sub Trait	Chr	Start	Stop	Species
1354642	Despr15	Despair related QTL 15		0.0027	locomotor behavior trait (VT:0001392)	amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)	20	1	24159021	Rat
1600382	Edcs3	Endometrial carcinoma susceptibility QTL3	3.5	0.003	uterus morphology trait (VT:0001120)	percentage of study population developing endometrioid carcinoma during a period of time (CMO:0001759)	20	1	25159026	Rat
2317851	Alcrsp22	Alcohol response QTL 22	3.2	0.05	response to alcohol trait (VT:0010489)	duration of loss of righting reflex (CMO:0002289)	20	1	27339237	Rat
1641893	Alcrsp7	Alcohol response QTL 7			response to alcohol trait (VT:0010489)	duration of loss of righting reflex (CMO:0002289)	20	1	27339237	Rat
8694189	Bw153	Body weight QTL 153	3.13	0.001	body mass (VT:0001259)	body weight gain (CMO:0000420)	20	1	29191651	Rat
9590275	Scort15	Serum corticosterone level QTL 15	3.48	0.001	blood corticosterone amount (VT:0005345)	plasma corticosterone level (CMO:0001173)	20	1	29191651	Rat
7411650	Foco23	Food consumption QTL 23	20.7	0.001	eating behavior trait (VT:0001431)	feed conversion ratio (CMO:0001312)	20	1	29191651	Rat
9590109	Sffal8	Serum free fatty acids level QTL 8	5.32	0.01	blood free fatty acid amount (VT:0001553)	plasma free fatty acids level (CMO:0000546)	20	1	29191651	Rat
9589155	Insul32	Insulin level QTL 32	6.38	0.001	blood insulin amount (VT:0001560)	plasma insulin level (CMO:0000342)	20	1	29191651	Rat
6893685	Bw111	Body weight QTL 111	2.7	0.004	body mass (VT:0001259)	body weight (CMO:0000012)	20	1	32578807	Rat
7411668	Foco32	Food consumption QTL 32	8	0.001	eating behavior trait (VT:0001431)	feed conversion ratio (CMO:0001312)	20	1	36600972	Rat
9590252	Scort12	Serum corticosterone level QTL 12	20.46	0.001	blood corticosterone amount (VT:0005345)	plasma corticosterone level (CMO:0001173)	20	1	36600972	Rat
2305926	Iddm37	Insulin dependent diabetes mellitus QTL 37	6		blood glucose amount (VT:0000188)	plasma glucose level (CMO:0000042)	20	1527842	46527842	Rat
2306850	Pia40	Pristane induced arthritis QTL 40		0.0001	joint integrity trait (VT:0010548)	joint inflammation composite score (CMO:0000919)	20	1527959	5304575	Rat
1641915	Colcr9	Colorectal carcinoma resistance QTL 9	2.97	0.0024	intestine integrity trait (VT:0010554)	benign colorectal tumor number (CMO:0001795)	20	1530655	46530655	Rat
1598816	Memor12	Memory QTL 12	2.4		exploratory behavior trait (VT:0010471)	average horizontal distance between subject and target during voluntary locomotion in an experimental apparatus (CMO:0002674)	20	2606836	47606836	Rat
2317057	Aia27	Adjuvant induced arthritis QTL 27	2.83		joint integrity trait (VT:0010548)	right rear ankle joint diameter (CMO:0002150)	20	2892597	26381954	Rat
1300152	Bp195	Blood pressure QTL 195	3.46		arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	20	3621649	9243559	Rat
1331772	Cdexp2	CD45RC expression in CD8 T cells QTL 2	5.7		CD8-positive T cell quantity (VT:0008077)	blood CD45RC(high) CD8 T cell count to CD45RC(low) CD8 T cell count ratio (CMO:0001990)	20	3621649	10078919	Rat
61432	Cia1	Collagen induced arthritis QTL 1			joint integrity trait (VT:0010548)	joint inflammation composite score (CMO:0000919)	20	3621656	14101050	Rat
61474	Eae1	Experimental allergic encephalomyelitis QTL 1	3		nervous system integrity trait (VT:0010566)	experimental autoimmune encephalomyelitis severity score (CMO:0001419)	20	4606607	6691706	Rat
4889857	Pur27	Proteinuria QTL 27	12.2	0.001	urine total protein amount (VT:0000032)	urine total protein excretion rate (CMO:0000756)	20	4606607	17617956	Rat
1558640	Prcs2	Prostate cancer susceptibility QTL 2	3.3		prostate integrity trait (VT:0010571)	percentage of study population developing ventral prostate tumorous lesions during a period of time (CMO:0000943)	20	4606607	17617956	Rat
7175096	Tcs1	T cell selection QTL 1			T cell selection	expression	20	4727078	5024580	Rat

Markers in Region

RH133333

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	20	4,828,458 - 4,828,652 (-)	MAPPER	mRatBN7.2
Rnor_6.0	20	3,817,302 - 3,817,495	NCBI	Rnor6.0
Rnor_5.0	20	5,896,633 - 5,896,826	UniSTS	Rnor5.0
RGSC_v3.4	20	4,966,573 - 4,966,766	UniSTS	RGSC3.4
Celera	20	6,428,644 - 6,428,837	UniSTS
RH 3.4 Map	20	59.7	UniSTS
Cytogenetic Map	20	p12	UniSTS

BF393858

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	20	4,830,711 - 4,830,851 (-)	MAPPER	mRatBN7.2
Rnor_6.0	20	3,815,103 - 3,815,242	NCBI	Rnor6.0
Rnor_5.0	20	5,894,434 - 5,894,573	UniSTS	Rnor5.0
RGSC_v3.4	20	4,968,826 - 4,968,965	UniSTS	RGSC3.4
Celera	20	6,430,897 - 6,431,036	UniSTS
RH 3.4 Map	20	61.1	UniSTS
Cytogenetic Map	20	p12	UniSTS

Expression

RNA-SEQ Expression

High: > 1000 TPM value Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM Below Cutoff: < 0.5 TPM

	alimentary part of gastrointestinal system	circulatory system	endocrine system	exocrine system	hemolymphoid system	hepatobiliary system	integumental system	musculoskeletal system	nervous system	renal system	reproductive system	respiratory system	appendage
High
Medium	3	35	49	33	13	33		3	66	32	41	11
Low		8	8	8	6	8	8	8	8	3			8
Below cutoff

View RNA-SEQ Expression Data

Sequence

Nucleotide Sequences


RefSeq Transcripts	NM_212549	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_017601640	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	AB568263	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	AC098547	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	AJ243579	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	BC098635	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	BX883042	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	CH473988	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	JACYVU010000324	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	X95474	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

Reference Sequences

RefSeq Acc Id:

ENSRNOT00000000543 ⟹ ENSRNOP00000000543

RefSeq Status:

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2 Ensembl	20	4,830,121 - 4,833,619 (+)	Ensembl
Rnor_6.0 Ensembl	20	3,812,287 - 3,815,834 (-)	Ensembl

RefSeq Acc Id:

ENSRNOT00000081085 ⟹ ENSRNOP00000073573

RefSeq Status:

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2 Ensembl	20	4,830,053 - 4,833,620 (+)	Ensembl
Rnor_6.0 Ensembl	20	3,812,287 - 3,813,673 (-)	Ensembl

RefSeq Acc Id:

NM_212549 ⟹ NP_997714

RefSeq Status:

VALIDATED

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2	20	4,830,120 - 4,833,623 (+)	NCBI
Rnor_6.0	20	3,812,287 - 3,815,834 (-)	NCBI
Rnor_5.0	20	5,891,721 - 5,895,165 (-)	NCBI
RGSC_v3.4	20	4,968,251 - 4,972,149 (+)	RGD
Celera	20	6,430,305 - 6,433,771 (+)	NCBI

Sequence:

show sequence

CGGGCCTCAGCGCCCGGGCCATGGCGGCGGCGGTGGCAGCAAGGGTTGCGGCGTGAGTGGCAGC
TACGGACCGAGCAGACCAGGGCGGCGGAGCCCCGGGGTCCCCGGGGAGAGGCCCGCAGTGGGGC
AGCGCGAAGGCCGGAGCCGGACCTCTCTCAGCGGAGCCCTGCTTGGAGGGGGTCGGTGCCCCGT
CGCCATGACGACGCCGGCGAATGCACAGAATGCCAGCAAAACGTGGGAACTGAGTCTCTATGAG
CTGCACCGGACCCCGCAGGAAGCCATCATGGACGGGACGGAGATTGCTGTTTCGCCCCGGTCAC
TGCATTCGGAGCTCATGTGCCCCATCTGCCTGGACATGCTGAAAAACACAATGACCACCAAGGA
ATGCTTGCACAGGTTCTGCTCGGACTGCATCGTCACTGCCCTGCGGAGCGGGAACAAAGAGTGC
CCCACCTGCCGGAAAAAGCTGGTATCCAAGCGGTCCCTACGGCCCGACCCCAACTTCGACGCCC
TGATCTCCAAAATCTATCCTAGCCGGGAGGAGTACGAGGCCCATCAAGACCGGGTGCTCATCCG
CCTCAGCCGCCTGCACAACCAGCAGGCGCTGAGCTCCAGTATCGAGGAGGGGCTTCGGATGCAG
GCCATGCACAGGGCCCAGCGTGTGAGGCGGCCGATGCCAGGATCTGATCAGACCACCACAATGA
GTGGGGGGGAAGGAGAGCCTGGGGAGGGAGAAGGGGATGGGGAGGACATAAGCTCCGACTCCGC
CCCAGACTCTGCTCCGGGCCCCGCTCCCAAGCGACCCCGTGGAGGGGGTGCAGGGGGCAGCAGT
GTAGGGACAGGGGGTGGTGCTGCTGGTGGGGCTTGCGGGGGTGCTGGTTCTGAAGACTCTGGTG
ATCGGGGCGGCACCCTGGGAGGGGGAACCCTAGGCCCCCCAAGCCCTCCTGGGGCTCCCAGTCC
TCCAGAGCCAGGTGGAGAGATCGAGCTTGTGTTCCGGCCCCATCCCCTGCTTGTGGAGAAAGGA
GAATACTGCCAGACTAGGTATGTGAAGACTACTGGGAATGCCACAGTGGATCACCTCTCCAAGT
ACTTGGCCCTGCGCATTGCCCTGGAGAGGAGGCAGCAGCAGGAAACCGTAGAGCCCGGAGGGCC
TGGCGGGGGTGCCTCGGACACAGGCGGACCTGACGGGGGTGGTGGGGAGAGAGGGGTTTCTGGA
GGAGGCGAAGGTCCTGAGGAGCCTGCCCTGCCCAGCCTGGAAGGTGTCAGCGAAAAACAGTACA
CCATCTACATAGCTCCTGGGGGCGGAGCATTCACGACGCTGAATGGCTCCCTGACCTTGGAGCT
TGTGAACGAGAAGTTCTGGAAGGTCTCCAGGCCGTTAGAGCTATGCTATGCCCCGACGAAGGAC
CCAAAATGACGTCACAGGGACAGCCAGAAGATGGGGACCATGGGGTGTCTCTGTGTCCCAGCTC
AGCCTGACAGCTTCATCTCCCAAAGCCCCCCAGCCAGACAGCAAGAGGACAGACAAGGGCAGAC
GGCTTTTATACAAAGTATCTATATTGAACTAGTCTATATTGTACAGCACGGGACCCGCGCCCAC
TACTGCCTTTTCTATGGGCCCCCACTGCCCACCGAGCCGGTGACCCGGCGGTCGAACAAGGCCC
CCTCCCCGCCCTCCTCCCAACAACAAATTTGCTTATTTCTTCTTTGAAAAAAAAAAAAAAAAAA
AAAAAAAAAAAAA

hide sequence

Protein Sequences


Protein RefSeqs	NP_997714	(Get FASTA)	NCBI Sequence Viewer
GenBank Protein	AAH98635	(Get FASTA)	NCBI Sequence Viewer
	BAK40272	(Get FASTA)	NCBI Sequence Viewer
	CAA64746	(Get FASTA)	NCBI Sequence Viewer
	CAE83930	(Get FASTA)	NCBI Sequence Viewer
	EDL96832	(Get FASTA)	NCBI Sequence Viewer
	Q6MGB6	(Get FASTA)	NCBI Sequence Viewer

Reference Sequences

RefSeq Acc Id:

NP_997714 ⟸ NM_212549

- UniProtKB:

Q63510 (UniProtKB/Swiss-Prot), Q6MGB6 (UniProtKB/Swiss-Prot)

- Sequence:

show sequence

MTTPANAQNASKTWELSLYELHRTPQEAIMDGTEIAVSPRSLHSELMCPICLDMLKNTMTTKEC
LHRFCSDCIVTALRSGNKECPTCRKKLVSKRSLRPDPNFDALISKIYPSREEYEAHQDRVLIRL
SRLHNQQALSSSIEEGLRMQAMHRAQRVRRPMPGSDQTTTMSGGEGEPGEGEGDGEDISSDSAP
DSAPGPAPKRPRGGGAGGSSVGTGGGAAGGACGGAGSEDSGDRGGTLGGGTLGPPSPPGAPSPP
EPGGEIELVFRPHPLLVEKGEYCQTRYVKTTGNATVDHLSKYLALRIALERRQQQETVEPGGPG
GGASDTGGPDGGGGERGVSGGGEGPEEPALPSLEGVSEKQYTIYIAPGGGAFTTLNGSLTLELV
NEKFWKVSRPLELCYAPTKDPK

hide sequence

RefSeq Acc Id:

ENSRNOP00000000543 ⟸ ENSRNOT00000000543

RefSeq Acc Id:

ENSRNOP00000073573 ⟸ ENSRNOT00000081085

Protein Domains

RING-type

Protein Structures

Name	Modeler	Protein Id	AA Range	Protein Structure
AF-Q6MGB6-F1-model_v2	AlphaFold	Q6MGB6	1-406	view protein structure

Transcriptome

eQTL		View at Phenogen
WGCNA		View at Phenogen
Tissue/Strain Expression		View at Phenogen

Promoters

RGD ID:

13701314

Promoter ID:

EPDNEW_R11838

Type:

multiple initiation site

Name:

Ring1_1

Description:

ring finger protein 1

SO ACC ID:

SO:0000170

Source:

EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)

Experiment Methods:

Single-end sequencing.

Position:

Rat Assembly	Chr	Position (strand)	Source
Rnor_6.0	20	3,815,833 - 3,815,893	EPDNEW

Additional Information

External Database Links

Database	Acc Id	Source(s)
AGR Gene	RGD:3576	AgrOrtholog
BioCyc Gene	G2FUF-4537	BioCyc
Ensembl Genes	ENSRNOG00000000467	Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Protein	ENSRNOP00000000543	ENTREZGENE
	ENSRNOP00000000543.4	UniProtKB/TrEMBL
	ENSRNOP00000073573.2	UniProtKB/TrEMBL
Ensembl Transcript	ENSRNOT00000000543	ENTREZGENE
	ENSRNOT00000000543.5	UniProtKB/TrEMBL
	ENSRNOT00000081085.2	UniProtKB/TrEMBL
Gene3D-CATH	3.30.40.10	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
IMAGE_CLONE	IMAGE:7098264	IMAGE-MGC_LOAD
InterPro	RAWUL	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	RING1/RING2	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	RING1_RING-HC	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	Znf_RING	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	Znf_RING/FYVE/PHD	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	Znf_RING_CS	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report	rno:309626	UniProtKB/Swiss-Prot
MGC_CLONE	MGC:112563	IMAGE-MGC_LOAD
NCBI Gene	309626	ENTREZGENE
PANTHER	E3 UBIQUITIN-PROTEIN LIGASE RING1	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	PTHR46076	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam	RAWUL	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	zf-C3HC4_2	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen	Ring1	PhenoGen
PROSITE	ZF_RING_1	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	ZF_RING_2	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
SMART	RING	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP	RING/U-box	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt	A0A0G2K5V5_RAT	UniProtKB/TrEMBL
	A0A8L2Q066_RAT	UniProtKB/TrEMBL
	F7IXA2_RAT	UniProtKB/TrEMBL
	Q63510	ENTREZGENE
	Q6MGB6	ENTREZGENE, UniProtKB/Swiss-Prot
UniProt Secondary	Q4KMC1	UniProtKB/Swiss-Prot
	Q63510	UniProtKB/Swiss-Prot

Nomenclature History

Date	Current Symbol	Current Name	Previous Symbol	Previous Name	Description	Reference	Status
2002-06-10	Ring1	RING finger protein 1			Symbol and Name status set to approved	70586	APPROVED

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

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