Ren (renin) - Rat Genome Database

Send us a Message



Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   
Gene: Ren (renin) Rattus norvegicus
Analyze
Symbol: Ren
Name: renin
RGD ID: 3554
Description: Exhibits endopeptidase activity and insulin-like growth factor receptor binding activity. Involved in several processes, including peptide metabolic process; response to lipopolysaccharide; and response to purine-containing compound. Localizes to cytoplasm and extracellular space. Used to study hypertension. Biomarker of primary biliary cholangitis. Human ortholog(s) of this gene implicated in familial juvenile hyperuricemic nephropathy; hypertension; and portal hypertension. Orthologous to human REN (renin); PARTICIPATES IN renin-angiotensin cascade pathway; benazepril pharmacodynamics pathway; candesartan pharmacodynamics pathway; INTERACTS WITH 1-naphthyl isothiocyanate; 11-deoxycorticosterone; 2,3,7,8-tetrachlorodibenzodioxine.
Type: protein-coding
RefSeq Status: PROVISIONAL
Also known as: angiotensinogenase; RATRENAA; Ren1; RENAA; renin 1; renin 1 structural
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Allele / Splice: Renem1Mcwi  
Genetic Models: SS-Renem1Mcwi
Is Marker For: Strains:   SS.BN-(D13Rat20-D13Rat127)/Mcwi   SS.BN-(D13Hmgc64-RN34_13048990782)/Mcwi  
QTLs:   Bp24   Bp5  
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.21344,796,260 - 44,807,491 (+)NCBI
Rnor_6.0 Ensembl1350,502,724 - 50,514,151 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_6.01350,502,724 - 50,513,953 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.01355,555,583 - 55,566,812 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41346,262,936 - 46,275,213 (+)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.11346,277,000 - 46,288,249 (+)NCBI
Celera1345,129,122 - 45,139,889 (+)NCBICelera
RH 3.4 Map13170.9RGD
Cytogenetic Map13q13NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View
acute kidney failure  (ISO)
Albuminuria  (ISO)
Allanson Pantzar McLeod Syndrome  (ISO)
anemia  (ISO)
atrial fibrillation  (ISO)
autistic disorder  (ISO)
Autosomal Dominant Tubulointerstitial Kidney Disease 4  (ISO)
Azotemia  (ISO)
Bartter disease  (ISO)
Cardiomegaly  (ISO)
chronic fatigue syndrome  (ISO)
colitis  (ISO)
congenital adrenal hyperplasia  (ISO)
congestive heart failure  (ISO)
Critical Illness  (ISO)
Diabetic Nephropathies  (IDA)
Drug-Related Side Effects and Adverse Reactions  (ISO)
Endotoxemia  (IEP,ISO)
essential hypertension  (ISO)
Experimental Diabetes Mellitus  (ISO)
familial juvenile hyperuricemic nephropathy  (ISS)
Fetal Growth Retardation  (ISO)
Fibrosis  (ISO)
gastrointestinal stromal tumor  (ISO)
Hemorrhage  (ISO)
human cytomegalovirus infection  (ISO)
hypertension  (IDA,ISO)
Hyponatremia  (IEP)
Hypotension  (ISO)
ischemia  (ISO)
kidney disease  (ISO)
kidney failure  (ISO)
Left Ventricular Hypertrophy  (IEP,ISO)
Liddle syndrome  (ISO)
liver cirrhosis  (ISO)
malignant hypertension  (ISO)
mental depression  (ISO)
myocardial infarction  (ISO)
nephrosis  (ISO)
nephrotic syndrome  (ISO)
obesity  (ISO)
osteoporosis  (ISO)
parathyroid carcinoma  (ISO)
periodontal disease  (ISO)
portal hypertension  (ISO)
Preeclamptic Toxemia  (ISO)
primary biliary cholangitis  (IEP)
proteinuria  (ISO)
psoriasis  (ISO)
Puromycin Aminonucleoside Nephrosis  (IEP)
Renal Tubular Dysgenesis  (ISO)
renovascular hypertension  (ISO)
Retina Reperfusion Injury  (IMP)
toxic shock syndrome  (ISO)
withdrawal disorder  (ISO)

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(R)-adrenaline  (ISO)
1-(propan-2-ylamino)-3-(2-prop-2-enoxyphenoxy)-2-propanol  (ISO)
1-naphthyl isothiocyanate  (EXP)
11-deoxycorticosterone  (EXP)
17alpha-ethynylestradiol  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,4-dinitrotoluene  (EXP)
2,6-dinitrotoluene  (EXP)
2-hydroxypropanoic acid  (ISO)
3'-amino-3'-deoxy-N(6),N(6)-dimethyladenosine  (EXP)
3,3',5,5'-tetrabromobisphenol A  (EXP)
3-isobutyl-1-methyl-7H-xanthine  (ISO)
4-[1-hydroxy-2-(1-phenoxypropan-2-ylamino)propyl]phenol  (ISO)
6alpha-methylprednisolone  (EXP)
acebutolol  (EXP,ISO)
acetaldehyde  (EXP)
acetamide  (EXP)
acetylsalicylic acid  (ISO)
actinomycin D  (ISO)
adenosine  (EXP)
aflatoxin B1  (ISO)
albuterol  (ISO)
aldehydo-D-glucose  (EXP)
aldosterone  (ISO)
aliskiren  (EXP,ISO)
all-trans-retinoic acid  (ISO)
alpha-methyl-L-dopa  (EXP)
alprenolol  (ISO)
aluminium phosphide  (ISO)
amlodipine  (ISO)
ammonium chloride  (EXP)
atenolol  (EXP,ISO)
benazepril  (EXP,ISO)
bendroflumethiazide  (ISO)
benzo[a]pyrene  (ISO)
bis(2-ethylhexyl) phthalate  (EXP,ISO)
bisphenol A  (EXP,ISO)
bucladesine  (ISO)
bumetanide  (ISO)
bunitrolol  (ISO)
caffeine  (EXP,ISO)
calcitriol  (ISO)
calcium atom  (EXP)
calcium(0)  (EXP)
calyculin a  (EXP)
candesartan  (EXP,ISO)
carvedilol  (ISO)
celecoxib  (EXP)
CGS-21680  (EXP)
chlorisondamine  (EXP)
chlorthalidone  (ISO)
choline  (ISO)
cilazapril monohydrate  (EXP)
clofibrate  (ISO)
clonidine  (ISO)
clonidine (amino form)  (ISO)
clonidine (imino form)  (ISO)
colforsin daropate hydrochloride  (ISO)
cortisol  (ISO)
cyanamide  (EXP)
cycloheximide  (ISO)
cyclosporin A  (EXP,ISO)
D-glucose  (EXP)
desflurane  (ISO)
dexamethasone  (EXP,ISO)
diethylstilbestrol  (ISO)
dihydralazine  (ISO)
diltiazem  (ISO)
dobutamine  (ISO)
doxazosin  (ISO)
doxorubicin  (ISO)
EC 3.4.15.1 (peptidyl-dipeptidase A) inhibitor  (EXP,ISO)
enalapril  (EXP,ISO)
enalaprilat dihydrate  (EXP)
endralazine  (EXP)
esmolol  (ISO)
ethanol  (EXP)
fenoterol  (ISO)
fentanyl  (ISO)
folic acid  (ISO)
furosemide  (EXP,ISO)
genistein  (EXP)
gentamycin  (EXP)
glucose  (EXP)
glycidol  (EXP)
glycyrrhetinate  (ISO)
glycyrrhetinic acid  (ISO)
glycyrrhizinic acid  (ISO)
Guanfacine  (ISO)
halothane  (ISO)
hydralazine  (EXP,ISO)
hydrochlorothiazide  (EXP,ISO)
ICI 118551  (ISO)
indapamide  (ISO)
indometacin  (EXP,ISO)
indoxyl sulfate  (EXP)
iooxitalamic acid  (EXP)
irbesartan  (ISO)
isoflurane  (ISO)
isoprenaline  (EXP,ISO)
Isradipine  (ISO)
ketamine  (ISO)
ketoconazole  (ISO)
ketoprofen  (ISO)
L-methionine  (ISO)
labetalol  (ISO)
lipopolysaccharide  (ISO)
lisinopril dihydrate  (EXP,ISO)
losartan  (EXP,ISO)
magnesium sulfate  (ISO)
meclofenamic acid  (EXP)
methoxychlor  (EXP)
methylmercury chloride  (ISO)
metoprolol  (EXP,ISO)
milrinone  (ISO)
minoxidil  (EXP,ISO)
ML-7  (EXP)
N-acetyl-L-cysteine  (EXP)
N-nitrosomorpholine  (EXP)
N1'-[2-[[5-[(dimethylamino)methyl]-2-furanyl]methylthio]ethyl]-N1-methyl-2-nitroethene-1,1-diamine  (ISO)
naloxone  (ISO)
naproxen  (ISO)
nebivolol  (EXP)
Nicardipine  (ISO)
nifedipine  (ISO)
Nilvadipine  (EXP)
nitrendipine  (ISO)
nitric oxide  (EXP)
nitrofen  (EXP)
nitroglycerin  (ISO)
nitroprusside  (EXP,ISO)
O-methyleugenol  (ISO)
paracetamol  (ISO)
paricalcitol  (ISO)
pentobarbital  (EXP)
perindopril  (EXP,ISO)
phentolamine  (ISO)
phenylephrine  (ISO)
phosphorus atom  (ISO)
phosphorus(.)  (ISO)
pindolol  (ISO)
piperidines  (ISO)
pirinixic acid  (ISO)
potassium bromate  (EXP)
practolol  (EXP)
prazosin  (EXP,ISO)
probenecid  (ISO)
propofol  (ISO)
propranolol  (EXP,ISO)
prostaglandin E1  (ISO)
prostaglandin E2  (ISO)
quercetin  (EXP)
quinapril hydrochloride  (EXP)
rac-lactic acid  (ISO)
ramipril  (EXP,ISO)
ranitidine  (ISO)
reboxetine  (ISO)
riddelliine  (EXP)
ritodrine  (ISO)
sildenafil citrate  (ISO)
silver atom  (EXP)
silver(0)  (EXP)
sirolimus  (EXP)
sodium atom  (EXP,ISO)
sodium chloride  (EXP,ISO)
soyasaponin I  (ISO)
Soyasaponin II  (ISO)
spirapril  (EXP)
spironolactone  (ISO)
sulindac  (ISO)
tacrolimus hydrate  (EXP)
telmisartan  (EXP)
terbutaline  (ISO)
Testosterone propionate  (EXP)
tetrachloromethane  (EXP)
theophylline  (ISO)
tienilic acid  (ISO)
titanium dioxide  (EXP)
torasemide  (EXP)
trandolapril  (EXP,ISO)
trichloroethene  (EXP)
valproic acid  (ISO)
valsartan  (EXP,ISO)
yohimbine  (EXP)

Phenotype Annotations     Click to see Annotation Detail View

Mammalian Phenotype
References

References - curated
1. Ahmad U, etal., Hypertens Res. 2005 Apr;28(4):339-44.
2. Alderman MH, etal., N Engl J Med. 1991 Apr 18;324(16):1098-104.
3. Annat G, etal., Obstet Gynecol. 1978 Aug;52(2):219-24.
4. Azibani F, etal., Ann Cardiol Angeiol (Paris). 2012 May 25.
5. Baggio B, etal., Ital J Biochem. 1975 May-Aug;24(3-4):199-206.
6. Burnham CE, etal., Proc Natl Acad Sci U S A 1987 Aug;84(16):5605-9.
7. Chao J, etal., Am J Physiol Heart Circ Physiol. 2011 Dec;301(6):H2264-70. Epub 2011 Sep 30.
8. Chen JG, etal., Surg Endosc. 2012 May 31.
9. Chen SD, etal., Neurochem Int. 2012 May 17;61(3):369-377.
10. Chung KS, etal., Korean J Crit Care Med. 2017 May;32(2):142-153. doi: 10.4266/kjccm.2017.00094. Epub 2017 May 31.
11. Clausmeyer S, etal., Circ Res 1999 Feb 19;84(3):337-44.
12. De Vos AC, etal., Physiol Behav. 2018 Oct 1;194:474-480. doi: 10.1016/j.physbeh.2018.06.038. Epub 2018 Jun 28.
13. Dubay C, etal., Nat Genet 1993 Apr;3(4):354-7
14. Feng Q, etal., Biosci Rep. 2018 Jun 27;38(3). pii: BSR20171522. doi: 10.1042/BSR20171522. Print 2018 Jun 29.
15. Fukamizu A, etal., J Mol Biol 1988 May 20;201(2):443-50.
16. Gambaryan S, etal., Proc Natl Acad Sci U S A. 1998 Jul 21;95(15):9003-8.
17. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
18. Gleeson PJ, etal., Crit Care Med. 2019 Feb;47(2):152-158. doi: 10.1097/CCM.0000000000003544.
19. GOA data from the GO Consortium
20. Gonzalez AA, etal., Hypertension. 2011 Apr;57(4):859-64. Epub 2011 Feb 14.
21. Gribouval O, etal., Nat Genet. 2005 Sep;37(9):964-8. Epub 2005 Aug 14.
22. Guagliardo NA, etal., Hypertension. 2012 May;59(5):999-1005. Epub 2012 Apr 9.
23. Hao XQ, etal., Exp Toxicol Pathol. 2012 Feb 17.
24. Harris EL, etal., J Hypertens 1995 Apr;13(4):397-404.
25. Hoffman MJ, etal., Hypertension. 2013 Sep;62(3):557-63. doi: 10.1161/HYPERTENSIONAHA.113.01708. Epub 2013 Jul 1.
26. Ichihara A, etal., J Clin Invest. 2004 Oct;114(8):1128-35.
27. Jindra A Jr and Kvetnansky R, J Biol Chem. 1982 Jun 10;257(11):5997-9.
28. Kammerl MC, etal., Am J Physiol Regul Integr Comp Physiol 2002 Jun;282(6):R1613-7.
29. Kwitek AE, etal., Genome Res. 2004 Apr;14(4):750-7
30. Leckie BJ Curr Med Chem Cardiovasc Hematol Agents. 2005 Jan;3(1):23-32.
31. Li JL, etal., Zhongguo Wei Zhong Bing Ji Jiu Yi Xue. 2006 Feb;18(2):92-5.
32. Li Y, etal., Int J Cardiol. 2011 Sep 10.
33. Margatho LO, etal., Neuroscience. 2015 Jun 25;297:78-88. doi: 10.1016/j.neuroscience.2015.03.059. Epub 2015 Apr 1.
34. Meurer M, etal., Pflugers Arch. 2018 Nov;470(11):1691-1703. doi: 10.1007/s00424-018-2183-3. Epub 2018 Jul 19.
35. MGD data from the GO Consortium
36. Morris BJ and Johnston CI, Endocrinology. 1976 Jun;98(6):1466-74.
37. NCBI rat LocusLink and RefSeq merged data July 26, 2002
38. Nguyen G, Kidney Int. 2006 May;69(9):1503-6.
39. Nguyen LS, etal., Eur J Endocrinol. 2019 Nov;181(5):481-488. doi: 10.1530/EJE-19-0379.
40. Nguyen M, etal., Shock. 2019 Oct;52(4):e22-e30. doi: 10.1097/SHK.0000000000001285.
41. Oka M, etal., Hypertension. 2017 Jul;70(1):119-128. doi: 10.1161/HYPERTENSIONAHA.117.09283. Epub 2017 May 22.
42. Okamoto LE, etal., Clin Sci (Lond). 2012 Feb;122(4):183-92. doi: 10.1042/CS20110200.
43. Oliveira SHP, etal., Front Pharmacol. 2019 Jul 4;10:708. doi: 10.3389/fphar.2019.00708. eCollection 2019.
44. OMIM Disease Annotation Pipeline
45. Paliege A, etal., Am J Physiol Regul Integr Comp Physiol. 2006 Mar;290(3):R694-700.
46. Patel RB, etal., Eur J Pharmacol. 2014 Aug 15;737:70-6. doi: 10.1016/j.ejphar.2014.05.009. Epub 2014 May 21.
47. Pipeline to import KEGG annotations from KEGG into RGD
48. Pipeline to import SMPDB annotations from SMPDB into RGD
49. RGD automated data pipeline
50. RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
51. RGD automated import pipeline for gene-chemical interactions
52. Richer C, etal., Clin Exp Pharmacol Physiol 2001 Dec;28(12):997-1001.
53. Saris JJ, etal., Am J Physiol Heart Circ Physiol. 2001 Apr;280(4):H1706-15.
54. Shah N, etal., J Hepatol. 2012 May;56(5):1047-53. Epub 2012 Jan 17.
55. Shionoiri H, etal., Am J Med Sci. 1990 Sep;300(3):138-43. doi: 10.1097/00000441-199009000-00002.
56. St Lezin EM, etal., J Clin Invest. 1996 Jan 15;97(2):522-7.
57. St. Lezin EM, etal., J Clin Invest 1996 Jan 15;97(2):522-7
58. Tada M, etal., Nucleic Acids Res 1988 Apr 25;16(8):3576.
59. Takatsu M, etal., J Hypertens. 2012 Jul 12.
60. Tenkumo K, etal., Exp Eye Res. 2014 May;122:110-8. doi: 10.1016/j.exer.2014.03.011. Epub 2014 Apr 5.
61. Tronik D, etal., Gene 1988 Sep 15;69(1):71-80.
62. Voigt J, etal., Eur J Biochem. 1982 Feb;122(1):183-91.
63. Warner GM, etal., Am J Physiol Renal Physiol. 2012 Jun;302(11):F1455-64. Epub 2012 Feb 29.
64. Wilkinson-Berka JL, etal., Mol Cell Endocrinol. 2002 Aug 30;194(1-2):201-9.
65. Xiang W, etal., Am J Physiol Endocrinol Metab. 2005 Jan;288(1):E125-32. Epub 2004 Sep 14.
66. Yamamoto Y, Jpn Heart J. 1975 Jul;16(4):404-20. doi: 10.1536/ihj.16.404.
67. Yayama K, etal., Nephron. 1993;63(1):89-93.
68. Yeung RS, etal., Mamm Genome 1993;4(10):585-8.
69. Zhang L, etal., World J Gastroenterol. 2003 Jul;9(7):1584-8.
Additional References at PubMed
PMID:4289389   PMID:4322712   PMID:4330891   PMID:4360430   PMID:8490598   PMID:9933256   PMID:10318840   PMID:10617578   PMID:10807585   PMID:11145610   PMID:11702851   PMID:12045255  
PMID:12469222   PMID:12477932   PMID:12511427   PMID:12560203   PMID:14583438   PMID:15342908   PMID:15489334   PMID:15792957   PMID:15870381   PMID:17440033   PMID:17670863   PMID:18198281  
PMID:18202178   PMID:18413493   PMID:18426992   PMID:18509102   PMID:18653711   PMID:18671756   PMID:18782187   PMID:19050177   PMID:19139376   PMID:19171793   PMID:19261739   PMID:19293336  
PMID:19841286   PMID:19861503   PMID:20683339   PMID:20852041   PMID:21242461   PMID:21331057   PMID:21483231   PMID:21484732   PMID:21521778   PMID:21752621   PMID:21865264   PMID:22020141  
PMID:23460292   PMID:24119481   PMID:24204720   PMID:24436324   PMID:24473199   PMID:25394830   PMID:25707593   PMID:25766467   PMID:25767135   PMID:26256830   PMID:26322847   PMID:26660905  
PMID:27090360   PMID:27443990   PMID:27545826   PMID:28161727   PMID:28715805   PMID:29521603   PMID:30110572   PMID:30247805  


Genomics

Candidate Gene Status
Ren is a candidate Gene for QTL Bp80
Ren is a candidate Gene for QTL Bp328
Ren is a candidate Gene for QTL Bp395
Comparative Map Data
Ren
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.21344,796,260 - 44,807,491 (+)NCBI
Rnor_6.0 Ensembl1350,502,724 - 50,514,151 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_6.01350,502,724 - 50,513,953 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.01355,555,583 - 55,566,812 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41346,262,936 - 46,275,213 (+)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.11346,277,000 - 46,288,249 (+)NCBI
Celera1345,129,122 - 45,139,889 (+)NCBICelera
RH 3.4 Map13170.9RGD
Cytogenetic Map13q13NCBI
REN
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl1204,154,819 - 204,190,324 (-)EnsemblGRCh38hg38GRCh38
GRCh381204,154,819 - 204,166,337 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh371204,123,947 - 204,135,465 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361202,390,571 - 202,402,088 (-)NCBINCBI36hg18NCBI36
Build 341200,855,604 - 200,867,122NCBI
Celera1177,259,194 - 177,270,715 (-)NCBI
Cytogenetic Map1q32.1NCBI
HuRef1175,289,120 - 175,300,481 (-)NCBIHuRef
CHM1_11205,547,624 - 205,559,145 (-)NCBICHM1_1
Ren1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391133,278,412 - 133,288,058 (+)NCBIGRCm39mm39
GRCm39 Ensembl1133,278,248 - 133,288,063 (+)Ensembl
GRCm381133,350,674 - 133,360,320 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1133,350,510 - 133,360,325 (+)EnsemblGRCm38mm10GRCm38
MGSCv371135,247,251 - 135,256,894 (+)NCBIGRCm37mm9NCBIm37
MGSCv361135,178,238 - 135,187,863 (+)NCBImm8
Celera1135,963,151 - 135,972,794 (+)NCBICelera
Cytogenetic Map1E4NCBI
cM Map157.91NCBI
Ren
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495540640,016,630 - 40,026,286 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495540640,016,624 - 40,026,286 (-)NCBIChiLan1.0ChiLan1.0
REN
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.11184,045,917 - 184,057,431 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1184,046,117 - 184,057,393 (-)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v01179,757,653 - 179,769,530 (-)NCBIMhudiblu_PPA_v0panPan3
REN
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.138744,540 - 766,998 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl38744,614 - 755,012 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha38840,126 - 850,501 (-)NCBI
ROS_Cfam_1.038740,693 - 762,325 (-)NCBI
UMICH_Zoey_3.138736,523 - 746,891 (-)NCBI
UNSW_CanFamBas_1.0381,127,902 - 1,138,260 (-)NCBI
UU_Cfam_GSD_1.0381,328,102 - 1,338,487 (-)NCBI
Ren
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440934471,363,409 - 71,373,041 (+)NCBI
SpeTri2.0NW_004936567598,044 - 607,628 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
REN
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl964,809,146 - 64,822,636 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1964,809,143 - 64,822,605 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2971,147,542 - 71,151,808 (-)NCBISscrofa10.2Sscrofa10.2susScr3
REN
(Chlorocebus sabaeus - African green monkey)
Vervet AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12525,159,816 - 25,193,620 (+)NCBI
ChlSab1.1 Ensembl2525,183,037 - 25,193,420 (+)Ensembl
Ren
(Heterocephalus glaber - naked mole-rat)
Molerat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_0046248076,817,472 - 6,827,374 (+)NCBI

Position Markers
D13Uwm1  
Rat AssemblyChrPosition (strand)SourceJBrowse
RGSC_v3.11346,283,977 - 46,284,161RGD
RH 3.4 Map13173.5UniSTS
Cytogenetic Map13q13UniSTS
D13Wox5  
Rat AssemblyChrPosition (strand)SourceJBrowse
Rnor_5.01355,560,677 - 55,560,862NCBIRnor5.0
RGSC_v3.41346,269,934 - 46,270,118RGDRGSC3.4
RGSC_v3.11346,283,977 - 46,284,161RGD
RH 3.4 Map13173.5RGD
RH 3.4 Map13173.5UniSTS
RH 2.0 Map13376.9RGD
Cytogenetic Map13q13UniSTS
D13Arb7  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21344,802,093 - 44,802,410 (-)MAPPER
Rnor_6.01350,507,805 - 50,508,121NCBIRnor6.0
Rnor_5.01355,560,664 - 55,560,980UniSTSRnor5.0
RGSC_v3.41346,269,815 - 46,270,132RGDRGSC3.4
RGSC_v3.41346,269,816 - 46,270,132UniSTSRGSC3.4
RGSC_v3.11346,283,858 - 46,284,175RGD
Celera1345,134,496 - 45,134,808UniSTS
RH 3.4 Map13182.9UniSTS
RH 3.4 Map13182.9RGD
SHRSP x BN Map1314.7498UniSTS
SHRSP x BN Map1314.7498RGD
Cytogenetic Map13q13UniSTS
RH94507  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21344,795,892 - 44,796,082 (-)MAPPER
Rnor_6.01350,514,131 - 50,514,320NCBIRnor6.0
Rnor_5.01355,566,990 - 55,567,179UniSTSRnor5.0
RGSC_v3.41346,262,569 - 46,262,758UniSTSRGSC3.4
Celera1345,128,755 - 45,128,944UniSTS
RH 3.4 Map13170.9UniSTS
Cytogenetic Map13q13UniSTS
RH138392  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21344,807,241 - 44,807,417 (-)MAPPER
Rnor_6.01350,502,798 - 50,502,973NCBIRnor6.0
Rnor_5.01355,555,657 - 55,555,832UniSTSRnor5.0
RGSC_v3.41346,274,964 - 46,275,139UniSTSRGSC3.4
Celera1345,139,640 - 45,139,815UniSTS
RH 3.4 Map13181.6UniSTS
Cytogenetic Map13q13UniSTS


QTLs in Region (Rnor_6.0)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1354666Bp244Blood pressure QTL 2444.9arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)131107975663Rat
1354666Bp244Blood pressure QTL 2444.9arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)131107975663Rat
1354666Bp244Blood pressure QTL 2444.9arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)131107975663Rat
61339Bp24Blood pressure QTL 240.05arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)13901674250513953Rat
1581554Pur11Proteinuria QTL 11urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)13901690682995569Rat
1581573Uae36Urinary albumin excretion QTL 36urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)13901690682995569Rat
1581570Eae17Experimental allergic encephalomyelitis QTL 174.1nervous system integrity trait (VT:0010566)experimental autoimmune encephalomyelitis incidence/prevalence measurement (CMO:0001046)1312193394108478121Rat
9589141Insul28Insulin level QTL 2810.820.001blood insulin amount (VT:0001560)plasma insulin level (CMO:0000342)131409633059096330Rat
7411662Foco29Food consumption QTL 2920.80.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)131409633059096330Rat
1300163Cardf1Cardiac cell morphology QTL 14.18aorta morphology trait (VT:0000272)artery lesion measurement (CMO:0000975)131444158250799665Rat
2302275Gluco37Glucose level QTL 373.8blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)131444158251577031Rat
2317040Aia21Adjuvant induced arthritis QTL 212.75joint integrity trait (VT:0010548)left rear ankle joint diameter (CMO:0002149)131462463159624631Rat
2317046Aia8Adjuvant induced arthritis QTL 83.9700000286102295joint integrity trait (VT:0010548)left rear ankle joint diameter (CMO:0002149)131462463159624631Rat
631645Bp121Blood pressure QTL 1213.3arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)131981081464810814Rat
9589164Gluco66Glucose level QTL 666.670.001blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)132005247765052477Rat
1331784Bp222Blood pressure QTL 2222.944arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)132148248158537177Rat
7207885Glom27Glomerulus QTL 273.9kidney glomerulus integrity trait (VT:0010546)kidney crescentic glomeruli count to kidney normal glomeruli count ratio (CMO:0002139)1324502279108770533Rat
61391Bp5Blood pressure QTL 55.6arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)132800833873008338Rat
70170Eae14Experimental allergic encephalomyelitis QTL 140.0024nervous system integrity trait (VT:0010566)experimental autoimmune encephalomyelitis incidence/prevalence measurement (CMO:0001046)132858445273584452Rat
1558644Cm45Cardiac mass QTL 453.60.002heart mass (VT:0007028)heart wet weight (CMO:0000069)132907693474076934Rat
6893338Cm76Cardiac mass QTL 7600.99heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)132907693474076934Rat
1354621Rf47Renal function QTL 473.7kidney renin amount (VT:0010559)kidney renin level (CMO:0002166)1335301263107975663Rat
2301962Cm72Cardiac mass QTL 724.12heart left ventricle mass (VT:0007031)heart left ventricle weight (CMO:0000776)133614753364868393Rat
70181BpQTLcluster11Blood pressure QTL cluster 116.922arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)133614753399968921Rat
70181BpQTLcluster11Blood pressure QTL cluster 116.922arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)133614753399968921Rat
70181BpQTLcluster11Blood pressure QTL cluster 116.922arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)133614753399968921Rat
70181BpQTLcluster11Blood pressure QTL cluster 116.922arterial blood pressure trait (VT:2000000)absolute change in mean arterial blood pressure (CMO:0000533)133614753399968921Rat
2303563Bw89Body weight QTL 896body mass (VT:0001259)body weight (CMO:0000012)133734634882346348Rat
61340Bp25Blood pressure QTL 254.20.004arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)133937292784372927Rat
10755495Bp387Blood pressure QTL 3873.78arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)133950130093652524Rat
4889861Pur29Proteinuria QTL 2913.80.005total urine protein amount (VT:0000032)urine total protein excretion rate (CMO:0000756)134231074486833540Rat
1331750Bp220Blood pressure QTL 2202.98arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)134231074487310744Rat
70220Bp55Blood pressure QTL 555.75arterial blood pressure trait (VT:2000000)blood pressure measurement (CMO:0000003)134250834587508345Rat
61349Bp31Blood pressure QTL 315.75arterial blood pressure trait (VT:2000000)blood pressure measurement (CMO:0000003)134250834587508345Rat
1549897Stresp12Stress response QTL 123.35stress-related behavior trait (VT:0010451)number of approaches toward negative stimulus before onset of defensive burying response (CMO:0001960)134357571788575717Rat
619615Bp80Blood pressure QTL 800.0354arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)134567662990676629Rat
2303032Bp328Blood pressure QTL 328arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)134644457050799665Rat
4145117Mcs27Mammary carcinoma susceptibility QTL 270.0001mammary gland integrity trait (VT:0010552)post-insult time to mammary tumor formation (CMO:0000345)134877665553264877Rat
6893344Cm79Cardiac mass QTL 791.50.04heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)134905850767207219Rat
12879436Bp395Blood pressure QTL 395arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)134999470851081193Rat
12879444Bp397Blood pressure QTL 397arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)135026035750897964Rat


Related Rat Strains
The following Strains have been annotated to Ren


Genetic Models
This gene Ren is modified in the following models/strains
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:48
Count of miRNA genes:45
Interacting mature miRNAs:47
Transcripts:ENSRNOT00000003951
Prediction methods:Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 28 7
Low 23 19 19 19 7 23
Below cutoff 2 4 34 22 9 22 1 1 36 11 6 1

Sequence


Reference Sequences
RefSeq Acc Id: ENSRNOT00000003951   ⟹   ENSRNOP00000003951
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl1350,502,724 - 50,514,151 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000076747   ⟹   ENSRNOP00000067953
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl1350,509,024 - 50,509,916 (-)Ensembl
RefSeq Acc Id: NM_012642   ⟹   NP_036774
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21344,796,260 - 44,807,491 (+)NCBI
Rnor_6.01350,502,724 - 50,513,953 (-)NCBI
Rnor_5.01355,555,583 - 55,566,812 (-)NCBI
RGSC_v3.41346,262,936 - 46,275,213 (+)RGD
Celera1345,129,122 - 45,139,889 (+)RGD
Sequence:
Reference Sequences
RefSeq Acc Id: NP_036774   ⟸   NM_012642
- Peptide Label: precursor
- UniProtKB: P08424 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: ENSRNOP00000003951   ⟸   ENSRNOT00000003951
RefSeq Acc Id: ENSRNOP00000067953   ⟸   ENSRNOT00000076747
Protein Domains
Peptidase A1

Protein Structures
Name Modeller Protein Id AA Range Protein Structure Video
Prorenin pdb 4amt P08424 27-402 view protein structure view video
Renin1 pdb 2x0b P08424 65-402 view protein structure view video

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Strain Variation

Strain Sequence Variants (Rnor 6.0)
ACI/EurMcwi (MCW)
Visual CSV TAB Printer
Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
ACI/EurMcwi (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
ACI/N (MCW)
Visual CSV TAB Printer
Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
BBDP/Wor (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
BN/SsN (MCW)
Visual CSV TAB Printer
Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
Buf/N (MCW)
Visual CSV TAB Printer
Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
COP/CrCrl (MCW & UW)
Visual CSV TAB Printer
Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
University of Wisconsin (Dr. James Shull)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Charles River Laboratories
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob) and UW Madison (Dr. James Shull)
F344/NCrl (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
F344/NRrrc (MCW)
Visual CSV TAB Printer
Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
FHH/EurMcwi (MCW)
Visual CSV TAB Printer
Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
FHH/EurMcwi (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
FHL/EurMcwi (MCW)
Visual CSV TAB Printer
Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
FHL/EurMcwi (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
GH/OmrMcwi (MCW)
Visual CSV TAB Printer
Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
GK/Ox (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LE/Stm (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LEW/Crl (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LEW/NCrlBR (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LH/MavRrrc (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LL/MavRrrc (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LN/MavRrrc (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
M520/N (MCW)
Visual CSV TAB Printer
Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
MHS/Gib (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
MNS/Gib (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
MR/N (MCW)
Visual CSV TAB Printer
Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
SBH/Ygl (MCW)
Visual CSV TAB Printer
Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: SBH/Ygl sequenced by MCW
SBH/Ygl (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SBN/Ygl (MCW)
Visual CSV TAB Printer
Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: SBN/Ygl sequenced by MCW
SBN/Ygl (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SHR/NHsd (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SHRSP/Gcrc (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SR/JrHsd (MCW)
Visual CSV TAB Printer
Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Harlan Laboratories
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
SR/JrHsd (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SS/Jr (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SS/JrHsdMcwi (MCW)
Visual CSV TAB Printer
Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
SS/JrHsdMcwi (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WAG/Rij (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WKY/Gcrc (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WKY/N (MCW)
Visual CSV TAB Printer
Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
WKY/NCrl (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WKY/NHsd (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WN/N (MCW)
Visual CSV TAB Printer
Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:3554 AgrOrtholog
Ensembl Genes ENSRNOG00000002937 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Ensembl Protein ENSRNOP00000003951 ENTREZGENE, UniProtKB/Swiss-Prot
  ENSRNOP00000067953 UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000003951 ENTREZGENE, UniProtKB/Swiss-Prot
  ENSRNOT00000076747 UniProtKB/TrEMBL
Gene3D-CATH 2.40.70.10 UniProtKB/Swiss-Prot
IMAGE_CLONE IMAGE:7126969 IMAGE-MGC_LOAD
InterPro Aspartic_peptidase_A1 UniProtKB/Swiss-Prot
  Aspartic_peptidase_AS UniProtKB/Swiss-Prot
  PEPTIDASE_A1 UniProtKB/Swiss-Prot
  Peptidase_aspartic_dom_sf UniProtKB/Swiss-Prot
  Renin-like_dom UniProtKB/Swiss-Prot
KEGG Report rno:24715 UniProtKB/Swiss-Prot
MGC_CLONE MGC:93560 IMAGE-MGC_LOAD
NCBI Gene 24715 ENTREZGENE
PANTHER PTHR47966 UniProtKB/Swiss-Prot
Pfam Asp UniProtKB/Swiss-Prot
PharmGKB REN RGD
PhenoGen Ren PhenoGen
PRINTS PEPSIN UniProtKB/Swiss-Prot
PROSITE ASP_PROTEASE UniProtKB/Swiss-Prot
  PEPTIDASE_A1 UniProtKB/Swiss-Prot
Superfamily-SCOP SSF50630 UniProtKB/Swiss-Prot
UniProt P08424 ENTREZGENE
  Q9JIE2_RAT UniProtKB/TrEMBL
  RENI_RAT UniProtKB/Swiss-Prot
UniProt Secondary Q63497 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2008-09-24 Ren  renin  Ren1  renin 1 structural  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-05-15 Ren1  renin 1 structural  Ren1  renin 1  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2003-04-09 Ren1  renin 1  Ren  Renin  Symbol and Name updated 629477 APPROVED
2002-06-10 Ren  Renin      Symbol and Name status set to approved 70586 APPROVED

RGD Curation Notes
Note Type Note Reference
gene_disease affects heart mass independent of blood pressure 1357231
gene_expression expressed in the juxtaglomerular apparatus 625761
gene_regulation expression in the juxtaglomerular apparatus during low-salt diet is greatly reduced by a direct feedback inhibition through ANG II 625761