Gene-Chemical Interaction Annotations Click to see Annotation Detail View
Object Symbol | Species | Term | Qualifier | Evidence | With | Reference | Notes | Source | Original Reference(s) | AKR1B15 | Human | (1->4)-beta-D-glucan | multiple interactions | ISO | Akr1b7 (Mus musculus) | 6480464 | [perfluorooctane sulfonic acid co-treated with Cellulose] results in increased expression of AKR1B7 mRNA | CTD | PMID:36331819 | AKR1B15 | Human | 1,2-dimethylhydrazine | decreases expression | ISO | Akr1b7 (Mus musculus) | 6480464 | 1 and 2-Dimethylhydrazine results in decreased expression of AKR1B7 mRNA | CTD | PMID:22206623 | AKR1B15 | Human | 17alpha-ethynylestradiol | multiple interactions | ISO | Akr1b7 (Mus musculus) | 6480464 | [Ibuprofen co-treated with hydroxyibuprofen co-treated with Diclofenac co-treated with Ethinyl Estradiol] results in decreased expression of AKR1B7 mRNA | CTD | PMID:37844793 | AKR1B15 | Human | 2,2',4,4',5,5'-hexachlorobiphenyl | multiple interactions | ISO | Akr1b7 (Mus musculus) | 6480464 | [2 more ... | CTD | PMID:21851831 and PMID:25510870 | AKR1B15 | Human | 2,2',4,4',5,5'-hexachlorobiphenyl | increases expression | ISO | Akr1b7 (Mus musculus) | 6480464 | 2 more ... | CTD | PMID:20005886 and PMID:21851831 | AKR1B15 | Human | 2,2',5,5'-tetrachlorobiphenyl | multiple interactions | ISO | Akr1b7 (Mus musculus) | 6480464 | [2 more ... | CTD | PMID:25510870 | AKR1B15 | Human | 2,3,7,8-tetrachlorodibenzodioxine | multiple interactions | ISO | Akr1b7 (Mus musculus) | 6480464 | Tetrachlorodibenzodioxin inhibits the reaction [2 more ... | CTD | PMID:21851831 | AKR1B15 | Human | 2,3,7,8-tetrachlorodibenzodioxine | decreases expression | ISO | Akr1b7 (Mus musculus) | 6480464 | Tetrachlorodibenzodioxin results in decreased expression of AKR1B7 mRNA | CTD | PMID:19770486 | AKR1B15 | Human | 2,3,7,8-tetrachlorodibenzodioxine | affects expression | ISO | Akr1b7 (Mus musculus) | 6480464 | Tetrachlorodibenzodioxin affects the expression of AKR1B7 mRNA | CTD | PMID:21570461 | AKR1B15 | Human | 2-palmitoylglycerol | increases expression | EXP | | 6480464 | 2-palmitoylglycerol results in increased expression of AKR1B15 mRNA | CTD | PMID:37199045 | AKR1B15 | Human | 4-Hydroxybenzophenone | increases expression | ISO | Akr1b7 (Mus musculus) | 6480464 | 4-hydroxybenzophenone results in increased expression of AKR1B7 mRNA | CTD | PMID:35476924 | AKR1B15 | Human | 4-nitrobenzaldehyde | increases metabolic processing | EXP | | 6480464 | AKR1B15 protein results in increased metabolism of 4-nitrobenzaldehyde | CTD | PMID:21276782 | AKR1B15 | Human | 4-nitrophenol | increases expression | ISO | Akr1b7 (Mus musculus) | 6480464 | 4-nitrophenol results in increased expression of AKR1B7 mRNA | CTD | PMID:34673133 | AKR1B15 | Human | aflatoxin B1 | increases methylation | EXP | | 6480464 | Aflatoxin B1 results in increased methylation of AKR1B15 gene | CTD | PMID:27153756 | AKR1B15 | Human | aflatoxin B1 | decreases expression | ISO | Akr1b7 (Mus musculus) | 6480464 | Aflatoxin B1 results in decreased expression of AKR1B7 mRNA | CTD | PMID:19770486 | AKR1B15 | Human | all-trans-retinal | increases metabolic processing | ISO | Akr1b7 (Mus musculus) | 6480464 | AKR1B7 protein results in increased metabolism of Retinaldehyde | CTD | PMID:21329680 | AKR1B15 | Human | antimycin A | increases expression | ISO | Akr1b7 (Mus musculus) | 6480464 | Antimycin A results in increased expression of AKR1B7 mRNA | CTD | PMID:19304788 | AKR1B15 | Human | arsane | affects methylation | EXP | | 6480464 | Arsenic affects the methylation of AKR1B15 gene | CTD | PMID:25304211 | AKR1B15 | Human | arsenic atom | affects methylation | EXP | | 6480464 | Arsenic affects the methylation of AKR1B15 gene | CTD | PMID:25304211 | AKR1B15 | Human | benzo[a]pyrene | increases expression | EXP | | 6480464 | Benzo(a)pyrene results in increased expression of AKR1B15 mRNA | CTD | PMID:22316170 and PMID:32234424 | AKR1B15 | Human | benzo[a]pyrene | increases expression | ISO | Akr1b7 (Mus musculus) | 6480464 | Benzo(a)pyrene results in increased expression of AKR1B7 mRNA | CTD | PMID:32417428 | AKR1B15 | Human | benzo[a]pyrene | increases methylation | EXP | | 6480464 | Benzo(a)pyrene results in increased methylation of AKR1B15 exon and Benzo(a)pyrene results in increased methylation of AKR1B15 promoter | CTD | PMID:27901495 | AKR1B15 | Human | benzo[a]pyrene | decreases expression | ISO | Akr1b7 (Mus musculus) | 6480464 | Benzo(a)pyrene results in decreased expression of AKR1B7 mRNA | CTD | PMID:19770486 | AKR1B15 | Human | bis(2-ethylhexyl) phthalate | decreases expression | ISO | Akr1b7 (Mus musculus) | 6480464 | Diethylhexyl Phthalate results in decreased expression of AKR1B7 mRNA | CTD | PMID:27405655 | AKR1B15 | Human | bisphenol A | increases expression | ISO | Akr1b8 (Rattus norvegicus) | 6480464 | bisphenol A results in increased expression of AKR1B15 mRNA | CTD | PMID:25181051 | AKR1B15 | Human | cannabidiol | increases expression | ISO | Akr1b7 (Mus musculus) | 6480464 | Cannabidiol results in increased expression of AKR1B7 mRNA | CTD | PMID:21542829 | AKR1B15 | Human | carbon nanotube | decreases expression | ISO | Akr1b7 (Mus musculus) | 6480464 | Nanotubes more ... | CTD | PMID:25554681 and PMID:25620056 | AKR1B15 | Human | carbon nanotube | affects expression | ISO | Akr1b7 (Mus musculus) | 6480464 | Nanotubes and Carbon analog affects the expression of AKR1B7 mRNA | CTD | PMID:25620056 | AKR1B15 | Human | chlordecone | increases expression | ISO | Akr1b7 (Mus musculus) | 6480464 | Chlordecone results in increased expression of AKR1B7 mRNA | CTD | PMID:33711761 | AKR1B15 | Human | choline | multiple interactions | ISO | Akr1b7 (Mus musculus) | 6480464 | [Methionine co-treated with Choline co-treated with Folic Acid co-treated with Betaine co-treated with Vitamin B 12 co-treated with Zinc co-treated with Phenobarbital] results in increased expression of AKR1B7 mRNA and [Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased expression of AKR1B7 mRNA | CTD | PMID:20938992 and PMID:33549593 | AKR1B15 | Human | cisplatin | increases expression | EXP | | 6480464 | Cisplatin results in increased expression of AKR1B15 mRNA | CTD | PMID:27392435 | AKR1B15 | Human | cisplatin | multiple interactions | EXP | | 6480464 | [Cisplatin co-treated with jinfukang] results in increased expression of AKR1B15 mRNA | CTD | PMID:27392435 | AKR1B15 | Human | clothianidin | increases expression | ISO | Akr1b7 (Mus musculus) | 6480464 | clothianidin results in increased expression of AKR1B7 mRNA | CTD | PMID:33563863 | AKR1B15 | Human | copper(II) sulfate | increases expression | EXP | | 6480464 | Copper Sulfate results in increased expression of AKR1B15 mRNA | CTD | PMID:19549813 | AKR1B15 | Human | cyanocob(III)alamin | multiple interactions | ISO | Akr1b7 (Mus musculus) | 6480464 | [Methionine co-treated with Choline co-treated with Folic Acid co-treated with Betaine co-treated with Vitamin B 12 co-treated with Zinc co-treated with Phenobarbital] results in increased expression of AKR1B7 mRNA | CTD | PMID:33549593 | AKR1B15 | Human | cyproconazole | increases expression | ISO | Akr1b7 (Mus musculus) | 6480464 | cyproconazole results in increased expression of AKR1B7 mRNA | CTD | PMID:22334560 and PMID:23970803 | AKR1B15 | Human | cytarabine | decreases expression | EXP | | 6480464 | Cytarabine results in decreased expression of AKR1B15 mRNA | CTD | PMID:21198554 | AKR1B15 | Human | D-glyceraldehyde | increases metabolic processing | EXP | | 6480464 | AKR1B15 protein results in increased metabolism of Glyceraldehyde | CTD | PMID:21276782 | AKR1B15 | Human | delphinidin | increases expression | ISO | Akr1b7 (Mus musculus) | 6480464 | delphinidin results in increased expression of AKR1B7 mRNA | CTD | PMID:38291899 | AKR1B15 | Human | deoxynivalenol | multiple interactions | ISO | Akr1b7 (Mus musculus) | 6480464 | [Selenomethionine co-treated with deoxynivalenol] results in increased expression of AKR1B7 mRNA | CTD | PMID:38040082 | AKR1B15 | Human | dibenzofurans | decreases expression | ISO | Akr1b7 (Mus musculus) | 6480464 | Dibenzofurans results in decreased expression of AKR1B7 mRNA | CTD | PMID:34254344 | AKR1B15 | Human | diclofenac | multiple interactions | ISO | Akr1b7 (Mus musculus) | 6480464 | [Ibuprofen co-treated with hydroxyibuprofen co-treated with Diclofenac co-treated with Ethinyl Estradiol] results in decreased expression of AKR1B7 mRNA | CTD | PMID:37844793 | AKR1B15 | Human | doramapimod | increases expression | ISO | Akr1b7 (Mus musculus) | 6480464 | doramapimod results in increased expression of AKR1B7 mRNA | CTD | PMID:21328587 | AKR1B15 | Human | epoxiconazole | increases expression | ISO | Akr1b7 (Mus musculus) | 6480464 | epoxiconazole results in increased expression of AKR1B7 mRNA | CTD | PMID:22334560 and PMID:23970803 | AKR1B15 | Human | epoxiconazole | decreases expression | ISO | Akr1b7 (Mus musculus) | 6480464 | epoxiconazole results in decreased expression of AKR1B7 mRNA | CTD | PMID:35436446 | AKR1B15 | Human | ethanol | increases expression | ISO | Akr1b7 (Mus musculus) | 6480464 | Ethanol results in increased expression of AKR1B7 mRNA | CTD | PMID:19167417 | AKR1B15 | Human | flurbiprofen | decreases expression | ISO | Akr1b7 (Mus musculus) | 6480464 | Flurbiprofen results in decreased expression of AKR1B7 mRNA | CTD | PMID:16949054 | AKR1B15 | Human | folic acid | multiple interactions | ISO | Akr1b7 (Mus musculus) | 6480464 | [Methionine co-treated with Choline co-treated with Folic Acid co-treated with Betaine co-treated with Vitamin B 12 co-treated with Zinc co-treated with Phenobarbital] results in increased expression of AKR1B7 mRNA and [Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased expression of AKR1B7 mRNA | CTD | PMID:20938992 and PMID:33549593 | AKR1B15 | Human | fumonisin B1 | increases expression | ISO | Akr1b7 (Mus musculus) | 6480464 | fumonisin B1 results in increased expression of AKR1B7 mRNA | CTD | PMID:16221962 | AKR1B15 | Human | glyceraldehyde | increases metabolic processing | EXP | | 6480464 | AKR1B15 protein results in increased metabolism of Glyceraldehyde | CTD | PMID:21276782 | AKR1B15 | Human | glycine betaine | multiple interactions | ISO | Akr1b7 (Mus musculus) | 6480464 | [Methionine co-treated with Choline co-treated with Folic Acid co-treated with Betaine co-treated with Vitamin B 12 co-treated with Zinc co-treated with Phenobarbital] results in increased expression of AKR1B7 mRNA | CTD | PMID:33549593 | AKR1B15 | Human | GW 4064 | increases expression | ISO | Akr1b7 (Mus musculus) | 6480464 | GW 4064 results in increased expression of AKR1B7 mRNA | CTD | PMID:26655953 | AKR1B15 | Human | ibuprofen | multiple interactions | ISO | Akr1b7 (Mus musculus) | 6480464 | [Ibuprofen co-treated with hydroxyibuprofen co-treated with Diclofenac co-treated with Ethinyl Estradiol] results in decreased expression of AKR1B7 mRNA | CTD | PMID:37844793 | AKR1B15 | Human | inulin | multiple interactions | ISO | Akr1b7 (Mus musculus) | 6480464 | [perfluorooctane sulfonic acid co-treated with Inulin] results in increased expression of AKR1B7 mRNA | CTD | PMID:36331819 | AKR1B15 | Human | L-methionine | multiple interactions | ISO | Akr1b7 (Mus musculus) | 6480464 | [Methionine co-treated with Choline co-treated with Folic Acid co-treated with Betaine co-treated with Vitamin B 12 co-treated with Zinc co-treated with Phenobarbital] results in increased expression of AKR1B7 mRNA and [Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased expression of AKR1B7 mRNA | CTD | PMID:20938992 and PMID:33549593 | AKR1B15 | Human | lipopolysaccharide | multiple interactions | EXP | | 6480464 | [S-(1 and 2-dichlorovinyl)cysteine co-treated with Lipopolysaccharides] results in increased expression of AKR1B15 mRNA | CTD | PMID:35811015 | AKR1B15 | Human | N-nitrosodiethylamine | multiple interactions | ISO | Akr1b7 (Mus musculus) | 6480464 | [Diethylnitrosamine co-treated with Phenobarbital] results in increased expression of AKR1B7 mRNA | CTD | PMID:24535843 | AKR1B15 | Human | N-Nitrosopyrrolidine | increases expression | EXP | | 6480464 | N-Nitrosopyrrolidine results in increased expression of AKR1B15 mRNA | CTD | PMID:32234424 | AKR1B15 | Human | O-methyleugenol | increases expression | EXP | | 6480464 | methyleugenol results in increased expression of AKR1B15 mRNA | CTD | PMID:32234424 | AKR1B15 | Human | PCB138 | multiple interactions | ISO | Akr1b7 (Mus musculus) | 6480464 | [2 more ... | CTD | PMID:25510870 | AKR1B15 | Human | perfluorononanoic acid | multiple interactions | ISO | Akr1b7 (Mus musculus) | 6480464 | [PPARA gene mutant form results in increased susceptibility to perfluoro-n-nonanoic acid] which results in increased expression of AKR1B7 mRNA | CTD | PMID:25949234 | AKR1B15 | Human | perfluorooctane-1-sulfonic acid | increases expression | ISO | Akr1b7 (Mus musculus) | 6480464 | perfluorooctane sulfonic acid results in increased expression of AKR1B7 mRNA | CTD | PMID:27153767 | AKR1B15 | Human | perfluorooctane-1-sulfonic acid | multiple interactions | ISO | Akr1b7 (Mus musculus) | 6480464 | [perfluorooctane sulfonic acid co-treated with Cellulose] results in increased expression of AKR1B7 mRNA more ... | CTD | PMID:36331819 | AKR1B15 | Human | perfluorooctanoic acid | increases expression | ISO | Akr1b7 (Mus musculus) | 6480464 | perfluorooctanoic acid results in increased expression of AKR1B7 mRNA | CTD | PMID:18281256 and PMID:27153767 | AKR1B15 | Human | perfluorooctanoic acid | multiple interactions | ISO | Akr1b7 (Mus musculus) | 6480464 | PPARA protein affects the reaction [perfluorooctanoic acid results in increased expression of AKR1B7 mRNA] | CTD | PMID:18281256 | AKR1B15 | Human | phenobarbital | increases expression | ISO | Akr1b7 (Mus musculus) | 6480464 | Phenobarbital results in increased expression of AKR1B7 mRNA | CTD | PMID:19270015 more ... | AKR1B15 | Human | phenobarbital | multiple interactions | ISO | Akr1b7 (Mus musculus) | 6480464 | [Diethylnitrosamine co-treated with Phenobarbital] results in increased expression of AKR1B7 mRNA more ... | CTD | PMID:19482888 more ... | AKR1B15 | Human | phenobarbital | affects expression | ISO | Akr1b7 (Mus musculus) | 6480464 | Phenobarbital affects the expression of AKR1B7 mRNA | CTD | PMID:19136022 | AKR1B15 | Human | pirinixic acid | multiple interactions | ISO | Akr1b7 (Mus musculus) | 6480464 | [pirinixic acid co-treated with PPARA] results in increased expression of AKR1B7 mRNA | CTD | PMID:20813756 | AKR1B15 | Human | pirinixic acid | increases expression | ISO | Akr1b7 (Mus musculus) | 6480464 | pirinixic acid results in increased expression of AKR1B7 mRNA | CTD | PMID:20813756 and PMID:23811191 | AKR1B15 | Human | pirinixic acid | affects expression | ISO | Akr1b7 (Mus musculus) | 6480464 | pirinixic acid affects the expression of AKR1B7 mRNA | CTD | PMID:19136022 | AKR1B15 | Human | potassium dichromate | increases expression | ISO | Akr1b7 (Mus musculus) | 6480464 | Potassium Dichromate results in increased expression of AKR1B7 mRNA | CTD | PMID:23608068 | AKR1B15 | Human | pregnenolone 16alpha-carbonitrile | increases expression | ISO | Akr1b7 (Mus musculus) | 6480464 | Pregnenolone Carbonitrile results in increased expression of AKR1B7 mRNA | CTD | PMID:25949234 more ... | AKR1B15 | Human | pregnenolone 16alpha-carbonitrile | multiple interactions | ISO | Akr1b7 (Mus musculus) | 6480464 | NR1I2 protein affects the reaction [Pregnenolone Carbonitrile results in increased expression of AKR1B7 mRNA] | CTD | PMID:25949234 | AKR1B15 | Human | propiconazole | increases expression | ISO | Akr1b7 (Mus musculus) | 6480464 | propiconazole results in increased expression of AKR1B7 mRNA | CTD | PMID:21278054 more ... | AKR1B15 | Human | rotenone | increases expression | ISO | Akr1b7 (Mus musculus) | 6480464 | Rotenone results in increased expression of AKR1B7 mRNA | CTD | PMID:19304788 | AKR1B15 | Human | S-(1,2-dichlorovinyl)-L-cysteine | multiple interactions | EXP | | 6480464 | [S-(1 and 2-dichlorovinyl)cysteine co-treated with Lipopolysaccharides] results in increased expression of AKR1B15 mRNA | CTD | PMID:35811015 | AKR1B15 | Human | selenomethionine | multiple interactions | ISO | Akr1b7 (Mus musculus) | 6480464 | [Selenomethionine co-treated with deoxynivalenol] results in increased expression of AKR1B7 mRNA | CTD | PMID:38040082 | AKR1B15 | Human | silver atom | increases expression | ISO | Akr1b7 (Mus musculus) | 6480464 | Silver results in increased expression of AKR1B7 mRNA | CTD | PMID:27131904 | AKR1B15 | Human | silver(0) | increases expression | ISO | Akr1b7 (Mus musculus) | 6480464 | Silver results in increased expression of AKR1B7 mRNA | CTD | PMID:27131904 | AKR1B15 | Human | sodium arsenite | increases expression | EXP | | 6480464 | sodium arsenite results in increased expression of AKR1B15 mRNA | CTD | PMID:28595984 and PMID:34032870 | AKR1B15 | Human | sodium fluoride | decreases expression | ISO | Akr1b7 (Mus musculus) | 6480464 | Sodium Fluoride results in decreased expression of AKR1B7 protein | CTD | PMID:28918527 | AKR1B15 | Human | temozolomide | decreases expression | EXP | | 6480464 | Temozolomide results in decreased expression of AKR1B15 mRNA | CTD | PMID:31758290 | AKR1B15 | Human | titanium dioxide | decreases expression | ISO | Akr1b7 (Mus musculus) | 6480464 | titanium dioxide results in decreased expression of AKR1B7 mRNA | CTD | PMID:23131501 | AKR1B15 | Human | titanium dioxide | increases expression | ISO | Akr1b7 (Mus musculus) | 6480464 | titanium dioxide results in increased expression of AKR1B7 mRNA | CTD | PMID:23557971 | AKR1B15 | Human | tributylstannane | increases expression | ISO | Akr1b7 (Mus musculus) | 6480464 | tributyltin results in increased expression of AKR1B7 mRNA | CTD | PMID:31939706 | AKR1B15 | Human | trichloroethene | increases expression | ISO | Akr1b7 (Mus musculus) | 6480464 | Trichloroethylene results in increased expression of AKR1B7 mRNA | CTD | PMID:25549359 | AKR1B15 | Human | troglitazone | increases expression | EXP | | 6480464 | troglitazone results in increased expression of AKR1B15 mRNA | CTD | PMID:25572481 | AKR1B15 | Human | trovafloxacin | decreases expression | ISO | Akr1b7 (Mus musculus) | 6480464 | trovafloxacin results in decreased expression of AKR1B7 mRNA | CTD | PMID:35537566 | AKR1B15 | Human | urethane | decreases expression | EXP | | 6480464 | Urethane results in decreased expression of AKR1B15 mRNA | CTD | PMID:28818685 | AKR1B15 | Human | zinc atom | multiple interactions | ISO | Akr1b7 (Mus musculus) | 6480464 | [Methionine co-treated with Choline co-treated with Folic Acid co-treated with Betaine co-treated with Vitamin B 12 co-treated with Zinc co-treated with Phenobarbital] results in increased expression of AKR1B7 mRNA | CTD | PMID:33549593 | AKR1B15 | Human | zinc(0) | multiple interactions | ISO | Akr1b7 (Mus musculus) | 6480464 | [Methionine co-treated with Choline co-treated with Folic Acid co-treated with Betaine co-treated with Vitamin B 12 co-treated with Zinc co-treated with Phenobarbital] results in increased expression of AKR1B7 mRNA | CTD | PMID:33549593 | |