Ptpn5 (protein tyrosine phosphatase, non-receptor type 5) - Rat Genome Database

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Gene: Ptpn5 (protein tyrosine phosphatase, non-receptor type 5) Rattus norvegicus
Analyze
Symbol: Ptpn5
Name: protein tyrosine phosphatase, non-receptor type 5
RGD ID: 3448
Description: Enables identical protein binding activity and protein tyrosine phosphatase activity. Involved in several processes, including positive regulation of cellular component organization; positive regulation of establishment of protein localization; and positive regulation of long-term synaptic potentiation. Located in several cellular components, including perikaryon; proximal dendrite; and synaptic vesicle. Used to study transient cerebral ischemia. Biomarker of transient cerebral ischemia. Orthologous to human PTPN5 (protein tyrosine phosphatase non-receptor type 5); PARTICIPATES IN dopamine signaling pathway; mitogen activated protein kinase signaling pathway; INTERACTS WITH (-)-anisomycin; 2,2',5,5'-tetrachlorobiphenyl; 2,3,7,8-tetrachlorodibenzodioxine.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: neural-specific protein-tyrosine phosphatase; protein-tyrosine phosphatase striatum-enriched; protein-tyrosine-phosphatase non-receptor 5; STEP; striatum-enriched protein-tyrosine phosphatase; tyrosine-protein phosphatase non-receptor type 5
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Black Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81106,756,896 - 106,817,369 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl1106,756,896 - 106,816,828 (-)EnsemblGRCr8
mRatBN7.2197,620,638 - 97,681,186 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl197,620,642 - 97,679,882 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx1103,010,604 - 103,069,779 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01111,482,589 - 111,541,753 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01104,768,970 - 104,828,192 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.01103,197,918 - 103,258,309 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1103,197,915 - 103,256,823 (-)Ensemblrn6Rnor6.0
Rnor_5.01104,263,139 - 104,321,833 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.4197,629,192 - 97,643,225 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera191,865,125 - 91,880,882 (-)NCBICelera
RGSC_v3.1197,707,302 - 97,721,336 (-)NCBI
Cytogenetic Map1q22NCBI
JBrowse:




Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-pilocarpine  (ISO)
(-)-anisomycin  (EXP)
1,2-dimethylhydrazine  (ISO)
2,2',5,5'-tetrachlorobiphenyl  (EXP)
2,3,7,8-tetrachlorodibenzodioxine  (EXP)
2,3,7,8-Tetrachlorodibenzofuran  (EXP)
4,4'-sulfonyldiphenol  (EXP,ISO)
4-vinylcyclohexene dioxide  (ISO)
6-propyl-2-thiouracil  (EXP)
acrylamide  (ISO)
aflatoxin B1  (ISO)
Aflatoxin B2 alpha  (ISO)
ammonium chloride  (EXP)
Ampullosporin  (EXP)
arsenite(3-)  (ISO)
atenolol  (EXP)
atrazine  (ISO)
belinostat  (ISO)
benzo[a]pyrene  (ISO)
benzo[b]fluoranthene  (ISO)
bis(2-ethylhexyl) phthalate  (ISO)
bisphenol A  (EXP)
bisphenol F  (EXP)
Butylbenzyl phthalate  (ISO)
cantharidin  (ISO)
carbon nanotube  (ISO)
CGP 52608  (ISO)
chlordecone  (ISO)
chlorpyrifos  (ISO)
chrysene  (ISO)
Cuprizon  (EXP)
cycloheximide  (EXP)
dibutyl phthalate  (ISO)
diethyl phthalate  (ISO)
diisobutyl phthalate  (ISO)
diisononyl phthalate  (ISO)
dorsomorphin  (ISO)
entinostat  (ISO)
ethanol  (ISO)
fenvalerate  (EXP)
folic acid  (ISO)
fulvestrant  (ISO)
genistein  (ISO)
iron dichloride  (ISO)
isoprenaline  (EXP)
ketamine  (EXP)
LY294002  (EXP)
manganese(II) chloride  (EXP)
methamphetamine  (EXP)
methoxychlor  (ISO)
N-methyl-4-phenylpyridinium  (EXP)
panobinostat  (ISO)
PCB138  (EXP)
phenylmercury acetate  (ISO)
propranolol  (EXP)
SB 431542  (ISO)
sirolimus  (EXP)
SL-327  (EXP)
sodium arsenite  (ISO)
tacrolimus hydrate  (ISO)
tamoxifen  (ISO)
tetrachloromethane  (EXP)
tetraphene  (ISO)
titanium dioxide  (ISO)
trichostatin A  (ISO)
triptonide  (ISO)
trovafloxacin  (ISO)
valproic acid  (ISO)
vorinostat  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Insights into the mechanisms of gastric adaptation to aspirin-induced injury: a role for regenerating protein but not trefoil peptides. Alderman BM, etal., Lab Invest. 2003 Oct;83(10):1415-25.
2. The physiology, signaling, and pharmacology of dopamine receptors. Beaulieu JM and Gainetdinov RR, Pharmacol Rev. 2011 Mar;63(1):182-217. doi: 10.1124/pr.110.002642. Epub 2011 Feb 8.
3. Cellular and molecular characterization of a brain-enriched protein tyrosine phosphatase. Boulanger LM, etal., J Neurosci. 1995 Feb;15(2):1532-44.
4. STEP61: a member of a family of brain-enriched PTPs is localized to the endoplasmic reticulum. Bult A, etal., J Neurosci. 1996 Dec 15;16(24):7821-31.
5. Fyn kinase induces synaptic and cognitive impairments in a transgenic mouse model of Alzheimer's disease. Chin J, etal., J Neurosci. 2005 Oct 19;25(42):9694-703.
6. Neuroprotective role of a brain-enriched tyrosine phosphatase, STEP, in focal cerebral ischemia. Deb I, etal., J Neurosci. 2013 Nov 6;33(45):17814-26. doi: 10.1523/JNEUROSCI.2346-12.2013.
7. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
8. Hypoxia-ischemia in perinatal rat brain induces the formation of a low molecular weight isoform of striatal enriched tyrosine phosphatase (STEP). Gurd JW, etal., J Neurochem. 1999 Nov;73(5):1990-4.
9. Cellular distribution of AMPA receptor subunits and mGlu5 following acute and repeated administration of morphine or methamphetamine. Herrold AA, etal., J Neurochem. 2013 Aug;126(4):503-17. doi: 10.1111/jnc.12323. Epub 2013 Jun 18.
10. Translation of striatal-enriched protein tyrosine phosphatase (STEP) after beta1-adrenergic receptor stimulation. Hu Y, etal., J Neurochem. 2007 Oct;103(2):531-41. Epub 2007 Jul 10.
11. Abeta-mediated NMDA receptor endocytosis in Alzheimer's disease involves ubiquitination of the tyrosine phosphatase STEP61. Kurup P, etal., J Neurosci. 2010 Apr 28;30(17):5948-57. doi: 10.1523/JNEUROSCI.0157-10.2010.
12. A protein tyrosine phosphatase expressed within dopaminoceptive neurons of the basal ganglia and related structures. Lombroso PJ, etal., J Neurosci. 1993 Jul;13(7):3064-74.
13. Molecular characterization of a protein-tyrosine-phosphatase enriched in striatum. Lombroso PJ, etal., Proc Natl Acad Sci U S A 1991 Aug 15;88(16):7242-6.
14. Stimulated regeneration of the crushed adult rat optic nerve correlates with attenuated expression of the protein tyrosine phosphatases RPTPalpha, STEP, and LAR. Lorber B, etal., Mol Cell Neurosci. 2004 Dec;27(4):404-16.
15. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
16. Overexpression of striatal enriched phosphatase (STEP) promotes the neurite outgrowth induced by a cAMP analogue in PC12 cells. Okamura A, etal., Brain Res Mol Brain Res. 1999 Apr 6;67(1):1-9.
17. NMDA-mediated activation of the tyrosine phosphatase STEP regulates the duration of ERK signaling. Paul S, etal., Nat Neurosci. 2003 Jan;6(1):34-42.
18. Tyrosine phosphatase STEP is a tonic brake on induction of long-term potentiation. Pelkey KA, etal., Neuron. 2002 Mar 28;34(1):127-38.
19. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
20. PTP-SL and STEP protein tyrosine phosphatases regulate the activation of the extracellular signal-regulated kinases ERK1 and ERK2 by association through a kinase interaction motif. Pulido R, etal., EMBO J. 1998 Dec 15;17(24):7337-50.
21. Aging is associated with dimerization and inactivation of the brain-enriched tyrosine phosphatase STEP. Rajagopal S, etal., Neurobiol Aging. 2016 May;41:25-38. doi: 10.1016/j.neurobiolaging.2016.02.004. Epub 2016 Feb 12.
22. GOA pipeline RGD automated data pipeline
23. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
24. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
25. A substrate trapping mutant form of striatal-enriched protein tyrosine phosphatase prevents amphetamine-induced stereotypies and long-term potentiation in the striatum. Tashev R, etal., Biol Psychiatry. 2009 Apr 15;65(8):637-45. doi: 10.1016/j.biopsych.2008.10.008. Epub 2008 Nov 20.
26. Tentative Sequence Identification Numbers Tentative Sequence Data IDs. TIGR Gene Index, Rat Data
27. Extrasynaptic NMDA receptors couple preferentially to excitotoxicity via calpain-mediated cleavage of STEP. Xu J, etal., J Neurosci. 2009 Jul 22;29(29):9330-43. doi: 10.1523/JNEUROSCI.2212-09.2009.
28. Novelty exploration elicits a reversal of acute stress-induced modulation of hippocampal synaptic plasticity in the rat. Yang CH, etal., J Physiol. 2006 Dec 1;577(Pt 2):601-15. Epub 2006 Sep 28.
29. Genetic reduction of striatal-enriched tyrosine phosphatase (STEP) reverses cognitive and cellular deficits in an Alzheimer's disease mouse model. Zhang Y, etal., Proc Natl Acad Sci U S A. 2010 Nov 2;107(44):19014-9. doi: 10.1073/pnas.1013543107. Epub 2010 Oct 18.
Additional References at PubMed
PMID:12477932   PMID:16025111   PMID:16441242   PMID:18445231   PMID:21029094   PMID:22435660   PMID:25583483   PMID:25951993   PMID:26391783   PMID:26574547   PMID:27457929   PMID:27857196  
PMID:28466270   PMID:32707818   PMID:39438980  


Genomics

Comparative Map Data
Ptpn5
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81106,756,896 - 106,817,369 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl1106,756,896 - 106,816,828 (-)EnsemblGRCr8
mRatBN7.2197,620,638 - 97,681,186 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl197,620,642 - 97,679,882 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx1103,010,604 - 103,069,779 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01111,482,589 - 111,541,753 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01104,768,970 - 104,828,192 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.01103,197,918 - 103,258,309 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1103,197,915 - 103,256,823 (-)Ensemblrn6Rnor6.0
Rnor_5.01104,263,139 - 104,321,833 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.4197,629,192 - 97,643,225 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera191,865,125 - 91,880,882 (-)NCBICelera
RGSC_v3.1197,707,302 - 97,721,336 (-)NCBI
Cytogenetic Map1q22NCBI
PTPN5
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381118,727,928 - 18,792,721 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1118,727,928 - 18,792,721 (-)Ensemblhg38GRCh38
GRCh371118,749,475 - 18,814,268 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361118,706,051 - 18,769,965 (-)NCBIBuild 36Build 36hg18NCBI36
Build 341118,706,052 - 18,769,874NCBI
Celera1118,885,312 - 18,948,746 (-)NCBICelera
Cytogenetic Map11p15.1NCBI
HuRef1118,434,330 - 18,498,764 (-)NCBIHuRef
CHM1_11118,748,812 - 18,813,611 (-)NCBICHM1_1
T2T-CHM13v2.01118,825,966 - 18,890,761 (-)NCBIT2T-CHM13v2.0
Ptpn5
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39746,727,543 - 46,783,774 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl746,727,543 - 46,783,432 (-)EnsemblGRCm39 EnsemblGRCm39
GRCm38747,077,795 - 47,134,026 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl747,077,795 - 47,133,684 (-)Ensemblmm10GRCm38
MGSCv37754,333,168 - 54,389,054 (-)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv36746,945,824 - 47,001,706 (-)NCBIMGSCv36mm8
Celera742,560,280 - 42,616,180 (-)NCBICelera
Cytogenetic Map7B3NCBI
cM Map730.7NCBI
Ptpn5
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495541433,377,322 - 33,437,118 (-)Ensembl
ChiLan1.0NW_00495541433,381,783 - 33,436,974 (-)NCBIChiLan1.0ChiLan1.0
PTPN5
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2921,037,528 - 21,101,209 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11120,997,916 - 21,061,597 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01118,758,285 - 18,822,845 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11118,672,360 - 18,737,167 (-)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1118,673,366 - 18,711,885 (-)EnsemblpanPan2panpan1.1
PTPN5
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12141,097,563 - 41,154,247 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2141,097,569 - 41,136,706 (-)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha2140,576,516 - 40,632,837 (-)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.02142,220,694 - 42,277,125 (-)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl2142,137,874 - 42,277,086 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.12141,223,899 - 41,280,192 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02141,401,047 - 41,457,402 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02141,778,556 - 41,834,892 (-)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Ptpn5
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440494744,491,082 - 44,552,326 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_004936528525,769 - 586,327 (+)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_004936528523,884 - 586,306 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
PTPN5
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl240,459,049 - 40,521,461 (+)EnsemblsusScr11Sscrofa11.1
Sscrofa11.1240,458,865 - 40,521,470 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2243,468,196 - 43,530,692 (+)NCBISscrofa10.2Sscrofa10.2susScr3
PTPN5
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1146,134,109 - 46,197,246 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl146,153,340 - 46,199,002 (+)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Vero_WHO_p1.0NW_023666038143,475,470 - 143,539,473 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Ptpn5
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462476610,147,840 - 10,204,238 (-)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
HetGla 1.0NW_00462476610,147,859 - 10,204,657 (-)NCBIHetGla 1.0HetGla 1.0hetGla2
Ptpn5
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v12152,239,601 - 152,296,567 (+)NCBIRrattus_CSIRO_v1

Variants

.
Variants in Ptpn5
323 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:513
Count of miRNA genes:250
Interacting mature miRNAs:302
Transcripts:ENSRNOT00000018860
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1582234Gluco18Glucose level QTL 183.40.0003blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)187889942132889942Rat
1358359Sradr1Stress Responsive Adrenal Weight QTL 14.74adrenal gland mass (VT:0010420)both adrenal glands wet weight (CMO:0000164)139728272132889942Rat
634314Niddm44Non-insulin dependent diabetes mellitus QTL 44blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)151941022208479811Rat
1331793Bp200Blood pressure QTL 2003.71601arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1102780511182384005Rat
1578654Bss10Bone structure and strength QTL 104femur morphology trait (VT:0000559)femoral neck cortical cross-sectional area (CMO:0001702)151940904168768703Rat
2300324Fetw1Fetal weight QTL 112.10.005fetal growth trait (VT:0004201)fetal body weight (CMO:0002080)192963855109494029Rat
1554320Bmd1Bone mineral density QTL 112.20.0001femur mineral mass (VT:0010011)volumetric bone mineral density (CMO:0001553)1101228864146228864Rat
1331800Scl25Serum cholesterol level QTL 253.013blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)187785026142582336Rat
7421628Bp361Blood pressure QTL 3610.001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)183019780128019780Rat
631495Bp96Blood pressure QTL 964.52arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)166404680111404680Rat
70225Bp58Blood pressure QTL 583.3arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)134184556172281316Rat
2298545Neuinf8Neuroinflammation QTL 84.6nervous system integrity trait (VT:0010566)spinal cord beta-2 microglobulin mRNA level (CMO:0002125)166009857160501508Rat
10059597Bp377Blood pressure QTL 3773.420.025arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)134565911208798288Rat
631519Pia11Pristane induced arthritis QTL 115.3joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)193903998191260518Rat
1302788Scl19Serum cholesterol QTL 194.60.001blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)166400974132889942Rat
1549903Bp267Blood pressure QTL 267arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)184107164115183752Rat
2313083Bmd74Bone mineral density QTL 7440.0001tibia mineral mass (VT:1000283)total volumetric bone mineral density (CMO:0001728)191302413136302413Rat
2313402Anxrr24Anxiety related response QTL 24aggression-related behavior trait (VT:0015014)tameness/aggressiveness composite score (CMO:0002136)151511344153680016Rat
724567Tcas6Tongue tumor susceptibility QTL 66.85tongue integrity trait (VT:0010553)number of squamous cell tumors of the tongue with diameter greater than 3 mm (CMO:0001950)1102359314153680016Rat
724521Uae1Urinary albumin excretion QTL 13.80.0001urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)199645382182701046Rat
1358902Bw47Body weight QTL 471.67body mass (VT:0001259)body weight (CMO:0000012)199645382221502378Rat
1358192Ept13Estrogen-induced pituitary tumorigenesis QTL 133.4pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)186622262131622262Rat
2300164Bmd44Bone mineral density QTL 445.40.0001lumbar vertebra mineral mass (VT:0010511)volumetric bone mineral density (CMO:0001553)166077886111077886Rat
731168Bp154Blood pressure QTL 1543.4arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1103779152223964440Rat
631205Bp196Blood pressure QTL 19640.0001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)198879955208479939Rat
738022Anxrr13Anxiety related response QTL 134.60.00039locomotor behavior trait (VT:0001392)measurement of voluntary locomotion into, out of, or within a discrete space in an open field apparatus (CMO:0001514)192683681137683681Rat
152025249Scl82Serum cholesterol level QTL 824.77blood cholesterol amount (VT:0000180)152891222109116986Rat
10054135Gmadr2Adrenal mass QTL 21.970.0129adrenal gland mass (VT:0010420)both adrenal glands wet weight (CMO:0000164)186993904131993904Rat
7411712Strs4Sensitivity to stroke QTL 48.7cerebrum integrity trait (VT:0010549)percentage of study population developing cerebrovascular lesions during a period of time (CMO:0000932)187558587132558587Rat
1331749Hrtrt11Heart rate QTL 112.973heart pumping trait (VT:2000009)heart rate (CMO:0000002)192683681137683681Rat
737977Bp160Blood pressure QTL 1600.001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)197582336142582336Rat
2293142Bp314Blood pressure QTL 314arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1101594089146594089Rat
61433Cia2Collagen induced arthritis QTL 25joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1100345976145345976Rat
724529Cm16Cardiac mass QTL 162.7heart mass (VT:0007028)calculated heart weight (CMO:0000073)196717367160111531Rat

Markers in Region
RH132351  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2197,620,702 - 97,620,890 (+)MAPPERmRatBN7.2
Rnor_6.01103,197,983 - 103,198,170NCBIRnor6.0
Rnor_5.01104,263,204 - 104,263,391UniSTSRnor5.0
RGSC_v3.4197,629,254 - 97,629,441UniSTSRGSC3.4
Celera191,865,187 - 91,865,374UniSTS
Cytogenetic Map1q22UniSTS
U28216  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2197,626,059 - 97,626,253 (+)MAPPERmRatBN7.2
Rnor_6.01103,203,336 - 103,203,529NCBIRnor6.0
Rnor_5.01104,268,156 - 104,268,349UniSTSRnor5.0
RGSC_v3.4197,634,531 - 97,634,724UniSTSRGSC3.4
Celera191,872,230 - 91,872,423UniSTS
Cytogenetic Map1q22UniSTS
U28217  
Rat AssemblyChrPosition (strand)SourceJBrowse
GRCr81106,757,551 - 106,757,722 (+)Marker Load Pipeline
mRatBN7.2197,621,293 - 97,621,464 (+)MAPPERmRatBN7.2
Rnor_6.01103,198,574 - 103,198,744NCBIRnor6.0
Rnor_5.01104,263,795 - 104,263,965UniSTSRnor5.0
RGSC_v3.4197,629,845 - 97,630,015UniSTSRGSC3.4
Celera191,865,778 - 91,865,948UniSTS
Cytogenetic Map1q22UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
16 10 60 149 48 43 21 56 21 6 244 147 10 122 53 87 22 13 13

Sequence

Nucleotide Sequences
RefSeq Transcripts NM_001398605 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006229253 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006229254 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006229255 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006229257 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_008759346 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017589064 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039109683 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039109687 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039109691 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039109694 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039109698 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039109699 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039109703 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063287745 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063287757 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide BC092196 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH473979 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ211673 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ213308 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JAXUCZ010000001 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  S49400 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Ensembl Acc Id: ENSRNOT00000018860   ⟹   ENSRNOP00000018860
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1106,756,896 - 106,816,134 (-)Ensembl
mRatBN7.2 Ensembl197,620,642 - 97,679,882 (-)Ensembl
Rnor_6.0 Ensembl1103,197,915 - 103,256,823 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000134129   ⟹   ENSRNOP00000111270
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1106,756,896 - 106,816,828 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000142551   ⟹   ENSRNOP00000099803
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1106,756,896 - 106,816,134 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000145318   ⟹   ENSRNOP00000099754
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1106,756,896 - 106,796,362 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000149929   ⟹   ENSRNOP00000100808
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1106,757,184 - 106,816,134 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000165423   ⟹   ENSRNOP00000107278
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1106,756,896 - 106,815,833 (-)Ensembl
RefSeq Acc Id: NM_001398605   ⟹   NP_001385534
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81106,756,896 - 106,816,134 (-)NCBI
mRatBN7.2197,620,638 - 97,679,882 (-)NCBI
RefSeq Acc Id: XM_006229254   ⟹   XP_006229316
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81106,756,896 - 106,816,369 (-)NCBI
mRatBN7.2197,620,638 - 97,680,134 (-)NCBI
Rnor_6.01103,197,918 - 103,257,368 (-)NCBI
Rnor_5.01104,263,139 - 104,321,833 (-)NCBI
Sequence:
RefSeq Acc Id: XM_006229257   ⟹   XP_006229319
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81106,756,896 - 106,816,366 (-)NCBI
mRatBN7.2197,620,638 - 97,680,132 (-)NCBI
Rnor_6.01103,197,918 - 103,257,367 (-)NCBI
Rnor_5.01104,263,139 - 104,321,833 (-)NCBI
Sequence:
RefSeq Acc Id: XM_039109683   ⟹   XP_038965611
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81106,756,896 - 106,816,386 (-)NCBI
mRatBN7.2197,620,638 - 97,680,163 (-)NCBI
RefSeq Acc Id: XM_039109687   ⟹   XP_038965615
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81106,756,896 - 106,817,368 (-)NCBI
mRatBN7.2197,620,638 - 97,681,185 (-)NCBI
RefSeq Acc Id: XM_039109691   ⟹   XP_038965619
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81106,756,896 - 106,816,387 (-)NCBI
mRatBN7.2197,620,638 - 97,680,165 (-)NCBI
RefSeq Acc Id: XM_039109694   ⟹   XP_038965622
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81106,756,896 - 106,817,369 (-)NCBI
mRatBN7.2197,620,638 - 97,681,186 (-)NCBI
RefSeq Acc Id: XM_039109698   ⟹   XP_038965626
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81106,756,896 - 106,814,946 (-)NCBI
mRatBN7.2197,620,638 - 97,678,693 (-)NCBI
RefSeq Acc Id: XM_039109699   ⟹   XP_038965627
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81106,756,896 - 106,816,391 (-)NCBI
mRatBN7.2197,620,638 - 97,680,167 (-)NCBI
RefSeq Acc Id: XM_039109703   ⟹   XP_038965631
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81106,756,896 - 106,816,383 (-)NCBI
mRatBN7.2197,620,638 - 97,680,157 (-)NCBI
RefSeq Acc Id: XM_063287745   ⟹   XP_063143815
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81106,756,896 - 106,808,036 (-)NCBI
RefSeq Acc Id: XM_063287757   ⟹   XP_063143827
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81106,756,896 - 106,817,357 (-)NCBI
RefSeq Acc Id: XP_006229316   ⟸   XM_006229254
- Peptide Label: isoform X5
- Sequence:
RefSeq Acc Id: XP_006229319   ⟸   XM_006229257
- Peptide Label: isoform X6
- Sequence:
Ensembl Acc Id: ENSRNOP00000018860   ⟸   ENSRNOT00000018860
RefSeq Acc Id: XP_038965622   ⟸   XM_039109694
- Peptide Label: isoform X2
RefSeq Acc Id: XP_038965615   ⟸   XM_039109687
- Peptide Label: isoform X1
RefSeq Acc Id: XP_038965627   ⟸   XM_039109699
- Peptide Label: isoform X3
RefSeq Acc Id: XP_038965619   ⟸   XM_039109691
- Peptide Label: isoform X2
RefSeq Acc Id: XP_038965611   ⟸   XM_039109683
- Peptide Label: isoform X1
RefSeq Acc Id: XP_038965631   ⟸   XM_039109703
- Peptide Label: isoform X4
RefSeq Acc Id: XP_038965626   ⟸   XM_039109698
- Peptide Label: isoform X2
RefSeq Acc Id: NP_001385534   ⟸   NM_001398605
- UniProtKB: A0A0G2QC31 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063143827   ⟸   XM_063287757
- Peptide Label: isoform X5
RefSeq Acc Id: XP_063143815   ⟸   XM_063287745
- Peptide Label: isoform X2
Ensembl Acc Id: ENSRNOP00000100808   ⟸   ENSRNOT00000149929
Ensembl Acc Id: ENSRNOP00000107278   ⟸   ENSRNOT00000165423
Ensembl Acc Id: ENSRNOP00000111270   ⟸   ENSRNOT00000134129
Ensembl Acc Id: ENSRNOP00000099803   ⟸   ENSRNOT00000142551
Ensembl Acc Id: ENSRNOP00000099754   ⟸   ENSRNOT00000145318
Protein Domains
Tyrosine specific protein phosphatases   Tyrosine-protein phosphatase

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P35234-F1-model_v2 AlphaFold P35234 1-369 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:3448 AgrOrtholog
BioCyc Gene G2FUF-59595 BioCyc
Ensembl Genes ENSRNOG00000013981 Ensembl, ENTREZGENE
Ensembl Transcript ENSRNOT00000018860 ENTREZGENE
  ENSRNOT00000134129 ENTREZGENE
  ENSRNOT00000145318 ENTREZGENE
  ENSRNOT00000165423 ENTREZGENE
Gene3D-CATH 3.90.190.10 UniProtKB/Swiss-Prot
IMAGE_CLONE IMAGE:7313460 IMAGE-MGC_LOAD
InterPro Prot-tyrosine_phosphatase-like UniProtKB/Swiss-Prot
  PTPase_domain UniProtKB/Swiss-Prot
  Tyr_Pase_AS UniProtKB/Swiss-Prot
  Tyr_Pase_cat UniProtKB/Swiss-Prot
  Tyr_Pase_KIM-con UniProtKB/Swiss-Prot
  TYR_PHOSPHATASE_dom UniProtKB/Swiss-Prot
MGC_CLONE MGC:105445 IMAGE-MGC_LOAD
NCBI Gene 29644 ENTREZGENE
PANTHER PTHR46198 UniProtKB/Swiss-Prot
  TYROSINE-PROTEIN PHOSPHATASE NON-RECEPTOR TYPE 5 UniProtKB/Swiss-Prot
Pfam Y_phosphatase UniProtKB/Swiss-Prot
PhenoGen Ptpn5 PhenoGen
PRINTS KIMPTPASE UniProtKB/Swiss-Prot
  PRTYPHPHTASE UniProtKB/Swiss-Prot
PROSITE TYR_PHOSPHATASE_1 UniProtKB/Swiss-Prot
  TYR_PHOSPHATASE_2 UniProtKB/Swiss-Prot
  TYR_PHOSPHATASE_PTP UniProtKB/Swiss-Prot
RatGTEx ENSRNOG00000013981 RatGTEx
SMART PTPc UniProtKB/Swiss-Prot
  PTPc_motif UniProtKB/Swiss-Prot
Superfamily-SCOP SSF52799 UniProtKB/Swiss-Prot
TIGR TC232484
UniProt A0A0G2QC31 ENTREZGENE, UniProtKB/TrEMBL
  A0ABK0L6W1_RAT UniProtKB/TrEMBL
  A0ABK0L7E4_RAT UniProtKB/TrEMBL
  A0ABK0L9M8_RAT UniProtKB/TrEMBL
  A0ABK0LQM0_RAT UniProtKB/TrEMBL
  A0ABK0M295_RAT UniProtKB/TrEMBL
  A6JBE5_RAT UniProtKB/TrEMBL
  P35234 ENTREZGENE, UniProtKB/Swiss-Prot
  Q56A30_RAT UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2002-06-10 Ptpn5  protein tyrosine phosphatase, non-receptor type 5      Name updated 70584 APPROVED

RGD Curation Notes
Note Type Note Reference
gene_domains contains a myristoylation amino acid-consensus sequence at the N terminus of the protein 69950