Ptk2 (protein tyrosine kinase 2) - Rat Genome Database

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Gene: Ptk2 (protein tyrosine kinase 2) Rattus norvegicus
Analyze
Symbol: Ptk2
Name: protein tyrosine kinase 2
RGD ID: 3443
Description: Enables several functions, including identical protein binding activity; integrin binding activity; and phosphatidylinositol 3-kinase binding activity. Involved in several processes, including cellular response to morphine; positive regulation of cell population proliferation; and regulation of cell migration. Located in several cellular components, including basolateral plasma membrane; focal adhesion; and intercalated disc. Is active in glutamatergic synapse and postsynapse. Used to study hepatocellular carcinoma; hypertension; and nephritis. Biomarker of hypertension; ischemia; and uremia. Human ortholog(s) of this gene implicated in leiomyoma; lung small cell carcinoma; and pulmonary hypertension. Orthologous to human PTK2 (protein tyrosine kinase 2); PARTICIPATES IN long term potentiation; integrin mediated signaling pathway; vascular endothelial growth factor signaling pathway; INTERACTS WITH 1-octadec-9-enoylglycero-3-phosphate; 2,3,7,8-tetrachlorodibenzodioxine; 2,4-dinitrotoluene.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: FADK 1; FAK; focal adhesion kinase; focal adhesion kinase 1; focal adhesion kinase-related nonkinase; FRNK; p125FAK; pp125FAK; Protein tyrosine kinase; protein-tyrosine kinase 2; PTK2 protein tyrosine kinase 2
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr87107,015,730 - 107,220,865 (-)NCBIGRCr8
mRatBN7.27105,126,725 - 105,331,848 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl7105,126,728 - 105,331,783 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx7106,875,344 - 107,035,378 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.07109,096,927 - 109,256,959 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.07109,044,956 - 109,204,985 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.07114,436,419 - 114,611,317 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl7114,437,361 - 114,590,119 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.07114,371,979 - 114,525,553 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.47110,933,298 - 111,084,554 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.17110,967,527 - 111,118,784 (-)NCBI
Celera7101,534,957 - 101,690,471 (-)NCBICelera
RH 3.4 Map7725.6RGD
Cytogenetic Map7q34NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-catechin  (ISO)
(+)-pilocarpine  (ISO)
(-)-epigallocatechin 3-gallate  (ISO)
(S)-nicotine  (ISO)
1,2-dimethylhydrazine  (ISO)
1,4-dithiothreitol  (ISO)
1,8-cineole  (ISO)
1-octadec-9-enoylglycero-3-phosphate  (EXP,ISO)
17alpha-ethynylestradiol  (ISO)
17beta-estradiol  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,4-dinitrotoluene  (EXP)
3'-amino-3'-deoxy-N(6),N(6)-dimethyladenosine  (EXP)
3,4-methylenedioxymethamphetamine  (ISO)
3-\{1-[3-(dimethylamino)propyl]-1H-indol-3-yl\}-4-(1H-indol-3-yl)-1H-pyrrole-2,5-dione  (EXP)
3-methylcholanthrene  (ISO)
3H-1,2-dithiole-3-thione  (EXP)
4,4'-sulfonyldiphenol  (ISO)
4-(N-nitrosomethylamino)-1-(3-pyridyl)butan-1-one  (ISO)
4-hydroxycoumarin  (ISO)
4-hydroxynon-2-enal  (ISO)
4-tert-Octylphenol  (ISO)
5-fluorouracil  (ISO)
8-Br-cAMP  (ISO)
acrylamide  (ISO)
actinomycin D  (EXP)
aflatoxin B1  (ISO)
aldehydo-D-glucose  (EXP,ISO)
all-trans-retinoic acid  (ISO)
alpha-naphthoflavone  (ISO)
aluminium oxide  (ISO)
AM-251  (ISO)
ammonium chloride  (EXP,ISO)
amosite asbestos  (ISO)
Anetholtrithion  (ISO)
antirheumatic drug  (ISO)
aristolochic acid A  (ISO)
arsane  (EXP,ISO)
arsenic atom  (EXP,ISO)
arsenite(3-)  (ISO)
atrazine  (EXP,ISO)
atropine  (ISO)
barium(0)  (ISO)
benzene  (ISO)
benzo[a]pyrene  (ISO)
benzo[a]pyrene diol epoxide I  (ISO)
beta-lapachone  (ISO)
bis(2-ethylhexyl) phthalate  (ISO)
bisphenol A  (EXP,ISO)
bisphenol F  (ISO)
blebbistatin  (ISO)
BQ 123  (ISO)
bufalin  (ISO)
Butylbenzyl phthalate  (ISO)
cadmium atom  (ISO)
cadmium dichloride  (ISO)
caffeine  (ISO)
calyculin a  (ISO)
cannabidiol  (ISO)
capsaicin  (ISO)
carbamazepine  (ISO)
carbon nanotube  (ISO)
carvone  (ISO)
casticin  (ISO)
CGP 52608  (ISO)
chelerythrine  (EXP)
chlorpyrifos  (EXP)
chromium(6+)  (ISO)
chrysin  (ISO)
cisplatin  (EXP,ISO)
clozapine  (ISO)
cocaine  (ISO)
copper atom  (EXP,ISO)
copper(0)  (EXP,ISO)
cordycepin  (ISO)
crocidolite asbestos  (ISO)
cyclosporin A  (ISO)
D-glucose  (EXP,ISO)
D-mannitol  (ISO)
daidzein  (ISO)
deguelin  (ISO)
Di-n-octyl phthalate  (ISO)
diallyl trisulfide  (ISO)
dibenzo[a,l]pyrene  (ISO)
Dibutyl phosphate  (ISO)
dibutyl phthalate  (ISO)
diclofenac  (ISO)
Dictamnine  (ISO)
diethyl phthalate  (ISO)
Diisodecyl phthalate  (ISO)
diisononyl phthalate  (ISO)
dioscin  (ISO)
dioxygen  (EXP)
disodium selenite  (ISO)
dorsomorphin  (ISO)
doxazosin  (ISO)
doxorubicin  (EXP,ISO)
emodin  (EXP)
endosulfan  (ISO)
ethanol  (ISO)
ethyl methanesulfonate  (ISO)
everolimus  (ISO)
fenthion  (ISO)
flavonoids  (EXP)
flavonol  (ISO)
flubendazole  (ISO)
flutamide  (EXP)
folic acid  (ISO)
formaldehyde  (ISO)
fulvestrant  (ISO)
gadolinium trichloride  (ISO)
gallic acid  (ISO)
Garcinol  (ISO)
geldanamycin  (ISO)
gemcitabine  (ISO)
genistein  (ISO)
Geraniin  (ISO)
glucose  (EXP,ISO)
halothane  (ISO)
heparin  (ISO)
hyaluronic acid  (EXP)
hydrogen peroxide  (EXP,ISO)
indometacin  (ISO)
irinotecan  (ISO)
isoflurane  (EXP)
ivermectin  (ISO)
ketamine  (EXP)
L-1,4-dithiothreitol  (ISO)
L-ascorbic acid  (EXP)
lead(0)  (EXP,ISO)
lipopolysaccharide  (ISO)
lithocholic acid  (ISO)
luteolin  (ISO)
LY294002  (ISO)
magnesium atom  (ISO)
mebendazole  (ISO)
methidathion  (ISO)
methyl methanesulfonate  (ISO)
methylisothiazolinone  (EXP)
methylmercury chloride  (ISO)
microcystin-LR  (EXP)
ML-7  (ISO)
morphine  (EXP)
N(4)-hydroxycytidine  (ISO)
N-acetyl-L-cysteine  (ISO)
nickel dichloride  (ISO)
nicotine  (ISO)
nitric oxide  (ISO)
ochratoxin A  (ISO)
Octicizer  (ISO)
okadaic acid  (ISO)
Ophiopogonin D  (ISO)
oxotremorine M  (ISO)
ozone  (EXP)
p-menthan-3-ol  (ISO)
p-tert-Amylphenol  (ISO)
paracetamol  (ISO)
pentachlorophenol  (ISO)
perfluorohexanesulfonic acid  (ISO)
perfluorooctane-1-sulfonic acid  (EXP,ISO)
phenethyl caffeate  (ISO)
phenylarsine oxide  (ISO)
phenylmercury acetate  (ISO)
phorbol 13-acetate 12-myristate  (ISO)
phosgene  (ISO)
picoxystrobin  (ISO)
pinosylvin  (ISO)
pirinixic acid  (ISO)
platycodin D  (ISO)
poly(vinylpyrrolidone)  (ISO)
potassium chromate  (ISO)
potassium iodide  (EXP)
progesterone  (EXP)
protein kinase inhibitor  (ISO)
quercetin  (ISO)
quercetin 3-O-beta-D-glucofuranoside  (ISO)
quercetin 3-O-beta-D-glucopyranoside  (ISO)
quinacrine  (ISO)
reactive oxygen species  (ISO)
resveratrol  (ISO)
rotenone  (ISO)
S-butyl-DL-homocysteine (S,R)-sulfoximine  (ISO)
Salinomycin  (ISO)
Salvianolic acid A  (ISO)
SB 431542  (ISO)
silver atom  (EXP)
silver(0)  (EXP)
simvastatin  (ISO)
sirolimus  (ISO)
sodium arsenite  (EXP,ISO)
sodium chloride  (ISO)
sulindac sulfide  (ISO)
tamoxifen  (ISO)
terbinafine  (ISO)
tert-butyl hydroperoxide  (ISO)
testosterone  (ISO)
tetrachloromethane  (ISO)
tetrathiomolybdate(2-)  (EXP)
thapsigargin  (ISO)
thimerosal  (ISO)
thiopental  (EXP)
titanium dioxide  (ISO)
trans-pinosylvin  (ISO)
trichostatin A  (ISO)
triphenyl phosphate  (ISO)
Triptolide  (EXP,ISO)
tropan-3alpha-yl 3-hydroxy-2-phenylpropanoate  (ISO)
Tryptanthrine  (ISO)
tyrphostin AG 1478  (ISO)
uranium atom  (ISO)
valproic acid  (ISO)
wortmannin  (EXP,ISO)
zearalenone  (EXP,ISO)
zoledronic acid  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
angiogenesis  (IEA,ISO)
axonogenesis  (ISO)
blood vessel development  (ISO)
cell migration  (ISO)
cellular response to morphine  (IEP)
cellular response to transforming growth factor beta stimulus  (ISO)
central nervous system neuron axonogenesis  (ISO)
endothelial cell migration  (ISO)
ephrin receptor signaling pathway  (ISO,ISS)
epidermal growth factor receptor signaling pathway  (IBA)
extracellular matrix organization  (ISO)
fat cell differentiation  (IEP)
growth hormone receptor signaling pathway  (ISO)
integrin-mediated signaling pathway  (ISO,ISS)
intracellular chloride ion homeostasis  (IMP)
JNK cascade  (IMP)
MAPK cascade  (IMP)
microtubule cytoskeleton organization  (ISO)
negative regulation of anoikis  (ISO)
negative regulation of apoptotic process  (IMP,ISO)
negative regulation of autophagy  (ISO)
negative regulation of axonogenesis  (ISO)
negative regulation of cell migration  (IMP)
negative regulation of cell-cell adhesion  (ISO)
negative regulation of organ growth  (ISO)
negative regulation of synapse assembly  (ISO)
neuron migration  (ISO)
nuclear migration  (ISO)
organ growth  (ISO)
peptidyl-tyrosine autophosphorylation  (ISO)
peptidyl-tyrosine phosphorylation  (ISO,ISS)
positive regulation of cardiac muscle hypertrophy  (ISO)
positive regulation of cell adhesion  (IMP)
positive regulation of cell growth  (IMP)
positive regulation of cell migration  (IBA,IMP,ISO)
positive regulation of cell population proliferation  (IEA,ISO,ISS)
positive regulation of epithelial cell migration  (ISO)
positive regulation of epithelial to mesenchymal transition  (ISO)
positive regulation of fibroblast migration  (ISO)
positive regulation of glial cell proliferation  (IMP)
positive regulation of macrophage chemotaxis  (ISO)
positive regulation of macrophage proliferation  (ISO)
positive regulation of phagocytosis  (IMP)
positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction  (ISO,ISS)
positive regulation of protein kinase activity  (ISO,ISS)
positive regulation of protein phosphorylation  (ISO,ISS)
positive regulation of smooth muscle cell migration  (IMP)
positive regulation of smooth muscle cell proliferation  (IMP)
positive regulation of synaptic transmission  (IMP)
positive regulation of ubiquitin-dependent protein catabolic process  (ISO,ISS)
positive regulation of wound healing  (ISO)
protein autophosphorylation  (ISO,ISS)
protein phosphorylation  (IEA)
regulation of biological quality  (IEA)
regulation of cell adhesion  (IBA)
regulation of cell adhesion mediated by integrin  (ISO,ISS)
regulation of cell population proliferation  (ISO,ISS)
regulation of cell shape  (ISO,ISS)
regulation of cellular component organization  (IEA)
regulation of epithelial cell migration  (ISO)
regulation of focal adhesion assembly  (ISO)
regulation of modification of postsynaptic actin cytoskeleton  (ISO)
regulation of multicellular organismal process  (IEA)
regulation of osteoblast differentiation  (ISO,ISS)
regulation of protein phosphorylation  (ISO)
regulation of substrate adhesion-dependent cell spreading  (ISO)
response to arsenic-containing substance  (IEP)
response to estradiol  (IEP)
response to glucose  (IEP)
response to mechanical stimulus  (IEP)
response to organic cyclic compound  (IEP)
response to xenobiotic stimulus  (IEP)
signal complex assembly  (IEA)
transforming growth factor beta receptor signaling pathway  (ISO)
vasculogenesis  (ISO)
vasodilation  (IMP)

Cellular Component

References

References - curated
# Reference Title Reference Citation
1. Extracellular signal-regulated kinase activation during renal ischemia/reperfusion mediates focal adhesion dissolution and renal injury. Alderliesten M, etal., Am J Pathol. 2007 Aug;171(2):452-62. Epub 2007 Jul 9.
2. A role for enhanced integrin and FAK expression in uremia-induced parathyroid hyperplasia. Arcidiacono MV, etal., J Nephrol. 2007 Mar-Apr;20(2):228-33.
3. Integrin dynamics produce a delayed stage of long-term potentiation and memory consolidation. Babayan AH, etal., J Neurosci. 2012 Sep 12;32(37):12854-61. doi: 10.1523/JNEUROSCI.2024-12.2012.
4. Focal adhesion kinase protein levels in gut epithelial motility. Basson MD, etal., Am J Physiol Gastrointest Liver Physiol. 2006 Sep;291(3):G491-9.
5. Focal adhesion kinase (FAK)-dependent regulation of S-phase kinase-associated protein-2 (Skp-2) stability. A novel mechanism regulating smooth muscle cell proliferation. Bond M, etal., J Biol Chem. 2004 Sep 3;279(36):37304-10. Epub 2004 Jun 18.
6. FAK dimerization controls its kinase-dependent functions at focal adhesions. Brami-Cherrier K, etal., EMBO J. 2014 Feb 18;33(4):356-70. doi: 10.1002/embj.201386399. Epub 2014 Jan 30.
7. Cloning of focal adhesion kinase, pp125FAK, from rat brain reveals multiple transcripts with different patterns of expression. Burgaya F and Girault JA, Brain Res Mol Brain Res 1996 Apr;37(1-2):63-73.
8. The effects of morphine treatment on the NCAM and its signaling in the MLDS of rats. Cao JP, etal., Drug Chem Toxicol. 2016 Oct;39(4):418-23. doi: 10.3109/01480545.2015.1137302. Epub 2016 Jan 28.
9. Integrin beta1 is involved in the signaling of glial cell line-derived neurotrophic factor. Cao JP, etal., J Comp Neurol. 2008 Jul 10;509(2):203-10.
10. Dystrophin Dp71f associates with the beta1-integrin adhesion complex to modulate PC12 cell adhesion. Cerna J, etal., J Mol Biol. 2006 Oct 6;362(5):954-65. Epub 2006 Aug 1.
11. Gonadotropin releasing hormone analogue therapy alters signal transduction pathways involving mitogen-activated protein and focal adhesion kinases in leiomyoma. Chegini N and Kornberg L, J Soc Gynecol Investig. 2003 Jan;10(1):21-6.
12. [Effects of prednisone on renal FAK and Pyk2 expressions in rats with adriamycin- induced nephritis]. Chen X, etal., Nan Fang Yi Ke Da Xue Xue Bao. 2014 Jul;34(8):1149-53.
13. Effects of dexmedetomidine on hippocampal focal adhesion kinase tyrosine phosphorylation in physiologic and ischemic conditions. Dahmani S, etal., Anesthesiology. 2005 Nov;103(5):969-77.
14. Thiopental and isoflurane attenuate the decrease in hippocampal phosphorylated Focal Adhesion Kinase (pp125FAK) content induced by oxygen-glucose deprivation. Dahmani S, etal., Br J Anaesth. 2004 Aug;93(2):270-4. Epub 2004 Jun 11.
15. Lidocaine increases phosphorylation of focal adhesion kinase in rat hippocampal slices. Dahmani S, etal., Eur J Pharmacol. 2004 Apr 5;489(1-2):55-8.
16. Focal adhesion kinase as a RhoA-activable signaling scaffold mediating Akt activation and cardiomyocyte protection. Del Re DP, etal., J Biol Chem. 2008 Dec 19;283(51):35622-9. Epub 2008 Oct 14.
17. Regulation of a neuronal form of focal adhesion kinase by anandamide. Derkinderen P, etal., Science 1996 Sep 20;273(5282):1719-22.
18. Focal adhesion kinase signaling promotes phagocytosis of integrin-bound photoreceptors. Finnemann SC EMBO J 2003 Aug 15;22(16):4143-54.
19. Fibre-type specific concentration of focal adhesion kinase at the sarcolemma: influence of fibre innervation and regeneration. Fluck M, etal., J Exp Biol. 2002 Aug;205(Pt 16):2337-48.
20. Weak expression of focal adhesion kinase (pp125FAK) in patients with cervical cancer is associated with poor disease outcome. Gabriel B, etal., Clin Cancer Res. 2006 Apr 15;12(8):2476-83.
21. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
22. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
23. Bit-1 mediates integrin-dependent cell survival through activation of the NFkappaB pathway. Griffiths GS, etal., J Biol Chem. 2011 Apr 22;286(16):14713-23. doi: 10.1074/jbc.M111.228387. Epub 2011 Mar 7.
24. Differential expression of protease activated receptor 1 (Par1) and pY397FAK in benign and malignant human ovarian tissue samples. Grisaru-Granovsky S, etal., Int J Cancer. 2005 Jan 20;113(3):372-8.
25. The role of PTPN13 in invasion and metastasis of lung squamous cell carcinoma. Han X, etal., Exp Mol Pathol. 2013 Dec;95(3):270-5. doi: 10.1016/j.yexmp.2013.07.008. Epub 2013 Jul 29.
26. Regional Regulation of Purkinje Cell Dendritic Spines by Integrins and Eph/Ephrins. Heintz TG, etal., PLoS One. 2016 Aug 12;11(8):e0158558. doi: 10.1371/journal.pone.0158558. eCollection 2016.
27. Vascular endothelial growth factor receptor-2: structure, function, intracellular signalling and therapeutic inhibition. Holmes K, etal., Cell Signal. 2007 Oct;19(10):2003-12. Epub 2007 Jun 12.
28. Relationship between focal adhesion kinase and hepatic stellate cell proliferation during rat hepatic fibrogenesis. Jiang HQ, etal., World J Gastroenterol. 2004 Oct 15;10(20):3001-5.
29. Overexpression of focal adhesion kinase, a protein tyrosine kinase, in ovarian carcinoma. Judson PL, etal., Cancer. 1999 Oct 15;86(8):1551-6.
30. The GIT family of proteins forms multimers and associates with the presynaptic cytomatrix protein Piccolo. Kim S, etal., J Biol Chem. 2003 Feb 21;278(8):6291-300. Epub 2002 Dec 6.
31. Interaction between liprin-alpha and GIT1 is required for AMPA receptor targeting. Ko J, etal., J Neurosci. 2003 Mar 1;23(5):1667-77.
32. Role of focal adhesion kinase in flow-induced dilation of coronary arterioles. Koshida R, etal., Arterioscler Thromb Vasc Biol. 2005 Dec;25(12):2548-53. Epub 2005 Sep 29.
33. Focal adhesion kinase is required for endothelin-induced cell cycle progression of cultured astrocytes. Koyama Y, etal., Glia. 2003 Aug;43(2):185-9.
34. High-density rat radiation hybrid maps containing over 24,000 SSLPs, genes, and ESTs provide a direct link to the rat genome sequence. Kwitek AE, etal., Genome Res. 2004 Apr;14(4):750-7
35. Mammary epithelial-specific disruption of the focal adhesion kinase blocks mammary tumor progression. Lahlou H, etal., Proc Natl Acad Sci U S A. 2007 Dec 18;104(51):20302-7. Epub 2007 Dec 3.
36. The effect of elevated extracellular glucose on adherens junction proteins in cultured rat heart endothelial cells. Lee HZ, etal., Life Sci. 2004 Mar 12;74(17):2085-96.
37. Cleavage of focal adhesion kinase (FAK) is essential in adipocyte differentiation. Li JJ and Xie D, Biochem Biophys Res Commun. 2007 Jun 8;357(3):648-54. Epub 2007 Apr 9.
38. NCAM signaling mediates the effects of GDNF on chronic morphine-induced neuroadaptations. Li L, etal., J Mol Neurosci. 2014 Aug;53(4):580-9. doi: 10.1007/s12031-013-0224-0. Epub 2014 Jan 8.
39. Zhonghua bing li xue za zhi Chinese journal of pathology Li ZY, etal., Zhonghua Bing Li Xue Za Zhi. 2007 Oct;36(10):677-80.
40. Upregulation of focal adhesion kinase (FAK) expression in ductal carcinoma in situ (DCIS) is an early event in breast tumorigenesis. Lightfoot HM Jr, etal., Breast Cancer Res Treat. 2004 Nov;88(2):109-16.
41. Expression of integrinalpha5beta1, focal adhesion kinase and integrin-linked kinase in rat condylar cartilage during mandibular lateral displacement. Liu C, etal., Arch Oral Biol. 2008 Mar 20;.
42. Focal adhesion kinase overexpression in endometrial neoplasia. Livasy CA, etal., Appl Immunohistochem Mol Morphol. 2004 Dec;12(4):342-5.
43. Increased tyrosine phosphorylation of platelet proteins including pp125(FAK) suggests endogenous activation and aggregation in pulmonary hypertension. Maeda NY, etal., Clin Appl Thromb Hemost. 2005 Oct;11(4):411-5.
44. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
45. Intrinsic focal adhesion kinase activity controls orthotopic breast carcinoma metastasis via the regulation of urokinase plasminogen activator expression in a syngeneic tumor model. Mitra SK, etal., Oncogene. 2006 Jul 27;25(32):4429-40. Epub 2006 Mar 20.
46. The expression and tyrosine phosphorylation of E-cadherin/catenin adhesion complex, and focal adhesion kinase in invasive cervical carcinomas. Moon HS, etal., Int J Gynecol Cancer. 2003 Sep-Oct;13(5):640-6.
47. Alteration of focal adhesion kinase expression in eutopic endometrium of women with endometriosis. Mu L, etal., Fertil Steril. 2008 Mar;89(3):529-37. Epub 2007 Jun 4.
48. High resolution genomic analysis of sporadic breast cancer using array-based comparative genomic hybridization. Naylor TL, etal., Breast Cancer Res. 2005;7(6):R1186-98. Epub 2005 Nov 24.
49. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
50. Marked suppression of tumor growth by FTY720 in a rat liver tumor model: the significance of down-regulation of cell survival Akt pathway. Ng KT, etal., Int J Oncol. 2007 Feb;30(2):375-80.
51. Expression of focal adhesion kinase in small-cell lung carcinoma. Ocak S, etal., Cancer. 2012 Mar 1;118(5):1293-301. doi: 10.1002/cncr.26382. Epub 2011 Jul 28.
52. DNA copy number aberrations in small-cell lung cancer reveal activation of the focal adhesion pathway. Ocak S, etal., Oncogene. 2010 Dec 2;29(48):6331-42. doi: 10.1038/onc.2010.362. Epub 2010 Aug 30.
53. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
54. FAK-related nonkinase attenuates hypertrophy induced by angiotensin-II in cultured neonatal rat cardiac myocytes. Qin J and Liu ZX, Acta Pharmacol Sin. 2006 Sep;27(9):1159-64.
55. Role of protein-tyrosine phosphatase SHP2 in focal adhesion kinase down-regulation during neutrophil cathepsin G-induced cardiomyocytes anoikis. Rafiq K, etal., J Biol Chem. 2006 Jul 14;281(28):19781-92. Epub 2006 May 11.
56. c-Cbl ubiquitin ligase regulates focal adhesion protein turnover and myofibril degeneration induced by neutrophil protease cathepsin G. Rafiq K, etal., J Biol Chem. 2012 Feb 17;287(8):5327-39. doi: 10.1074/jbc.M111.307009. Epub 2011 Dec 27.
57. Thy-1, via its GPI anchor, modulates Src family kinase and focal adhesion kinase phosphorylation and subcellular localization, and fibroblast migration, in response to thrombospondin-1/hep I. Rege TA, etal., Exp Cell Res. 2006 Nov 15;312(19):3752-67. Epub 2006 Sep 12.
58. GOA pipeline RGD automated data pipeline
59. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
60. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
61. Expression of focal adhesion kinase in normal and pathologic human prostate tissues. Rovin JD, etal., Prostate. 2002 Oct 1;53(2):124-32.
62. Multiple connections link FAK to cell motility and invasion. Schlaepfer DD and Mitra SK, Curr Opin Genet Dev. 2004 Feb;14(1):92-101.
63. Beta1-adrenergic receptors promote focal adhesion signaling downregulation and myocyte apoptosis in acute volume overload. Seqqat R, etal., J Mol Cell Cardiol. 2012 Aug;53(2):240-9. doi: 10.1016/j.yjmcc.2012.05.004. Epub 2012 May 15.
64. Focal adhesion kinase is a blood-testis barrier regulator. Siu ER, etal., Proc Natl Acad Sci U S A. 2009 Jun 9;106(23):9298-303. doi: 10.1073/pnas.0813113106. Epub 2009 May 21.
65. Focal adhesion kinase and paxillin: novel regulators of brain sexual differentiation? Speert DB, etal., Endocrinology. 2007 Jul;148(7):3391-401. Epub 2007 Apr 5.
66. Variations of proline-rich kinase Pyk2 expression correlate with prostate cancer progression. Stanzione R, etal., Lab Invest. 2001 Jan;81(1):51-9.
67. P-glycoprotein regulates blood-testis barrier dynamics via its effects on the occludin/zonula occludens 1 (ZO-1) protein complex mediated by focal adhesion kinase (FAK). Su L, etal., Proc Natl Acad Sci U S A. 2011 Dec 6;108(49):19623-8. doi: 10.1073/pnas.1111414108. Epub 2011 Nov 21.
68. Hypertension promotes phosphorylation of focal adhesion kinase and proline-rich tyrosine kinase 2 in rats: implication for the pathogenesis of hypertensive vascular disease. Sugimura K, etal., Tohoku J Exp Med. 2010 Nov;222(3):201-10.
69. An endogenous inhibitor of focal adhesion kinase blocks Rac1/JNK but not Ras/ERK-dependent signaling in vascular smooth muscle cells. Sundberg LJ, etal., J Biol Chem. 2003 Aug 8;278(32):29783-91. Epub 2003 Jun 2.
70. High glucose levels inhibit focal adhesion kinase-mediated wound healing of rat peritoneal mesothelial cells. Tamura M, etal., Kidney Int. 2003 Feb;63(2):722-31.
71. Activation of signaling molecules and matrix metalloproteinases in right ventricular myocardium of rats with pulmonary hypertension. Umar S, etal., Pathol Res Pract. 2007;203(12):863-72. Epub 2007 Oct 29.
72. Requirement for focal adhesion kinase in the early phase of mammary adenocarcinoma lung metastasis formation. van Nimwegen MJ, etal., Cancer Res. 2005 Jun 1;65(11):4698-706.
73. Focal adhesion kinase and protein kinase B cooperate to suppress doxorubicin-induced apoptosis of breast tumor cells. van Nimwegen MJ, etal., Mol Pharmacol. 2006 Oct;70(4):1330-9. Epub 2006 Jul 6.
74. Regulation of cardiac volume-sensitive chloride channel by focal adhesion kinase and Src kinase. Walsh KB and Zhang J, Am J Physiol Heart Circ Physiol. 2005 Dec;289(6):H2566-74. Epub 2005 Jul 22.
75. Specific induction of pp125 focal adhesion kinase in human breast cancer. Watermann DO, etal., Br J Cancer. 2005 Sep 19;93(6):694-8.
76. Sodium arsenite exposure alters cell migration, focal adhesion localization and decreases tyrosine phosphorylation of focal adhesion kinase in H9C2 myoblasts. Yancy SL, etal., Toxicol Sci. 2005 Apr;84(2):278-86. Epub 2004 Nov 10.
77. Focal adhesion kinase is required, but not sufficient, for the induction of long-term potentiation in dentate gyrus neurons in vivo. Yang YC, etal., J Neurosci. 2003 May 15;23(10):4072-80.
78. Nuclear compartmentalization of FAK and FRNK in cardiac myocytes. Yi XP, etal., Am J Physiol Heart Circ Physiol. 2006 Jun;290(6):H2509-15. Epub 2005 Dec 22.
79. Subcellular redistribution of focal adhesion kinase and its related nonkinase in hypertrophic myocardium. Yi XP, etal., Hypertension 2003 Jun;41(6):1317-23.
80. Activated focal adhesion kinase involved in adhesion and migration of vascular smooth muscle cells stimulated by fibronectin. Yin H, etal., Chin Med J (Engl). 2002 Apr;115(4):494-7.
Additional References at PubMed
PMID:2132399   PMID:7529876   PMID:7673154   PMID:8889548   PMID:9038154   PMID:10655584   PMID:10699171   PMID:10742111   PMID:10925297   PMID:11331870   PMID:11513739   PMID:11784865  
PMID:12133485   PMID:12235133   PMID:12391143   PMID:12556538   PMID:12595342   PMID:12651850   PMID:12829427   PMID:12932810   PMID:12941275   PMID:12967635   PMID:14551814   PMID:14642275  
PMID:14676198   PMID:14715243   PMID:14963000   PMID:15077193   PMID:15096502   PMID:15166238   PMID:15172101   PMID:15174102   PMID:15206825   PMID:15287896   PMID:15378065   PMID:15494733  
PMID:15576648   PMID:15591141   PMID:15640164   PMID:15681841   PMID:15728191   PMID:15855171   PMID:15914540   PMID:15923313   PMID:15967814   PMID:16010975   PMID:16095866   PMID:16298995  
PMID:16374517   PMID:16405917   PMID:16803572   PMID:16927379   PMID:17012369   PMID:17088251   PMID:17136425   PMID:17179255   PMID:17240116   PMID:17417603   PMID:17549512   PMID:17583725  
PMID:17868879   PMID:17877062   PMID:17986008   PMID:17999938   PMID:18206965   PMID:18297732   PMID:18539755   PMID:18662671   PMID:18757826   PMID:18773890   PMID:19016591   PMID:19116150  
PMID:19118217   PMID:19141060   PMID:19172391   PMID:19213829   PMID:19224536   PMID:19340459   PMID:19361463   PMID:19372463   PMID:19470773   PMID:19470782   PMID:19484266   PMID:19553453  
PMID:19793767   PMID:19880666   PMID:19912685   PMID:19913511   PMID:20142421   PMID:20705914   PMID:21180139   PMID:21246051   PMID:21412826   PMID:21562308   PMID:21569089   PMID:21660950  
PMID:21703394   PMID:21829547   PMID:21852560   PMID:21921830   PMID:21937583   PMID:22120166   PMID:22227249   PMID:22293597   PMID:22402981   PMID:22778269   PMID:22797892   PMID:22914642  
PMID:23073828   PMID:23168795   PMID:23301073   PMID:23463649   PMID:23574715   PMID:23755149   PMID:23880313   PMID:23904105   PMID:24036928   PMID:24056044   PMID:24169556   PMID:24703506  
PMID:24742749   PMID:24930861   PMID:25280940   PMID:25300309   PMID:25319025   PMID:25708150   PMID:25820249   PMID:25898827   PMID:26294392   PMID:26481700   PMID:26742689   PMID:26754294  
PMID:26763945   PMID:26835911   PMID:26846226   PMID:26884826   PMID:27212270   PMID:27427476   PMID:27428469   PMID:27704688   PMID:27827993   PMID:27994061   PMID:28360109   PMID:28445805  
PMID:28759036   PMID:28851074   PMID:30138615   PMID:30154481   PMID:30187999   PMID:31630787   PMID:32352989   PMID:32592615   PMID:32707896   PMID:33051346   PMID:33434537   PMID:33847460  
PMID:37607602  


Genomics

Comparative Map Data
Ptk2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr87107,015,730 - 107,220,865 (-)NCBIGRCr8
mRatBN7.27105,126,725 - 105,331,848 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl7105,126,728 - 105,331,783 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx7106,875,344 - 107,035,378 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.07109,096,927 - 109,256,959 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.07109,044,956 - 109,204,985 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.07114,436,419 - 114,611,317 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl7114,437,361 - 114,590,119 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.07114,371,979 - 114,525,553 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.47110,933,298 - 111,084,554 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.17110,967,527 - 111,118,784 (-)NCBI
Celera7101,534,957 - 101,690,471 (-)NCBICelera
RH 3.4 Map7725.6RGD
Cytogenetic Map7q34NCBI
PTK2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh388140,657,900 - 141,002,079 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl8140,657,900 - 141,002,216 (-)EnsemblGRCh38hg38GRCh38
GRCh378141,667,999 - 142,012,178 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 368141,737,683 - 142,080,514 (-)NCBINCBI36Build 36hg18NCBI36
Build 348141,737,682 - 142,080,514NCBI
Celera8137,836,859 - 138,179,410 (-)NCBICelera
Cytogenetic Map8q24.3NCBI
HuRef8136,979,065 - 137,322,195 (-)NCBIHuRef
CHM1_18141,708,729 - 142,051,666 (-)NCBICHM1_1
T2T-CHM13v2.08141,777,902 - 142,122,150 (-)NCBIT2T-CHM13v2.0
Ptk2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391573,076,951 - 73,297,192 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1573,076,951 - 73,295,129 (-)EnsemblGRCm39 Ensembl
GRCm381573,205,102 - 73,423,820 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1573,205,102 - 73,423,280 (-)EnsemblGRCm38mm10GRCm38
MGSCv371573,035,535 - 73,253,621 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361573,032,362 - 73,221,980 (-)NCBIMGSCv36mm8
Celera1574,705,367 - 74,923,905 (-)NCBICelera
Cytogenetic Map15D3NCBI
cM Map1533.94NCBI
Ptk2
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495546114,337,914 - 14,556,931 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495546114,337,914 - 14,622,779 (-)NCBIChiLan1.0ChiLan1.0
PTK2
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v27158,052,611 - 158,397,828 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan18133,583,257 - 133,928,558 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v08137,330,777 - 137,677,306 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.18140,412,773 - 140,743,129 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl8140,412,773 - 140,684,898 (-)Ensemblpanpan1.1panPan2
PTK2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11335,302,439 - 35,541,336 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1335,303,380 - 35,541,294 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1335,161,620 - 35,427,478 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01335,687,298 - 35,953,785 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1335,687,298 - 35,953,782 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11335,407,367 - 35,673,847 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01335,497,341 - 35,763,586 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01335,917,116 - 36,183,296 (-)NCBIUU_Cfam_GSD_1.0
Ptk2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_0244053032,953,767 - 3,152,431 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493647010,379,872 - 10,578,543 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_00493647010,379,855 - 10,578,531 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
PTK2
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl42,656,614 - 2,896,054 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.142,656,606 - 2,896,060 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
PTK2
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.18134,897,511 - 135,246,300 (-)NCBIChlSab1.1ChlSab1.1chlSab2
Vero_WHO_p1.0NW_0236660394,888,238 - 5,242,010 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Ptk2
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462473515,461,178 - 15,714,071 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462473515,356,911 - 15,713,219 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Ptk2
845 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:293
Count of miRNA genes:179
Interacting mature miRNAs:199
Transcripts:ENSRNOT00000011219
Prediction methods:Microtar, Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1300179Kidm5Kidney mass QTL 53.51kidney mass (VT:0002707)left kidney wet weight (CMO:0000083)743747012135012528Rat
1331728Bp214Blood pressure QTL 2142.825arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)780221299124373579Rat
1331731Bp216Blood pressure QTL 2162.851arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)7102297359133492884Rat
2298475Eau6Experimental allergic uveoretinitis QTL 60.0029uvea integrity trait (VT:0010551)experimental autoimmune uveitis score (CMO:0001504)784257275129257275Rat
71114Niddm14Non-insulin dependent diabetes mellitus QTL 144.5blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)784257275129257275Rat
1357336Gluco6Glucose level QTL 63.4blood glucose amount (VT:0000188)serum glucose level (CMO:0000543)794811326116294265Rat
1358361Sradr5Stress Responsive Adrenal Weight QTL 55.55adrenal gland mass (VT:0010420)both adrenal glands wet weight (CMO:0000164)743747012108555253Rat
1357338Stl17Serum triglyceride level QTL 173.23blood triglyceride amount (VT:0002644)serum triglyceride level (CMO:0000360)769736356112729554Rat
631687Hcas1Hepatocarcinoma susceptibility QTL 13.90.001liver integrity trait (VT:0010547)liver tumorous lesion volume to total liver volume ratio (CMO:0001082)791412594129807172Rat
70159Bp61Blood pressure QTL 610.0001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)7103146217116738842Rat
634331Pia17Pristane induced arthritis QTL 174.7joint integrity trait (VT:0010548)arthritic paw count (CMO:0001460)773829340130221005Rat
61397Bw17Body weight QTL 176.3body mass (VT:0001259)body weight (CMO:0000012)793595647106839474Rat
1358914Bp266Blood pressure QTL 266arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)783591953134666232Rat
631504Cm27Cardiac mass QTL 273.45heart left ventricle mass (VT:0007031)heart left ventricle wet weight (CMO:0000071)744421311118198041Rat
634322Bw12Body weight QTL 120body mass (VT:0001259)body weight (CMO:0000012)783153392128153392Rat
70173Niddm19Non-insulin dependent diabetes mellitus QTL 194.330.00005blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)764002457135012528Rat
1549899Stresp8Stress response QTL 84.370.0008stress-related behavior trait (VT:0010451)defensive burying duration (CMO:0001961)790482196135012528Rat
2317052Aia17Adjuvant induced arthritis QTL 172.13joint integrity trait (VT:0010548)left rear ankle joint diameter (CMO:0002149)781737938126737938Rat
631529Tls2T-lymphoma susceptibility QTL 200.001thymus integrity trait (VT:0010555)percentage of study population developing T-cell lymphomas during a period of time (CMO:0001911)780221299109401111Rat
731176Glom5Glomerulus QTL 52.50.0035kidney glomerulus morphology trait (VT:0005325)count of superficial glomeruli not directly contacting the kidney surface (CMO:0001002)796670164135012528Rat
7411607Foco15Food consumption QTL 150.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)775918751120918751Rat
1558655Swd4Spike wave discharge measurement QTL 43.680.0002brain electrophysiology trait (VT:0010557)brain spike-and-wave discharge severity grade (CMO:0001988)786983365131983365Rat
634336Anxrr17Anxiety related response QTL 173.66locomotor behavior trait (VT:0001392)number of entries into a discrete space in an experimental apparatus (CMO:0000960)7924703115097879Rat
1331768Kidm10Kidney mass QTL 104.62096kidney mass (VT:0002707)left kidney wet weight (CMO:0000083)780221299125221299Rat
61357Bp38Blood pressure QTL 381.60.052arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)741333674119109060Rat
2313102Bmd79Bone mineral density QTL 792.30.0001tibia mineral mass (VT:1000283)total volumetric bone mineral density (CMO:0001728)794811085116738842Rat
731174Uae23Urinary albumin excretion QTL 232.40.0042urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)7104603555135012528Rat
2316947Rf58Renal function QTL 587.8kidney glomerulus morphology trait (VT:0005325)index of glomerular damage (CMO:0001135)768938720113886318Rat
1298528Bp169Blood pressure QTL 1690.0001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)761074194106074194Rat
1331746Kidm9Kidney mass QTL 93.934kidney mass (VT:0002707)right kidney wet weight (CMO:0000082)780221299112308525Rat
7411654Foco25Food consumption QTL 259.30.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)775918751120918751Rat
2316955Stl24Serum triglyceride level QTL 247.1blood triglyceride amount (VT:0002644)plasma triglyceride level (CMO:0000548)768938720113886318Rat
2299163Iddm34Insulin dependent diabetes mellitus QTL 342.71blood glucose amount (VT:0000188)age at onset/diagnosis of type 1 diabetes mellitus (CMO:0001140)791281130135012528Rat
2316952Pur22Proteinuria QTL 225.2urine protein amount (VT:0005160)urine protein level (CMO:0000591)768938720113886318Rat
631540Bw9Body weight QTL 94.5body mass (VT:0001259)body weight (CMO:0000012)769736226117455174Rat
1358891Bp265Blood pressure QTL 2652.21arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)783591953134666232Rat

Markers in Region
RH139110  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.27105,165,886 - 105,166,016 (+)MAPPERmRatBN7.2
Rnor_6.07114,479,057 - 114,479,186NCBIRnor6.0
Rnor_5.07114,414,617 - 114,414,746UniSTSRnor5.0
RGSC_v3.47110,972,806 - 110,972,935UniSTSRGSC3.4
Celera7101,574,059 - 101,574,188UniSTS
RH 3.4 Map7722.7UniSTS
Cytogenetic Map7q34UniSTS
Ptk2  
Rat AssemblyChrPosition (strand)SourceJBrowse
RGSC_v3.47110,933,361 - 110,933,513UniSTSRGSC3.4
RGSC_v3.47110,933,379 - 110,933,531UniSTSRGSC3.4
Celera7101,535,033 - 101,535,185UniSTS
Celera7101,535,051 - 101,535,203UniSTS
RH128225  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.27105,126,949 - 105,127,162 (+)MAPPERmRatBN7.2
Rnor_6.07114,436,644 - 114,436,856NCBIRnor6.0
Rnor_5.07114,372,204 - 114,372,416UniSTSRnor5.0
RGSC_v3.47110,933,510 - 110,933,722UniSTSRGSC3.4
Celera7101,535,182 - 101,535,394UniSTS
RH 3.4 Map7721.9UniSTS
Cytogenetic Map7q34UniSTS
RH130965  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.27105,127,140 - 105,127,327 (+)MAPPERmRatBN7.2
Rnor_6.07114,436,835 - 114,437,021NCBIRnor6.0
Rnor_5.07114,372,395 - 114,372,581UniSTSRnor5.0
RGSC_v3.47110,933,701 - 110,933,887UniSTSRGSC3.4
Celera7101,535,373 - 101,535,559UniSTS
RH 3.4 Map7722.6UniSTS
Cytogenetic Map7q34UniSTS
RH94436  
Rat AssemblyChrPosition (strand)SourceJBrowse
RH 3.4 Map7725.6UniSTS
Cytogenetic Map7q34UniSTS
RH138184  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.27105,230,462 - 105,230,635 (+)MAPPERmRatBN7.2
Rnor_6.07114,543,607 - 114,543,779NCBIRnor6.0
Rnor_5.07114,478,952 - 114,479,124UniSTSRnor5.0
RGSC_v3.47111,037,952 - 111,038,124UniSTSRGSC3.4
Celera7101,638,612 - 101,638,784UniSTS
RH 3.4 Map7722.8UniSTS
Cytogenetic Map7q34UniSTS
UniSTS:143067  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.27105,126,912 - 105,127,571 (+)MAPPERmRatBN7.2
Rnor_6.07114,436,607 - 114,437,265NCBIRnor6.0
Rnor_5.07114,372,167 - 114,372,825UniSTSRnor5.0
RGSC_v3.47110,933,473 - 110,934,131UniSTSRGSC3.4
Celera7101,535,145 - 101,535,803UniSTS
Cytogenetic Map7q34UniSTS
PMC84535P1  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.27105,161,304 - 105,162,290 (+)MAPPERmRatBN7.2
Rnor_6.07114,474,476 - 114,475,460NCBIRnor6.0
Rnor_5.07114,410,036 - 114,411,020UniSTSRnor5.0
RGSC_v3.47110,968,225 - 110,969,209UniSTSRGSC3.4
Celera7101,569,478 - 101,570,462UniSTS
Cytogenetic Map7q34UniSTS
PMC84535P3  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.27105,161,342 - 105,162,120 (+)MAPPERmRatBN7.2
Rnor_6.07114,474,514 - 114,475,290NCBIRnor6.0
Rnor_5.07114,410,074 - 114,410,850UniSTSRnor5.0
RGSC_v3.47110,968,263 - 110,969,039UniSTSRGSC3.4
Celera7101,569,516 - 101,570,292UniSTS
Cytogenetic Map7q34UniSTS
Ptk2  
Rat AssemblyChrPosition (strand)SourceJBrowse
Rnor_5.07114,372,073 - 114,372,225UniSTSRnor5.0
RGSC_v3.47110,933,379 - 110,933,531UniSTSRGSC3.4
Celera7101,535,051 - 101,535,203UniSTS
Cytogenetic Map7q34UniSTS
Ptk2  
Rat AssemblyChrPosition (strand)SourceJBrowse
Rnor_5.07114,372,055 - 114,372,207UniSTSRnor5.0
RGSC_v3.47110,933,361 - 110,933,513UniSTSRGSC3.4
Celera7101,535,033 - 101,535,185UniSTS
Cytogenetic Map7q34UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
nervous system
renal system
reproductive system
respiratory system
9 11 49 113 91 90 59 25 59 6 218 97 93 45 60 31

Sequence

Nucleotide Sequences
RefSeq Transcripts NM_013081 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017594678 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039078475 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039078477 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039078480 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063263043 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063263044 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063263045 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063263046 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063263047 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063263048 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063263049 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063263050 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063263051 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063263052 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063263054 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063263055 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063263056 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063263057 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063263058 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063263059 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XR_005486550 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XR_010052943 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AF020777 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AF020779 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AI717382 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CA508631 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CA511845 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CB713440 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH473950 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  EV773243 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JAXUCZ010000007 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  U43940 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  U43941 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  U43942 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Ensembl Acc Id: ENSRNOT00000011219   ⟹   ENSRNOP00000011219
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl7105,126,956 - 105,331,763 (-)Ensembl
Rnor_6.0 Ensembl7114,437,361 - 114,573,900 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000079599   ⟹   ENSRNOP00000075518
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl7105,126,728 - 105,283,089 (-)Ensembl
Rnor_6.0 Ensembl7114,440,949 - 114,590,119 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000095017   ⟹   ENSRNOP00000085395
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl7105,126,728 - 105,283,089 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000101944   ⟹   ENSRNOP00000089674
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl7105,126,956 - 105,331,763 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000109226   ⟹   ENSRNOP00000080431
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl7105,126,956 - 105,331,763 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000110466   ⟹   ENSRNOP00000093819
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl7105,243,450 - 105,331,783 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000112145   ⟹   ENSRNOP00000095122
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl7105,126,728 - 105,283,089 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000113790   ⟹   ENSRNOP00000092163
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl7105,126,956 - 105,331,763 (-)Ensembl
RefSeq Acc Id: NM_013081   ⟹   NP_037213
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr87107,015,730 - 107,172,091 (-)NCBI
mRatBN7.27105,126,725 - 105,283,089 (-)NCBI
Rnor_6.07114,436,419 - 114,590,208 (-)NCBI
Rnor_5.07114,371,979 - 114,525,553 (-)NCBI
RGSC_v3.47110,933,298 - 111,084,554 (-)RGD
Celera7101,534,957 - 101,690,471 (-)NCBI
Sequence:
RefSeq Acc Id: XM_039078475   ⟹   XP_038934403
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr87107,015,959 - 107,172,005 (-)NCBI
mRatBN7.27105,126,725 - 105,283,003 (-)NCBI
RefSeq Acc Id: XM_039078477   ⟹   XP_038934405
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr87107,015,959 - 107,172,005 (-)NCBI
mRatBN7.27105,126,725 - 105,283,003 (-)NCBI
RefSeq Acc Id: XM_039078480   ⟹   XP_038934408
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr87107,015,959 - 107,172,005 (-)NCBI
mRatBN7.27105,126,725 - 105,283,003 (-)NCBI
RefSeq Acc Id: XM_063263043   ⟹   XP_063119113
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr87107,015,959 - 107,220,862 (-)NCBI
RefSeq Acc Id: XM_063263044   ⟹   XP_063119114
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr87107,015,959 - 107,220,586 (-)NCBI
RefSeq Acc Id: XM_063263045   ⟹   XP_063119115
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr87107,015,959 - 107,220,862 (-)NCBI
RefSeq Acc Id: XM_063263046   ⟹   XP_063119116
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr87107,015,959 - 107,220,586 (-)NCBI
RefSeq Acc Id: XM_063263047   ⟹   XP_063119117
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr87107,015,959 - 107,220,862 (-)NCBI
RefSeq Acc Id: XM_063263048   ⟹   XP_063119118
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr87107,015,959 - 107,220,862 (-)NCBI
RefSeq Acc Id: XM_063263049   ⟹   XP_063119119
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr87107,015,959 - 107,220,857 (-)NCBI
RefSeq Acc Id: XM_063263050   ⟹   XP_063119120
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr87107,015,959 - 107,220,862 (-)NCBI
RefSeq Acc Id: XM_063263051   ⟹   XP_063119121
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr87107,015,959 - 107,220,862 (-)NCBI
RefSeq Acc Id: XM_063263052   ⟹   XP_063119122
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr87107,015,959 - 107,220,856 (-)NCBI
RefSeq Acc Id: XM_063263054   ⟹   XP_063119124
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr87107,015,959 - 107,220,855 (-)NCBI
RefSeq Acc Id: XM_063263055   ⟹   XP_063119125
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr87107,033,181 - 107,220,862 (-)NCBI
RefSeq Acc Id: XM_063263056   ⟹   XP_063119126
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr87107,044,587 - 107,172,005 (-)NCBI
RefSeq Acc Id: XM_063263057   ⟹   XP_063119127
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr87107,015,959 - 107,089,135 (-)NCBI
RefSeq Acc Id: XM_063263058   ⟹   XP_063119128
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr87107,015,959 - 107,063,664 (-)NCBI
RefSeq Acc Id: XM_063263059   ⟹   XP_063119129
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr87107,015,959 - 107,050,982 (-)NCBI
RefSeq Acc Id: XR_005486550
Type: NON-CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr87107,050,015 - 107,220,865 (-)NCBI
mRatBN7.27105,161,026 - 105,331,809 (-)NCBI
RefSeq Acc Id: XR_010052943
Type: NON-CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr87107,044,517 - 107,220,865 (-)NCBI
Protein Sequences
Protein RefSeqs NP_037213 (Get FASTA)   NCBI Sequence Viewer  
  XP_038934403 (Get FASTA)   NCBI Sequence Viewer  
  XP_038934405 (Get FASTA)   NCBI Sequence Viewer  
  XP_038934408 (Get FASTA)   NCBI Sequence Viewer  
  XP_063119113 (Get FASTA)   NCBI Sequence Viewer  
  XP_063119114 (Get FASTA)   NCBI Sequence Viewer  
  XP_063119115 (Get FASTA)   NCBI Sequence Viewer  
  XP_063119116 (Get FASTA)   NCBI Sequence Viewer  
  XP_063119117 (Get FASTA)   NCBI Sequence Viewer  
  XP_063119118 (Get FASTA)   NCBI Sequence Viewer  
  XP_063119119 (Get FASTA)   NCBI Sequence Viewer  
  XP_063119120 (Get FASTA)   NCBI Sequence Viewer  
  XP_063119121 (Get FASTA)   NCBI Sequence Viewer  
  XP_063119122 (Get FASTA)   NCBI Sequence Viewer  
  XP_063119124 (Get FASTA)   NCBI Sequence Viewer  
  XP_063119125 (Get FASTA)   NCBI Sequence Viewer  
  XP_063119126 (Get FASTA)   NCBI Sequence Viewer  
  XP_063119127 (Get FASTA)   NCBI Sequence Viewer  
  XP_063119128 (Get FASTA)   NCBI Sequence Viewer  
  XP_063119129 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAA86278 (Get FASTA)   NCBI Sequence Viewer  
  AAA86279 (Get FASTA)   NCBI Sequence Viewer  
  AAA86280 (Get FASTA)   NCBI Sequence Viewer  
  AAB72203 (Get FASTA)   NCBI Sequence Viewer  
  EDM16117 (Get FASTA)   NCBI Sequence Viewer  
  EDM16118 (Get FASTA)   NCBI Sequence Viewer  
  EDM16119 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000011219.7
  ENSRNOP00000075518.2
  ENSRNOP00000080431.1
  ENSRNOP00000085395.1
  ENSRNOP00000089674.1
  ENSRNOP00000092163.1
  ENSRNOP00000093819.1
  ENSRNOP00000095122.1
GenBank Protein O35346 (Get FASTA)   NCBI Sequence Viewer  
RefSeq Acc Id: NP_037213   ⟸   NM_013081
- UniProtKB: Q62900 (UniProtKB/Swiss-Prot),   O35346 (UniProtKB/Swiss-Prot),   A0A8L2Q4U8 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000075518   ⟸   ENSRNOT00000079599
Ensembl Acc Id: ENSRNOP00000011219   ⟸   ENSRNOT00000011219
RefSeq Acc Id: XP_038934408   ⟸   XM_039078480
- Peptide Label: isoform X4
- UniProtKB: A0A8I6A3T3 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038934405   ⟸   XM_039078477
- Peptide Label: isoform X3
- UniProtKB: A0A8I6A3T3 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038934403   ⟸   XM_039078475
- Peptide Label: isoform X2
- UniProtKB: A0A8I6A3T3 (UniProtKB/TrEMBL)
Ensembl Acc Id: ENSRNOP00000089674   ⟸   ENSRNOT00000101944
Ensembl Acc Id: ENSRNOP00000095122   ⟸   ENSRNOT00000112145
Ensembl Acc Id: ENSRNOP00000080431   ⟸   ENSRNOT00000109226
Ensembl Acc Id: ENSRNOP00000085395   ⟸   ENSRNOT00000095017
Ensembl Acc Id: ENSRNOP00000093819   ⟸   ENSRNOT00000110466
Ensembl Acc Id: ENSRNOP00000092163   ⟸   ENSRNOT00000113790
RefSeq Acc Id: XP_063119115   ⟸   XM_063263045
- Peptide Label: isoform X5
- UniProtKB: A0A8L2Q4U8 (UniProtKB/TrEMBL),   A0A8I6A8P2 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063119121   ⟸   XM_063263051
- Peptide Label: isoform X7
- UniProtKB: A0A8I6A3T3 (UniProtKB/TrEMBL),   A0A8I6AMW1 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063119120   ⟸   XM_063263050
- Peptide Label: isoform X6
- UniProtKB: A0A8I6A3T3 (UniProtKB/TrEMBL),   A0A0G2KAT5 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063119113   ⟸   XM_063263043
- Peptide Label: isoform X1
- UniProtKB: A0A8I6A3T3 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063119117   ⟸   XM_063263047
- Peptide Label: isoform X5
- UniProtKB: A0A8L2Q4U8 (UniProtKB/TrEMBL),   A0A8I6A8P2 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063119118   ⟸   XM_063263048
- Peptide Label: isoform X5
- UniProtKB: A0A8L2Q4U8 (UniProtKB/TrEMBL),   A0A8I6A8P2 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063119119   ⟸   XM_063263049
- Peptide Label: isoform X5
- UniProtKB: A0A8L2Q4U8 (UniProtKB/TrEMBL),   A0A8I6A8P2 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063119122   ⟸   XM_063263052
- Peptide Label: isoform X8
- UniProtKB: A0A8L2Q4U8 (UniProtKB/TrEMBL),   A0A8I6AH25 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063119124   ⟸   XM_063263054
- Peptide Label: isoform X9
- UniProtKB: A0A8L2Q4U8 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063119116   ⟸   XM_063263046
- Peptide Label: isoform X5
- UniProtKB: A0A8L2Q4U8 (UniProtKB/TrEMBL),   A0A8I6A8P2 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063119114   ⟸   XM_063263044
- Peptide Label: isoform X1
- UniProtKB: A0A8I6A3T3 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063119127   ⟸   XM_063263057
- Peptide Label: isoform X12
RefSeq Acc Id: XP_063119128   ⟸   XM_063263058
- Peptide Label: isoform X13
RefSeq Acc Id: XP_063119129   ⟸   XM_063263059
- Peptide Label: isoform X13
RefSeq Acc Id: XP_063119125   ⟸   XM_063263055
- Peptide Label: isoform X10
- UniProtKB: A6HRV3 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063119126   ⟸   XM_063263056
- Peptide Label: isoform X11
Protein Domains
FERM   Protein kinase

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-O35346-F1-model_v2 AlphaFold O35346 1-1055 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:3443 AgrOrtholog
BioCyc Gene G2FUF-33063 BioCyc
Ensembl Genes ENSRNOG00000007916 Ensembl, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000011219.7 UniProtKB/TrEMBL
  ENSRNOT00000079599.2 UniProtKB/TrEMBL
  ENSRNOT00000095017.1 UniProtKB/TrEMBL
  ENSRNOT00000101944.1 UniProtKB/TrEMBL
  ENSRNOT00000109226.1 UniProtKB/TrEMBL
  ENSRNOT00000110466.1 UniProtKB/TrEMBL
  ENSRNOT00000112145.1 UniProtKB/TrEMBL
  ENSRNOT00000113790.1 UniProtKB/TrEMBL
Gene3D-CATH 1.20.80.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  2.30.29.30 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Nucleotidyltransferases domain 2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Single helix bin UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Transferase(Phosphotransferase) domain 1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro Band_41_domain UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  FADK_N UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  FAK1-like_FERM_C UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  FAK1/PYK2_FERM_C UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  FERM/acyl-CoA-bd_prot_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  FERM_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  FERM_central UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  FERM_domain UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Focal_adhe_kin_target_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Focal_adhesion_kin_target_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Kinase-like_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PH-like_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Prot_kinase_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Protein_kinase_ATP_BS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Ser-Thr/Tyr_kinase_cat_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Tyr_kinase_AS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Tyr_kinase_cat_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Ubiquitin-like_domsf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:25614 UniProtKB/Swiss-Prot
NCBI Gene 25614 ENTREZGENE
PANTHER FERM AND PDZ DOMAIN-CONTAINING PROTEIN FAMILY MEMBER UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  NON-SPECIFIC PROTEIN-TYROSINE KINASE UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam FERM_C_FAK1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  FERM_M UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  FERM_N_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Focal_AT UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Pkinase_Tyr UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Ptk2 PhenoGen
PRINTS TYRKINASE UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE FERM_2 UniProtKB/Swiss-Prot
  FERM_3 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PROTEIN_KINASE_ATP UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PROTEIN_KINASE_DOM UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PROTEIN_KINASE_TYR UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
RatGTEx ENSRNOG00000007916 RatGTEx
SMART B41 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  TyrKc UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP PH domain-like UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SSF47031 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SSF54236 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SSF56112 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SSF68993 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A0A0G2KAT5 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I5ZQM0_RAT UniProtKB/TrEMBL
  A0A8I6A3T3 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I6A8P2 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I6AH25 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I6AJL3_RAT UniProtKB/TrEMBL
  A0A8I6AMW1 ENTREZGENE, UniProtKB/TrEMBL
  A0A8L2Q4U8 ENTREZGENE, UniProtKB/TrEMBL
  A6HRV3 ENTREZGENE, UniProtKB/TrEMBL
  A6HRV4_RAT UniProtKB/TrEMBL
  A6HRV5_RAT UniProtKB/TrEMBL
  FAK1_RAT UniProtKB/Swiss-Prot, ENTREZGENE
  Q62900 ENTREZGENE
UniProt Secondary Q62900 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2013-02-28 Ptk2  protein tyrosine kinase 2  Ptk2  PTK2 protein tyrosine kinase 2  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2004-09-10 Ptk2  PTK2 protein tyrosine kinase 2    protein tyrosine kinase 2  Name updated 1299863 APPROVED
2002-06-10 Ptk2  Protein tyrosine kinase      Symbol and Name status set to approved 70586 APPROVED