Ptgs1 (prostaglandin-endoperoxide synthase 1) - Rat Genome Database

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Gene: Ptgs1 (prostaglandin-endoperoxide synthase 1) Rattus norvegicus
Symbol: Ptgs1
Name: prostaglandin-endoperoxide synthase 1
RGD ID: 3439
Description: Predicted to enable oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen and prostaglandin-endoperoxide synthase activity. Involved in several processes, including learning or memory; negative regulation of catecholamine secretion; and response to corticosterone. Located in nuclear envelope. Used to study Alzheimer's disease; hepatic encephalopathy; renovascular hypertension; and ulcerative colitis. Biomarker of esophagus adenocarcinoma; glioblastoma; gliosarcoma; polycystic kidney disease; and renal cell carcinoma. Orthologous to human PTGS1 (prostaglandin-endoperoxide synthase 1); PARTICIPATES IN acetylsalicylic acid pharmacodynamics pathway; antipyrine drug pathway; arachidonic acid metabolic pathway; INTERACTS WITH 1,2-dimethylhydrazine; 1-naphthyl isothiocyanate; 17alpha-ethynylestradiol.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: COX-1; Cox-3; Cox1; Cox3; cyclooxygenase 1; cyclooxygenase 3; cyclooxygenase-1; PGH synthase 1; PGHS-1; PHS 1; prostaglandin G/H synthase 1; prostaglandin G/H synthase and cyclooxygenase; prostaglandin H2 synthase 1; prostaglandin-endoperoxide synthase 1 (prostaglandin G/H synthase and cyclooxygenase)
RGD Orthologs
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Candidate Gene For: Cia11 Bp52 Cm25
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Rat AssemblyChrPosition (strand)SourceGenome Browsers
GRCr8339,981,419 - 40,002,993 (+)NCBIGRCr8
mRatBN7.2319,584,015 - 19,605,589 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl319,584,015 - 19,605,586 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx322,661,928 - 22,683,470 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0331,246,853 - 31,268,395 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0329,494,672 - 29,516,226 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0315,560,685 - 15,582,339 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl315,560,712 - 15,582,344 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0320,869,915 - 20,891,512 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4315,343,832 - 15,365,412 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1315,240,203 - 15,261,784 (+)NCBI
Celera314,295,836 - 14,317,392 (+)NCBICelera
Cytogenetic Map3p11NCBI
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-alpha-viniferin  (ISO)
(+)-catechin  (ISO)
(+)-epicatechin-3-O-gallate  (ISO)
(-)-epigallocatechin 3-gallate  (ISO)
(R)-amygdalin  (ISO)
(S)-naringenin  (ISO)
1,2-dimethylhydrazine  (EXP,ISO)
1,4-phenylenediamine  (ISO)
1-naphthyl isothiocyanate  (EXP)
1-O-palmitoyl-2-O-(5-oxovaleryl)-sn-glycero-3-phosphocholine  (ISO)
12-HHTrE  (ISO)
15-deoxy-Delta(12,14)-prostaglandin J2  (ISO)
17alpha-ethynylestradiol  (EXP,ISO)
17beta-estradiol  (ISO)
2,2',4,4'-Tetrabromodiphenyl ether  (EXP,ISO)
2,2',5,5'-tetrachlorobiphenyl  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,4,6-trinitrobenzenesulfonic acid  (EXP)
2,4-dibromophenyl 2,4,5-tribromophenyl ether  (ISO)
2,6-di-tert-butyl-4-methylphenol  (ISO)
2-[4-[3-[2-(trifluoromethyl)-9-thioxanthenylidene]propyl]-1-piperazinyl]ethanol  (ISO)
2-acetyl-1-alkyl-sn-glycero-3-phosphocholine  (ISO)
2-amino-2-deoxy-D-galactopyranose  (ISO)
2-arachidonoylglycerol  (EXP)
24,25-Dihydroxyvitamin D  (EXP)
3,4-Methylenedioxyamphetamine  (ISO)
3-chloropropane-1,2-diol  (EXP)
3-isobutyl-1-methyl-7H-xanthine  (ISO)
3-methyl-3H-imidazo[4,5-f]quinolin-2-amine  (ISO)
3-methylcholanthrene  (ISO)
4,4'-methylene-bis-(2-chloroaniline)  (ISO)
4,4'-sulfonyldiphenol  (ISO)
4-hydroxyphenyl retinamide  (EXP,ISO)
5-aza-2'-deoxycytidine  (ISO)
8-Br-cAMP  (ISO)
8-hydroxy-2'-deoxyguanosine  (ISO)
9-cis-retinoic acid  (ISO)
acetaldehyde  (ISO)
acetamide  (EXP)
acetylsalicylic acid  (EXP,ISO)
acrolein  (ISO)
acrylamide  (EXP)
aflatoxin B1  (EXP)
Aflatoxin B2 alpha  (ISO)
aldehydo-D-glucose  (EXP,ISO)
aliskiren  (EXP)
all-trans-4-oxoretinoic acid  (ISO)
all-trans-retinoic acid  (ISO)
allethrin  (EXP)
alpha-pinene  (ISO)
aluminium atom  (ISO)
aluminium(0)  (ISO)
aminophenazone  (ISO)
ammonium chloride  (EXP)
amphibole asbestos  (ISO)
antipyrine  (ISO)
antirheumatic drug  (ISO)
apocynin  (EXP)
arachidonic acid  (ISO)
aristolochic acid A  (EXP,ISO)
arsenous acid  (ISO)
astemizole  (EXP)
atrazine  (ISO)
benzidine  (ISO)
benzo[a]pyrene  (ISO)
Benzo[a]pyrene-7,8-diol  (ISO)
benzo[b]fluoranthene  (ISO)
benzo[e]pyrene  (ISO)
Benzoylpaeoniflorin  (ISO)
biphenyl-4-amine  (ISO)
bis(2-chloroethyl) sulfide  (ISO)
bis(2-ethylhexyl) phthalate  (ISO)
bisphenol A  (EXP,ISO)
bisphenol F  (ISO)
budesonide  (EXP)
bumetanide  (ISO)
bupivacaine  (ISO)
buta-1,3-diene  (ISO)
butyric acid  (ISO)
cadmium atom  (ISO)
cadmium dichloride  (EXP,ISO)
cadmium sulfide  (ISO)
calciol  (ISO)
calcitriol  (EXP,ISO)
calcium atom  (EXP)
calcium(0)  (EXP)
carbon nanotube  (ISO)
carvedilol  (EXP)
celastrol  (ISO)
celecoxib  (EXP,ISO)
cisplatin  (ISO)
cobalt dichloride  (ISO)
copper atom  (EXP)
copper(0)  (EXP)
corticosterone  (EXP)
creatinine  (EXP)
curcumin  (ISO)
cyclophosphamide  (ISO)
cyfluthrin  (ISO)
cyhalothrin  (EXP)
cypermethrin  (EXP)
D-glucose  (EXP,ISO)
D-penicillamine  (ISO)
dexamethasone  (EXP,ISO)
diarsenic trioxide  (ISO)
diclofenac  (EXP,ISO)
dimethyl sulfoxide  (ISO)
dimethylarsinous acid  (ISO)
dioxygen  (ISO)
docebenone  (ISO)
donepezil hydrochloride  (ISO)
dorsomorphin  (ISO)
doxorubicin  (EXP,ISO)
DuP 697  (ISO)
enalapril  (ISO)
endosulfan  (EXP)
enniatin  (ISO)
entinostat  (ISO)
ethanol  (ISO)
etodolac  (ISO)
famotidine  (EXP)
fenofibrate  (EXP)
fenvalerate  (EXP)
ferulic acid  (ISO)
fipronil  (EXP)
flavonoids  (EXP)
flunixin  (EXP)
fluoxetine  (EXP)
flupenthixol  (ISO)
flurbiprofen  (EXP,ISO)
flutamide  (EXP)
formaldehyde  (EXP)
furan  (EXP)
furosemide  (EXP)
geldanamycin  (ISO)
gemcitabine  (ISO)
genistein  (ISO)
gentamycin  (EXP)
glucose  (EXP,ISO)
glycine betaine  (EXP)
glyphosate  (EXP)
histamine  (EXP)
hydrogen chloride  (ISO)
hydrogen peroxide  (EXP)
ibuprofen  (EXP,ISO)
indometacin  (EXP,ISO)
isoliquiritigenin  (ISO)
isoprenaline  (ISO)
isotretinoin  (ISO)
ivermectin  (ISO)
ketorolac  (ISO)
L-ascorbic acid  (EXP)
leukotriene C4  (ISO)
leukotriene D4  (ISO)
leukotriene E4  (ISO)
lipopolysaccharide  (EXP,ISO)
lipoteichoic acid  (EXP)
lornoxicam  (ISO)
lutein  (ISO)
lysophosphatidylcholine  (EXP)
Malabaricone C  (ISO)
MeIQx  (ISO)
meloxicam  (EXP)
mercury dibromide  (ISO)
metamizole sodium  (ISO)
methamphetamine  (ISO)
methapyrilene  (ISO)
methoxychlor  (EXP)
methylmercury chloride  (ISO)
miconazole  (EXP)
mifepristone  (EXP,ISO)
minocycline  (EXP)
Mitragynine  (ISO)
Mofezolac (TN)  (EXP,ISO)
mono(2-ethylhexyl) phthalate  (ISO)
morphine  (EXP)
N,N-diethyl-m-toluamide  (EXP)
N-nitrosodiethylamine  (EXP)
N-nitrosodimethylamine  (EXP)
nabumetone  (EXP)
naproxen  (EXP,ISO)
nickel dichloride  (ISO)
nickel subsulfide  (EXP)
nicotinic acid  (EXP,ISO)
nimesulide  (ISO)
nitric oxide  (EXP)
nitrofen  (EXP)
NS-398  (EXP,ISO)
ozone  (ISO)
p-chloromercuribenzoic acid  (ISO)
paeoniflorin  (ISO)
panobinostat  (ISO)
paracetamol  (EXP,ISO)
paraquat  (ISO)
paricalcitol  (ISO)
patchouli alcohol  (EXP)
Pentagastrin  (EXP)
perfluorooctanoic acid  (EXP)
permethrin  (EXP)
phenacetin  (ISO)
phenobarbital  (ISO)
phenylephrine  (ISO)
phenylmercury acetate  (ISO)
phorbol 13-acetate 12-myristate  (ISO)
phosgene  (ISO)
phosphorus atom  (ISO)
phosphorus(.)  (ISO)
pirinixic acid  (EXP,ISO)
piroxicam  (EXP)
potassium dichromate  (ISO)
progesterone  (EXP,ISO)
prostaglandin E2  (EXP,ISO)
pyrazines  (ISO)
pyrethrins  (EXP)
Pyridostigmine bromide  (EXP)
quartz  (ISO)
quercetin  (EXP,ISO)
Rebamipide  (EXP)
resveratrol  (EXP,ISO)
rivastigmine  (ISO)
rofecoxib  (ISO)
romidepsin  (ISO)
rotenone  (EXP)
S-adenosyl-L-methioninate  (ISO)
S-adenosyl-L-methionine  (ISO)
SB 431542  (ISO)
SC-58125  (ISO)
silicon dioxide  (ISO)
sodium arsenite  (EXP,ISO)
sodium chloride  (EXP)
sodium dichromate  (EXP,ISO)
sodium fluoride  (EXP,ISO)
sodium hydrogensulfite  (EXP)
sodium sulfite  (EXP)
streptozocin  (EXP)
succimer  (ISO)
sulforaphane  (ISO)
sulindac  (EXP)
sulindac sulfide  (ISO)
sulindac sulfone  (EXP)
Sulpyrine  (ISO)
tert-butyl hydroperoxide  (EXP)
testosterone  (EXP)
tetrachloromethane  (EXP,ISO)
thioacetamide  (EXP)
thiostrepton  (ISO)
thromboxane A2  (ISO)
thromboxane B2  (ISO)
thymoquinone  (ISO)
titanium dioxide  (ISO)
trans-piceid  (ISO)
trichloroethene  (EXP)
trichostatin A  (ISO)
triclosan  (ISO)
triphenyl phosphate  (ISO)
troglitazone  (ISO)
urethane  (EXP,ISO)
usnic acid  (ISO)
valproic acid  (ISO)
vanadium atom  (ISO)
vanadium(0)  (ISO)
vinclozolin  (EXP)
vorinostat  (ISO)
wogonin  (ISO)
zinc atom  (ISO)
zinc oxide  (ISO)
zinc pyrithione  (ISO)
zinc(0)  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Pathway Annotations     Click to see Annotation Detail View
acetylsalicylic acid pharmacodynamics pathway  (ISO)
antipyrine drug pathway  (ISO)
arachidonic acid metabolic pathway  (IEA,ISO)
celecoxib pharmacodynamics pathway  (ISO)
celecoxib pharmacokinetics pathway   (ISO)
cyclooxygenase mediated pathway of arachidonic acid metabolism  (ISO)
diclofenac pharmacodynamics pathway  (ISO)
diflunisal pharmacodynamics pathway  (ISO)
etodolac pharmacodynamics pathway  (ISO)
etoposide pharmacodynamics pathway  (ISO)
etoposide pharmacokinetics pathway  (ISO)
fenoprofen pharmacodynamics pathway  (ISO)
flurbiprofen pharmacodynamics pathway  (ISO)
ibuprofen pharmacodynamics pathway  (ISO)
ibuprofen pharmacokinetics pathway  (ISO)
indometacin pharmacodynamics pathway  (ISO)
indometacin pharmacodynamics pathway  (ISO)
ketoprofen pharmacodynamics pathway  (ISO)
ketorolac pharmacodynamics pathway  (ISO)
leukotriene C4 synthase deficiency pathway  (ISO)
lornoxicam pharmacodynamics pathway  (ISO)
magnesium salicylate pharmacodynamics pathway  (ISO)
mefenamic acid pharmacodynamics pathway  (ISO)
meloxicam pharmacodynamics pathway  (ISO)
nabumetone pharmacodynamics pathway  (ISO)
naproxen pharmacodynamics pathway   (ISO)
paracetamol drug pathway  (ISO)
piroxicam pharmacodynamics pathway   (ISO)
prostanoid biosynthetic pathway  (ISO)
salicylic acid pharmacodynamics pathway  (ISO)
sodium salicylate pharmacodynamics pathway  (ISO)
sulindac pharmacodynamics pathway  (ISO)
tenoxicam pharmacodynamics pathway  (ISO)
tiaprofenic acid pharmacodynamics pathway  (ISO)
tolmetin pharmacodynamics pathway  (ISO)
valdecoxib pharmacodynamics pathway  (ISO)


References - curated
# Reference Title Reference Citation
1. Gene expression of cyclooxygenase-1 and Ca(2+)-independent phospholipase A(2) is altered in rat hippocampus during normal aging. Aid S and Bosetti F, Brain Res Bull. 2007 Jun 15;73(1-3):108-13. Epub 2007 Mar 20.
2. COX-1 and COX-2 expression in stage I and II invasive cervical carcinoma: relationship to disease relapse and long-term survival. Athavale R, etal., Int J Gynecol Cancer. 2006 May-Jun;16(3):1303-8.
3. Cyclooxygenase expression and prostaglandin levels in central nervous system tissues during the course of chronic relapsing experimental autoimmune encephalomyelitis (EAE). Ayoub SS, etal., Inflamm Res. 2011 Oct;60(10):919-28. Epub 2011 Jun 12.
4. [Prognostic significance of cyclooxygenase (COX-1 and COX-2) expression in endometrial carcinoma (clinical and immunohistochemical study)] Boldarian NA, etal., Vopr Onkol. 2008;54(1):40-6.
5. Key enzymes for renal prostaglandin synthesis: site-specific expression in rodent kidney (rat, mouse). Campean V, etal., Am J Physiol Renal Physiol 2003 Jul;285(1):F19-32. Epub 2003 Mar 25.
6. Cyclooxygenase inhibition limits blood-brain barrier disruption following intracerebral injection of tumor necrosis factor-alpha in the rat. Candelario-Jalil E, etal., J Pharmacol Exp Ther. 2007 Nov;323(2):488-98. Epub 2007 Aug 17.
7. Selective cyclooxygenase inhibition improves hepatic encephalopathy in fulminant hepatic failure of rat. Chang CC, etal., Eur J Pharmacol. 2011 Sep;666(1-3):226-32. Epub 2011 May 10.
8. Cyclooxygenase-1 null mice show reduced neuroinflammation in response to beta-amyloid. Choi SH and Bosetti F, Aging (Albany NY). 2009 Feb 11;1(2):234-44.
9. Anti-inflammatory effect of low intensity ultrasound (LIUS) on complete Freund's adjuvant-induced arthritis synovium. Chung JI, etal., Osteoarthritis Cartilage. 2012 Jan 24.
10. Cyclooxygenase-1 is a potential target for prevention and treatment of ovarian epithelial cancer. Daikoku T, etal., Cancer Res. 2005 May 1;65(9):3735-44.
11. Cyclooxygenases-1 and -2 are differentially localized to microglia and endothelium in rat EAE and glioma. Deininger MH and Schluesener HJ, J Neuroimmunol. 1999 Mar 1;95(1-2):202-8.
12. Cyclooxygenase (COX)-1 expressing macrophages/microglial cells and COX-2 expressing astrocytes accumulate during oligodendroglioma progression. Deininger MH, etal., Brain Res. 2000 Dec 1;885(1):111-6.
13. Cyclooxygenase-1 and -2 in brains of patients who died with sporadic Creutzfeldt-Jakob disease. Deininger MH, etal., J Mol Neurosci. 2003 Feb;20(1):25-30.
14. Neuroprotective Effect of Cyclooxygenase Inhibitors in ICV-STZ Induced Sporadic Alzheimer's Disease in Rats. Dhull DK, etal., J Mol Neurosci. 2012 Jan;46(1):223-35. Epub 2011 Jun 24.
15. Cyclooxygenase-2 (Cox-2) in injured human nerve and a rat model of nerve injury. Durrenberger PF, etal., J Peripher Nerv Syst. 2004 Mar;9(1):15-25.
16. Pathophysiological basis of acute inflammatory hyperaemia in the rat knee: roles of cyclo-oxygenase-1 and -2. Egan CG, etal., J Physiol 2002 Mar 1;539(Pt 2):579-87.
17. Cloning two isoforms of rat cyclooxygenase: differential regulation of their expression. Feng L, etal., Arch Biochem Biophys 1993 Dec;307(2):361-8.
18. Elevated spinal cyclooxygenase and prostaglandin release during hyperalgesia in diabetic rats. Freshwater JD, etal., Diabetes 2002 Jul;51(7):2249-55.
19. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
20. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
21. The modern pharmacology of paracetamol: therapeutic actions, mechanism of action, metabolism, toxicity and recent pharmacological findings. Graham GG, etal., Inflammopharmacology. 2013 Jun;21(3):201-32. doi: 10.1007/s10787-013-0172-x. Epub 2013 May 30.
22. Identification of four new quantitative trait loci regulating arthritis severity and one new quantitative trait locus regulating autoantibody production in rats with collagen-induced arthritis. Griffiths MM, etal., Arthritis Rheum 2000 Jun;43(6):1278-89
23. Cyclooxygenase-1 is overexpressed and promotes angiogenic growth factor production in ovarian cancer. Gupta RA, etal., Cancer Res. 2003 Mar 1;63(5):906-11.
24. Role of prostacyclin in the development of compression trauma-induced spinal cord injury in rats. Harada N, etal., J Neurotrauma. 2006 Dec;23(12):1739-49.
25. Minor salivary gland carcinoma: a review of 35 cases. Haymerle G, etal., Eur Arch Otorhinolaryngol. 2016 Sep;273(9):2717-26. doi: 10.1007/s00405-015-3805-4. Epub 2015 Oct 23.
26. Cyclooxygenase-dependent vasoconstricting factor(s) in remodelled rat femoral arteries. Hirao A, etal., Cardiovasc Res. 2008 Jul 1;79(1):161-8. Epub 2008 May 2.
27. Prostanoids as regulators of innate and adaptive immunity. Hirata T and Narumiya S, Adv Immunol. 2012;116:143-74. doi: 10.1016/B978-0-12-394300-2.00005-3.
28. Endothelium-dependent metabolism by endocannabinoid hydrolases and cyclooxygenases limits vasorelaxation to anandamide and 2-arachidonoylglycerol. Ho WS and Randall MD, Br J Pharmacol. 2007 Mar;150(5):641-51. Epub 2007 Jan 22.
29. Expression of cyclooxygenase-1 and cyclooxygenase-2 in human breast cancer. Hwang D, etal., J Natl Cancer Inst. 1998 Mar 18;90(6):455-60.
30. Increased susceptibility to ischemic brain injury in cyclooxygenase-1-deficient mice. Iadecola C, etal., J Cereb Blood Flow Metab. 2001 Dec;21(12):1436-41.
31. The pathophysiological roles of COX-1 and COX-2 in the intestinal smooth muscle contractility under the anaphylactic condition. Kadowaki H, etal., Biomed Res. 2008 Apr;29(2):113-7.
32. Suppressing inflammatory cascade by cyclo-oxygenase inhibitors attenuates quinolinic acid induced Huntington's disease-like alterations in rats. Kalonia H and Kumar A, Life Sci. 2011 Apr 25;88(17-18):784-91. Epub 2011 Feb 26.
33. KEGG: Kyoto Encyclopedia of Genes and Genomes KEGG
34. Effects of genetic deficiency of cyclooxygenase-1 or cyclooxygenase-2 on functional and histological outcomes following traumatic brain injury in mice. Kelso ML, etal., BMC Neurosci. 2009 Aug 31;10:108.
35. Exploratory Translational Modeling Approach in Drug Development to Predict Human Brain Pharmacokinetics and Pharmacologically Relevant Clinical Doses. Kielbasa W and Stratford RE, Drug Metab Dispos. 2012 Jan 27.
36. Altered arachidonic acid cascade enzymes in postmortem brain from bipolar disorder patients. Kim HW, etal., Mol Psychiatry. 2011 Apr;16(4):419-28. Epub 2009 Dec 29.
37. Cyclooxygenase-1-derived prostaglandins in the periaqueductal gray differentially control C- versus A-fiber-evoked spinal nociception. Leith JL, etal., J Neurosci. 2007 Oct 17;27(42):11296-305.
38. 15d-prostaglandin J2 protects brain from ischemia-reperfusion injury. Lin TN, etal., Arterioscler Thromb Vasc Biol. 2006 Mar;26(3):481-7. Epub 2005 Dec 29.
39. Brain neuronal/inducible nitric oxide synthases and cyclooxygenase-1 are involved in the bombesin-induced activation of central adrenomedullary outflow in rats. Lu L, etal., Eur J Pharmacol. 2008 Aug 20;590(1-3):177-84. Epub 2008 Jun 18.
40. Role for both spinal cord COX-1 and COX-2 in maintenance of mechanical hypersensitivity following peripheral nerve injury. Ma W, etal., Brain Res 2002 May 24;937(1-2):94-9.
41. Molecular mechanisms regulating the vascular prostacyclin pathways and their adaptation during pregnancy and in the newborn. Majed BH and Khalil RA, Pharmacol Rev. 2012 Jul;64(3):540-82. doi: 10.1124/pr.111.004770. Epub 2012 Jun 7.
42. Urethane suppresses rat lung inducible cyclooxygenase and nitric oxide synthase mRNA levels. Martinez FE, etal., Inflamm Res. 2000 Dec;49(12):727-31.
43. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
44. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
45. Spinal prostaglandins facilitate exaggerated A- and C-fiber-mediated reflex responses and are critical to the development of allodynia early after L5-L6 spinal nerve ligation. O'Rielly DD and Loomis CW, Anesthesiology. 2007 Apr;106(4):795-805.
46. Down-regulation of cyclooxygenase-2 expression but up-regulation of cyclooxygenase-1 in renal carcinomas of the Eker (TSC2 gene mutant) rat model. Okamoto T, etal., Cancer Sci. 2003 Jan;94(1):22-5.
47. Aggravation by selective COX-1 and COX-2 inhibitors of dextran sulfate sodium (DSS)-induced colon lesions in rats. Okayama M, etal., Dig Dis Sci. 2007 Sep;52(9):2095-103. Epub 2007 Apr 12.
48. Characterization of the Prostaglandin E2 path way in a Rat Model of Esophageal Adenocarcinoma. Piazuelo E, etal., Curr Cancer Drug Targets. 2011 Oct 27.
49. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
50. SMPDB Annotation Import Pipeline Pipeline to import SMPDB annotations from SMPDB into RGD
51. Increased gene expression and production of spinal cyclooxygenase 1 and 2 during experimental osteoarthritis pain. Prochazkova M, etal., Physiol Res. 2008 Jul 18.
52. Dietary n-3 PUFA deprivation alters expression of enzymes of the arachidonic and docosahexaenoic acid cascades in rat frontal cortex. Rao JS, etal., Mol Psychiatry. 2007 Feb;12(2):151-7. Epub 2006 Sep 19.
53. GOA pipeline RGD automated data pipeline
54. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
55. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
56. Comprehensive gene review and curation RGD comprehensive gene curation
57. Upregulation of COX-1 and COX-2 in nasal polyps in cystic fibrosis. Roca-Ferrer J, etal., Thorax. 2006 Jul;61(7):592-6. Epub 2006 Mar 3.
58. Selective COX-2 inhibition markedly slows disease progression and attenuates altered prostanoid production in Han:SPRD-cy rats with inherited kidney disease. Sankaran D, etal., Am J Physiol Renal Physiol. 2007 Sep;293(3):F821-30. Epub 2007 May 30.
59. Selective accumulation of cyclooxygenase-1-expressing microglial cells/macrophages in lesions of human focal cerebral ischemia. Schwab JM, etal., Acta Neuropathol. 2000 Jun;99(6):609-14.
60. Persistent accumulation of cyclooxygenase-1 (COX-1) expressing microglia/macrophages and upregulation by endothelium following spinal cord injury. Schwab JM, etal., J Neuroimmunol. 2000 Nov 1;111(1-2):122-30.
61. Persistent accumulation of cyclooxygenase-1-expressing microglial cells and macrophages and transient upregulation by endothelium in human brain injury. Schwab JM, etal., J Neurosurg. 2002 May;96(5):892-9.
62. Traumatic brain injury induces prolonged accumulation of cyclooxygenase-1 expressing microglia/brain macrophages in rats. Schwab JM, etal., J Neurotrauma. 2001 Sep;18(9):881-90.
63. Involvement of cyclooxygenase-1 and -2 in the sciatic nerve of rats with experimental autoimmune neuritis. Shin T, etal., Immunol Invest. 2003 Aug;32(3):123-30.
64. Inhibitors of GSK-3 prevent corticosterone from inducing COX-1 expression in cardiomyocytes. Sun H and Chen QM, Cardiovasc Toxicol. 2008 Summer;8(2):93-100. Epub 2008 Jun 27.
65. Post-training cyclooxygenase-2 (COX-2) inhibition impairs memory consolidation. Teather LA, etal., Learn Mem 2002 Jan-Feb;9(1):41-7.
66. Expression and activity of cyclooxygenase isoforms in skeletal muscles and myocardium of humans and rodents. Testa M, etal., J Appl Physiol. 2007 Oct;103(4):1412-8. Epub 2007 Aug 2.
67. Roles of vasoconstrictor prostaglandins, COX-1 and -2, and AT1, AT2, and TP receptors in a rat model of early 2K,1C hypertension. Welch WJ, etal., Am J Physiol Heart Circ Physiol. 2007 Nov;293(5):H2644-9. Epub 2007 Aug 31.
68. Nasal mucosal expression of the leukotriene and prostanoid pathways in seasonal and perennial allergic rhinitis. Westergren VS, etal., Clin Exp Allergy. 2009 Jun;39(6):820-8. Epub 2009 Apr 2.
69. A novel animal model to investigate fractionated radiotherapy-induced alimentary mucositis: the role of apoptosis, p53, nuclear factor-kappaB, COX-1, and COX-2. Yeoh AS, etal., Mol Cancer Ther. 2007 Aug;6(8):2319-27.
70. Cyclooxygenase-1 in human Alzheimer and control brain: quantitative analysis of expression by microglia and CA3 hippocampal neurons. Yermakova AV, etal., J Neuropathol Exp Neurol. 1999 Nov;58(11):1135-46.
71. Activated microglia in the human glaucomatous optic nerve head. Yuan L and Neufeld AH, J Neurosci Res. 2001 Jun 1;64(5):523-32.
72. Cyclooxygenase-1 in the spinal cord is altered after peripheral nerve injury. Zhu X and Eisenach JC, Anesthesiology. 2003 Nov;99(5):1175-9.
Additional References at PubMed
PMID:1380156   PMID:7864644   PMID:10987272   PMID:11758166   PMID:11849824   PMID:11861778   PMID:12021206   PMID:12093889   PMID:12160205   PMID:12355421   PMID:12467530   PMID:12477932  
PMID:12811798   PMID:12855310   PMID:12888618   PMID:12971960   PMID:14600435   PMID:14613912   PMID:14684611   PMID:15059644   PMID:15207919   PMID:15351851   PMID:15550559   PMID:15633603  
PMID:15644490   PMID:15650114   PMID:15795519   PMID:15935072   PMID:16189289   PMID:16323955   PMID:16357083   PMID:16569634   PMID:16621493   PMID:16781129   PMID:16788145   PMID:16949875  
PMID:17196338   PMID:18292448   PMID:18335410   PMID:18349208   PMID:18414395   PMID:18570454   PMID:19056763   PMID:19060365   PMID:19155631   PMID:19444941   PMID:19449290   PMID:19515980  
PMID:19625688   PMID:19632905   PMID:19658194   PMID:19668263   PMID:19696359   PMID:19845835   PMID:19912740   PMID:19937640   PMID:20549385   PMID:20735829   PMID:21680698   PMID:22219191  
PMID:22436078   PMID:23002358   PMID:23090753   PMID:23358504   PMID:23362192   PMID:23401543   PMID:24014677   PMID:25216050   PMID:25811420   PMID:26612417   PMID:27178425   PMID:27923787  
PMID:28933223   PMID:32909857   PMID:34348138  


Comparative Map Data
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
GRCr8339,981,419 - 40,002,993 (+)NCBIGRCr8
mRatBN7.2319,584,015 - 19,605,589 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl319,584,015 - 19,605,586 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx322,661,928 - 22,683,470 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0331,246,853 - 31,268,395 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0329,494,672 - 29,516,226 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0315,560,685 - 15,582,339 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl315,560,712 - 15,582,344 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0320,869,915 - 20,891,512 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4315,343,832 - 15,365,412 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1315,240,203 - 15,261,784 (+)NCBI
Celera314,295,836 - 14,317,392 (+)NCBICelera
Cytogenetic Map3p11NCBI
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
GRCh389122,370,533 - 122,395,703 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl9122,370,530 - 122,395,703 (+)EnsemblGRCh38hg38GRCh38
GRCh379125,132,812 - 125,157,982 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 369124,173,050 - 124,197,802 (+)NCBINCBI36Build 36hg18NCBI36
Build 349122,212,782 - 122,237,535NCBI
Celera995,781,549 - 95,806,298 (+)NCBICelera
Cytogenetic Map9q33.2NCBI
HuRef994,747,532 - 94,772,698 (+)NCBIHuRef
CHM1_19125,280,871 - 125,306,038 (+)NCBICHM1_1
T2T-CHM13v2.09134,568,002 - 134,593,163 (+)NCBIT2T-CHM13v2.0
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
GRCm39236,106,758 - 36,142,287 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl236,120,438 - 36,142,284 (+)EnsemblGRCm39 Ensembl
GRCm38236,216,742 - 36,258,593 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl236,230,426 - 36,252,272 (+)EnsemblGRCm38mm10GRCm38
MGSCv37236,085,946 - 36,107,789 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36236,052,536 - 36,074,271 (+)NCBIMGSCv36mm8
Celera235,934,252 - 35,956,092 (+)NCBICelera
Cytogenetic Map2BNCBI
cM Map224.19NCBI
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
ChiLan1.0 EnsemblNW_0049554195,678,694 - 5,699,305 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049554195,678,750 - 5,699,305 (-)NCBIChiLan1.0ChiLan1.0
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
NHGRI_mPanPan1-v21116,953,759 - 16,975,988 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1916,953,703 - 16,978,307 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0993,495,365 - 93,517,557 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.19121,837,095 - 121,859,283 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl9121,837,095 - 121,859,283 (+)Ensemblpanpan1.1panPan2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
CanFam3.1960,195,118 - 60,216,847 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl960,195,124 - 60,216,819 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha959,390,579 - 59,412,227 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0961,110,468 - 61,132,351 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl961,110,470 - 61,132,343 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1959,884,516 - 59,906,289 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0960,200,281 - 60,222,098 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0960,289,919 - 60,311,671 (-)NCBIUU_Cfam_GSD_1.0
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
HiC_Itri_2NW_024404947190,976,385 - 190,990,294 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493648710,745,327 - 10,758,823 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_00493648710,745,465 - 10,758,812 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
Sscrofa11.1 Ensembl1262,456,155 - 262,483,035 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11262,456,106 - 262,482,159 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21294,753,789 - 294,779,835 (+)NCBISscrofa10.2Sscrofa10.2susScr3
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
ChlSab1.11217,195,403 - 17,218,450 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1217,192,628 - 17,218,315 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366603525,831,631 - 25,856,861 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
HetGla_female_1.0 EnsemblNW_00462476012,915,206 - 12,937,824 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462476012,917,244 - 12,937,858 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2


Variants in Ptgs1
82 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:96
Count of miRNA genes:83
Interacting mature miRNAs:87
Prediction methods:Miranda
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (
For more information about miRGate, see PMID:25858286 or access the full paper here.

QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1358357Srcrtb1Stress Responsive Cort Basal QTL 16.360.002blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)3865816227494778Rat
6893355Bw101Body weight QTL 1010.40.38body mass (VT:0001259)body weight (CMO:0000012)31077870430357018Rat
634306Bp140Blood pressure QTL 1403.30.0013arterial blood pressure trait (VT:2000000)body weight (CMO:0000012)31737470335528639Rat
10401810Kidm53Kidney mass QTL 53kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)3822719447233430Rat
1298526Arunc3Aerobic running capacity QTL 32.2exercise endurance trait (VT:0002332)maximum distance run on treadmill (CMO:0001406)3822719433703538Rat
2298542Neuinf11Neuroinflammation QTL 113.9nervous system integrity trait (VT:0010566)spinal cord complement component 1, q subcomponent, B chain mRNA level (CMO:0002126)31500542276927699Rat
1558657Cm43Cardiac mass QTL 436.63e-08heart mass (VT:0007028)heart wet weight (CMO:0000069)31077882330356773Rat
631568Bp92Blood pressure QTL 922.20.005arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)3139874793Rat
6893363Bw105Body weight QTL 1052.60.0036body mass (VT:0001259)body weight (CMO:0000012)31077870430357018Rat
61468Bp15Blood pressure QTL 154.4blood pressure trait (VT:0000183)pulse pressure (CMO:0000292)3133278763Rat
631831Alc8Alcohol consumption QTL 82.7consumption behavior trait (VT:0002069)calculated ethanol drink intake rate (CMO:0001615)3133230976Rat
1558647Cm46Cardiac mass QTL 465.40.0000055heart mass (VT:0007028)heart wet weight (CMO:0000069)31077882330356773Rat
4889966Bss95Bone structure and strength QTL 954.4tibia area (VT:1000281)tibia-fibula cross-sectional area (CMO:0001718)3136847613Rat
12879852Cm93Cardiac mass QTL 930.001heart right ventricle mass (VT:0007033)heart right ventricle weight to body weight ratio (CMO:0000914)31831145447233430Rat
1558654Bw56Body weight QTL 564.50.0000171body mass (VT:0001259)body weight (CMO:0000012)31077870430357018Rat
12879853Am5Aortic mass QTL 50.001aorta mass (VT:0002845)aorta weight to aorta length to body weight ratio (CMO:0002722)31831145447233430Rat
12879854Kidm63Kidney mass QTL 630.001kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)31831145447233430Rat
1558650Cm48Cardiac mass QTL 4840.0001heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)31077882330356773Rat
1358905Hrtrt17Heart rate QTL 175.90.000014heart pumping trait (VT:2000009)heart rate (CMO:0000002)31086191289878372Rat
12879849Bw180Body weight QTL 1800.037body mass (VT:0001259)body weight (CMO:0000012)31831145447233430Rat
70191BpQTLcluster4Blood pressure QTL cluster 43arterial blood pressure trait (VT:2000000)absolute change in systolic blood pressure (CMO:0000607)31077870450302886Rat
12879850Cm91Cardiac mass QTL 910.001heart mass (VT:0007028)heart wet weight to body weight ratio (CMO:0002408)31831145447233430Rat
731172Bp151Blood pressure QTL 1510.04arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)31831145447233430Rat
12879851Cm92Cardiac mass QTL 920.001heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)31831145447233430Rat
631545Bp85Blood pressure QTL 853.1arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)3133278763Rat
1358885Bp251Blood pressure QTL 2513.8arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)314489145121056321Rat
2325840Bp345Blood pressure QTL 3450.001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)31831145428441896Rat
631676Cm8Cardiac mass QTL 87.030.0001aorta mass (VT:0002845)aorta weight (CMO:0000076)31695470861954708Rat
631679Cm10Cardiac mass QTL 107.340.0001heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)3131158234Rat
2290452Scl56Serum cholesterol level QTL 562.26blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)3191609953Rat
70203Gcr2Gastric cancer resistance QTL 22.6stomach morphology trait (VT:0000470)stomach tumor susceptibility score (CMO:0002043)3865816227494778Rat
70202Alc19Alcohol consumption QTL 192.5drinking behavior trait (VT:0001422)ethanol intake volume to total fluid intake volume ratio (CMO:0001591)3127494778Rat
2312664Scl62Serum cholesterol level QTL 620.05blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)3138710544Rat
1358888Bp264Blood pressure QTL 2644.43arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)314489145121056321Rat

Markers in Region
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2319,605,387 - 19,605,573 (+)MAPPERmRatBN7.2
Rnor_6.0315,582,138 - 15,582,323NCBIRnor6.0
Rnor_5.0320,891,311 - 20,891,496UniSTSRnor5.0
RGSC_v3.4315,365,214 - 15,365,399UniSTSRGSC3.4
Celera314,317,191 - 14,317,376UniSTS
RH 3.4 Map3178.3UniSTS
Cytogenetic Map3p11UniSTS
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2319,595,695 - 19,595,854 (+)MAPPERmRatBN7.2
Rnor_6.0315,572,448 - 15,572,606NCBIRnor6.0
Rnor_5.0320,881,621 - 20,881,779UniSTSRnor5.0
RGSC_v3.4315,355,524 - 15,355,682UniSTSRGSC3.4
Celera314,307,504 - 14,307,662UniSTS
RH 3.4 Map3184.81UniSTS
Cytogenetic Map3p11UniSTS
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2319,604,874 - 19,605,007 (+)MAPPERmRatBN7.2
Rnor_6.0315,581,625 - 15,581,757NCBIRnor6.0
Rnor_5.0320,890,798 - 20,890,930UniSTSRnor5.0
RGSC_v3.4315,364,701 - 15,364,833UniSTSRGSC3.4
Celera314,316,678 - 14,316,810UniSTS
RH 3.4 Map11629.1UniSTS
Cytogenetic Map3p11UniSTS


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
Medium 3 4 38 38 11 38 13 16 11
Low 39 19 3 8 3 8 11 74 22 22 8
Below cutoff 3


RefSeq Acc Id: ENSRNOT00000010218   ⟹   ENSRNOP00000010218
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl319,584,015 - 19,605,586 (+)Ensembl
Rnor_6.0 Ensembl315,560,712 - 15,582,344 (+)Ensembl
RefSeq Acc Id: NM_017043   ⟹   NP_058739
RefSeq Status: VALIDATED
Rat AssemblyChrPosition (strand)Source
GRCr8339,981,419 - 40,002,993 (+)NCBI
mRatBN7.2319,584,015 - 19,605,589 (+)NCBI
Rnor_6.0315,560,723 - 15,582,339 (+)NCBI
Rnor_5.0320,869,915 - 20,891,512 (+)NCBI
RGSC_v3.4315,343,832 - 15,365,412 (+)RGD
Celera314,295,836 - 14,317,392 (+)NCBI
RefSeq Acc Id: NP_058739   ⟸   NM_017043
- Peptide Label: precursor
- UniProtKB: Q63921 (UniProtKB/Swiss-Prot),   Q63684 (UniProtKB/Swiss-Prot),   Q62731 (UniProtKB/Swiss-Prot),   Q66HK3 (UniProtKB/TrEMBL),   F7EWD5 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSRNOP00000010218   ⟸   ENSRNOT00000010218
Protein Domains

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q63921-F1-model_v2 AlphaFold Q63921 1-602 view protein structure


eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

RGD ID:13692025
Promoter ID:EPDNEW_R2549
Type:initiation region
Description:prostaglandin-endoperoxide synthase 1
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database,
Experiment Methods:Single-end sequencing.
Rat AssemblyChrPosition (strand)Source
Rnor_6.0315,560,719 - 15,560,779EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:3439 AgrOrtholog
BioCyc Gene G2FUF-50010 BioCyc
BioCyc Pathway PWY66-374 [C20 prostanoid biosynthesis] BioCyc
BioCyc Pathway Image PWY66-374 BioCyc
Ensembl Genes ENSRNOG00000007415 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000010218 ENTREZGENE
  ENSRNOT00000010218.6 UniProtKB/TrEMBL
Gene3D-CATH 1.10.640.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Laminin UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro EGF-like_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Haem_peroxidase_animal UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Haem_peroxidase_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Haem_peroxidase_sf_animal UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:24693 UniProtKB/TrEMBL
  PTHR11903:SF6 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam An_peroxidase UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Ptgs1 PhenoGen
PROSITE EGF_3 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PEROXIDASE_3 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
RatGTEx ENSRNOG00000007415 RatGTEx
Superfamily-SCOP EGF/Laminin UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SSF48113 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PGH1_RAT UniProtKB/Swiss-Prot
UniProt Secondary Q62731 UniProtKB/Swiss-Prot
  Q63684 UniProtKB/Swiss-Prot

Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2003-04-09 Ptgs1  prostaglandin-endoperoxide synthase 1  Ptgs1  prostaglandin-endoperoxide synthase 1 (prostaglandin G/H synthase and cyclooxygenase)  Name updated 629478 APPROVED